Hub : Traits

Light reinforcement 2

Light reinforcement, proportion of active snout-poke responses for 5-sec light onset to the total active and inactive responses in the last three 18-minute sessions during the light reinforcement phase for males and females [proportion]

Tags: Behavior · Light reinforcement

Project: p50_david_dietz

13 significantly associated models · 4 unique genes

Significant Loci

# chr p0 p1 # assoc genes # joint models best TWAS P best SNP P cond SNP P % var exp joint genes
1 1 68581504 69974370 1 1 9.6e-08 5.7e-02 6.5e-10 -954 Syt5
2 1 140614300 142727457 2 1 3.2e-09 1.2e-09 1.0e+00 100 Grm5
3 5 58534361 59934060 1 1 7.6e-08 2.1e-04 1.3e-06 -70 Grhpr

p0: physical position of the start of the locus. p1: physical position of the end of the locus. # joint models: number of models selected by step-wise conditional analysis.

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Body weight 2.6 1 0 0 0.00 1.0e+00 Syt5
Glucose 12.1 1 0 0 0.00 1.0e+00 Syt5
Liver weight, left 10.2 1 0 0 0.00 1.0e+00 Syt5
Liver weight, right 8.2 2 0 0 0.00 1.0e+00 Grm5 Syt5
Intraocular pressure 10.2 2 0 0 -0.99 3.2e-09 Grm5 Ctsc
Tibia length 7.5 1 0 0 0.00 1.0e+00 Syt5
Mean time between licks in bursts 7.5 2 0 0 1.00 8.1e-10 Grm5 Ctsc
Std. dev. time between licks in bursts 22.7 1 1 33 0.00 1.0e+00 Syt5
Indifference point 0 sec 6.3 1 0 0 0.00 1.0e+00 Syt5
Indifference point function ln k 8.8 1 0 0 0.00 1.0e+00 Syt5
Indifference point function log k 8.8 1 0 0 0.00 1.0e+00 Syt5
Delay discounting total patch changes 0 sec 5.8 1 0 0 0.00 1.0e+00 Syt5
Delay discounting total patch changes 18 sec 7.2 1 0 0 0.00 1.0e+00 Grhpr
Delay discounting total patch changes 24 sec 10.3 1 0 0 0.00 1.0e+00 Syt5
Delay discounting time to switch 0 sec 15.6 3 1 33 0.46 3.0e-01 Grm5 Ctsc Syt5
Delay discounting water rate 0 sec 7.1 3 0 0 -0.49 5.1e-01 Grm5 Ctsc Syt5
Delay discounting water rate 12 sec 12.5 3 2 67 -0.74 2.2e-02 Grm5 Ctsc Syt5
Delay discounting water rate 18 sec 19.8 3 2 67 -0.85 5.3e-04 Grm5 Ctsc Syt5
Delay discounting water rate 24 sec 7.1 3 0 0 -0.71 1.1e-01 Grm5 Ctsc Syt5
Delay discounting water rate 6 sec 7.5 2 0 0 -1.00 7.2e-06 Grm5 Ctsc
Locomotor activity 5.6 2 0 0 0.00 1.0e+00 Grm5 Ctsc
Light reinforcement 1 11.3 4 1 33 0.99 8.7e-11 Grhpr Grm5 Ctsc Syt5
Reaction time num false alarms 12.5 2 0 0 1.00 1.0e-11 Grm5 Ctsc
Reaction time num false alarms AUC 9.6 3 0 0 1.00 2.2e-12 Grm5 Ctsc Syt5
Median of all reaction times 7.0 1 0 0 0.00 1.0e+00 Syt5
Reaction time false alarm rate 12.2 2 0 0 1.00 2.6e-11 Grm5 Ctsc
Social response proportion 8.0 1 0 0 0.00 1.0e+00 Syt5
Social time 18.1 1 0 0 0.00 1.0e+00 Syt5
Cocaine response after cond. corrected 18.2 1 0 0 0.00 1.0e+00 Syt5
Cocaine response after cond. not corrected 16.4 1 0 0 0.00 1.0e+00 Syt5
Saline control response 13.2 1 0 0 0.00 1.0e+00 Syt5
Condit. Reinf. lever presses 9.9 1 0 0 0.00 1.0e+00 Syt5
Conditioned reinforcement - actives 22.3 1 0 0 0.00 1.0e+00 Syt5
Conditioned locomotion 15.1 1 0 0 0.00 1.0e+00 Syt5
Intermitt. access day 1 inactive lever presses 19.1 1 0 0 0.00 1.0e+00 Syt5
Intermitt. access day 15 inactive lever presses 38.5 1 1 33 0.00 1.0e+00 Syt5
Intermitt. access escalation Index 17.2 1 0 0 0.00 1.0e+00 Syt5
Intermittent access standard deviation 9.3 1 0 0 0.00 1.0e+00 Syt5
Post-drug Anxiety 10.2 1 0 0 0.00 1.0e+00 Syt5
Baseline Anxiety 26.3 1 1 33 0.00 1.0e+00 Syt5
Incentive Sensitization - Breakpoint 8.6 1 0 0 0.00 1.0e+00 Syt5
Short access day 1 total inactive lever presses 24.4 1 1 33 0.00 1.0e+00 Syt5
Short access day 1 total infusions 9.9 2 0 0 1.00 2.5e-07 Grm5 Ctsc
Short access day 10 total locomotion 11.2 1 0 0 0.00 1.0e+00 Syt5
Short access total locomotion 13.1 1 0 0 0.00 1.0e+00 Syt5
One hour access (shock baseline) 24.4 1 1 33 0.00 1.0e+00 Syt5
Number of responses in last shaping day 9.8 1 0 0 0.00 1.0e+00 Syt5
Locomotion velocity, session 1 19.9 3 1 33 -0.71 1.0e-02 Grm5 Ctsc Syt5
Locomotion distance, session 1 22.4 1 1 33 0.00 1.0e+00 Syt5
Locomotion velocity, session 2 9.4 3 0 0 -0.54 1.7e-01 Grm5 Ctsc Syt5
Locomotion velocity, session 3 9.1 1 0 0 0.00 1.0e+00 Grhpr
Locomotion distance, session 3 9.1 3 0 0 -0.84 1.3e-03 Grm5 Ctsc Syt5
Stereotopy head waving bouts, day 3 9.5 2 0 0 1.00 3.4e-09 Grm5 Ctsc
Locomotion distance, session 7 10.2 1 0 0 0.00 1.0e+00 Syt5
Locomotion velocity, session 8 8.8 3 0 0 -0.72 2.7e-02 Grm5 Ctsc Syt5
Locomotion distance, session 8 9.2 1 0 0 0.00 1.0e+00 Syt5
Time in familiar zone, hab. session 1 12.8 1 0 0 0.00 1.0e+00 Syt5
Time in novel zone, hab. session 1 15.3 1 0 0 0.00 1.0e+00 Grhpr
Total zone transitions, hab. session 1 8.8 3 1 33 -0.58 1.0e-01 Grm5 Ctsc Syt5
Total locomotion distance, hab. session 1 28.1 3 3 100 1.00 5.1e-14 Grm5 Ctsc Syt5
Locomotion velocity, hab. session 1 28.2 3 2 67 1.00 2.0e-11 Grm5 Ctsc Syt5
Time in familiar zone, hab. session 2 14.1 1 0 0 0.00 1.0e+00 Syt5
Time in novel zone, hab. session 2 10.4 1 0 0 0.00 1.0e+00 Grhpr
Total zone transitions, hab. session 2 7.9 1 0 0 0.00 1.0e+00 Syt5
Total locomotion distance, hab. session 2 34.5 3 2 67 0.99 2.8e-10 Grm5 Ctsc Syt5
Locomotion velocity, hab. session 2 32.2 3 2 67 0.99 3.9e-11 Grm5 Ctsc Syt5
Time in novel zone, NPP test 12.9 1 0 0 0.00 1.0e+00 Grhpr
Total locomotion distance, NPP test 41.6 2 2 67 1.00 5.6e-15 Grm5 Ctsc
Locomotion velocity, NPP test 40.1 2 2 67 1.00 3.4e-15 Grm5 Ctsc
Pavlov. Cond. magazine entry latency 10.3 2 0 0 0.00 1.0e+00 Grhpr Syt5
Pavlov. Cond. intertrial magazine entries 19.5 1 0 0 0.00 1.0e+00 Syt5
Pavlov. Cond. response bias 13.4 1 0 0 0.00 1.0e+00 Syt5
Bone: cortical area 6.3 1 0 0 0.00 1.0e+00 Grhpr
Bone: elastic displacement 7.7 1 0 0 0.00 1.0e+00 Syt5
Bone: maximum diameter 8.4 1 0 0 0.00 1.0e+00 Grhpr
Bone: minimum diameter 9.0 1 0 0 0.00 1.0e+00 Grhpr
Bone: post-yield work 11.6 1 0 0 0.00 1.0e+00 Syt5
Bone: tissue strength 13.1 1 0 0 0.00 1.0e+00 Syt5
Bone: trabecular tissue density 8.2 1 0 0 0.00 1.0e+00 Syt5
Distance traveled before self-admin 57.6 1 1 33 0.00 1.0e+00 Syt5
Distance traveled after self-admin 56.6 1 1 33 0.00 1.0e+00 Syt5
Delta time in open arm before/after self-admin 18.0 1 0 0 0.00 1.0e+00 Syt5
Diff in mean of infusions in LGA sessions 20.4 1 0 0 0.00 1.0e+00 Syt5
Extinction: sum of active levers before priming 36.5 1 1 33 0.00 1.0e+00 Syt5
Active lever presses in extinction session 6 13.7 2 0 0 0.00 1.0e+00 Grhpr Syt5
Time in closed arm after self-admin 22.3 1 0 0 0.00 1.0e+00 Syt5
Time in open arm after self-admin 17.1 1 0 0 0.00 1.0e+00 Syt5
Sum of active levers in priming session hrs 5-6 11.2 2 0 0 0.99 5.0e-05 Ctsc Syt5
Time to tail flick, vehicle, after self-admin 8.0 1 0 0 0.00 1.0e+00 Grm5
Time to tail flick, test, before self-admin 57.2 1 1 33 0.00 1.0e+00 Syt5
Delta time to tail flick, vehicle, before/after SA 8.6 1 0 0 0.00 1.0e+00 Syt5
Delta time to tail flick, test, before/after SA 42.4 1 1 33 0.00 1.0e+00 Syt5
Ambulatory time before self-admin 36.6 1 1 33 0.00 1.0e+00 Syt5
Ambulatory time after self-admin 61.3 1 1 33 0.00 1.0e+00 Syt5
Delay disc. indifference point, 0s delay 28.0 1 1 33 0.00 1.0e+00 Syt5
Delay disc. indifference point, 16s delay 24.1 1 0 0 0.00 1.0e+00 Syt5
Delay disc. indifference point, 24s delay 9.6 1 0 0 0.00 1.0e+00 Syt5
Bouts of movement, locomotor time 1 56.9 1 1 33 0.00 1.0e+00 Syt5
Total resting periods, locomotor time 1 37.3 1 1 33 0.00 1.0e+00 Syt5
Vertical activity count, locomotor time 1 24.2 1 0 0 0.00 1.0e+00 Syt5
Bouts of movement, locomotor time 2 12.4 1 0 0 0.00 1.0e+00 Grhpr
Total resting periods, locomotor time 2 14.4 1 0 0 0.00 1.0e+00 Grhpr
Rest time, locomotor task time 2 9.1 1 0 0 0.00 1.0e+00 Syt5
Vertical activity count, locomotor time 2 9.2 1 0 0 0.00 1.0e+00 Grm5
Weight adjusted by age 8.3 1 0 0 0.00 1.0e+00 Syt5
Seeking ratio, delayed vs. immediate footshock 29.7 1 1 33 0.00 1.0e+00 Syt5
Locomotion in novel chamber 12.7 1 0 0 0.00 1.0e+00 Syt5
Progressive ratio 7.6 1 0 0 0.00 1.0e+00 Syt5
Food seeking constrained by brief footshock 133.4 1 1 33 0.00 1.0e+00 Syt5
Seeking ratio, punishment vs. effort 16.5 1 0 0 0.00 1.0e+00 Syt5
Latency to leave start box in cocaine runway 10.2 2 0 0 0.00 1.0e+00 Grm5 Ctsc
Latency to leave start box in cocaine runway, M 9.8 1 0 0 0.00 1.0e+00 Grm5
Cd content in liver 8.1 3 0 0 1.00 7.4e-10 Grm5 Ctsc Syt5
Co content in liver 19.4 1 0 0 0.00 1.0e+00 Syt5
Na content in liver 9.2 1 0 0 -1.00 3.5e-06 Ctsc
Sr content in liver 66.7 1 1 33 0.00 1.0e+00 Syt5
Zn content in liver 15.8 2 0 0 0.00 1.0e+00 Grhpr Syt5

chisq ratio: Average Chi2 statistic for the selected genes in the secondary trait, divided by the average statistic for all genes in the secondary trait. # genes+: Shared significant genes at Bonferroni correction. # genes++: Shared significant genes at transcriptome-wide significance. % genes++: Number of [++] genes as a percentage of primary trait’s total joint genes. corr: Correlation of effect sizes across the [+] genes.

Associations by panel

tissue modality # hits % hits/tests avg chisq
Adipose alternative polyA 0 0.000 1.3
Adipose alternative TSS 0 0.000 1.3
Adipose gene expression 0 0.000 1.3
Adipose isoform ratio 2 0.071 1.3
Adipose intron excision ratio 2 0.069 1.3
Adipose mRNA stability 0 0.000 1.3
BLA alternative polyA 0 0.000 1.2
BLA alternative TSS 0 0.000 1.2
BLA gene expression 0 0.000 1.3
BLA isoform ratio 0 0.000 1.4
BLA intron excision ratio 0 0.000 1.3
BLA mRNA stability 2 0.099 1.4
Brain alternative polyA 0 0.000 1.3
Brain alternative TSS 0 0.000 1.2
Brain gene expression 1 0.011 1.3
Brain isoform ratio 1 0.032 1.3
Brain intron excision ratio 0 0.000 1.4
Brain mRNA stability 0 0.000 1.3
Eye alternative polyA 0 0.000 1.4
Eye alternative TSS 0 0.000 1.2
Eye gene expression 1 0.089 1.2
Eye isoform ratio 0 0.000 1.4
Eye intron excision ratio 0 0.000 1.3
Eye mRNA stability 0 0.000 1.5
IL alternative polyA 0 0.000 1.2
IL alternative TSS 0 0.000 1.2
IL gene expression 1 0.027 1.3
IL isoform ratio 0 0.000 1.3
IL intron excision ratio 0 0.000 1.2
IL mRNA stability 0 0.000 1.3
LHb alternative polyA 0 0.000 1.2
LHb alternative TSS 0 0.000 1.4
LHb gene expression 0 0.000 1.3
LHb isoform ratio 0 0.000 1.3
LHb intron excision ratio 0 0.000 1.4
LHb mRNA stability 0 0.000 1.5
Liver alternative polyA 0 0.000 1.2
Liver alternative TSS 0 0.000 1.2
Liver gene expression 0 0.000 1.3
Liver isoform ratio 0 0.000 1.2
Liver intron excision ratio 0 0.000 1.3
Liver mRNA stability 1 0.041 1.3
NAcc alternative polyA 0 0.000 1.3
NAcc alternative TSS 0 0.000 1.3
NAcc gene expression 1 0.016 1.3
NAcc isoform ratio 0 0.000 1.3
NAcc intron excision ratio 0 0.000 1.3
NAcc mRNA stability 0 0.000 1.4
OFC alternative polyA 0 0.000 1.4
OFC alternative TSS 0 0.000 1.3
OFC gene expression 0 0.000 1.3
OFC isoform ratio 0 0.000 1.3
OFC intron excision ratio 0 0.000 1.3
OFC mRNA stability 0 0.000 1.3
PL alternative polyA 0 0.000 1.3
PL alternative TSS 0 0.000 1.3
PL gene expression 0 0.000 1.3
PL isoform ratio 0 0.000 1.4
PL intron excision ratio 0 0.000 1.4
PL mRNA stability 1 0.034 1.4

avg chisq: Average Chi2 (squared Z-score) across all models in this panel for this trait.