Light reinforcement 2

Light reinforcement, proportion of active snout-poke responses for 5-sec light onset to the total active and inactive responses in the last three 18-minute sessions during the light reinforcement phase for males and females [proportion]

Tags: Behavior · Light reinforcement

Project: p50_david_dietz

2 loci · 2 genes with independent associations · 11 total associated genes

Significant Loci

#	Chr	Start pos	End pos	# assoc genes	# joint models	Best TWAS P	Best GWAS P	Cond GWAS P	Joint genes
1	chr1	140610199	142727457	10	1	4.54e-09	1.24e-09	1.00e+00	Ctsc
2	chr16	72043796	73442457	1	1	9.08e-08	7.44e-07	5.59e-01	LOC120097408

Pleiotropic Associations

Trait	Chi² ratio	# genes⁺	# genes⁺⁺	% genes⁺⁺	Corr	Corr P	Genes
Liver weight, right	6.76	1	0	0	0	1.00e+00	Grm5
Retroperitoneal fat weight	2.89	1	0	0	0	1.00e+00	Grm5
Intraocular pressure	11.4	3	0	0	-0.99	3.33e-18	Ctsc Grm5 LOC102554680
Mean time between licks in bursts	7.47	3	0	0	1	7.46e-19	Ctsc Grm5 LOC102554680
Patch foraging time to switch 0 sec	8.39	3	0	0	0.99	1.05e-12	Ctsc Grm5 LOC102554680
Patch foraging water rate 0 sec	7.05	1	0	0	0	1.00e+00	Grm5
Patch foraging water rate 12 sec	11.55	3	1	50	-0.99	4.73e-14	Ctsc Grm5 LOC102554680
Patch foraging water rate 18 sec	21.42	3	3	150	-0.99	2.26e-16	Ctsc Grm5 LOC102554680
Patch foraging water rate 24 sec	7.03	2	0	0	-1	8.54e-08	Ctsc Grm5
Patch foraging water rate 6 sec	7.56	2	0	0	-1	5.76e-10	Ctsc Grm5
Locomotor activity	5.95	2	0	0	0	1.00e+00	Ctsc Grm5
Light reinforcement 1	11.65	3	0	0	1	7.82e-26	Ctsc Grm5 LOC102554680
Reaction time num false alarms	13.26	3	0	0	1	2.68e-20	Ctsc Grm5 LOC102554680
Reaction time num false alarms AUC	10.31	3	0	0	1	7.45e-21	Ctsc Grm5 LOC102554680
Reaction time false alarm rate	13.21	3	0	0	1	3.34e-20	Ctsc Grm5 LOC102554680
Short access day 1 total infusions	10.05	3	0	0	1	9.99e-07	Ctsc Grm5 LOC102554680
Locomotion velocity, session 1	17.47	3	0	0	-1	1.92e-22	Ctsc Grm5 LOC102554680
Locomotion velocity, session 2	8.44	3	0	0	-1	3.90e-09	Ctsc Grm5 LOC102554680
Locomotion distance, session 3	9.62	3	0	0	-1	2.39e-17	Ctsc Grm5 LOC102554680
Stereotopy head waving bouts, day 3	9.28	3	0	0	1	4.31e-21	Ctsc Grm5 LOC102554680
Locomotion velocity, session 8	8.21	3	0	0	-1	1.90e-15	Ctsc Grm5 LOC102554680
Total zone transitions, hab. session 1	7.53	3	0	0	-1	2.45e-10	Ctsc Grm5 LOC102554680
Total locomotion distance, hab. session 1	30.03	3	3	150	1	2.15e-26	Ctsc Grm5 LOC102554680
Locomotion velocity, hab. session 1	31.04	3	3	150	1	2.25e-26	Ctsc Grm5 LOC102554680
Total locomotion distance, hab. session 2	36.94	3	3	150	1	2.79e-25	Ctsc Grm5 LOC102554680
Locomotion velocity, hab. session 2	34.34	3	3	150	1	3.73e-25	Ctsc Grm5 LOC102554680
Total locomotion distance, NPP test	42.5	3	3	150	1	5.60e-27	Ctsc Grm5 LOC102554680
Locomotion velocity, NPP test	40.95	3	3	150	1	1.43e-27	Ctsc Grm5 LOC102554680
Sum of active levers in priming session hrs 5-6	10.06	2	0	0	1	7.28e-06	Ctsc Grm5
Vertical activity count, locomotor time 2	9.16	1	0	0	0	1.00e+00	Grm5
Latency to leave start box in cocaine runway	11.45	2	0	0	0.99	8.52e-03	Ctsc Grm5
Latency to leave start box in cocaine runway, M	10.15	1	0	0	0	1.00e+00	Grm5
Cd content in liver	8.55	1	0	0	0	1.00e+00	Ctsc
Na content in liver	9.09	1	0	0	0	1.00e+00	Ctsc

Associations by panel

Tissue	RNA modality	# hits	% hits/tests	Avg chisq
Adipose	alternative polyA	0	0	1.27
Adipose	alternative TSS	0	0	1.33
Adipose	gene expression	0	0	1.32
Adipose	isoform ratio	0	0	1.29
Adipose	intron excision ratio	2	0.1	1.29
Adipose	mRNA stability	0	0	1.28
BLA	alternative polyA	0	0	1.49
BLA	alternative TSS	0	0	1.27
BLA	gene expression	2	0	1.33
BLA	isoform ratio	2	0.1	1.37
BLA	intron excision ratio	0	0	1.35
BLA	mRNA stability	0	0	1.31
Brain	alternative polyA	2	0.1	1.4
Brain	alternative TSS	0	0	1.26
Brain	gene expression	1	0	1.34
Brain	isoform ratio	3	0.1	1.36
Brain	intron excision ratio	0	0	1.41
Brain	mRNA stability	1	0	1.34
Eye	alternative polyA	0	0	1.19
Eye	alternative TSS	0	0	1.44
Eye	gene expression	1	0.1	1.3
Eye	isoform ratio	0	0	1.36
Eye	intron excision ratio	0	0	1.34
Eye	mRNA stability	0	0	1.46
IL	alternative polyA	0	0	1.36
IL	alternative TSS	0	0	1.34
IL	gene expression	1	0	1.36
IL	isoform ratio	0	0	1.41
IL	intron excision ratio	0	0	1.29
IL	mRNA stability	0	0	1.31
LHb	alternative polyA	0	0	1.31
LHb	alternative TSS	0	0	1.28
LHb	gene expression	0	0	1.3
LHb	isoform ratio	0	0	1.27
LHb	intron excision ratio	0	0	1.38
LHb	mRNA stability	0	0	1.36
Liver	alternative polyA	0	0	1.36
Liver	alternative TSS	0	0	1.3
Liver	gene expression	1	0	1.3
Liver	isoform ratio	0	0	1.29
Liver	intron excision ratio	0	0	1.31
Liver	mRNA stability	0	0	1.29
NAcc	alternative polyA	0	0	1.34
NAcc	alternative TSS	0	0	1.33
NAcc	gene expression	2	0	1.33
NAcc	isoform ratio	1	0	1.42
NAcc	intron excision ratio	0	0	1.43
NAcc	mRNA stability	0	0	1.39
OFC	alternative polyA	0	0	1.36
OFC	alternative TSS	0	0	1.34
OFC	gene expression	0	0	1.31
OFC	isoform ratio	0	0	1.44
OFC	intron excision ratio	0	0	1.33
OFC	mRNA stability	0	0	1.32
PL	alternative polyA	0	0	1.39
PL	alternative TSS	0	0	1.36
PL	gene expression	1	0	1.33
PL	isoform ratio	0	0	1.38
PL	intron excision ratio	0	0	1.41
PL	mRNA stability	0	0	1.36
pVTA	alternative polyA	0	0	1.28
pVTA	alternative TSS	0	0	1.33
pVTA	gene expression	0	0	1.33
pVTA	isoform ratio	0	0	1.3
pVTA	intron excision ratio	0	0	1.37
pVTA	mRNA stability	0	0	1.35
RMTg	alternative polyA	0	0	1.2
RMTg	alternative TSS	0	0	1.24
RMTg	gene expression	0	0	1.41
RMTg	isoform ratio	0	0	1.42
RMTg	intron excision ratio	0	0	1.35
RMTg	mRNA stability	0	0	1.3