Hub : Genes

Lipt2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 NAcc gene expression Lipt2 0.12 0.06 2.8e-16 0.1 0.11 0.12 0.11 1.3e-14 1.9e-16 4.9e-17 1.3e-16
2 BLA gene expression Lipt2 0.18 0.12 9.2e-06 0.08 0.1 0.09 0.09 4.4e-05 7.7e-06 1.3e-05 2.2e-05
3 IC gene expression Lipt2 0.21 0.11 1.4e-06 0.11 0.13 0.12 0.14 2.6e-05 4.3e-06 6.8e-06 1.3e-06
4 pVTA gene expression Lipt2 0.04 0.03 1.7e-03 0 0.02 0.01 0.01 1.4e-01 5.0e-03 3.3e-02 5.7e-02
5 Brain gene expression Lipt2 0.21 0.12 5.5e-13 0.15 0.14 0.14 0.15 1.1e-13 3.4e-13 2.4e-13 1.5e-13
6 Adipose gene expression Lipt2 0.12 0.07 2.9e-13 0.09 0.1 0.09 0.09 1.6e-10 1.1e-10 1.6e-10 1.8e-10
7 Liver gene expression Lipt2 0.06 0.04 1.7e-04 0.02 0.01 0.01 0.01 4.1e-03 1.5e-02 9.4e-03 9.6e-03
8 PL gene expression Lipt2 0.32 0.22 2.7e-13 0.11 0.13 0.13 0.13 2.2e-12 3.0e-14 2.0e-14 3.2e-14

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8
Bone: apparent density0.20.41.0-0.40.60.30.4-0.8-0.31.01.0
Area under the delay curve0.00.10.3-0.1-0.0-0.00.2-0.20.3-0.6-0.2
BMI with tail0.61.96.3-0.2-0.10.50.40.81.7-2.3-2.5
BMI without tail0.52.88.20.5-1.0-0.2-0.31.71.6-2.8-2.9
Body weight0.83.611.30.1-0.50.20.21.52.2-3.2-3.4
Weight adjusted by age0.10.41.30.4-0.4-0.5-0.20.20.4-1.2-0.9
Bone surface0.40.81.31.1-1.1-1.1-1.01.1-0.5-0.4-0.2
Bone volume0.20.30.60.7-0.7-0.8-0.70.7-0.4-0.20.0
Breakpoint value in progressive ratio session0.50.91.6-1.01.00.80.8-1.3-0.11.10.9
Number of licking bursts1.75.38.0-2.82.72.82.8-2.32.3-0.1-0.7
Context. condit. distance diff. score2.22.74.12.0-1.8-1.9-2.01.5-1.80.20.7
Locomotion velocity, session 10.50.61.7-0.30.50.30.2-0.8-0.61.31.2
Locomotion distance, session 10.91.11.81.2-1.1-1.2-1.20.8-1.30.50.9
Locomotion velocity, session 20.10.10.10.3-0.3-0.3-0.30.4-0.0-0.3-0.2
Locomotion distance, session 20.50.61.01.0-0.9-1.0-1.00.7-0.90.20.4
Locomotion velocity, session 30.91.01.91.1-0.9-1.1-1.10.5-1.40.81.1
Locomotion distance, session 31.51.73.21.3-1.1-1.3-1.40.7-1.81.01.4
Stereotopy head waving bouts, day 30.50.61.2-0.80.70.80.9-0.41.1-0.6-0.9
Stereotopy head waving duration, day 30.10.10.20.4-0.4-0.4-0.40.3-0.50.20.2
Locomotion velocity, session 70.20.30.6-0.50.50.40.4-0.7-0.10.80.5
Locomotion distance, session 70.10.20.2-0.50.50.40.5-0.50.30.2-0.1
Stereotopy head waving bouts, day 72.52.94.42.1-2.0-2.0-2.11.7-1.80.10.7
Stereotopy head waving duration, day 72.83.45.22.3-2.2-2.2-2.32.0-1.7-0.30.3
Locomotion velocity, session 80.70.81.31.2-1.1-1.1-1.10.9-0.90.10.2
Locomotion distance, session 82.23.14.92.2-2.1-2.1-2.21.8-1.7-0.00.4
Degree of sensitization distance1.81.94.3-1.00.81.11.2-0.22.0-1.6-2.1
Degree of sensitization stereotypy5.25.88.83.0-2.8-2.9-3.02.4-2.4-0.00.8
Conditioned locomotion0.20.30.7-0.20.30.10.1-0.5-0.50.90.8
Cocaine response after cond. corrected1.42.13.1-1.71.61.71.8-1.21.7-0.6-1.0
Cocaine response after cond. not corrected0.40.50.7-0.80.80.80.9-0.60.8-0.3-0.5
Cocaine response before conditioning2.12.54.11.9-1.6-1.8-1.91.2-2.00.71.1
Saline control response1.41.93.01.6-1.6-1.6-1.41.7-0.5-1.2-0.8
Bone: connectivity density0.30.41.40.00.1-0.1-0.1-0.4-0.81.11.2
Bone: cortical apparent density1.52.33.6-1.91.81.81.9-1.61.50.1-0.3
Bone: cortical area0.20.30.60.4-0.4-0.4-0.20.60.4-0.8-0.8
Bone: cortical porosity0.80.91.81.0-0.7-1.0-1.00.4-1.40.91.0
Bone: cortical porosity0.91.01.91.1-0.8-1.1-1.10.5-1.40.91.0
Bone: cortical thickness0.30.50.8-0.70.80.60.7-0.90.30.70.4
Bone: cortical thickness0.10.20.30.5-0.4-0.6-0.50.3-0.50.30.3
Bone: cortical tissue density1.42.33.6-1.91.81.81.8-1.61.40.2-0.2
Condit. Reinf. active minus inactive responses0.30.30.70.3-0.4-0.3-0.20.60.4-0.9-0.9
Condit. Reinf. active-inactive response ratio0.60.71.30.6-0.7-0.6-0.51.00.4-1.1-1.1
Condit. Reinf. active responses0.10.10.2-0.0-0.10.00.10.20.4-0.4-0.5
Condit. Reinf. inactive responses0.00.10.2-0.20.20.20.1-0.3-0.10.30.4
Incentive salience index mean0.20.30.60.5-0.5-0.4-0.30.70.3-0.8-0.7
Condit. Reinf. lever presses0.10.20.40.6-0.6-0.6-0.50.6-0.1-0.3-0.2
Condit. Reinf. active minus inactive responses5.07.812.93.3-3.4-3.2-3.03.6-1.1-2.1-1.3
Condit. Reinf. active-inactive response ratio0.91.52.41.5-1.5-1.4-1.41.5-0.6-0.7-0.3
Condit. Reinf. active responses7.811.218.93.9-4.0-3.8-3.54.3-1.0-2.8-1.8
Condit. Reinf. inactive responses3.95.89.82.7-2.8-2.6-2.43.1-0.5-2.3-1.6
Condit. Reinf. lever presses13.920.131.25.5-5.5-5.3-5.15.6-2.5-2.5-1.3
Condit. Reinf. lever reinforcers received9.012.721.14.2-4.3-4.1-3.84.6-1.2-2.8-1.8
Conditioned reinforcement - actives0.52.03.21.6-1.6-1.6-1.81.3-1.70.50.7
Conditioned reinforcement - inactives0.10.31.0-0.70.50.70.4-1.00.10.50.1
Conditioned locomotion2.43.56.71.9-1.8-1.8-2.21.2-2.61.51.7
Patch foraging indifference point 0 sec1.95.48.32.9-2.8-2.9-2.72.7-1.7-1.0-0.2
Patch foraging indifference point AUC0.20.61.90.2-0.2-0.10.10.50.9-1.2-1.4
Delay disc. indifference point, 0s delay1.01.11.71.3-1.3-1.3-1.21.3-0.5-0.9-0.4
Delay disc. indifference point, 16s delay0.00.10.2-0.30.20.20.2-0.3-0.00.20.4
Delay disc. indifference point, 2s delay0.91.02.10.9-1.0-0.8-0.71.40.3-1.4-1.0
Delay disc. indifference point, 24s delay0.60.91.5-1.21.21.01.1-1.20.60.50.5
Delay disc. indifference point, 4s delay1.11.22.80.9-1.1-1.0-0.71.20.5-1.7-1.3
Delay disc. indifference point, 8s delay0.00.10.20.1-0.1-0.2-0.0-0.40.1-0.5-0.1
Indifference point function ln k0.82.54.81.5-1.3-1.6-1.70.8-2.21.31.8
Indifference point function log k0.82.54.81.5-1.3-1.6-1.70.8-2.21.31.8
Patch foraging total patch changes 0 sec1.54.56.82.6-2.6-2.6-2.42.5-1.4-1.1-0.3
Patch foraging total patch changes 12 sec1.21.63.11.2-1.2-1.2-0.91.60.4-1.8-1.4
Patch foraging total patch changes 18 sec1.33.04.92.0-2.0-1.9-1.82.2-0.5-1.5-1.2
Patch foraging total patch changes 24 sec0.31.12.00.9-1.1-0.8-0.81.40.4-1.3-1.3
Patch foraging total patch changes 6 sec0.50.91.61.2-1.1-1.3-1.11.1-0.7-0.30.2
Patch foraging time to switch 0 sec1.24.87.1-2.62.72.62.4-2.71.21.50.8
Patch foraging water rate 0 sec1.24.46.72.6-2.6-2.6-2.52.4-1.6-0.8-0.1
Patch foraging water rate 12 sec0.72.74.22.0-1.9-1.9-2.01.6-1.80.20.6
Patch foraging water rate 18 sec0.51.21.91.3-1.3-1.2-1.31.4-0.6-0.5-0.3
Patch foraging water rate 24 sec1.52.13.71.5-1.2-1.5-1.50.8-1.91.11.7
Patch foraging water rate 6 sec0.91.31.91.3-1.2-1.3-1.40.9-1.40.50.7
Seeking ratio, delayed vs. immediate footshock0.91.32.5-1.31.51.61.2-1.10.21.20.3
Distance traveled before self-admin0.30.71.4-1.11.10.91.2-0.60.90.1-0.1
Distance traveled after self-admin0.81.44.4-0.70.80.60.4-0.7-0.92.11.9
Extensor digitorum longus weight0.41.43.4-0.70.50.80.90.11.8-1.7-1.8
Bone: elastic displacement1.72.23.9-1.61.81.51.5-2.00.31.41.1
Bone: elastic work1.82.44.2-1.61.81.51.5-2.10.11.71.3
Bone: endosteal estimation1.23.05.81.5-1.7-1.4-1.32.20.5-2.4-2.0
Bone: endosteal perimeter1.43.56.01.8-2.0-1.7-1.62.40.2-2.4-1.9
Epididymis fat weight0.21.11.6-1.11.01.21.2-0.71.2-0.6-1.0
Delta time in closed arm before/after self-admin2.72.54.9-1.61.31.71.7-0.52.2-1.2-1.9
Delta time in open arm before/after self-admin1.92.23.31.8-1.8-1.6-1.71.8-0.8-1.1-0.8
Diff in mean of infusions in LGA sessions3.05.38.5-2.92.92.92.7-2.51.61.20.2
Delay discount exponential model param0.10.10.40.1-0.00.0-0.20.1-0.40.60.2
Extinction: sum of active levers before priming0.10.10.40.1-0.10.0-0.00.20.2-0.6-0.6
Active lever presses in extinction session 63.53.57.71.6-1.4-1.9-1.80.5-2.81.62.4
Bone: final force0.10.10.2-0.40.40.30.4-0.40.20.10.0
Bone: final moment0.00.00.0-0.10.20.10.2-0.10.1-0.0-0.1
Food consumed during 24 hour testing period2.04.16.32.5-2.4-2.5-2.52.0-2.10.10.7
Glucose0.00.00.0-0.20.10.10.2-0.10.20.00.1
Heart weight0.71.11.81.2-1.3-1.2-1.31.2-0.9-0.20.2
Delay discount hyperbolic model param0.10.20.7-0.00.10.1-0.1-0.1-0.50.90.5
Intermittent access intake day 1-15 change0.10.81.41.0-0.8-1.2-1.00.8-1.00.40.8
Intermittent access intake escalation0.21.11.71.1-1.0-1.3-1.10.9-1.20.50.8
Intermittent access intake escalation 20.50.81.51.0-1.0-1.2-1.01.0-0.70.10.5
Intermitt. access day 1 inactive lever presses0.11.83.2-1.71.51.81.5-1.61.20.3-0.2
Intermitt. access day 15 inactive lever presses0.21.12.6-1.11.01.00.7-1.6-0.21.31.1
Intermitt. access escalation Index0.00.00.10.0-0.2-0.2-0.20.1-0.10.10.3
Intermittent access day 1 total infusions0.51.42.51.4-1.4-1.2-1.61.1-1.30.20.0
Intermittent access day 15 total infusions0.81.93.11.6-1.6-1.5-1.81.1-1.60.60.8
Intermittent access terminal intake (last 3 days)1.32.33.81.8-1.8-1.9-2.01.3-1.60.20.6
Intermittent access total infusions1.41.62.91.5-1.6-1.4-1.71.3-1.2-0.1-0.1
Intermittent access day 1 locomotion0.20.40.90.5-0.5-0.3-0.7-0.0-0.90.80.7
Intermittent access day 15 total locomotion0.41.53.01.2-1.1-1.3-1.40.4-1.71.01.1
Intermittent access total locomotion0.70.81.41.1-1.0-0.9-1.20.6-1.20.50.3
Intermittent access standard deviation0.10.30.90.4-0.5-0.5-0.20.60.4-1.0-0.5
Left kidney weight0.21.75.50.4-0.7-0.4-0.11.21.3-2.3-2.0
Right kidney weight0.42.67.50.5-0.8-0.4-0.21.51.6-2.7-2.7
Cocaine induced anxiety0.61.72.9-1.71.61.51.5-1.70.80.60.5
Post-drug Anxiety1.92.23.6-1.91.81.81.8-1.71.10.50.0
Baseline Anxiety0.10.20.60.4-0.4-0.3-0.40.50.1-0.5-0.7
Tail length0.73.810.60.8-1.1-0.6-0.42.01.9-3.3-3.2
Length with tail0.62.78.00.6-0.9-0.4-0.31.61.6-2.7-2.8
Length without tail0.10.30.4-0.50.50.60.6-0.40.6-0.3-0.6
Times rat made contact with spout0.50.61.4-0.70.50.70.8-0.21.2-0.8-1.0
Lifetime Intake1.62.03.51.7-1.8-1.5-1.91.5-1.3-0.1-0.2
Liver weight, left0.61.02.9-0.40.20.50.50.31.4-1.4-1.7
Liver weight, right1.52.76.0-1.41.11.41.5-0.42.4-1.8-2.1
Locomotor activity0.61.01.81.2-1.1-1.3-1.10.9-0.9-0.20.7
Locomotor testing distance0.92.33.71.8-1.9-1.8-1.61.9-0.6-1.2-0.3
Locomotor testing rearing0.31.12.90.8-1.0-0.9-0.61.30.5-1.7-1.2
Locomotion in novel chamber1.11.53.61.0-0.9-1.3-1.10.5-1.51.01.9
Locomotion in novel chamber post-restriction0.82.43.61.8-1.7-1.7-1.91.6-1.70.40.8
Fecal boli incidents, locomotor time 10.41.12.11.1-0.8-1.1-1.10.4-1.40.91.2
Change in fecal boli incidents, locomotor task0.60.71.2-1.11.01.11.0-0.20.90.3-0.2
Time >=10cm from walls, locomotor time 11.51.93.11.6-1.6-1.7-1.80.8-1.60.30.6
Bouts of movement, locomotor time 10.20.20.40.5-0.5-0.6-0.60.5-0.50.00.2
Total resting periods, locomotor time 10.30.30.70.4-0.3-0.4-0.50.3-0.90.70.7
Rest time, locomotor task time 10.20.31.2-0.10.20.1-0.0-0.2-0.71.10.9
Distance moved, locomotor task time 10.20.51.90.0-0.2-0.20.1-0.20.9-1.4-1.2
Vertical activity count, locomotor time 10.10.41.20.4-0.6-0.4-0.30.40.5-1.1-1.1
Time >=10cm from walls, locomotor time 20.51.32.11.4-1.5-1.4-1.41.0-0.6-0.7-0.6
Bouts of movement, locomotor time 20.20.61.30.6-0.5-0.5-0.31.20.6-1.1-1.1
Total resting periods, locomotor time 20.10.41.00.2-0.2-0.10.00.90.8-0.9-1.0
Rest time, locomotor task time 21.62.64.4-2.02.12.02.0-1.61.00.90.1
Distance moved, locomotor task time 22.02.64.52.0-2.1-2.1-1.91.2-0.7-1.4-0.7
Vertical activity count, locomotor time 20.51.21.71.2-1.3-1.2-1.11.0-0.1-1.2-1.0
Light reinforcement 10.73.15.0-2.12.22.12.2-2.01.5-0.0-0.2
Light reinforcement 20.10.30.6-0.40.60.40.4-0.8-0.20.60.7
Bone: marrow area1.12.65.61.3-1.6-1.2-1.12.00.6-2.4-2.0
Bone: maximum diameter1.32.54.41.7-1.8-1.6-1.42.1-0.0-1.8-1.4
Bone: maximum force0.00.00.0-0.20.20.10.2-0.20.1-0.0-0.0
Bone: maximum moment0.00.00.00.1-0.0-0.1-0.00.00.0-0.1-0.1
Mean time between licks in bursts0.95.49.42.2-2.4-2.0-1.83.00.4-3.1-2.6
Mean num. licks in bursts1.64.36.72.6-2.5-2.5-2.52.2-2.0-0.20.4
Cd content in liver0.60.61.3-0.70.60.80.8-0.31.1-0.8-0.9
Co content in liver1.21.42.31.2-1.3-1.1-1.01.50.1-1.4-1.1
Cu content in liver1.11.34.10.4-0.6-0.3-0.21.11.1-2.0-1.9
Fe content in liver0.00.00.1-0.20.20.20.2-0.20.1-0.0-0.0
K content in liver0.30.30.7-0.40.30.40.5-0.10.8-0.6-0.7
Mg content in liver0.10.10.10.3-0.3-0.3-0.30.4-0.1-0.3-0.1
Mn content in liver1.21.32.7-1.01.10.90.8-1.4-0.41.61.4
Na content in liver0.40.40.70.8-0.8-0.8-0.80.8-0.6-0.2-0.0
Rb content in liver0.30.30.50.7-0.7-0.7-0.60.7-0.3-0.3-0.1
Se content in liver4.04.77.7-2.62.62.52.4-2.80.91.71.1
Sr content in liver0.30.20.50.4-0.3-0.4-0.40.1-0.70.60.6
Zn content in liver2.42.84.81.9-2.0-1.8-1.72.2-0.4-1.6-1.1
Bone: minimum diameter1.01.95.60.4-0.7-0.3-0.11.31.4-2.4-2.3
Time in familiar zone, hab. session 10.10.10.5-0.20.10.20.20.10.5-0.5-0.7
Time in novel zone, hab. session 10.20.20.3-0.50.50.50.5-0.50.40.00.0
Total zone transitions, hab. session 10.30.41.20.2-0.0-0.2-0.3-0.3-0.81.11.0
Total locomotion distance, hab. session 11.21.73.6-1.10.91.11.3-0.41.9-1.3-1.7
Locomotion velocity, hab. session 10.70.92.1-0.80.60.80.9-0.21.4-1.1-1.3
Time in familiar zone, hab. session 21.21.42.41.4-1.4-1.3-1.31.5-0.5-0.8-0.7
Time in novel zone, hab. session 20.40.40.7-0.60.70.60.6-0.8-0.00.60.7
Total zone transitions, hab. session 21.41.82.81.6-1.4-1.5-1.61.0-1.70.61.0
Total locomotion distance, hab. session 20.70.92.8-0.1-0.10.20.30.51.3-1.6-1.7
Locomotion velocity, hab. session 20.91.23.5-0.30.10.40.50.51.5-1.8-1.9
Novel to familiar place preference ratio0.00.10.10.2-0.3-0.3-0.30.2-0.3-0.10.1
Novelty place preference0.00.10.10.3-0.3-0.3-0.30.2-0.3-0.10.1
Time in novel zone, NPP test0.10.20.30.5-0.5-0.5-0.50.4-0.4-0.10.2
Total zone transitions, NPP test0.30.50.90.6-0.4-0.6-0.60.2-1.00.71.0
Total locomotion distance, NPP test0.71.02.3-0.80.60.90.9-0.21.5-1.2-1.4
Locomotion velocity, NPP test1.01.42.9-1.11.01.21.3-0.51.7-1.1-1.3
Intraocular pressure0.30.51.40.5-0.3-0.6-0.60.0-1.00.91.2
Delta distance traveled before/after self-admin1.71.93.71.3-1.2-1.2-1.60.9-1.91.31.4
Delta ambulatory time before/after self-admin1.12.03.91.3-1.2-1.2-1.60.8-2.01.41.5
Parametrial fat weight0.61.42.0-1.41.31.41.4-1.01.3-0.5-1.0
Pavlov. Cond. lever latency1.31.62.6-1.61.61.51.5-1.60.70.70.3
Pavlov. Cond. magazine entry latency3.03.85.92.4-2.4-2.3-2.22.4-1.0-1.2-0.7
Pavlov. Cond. change in total contacts1.31.42.21.4-1.4-1.4-1.31.5-0.6-0.7-0.4
Pavlov. Cond. index score2.63.35.22.2-2.2-2.1-2.02.3-0.9-1.1-0.7
Pavlov. Cond. latency score2.53.14.92.2-2.2-2.1-2.02.2-0.9-1.0-0.6
Pavlov. Cond. lever contacts1.21.42.41.5-1.5-1.4-1.31.5-0.5-0.8-0.5
Pavlov. Cond. magazine entry number3.03.95.9-2.42.42.32.2-2.41.11.20.7
Pavlov. Cond. intertrial magazine entries0.91.01.7-1.21.21.11.1-1.30.40.80.5
Pavlov. Cond. lever-magazine prob. diff.2.12.64.12.0-2.0-1.9-1.82.0-0.8-0.9-0.6
Pavlov. Cond. response bias1.41.82.81.6-1.6-1.6-1.51.7-0.6-0.8-0.5
Pavlov. Cond. lever latency15.221.433.5-5.85.75.65.4-5.62.92.10.9
Pavlov. Cond. magazine entry latency3.24.57.22.7-2.5-2.6-2.62.3-1.9-0.20.3
Pavlov. Cond. change in total contacts6.616.125.35.0-4.9-4.9-4.74.8-2.7-1.6-0.6
Pavlov. Cond. index score9.915.624.55.0-4.8-4.8-4.74.7-2.6-1.6-0.6
Pavlov. Cond. latency score8.413.621.44.6-4.5-4.5-4.44.4-2.5-1.4-0.5
Pavlov. Cond. lever contacts13.820.331.85.6-5.5-5.4-5.35.5-2.8-2.1-0.9
Pavlov. Cond. magazine entry number6.28.012.7-3.63.43.53.4-3.12.40.5-0.3
Pavlov. Cond. intertrial magazine entries0.41.02.9-0.0-0.20.20.20.61.2-1.7-1.7
Pavlov. Cond. lever-magazine prob. diff.9.414.522.74.8-4.7-4.6-4.54.6-2.4-1.7-0.8
Pavlov. Cond. response bias15.120.932.85.7-5.6-5.5-5.45.5-3.0-1.9-0.7
Time in closed arm before self-admin1.62.85.31.6-1.5-1.7-1.80.8-2.31.32.0
Time in closed arm after self-admin0.91.02.3-1.01.00.90.7-0.9-0.21.51.3
Time in open arm before self-admin2.53.04.9-2.12.11.92.2-1.81.7-0.1-0.6
Time in open arm after self-admin0.70.82.70.3-0.3-0.2-0.00.60.8-1.6-1.7
Bone: periosteal estimation0.92.14.01.3-1.4-1.2-1.01.80.5-2.0-1.7
Bone: periosteal perimeter1.02.03.71.3-1.4-1.2-1.11.80.3-1.9-1.5
Bone: post-yield work0.00.10.20.2-0.3-0.2-0.20.30.0-0.4-0.3
Progressive ratio test 1 active lever presses0.10.21.0-0.10.10.3-0.1-0.3-0.51.00.6
Progressive ratio test 1 breakpoint0.10.20.9-0.20.20.4-0.1-0.3-0.51.00.6
Progressive ratio test 1 inactive lever presses0.10.20.5-0.30.30.60.1-0.7-0.30.70.1
Progressive ratio test 2 active lever presses0.20.30.70.6-0.8-0.7-0.80.5-0.4-0.2-0.2
Progressive ratio test 2 breakpoint0.30.30.70.7-0.8-0.7-0.80.5-0.4-0.2-0.2
Progressive ratio test 2 inactive lever presses0.10.30.70.5-0.6-0.5-0.8-0.3-0.80.40.2
Incentive Sensitization - Responses0.30.81.71.0-1.2-1.3-1.00.7-0.3-0.8-0.3
Incentive Sensitization - Breakpoint0.30.71.61.0-1.1-1.3-1.00.7-0.4-0.7-0.2
Sum of active levers in priming session hrs 5-60.10.10.60.1-0.0-0.3-0.1-0.8-0.40.10.3
Progressive ratio0.20.50.90.8-0.7-0.8-0.80.2-0.90.30.6
Food seeking constrained by brief footshock1.31.62.71.3-1.4-1.4-1.01.60.1-1.6-1.0
Seeking ratio, punishment vs. effort0.51.23.10.4-0.6-0.3-0.21.31.1-1.8-1.7
Retroperitoneal fat weight2.410.720.6-3.22.73.33.5-1.64.5-2.9-3.7
Reaction time number correct0.31.14.00.4-0.2-0.6-0.5-0.3-1.51.42.0
Reaction time mean minus median0.21.01.61.1-1.1-1.1-0.91.3-0.2-1.2-0.8
Reaction time mean minus median AUC0.21.32.11.4-1.4-1.4-1.31.3-0.9-0.5-0.1
Reaction time num false alarms1.42.33.6-1.91.71.81.9-1.41.7-0.4-0.5
Reaction time num false alarms AUC0.51.11.7-1.31.21.31.3-1.01.1-0.2-0.2
Reaction time trials correct on left0.31.14.00.4-0.2-0.6-0.5-0.3-1.51.42.0
Reaction time trials on left0.31.24.00.4-0.2-0.6-0.5-0.3-1.51.42.0
Reaction time mean0.51.11.6-1.21.01.21.2-0.81.3-0.7-0.8
Reaction time mean AUC0.61.42.2-1.41.31.51.4-1.11.2-0.2-0.6
Median of all reaction times1.21.93.0-1.71.51.71.6-1.31.4-0.3-0.6
Reaction time omissions0.20.40.9-0.30.30.30.5-0.00.8-0.9-0.9
Reaction time false alarm rate1.41.93.2-1.61.31.61.6-1.01.8-0.7-1.1
Reaction time premature initiation rate1.72.66.21.1-1.3-0.9-0.81.91.0-2.5-2.4
Reaction time premature initiations0.51.42.41.3-1.3-1.3-1.11.5-0.1-1.4-1.0
Std. dev. reaction times0.20.82.60.2-0.4-0.2-0.00.81.0-1.6-1.5
Reaction time trials completed0.31.24.00.4-0.2-0.6-0.5-0.3-1.51.42.0
Reaction time trials AUC0.30.93.20.4-0.2-0.6-0.5-0.2-1.31.11.8
Run reversals in cocaine runway, females2.42.66.7-0.90.61.11.20.02.3-2.3-2.6
Run reversals in cocaine runway, males0.10.10.3-0.40.30.40.2-0.6-0.00.30.1
Latency to leave start box in cocaine runway3.04.26.2-2.42.32.42.5-1.52.4-0.7-1.5
Latency to leave start box in cocaine runway, F3.84.88.2-2.32.12.42.5-1.32.9-1.4-2.2
Latency to leave start box in cocaine runway, M0.40.40.6-0.70.70.60.6-0.80.10.70.4
Std. dev. time between licks in bursts1.32.46.50.9-1.1-0.8-0.61.71.1-2.5-2.3
Total sessions with >9 infusions2.02.44.41.9-1.9-1.6-1.92.1-1.1-0.4-0.5
Short access day 1 total inactive lever presses0.00.10.2-0.10.00.4-0.10.20.00.1-0.5
Short access day 10 total inactive lever presses0.10.91.9-1.11.01.00.9-1.40.30.90.8
Short access day 1 total infusions1.93.86.92.3-2.4-2.0-2.22.6-0.9-1.3-1.0
Short access day 10 total infusions1.01.72.91.6-1.7-1.4-1.71.5-0.9-0.5-0.3
Short access total infusions1.72.44.01.9-2.0-1.6-2.01.7-1.3-0.5-0.5
Short access day 1 locomotion1.52.54.12.0-1.8-1.8-2.01.5-1.80.20.4
Short access day 10 total locomotion0.41.52.41.5-1.6-1.5-1.51.2-0.9-0.20.5
Short access total locomotion0.50.71.11.0-0.9-0.9-1.10.5-1.10.40.6
One hour access (0.3 mA shock)1.01.22.11.4-1.3-1.3-1.41.0-1.10.20.3
Compulsive drug intake0.81.23.0-0.60.80.40.5-1.3-0.91.61.7
One hour access (shock baseline)0.82.13.51.7-1.8-1.7-1.91.7-1.2-0.2-0.1
Social response proportion0.50.61.1-0.90.80.90.9-0.51.1-0.2-0.6
Social responses0.91.22.9-0.80.60.90.9-0.11.6-1.2-1.7
Social time1.82.94.7-2.02.12.01.9-2.20.71.30.5
Soleus weight1.02.96.9-0.80.50.91.10.32.5-2.5-2.6
Bone: stiffness0.50.81.2-1.11.01.11.1-0.71.1-0.3-0.6
Tibialis anterior weight0.20.61.80.1-0.2-0.00.10.60.9-1.3-1.3
Time to tail flick, vehicle, before self-admin0.20.20.40.5-0.5-0.6-0.5-0.1-0.60.30.6
Time to tail flick, vehicle, after self-admin0.81.63.31.5-1.4-1.3-1.51.8-1.0-0.3-0.4
Time to tail flick, test, before self-admin0.50.61.80.5-0.7-0.4-0.40.50.5-1.3-1.3
Time to tail flick, test, after self-admin0.50.51.60.2-0.4-0.2-0.10.50.8-1.3-1.2
Delta time to tail flick, vehicle, before/after SA0.70.72.00.9-0.8-0.7-0.81.4-0.5-0.5-0.8
Delta time to tail flick, test, before/after SA0.30.40.6-0.80.80.60.7-0.60.30.40.4
Tibia length1.74.76.82.6-2.3-2.5-2.61.7-2.60.81.5
Ambulatory time before self-admin0.30.81.4-1.21.21.01.1-0.80.50.80.6
Ambulatory time after self-admin1.21.96.6-0.10.30.1-0.3-0.2-1.72.62.3
Bone: tissue strength1.11.23.2-0.50.70.30.3-1.1-1.01.81.7
Total heroin consumption0.00.10.20.2-0.2-0.4-0.2-0.1-0.40.1-0.0
Bone: trabecular number0.91.72.8-1.41.41.21.2-1.70.11.51.2
Bone: trabecular spacing0.71.01.71.3-1.2-1.2-1.21.1-0.9-0.10.1
Bone: trabecular thickness0.40.60.9-0.90.90.80.9-0.80.8-0.0-0.2
Bone: trabecular tissue density1.52.64.6-1.81.51.71.9-1.02.2-1.0-1.4
Water consumed over 24 hours0.20.40.7-0.70.80.70.7-0.80.20.60.4
Number of responses in last shaping day0.50.71.5-0.70.50.80.7-0.31.2-1.0-1.0