Lipt2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	NAcc	gene expression	Lipt2	0.15	0.09	7.3e-12	0.1	0.1	0.11	0.11	3.1e-11	5.0e-12	4.0e-13	7.8e-13
2	Brain	gene expression	Lipt2	0.2	0.12	3.3e-12	0.13	0.12	0.12	0.12	4.2e-12	2.4e-11	1.3e-11	1.4e-11
3	BLA	gene expression	Lipt2	0.17	0.11	4.1e-06	0.1	0.11	0.11	0.11	9.4e-06	1.8e-06	2.2e-06	1.8e-06
4	Adipose	gene expression	Lipt2	0.14	0.09	7.4e-14	0.1	0.1	0.1	0.1	7.3e-11	3.5e-11	1.1e-10	3.3e-11
5	PL	gene expression	Lipt2	0.24	0.19	4.9e-13	0.11	0.12	0.13	0.12	6.3e-12	1.3e-13	2.7e-14	1.8e-13
6	Liver	gene expression	Lipt2	0.06	0.04	7.8e-05	0.02	0.02	0.02	0.01	3.3e-03	5.2e-03	5.9e-03	6.7e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6
Bone: apparent density	0.2	0.3	0.7	-0.2	-0.4	0.2	-0.5	0.6	0.8
Area under the delay curve	0.1	0.1	0.3	-0.1	-0.0	0.2	0.3	-0.2	-0.5
BMI with tail	0.1	0.2	0.6	-0.2	0.1	0.2	0.6	-0.8	-0.7
BMI without tail	1.2	2.6	7.1	0.5	1.4	-0.3	1.5	-1.9	-2.7
Body weight	0.9	3.6	9.3	0.3	1.3	-0.1	2.1	-2.4	-3.0
Weight adjusted by age	0.7	0.8	2.5	0.7	1.0	-0.5	0.5	-0.8	-1.6
Bone surface	0.5	1.0	1.7	1.3	1.2	-1.2	-0.7	0.5	-0.4
Bone volume	0.4	0.6	1.0	1.0	0.9	-1.0	-0.7	0.6	-0.2
Breakpoint value in progressive ratio session	0.2	0.2	0.6	-0.4	-0.6	0.3	-0.3	0.3	0.8
Number of licking bursts	4.3	5.1	7.9	-2.8	-2.3	2.8	2.3	-1.9	0.1
Context. condit. distance diff. score	2.3	2.8	3.8	2.0	1.5	-2.0	-1.9	1.8	0.3
Locomotion velocity, session 1	0.5	0.5	1.4	-0.4	-0.7	0.3	-0.6	0.9	1.2
Locomotion distance, session 1	0.9	1.1	1.8	1.1	0.8	-1.1	-1.3	1.3	0.5
Locomotion velocity, session 2	0.0	0.0	0.1	0.3	0.3	-0.2	-0.1	-0.0	-0.2
Locomotion distance, session 2	0.4	0.6	0.8	0.8	0.7	-0.9	-0.9	0.8	0.2
Locomotion velocity, session 3	1.0	1.2	2.4	1.0	0.6	-1.0	-1.4	1.5	0.8
Locomotion distance, session 3	1.8	2.0	3.6	1.3	0.8	-1.3	-1.8	1.9	0.9
Stereotopy head waving bouts, day 3	0.5	0.6	1.2	-0.6	-0.4	0.7	1.1	-1.1	-0.6
Stereotopy head waving duration, day 3	0.1	0.1	0.2	0.4	0.1	-0.3	-0.5	0.4	0.3
Locomotion velocity, session 7	0.2	0.2	0.4	-0.5	-0.6	0.5	-0.0	0.2	0.6
Locomotion distance, session 7	0.1	0.1	0.2	-0.4	-0.4	0.5	0.4	-0.4	0.0
Stereotopy head waving bouts, day 7	2.3	2.6	3.8	1.9	1.6	-1.9	-1.8	1.6	0.1
Stereotopy head waving duration, day 7	2.6	3.2	5.0	2.2	2.0	-2.2	-1.7	1.5	-0.3
Locomotion velocity, session 8	0.6	0.8	1.1	1.1	0.9	-1.1	-0.9	0.9	0.1
Locomotion distance, session 8	2.0	2.9	4.3	2.1	1.8	-2.1	-1.8	1.5	0.0
Degree of sensitization distance	2.3	2.3	5.3	-0.9	-0.2	1.0	2.0	-2.3	-1.7
Degree of sensitization stereotypy	5.0	5.5	8.1	2.8	2.4	-2.9	-2.5	2.2	0.0
Conditioned locomotion	0.1	0.1	0.3	-0.2	-0.4	0.2	-0.3	0.3	0.6
Cocaine response after cond. corrected	2.0	2.3	3.2	-1.7	-1.2	1.7	1.8	-1.8	-0.4
Cocaine response after cond. not corrected	0.5	0.6	0.9	-0.9	-0.7	0.8	0.8	-1.0	-0.1
Cocaine response before conditioning	2.1	2.5	4.0	1.7	1.2	-1.7	-2.0	1.9	0.7
Saline control response	1.5	2.0	3.7	1.8	1.9	-1.6	-0.4	0.0	-1.4
Bone: connectivity density	0.3	0.5	1.1	0.1	-0.2	-0.2	-0.9	1.0	1.0
Bone: cortical apparent density	1.8	2.4	3.4	-1.8	-1.3	1.8	1.7	-1.6	-0.3
Bone: cortical area	0.3	0.4	0.9	0.8	0.9	-0.6	0.1	-0.2	-0.9
Bone: cortical porosity	1.2	1.3	2.0	1.2	0.7	-1.2	-1.4	1.4	0.7
Bone: cortical porosity	1.1	1.2	2.0	1.1	0.6	-1.1	-1.3	1.4	0.7
Bone: cortical thickness	0.1	0.1	0.2	-0.4	-0.5	0.5	0.1	0.1	0.4
Bone: cortical thickness	0.2	0.3	0.5	0.5	0.3	-0.5	-0.7	0.7	0.4
Bone: cortical tissue density	1.8	2.3	3.4	-1.8	-1.4	1.8	1.7	-1.6	-0.2
Condit. Reinf. active minus inactive responses	0.3	0.3	0.9	0.4	0.6	-0.3	0.4	-0.6	-0.9
Condit. Reinf. active-inactive response ratio	0.6	0.7	1.6	0.7	1.0	-0.6	0.3	-0.6	-1.2
Condit. Reinf. active responses	0.1	0.1	0.2	0.0	0.2	0.0	0.4	-0.4	-0.5
Condit. Reinf. inactive responses	0.0	0.1	0.1	-0.2	-0.3	0.2	-0.1	0.2	0.3
Incentive salience index mean	0.3	0.3	0.7	0.5	0.7	-0.4	0.2	-0.3	-0.9
Condit. Reinf. lever presses	0.1	0.1	0.2	0.4	0.5	-0.3	-0.1	0.1	-0.3
Condit. Reinf. active minus inactive responses	5.5	6.9	13.0	3.4	3.6	-3.1	-1.1	0.6	-2.3
Condit. Reinf. active-inactive response ratio	1.4	1.4	2.5	1.6	1.6	-1.5	-0.7	0.5	-0.7
Condit. Reinf. active responses	7.0	9.8	18.7	4.0	4.3	-3.7	-1.1	0.5	-3.0
Condit. Reinf. inactive responses	4.1	5.0	9.5	2.8	3.1	-2.5	-0.5	0.1	-2.4
Condit. Reinf. lever presses	13.3	18.1	31.4	5.6	5.6	-5.3	-2.7	2.0	-2.7
Condit. Reinf. lever reinforcers received	7.9	11.1	20.9	4.3	4.6	-4.0	-1.4	0.8	-2.9
Conditioned reinforcement - actives	3.0	3.0	4.1	1.8	1.6	-2.0	-2.0	2.0	0.6
Conditioned reinforcement - inactives	0.3	0.3	0.7	-0.7	-0.2	0.4	0.8	-0.9	-0.1
Conditioned locomotion	3.1	3.7	6.1	1.5	1.5	-2.0	-2.5	2.4	1.2
Patch foraging indifference point 0 sec	3.4	5.4	9.6	3.1	2.8	-2.9	-1.9	1.3	-1.1
Patch foraging indifference point AUC	0.4	0.5	1.3	0.1	0.4	0.1	0.9	-0.9	-1.1
Delay disc. indifference point, 0s delay	0.6	0.7	1.3	1.1	1.1	-1.0	-0.4	0.4	-0.6
Delay disc. indifference point, 16s delay	0.1	0.1	0.1	-0.3	-0.2	0.2	-0.1	0.3	0.3
Delay disc. indifference point, 2s delay	0.7	0.8	1.9	0.9	1.1	-0.8	0.2	-0.4	-1.4
Delay disc. indifference point, 24s delay	0.6	0.6	1.2	-1.1	-1.0	1.0	0.4	-0.1	0.5
Delay disc. indifference point, 4s delay	0.8	0.9	2.0	0.9	1.3	-0.7	0.4	-0.4	-1.4
Delay disc. indifference point, 8s delay	0.1	0.1	0.2	0.3	0.1	-0.2	-0.0	0.1	-0.5
Indifference point function ln k	2.0	2.7	5.0	1.4	0.9	-1.5	-2.2	2.2	1.2
Indifference point function log k	2.0	2.7	5.0	1.4	0.9	-1.5	-2.2	2.2	1.2
Patch foraging total patch changes 0 sec	2.7	4.3	7.7	2.8	2.6	-2.6	-1.6	1.1	-1.0
Patch foraging total patch changes 12 sec	1.1	1.5	2.7	1.4	1.6	-1.1	0.1	-0.5	-1.7
Patch foraging total patch changes 18 sec	1.7	2.2	3.9	2.0	2.0	-1.8	-0.6	0.3	-1.3
Patch foraging total patch changes 24 sec	0.9	1.0	2.3	1.0	1.5	-1.0	0.3	-0.5	-1.3
Patch foraging total patch changes 6 sec	0.6	0.9	1.4	1.2	1.1	-1.1	-0.9	0.9	-0.1
Patch foraging time to switch 0 sec	2.7	4.2	7.5	-2.7	-2.6	2.5	1.4	-0.6	1.5
Patch foraging water rate 0 sec	2.6	4.1	7.1	2.7	2.4	-2.5	-1.8	1.2	-0.8
Patch foraging water rate 12 sec	1.7	2.6	4.2	2.1	1.6	-2.0	-1.8	1.3	0.1
Patch foraging water rate 18 sec	0.8	1.1	2.2	1.3	1.5	-1.3	-0.6	0.2	-0.7
Patch foraging water rate 24 sec	1.6	2.3	4.1	1.4	0.8	-1.4	-2.0	2.0	1.0
Patch foraging water rate 6 sec	1.0	1.5	2.1	1.3	1.0	-1.4	-1.4	1.4	0.5
Seeking ratio, delayed vs. immediate footshock	1.2	1.4	3.0	-1.4	-1.7	1.2	0.4	-0.5	1.3
Distance traveled before self-admin	0.7	0.8	1.7	-1.2	-0.9	1.3	0.8	-0.4	0.2
Distance traveled after self-admin	1.2	1.3	3.8	-0.9	-1.0	0.4	-0.8	1.2	2.0
Extensor digitorum longus weight	0.4	1.4	2.9	-0.5	0.1	0.6	1.6	-1.7	-1.5
Bone: elastic displacement	1.6	1.8	3.6	-1.7	-1.9	1.6	0.4	-0.1	1.4
Bone: elastic work	1.5	2.0	3.8	-1.6	-1.9	1.5	0.1	0.3	1.7
Bone: endosteal estimation	1.1	2.4	4.8	1.6	2.0	-1.4	0.3	-0.8	-2.2
Bone: endosteal perimeter	1.3	2.8	5.1	1.9	2.3	-1.8	-0.0	-0.4	-2.1
Epididymis fat weight	1.2	2.7	5.4	-0.9	-0.2	1.1	2.3	-2.3	-2.0
Delta time in closed arm before/after self-admin	3.0	2.9	6.3	-1.1	-0.4	1.5	2.5	-2.2	-1.6
Delta time in open arm before/after self-admin	2.5	2.4	4.4	1.9	1.9	-2.1	-1.2	0.6	-0.9
Diff in mean of infusions in LGA sessions	2.9	3.2	5.2	-2.3	-1.9	2.3	1.8	-1.3	0.5
Delay discount exponential model param	0.1	0.1	0.2	0.1	0.1	-0.2	-0.4	0.2	0.5
Extinction: sum of active levers before priming	0.1	0.1	0.3	-0.3	-0.2	0.3	0.4	-0.5	-0.2
Active lever presses in extinction session 6	3.8	3.7	7.3	1.8	1.0	-1.9	-2.7	2.5	1.1
Bone: final force	0.0	0.0	0.0	-0.1	-0.1	0.2	0.2	-0.1	0.0
Bone: final moment	0.0	0.0	0.0	0.1	0.2	-0.1	0.1	-0.0	-0.2
Food consumed during 24 hour testing period	3.4	4.1	6.2	2.5	2.0	-2.5	-2.1	1.9	-0.0
Glucose	0.1	0.1	0.3	0.1	0.0	-0.2	-0.4	0.5	0.4
Heart weight	1.0	1.5	2.4	1.4	1.4	-1.5	-1.0	1.1	-0.3
Delay discount hyperbolic model param	0.1	0.2	0.6	-0.1	-0.2	-0.0	-0.4	0.3	0.8
Intermittent access intake day 1-15 change	0.7	0.7	1.0	0.9	0.8	-0.9	-0.9	1.0	0.2
Intermittent access intake escalation	0.9	0.9	1.4	1.0	0.9	-1.0	-1.1	1.2	0.3
Intermittent access intake escalation 2	0.2	0.2	0.5	0.5	0.7	-0.4	-0.2	0.4	-0.3
Intermitt. access day 1 inactive lever presses	0.5	0.6	1.0	-0.8	-0.5	0.7	1.0	-1.0	-0.2
Intermitt. access day 15 inactive lever presses	0.2	0.2	0.5	0.1	0.1	-0.4	-0.4	0.6	0.7
Intermitt. access escalation Index	0.3	0.3	0.5	0.5	0.6	-0.6	-0.5	0.7	0.0
Intermittent access day 1 total infusions	0.7	0.9	1.7	1.2	1.3	-1.3	-0.4	0.1	-0.5
Intermittent access day 15 total infusions	1.3	1.5	2.5	1.4	1.4	-1.6	-1.2	1.1	0.1
Intermittent access terminal intake (last 3 days)	1.1	1.2	2.1	1.3	1.5	-1.5	-0.9	0.8	-0.1
Intermittent access total infusions	0.7	0.7	1.5	1.0	1.2	-1.2	-0.5	0.3	-0.2
Intermittent access day 1 locomotion	0.2	0.2	0.3	0.2	0.2	-0.4	-0.5	0.5	0.6
Intermittent access day 15 total locomotion	1.4	1.5	2.3	1.2	1.2	-1.4	-1.4	1.5	0.5
Intermittent access total locomotion	0.5	0.5	1.0	0.8	0.9	-1.0	-0.7	0.6	0.0
Intermittent access standard deviation	0.1	0.1	0.3	0.3	0.5	-0.2	0.2	0.2	-0.5
Left kidney weight	1.0	2.8	7.0	1.5	2.2	-1.2	0.8	-0.8	-2.6
Right kidney weight	0.6	1.7	4.5	1.0	1.7	-0.8	0.7	-0.7	-2.1
Cocaine induced anxiety	1.5	1.8	3.2	-1.8	-1.6	1.7	1.0	-0.7	0.6
Post-drug Anxiety	0.9	1.1	1.6	-1.3	-0.9	1.2	1.1	-1.1	-0.0
Baseline Anxiety	0.7	0.8	1.5	1.2	1.2	-1.0	-0.3	-0.2	-0.8
Tail length	2.7	8.2	21.8	1.9	3.2	-1.4	2.0	-2.8	-4.7
Length with tail	1.5	5.5	14.5	0.9	2.1	-0.5	2.3	-2.8	-3.8
Length without tail	0.2	0.4	0.6	-0.8	-0.7	0.7	0.6	-0.3	0.4
Times rat made contact with spout	0.6	0.7	1.4	-0.6	-0.1	0.7	1.2	-1.2	-1.0
Lifetime Intake	0.8	1.0	1.9	1.2	1.3	-1.4	-0.7	0.3	-0.2
Liver weight, left	1.4	2.2	4.5	-1.1	-0.4	1.1	2.0	-2.1	-1.5
Liver weight, right	2.9	4.9	9.6	-1.6	-0.7	1.8	3.0	-3.1	-2.1
Locomotor activity	0.8	1.2	1.8	1.3	1.1	-1.2	-1.1	1.3	-0.2
Locomotor testing distance	1.7	2.8	4.6	2.1	2.1	-2.0	-1.1	1.1	-1.2
Locomotor testing rearing	0.8	1.2	3.0	1.1	1.4	-0.8	0.3	-0.4	-1.7
Locomotion in novel chamber	1.8	2.2	5.8	1.0	0.7	-1.1	-2.0	2.4	0.9
Locomotion in novel chamber post-restriction	2.1	2.5	3.5	1.7	1.4	-1.8	-1.9	1.7	0.5
Fecal boli incidents, locomotor time 1	1.2	1.3	2.2	1.2	0.7	-1.1	-1.5	1.5	0.7
Change in fecal boli incidents, locomotor task	1.1	1.1	2.0	-1.4	-1.0	1.3	1.0	-0.8	0.4
Time >=10cm from walls, locomotor time 1	1.7	1.7	2.6	1.5	1.0	-1.6	-1.6	1.4	0.2
Bouts of movement, locomotor time 1	0.2	0.2	0.4	0.5	0.3	-0.6	-0.6	0.5	0.1
Total resting periods, locomotor time 1	0.3	0.4	0.8	0.2	-0.1	-0.4	-0.9	0.8	0.7
Rest time, locomotor task time 1	0.2	0.3	0.7	-0.2	-0.6	0.1	-0.5	0.4	0.8
Distance moved, locomotor task time 1	0.5	0.6	1.7	0.3	0.7	-0.1	0.8	-0.7	-1.3
Vertical activity count, locomotor time 1	0.4	0.5	1.1	0.6	0.8	-0.4	0.4	-0.5	-1.1
Time >=10cm from walls, locomotor time 2	1.1	1.1	2.2	1.5	1.3	-1.4	-0.6	0.5	-0.6
Bouts of movement, locomotor time 2	0.5	0.5	1.4	0.4	0.9	-0.2	0.6	-0.6	-1.2
Total resting periods, locomotor time 2	0.4	0.4	1.1	0.1	0.5	0.1	0.8	-0.7	-1.0
Rest time, locomotor task time 2	2.7	3.1	5.3	-2.1	-2.3	2.1	1.3	-1.1	1.0
Distance moved, locomotor task time 2	2.7	3.1	5.4	2.3	2.3	-2.1	-0.9	0.6	-1.5
Vertical activity count, locomotor time 2	1.2	1.3	2.3	1.4	1.5	-1.2	0.0	-0.2	-1.5
Light reinforcement 1	1.8	3.4	5.5	-2.1	-2.4	2.3	1.6	-1.4	0.1
Light reinforcement 2	0.2	0.3	0.9	-0.4	-1.0	0.5	-0.3	0.2	0.7
Bone: marrow area	1.0	2.1	4.6	1.4	1.8	-1.2	0.4	-0.9	-2.1
Bone: maximum diameter	1.3	2.4	4.7	2.0	2.2	-1.8	-0.4	-0.0	-1.6
Bone: maximum force	0.0	0.0	0.0	0.2	0.2	-0.1	-0.0	0.0	-0.1
Bone: maximum moment	0.1	0.1	0.2	0.5	0.5	-0.4	-0.1	0.1	-0.3
Mean time between licks in bursts	4.2	5.9	10.8	2.7	3.3	-2.4	0.2	-1.0	-3.3
Mean num. licks in bursts	3.5	4.2	6.8	2.6	2.3	-2.5	-2.0	1.6	-0.4
Cd content in liver	0.8	0.9	1.8	-0.8	-0.5	0.9	1.3	-1.3	-0.7
Co content in liver	1.2	1.4	2.5	1.3	1.6	-1.2	-0.0	-0.3	-1.5
Cu content in liver	0.9	1.1	2.5	0.9	1.3	-0.8	0.4	-0.7	-1.6
Fe content in liver	0.1	0.1	0.1	-0.2	-0.1	0.2	0.3	-0.4	-0.3
K content in liver	0.4	0.4	0.7	-0.5	-0.3	0.5	0.8	-0.9	-0.6
Mg content in liver	0.1	0.1	0.2	0.4	0.4	-0.4	-0.1	-0.1	-0.4
Mn content in liver	1.3	1.5	2.9	-1.4	-1.6	1.2	-0.1	0.5	1.7
Na content in liver	0.2	0.2	0.3	0.6	0.5	-0.6	-0.6	0.5	0.1
Rb content in liver	0.6	0.7	1.3	1.2	1.1	-1.1	-0.4	0.2	-0.7
Se content in liver	2.7	3.3	5.9	-2.4	-2.4	2.2	1.1	-0.7	1.2
Sr content in liver	0.3	0.2	0.5	0.1	-0.3	-0.1	-0.6	0.7	0.7
Zn content in liver	3.7	4.1	7.3	2.7	2.6	-2.6	-1.5	1.0	-1.1
Bone: minimum diameter	1.0	1.9	5.2	0.6	1.2	-0.4	1.3	-1.7	-2.3
Time in familiar zone, hab. session 1	0.1	0.1	0.3	-0.1	0.1	0.1	0.5	-0.5	-0.5
Time in novel zone, hab. session 1	0.2	0.2	0.3	-0.5	-0.5	0.6	0.4	-0.3	0.1
Total zone transitions, hab. session 1	0.4	0.5	1.2	0.1	-0.2	-0.2	-0.8	1.0	1.1
Total locomotion distance, hab. session 1	1.3	1.9	3.8	-1.0	-0.5	1.1	1.9	-2.0	-1.3
Locomotion velocity, hab. session 1	0.8	1.1	2.2	-0.7	-0.3	0.8	1.4	-1.5	-1.0
Time in familiar zone, hab. session 2	1.1	1.1	2.2	1.4	1.5	-1.3	-0.5	0.3	-0.8
Time in novel zone, hab. session 2	0.3	0.3	0.6	-0.6	-0.8	0.6	-0.0	0.2	0.7
Total zone transitions, hab. session 2	1.5	1.9	2.9	1.5	1.1	-1.5	-1.7	1.6	0.5
Total locomotion distance, hab. session 2	0.9	1.1	2.7	-0.1	0.5	0.1	1.2	-1.5	-1.6
Locomotion velocity, hab. session 2	1.1	1.5	3.3	-0.3	0.4	0.3	1.5	-1.8	-1.8
Novel to familiar place preference ratio	0.1	0.1	0.1	0.3	0.2	-0.3	-0.3	0.2	-0.0
Novelty place preference	0.1	0.1	0.1	0.3	0.2	-0.3	-0.3	0.2	-0.0
Time in novel zone, NPP test	0.2	0.2	0.3	0.6	0.4	-0.5	-0.5	0.4	-0.0
Total zone transitions, NPP test	0.4	0.5	1.1	0.5	0.3	-0.6	-1.0	1.0	0.6
Total locomotion distance, NPP test	0.9	1.2	2.5	-0.7	-0.2	0.8	1.5	-1.6	-1.2
Locomotion velocity, NPP test	1.2	1.7	3.1	-1.1	-0.5	1.1	1.7	-1.8	-1.1
Intraocular pressure	0.5	0.7	1.8	0.5	0.2	-0.6	-1.1	1.3	0.9
Delta distance traveled before/after self-admin	1.1	1.2	1.9	0.7	0.7	-1.3	-1.4	1.2	1.1
Delta ambulatory time before/after self-admin	1.4	1.5	2.7	0.7	0.5	-1.3	-1.6	1.5	1.3
Parametrial fat weight	1.4	2.8	5.6	-1.2	-1.1	1.5	2.1	-2.4	-1.4
Pavlov. Cond. lever latency	1.0	1.3	2.3	-1.5	-1.5	1.4	0.7	-0.6	0.8
Pavlov. Cond. magazine entry latency	2.3	3.0	5.3	2.3	2.3	-2.1	-1.0	0.6	-1.3
Pavlov. Cond. change in total contacts	1.1	1.2	2.1	1.5	1.5	-1.3	-0.6	0.3	-0.8
Pavlov. Cond. index score	2.4	3.0	5.4	2.3	2.3	-2.1	-0.9	0.6	-1.4
Pavlov. Cond. latency score	2.3	3.0	5.3	2.3	2.3	-2.1	-1.0	0.6	-1.3
Pavlov. Cond. lever contacts	1.1	1.2	2.3	1.5	1.5	-1.3	-0.4	0.2	-1.1
Pavlov. Cond. magazine entry number	2.7	3.4	6.1	-2.5	-2.3	2.3	1.3	-0.8	1.1
Pavlov. Cond. intertrial magazine entries	0.8	1.0	1.7	-1.3	-1.3	1.2	0.5	-0.4	0.9
Pavlov. Cond. lever-magazine prob. diff.	1.9	2.4	4.2	2.0	2.0	-1.9	-0.9	0.5	-1.2
Pavlov. Cond. response bias	1.0	1.2	2.2	1.4	1.5	-1.3	-0.4	0.2	-1.1
Pavlov. Cond. lever latency	14.0	18.8	33.0	-5.7	-5.5	5.4	3.0	-2.4	2.4
Pavlov. Cond. magazine entry latency	3.5	4.0	6.5	2.6	2.2	-2.5	-1.9	1.7	-0.3
Pavlov. Cond. change in total contacts	10.9	15.0	25.9	5.1	4.8	-4.8	-3.0	2.5	-1.7
Pavlov. Cond. index score	10.9	14.0	24.4	4.9	4.7	-4.7	-2.8	2.2	-1.8
Pavlov. Cond. latency score	9.8	12.2	21.2	4.6	4.4	-4.4	-2.6	2.2	-1.6
Pavlov. Cond. lever contacts	14.4	19.7	34.3	5.9	5.7	-5.5	-3.1	2.4	-2.4
Pavlov. Cond. magazine entry number	6.2	7.6	12.3	-3.5	-3.1	3.4	2.5	-2.3	0.5
Pavlov. Cond. intertrial magazine entries	0.8	1.1	2.5	-0.0	0.5	0.2	1.3	-1.5	-1.6
Pavlov. Cond. lever-magazine prob. diff.	10.2	13.0	22.6	4.8	4.6	-4.5	-2.5	2.0	-1.9
Pavlov. Cond. response bias	14.7	20.0	34.7	5.9	5.6	-5.6	-3.3	2.7	-2.2
Time in closed arm before self-admin	3.8	4.3	8.3	1.5	0.8	-1.8	-2.8	2.9	1.8
Time in closed arm after self-admin	1.1	1.1	2.7	-0.9	-1.0	0.8	-0.3	1.2	1.6
Time in open arm before self-admin	3.6	3.9	6.1	-2.3	-2.0	2.5	2.1	-1.9	-0.3
Time in open arm after self-admin	1.0	1.1	3.5	0.4	0.8	-0.3	0.8	-1.3	-1.9
Bone: periosteal estimation	0.9	1.9	3.5	1.5	1.9	-1.3	0.2	-0.6	-1.9
Bone: periosteal perimeter	1.1	1.8	3.2	1.6	1.8	-1.4	-0.1	-0.2	-1.6
Bone: post-yield work	0.1	0.2	0.3	0.5	0.5	-0.5	-0.3	0.2	-0.2
Progressive ratio test 1 active lever presses	0.2	0.2	0.4	-0.6	-0.4	0.3	0.4	-0.4	0.4
Progressive ratio test 1 breakpoint	0.2	0.2	0.3	-0.6	-0.2	0.3	0.5	-0.5	0.2
Progressive ratio test 1 inactive lever presses	0.2	0.3	0.5	0.5	0.5	-0.6	0.2	-0.7	-0.4
Progressive ratio test 2 active lever presses	0.7	0.8	1.5	1.1	1.2	-1.1	-0.4	0.4	-0.7
Progressive ratio test 2 breakpoint	0.7	0.8	1.6	1.1	1.3	-1.1	-0.3	0.3	-0.7
Progressive ratio test 2 inactive lever presses	0.6	0.7	1.5	1.0	0.9	-1.2	-0.8	0.7	0.2
Incentive Sensitization - Responses	1.8	1.9	3.7	1.7	1.9	-1.6	-0.7	0.7	-1.0
Incentive Sensitization - Breakpoint	1.7	1.8	3.3	1.7	1.8	-1.6	-0.8	0.9	-0.8
Sum of active levers in priming session hrs 5-6	0.1	0.1	0.2	0.0	-0.4	0.2	-0.4	0.4	0.2
Progressive ratio	0.2	0.2	0.6	0.3	-0.0	-0.2	-0.6	0.8	0.4
Food seeking constrained by brief footshock	1.0	1.2	2.4	1.3	1.5	-1.0	0.1	-0.2	-1.6
Seeking ratio, punishment vs. effort	1.0	1.2	3.0	0.7	1.3	-0.6	0.8	-1.0	-1.7
Retroperitoneal fat weight	5.3	17.3	32.9	-3.3	-1.7	3.6	5.7	-5.7	-3.5
Reaction time number correct	0.9	1.2	2.5	0.3	-0.4	-0.3	-1.6	1.6	1.5
Reaction time mean minus median	0.6	0.8	1.3	1.1	1.0	-1.0	-0.2	-0.1	-1.2
Reaction time mean minus median AUC	0.9	1.1	2.2	1.5	1.1	-1.3	-0.9	0.7	-0.6
Reaction time num false alarms	1.7	2.3	3.5	-1.8	-1.4	1.9	1.7	-1.4	-0.2
Reaction time num false alarms AUC	0.8	1.1	1.8	-1.3	-1.1	1.3	1.1	-0.8	0.0
Reaction time trials correct on left	0.9	1.2	2.5	0.3	-0.4	-0.3	-1.6	1.6	1.5
Reaction time trials on left	0.9	1.3	2.5	0.3	-0.4	-0.3	-1.6	1.6	1.5
Reaction time mean	0.8	1.2	1.8	-1.2	-0.8	1.1	1.3	-1.3	-0.6
Reaction time mean AUC	1.0	1.4	2.0	-1.4	-1.2	1.3	1.2	-1.3	-0.3
Median of all reaction times	1.3	1.8	2.8	-1.7	-1.3	1.5	1.4	-1.4	-0.2
Reaction time omissions	0.3	0.5	0.8	-0.6	-0.5	0.7	0.9	-0.8	-0.5
Reaction time false alarm rate	1.4	1.9	3.3	-1.5	-1.0	1.5	1.8	-1.5	-0.6
Reaction time premature initiation rate	1.8	2.4	6.3	1.2	1.8	-1.0	0.9	-1.2	-2.5
Reaction time premature initiations	0.9	1.2	2.2	1.4	1.5	-1.2	-0.2	-0.1	-1.3
Std. dev. reaction times	0.6	0.8	2.6	0.3	0.8	-0.2	0.9	-0.9	-1.6
Reaction time trials completed	0.9	1.3	2.5	0.3	-0.4	-0.3	-1.6	1.6	1.5
Reaction time trials AUC	0.7	1.0	2.1	0.3	-0.3	-0.3	-1.4	1.4	1.2
Run reversals in cocaine runway, females	4.4	4.3	10.0	-0.7	0.1	1.0	2.7	-3.2	-2.6
Run reversals in cocaine runway, males	0.1	0.1	0.2	-0.3	-0.4	0.2	0.1	-0.1	0.3
Latency to leave start box in cocaine runway	3.2	3.5	5.5	-1.9	-1.5	2.1	2.2	-2.3	-0.6
Latency to leave start box in cocaine runway, F	3.4	3.7	7.3	-1.7	-1.1	1.8	2.5	-2.7	-1.3
Latency to leave start box in cocaine runway, M	0.4	0.4	0.7	-0.7	-0.9	0.6	-0.1	0.2	0.8
Std. dev. time between licks in bursts	1.9	2.2	6.0	1.1	1.7	-0.8	0.9	-1.3	-2.4
Total sessions with >9 infusions	1.9	2.1	3.8	1.8	1.6	-2.0	-1.5	0.8	0.1
Short access day 1 total inactive lever presses	0.2	0.2	0.4	-0.6	-0.6	0.3	0.4	-0.6	0.4
Short access day 10 total inactive lever presses	0.1	0.1	0.3	-0.4	-0.3	0.3	-0.1	0.5	0.5
Short access day 1 total infusions	1.8	1.9	3.5	1.8	1.9	-1.8	-0.9	0.4	-0.8
Short access day 10 total infusions	0.9	1.1	2.7	1.1	1.7	-1.3	-0.2	0.1	-0.8
Short access total infusions	0.7	0.8	1.4	1.1	1.2	-1.2	-0.2	-0.4	-0.7
Short access day 1 locomotion	1.8	1.9	3.4	1.5	0.9	-1.6	-1.8	1.4	0.7
Short access day 10 total locomotion	0.4	0.4	0.9	0.6	0.9	-0.6	-0.4	0.8	-0.2
Short access total locomotion	0.1	0.1	0.2	0.3	0.4	-0.5	-0.4	0.2	0.1
One hour access (0.3 mA shock)	1.6	1.9	3.5	1.6	1.9	-1.7	-1.0	1.1	-0.3
Compulsive drug intake	0.3	0.3	0.7	0.2	-0.4	-0.1	-0.8	0.7	0.7
One hour access (shock baseline)	1.1	1.3	3.0	1.3	1.7	-1.4	-0.6	0.7	-0.5
Social response proportion	0.5	0.5	1.0	-0.8	-0.4	0.7	1.0	-0.8	-0.3
Social responses	1.1	1.4	3.0	-0.8	-0.1	0.8	1.7	-1.7	-1.2
Social time	2.2	2.9	6.0	-2.1	-2.4	2.0	0.9	-0.8	1.3
Soleus weight	1.1	3.1	6.7	-0.4	0.4	0.6	2.3	-2.6	-2.5
Bone: stiffness	0.4	0.6	1.1	-0.7	-0.3	0.7	1.0	-1.0	-0.6
Tibialis anterior weight	0.2	0.6	1.6	0.4	0.7	-0.3	0.6	-0.8	-1.3
Time to tail flick, vehicle, before self-admin	0.1	0.1	0.4	-0.2	-0.2	0.1	-0.2	0.6	0.5
Time to tail flick, vehicle, after self-admin	1.9	2.0	3.4	1.7	1.2	-1.8	-1.6	1.2	0.1
Time to tail flick, test, before self-admin	0.5	0.4	0.9	0.5	0.8	-0.5	0.3	-0.7	-1.0
Time to tail flick, test, after self-admin	0.8	0.9	2.2	0.3	1.0	-0.3	0.9	-1.1	-1.5
Delta time to tail flick, vehicle, before/after SA	1.1	1.1	2.2	1.5	1.0	-1.5	-0.9	0.3	-0.3
Delta time to tail flick, test, before/after SA	0.3	0.2	0.4	-0.6	-0.5	0.6	0.6	-0.4	-0.0
Tibia length	1.9	5.2	7.5	2.6	1.9	-2.5	-2.7	2.6	0.8
Ambulatory time before self-admin	0.8	0.9	1.7	-1.3	-1.0	1.3	0.5	-0.0	0.7
Ambulatory time after self-admin	1.8	2.0	5.8	-0.8	-0.8	0.1	-1.2	1.9	2.4
Bone: tissue strength	1.1	1.0	2.8	-0.2	-0.7	0.1	-1.1	1.3	1.7
Total heroin consumption	0.3	0.3	0.8	0.7	0.3	-0.7	-0.9	0.4	0.2
Bone: trabecular number	0.7	1.2	2.2	-1.2	-1.4	1.0	-0.1	0.5	1.5
Bone: trabecular spacing	0.6	0.8	1.6	1.2	1.1	-1.2	-0.8	0.5	-0.3
Bone: trabecular thickness	0.2	0.2	0.3	-0.6	-0.4	0.6	0.5	-0.4	-0.1
Bone: trabecular tissue density	2.0	2.8	5.2	-1.4	-0.7	1.5	2.2	-2.3	-1.4
Water consumed over 24 hours	0.4	0.5	1.0	-0.9	-1.0	0.9	0.2	0.1	0.7
Number of responses in last shaping day	0.3	0.3	0.9	0.6	0.7	-0.4	0.3	-0.3	-0.9