Hub : Traits

Lifetime Intake

Tags: Behavior · Cocaine

Project: p50_paul_meyer_2020

3 significantly associated models · 2 unique genes

Significant Loci

# chr p0 p1 # assoc genes # joint models best TWAS P best SNP P cond SNP P % var exp joint genes
1 5 74868378 76264539 1 1 1.5e-07 0.017 0.047 31 RGD1566134
2 11 39057816 40174684 1 1 9.4e-10 0.013 1.000 100 Epha6

p0: physical position of the start of the locus. p1: physical position of the end of the locus. # joint models: number of models selected by step-wise conditional analysis.

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Body weight 1.5 1 0 0 0 1 RGD1566134
Heart weight 4.4 1 0 0 0 1 Epha6
Length without tail 2.7 1 0 0 0 1 RGD1566134
Parametrial fat weight 16.6 1 1 50 0 1 Epha6
Intraocular pressure 5.2 1 0 0 0 1 Epha6
Tibia length 2.4 1 0 0 0 1 Epha6
Food consumed during 24 hour testing period 5.5 2 0 0 0 1 Epha6 RGD1566134
Times rat made contact with spout 14.7 1 0 0 0 1 Epha6
Water consumed over 24 hours 13.4 2 0 0 0 1 Epha6 RGD1566134
Delay discounting total patch changes 12 sec 11.7 1 0 0 0 1 Epha6
Delay discounting total patch changes 18 sec 13.1 1 0 0 0 1 Epha6
Delay discounting total patch changes 24 sec 8.8 1 0 0 0 1 RGD1566134
Delay discounting total patch changes 6 sec 9.8 2 0 0 0 1 Epha6 RGD1566134
Delay discounting time to switch 0 sec 4.3 1 0 0 0 1 RGD1566134
Delay discounting water rate 18 sec 10.7 1 0 0 0 1 Epha6
Locomotor activity 6.9 1 0 0 0 1 Epha6
Locomotor testing distance 8.0 1 0 0 0 1 Epha6
Light reinforcement 1 3.3 1 0 0 0 1 RGD1566134
Reaction time premature initiation rate 8.8 1 0 0 0 1 Epha6
Reaction time premature initiations 5.0 1 0 0 0 1 Epha6
Conditioned locomotion 11.8 2 0 0 0 1 Epha6 RGD1566134
Cocaine response before conditioning 6.7 1 0 0 0 1 Epha6
Saline control response 17.3 1 0 0 0 1 RGD1566134
Condit. Reinf. lever presses 8.8 2 0 0 0 1 Epha6 RGD1566134
Pavlov. Cond. lever latency 13.2 2 1 50 0 1 Epha6 RGD1566134
Pavlov. Cond. magazine entry latency 14.1 1 0 0 0 1 RGD1566134
Pavlov. Cond. change in total contacts 16.2 1 0 0 0 1 RGD1566134
Pavlov. Cond. index score 22.4 1 1 50 0 1 RGD1566134
Pavlov. Cond. latency score 25.6 1 1 50 0 1 RGD1566134
Pavlov. Cond. lever contacts 10.1 2 1 50 0 1 Epha6 RGD1566134
Pavlov. Cond. magazine entry number 12.3 2 0 0 0 1 Epha6 RGD1566134
Pavlov. Cond. lever-magazine prob. diff. 19.7 1 0 0 0 1 RGD1566134
Pavlov. Cond. response bias 12.4 2 1 50 0 1 Epha6 RGD1566134
Conditioned reinforcement - actives 21.1 1 0 0 0 1 Epha6
Conditioned reinforcement - inactives 19.8 2 1 50 0 1 Epha6 RGD1566134
Intermittent access day 1 total infusions 18.4 2 1 50 0 1 Epha6 RGD1566134
Intermittent access day 15 total infusions 13.7 1 0 0 0 1 Epha6
Intermittent access terminal intake (last 3 days) 19.4 1 0 0 0 1 Epha6
Intermittent access total infusions 13.6 2 0 0 0 1 Epha6 RGD1566134
Intermittent access total locomotion 5.3 1 0 0 0 1 RGD1566134
Cocaine induced anxiety 15.4 1 0 0 0 1 Epha6
Post-drug Anxiety 5.9 1 0 0 0 1 Epha6
Baseline Anxiety 18.3 2 0 0 0 1 Epha6 RGD1566134
Incentive Sensitization - Responses 9.3 1 0 0 0 1 Epha6
Incentive Sensitization - Breakpoint 8.8 1 0 0 0 1 Epha6
Progressive ratio test 1 active lever presses 20.1 2 1 50 0 1 Epha6 RGD1566134
Progressive ratio test 1 breakpoint 23.3 2 1 50 0 1 Epha6 RGD1566134
Progressive ratio test 1 inactive lever presses 9.2 1 0 0 0 1 Epha6
Progressive ratio test 2 active lever presses 25.6 2 1 50 0 1 Epha6 RGD1566134
Progressive ratio test 2 breakpoint 21.0 2 1 50 0 1 Epha6 RGD1566134
Progressive ratio test 2 inactive lever presses 29.3 1 1 50 0 1 Epha6
Total sessions with >9 infusions 15.5 2 0 0 0 1 Epha6 RGD1566134
Short access day 1 total inactive lever presses 6.6 1 0 0 0 1 Epha6
Short access day 1 total infusions 32.0 2 1 50 0 1 Epha6 RGD1566134
Short access day 10 total infusions 18.6 1 0 0 0 1 RGD1566134
Short access total infusions 45.8 2 2 100 0 1 Epha6 RGD1566134
Short access day 1 locomotion 10.6 1 0 0 0 1 RGD1566134
Short access day 10 total locomotion 5.3 1 0 0 0 1 RGD1566134
Compulsive drug intake 11.5 1 0 0 0 1 RGD1566134
One hour access (0.3 mA shock) 24.1 2 1 50 0 1 Epha6 RGD1566134
One hour access (shock baseline) 19.6 1 0 0 0 1 Epha6
Context. condit. distance diff. score 6.7 1 0 0 0 1 RGD1566134
Locomotion distance, session 1 10.1 1 0 0 0 1 Epha6
Stereotopy head waving bouts, day 3 6.9 2 0 0 0 1 Epha6 RGD1566134
Stereotopy head waving duration, day 3 15.7 1 0 0 0 1 RGD1566134
Locomotion velocity, session 7 6.8 1 0 0 0 1 Epha6
Locomotion distance, session 7 12.3 1 0 0 0 1 Epha6
Stereotopy head waving bouts, day 7 26.4 1 1 50 0 1 RGD1566134
Stereotopy head waving duration, day 7 17.8 1 0 0 0 1 RGD1566134
Locomotion distance, session 8 5.0 1 0 0 0 1 Epha6
Degree of sensitization distance 6.1 1 0 0 0 1 Epha6
Degree of sensitization stereotypy 16.1 1 0 0 0 1 RGD1566134
Condit. Reinf. active minus inactive responses 10.4 2 0 0 0 1 Epha6 RGD1566134
Condit. Reinf. active-inactive response ratio 8.4 1 0 0 0 1 Epha6
Condit. Reinf. active responses 9.4 2 0 0 0 1 Epha6 RGD1566134
Condit. Reinf. inactive responses 8.3 1 0 0 0 1 RGD1566134
Incentive salience index mean 8.8 2 0 0 0 1 Epha6 RGD1566134
Condit. Reinf. lever presses 7.4 2 0 0 0 1 Epha6 RGD1566134
Time in familiar zone, hab. session 1 9.3 1 0 0 0 1 Epha6
Time in novel zone, hab. session 1 6.4 1 0 0 0 1 Epha6
Total zone transitions, hab. session 1 8.1 1 0 0 0 1 Epha6
Total locomotion distance, hab. session 1 4.8 1 0 0 0 1 Epha6
Locomotion velocity, hab. session 1 6.1 1 0 0 0 1 Epha6
Time in familiar zone, hab. session 2 29.9 1 1 50 0 1 Epha6
Time in novel zone, hab. session 2 25.2 1 1 50 0 1 Epha6
Total zone transitions, hab. session 2 6.1 1 0 0 0 1 Epha6
Total locomotion distance, hab. session 2 7.6 2 0 0 0 1 Epha6 RGD1566134
Locomotion velocity, hab. session 2 7.9 2 0 0 0 1 Epha6 RGD1566134
Novelty place preference 5.8 1 0 0 0 1 Epha6
Pavlov. Cond. lever latency 11.6 2 0 0 0 1 Epha6 RGD1566134
Pavlov. Cond. magazine entry latency 31.4 1 1 50 0 1 Epha6
Pavlov. Cond. change in total contacts 7.3 1 0 0 0 1 Epha6
Pavlov. Cond. index score 24.3 1 1 50 0 1 Epha6
Pavlov. Cond. latency score 22.4 1 1 50 0 1 Epha6
Pavlov. Cond. lever contacts 20.5 1 1 50 0 1 Epha6
Pavlov. Cond. magazine entry number 12.8 1 0 0 0 1 Epha6
Pavlov. Cond. intertrial magazine entries 6.5 1 0 0 0 1 RGD1566134
Pavlov. Cond. lever-magazine prob. diff. 22.9 1 1 50 0 1 Epha6
Pavlov. Cond. response bias 24.6 1 1 50 0 1 Epha6
Bone: apparent density 11.6 1 0 0 0 1 RGD1566134
Bone surface 7.7 2 0 0 0 1 Epha6 RGD1566134
Bone volume 11.6 1 0 0 0 1 RGD1566134
Bone: connectivity density 4.6 1 0 0 0 1 Epha6
Bone: cortical apparent density 5.4 1 0 0 0 1 RGD1566134
Bone: cortical porosity 5.6 1 0 0 0 1 Epha6
Bone: cortical thickness 13.4 1 0 0 0 1 Epha6
Bone: cortical tissue density 5.2 1 0 0 0 1 RGD1566134
Bone: endosteal estimation 3.8 2 0 0 0 1 Epha6 RGD1566134
Bone: endosteal perimeter 7.0 1 0 0 0 1 RGD1566134
Bone: marrow area 3.6 2 0 0 0 1 Epha6 RGD1566134
Bone: maximum diameter 6.4 2 0 0 0 1 Epha6 RGD1566134
Bone: periosteal estimation 3.0 1 0 0 0 1 Epha6
Bone: periosteal perimeter 4.9 1 0 0 0 1 Epha6
Bone: stiffness 7.0 1 0 0 0 1 Epha6
Bone: trabecular thickness 10.9 1 0 0 0 1 RGD1566134
Delta time in closed arm before/after self-admin 6.3 1 0 0 0 1 RGD1566134
Active lever presses in extinction session 6 7.4 1 0 0 0 1 RGD1566134
Time to tail flick, test, before self-admin 6.5 1 0 0 0 1 Epha6
Delta time to tail flick, vehicle, before/after SA 8.0 1 0 0 0 1 Epha6
Total heroin consumption 5.1 1 0 0 0 1 Epha6
Area under the delay curve 6.5 1 0 0 0 1 Epha6
Delay disc. indifference point, 0s delay 10.4 2 0 0 0 1 Epha6 RGD1566134
Delay disc. indifference point, 4s delay 14.3 2 0 0 0 1 Epha6 RGD1566134
Delay disc. indifference point, 8s delay 7.9 1 0 0 0 1 Epha6
Delay discount exponential model param 6.6 1 0 0 0 1 Epha6
Delay discount hyperbolic model param 6.7 1 0 0 0 1 Epha6
Time >=10cm from walls, locomotor time 1 6.0 1 0 0 0 1 Epha6
Bouts of movement, locomotor time 1 7.9 1 0 0 0 1 Epha6
Vertical activity count, locomotor time 1 7.2 1 0 0 0 1 Epha6
Time >=10cm from walls, locomotor time 2 14.7 1 0 0 0 1 RGD1566134
Total resting periods, locomotor time 2 5.4 1 0 0 0 1 RGD1566134
Rest time, locomotor task time 2 5.7 1 0 0 0 1 Epha6
Distance moved, locomotor task time 2 5.0 1 0 0 0 1 RGD1566134
Weight adjusted by age 7.9 1 0 0 0 1 RGD1566134
Seeking ratio, delayed vs. immediate footshock 15.3 2 1 50 0 1 Epha6 RGD1566134
Locomotion in novel chamber post-restriction 15.3 1 0 0 0 1 Epha6
Run reversals in cocaine runway, females 11.1 1 0 0 0 1 RGD1566134
Latency to leave start box in cocaine runway 8.5 1 0 0 0 1 Epha6
Fe content in liver 8.8 1 0 0 0 1 RGD1566134
Na content in liver 12.0 2 0 0 0 1 Epha6 RGD1566134
Rb content in liver 5.3 1 0 0 0 1 RGD1566134
Se content in liver 11.1 1 0 0 0 1 Epha6
Zn content in liver 15.0 1 0 0 0 1 RGD1566134

chisq ratio: Average Chi2 statistic for the selected genes in the secondary trait, divided by the average statistic for all genes in the secondary trait. # genes+: Shared significant genes at Bonferroni correction. # genes++: Shared significant genes at transcriptome-wide significance. % genes++: Number of [++] genes as a percentage of primary trait’s total joint genes. corr: Correlation of effect sizes across the [+] genes.

Associations by panel

tissue modality # hits % hits/tests avg chisq
Adipose alternative polyA 0 0.000 1.14
Adipose alternative TSS 0 0.000 1.22
Adipose gene expression 0 0.000 1.12
Adipose isoform ratio 0 0.000 1.18
Adipose intron excision ratio 0 0.000 1.10
Adipose mRNA stability 0 0.000 1.13
BLA alternative polyA 0 0.000 1.07
BLA alternative TSS 0 0.000 1.10
BLA gene expression 0 0.000 1.13
BLA isoform ratio 0 0.000 1.09
BLA intron excision ratio 0 0.000 1.09
BLA mRNA stability 0 0.000 1.15
Brain alternative polyA 0 0.000 1.07
Brain alternative TSS 0 0.000 1.07
Brain gene expression 0 0.000 1.12
Brain isoform ratio 0 0.000 1.15
Brain intron excision ratio 0 0.000 1.07
Brain mRNA stability 0 0.000 1.12
Eye alternative polyA 0 0.000 1.26
Eye alternative TSS 0 0.000 1.08
Eye gene expression 0 0.000 1.23
Eye isoform ratio 0 0.000 1.15
Eye intron excision ratio 0 0.000 0.99
Eye mRNA stability 0 0.000 1.18
IL alternative polyA 0 0.000 1.05
IL alternative TSS 0 0.000 1.22
IL gene expression 0 0.000 1.13
IL isoform ratio 0 0.000 1.09
IL intron excision ratio 0 0.000 1.10
IL mRNA stability 0 0.000 1.22
LHb alternative polyA 0 0.000 1.10
LHb alternative TSS 0 0.000 1.15
LHb gene expression 0 0.000 1.19
LHb isoform ratio 0 0.000 1.09
LHb intron excision ratio 0 0.000 1.09
LHb mRNA stability 0 0.000 1.17
Liver alternative polyA 0 0.000 1.01
Liver alternative TSS 0 0.000 1.13
Liver gene expression 0 0.000 1.12
Liver isoform ratio 0 0.000 1.16
Liver intron excision ratio 1 0.023 1.16
Liver mRNA stability 0 0.000 1.12
NAcc alternative polyA 0 0.000 1.03
NAcc alternative TSS 0 0.000 1.16
NAcc gene expression 0 0.000 1.13
NAcc isoform ratio 0 0.000 1.11
NAcc intron excision ratio 0 0.000 1.07
NAcc mRNA stability 0 0.000 1.14
OFC alternative polyA 0 0.000 1.11
OFC alternative TSS 0 0.000 0.95
OFC gene expression 0 0.000 1.16
OFC isoform ratio 0 0.000 1.12
OFC intron excision ratio 0 0.000 1.02
OFC mRNA stability 0 0.000 1.20
PL alternative polyA 0 0.000 1.05
PL alternative TSS 2 0.170 1.10
PL gene expression 0 0.000 1.13
PL isoform ratio 0 0.000 1.12
PL intron excision ratio 0 0.000 1.05
PL mRNA stability 0 0.000 1.17

avg chisq: Average Chi2 (squared Z-score) across all models in this panel for this trait.