Light reinforcement 2

Light reinforcement, proportion of active snout-poke responses for 5-sec light onset to the total active and inactive responses in the last three 18-minute sessions during the light reinforcement phase for males and females [proportion]

Tags: Behavior · Light reinforcement

Project: p50_david_dietz

3 loci · 3 genes with independent associations · 4 total associated genes

Significant Loci

#	Chr	Start pos	End pos	# assoc genes	# joint models	Best TWAS P	Best GWAS P	Cond GWAS P	Joint genes
1	1	68581504	69974370	1	1	9.56e-08	5.71e-02	6.54e-10	Syt5
2	1	140614300	142727457	2	1	3.24e-09	1.24e-09	1.00e+00	Grm5
3	5	58534361	59934060	1	1	7.60e-08	2.09e-04	1.35e-06	Grhpr

Pleiotropic Associations

Trait	Chi² ratio	# genes⁺	# genes⁺⁺	% genes⁺⁺	Corr	Corr P	Genes
Body weight	2.58	1	0	0	0	1.00e+00	Syt5
Glucose	12.08	1	0	0	0	1.00e+00	Syt5
Liver weight, left	10.21	1	0	0	0	1.00e+00	Syt5
Liver weight, right	8.22	2	0	0	0	1.00e+00	Grm5 Syt5
Intraocular pressure	10.2	2	0	0	-0.99	3.24e-09	Grm5 Ctsc
Tibia length	7.53	1	0	0	0	1.00e+00	Syt5
Mean time between licks in bursts	7.52	2	0	0	1	8.08e-10	Grm5 Ctsc
Std. dev. time between licks in bursts	22.72	1	1	33.3	0	1.00e+00	Syt5
Indifference point 0 sec	6.32	1	0	0	0	1.00e+00	Syt5
Indifference point function ln k	8.79	1	0	0	0	1.00e+00	Syt5
Indifference point function log k	8.79	1	0	0	0	1.00e+00	Syt5
Delay discounting total patch changes 0 sec	5.75	1	0	0	0	1.00e+00	Syt5
Delay discounting total patch changes 18 sec	7.21	1	0	0	0	1.00e+00	Grhpr
Delay discounting total patch changes 24 sec	10.35	1	0	0	0	1.00e+00	Syt5
Delay discounting time to switch 0 sec	15.64	3	1	33.3	0.46	2.99e-01	Grm5 Ctsc Syt5
Delay discounting water rate 0 sec	7.12	3	0	0	-0.49	5.05e-01	Grm5 Ctsc Syt5
Delay discounting water rate 12 sec	12.5	3	2	66.7	-0.74	2.16e-02	Grm5 Ctsc Syt5
Delay discounting water rate 18 sec	19.78	3	2	66.7	-0.85	5.35e-04	Grm5 Ctsc Syt5
Delay discounting water rate 24 sec	7.14	3	0	0	-0.71	1.14e-01	Grm5 Ctsc Syt5
Delay discounting water rate 6 sec	7.48	2	0	0	-1	7.17e-06	Grm5 Ctsc
Locomotor activity	5.62	2	0	0	0	1.00e+00	Grm5 Ctsc
Light reinforcement 1	11.27	4	1	33.3	0.99	8.73e-11	Grhpr Grm5 Ctsc Syt5
Reaction time num false alarms	12.46	2	0	0	1	1.04e-11	Grm5 Ctsc
Reaction time num false alarms AUC	9.57	3	0	0	1	2.18e-12	Grm5 Ctsc Syt5
Median of all reaction times	6.98	1	0	0	0	1.00e+00	Syt5
Reaction time false alarm rate	12.2	2	0	0	1	2.63e-11	Grm5 Ctsc
Social response proportion	7.98	1	0	0	0	1.00e+00	Syt5
Social time	18.13	1	0	0	0	1.00e+00	Syt5
Cocaine response after cond. corrected	18.2	1	0	0	0	1.00e+00	Syt5
Cocaine response after cond. not corrected	16.42	1	0	0	0	1.00e+00	Syt5
Saline control response	13.17	1	0	0	0	1.00e+00	Syt5
Condit. Reinf. lever presses	9.91	1	0	0	0	1.00e+00	Syt5
Conditioned reinforcement - actives	22.28	1	0	0	0	1.00e+00	Syt5
Conditioned locomotion	15.14	1	0	0	0	1.00e+00	Syt5
Intermitt. access day 1 inactive lever presses	19.07	1	0	0	0	1.00e+00	Syt5
Intermitt. access day 15 inactive lever presses	38.52	1	1	33.3	0	1.00e+00	Syt5
Intermitt. access escalation Index	17.22	1	0	0	0	1.00e+00	Syt5
Intermittent access standard deviation	9.35	1	0	0	0	1.00e+00	Syt5
Post-drug Anxiety	10.17	1	0	0	0	1.00e+00	Syt5
Baseline Anxiety	26.3	1	1	33.3	0	1.00e+00	Syt5
Incentive Sensitization - Breakpoint	8.61	1	0	0	0	1.00e+00	Syt5
Short access day 1 total inactive lever presses	24.45	1	1	33.3	0	1.00e+00	Syt5
Short access day 1 total infusions	9.88	2	0	0	1	2.46e-07	Grm5 Ctsc
Short access day 10 total locomotion	11.18	1	0	0	0	1.00e+00	Syt5
Short access total locomotion	13.05	1	0	0	0	1.00e+00	Syt5
One hour access (shock baseline)	24.39	1	1	33.3	0	1.00e+00	Syt5
Number of responses in last shaping day	9.84	1	0	0	0	1.00e+00	Syt5
Locomotion velocity, session 1	19.89	3	1	33.3	-0.71	1.04e-02	Grm5 Ctsc Syt5
Locomotion distance, session 1	22.42	1	1	33.3	0	1.00e+00	Syt5
Locomotion velocity, session 2	9.42	3	0	0	-0.54	1.69e-01	Grm5 Ctsc Syt5
Locomotion velocity, session 3	9.08	1	0	0	0	1.00e+00	Grhpr
Locomotion distance, session 3	9.09	3	0	0	-0.84	1.27e-03	Grm5 Ctsc Syt5
Stereotopy head waving bouts, day 3	9.52	2	0	0	1	3.36e-09	Grm5 Ctsc
Locomotion distance, session 7	10.24	1	0	0	0	1.00e+00	Syt5
Locomotion velocity, session 8	8.76	3	0	0	-0.72	2.75e-02	Grm5 Ctsc Syt5
Locomotion distance, session 8	9.21	1	0	0	0	1.00e+00	Syt5
Time in familiar zone, hab. session 1	12.82	1	0	0	0	1.00e+00	Syt5
Time in novel zone, hab. session 1	15.26	1	0	0	0	1.00e+00	Grhpr
Total zone transitions, hab. session 1	8.84	3	1	33.3	-0.58	9.99e-02	Grm5 Ctsc Syt5
Total locomotion distance, hab. session 1	28.09	3	3	100	1	5.07e-14	Grm5 Ctsc Syt5
Locomotion velocity, hab. session 1	28.25	3	2	66.7	1	1.97e-11	Grm5 Ctsc Syt5
Time in familiar zone, hab. session 2	14.1	1	0	0	0	1.00e+00	Syt5
Time in novel zone, hab. session 2	10.37	1	0	0	0	1.00e+00	Grhpr
Total zone transitions, hab. session 2	7.86	1	0	0	0	1.00e+00	Syt5
Total locomotion distance, hab. session 2	34.47	3	2	66.7	0.99	2.77e-10	Grm5 Ctsc Syt5
Locomotion velocity, hab. session 2	32.2	3	2	66.7	0.99	3.93e-11	Grm5 Ctsc Syt5
Time in novel zone, NPP test	12.9	1	0	0	0	1.00e+00	Grhpr
Total locomotion distance, NPP test	41.65	2	2	66.7	1	5.55e-15	Grm5 Ctsc
Locomotion velocity, NPP test	40.08	2	2	66.7	1	3.42e-15	Grm5 Ctsc
Pavlov. Cond. magazine entry latency	10.27	2	0	0	0	1.00e+00	Grhpr Syt5
Pavlov. Cond. intertrial magazine entries	19.53	1	0	0	0	1.00e+00	Syt5
Pavlov. Cond. response bias	13.37	1	0	0	0	1.00e+00	Syt5
Bone: cortical area	6.33	1	0	0	0	1.00e+00	Grhpr
Bone: elastic displacement	7.66	1	0	0	0	1.00e+00	Syt5
Bone: maximum diameter	8.42	1	0	0	0	1.00e+00	Grhpr
Bone: minimum diameter	9	1	0	0	0	1.00e+00	Grhpr
Bone: post-yield work	11.59	1	0	0	0	1.00e+00	Syt5
Bone: tissue strength	13.13	1	0	0	0	1.00e+00	Syt5
Bone: trabecular tissue density	8.22	1	0	0	0	1.00e+00	Syt5
Distance traveled before self-admin	57.56	1	1	33.3	0	1.00e+00	Syt5
Distance traveled after self-admin	56.65	1	1	33.3	0	1.00e+00	Syt5
Delta time in open arm before/after self-admin	18.04	1	0	0	0	1.00e+00	Syt5
Diff in mean of infusions in LGA sessions	20.43	1	0	0	0	1.00e+00	Syt5
Extinction: sum of active levers before priming	36.46	1	1	33.3	0	1.00e+00	Syt5
Active lever presses in extinction session 6	13.69	2	0	0	0	1.00e+00	Grhpr Syt5
Time in closed arm after self-admin	22.26	1	0	0	0	1.00e+00	Syt5
Time in open arm after self-admin	17.09	1	0	0	0	1.00e+00	Syt5
Sum of active levers in priming session hrs 5-6	11.16	2	0	0	0.99	5.01e-05	Ctsc Syt5
Time to tail flick, vehicle, after self-admin	8.02	1	0	0	0	1.00e+00	Grm5
Time to tail flick, test, before self-admin	57.17	1	1	33.3	0	1.00e+00	Syt5
Delta time to tail flick, vehicle, before/after SA	8.61	1	0	0	0	1.00e+00	Syt5
Delta time to tail flick, test, before/after SA	42.42	1	1	33.3	0	1.00e+00	Syt5
Ambulatory time before self-admin	36.65	1	1	33.3	0	1.00e+00	Syt5
Ambulatory time after self-admin	61.31	1	1	33.3	0	1.00e+00	Syt5
Delay disc. indifference point, 0s delay	27.96	1	1	33.3	0	1.00e+00	Syt5
Delay disc. indifference point, 16s delay	24.13	1	0	0	0	1.00e+00	Syt5
Delay disc. indifference point, 24s delay	9.61	1	0	0	0	1.00e+00	Syt5
Bouts of movement, locomotor time 1	56.89	1	1	33.3	0	1.00e+00	Syt5
Total resting periods, locomotor time 1	37.3	1	1	33.3	0	1.00e+00	Syt5
Vertical activity count, locomotor time 1	24.22	1	0	0	0	1.00e+00	Syt5
Bouts of movement, locomotor time 2	12.4	1	0	0	0	1.00e+00	Grhpr
Total resting periods, locomotor time 2	14.4	1	0	0	0	1.00e+00	Grhpr
Rest time, locomotor task time 2	9.12	1	0	0	0	1.00e+00	Syt5
Vertical activity count, locomotor time 2	9.25	1	0	0	0	1.00e+00	Grm5
Weight adjusted by age	8.26	1	0	0	0	1.00e+00	Syt5
Seeking ratio, delayed vs. immediate footshock	29.67	1	1	33.3	0	1.00e+00	Syt5
Locomotion in novel chamber	12.66	1	0	0	0	1.00e+00	Syt5
Progressive ratio	7.56	1	0	0	0	1.00e+00	Syt5
Food seeking constrained by brief footshock	133.39	1	1	33.3	0	1.00e+00	Syt5
Seeking ratio, punishment vs. effort	16.51	1	0	0	0	1.00e+00	Syt5
Latency to leave start box in cocaine runway	10.24	2	0	0	0	1.00e+00	Grm5 Ctsc
Latency to leave start box in cocaine runway, M	9.81	1	0	0	0	1.00e+00	Grm5
Cd content in liver	8.09	3	0	0	1	7.42e-10	Grm5 Ctsc Syt5
Co content in liver	19.37	1	0	0	0	1.00e+00	Syt5
Na content in liver	9.19	1	0	0	-1	3.50e-06	Ctsc
Sr content in liver	66.74	1	1	33.3	0	1.00e+00	Syt5
Zn content in liver	15.77	2	0	0	0	1.00e+00	Grhpr Syt5

Associations by panel

Tissue	RNA modality	# hits	% hits/tests	Avg chisq
Adipose	alternative polyA	0	0	1.32
Adipose	alternative TSS	0	0	1.31
Adipose	gene expression	0	0	1.31
Adipose	isoform ratio	2	0.1	1.3
Adipose	intron excision ratio	2	0.1	1.34
Adipose	mRNA stability	0	0	1.3
BLA	alternative polyA	0	0	1.24
BLA	alternative TSS	0	0	1.22
BLA	gene expression	0	0	1.33
BLA	isoform ratio	0	0	1.36
BLA	intron excision ratio	0	0	1.32
BLA	mRNA stability	2	0.1	1.42
Brain	alternative polyA	0	0	1.26
Brain	alternative TSS	0	0	1.24
Brain	gene expression	1	0	1.34
Brain	isoform ratio	1	0	1.29
Brain	intron excision ratio	0	0	1.4
Brain	mRNA stability	0	0	1.34
Eye	alternative polyA	0	0	1.36
Eye	alternative TSS	0	0	1.19
Eye	gene expression	1	0.1	1.22
Eye	isoform ratio	0	0	1.41
Eye	intron excision ratio	0	0	1.32
Eye	mRNA stability	0	0	1.46
IL	alternative polyA	0	0	1.23
IL	alternative TSS	0	0	1.25
IL	gene expression	1	0	1.33
IL	isoform ratio	0	0	1.27
IL	intron excision ratio	0	0	1.17
IL	mRNA stability	0	0	1.32
LHb	alternative polyA	0	0	1.24
LHb	alternative TSS	0	0	1.41
LHb	gene expression	0	0	1.3
LHb	isoform ratio	0	0	1.29
LHb	intron excision ratio	0	0	1.35
LHb	mRNA stability	0	0	1.48
Liver	alternative polyA	0	0	1.24
Liver	alternative TSS	0	0	1.21
Liver	gene expression	0	0	1.31
Liver	isoform ratio	0	0	1.22
Liver	intron excision ratio	0	0	1.3
Liver	mRNA stability	1	0	1.29
NAcc	alternative polyA	0	0	1.32
NAcc	alternative TSS	0	0	1.32
NAcc	gene expression	1	0	1.32
NAcc	isoform ratio	0	0	1.34
NAcc	intron excision ratio	0	0	1.32
NAcc	mRNA stability	0	0	1.44
OFC	alternative polyA	0	0	1.43
OFC	alternative TSS	0	0	1.27
OFC	gene expression	0	0	1.34
OFC	isoform ratio	0	0	1.33
OFC	intron excision ratio	0	0	1.31
OFC	mRNA stability	0	0	1.33
PL	alternative polyA	0	0	1.29
PL	alternative TSS	0	0	1.28
PL	gene expression	0	0	1.32
PL	isoform ratio	0	0	1.38
PL	intron excision ratio	0	0	1.38
PL	mRNA stability	1	0	1.39