Hub : Genes

Thap12

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 IL gene expression Thap12 0.5 0.21 2.0e-04 0.03 0.06 0.05 0.05 7.7e-02 1.2e-02 2.3e-02 2.6e-02
2 IC gene expression Thap12 0.25 0.12 1.2e-08 0.13 0.2 0.2 0.08 5.0e-06 7.8e-09 9.4e-09 2.6e-04
3 pVTA isoform ratio NM_001191630.2 0.2 0.09 2.6e-15 0.2 0.19 0.19 0.2 3.1e-16 5.6e-15 2.3e-15 1.2e-15
4 pVTA isoform ratio XM_039113219.1 0.2 0.09 1.3e-15 0.2 0.19 0.2 0.2 2.2e-16 2.2e-15 1.5e-15 6.9e-16
5 PL isoform ratio XM_039113219.1 0.1 0.06 9.2e-09 0.07 0.08 0.07 0.08 1.7e-08 8.8e-09 2.9e-08 1.1e-08
6 Adipose mRNA stability Thap12 0.07 0.04 7.3e-06 0.04 0.04 0.04 0.04 7.7e-05 1.3e-05 3.3e-05 2.8e-05
7 Brain mRNA stability Thap12 0.07 0.05 1.0e-05 0.05 0.05 0.04 0.05 1.3e-05 2.5e-05 2.4e-04 3.2e-05
8 PL isoform ratio NM_001191630.2 0.1 0.06 1.9e-08 0.07 0.07 0.07 0.07 3.0e-08 2.2e-08 8.3e-08 2.4e-08
9 Brain gene expression Thap12 0.27 0.11 0.0e+00 0.19 0.2 0.2 0.2 9.1e-18 1.5e-18 2.4e-18 2.7e-18
10 OFC gene expression Thap12 0.26 0.15 8.7e-04 0.1 0.1 0.1 0.1 2.5e-03 2.3e-03 2.8e-03 2.8e-03
11 NAcc mRNA stability Thap12 0.02 0.02 3.1e-03 0.02 0.01 0.01 0.01 7.9e-04 3.9e-03 3.5e-03 5.7e-03
12 NAcc isoform ratio XM_039113219.1 0.07 0.04 4.3e-08 0.05 0.05 0.05 0.05 8.1e-08 1.4e-08 2.5e-08 6.7e-08
13 BLA gene expression Thap12 0.18 0.12 4.1e-05 0.05 0.08 0.07 0.05 1.2e-03 3.1e-05 1.8e-04 1.0e-03
14 Adipose gene expression Thap12 0.09 0.07 1.8e-05 0.04 0.04 0.04 0.04 9.0e-06 2.3e-05 1.5e-05 1.3e-05
15 NAcc isoform ratio NM_001191630.2 0.06 0.04 3.6e-07 0.04 0.04 0.04 0.04 3.9e-07 1.8e-07 1.7e-07 3.8e-07
16 pVTA gene expression Thap12 0.07 0.05 7.7e-05 0.05 0.06 0.05 0.05 1.3e-04 3.0e-05 7.7e-05 4.1e-05
17 BLA isoform ratio XM_039113219.1 0.12 0.08 3.6e-05 0.05 0.08 0.08 0.07 8.3e-04 7.1e-05 6.1e-05 1.1e-04
18 BLA isoform ratio NM_001191630.2 0.13 0.08 3.0e-05 0.06 0.08 0.08 0.08 6.8e-04 4.6e-05 5.2e-05 7.1e-05
19 NAcc gene expression Thap12 0.09 0.05 1.3e-13 0.09 0.1 0.1 0.1 4.2e-14 1.6e-14 1.8e-14 1.6e-14
20 PL gene expression Thap12 0.11 0.06 1.0e-10 0.09 0.1 0.1 0.09 7.2e-10 8.8e-11 2.4e-11 5.2e-10

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20
Bone: apparent density0.10.10.6-0.2-0.10.2-0.20.20.30.0-0.2-0.0-0.3-0.1-0.0-0.10.8-0.4-0.5-0.3-0.3-0.30.3
Area under the delay curve0.00.10.30.30.40.0-0.00.1-0.30.1-0.10.40.40.20.20.3-0.20.20.40.10.00.3-0.5
BMI with tail0.51.68.1-1.0-0.90.2-0.20.21.00.6-0.3-1.7-1.50.20.6-1.6-0.51.0-1.6-1.5-1.3-2.22.9
BMI without tail0.52.79.2-0.6-0.31.1-1.11.10.81.5-1.3-1.5-1.41.11.5-1.5-1.31.8-1.7-2.7-2.4-2.53.0
Body weight0.62.59.0-0.7-0.40.9-0.90.90.91.3-1.1-1.5-1.40.91.4-1.6-1.11.9-1.7-2.4-2.2-2.43.0
Weight adjusted by age0.10.41.30.00.10.5-0.50.5-0.00.7-0.6-0.3-0.20.70.7-0.2-0.70.8-0.2-1.0-0.9-0.41.1
Bone surface1.52.95.01.61.82.2-2.22.2-1.32.0-2.21.51.21.72.01.3-1.21.60.8-2.2-2.10.80.0
Bone volume0.61.33.00.80.91.6-1.61.5-0.61.3-1.50.60.41.21.40.5-0.71.10.1-1.7-1.7-0.00.8
Breakpoint value in progressive ratio session0.71.22.2-0.9-1.1-1.31.3-1.40.7-1.21.4-0.7-0.6-1.4-1.4-0.51.1-1.3-0.31.41.5-0.3-0.5
Number of licking bursts1.54.56.5-2.5-2.4-2.22.2-2.12.5-2.22.0-2.4-2.5-1.9-1.8-2.52.2-1.7-2.41.51.4-2.01.4
Context. condit. distance diff. score2.12.64.51.81.61.7-1.71.6-2.12.0-1.61.81.91.51.22.1-1.10.91.9-1.4-1.11.4-0.4
Locomotion velocity, session 10.70.82.6-0.4-0.5-1.21.2-1.20.3-1.31.2-0.2-0.0-0.6-1.1-0.20.3-0.80.21.61.50.3-0.7
Locomotion distance, session 10.40.51.80.80.60.0-0.0-0.0-1.00.20.10.81.10.20.00.9-0.80.41.30.40.51.2-1.3
Locomotion velocity, session 20.10.10.40.10.1-0.20.2-0.10.1-0.30.1-0.10.10.20.1-0.2-0.70.40.10.30.20.0-0.5
Locomotion distance, session 20.10.20.70.40.30.1-0.10.1-0.50.2-0.10.30.50.40.20.3-0.80.50.6-0.00.00.5-0.7
Locomotion velocity, session 30.10.10.70.40.10.2-0.2-0.0-0.70.40.00.30.60.3-0.20.7-0.40.00.9-0.10.20.3-0.0
Locomotion distance, session 30.40.51.90.80.50.3-0.30.1-1.10.4-0.00.81.10.2-0.11.1-0.60.11.40.20.41.0-0.8
Stereotopy head waving bouts, day 30.30.41.0-0.8-0.6-0.60.6-0.40.9-0.50.4-0.7-0.9-0.6-0.2-0.90.3-0.3-1.00.30.1-0.90.4
Stereotopy head waving duration, day 30.30.30.50.60.70.5-0.50.6-0.60.5-0.60.70.60.70.50.7-0.60.40.6-0.4-0.40.5-0.5
Locomotion velocity, session 70.40.40.8-0.6-0.8-0.60.6-0.80.4-0.40.8-0.6-0.5-0.5-0.9-0.30.8-0.7-0.30.50.7-0.60.6
Locomotion distance, session 70.10.10.3-0.4-0.5-0.20.2-0.30.3-0.10.3-0.6-0.4-0.1-0.3-0.40.10.0-0.3-0.00.1-0.50.6
Stereotopy head waving bouts, day 71.51.73.81.61.51.0-1.01.1-1.61.1-1.01.81.70.80.91.8-1.00.61.7-0.4-0.41.6-1.9
Stereotopy head waving duration, day 72.12.63.71.91.91.6-1.61.6-1.81.6-1.61.91.81.51.51.9-1.51.21.7-1.1-1.11.6-1.4
Locomotion velocity, session 81.82.13.61.71.81.5-1.51.7-1.61.5-1.61.91.61.51.41.8-1.01.01.4-1.1-1.11.4-0.5
Locomotion distance, session 81.42.03.41.71.51.3-1.31.3-1.91.5-1.21.61.81.31.11.8-1.51.11.8-0.9-0.81.4-1.0
Degree of sensitization distance0.50.61.5-0.5-0.20.3-0.30.40.90.1-0.4-0.8-1.00.30.6-1.10.00.6-1.2-0.9-1.0-1.11.2
Degree of sensitization stereotypy3.43.86.62.42.31.6-1.61.7-2.41.7-1.62.62.51.41.42.5-1.51.22.4-0.7-0.82.5-2.5
Conditioned locomotion0.10.10.4-0.1-0.2-0.30.3-0.5-0.0-0.40.5-0.00.1-0.5-0.60.10.3-0.60.20.50.60.3-0.4
Cocaine response after cond. corrected0.91.32.3-1.3-1.2-1.21.2-1.31.4-1.41.2-1.3-1.3-0.9-0.9-1.50.9-0.6-1.21.10.9-1.10.7
Cocaine response after cond. not corrected0.30.41.0-0.5-0.5-0.80.8-0.80.6-0.90.8-0.5-0.4-0.4-0.6-0.60.5-0.3-0.41.00.8-0.2-0.0
Cocaine response before conditioning1.11.32.81.41.40.7-0.70.9-1.50.9-0.81.71.60.70.71.7-0.70.51.5-0.2-0.21.6-1.5
Saline control response1.62.33.41.61.71.5-1.51.6-1.41.6-1.61.41.41.71.71.2-1.71.81.2-1.3-1.41.3-1.1
Bone: connectivity density0.20.40.70.60.70.7-0.70.8-0.50.7-0.80.90.50.30.50.90.4-0.10.3-0.6-0.60.5-0.3
Bone: cortical apparent density0.91.42.3-1.3-1.1-1.31.3-1.01.5-1.31.0-1.2-1.4-1.2-0.9-1.41.1-1.0-1.41.00.8-1.20.7
Bone: cortical area0.60.92.50.50.51.4-1.41.1-0.41.2-1.20.20.11.21.10.1-0.51.1-0.1-1.6-1.5-0.21.1
Bone: cortical porosity0.60.62.10.90.70.2-0.20.1-1.10.3-0.01.01.20.3-0.01.1-0.50.11.40.30.41.3-1.5
Bone: cortical porosity0.50.62.30.80.60.1-0.10.1-1.00.2-0.00.91.10.3-0.01.1-0.50.11.30.40.41.3-1.5
Bone: cortical thickness0.30.51.1-0.8-0.9-0.50.5-0.70.7-0.50.6-0.9-0.8-0.5-0.7-0.81.0-0.6-0.80.30.4-0.71.0
Bone: cortical thickness0.00.00.10.20.10.0-0.0-0.0-0.30.20.00.00.20.20.10.1-0.20.30.3-0.1-0.00.2-0.1
Bone: cortical tissue density0.91.42.2-1.3-1.1-1.31.3-1.11.5-1.41.1-1.2-1.3-1.2-0.9-1.41.1-1.0-1.41.10.9-1.10.6
Condit. Reinf. active minus inactive responses0.40.52.3-0.1-0.00.6-0.60.60.20.7-0.6-0.4-0.40.50.6-0.4-0.20.6-0.6-1.1-1.0-0.91.5
Condit. Reinf. active-inactive response ratio1.01.12.90.50.71.3-1.31.3-0.31.3-1.40.30.00.91.30.2-0.51.0-0.3-1.7-1.7-0.51.4
Condit. Reinf. active responses0.20.31.5-0.5-0.5-0.00.0-0.10.50.10.1-0.7-0.70.1-0.0-0.70.20.0-0.7-0.4-0.3-1.01.2
Condit. Reinf. inactive responses0.30.40.8-0.6-0.8-0.80.8-0.90.5-0.70.9-0.7-0.5-0.4-0.8-0.60.5-0.6-0.30.70.8-0.40.1
Incentive salience index mean0.30.31.6-0.2-0.10.4-0.40.40.20.6-0.5-0.5-0.40.30.5-0.4-0.10.4-0.5-1.0-0.8-0.91.3
Condit. Reinf. lever presses0.00.00.2-0.00.00.1-0.10.2-0.00.4-0.3-0.1-0.1-0.10.20.0-0.00.1-0.2-0.5-0.4-0.30.1
Condit. Reinf. active minus inactive responses5.38.211.73.03.03.3-3.33.0-2.83.2-3.02.62.63.43.12.3-3.23.42.3-2.8-2.82.0-0.5
Condit. Reinf. active-inactive response ratio0.50.71.30.90.81.1-1.10.7-1.01.1-0.80.60.80.90.80.7-1.11.10.9-0.9-0.80.50.1
Condit. Reinf. active responses9.313.419.53.73.94.2-4.24.0-3.44.1-4.03.23.14.34.22.7-4.14.42.6-3.7-3.82.3-0.7
Condit. Reinf. inactive responses5.27.711.62.83.13.1-3.13.2-2.32.9-3.22.52.23.33.41.9-3.33.41.7-2.7-3.01.8-0.8
Condit. Reinf. lever presses19.328.136.35.96.05.7-5.75.7-5.55.5-5.65.65.45.65.55.1-5.55.54.8-4.4-4.64.5-2.5
Condit. Reinf. lever reinforcers received10.414.620.53.94.14.4-4.44.2-3.64.2-4.23.43.44.54.33.0-4.34.52.9-3.8-3.92.6-0.8
Conditioned reinforcement - actives0.31.32.31.41.21.1-1.11.0-1.51.0-0.91.41.50.90.81.5-1.00.81.5-0.7-0.51.4-0.9
Conditioned reinforcement - inactives0.20.41.4-0.2-0.2-0.50.5-0.60.2-0.90.70.1-0.0-0.8-0.70.00.8-0.80.01.00.90.5-1.2
Conditioned locomotion1.31.95.41.71.30.8-0.80.5-1.80.5-0.41.72.00.80.31.9-1.10.52.30.20.32.3-2.2
Patch foraging indifference point 0 sec3.39.412.13.43.43.5-3.53.3-3.33.3-3.33.23.13.03.13.1-2.92.82.8-2.8-2.72.7-1.8
Patch foraging indifference point AUC0.10.30.90.20.50.6-0.60.8-0.10.7-0.80.2-0.00.50.8-0.0-0.40.7-0.3-0.9-1.0-0.20.4
Delay disc. indifference point, 0s delay0.70.81.91.01.00.8-0.80.8-0.90.6-0.80.80.91.30.90.7-1.41.20.9-0.5-0.70.7-0.5
Delay disc. indifference point, 16s delay0.10.10.2-0.0-0.1-0.50.5-0.20.0-0.30.30.10.1-0.4-0.30.10.4-0.40.10.50.50.0-0.4
Delay disc. indifference point, 2s delay1.11.31.81.31.30.9-0.91.0-1.30.9-1.01.31.31.31.01.2-1.31.11.3-0.6-0.61.2-1.0
Delay disc. indifference point, 24s delay0.60.91.5-1.1-1.0-1.01.0-0.81.2-0.80.8-1.0-1.1-1.2-0.8-1.01.1-0.9-1.20.70.6-1.00.2
Delay disc. indifference point, 4s delay0.40.52.40.60.60.5-0.50.5-0.50.4-0.50.30.50.80.80.1-1.51.40.5-0.4-0.50.3-0.1
Delay disc. indifference point, 8s delay0.20.40.70.70.70.6-0.60.7-0.70.8-0.70.80.70.50.60.8-0.20.20.5-0.5-0.50.6-0.5
Indifference point function ln k0.51.43.81.51.20.7-0.70.6-1.70.7-0.61.61.80.90.41.8-0.90.51.9-0.10.01.8-1.4
Indifference point function log k0.51.43.81.51.20.7-0.70.6-1.70.7-0.61.61.80.90.41.8-0.90.51.9-0.10.01.8-1.4
Patch foraging total patch changes 0 sec2.88.110.43.13.13.2-3.23.1-3.03.0-3.03.02.92.82.92.9-2.72.62.6-2.6-2.52.5-1.8
Patch foraging total patch changes 12 sec2.02.64.81.41.62.1-2.12.1-1.22.0-2.11.10.91.72.01.0-1.51.80.6-2.2-2.20.6-0.1
Patch foraging total patch changes 18 sec1.74.06.21.82.02.5-2.52.4-1.52.3-2.41.51.32.52.41.3-2.22.31.0-2.5-2.50.70.4
Patch foraging total patch changes 24 sec0.20.61.60.70.70.9-0.90.8-0.50.6-0.80.40.51.01.00.3-1.31.20.4-0.8-0.90.2-0.2
Patch foraging total patch changes 6 sec1.72.94.31.91.92.1-2.11.8-1.81.7-1.81.91.81.71.61.9-1.11.21.6-1.5-1.41.6-1.0
Patch foraging time to switch 0 sec1.87.09.0-2.8-2.9-3.03.0-3.02.6-2.93.0-2.5-2.4-2.8-2.9-2.32.8-2.9-2.12.72.6-1.80.9
Patch foraging water rate 0 sec1.55.77.12.62.62.7-2.72.5-2.52.5-2.42.32.42.52.42.3-2.72.52.3-2.1-2.01.9-1.3
Patch foraging water rate 12 sec0.62.63.91.91.71.6-1.61.5-1.91.5-1.41.71.91.81.31.8-2.01.51.9-1.2-1.01.6-1.0
Patch foraging water rate 18 sec0.30.71.40.90.90.9-0.90.9-0.80.9-0.90.70.81.01.00.7-1.21.00.7-0.9-0.90.4-0.3
Patch foraging water rate 24 sec0.71.02.71.20.90.8-0.80.5-1.40.7-0.51.21.50.70.31.5-0.90.31.6-0.3-0.01.3-1.2
Patch foraging water rate 6 sec0.60.81.71.11.00.7-0.70.8-1.20.7-0.71.21.20.80.51.3-0.70.41.2-0.4-0.31.2-1.3
Seeking ratio, delayed vs. immediate footshock2.02.83.9-1.9-2.0-1.51.5-1.91.8-1.91.9-1.8-1.7-1.6-1.8-1.71.6-1.6-1.51.51.6-1.41.3
Distance traveled before self-admin0.10.30.7-0.7-0.6-0.50.5-0.50.7-0.50.5-0.5-0.7-0.7-0.5-0.60.8-0.7-0.70.30.4-0.50.4
Distance traveled after self-admin1.12.04.1-1.0-1.2-1.71.7-1.80.8-1.71.8-0.7-0.6-1.6-1.8-0.61.5-1.7-0.32.02.0-0.1-0.8
Extensor digitorum longus weight0.21.03.2-0.6-0.20.4-0.40.70.80.7-0.8-0.9-1.10.30.9-1.00.00.8-1.4-1.4-1.4-1.61.8
Bone: elastic displacement1.21.52.9-1.2-1.4-1.21.2-1.41.1-1.31.4-1.1-1.0-1.2-1.5-0.91.7-1.5-0.91.21.3-0.80.6
Bone: elastic work1.41.94.6-1.3-1.4-1.51.5-1.51.1-1.51.5-0.9-1.0-1.6-1.7-0.82.1-1.9-0.91.51.5-0.70.1
Bone: endosteal estimation1.33.27.01.31.62.2-2.22.3-1.02.2-2.30.90.71.92.40.7-1.82.20.2-2.6-2.60.10.5
Bone: endosteal perimeter2.05.08.21.92.22.8-2.82.7-1.62.6-2.81.61.32.52.81.3-2.62.70.9-2.8-2.90.8-0.0
Epididymis fat weight0.41.94.5-1.7-1.8-0.80.8-1.21.5-0.91.1-2.0-1.7-1.0-1.0-1.80.9-0.6-1.60.20.4-1.92.1
Delta time in closed arm before/after self-admin0.80.82.3-1.0-0.7-0.40.4-0.21.3-0.30.1-1.0-1.3-0.3-0.0-1.20.6-0.2-1.5-0.2-0.3-1.41.5
Delta time in open arm before/after self-admin2.42.94.01.71.82.0-2.02.0-1.51.9-2.01.51.41.92.01.3-1.81.91.1-1.9-1.91.1-0.1
Diff in mean of infusions in LGA sessions4.07.39.5-2.9-3.0-3.03.0-3.12.7-2.93.1-2.7-2.5-2.9-2.9-2.52.7-2.7-2.22.62.7-2.11.0
Delay discount exponential model param0.00.10.3-0.3-0.30.0-0.0-0.10.3-0.10.1-0.4-0.4-0.1-0.1-0.30.2-0.2-0.4-0.1-0.1-0.30.6
Extinction: sum of active levers before priming0.00.10.3-0.00.00.1-0.10.00.1-0.0-0.1-0.2-0.10.30.2-0.3-0.60.6-0.1-0.1-0.2-0.20.4
Active lever presses in extinction session 62.52.510.71.81.40.4-0.40.4-2.10.4-0.32.02.30.30.12.2-0.70.12.50.60.72.6-3.3
Bone: final force0.10.10.20.30.40.5-0.50.4-0.20.3-0.40.50.20.30.30.30.50.00.1-0.2-0.30.40.1
Bone: final moment0.20.30.50.50.60.7-0.70.7-0.40.5-0.70.60.30.50.50.40.20.20.1-0.5-0.60.40.1
Food consumed during 24 hour testing period1.63.15.62.12.21.4-1.41.7-1.91.4-1.62.22.01.41.62.0-1.91.31.9-0.8-1.02.2-2.4
Glucose0.10.10.8-0.2-0.30.1-0.1-0.20.2-0.10.2-0.4-0.30.0-0.1-0.4-0.20.3-0.2-0.1-0.0-0.50.9
Heart weight0.71.21.91.21.11.4-1.41.2-1.21.3-1.21.11.10.91.01.2-0.80.81.0-1.1-1.01.0-0.6
Delay discount hyperbolic model param0.10.10.2-0.4-0.4-0.20.2-0.30.3-0.20.3-0.4-0.4-0.3-0.3-0.30.5-0.4-0.40.10.1-0.30.4
Intermittent access intake day 1-15 change0.42.24.31.91.71.2-1.21.2-1.81.0-1.12.02.01.31.01.9-1.20.81.9-0.4-0.42.1-1.8
Intermittent access intake escalation0.52.54.82.01.91.3-1.31.3-2.01.1-1.22.22.11.31.12.0-1.20.92.1-0.4-0.52.2-1.9
Intermittent access intake escalation 21.01.62.61.51.51.2-1.21.2-1.51.1-1.11.61.61.01.01.6-1.00.81.5-0.7-0.61.5-1.3
Intermitt. access day 1 inactive lever presses0.22.84.6-1.6-1.6-2.12.1-1.81.6-1.81.8-1.3-1.4-2.1-1.7-1.31.9-1.8-1.31.91.7-1.0-0.4
Intermitt. access day 15 inactive lever presses0.52.74.4-1.6-1.7-2.02.0-1.91.4-1.81.9-1.3-1.3-2.1-1.9-1.21.9-2.0-1.11.71.8-0.8-0.1
Intermitt. access escalation Index0.00.10.5-0.10.0-0.10.10.10.10.1-0.10.2-0.1-0.4-0.10.20.7-0.5-0.20.00.0-0.0-0.3
Intermittent access day 1 total infusions0.20.71.01.01.00.9-0.91.0-0.90.9-0.91.00.90.70.81.0-0.70.70.8-0.7-0.70.8-0.6
Intermittent access day 15 total infusions1.12.74.92.02.01.4-1.41.4-2.01.2-1.42.22.11.41.22.1-1.31.02.0-0.6-0.72.2-1.8
Intermittent access terminal intake (last 3 days)1.62.94.42.02.01.8-1.81.7-1.91.5-1.62.12.01.61.42.0-1.31.21.9-1.1-1.11.9-1.3
Intermittent access total infusions1.41.72.41.41.41.5-1.51.4-1.31.3-1.41.41.31.21.31.3-1.11.11.1-1.2-1.21.1-0.6
Intermittent access day 1 locomotion0.10.20.70.50.50.2-0.20.3-0.60.3-0.30.70.60.00.10.70.1-0.10.6-0.1-0.00.7-0.8
Intermittent access day 15 total locomotion0.51.83.71.71.51.0-1.00.9-1.70.9-0.91.81.81.10.71.8-1.00.71.9-0.3-0.31.9-1.6
Intermittent access total locomotion0.81.01.41.21.11.1-1.10.9-1.10.9-0.91.21.20.90.81.2-0.80.71.1-0.6-0.61.2-0.7
Intermittent access standard deviation0.10.51.20.40.51.0-1.00.8-0.20.8-0.90.10.10.71.00.0-0.91.0-0.1-1.1-1.1-0.20.2
Left kidney weight0.11.22.9-0.10.20.8-0.80.90.41.0-1.0-0.7-0.71.11.4-0.9-1.41.6-0.9-1.7-1.7-1.21.5
Right kidney weight0.21.64.30.10.41.1-1.11.30.31.2-1.3-0.5-0.61.21.7-0.8-1.61.9-0.9-2.0-2.1-1.21.4
Cocaine induced anxiety0.61.72.4-1.6-1.5-1.21.2-1.21.5-1.01.1-1.5-1.6-1.4-1.1-1.41.5-1.3-1.50.60.7-1.51.1
Post-drug Anxiety1.21.42.0-1.4-1.3-1.11.1-1.01.4-1.11.0-1.3-1.4-1.3-1.0-1.31.4-1.1-1.40.70.7-1.20.8
Baseline Anxiety0.20.30.50.60.70.6-0.60.6-0.50.5-0.60.60.50.70.60.5-0.50.60.4-0.4-0.50.4-0.3
Tail length0.63.49.20.00.61.8-1.81.90.51.8-2.0-0.8-0.92.02.3-1.0-2.02.5-1.3-3.0-3.0-1.92.0
Length with tail0.52.15.7-0.00.31.3-1.31.40.31.5-1.5-0.7-0.71.61.8-0.9-1.42.0-1.0-2.4-2.3-1.62.1
Length without tail0.10.40.8-0.7-0.7-0.90.9-0.80.7-0.80.8-0.7-0.6-0.5-0.6-0.80.5-0.4-0.50.70.6-0.40.4
Times rat made contact with spout0.30.41.4-0.7-0.4-0.20.20.10.9-0.1-0.1-0.7-1.00.00.2-0.90.2-0.0-1.2-0.5-0.5-1.00.9
Lifetime Intake1.61.92.61.61.61.6-1.61.5-1.51.4-1.41.61.51.31.31.6-1.21.11.4-1.1-1.11.3-0.9
Liver weight, left0.30.51.5-0.7-0.4-0.30.3-0.00.9-0.0-0.1-1.0-1.0-0.00.4-1.2-0.40.7-1.1-0.5-0.6-1.20.8
Liver weight, right1.62.77.4-1.9-1.5-1.11.1-0.82.3-1.00.7-2.4-2.4-0.4-0.2-2.70.20.4-2.5-0.1-0.3-2.62.5
Locomotor activity0.91.42.21.11.21.5-1.51.3-1.01.3-1.31.01.01.21.30.9-1.51.10.8-1.4-1.30.7-0.3
Locomotor testing distance1.22.95.51.41.52.2-2.21.9-1.32.0-1.90.91.02.02.00.9-2.22.20.8-2.4-2.10.50.4
Locomotor testing rearing0.31.23.60.40.51.3-1.31.2-0.21.3-1.2-0.1-0.11.21.3-0.1-1.21.5-0.2-1.9-1.7-0.61.2
Locomotion in novel chamber0.70.92.21.21.00.6-0.60.6-1.30.7-0.61.21.30.60.51.3-0.90.61.4-0.3-0.21.3-1.5
Locomotion in novel chamber post-restriction1.33.88.92.42.11.3-1.31.5-2.51.5-1.42.42.61.51.22.5-1.71.22.7-0.7-0.62.6-3.0
Fecal boli incidents, locomotor time 10.20.61.31.00.90.5-0.50.5-1.00.5-0.51.11.10.70.41.0-0.50.31.1-0.1-0.11.1-0.7
Change in fecal boli incidents, locomotor task0.60.71.1-0.8-0.8-1.01.0-0.90.8-0.90.9-0.8-0.7-1.0-0.9-0.70.8-0.8-0.60.80.8-0.6-0.0
Time >=10cm from walls, locomotor time 11.41.73.61.61.40.9-0.91.0-1.81.0-1.01.71.81.20.71.9-1.00.71.9-0.4-0.41.6-1.6
Bouts of movement, locomotor time 10.00.00.20.20.2-0.20.2-0.0-0.2-0.10.00.10.20.20.10.1-0.50.40.30.30.10.1-0.1
Total resting periods, locomotor time 10.10.10.50.0-0.0-0.50.5-0.4-0.1-0.40.40.10.2-0.2-0.30.1-0.1-0.10.30.70.50.1-0.4
Rest time, locomotor task time 10.40.71.7-0.3-0.4-1.21.2-1.00.3-0.91.0-0.2-0.1-1.1-0.8-0.20.3-0.60.11.31.20.1-1.3
Distance moved, locomotor task time 10.41.13.00.40.51.3-1.31.2-0.21.2-1.30.1-0.11.51.2-0.0-0.71.1-0.3-1.7-1.7-0.41.6
Vertical activity count, locomotor time 10.21.53.70.80.91.7-1.71.5-0.81.6-1.60.70.51.51.40.6-0.81.10.2-1.9-1.80.30.6
Time >=10cm from walls, locomotor time 20.30.82.01.00.90.9-0.90.8-1.00.8-0.80.81.01.30.90.7-1.41.21.0-0.6-0.70.6-0.6
Bouts of movement, locomotor time 20.20.61.70.80.90.7-0.70.7-0.70.6-0.70.60.71.00.90.5-1.31.20.7-0.5-0.70.30.3
Total resting periods, locomotor time 20.10.31.00.60.60.4-0.40.4-0.50.3-0.40.40.60.70.60.4-1.00.90.6-0.1-0.30.30.4
Rest time, locomotor task time 21.22.12.8-1.6-1.5-1.71.7-1.51.6-1.61.5-1.3-1.4-1.3-1.4-1.41.6-1.5-1.41.41.3-1.20.9
Distance moved, locomotor task time 21.92.54.11.61.61.8-1.81.7-1.51.8-1.71.21.41.91.81.2-2.01.91.2-1.8-1.71.0-0.4
Vertical activity count, locomotor time 20.81.83.61.11.21.8-1.81.6-1.01.7-1.60.80.81.51.60.8-1.41.50.6-1.9-1.70.40.0
Light reinforcement 10.52.23.4-1.7-1.6-1.61.6-1.51.8-1.51.4-1.6-1.8-1.4-1.2-1.81.5-1.1-1.71.21.0-1.41.0
Light reinforcement 20.10.20.70.00.0-0.50.5-0.40.0-0.40.40.20.1-0.3-0.2-0.00.2-0.10.20.80.60.5-0.8
Bone: marrow area1.22.96.41.11.52.1-2.12.2-0.82.1-2.20.80.61.72.30.5-1.72.10.1-2.5-2.50.00.5
Bone: maximum diameter2.34.77.91.92.12.8-2.82.6-1.72.6-2.71.61.42.52.61.4-2.12.51.0-2.7-2.70.90.2
Bone: maximum force0.20.30.80.60.70.6-0.60.8-0.50.7-0.80.90.50.30.60.70.50.10.3-0.4-0.50.7-0.4
Bone: maximum moment0.30.51.00.70.90.9-0.91.0-0.60.9-1.01.00.60.40.80.80.20.30.3-0.7-0.80.7-0.4
Mean time between licks in bursts0.84.88.72.02.32.3-2.32.6-1.52.4-2.71.61.42.63.01.1-2.92.90.9-2.4-2.70.8-0.2
Mean num. licks in bursts1.54.05.02.22.22.1-2.12.1-2.22.2-2.12.12.12.01.92.1-2.11.82.0-1.8-1.71.6-1.0
Cd content in liver0.70.83.6-1.0-1.0-0.50.5-0.51.0-0.20.4-1.2-1.2-0.2-0.3-1.20.6-0.1-1.2-0.2-0.1-1.41.9
Co content in liver0.70.91.90.60.81.1-1.11.2-0.51.2-1.20.40.41.11.20.3-1.11.20.2-1.4-1.4-0.10.7
Cu content in liver0.30.41.0-0.3-0.20.3-0.30.20.60.2-0.3-0.8-0.70.50.6-0.9-0.91.0-0.8-0.7-0.8-0.90.7
Fe content in liver0.00.00.3-0.1-0.2-0.30.3-0.20.1-0.10.2-0.1-0.1-0.0-0.2-0.10.3-0.0-0.10.20.20.2-0.5
K content in liver0.10.10.3-0.4-0.3-0.30.3-0.20.5-0.30.2-0.3-0.4-0.6-0.2-0.40.2-0.2-0.50.20.2-0.4-0.0
Mg content in liver0.10.10.30.30.20.0-0.00.0-0.3-0.00.00.30.4-0.10.00.3-0.40.20.40.20.20.3-0.5
Mn content in liver1.31.53.5-0.7-0.9-1.41.4-1.50.5-1.51.5-0.3-0.3-1.6-1.5-0.31.3-1.5-0.01.91.80.2-1.3
Na content in liver0.80.92.11.11.00.7-0.70.6-1.10.5-0.51.31.30.50.51.2-0.60.41.3-0.0-0.01.4-1.4
Rb content in liver0.30.31.20.30.40.7-0.70.8-0.31.0-0.80.20.10.50.60.3-0.30.5-0.0-1.1-0.9-0.10.5
Se content in liver6.67.911.0-2.7-2.9-3.33.3-3.32.5-3.23.3-2.4-2.3-3.3-3.2-2.33.1-2.9-1.93.23.2-1.60.0
Sr content in liver0.10.10.30.40.20.2-0.20.1-0.50.2-0.10.40.50.4-0.10.50.0-0.10.6-0.00.10.4-0.2
Zn content in liver1.82.14.41.21.31.7-1.71.6-1.11.7-1.60.80.91.81.70.7-2.12.00.8-1.8-1.70.40.5
Bone: minimum diameter0.91.85.00.20.51.5-1.51.50.21.4-1.6-0.2-0.51.31.7-0.5-1.01.6-0.9-2.2-2.2-1.01.8
Time in familiar zone, hab. session 10.10.10.3-0.4-0.2-0.40.4-0.10.5-0.20.1-0.3-0.5-0.30.0-0.40.2-0.0-0.60.1-0.0-0.50.2
Time in novel zone, hab. session 10.10.10.9-0.2-0.30.2-0.2-0.10.2-0.10.1-0.4-0.30.1-0.1-0.40.10.0-0.3-0.2-0.1-0.40.9
Total zone transitions, hab. session 10.20.31.20.60.50.2-0.20.1-0.70.1-0.10.90.80.2-0.10.90.3-0.30.90.30.41.1-0.6
Total locomotion distance, hab. session 10.91.33.6-1.4-1.2-0.70.7-0.61.5-0.50.5-1.6-1.6-0.6-0.4-1.60.8-0.4-1.7-0.1-0.1-1.71.9
Locomotion velocity, hab. session 10.50.82.4-1.1-0.9-0.40.4-0.41.1-0.30.4-1.2-1.3-0.5-0.2-1.30.7-0.3-1.3-0.2-0.2-1.31.5
Time in familiar zone, hab. session 21.51.73.01.11.31.5-1.51.7-0.91.6-1.71.00.81.41.60.9-1.41.30.5-1.7-1.70.40.1
Time in novel zone, hab. session 20.60.71.6-0.6-0.9-1.01.0-1.30.4-1.11.3-0.7-0.3-0.8-1.1-0.60.6-0.5-0.01.21.3-0.1-0.0
Total zone transitions, hab. session 21.11.43.81.41.20.7-0.70.6-1.60.9-0.61.61.70.60.51.7-0.50.41.7-0.00.01.9-1.9
Total locomotion distance, hab. session 20.20.31.0-0.6-0.40.0-0.00.10.70.2-0.1-0.7-0.8-0.20.4-0.90.20.3-1.0-0.5-0.6-0.80.6
Locomotion velocity, hab. session 20.30.41.3-0.7-0.5-0.10.1-0.00.80.1-0.0-0.9-1.0-0.30.3-1.10.20.3-1.2-0.5-0.5-1.00.6
Novel to familiar place preference ratio0.10.10.90.30.20.1-0.1-0.1-0.4-0.00.10.30.40.3-0.00.3-0.10.20.50.30.20.5-1.0
Novelty place preference0.10.10.70.20.1-0.10.1-0.2-0.2-0.20.20.10.30.1-0.10.1-0.20.20.40.40.30.4-0.8
Time in novel zone, NPP test0.10.10.70.40.30.1-0.1-0.0-0.40.00.00.30.50.30.00.3-0.30.30.60.20.20.5-0.8
Total zone transitions, NPP test0.20.31.80.40.3-0.20.2-0.2-0.5-0.20.30.60.7-0.5-0.30.60.1-0.30.70.70.71.0-1.3
Total locomotion distance, NPP test1.11.53.2-1.5-1.4-1.11.1-1.21.5-1.11.1-1.6-1.5-1.3-0.7-1.80.8-0.4-1.50.70.6-1.40.9
Locomotion velocity, NPP test1.62.24.3-1.8-1.7-1.41.4-1.51.8-1.41.5-2.0-1.8-1.6-1.0-2.11.0-0.7-1.81.00.9-1.60.9
Intraocular pressure0.40.71.91.00.70.6-0.60.3-1.20.4-0.31.11.20.60.01.2-0.20.01.40.00.21.4-1.1
Delta distance traveled before/after self-admin0.50.52.20.70.5-0.10.1-0.1-0.9-0.00.10.91.00.1-0.21.0-0.2-0.21.20.60.61.2-1.5
Delta ambulatory time before/after self-admin0.30.62.60.70.4-0.10.1-0.2-0.9-0.10.20.91.00.1-0.31.0-0.1-0.31.20.70.71.3-1.6
Parametrial fat weight0.20.41.2-0.8-0.7-0.40.4-0.40.9-0.60.4-0.8-0.9-0.1-0.3-0.90.5-0.1-0.90.20.1-0.91.1
Pavlov. Cond. lever latency0.91.11.9-1.0-1.2-1.21.2-1.40.9-1.31.4-1.0-0.8-0.8-1.3-0.91.1-1.0-0.61.31.3-0.60.3
Pavlov. Cond. magazine entry latency2.93.85.92.02.12.2-2.22.3-1.92.4-2.31.81.61.92.21.7-1.82.11.4-2.2-2.21.2-0.5
Pavlov. Cond. change in total contacts0.50.60.90.80.80.8-0.80.8-0.80.9-0.80.70.70.50.90.7-0.70.90.6-0.7-0.70.6-0.6
Pavlov. Cond. index score2.02.64.31.51.71.8-1.82.0-1.42.1-2.01.31.21.52.01.2-1.71.80.9-2.0-2.00.7-0.2
Pavlov. Cond. latency score2.02.54.21.51.71.8-1.82.0-1.42.1-2.01.31.21.41.91.3-1.61.70.9-1.9-1.90.8-0.3
Pavlov. Cond. lever contacts0.70.81.60.70.91.0-1.01.2-0.61.2-1.20.60.50.61.20.6-0.90.90.3-1.3-1.30.20.0
Pavlov. Cond. magazine entry number2.83.55.5-1.9-2.0-2.12.1-2.21.8-2.32.2-1.6-1.5-2.0-2.1-1.61.9-2.0-1.32.12.1-1.10.2
Pavlov. Cond. intertrial magazine entries2.42.94.3-1.8-2.0-1.81.8-2.11.7-2.02.0-1.9-1.6-1.7-1.8-1.81.2-1.5-1.31.71.7-1.60.5
Pavlov. Cond. lever-magazine prob. diff.1.72.13.51.31.51.6-1.61.8-1.21.9-1.91.21.01.31.81.1-1.51.50.7-1.8-1.80.6-0.2
Pavlov. Cond. response bias0.81.01.90.91.11.1-1.11.3-0.81.4-1.30.80.70.81.30.7-1.01.10.4-1.3-1.30.4-0.1
Pavlov. Cond. lever latency20.528.837.3-6.1-6.1-5.65.6-5.65.8-5.65.5-5.8-5.7-5.5-5.4-5.45.5-5.4-5.24.24.4-5.03.1
Pavlov. Cond. magazine entry latency4.96.910.03.13.02.6-2.62.6-3.22.7-2.63.13.12.52.33.1-2.22.12.9-1.9-1.82.7-1.7
Pavlov. Cond. change in total contacts7.518.223.44.84.74.5-4.54.2-4.84.5-4.24.54.64.54.14.3-4.64.44.4-3.3-3.33.9-2.5
Pavlov. Cond. index score13.320.926.95.25.14.8-4.84.7-5.14.8-4.64.94.94.64.44.8-4.64.54.6-3.6-3.64.2-2.6
Pavlov. Cond. latency score11.518.524.34.94.94.4-4.44.4-4.94.5-4.34.74.74.34.14.6-4.34.14.4-3.3-3.34.1-2.6
Pavlov. Cond. lever contacts18.427.234.85.95.95.5-5.55.5-5.75.5-5.45.65.55.45.25.3-5.45.25.0-4.2-4.34.7-2.9
Pavlov. Cond. magazine entry number6.68.612.7-3.4-3.2-3.03.0-2.83.6-3.12.7-3.2-3.4-2.8-2.6-3.32.9-2.7-3.32.22.0-2.91.8
Pavlov. Cond. intertrial magazine entries0.30.61.6-0.20.10.6-0.60.60.60.3-0.6-0.5-0.70.80.9-0.8-0.60.9-0.9-0.9-1.1-0.91.3
Pavlov. Cond. lever-magazine prob. diff.12.519.224.65.04.94.6-4.64.5-4.94.7-4.54.74.74.44.34.5-4.54.44.4-3.5-3.54.0-2.4
Pavlov. Cond. response bias19.827.434.65.95.95.5-5.55.5-5.75.6-5.45.65.55.45.25.3-5.35.25.1-4.3-4.34.7-2.8
Time in closed arm before self-admin0.40.71.81.00.70.4-0.40.4-1.20.5-0.31.01.20.30.11.3-0.40.11.30.00.11.3-1.3
Time in closed arm after self-admin0.91.02.1-0.8-0.8-1.31.3-1.10.8-1.31.2-0.5-0.6-1.1-1.2-0.51.3-1.3-0.51.41.3-0.3-0.3
Time in open arm before self-admin1.92.33.0-1.7-1.7-1.51.5-1.71.6-1.61.7-1.6-1.6-1.6-1.5-1.61.4-1.4-1.41.31.4-1.30.7
Time in open arm after self-admin0.80.92.60.50.71.3-1.31.2-0.41.2-1.20.30.20.91.20.2-0.91.1-0.1-1.6-1.5-0.20.7
Bone: periosteal estimation1.33.06.71.21.42.3-2.32.2-0.92.1-2.20.80.61.92.20.6-1.62.20.2-2.6-2.50.10.8
Bone: periosteal perimeter1.73.46.71.41.72.4-2.42.3-1.12.2-2.41.10.82.12.30.8-1.92.10.4-2.6-2.60.30.6
Bone: post-yield work0.40.81.70.81.01.0-1.01.3-0.61.1-1.31.00.60.61.00.8-0.10.50.3-1.1-1.10.40.0
Progressive ratio test 1 active lever presses0.10.20.60.0-0.1-0.40.4-0.4-0.1-0.50.50.20.2-0.4-0.60.30.6-0.70.30.70.70.5-0.5
Progressive ratio test 1 breakpoint0.10.20.50.0-0.1-0.40.4-0.4-0.1-0.50.50.20.2-0.3-0.60.20.5-0.70.30.70.70.5-0.4
Progressive ratio test 1 inactive lever presses0.10.41.2-0.4-0.4-0.80.8-0.50.3-0.60.6-0.0-0.2-0.8-0.70.01.1-1.1-0.20.80.80.2-0.6
Progressive ratio test 2 active lever presses0.50.71.10.90.91.0-1.00.9-0.90.8-0.90.80.81.00.80.8-1.00.90.8-0.8-0.80.7-0.1
Progressive ratio test 2 breakpoint0.60.71.10.90.91.0-1.00.9-0.90.8-0.90.80.91.00.80.8-1.00.90.8-0.8-0.70.7-0.1
Progressive ratio test 2 inactive lever presses0.10.20.40.50.40.6-0.60.5-0.50.5-0.50.50.50.50.40.5-0.40.30.5-0.5-0.40.4-0.0
Incentive Sensitization - Responses0.71.93.11.41.41.8-1.81.5-1.31.5-1.51.11.21.71.51.1-1.51.51.0-1.6-1.40.9-0.1
Incentive Sensitization - Breakpoint0.81.72.81.31.31.7-1.71.4-1.21.4-1.41.11.11.61.41.1-1.51.41.0-1.5-1.30.8-0.2
Sum of active levers in priming session hrs 5-60.10.10.40.10.1-0.30.3-0.2-0.1-0.10.20.10.2-0.1-0.00.0-0.50.30.30.30.20.2-0.6
Progressive ratio0.10.41.20.70.60.4-0.40.4-0.80.5-0.30.90.80.10.20.9-0.20.00.9-0.1-0.01.1-1.1
Food seeking constrained by brief footshock2.22.84.61.71.91.8-1.81.9-1.41.6-1.91.51.42.02.01.2-2.12.11.2-1.5-1.71.0-0.6
Seeking ratio, punishment vs. effort0.51.02.40.60.81.1-1.11.2-0.31.0-1.20.30.21.51.40.0-1.41.5-0.0-1.3-1.5-0.30.8
Retroperitoneal fat weight1.87.927.9-3.2-2.8-0.90.9-1.13.6-1.00.9-4.0-4.0-0.8-0.4-4.20.90.2-4.2-1.1-1.0-4.85.3
Reaction time number correct0.10.42.10.40.2-0.30.3-0.4-0.5-0.30.40.70.7-0.3-0.50.80.3-0.60.90.80.91.0-1.4
Reaction time mean minus median0.32.03.01.31.51.6-1.61.7-1.11.6-1.71.11.01.61.70.9-1.61.70.8-1.6-1.70.60.1
Reaction time mean minus median AUC0.32.02.71.61.61.5-1.51.6-1.41.5-1.61.51.41.51.61.3-1.61.51.2-1.3-1.41.1-0.5
Reaction time num false alarms1.62.74.3-2.0-1.9-1.31.3-1.42.0-1.31.4-1.9-2.0-1.8-1.2-2.01.8-1.3-2.10.80.8-1.91.4
Reaction time num false alarms AUC0.81.72.6-1.5-1.5-1.21.2-1.31.5-1.21.2-1.5-1.5-1.6-1.1-1.51.4-1.2-1.50.80.9-1.30.7
Reaction time trials correct on left0.10.42.10.40.2-0.30.3-0.4-0.5-0.30.40.70.7-0.3-0.50.80.3-0.60.90.80.91.0-1.4
Reaction time trials on left0.10.52.20.40.2-0.30.3-0.3-0.6-0.30.40.70.8-0.3-0.50.80.2-0.60.90.80.91.1-1.5
Reaction time mean0.10.20.6-0.5-0.3-0.10.1-0.00.7-0.30.0-0.6-0.7-0.30.1-0.70.20.3-0.8-0.1-0.2-0.80.6
Reaction time mean AUC0.20.51.0-0.8-0.6-0.60.6-0.51.0-0.70.5-0.9-0.9-0.7-0.3-1.00.5-0.1-1.00.40.2-0.90.5
Median of all reaction times0.40.61.2-0.9-0.8-0.70.7-0.61.1-0.80.6-0.9-1.0-0.9-0.4-1.10.7-0.3-1.10.40.3-1.00.4
Reaction time omissions0.10.10.80.20.30.4-0.40.3-0.10.3-0.4-0.00.00.50.6-0.2-0.50.9-0.0-0.4-0.50.00.2
Reaction time false alarm rate1.41.93.5-1.7-1.6-1.11.1-1.11.7-1.11.1-1.7-1.8-1.5-0.9-1.81.3-0.9-1.90.50.5-1.71.3
Reaction time premature initiation rate2.13.38.21.11.42.2-2.22.3-0.82.3-2.40.60.42.12.40.5-1.62.2-0.0-2.9-2.9-0.31.4
Reaction time premature initiations0.82.65.01.31.51.9-1.92.0-1.22.0-2.11.00.91.92.01.0-1.41.80.6-2.2-2.20.40.5
Std. dev. reaction times0.31.12.50.60.81.2-1.21.3-0.31.1-1.30.20.21.11.40.1-1.21.5-0.1-1.5-1.6-0.30.9
Reaction time trials completed0.10.52.20.40.2-0.30.3-0.3-0.6-0.30.40.70.8-0.3-0.50.80.2-0.60.90.80.91.1-1.5
Reaction time trials AUC0.10.41.80.50.3-0.10.1-0.2-0.6-0.20.30.70.7-0.1-0.30.70.1-0.40.90.70.71.0-1.3
Run reversals in cocaine runway, females1.11.24.0-0.8-0.40.5-0.50.61.10.5-0.7-1.1-1.40.30.8-1.3-0.10.6-1.8-1.4-1.4-1.92.0
Run reversals in cocaine runway, males0.00.00.10.20.3-0.10.10.1-0.0-0.1-0.10.40.2-0.10.10.20.1-0.10.10.20.10.3-0.1
Latency to leave start box in cocaine runway2.02.74.6-1.8-1.8-1.81.8-1.71.8-1.71.7-1.7-1.8-2.2-1.5-1.71.6-1.5-1.71.51.4-1.50.2
Latency to leave start box in cocaine runway, F2.02.54.0-1.9-1.7-1.61.6-1.42.0-1.41.4-1.8-1.9-1.8-1.2-2.01.4-1.1-1.91.00.9-1.70.8
Latency to leave start box in cocaine runway, M0.50.41.2-0.4-0.5-0.80.8-0.80.3-0.70.8-0.3-0.2-1.1-0.8-0.10.7-0.8-0.10.90.9-0.1-0.8
Std. dev. time between licks in bursts0.71.33.10.71.01.2-1.21.4-0.41.3-1.50.40.21.31.70.1-1.51.6-0.1-1.6-1.8-0.20.5
Total sessions with >9 infusions1.92.33.21.81.71.6-1.61.6-1.71.5-1.61.81.71.31.41.8-1.31.11.5-1.2-1.11.6-1.2
Short access day 1 total inactive lever presses0.00.00.40.10.20.1-0.1-0.0-0.0-0.20.00.10.10.10.10.1-0.20.20.10.10.10.2-0.7
Short access day 10 total inactive lever presses0.21.62.6-1.3-1.4-1.41.4-1.41.2-1.31.4-1.2-1.2-1.6-1.4-1.01.6-1.5-1.11.21.2-0.9-0.0
Short access day 1 total infusions1.93.75.12.02.12.2-2.22.1-1.92.0-2.11.91.82.02.11.8-2.02.01.6-1.9-1.81.4-0.7
Short access day 10 total infusions0.71.11.41.21.21.1-1.11.2-1.11.1-1.11.11.10.81.11.1-0.90.91.0-1.0-0.90.9-0.8
Short access total infusions1.62.22.91.71.71.6-1.61.5-1.71.4-1.51.71.71.31.41.7-1.31.21.5-1.1-1.11.5-1.3
Short access day 1 locomotion2.03.45.92.22.11.7-1.71.7-2.31.6-1.62.42.41.51.32.4-1.31.02.3-0.9-0.92.4-1.8
Short access day 10 total locomotion0.41.72.31.51.51.2-1.21.3-1.51.4-1.31.41.51.21.31.4-1.31.21.4-1.0-1.01.4-1.1
Short access total locomotion0.71.12.31.31.20.9-0.90.9-1.30.8-0.81.41.40.60.61.5-0.50.41.4-0.4-0.41.5-1.4
One hour access (0.3 mA shock)1.01.21.61.21.11.3-1.31.1-1.31.2-1.11.01.21.11.01.2-1.11.01.1-1.1-0.90.9-0.3
Compulsive drug intake0.50.71.8-0.4-0.7-1.01.0-1.10.1-0.91.1-0.2-0.0-0.9-1.20.00.8-1.10.31.31.40.3-0.5
One hour access (shock baseline)0.71.92.51.61.61.5-1.51.5-1.51.4-1.41.51.51.31.31.5-1.41.31.4-1.1-1.11.3-0.8
Social response proportion0.50.61.1-0.9-0.8-0.90.9-0.61.0-0.70.6-0.9-1.0-0.8-0.4-1.10.6-0.4-1.00.50.4-1.00.4
Social responses0.70.92.7-1.2-1.0-0.50.5-0.51.4-0.50.4-1.4-1.5-0.6-0.2-1.50.5-0.2-1.6-0.1-0.2-1.61.0
Social time3.04.87.1-2.2-2.4-2.62.6-2.72.0-2.52.6-2.1-1.8-2.4-2.5-1.92.1-2.1-1.52.42.4-1.30.1
Soleus weight0.51.43.8-0.8-0.30.4-0.40.81.20.6-0.9-1.2-1.50.11.1-1.5-0.20.8-2.0-1.6-1.7-1.91.6
Bone: stiffness0.10.11.1-0.10.0-0.20.20.10.3-0.2-0.10.2-0.2-0.30.0-0.11.0-0.4-0.50.30.00.2-0.1
Tibialis anterior weight0.20.51.50.30.60.8-0.81.0-0.21.0-1.00.20.00.71.10.1-0.51.0-0.2-1.2-1.2-0.30.3
Time to tail flick, vehicle, before self-admin0.20.20.70.10.10.5-0.50.5-0.10.6-0.6-0.0-0.10.40.40.10.00.1-0.2-0.8-0.7-0.30.8
Time to tail flick, vehicle, after self-admin0.81.62.11.41.41.4-1.41.5-1.31.4-1.41.31.21.21.31.3-1.11.11.1-1.2-1.21.1-0.6
Time to tail flick, test, before self-admin0.50.61.60.20.40.8-0.80.9-0.00.9-1.00.0-0.11.01.0-0.1-0.70.9-0.4-1.3-1.3-0.51.2
Time to tail flick, test, after self-admin0.30.30.7-0.1-0.00.3-0.30.40.30.3-0.4-0.5-0.40.50.6-0.5-0.70.8-0.5-0.8-0.8-0.80.7
Delta time to tail flick, vehicle, before/after SA1.11.22.21.31.20.8-0.80.9-1.30.8-0.81.41.40.90.71.4-0.90.71.4-0.4-0.41.5-1.4
Delta time to tail flick, test, before/after SA0.50.61.1-0.7-0.8-1.01.0-1.00.6-1.01.0-0.6-0.5-1.1-0.9-0.50.6-0.7-0.31.01.0-0.3-0.5
Tibia length1.33.56.92.31.91.7-1.71.4-2.61.8-1.32.22.51.71.02.5-1.41.02.6-1.0-0.72.3-1.8
Ambulatory time before self-admin0.20.81.3-0.8-0.8-1.01.0-1.00.7-1.01.0-0.5-0.6-1.1-1.1-0.51.1-1.1-0.51.01.1-0.3-0.0
Ambulatory time after self-admin1.21.94.8-0.7-1.0-1.61.6-1.80.4-1.71.8-0.3-0.1-1.4-1.8-0.21.2-1.60.32.12.20.4-1.3
Bone: tissue strength0.60.72.3-0.1-0.3-0.60.6-0.7-0.2-0.60.80.40.3-0.8-1.10.61.5-1.50.51.11.20.7-0.7
Total heroin consumption0.00.10.3-0.1-0.1-0.30.3-0.20.1-0.10.2-0.1-0.1-0.5-0.1-0.10.0-0.1-0.10.20.2-0.0-0.5
Bone: trabecular number0.51.03.3-1.1-1.1-0.70.7-0.71.0-0.80.7-0.8-1.0-1.2-1.0-0.71.8-1.4-1.10.50.6-1.01.0
Bone: trabecular spacing0.71.02.31.21.00.7-0.70.5-1.30.6-0.51.11.41.10.61.1-1.40.91.5-0.1-0.11.4-1.5
Bone: trabecular thickness0.40.51.9-0.8-0.6-0.20.2-0.10.9-0.10.0-0.9-1.1-0.3-0.0-1.00.5-0.0-1.2-0.5-0.4-1.41.3
Bone: trabecular tissue density0.81.32.6-1.4-1.1-1.21.2-1.01.6-1.20.9-1.4-1.5-1.0-0.6-1.60.9-0.6-1.60.80.5-1.30.7
Water consumed over 24 hours0.40.91.3-1.1-1.0-1.01.0-0.91.1-1.00.8-1.0-1.1-0.8-0.8-1.01.0-1.0-1.10.70.7-0.90.5
Number of responses in last shaping day1.01.34.4-1.3-1.1-0.40.4-0.31.4-0.10.2-1.5-1.6-0.7-0.2-1.40.9-0.4-1.8-0.6-0.4-1.92.1