Hub : Traits

Lifetime Intake

Tags: Behavior · Cocaine

Project: p50_paul_meyer_2020

2 loci · 2 genes with independent associations · 2 total associated genes

Significant Loci

#	Chr	Start pos	End pos	# assoc genes	# joint models	Best TWAS P	Best GWAS P	Cond GWAS P	Joint genes
1	5	74868378	76264539	1	1	1.51e-07	1.68e-02	4.73e-02	RGD1566134
2	11	39057816	40174684	1	1	9.42e-10	1.34e-02	1.00e+00	Epha6

Pleiotropic Associations

Trait	Chi2 ratio	# genes+	# genes++	% genes++	Corr	Corr P	Genes
Body weight	1.48	1	0	0	0	1e+00	RGD1566134
Heart weight	4.41	1	0	0	0	1e+00	Epha6
Length without tail	2.68	1	0	0	0	1e+00	RGD1566134
Parametrial fat weight	16.59	1	1	50	0	1e+00	Epha6
Intraocular pressure	5.23	1	0	0	0	1e+00	Epha6
Tibia length	2.39	1	0	0	0	1e+00	Epha6
Food consumed during 24 hour testing period	5.49	2	0	0	0	1e+00	Epha6 RGD1566134
Times rat made contact with spout	14.73	1	0	0	0	1e+00	Epha6
Water consumed over 24 hours	13.45	2	0	0	0	1e+00	Epha6 RGD1566134
Delay discounting total patch changes 12 sec	11.65	1	0	0	0	1e+00	Epha6
Delay discounting total patch changes 18 sec	13.14	1	0	0	0	1e+00	Epha6
Delay discounting total patch changes 24 sec	8.82	1	0	0	0	1e+00	RGD1566134
Delay discounting total patch changes 6 sec	9.79	2	0	0	0	1e+00	Epha6 RGD1566134
Delay discounting time to switch 0 sec	4.28	1	0	0	0	1e+00	RGD1566134
Delay discounting water rate 18 sec	10.67	1	0	0	0	1e+00	Epha6
Locomotor activity	6.88	1	0	0	0	1e+00	Epha6
Locomotor testing distance	7.95	1	0	0	0	1e+00	Epha6
Light reinforcement 1	3.33	1	0	0	0	1e+00	RGD1566134
Reaction time premature initiation rate	8.75	1	0	0	0	1e+00	Epha6
Reaction time premature initiations	4.96	1	0	0	0	1e+00	Epha6
Conditioned locomotion	11.84	2	0	0	0	1e+00	Epha6 RGD1566134
Cocaine response before conditioning	6.74	1	0	0	0	1e+00	Epha6
Saline control response	17.27	1	0	0	0	1e+00	RGD1566134
Condit. Reinf. lever presses	8.78	2	0	0	0	1e+00	Epha6 RGD1566134
Pavlov. Cond. lever latency	13.25	2	1	50	0	1e+00	Epha6 RGD1566134
Pavlov. Cond. magazine entry latency	14.11	1	0	0	0	1e+00	RGD1566134
Pavlov. Cond. change in total contacts	16.25	1	0	0	0	1e+00	RGD1566134
Pavlov. Cond. index score	22.35	1	1	50	0	1e+00	RGD1566134
Pavlov. Cond. latency score	25.6	1	1	50	0	1e+00	RGD1566134
Pavlov. Cond. lever contacts	10.11	2	1	50	0	1e+00	Epha6 RGD1566134
Pavlov. Cond. magazine entry number	12.3	2	0	0	0	1e+00	Epha6 RGD1566134
Pavlov. Cond. lever-magazine prob. diff.	19.7	1	0	0	0	1e+00	RGD1566134
Pavlov. Cond. response bias	12.41	2	1	50	0	1e+00	Epha6 RGD1566134
Conditioned reinforcement - actives	21.15	1	0	0	0	1e+00	Epha6
Conditioned reinforcement - inactives	19.77	2	1	50	0	1e+00	Epha6 RGD1566134
Intermittent access day 1 total infusions	18.44	2	1	50	0	1e+00	Epha6 RGD1566134
Intermittent access day 15 total infusions	13.65	1	0	0	0	1e+00	Epha6
Intermittent access terminal intake (last 3 days)	19.39	1	0	0	0	1e+00	Epha6
Intermittent access total infusions	13.57	2	0	0	0	1e+00	Epha6 RGD1566134
Intermittent access total locomotion	5.32	1	0	0	0	1e+00	RGD1566134
Cocaine induced anxiety	15.39	1	0	0	0	1e+00	Epha6
Post-drug Anxiety	5.89	1	0	0	0	1e+00	Epha6
Baseline Anxiety	18.29	2	0	0	0	1e+00	Epha6 RGD1566134
Incentive Sensitization - Responses	9.27	1	0	0	0	1e+00	Epha6
Incentive Sensitization - Breakpoint	8.83	1	0	0	0	1e+00	Epha6
Progressive ratio test 1 active lever presses	20.06	2	1	50	0	1e+00	Epha6 RGD1566134
Progressive ratio test 1 breakpoint	23.29	2	1	50	0	1e+00	Epha6 RGD1566134
Progressive ratio test 1 inactive lever presses	9.17	1	0	0	0	1e+00	Epha6
Progressive ratio test 2 active lever presses	25.61	2	1	50	0	1e+00	Epha6 RGD1566134
Progressive ratio test 2 breakpoint	21.02	2	1	50	0	1e+00	Epha6 RGD1566134
Progressive ratio test 2 inactive lever presses	29.3	1	1	50	0	1e+00	Epha6
Total sessions with >9 infusions	15.51	2	0	0	0	1e+00	Epha6 RGD1566134
Short access day 1 total inactive lever presses	6.58	1	0	0	0	1e+00	Epha6
Short access day 1 total infusions	31.99	2	1	50	0	1e+00	Epha6 RGD1566134
Short access day 10 total infusions	18.58	1	0	0	0	1e+00	RGD1566134
Short access total infusions	45.78	2	2	100	0	1e+00	Epha6 RGD1566134
Short access day 1 locomotion	10.55	1	0	0	0	1e+00	RGD1566134
Short access day 10 total locomotion	5.32	1	0	0	0	1e+00	RGD1566134
Compulsive drug intake	11.5	1	0	0	0	1e+00	RGD1566134
One hour access (0.3 mA shock)	24.07	2	1	50	0	1e+00	Epha6 RGD1566134
One hour access (shock baseline)	19.56	1	0	0	0	1e+00	Epha6
Context. condit. distance diff. score	6.72	1	0	0	0	1e+00	RGD1566134
Locomotion distance, session 1	10.11	1	0	0	0	1e+00	Epha6
Stereotopy head waving bouts, day 3	6.89	2	0	0	0	1e+00	Epha6 RGD1566134
Stereotopy head waving duration, day 3	15.72	1	0	0	0	1e+00	RGD1566134
Locomotion velocity, session 7	6.82	1	0	0	0	1e+00	Epha6
Locomotion distance, session 7	12.27	1	0	0	0	1e+00	Epha6
Stereotopy head waving bouts, day 7	26.39	1	1	50	0	1e+00	RGD1566134
Stereotopy head waving duration, day 7	17.8	1	0	0	0	1e+00	RGD1566134
Locomotion distance, session 8	5.02	1	0	0	0	1e+00	Epha6
Degree of sensitization distance	6.07	1	0	0	0	1e+00	Epha6
Degree of sensitization stereotypy	16.12	1	0	0	0	1e+00	RGD1566134
Condit. Reinf. active minus inactive responses	10.44	2	0	0	0	1e+00	Epha6 RGD1566134
Condit. Reinf. active-inactive response ratio	8.4	1	0	0	0	1e+00	Epha6
Condit. Reinf. active responses	9.38	2	0	0	0	1e+00	Epha6 RGD1566134
Condit. Reinf. inactive responses	8.3	1	0	0	0	1e+00	RGD1566134
Incentive salience index mean	8.79	2	0	0	0	1e+00	Epha6 RGD1566134
Condit. Reinf. lever presses	7.4	2	0	0	0	1e+00	Epha6 RGD1566134
Time in familiar zone, hab. session 1	9.26	1	0	0	0	1e+00	Epha6
Time in novel zone, hab. session 1	6.42	1	0	0	0	1e+00	Epha6
Total zone transitions, hab. session 1	8.13	1	0	0	0	1e+00	Epha6
Total locomotion distance, hab. session 1	4.8	1	0	0	0	1e+00	Epha6
Locomotion velocity, hab. session 1	6.08	1	0	0	0	1e+00	Epha6
Time in familiar zone, hab. session 2	29.91	1	1	50	0	1e+00	Epha6
Time in novel zone, hab. session 2	25.18	1	1	50	0	1e+00	Epha6
Total zone transitions, hab. session 2	6.11	1	0	0	0	1e+00	Epha6
Total locomotion distance, hab. session 2	7.61	2	0	0	0	1e+00	Epha6 RGD1566134
Locomotion velocity, hab. session 2	7.9	2	0	0	0	1e+00	Epha6 RGD1566134
Novelty place preference	5.77	1	0	0	0	1e+00	Epha6
Pavlov. Cond. lever latency	11.55	2	0	0	0	1e+00	Epha6 RGD1566134
Pavlov. Cond. magazine entry latency	31.42	1	1	50	0	1e+00	Epha6
Pavlov. Cond. change in total contacts	7.31	1	0	0	0	1e+00	Epha6
Pavlov. Cond. index score	24.26	1	1	50	0	1e+00	Epha6
Pavlov. Cond. latency score	22.39	1	1	50	0	1e+00	Epha6
Pavlov. Cond. lever contacts	20.49	1	1	50	0	1e+00	Epha6
Pavlov. Cond. magazine entry number	12.84	1	0	0	0	1e+00	Epha6
Pavlov. Cond. intertrial magazine entries	6.47	1	0	0	0	1e+00	RGD1566134
Pavlov. Cond. lever-magazine prob. diff.	22.92	1	1	50	0	1e+00	Epha6
Pavlov. Cond. response bias	24.61	1	1	50	0	1e+00	Epha6
Bone: apparent density	11.64	1	0	0	0	1e+00	RGD1566134
Bone surface	7.65	2	0	0	0	1e+00	Epha6 RGD1566134
Bone volume	11.62	1	0	0	0	1e+00	RGD1566134
Bone: connectivity density	4.61	1	0	0	0	1e+00	Epha6
Bone: cortical apparent density	5.36	1	0	0	0	1e+00	RGD1566134
Bone: cortical porosity	5.58	1	0	0	0	1e+00	Epha6
Bone: cortical thickness	13.39	1	0	0	0	1e+00	Epha6
Bone: cortical tissue density	5.24	1	0	0	0	1e+00	RGD1566134
Bone: endosteal estimation	3.83	2	0	0	0	1e+00	Epha6 RGD1566134
Bone: endosteal perimeter	6.97	1	0	0	0	1e+00	RGD1566134
Bone: marrow area	3.56	2	0	0	0	1e+00	Epha6 RGD1566134
Bone: maximum diameter	6.44	2	0	0	0	1e+00	Epha6 RGD1566134
Bone: periosteal estimation	2.98	1	0	0	0	1e+00	Epha6
Bone: periosteal perimeter	4.91	1	0	0	0	1e+00	Epha6
Bone: stiffness	6.97	1	0	0	0	1e+00	Epha6
Bone: trabecular thickness	10.89	1	0	0	0	1e+00	RGD1566134
Delta time in closed arm before/after self-admin	6.35	1	0	0	0	1e+00	RGD1566134
Active lever presses in extinction session 6	7.43	1	0	0	0	1e+00	RGD1566134
Time to tail flick, test, before self-admin	6.51	1	0	0	0	1e+00	Epha6
Delta time to tail flick, vehicle, before/after SA	8	1	0	0	0	1e+00	Epha6
Total heroin consumption	5.1	1	0	0	0	1e+00	Epha6
Area under the delay curve	6.54	1	0	0	0	1e+00	Epha6
Delay disc. indifference point, 0s delay	10.4	2	0	0	0	1e+00	Epha6 RGD1566134
Delay disc. indifference point, 4s delay	14.3	2	0	0	0	1e+00	Epha6 RGD1566134
Delay disc. indifference point, 8s delay	7.89	1	0	0	0	1e+00	Epha6
Delay discount exponential model param	6.64	1	0	0	0	1e+00	Epha6
Delay discount hyperbolic model param	6.66	1	0	0	0	1e+00	Epha6
Time >=10cm from walls, locomotor time 1	6.04	1	0	0	0	1e+00	Epha6
Bouts of movement, locomotor time 1	7.86	1	0	0	0	1e+00	Epha6
Vertical activity count, locomotor time 1	7.25	1	0	0	0	1e+00	Epha6
Time >=10cm from walls, locomotor time 2	14.74	1	0	0	0	1e+00	RGD1566134
Total resting periods, locomotor time 2	5.37	1	0	0	0	1e+00	RGD1566134
Rest time, locomotor task time 2	5.68	1	0	0	0	1e+00	Epha6
Distance moved, locomotor task time 2	4.98	1	0	0	0	1e+00	RGD1566134
Weight adjusted by age	7.91	1	0	0	0	1e+00	RGD1566134
Seeking ratio, delayed vs. immediate footshock	15.29	2	1	50	0	1e+00	Epha6 RGD1566134
Locomotion in novel chamber post-restriction	15.32	1	0	0	0	1e+00	Epha6
Run reversals in cocaine runway, females	11.07	1	0	0	0	1e+00	RGD1566134
Latency to leave start box in cocaine runway	8.54	1	0	0	0	1e+00	Epha6
Fe content in liver	8.75	1	0	0	0	1e+00	RGD1566134
Na content in liver	12.03	2	0	0	0	1e+00	Epha6 RGD1566134
Rb content in liver	5.26	1	0	0	0	1e+00	RGD1566134
Se content in liver	11.12	1	0	0	0	1e+00	Epha6
Zn content in liver	15.04	1	0	0	0	1e+00	RGD1566134

Associations by panel

Tissue	RNA modality	# hits	% hits/tests	Avg chisq
Adipose	alternative polyA	0	0	1.14
Adipose	alternative TSS	0	0	1.22
Adipose	gene expression	0	0	1.12
Adipose	isoform ratio	0	0	1.18
Adipose	intron excision ratio	0	0	1.1
Adipose	mRNA stability	0	0	1.13
BLA	alternative polyA	0	0	1.07
BLA	alternative TSS	0	0	1.1
BLA	gene expression	0	0	1.13
BLA	isoform ratio	0	0	1.09
BLA	intron excision ratio	0	0	1.09
BLA	mRNA stability	0	0	1.15
Brain	alternative polyA	0	0	1.07
Brain	alternative TSS	0	0	1.07
Brain	gene expression	0	0	1.12
Brain	isoform ratio	0	0	1.15
Brain	intron excision ratio	0	0	1.07
Brain	mRNA stability	0	0	1.12
Eye	alternative polyA	0	0	1.26
Eye	alternative TSS	0	0	1.08
Eye	gene expression	0	0	1.23
Eye	isoform ratio	0	0	1.15
Eye	intron excision ratio	0	0	0.99
Eye	mRNA stability	0	0	1.18
IL	alternative polyA	0	0	1.05
IL	alternative TSS	0	0	1.22
IL	gene expression	0	0	1.13
IL	isoform ratio	0	0	1.09
IL	intron excision ratio	0	0	1.1
IL	mRNA stability	0	0	1.22
LHb	alternative polyA	0	0	1.1
LHb	alternative TSS	0	0	1.15
LHb	gene expression	0	0	1.19
LHb	isoform ratio	0	0	1.09
LHb	intron excision ratio	0	0	1.09
LHb	mRNA stability	0	0	1.17
Liver	alternative polyA	0	0	1.01
Liver	alternative TSS	0	0	1.13
Liver	gene expression	0	0	1.12
Liver	isoform ratio	0	0	1.16
Liver	intron excision ratio	1	0	1.16
Liver	mRNA stability	0	0	1.12
NAcc	alternative polyA	0	0	1.03
NAcc	alternative TSS	0	0	1.16
NAcc	gene expression	0	0	1.13
NAcc	isoform ratio	0	0	1.11
NAcc	intron excision ratio	0	0	1.07
NAcc	mRNA stability	0	0	1.14
OFC	alternative polyA	0	0	1.11
OFC	alternative TSS	0	0	0.95
OFC	gene expression	0	0	1.16
OFC	isoform ratio	0	0	1.12
OFC	intron excision ratio	0	0	1.02
OFC	mRNA stability	0	0	1.2
PL	alternative polyA	0	0	1.05
PL	alternative TSS	2	0.2	1.1
PL	gene expression	0	0	1.13
PL	isoform ratio	0	0	1.12
PL	intron excision ratio	0	0	1.05
PL	mRNA stability	0	0	1.17