Lifetime Intake

Tags: Behavior · Cocaine

Project: p50_paul_meyer_2020

2 loci · 2 genes with independent associations · 2 total associated genes

Significant Loci

#	Chr	Start pos	End pos	# assoc genes	# joint models	Best TWAS P	Best GWAS P	Cond GWAS P	Joint genes
1	chr1	166093700	167491708	1	1	1.47e-12	1.05e-03	6.04e-08	Tead1
2	chr8	33211184	34601262	1	1	2.96e-12	1.72e-01	1.60e-12	Ddx25

Pleiotropic Associations

Trait	Chi² ratio	# genes⁺	# genes⁺⁺	% genes⁺⁺	Corr P	Genes
BMI with tail	1.98	2	0	0	1e+00	Ddx25 Tead1
BMI without tail	4.08	1	0	0	1e+00	Ddx25
Right kidney weight	2.2	1	0	0	1e+00	Ddx25
Tail length	6.06	1	0	0	1e+00	Ddx25
Length without tail	5.12	1	0	0	1e+00	Ddx25
Parametrial fat weight	2.79	1	0	0	1e+00	Ddx25
Tibialis anterior weight	1.5	1	0	0	1e+00	Tead1
Patch foraging indifference point 0 sec	10.57	1	0	0	1e+00	Tead1
Patch foraging total patch changes 0 sec	9.14	1	0	0	1e+00	Tead1
Patch foraging total patch changes 12 sec	9.53	1	0	0	1e+00	Tead1
Patch foraging total patch changes 18 sec	4.38	1	0	0	1e+00	Tead1
Patch foraging total patch changes 6 sec	6.76	1	0	0	1e+00	Tead1
Patch foraging time to switch 0 sec	6.02	1	0	0	1e+00	Tead1
Patch foraging water rate 24 sec	8.95	1	0	0	1e+00	Tead1
Locomotor activity	4.49	1	0	0	1e+00	Ddx25
Locomotor testing distance	4.75	1	0	0	1e+00	Ddx25
Locomotor testing rearing	3.33	1	0	0	1e+00	Ddx25
Reaction time mean minus median AUC	3.91	1	0	0	1e+00	Ddx25
Reaction time mean	4.52	2	0	0	1e+00	Ddx25 Tead1
Reaction time mean AUC	3.97	1	0	0	1e+00	Tead1
Median of all reaction times	4.38	1	0	0	1e+00	Tead1
Conditioned reinforcement - inactives	12.53	2	0	0	1e+00	Ddx25 Tead1
Intermittent access intake day 1-15 change	43.02	2	1	50	1e+00	Ddx25 Tead1
Intermittent access intake escalation	41.26	1	1	50	1e+00	Ddx25
Intermittent access intake escalation 2	20.4	2	1	50	1e+00	Ddx25 Tead1
Intermitt. access day 1 inactive lever presses	17.35	2	1	50	1e+00	Ddx25 Tead1
Intermitt. access day 15 inactive lever presses	25.67	2	1	50	1e+00	Ddx25 Tead1
Intermitt. access escalation Index	14.59	1	0	0	1e+00	Ddx25
Intermittent access day 1 total infusions	56.33	1	1	50	1e+00	Tead1
Intermittent access day 15 total infusions	26.19	2	1	50	1e+00	Ddx25 Tead1
Intermittent access terminal intake (last 3 days)	24.5	2	1	50	1e+00	Ddx25 Tead1
Intermittent access total infusions	35.65	2	2	100	1e+00	Ddx25 Tead1
Intermittent access day 1 locomotion	11.44	1	0	0	1e+00	Tead1
Intermittent access total locomotion	7.22	1	0	0	1e+00	Tead1
Intermittent access standard deviation	15.63	2	0	0	1e+00	Ddx25 Tead1
Cocaine induced anxiety	12.68	1	0	0	1e+00	Ddx25
Baseline Anxiety	5.61	1	0	0	1e+00	Ddx25
Incentive Sensitization - Responses	27.36	2	1	50	1e+00	Ddx25 Tead1
Incentive Sensitization - Breakpoint	27.9	2	1	50	1e+00	Ddx25 Tead1
Progressive ratio test 1 active lever presses	17.35	2	1	50	1e+00	Ddx25 Tead1
Progressive ratio test 1 breakpoint	15.45	2	0	0	1e+00	Ddx25 Tead1
Progressive ratio test 1 inactive lever presses	10.24	2	0	0	1e+00	Ddx25 Tead1
Progressive ratio test 2 active lever presses	30.08	2	1	50	1e+00	Ddx25 Tead1
Progressive ratio test 2 breakpoint	31.55	2	1	50	1e+00	Ddx25 Tead1
Progressive ratio test 2 inactive lever presses	22.46	2	1	50	1e+00	Ddx25 Tead1
Total sessions with >9 infusions	21.06	2	0	0	1e+00	Ddx25 Tead1
Short access day 10 total inactive lever presses	13.19	1	0	0	1e+00	Tead1
Short access day 1 total infusions	31.31	2	1	50	1e+00	Ddx25 Tead1
Short access day 10 total infusions	68.19	2	2	100	1e+00	Ddx25 Tead1
Short access total infusions	54.83	2	2	100	1e+00	Ddx25 Tead1
Short access day 1 locomotion	10.43	1	0	0	1e+00	Tead1
Short access day 10 total locomotion	8.02	2	0	0	1e+00	Ddx25 Tead1
Short access total locomotion	27.61	1	1	50	1e+00	Tead1
Compulsive drug intake	22.25	1	0	0	1e+00	Tead1
One hour access (0.3 mA shock)	70.35	1	1	50	1e+00	Ddx25
One hour access (shock baseline)	22.46	2	1	50	1e+00	Ddx25 Tead1
Number of responses in last shaping day	22.92	2	1	50	1e+00	Ddx25 Tead1
Bone: cortical area	7.52	1	0	0	1e+00	Ddx25
Bone: cortical porosity	5.3	1	0	0	1e+00	Tead1
Bone: cortical porosity	7.17	1	0	0	1e+00	Tead1
Bone: cortical thickness	4.39	1	0	0	1e+00	Ddx25
Bone: cortical thickness	5.77	1	0	0	1e+00	Ddx25
Bone: final force	5.29	1	0	0	1e+00	Ddx25
Bone: final moment	4.65	1	0	0	1e+00	Ddx25
Bone: maximum force	6.75	1	0	0	1e+00	Ddx25
Bone: maximum moment	5.84	1	0	0	1e+00	Ddx25
Bone: minimum diameter	3.6	1	0	0	1e+00	Ddx25
Bone: periosteal estimation	3.75	1	0	0	1e+00	Ddx25
Bone: stiffness	4.98	1	0	0	1e+00	Ddx25
Bone: trabecular thickness	4.3	1	0	0	1e+00	Ddx25
Breakpoint value in progressive ratio session	11.08	1	0	0	1e+00	Tead1
Distance traveled before self-admin	12.14	2	0	0	1e+00	Ddx25 Tead1
Distance traveled after self-admin	11.88	2	0	0	1e+00	Ddx25 Tead1
Delta time in closed arm before/after self-admin	6.42	1	0	0	1e+00	Ddx25
Extinction: sum of active levers before priming	23.79	1	0	0	1e+00	Ddx25
Active lever presses in extinction session 6	9.49	1	0	0	1e+00	Ddx25
Delta distance traveled before/after self-admin	6.76	1	0	0	1e+00	Ddx25
Delta ambulatory time before/after self-admin	14.46	1	0	0	1e+00	Ddx25
Time in closed arm before self-admin	11.48	1	0	0	1e+00	Tead1
Time in closed arm after self-admin	8.36	1	0	0	1e+00	Tead1
Time to tail flick, vehicle, before self-admin	9.26	1	0	0	1e+00	Ddx25
Time to tail flick, test, before self-admin	5.88	1	0	0	1e+00	Ddx25
Delta time to tail flick, vehicle, before/after SA	5.9	1	0	0	1e+00	Tead1
Ambulatory time before self-admin	18.9	2	1	50	1e+00	Ddx25 Tead1
Ambulatory time after self-admin	12.41	2	0	0	1e+00	Ddx25 Tead1
Total heroin consumption	7.85	2	0	0	1e+00	Ddx25 Tead1
Seeking ratio, delayed vs. immediate footshock	5.2	1	0	0	1e+00	Tead1
Run reversals in cocaine runway, males	8.37	1	0	0	1e+00	Ddx25
Latency to leave start box in cocaine runway	5.91	1	0	0	1e+00	Ddx25
Latency to leave start box in cocaine runway, M	10.76	1	0	0	1e+00	Ddx25
Sr content in liver	9.74	1	0	0	1e+00	Ddx25

Associations by panel

Tissue	RNA modality	# hits	Avg chisq
Adipose	alternative polyA	0	1.08
Adipose	alternative TSS	0	1.1
Adipose	gene expression	1	1.12
Adipose	isoform ratio	0	1.14
Adipose	intron excision ratio	0	1.12
Adipose	mRNA stability	0	1.13
BLA	alternative polyA	0	1.13
BLA	alternative TSS	0	1.15
BLA	gene expression	0	1.14
BLA	isoform ratio	0	1.13
BLA	intron excision ratio	0	1.09
BLA	mRNA stability	0	1.18
Brain	alternative polyA	0	1.12
Brain	alternative TSS	0	1.1
Brain	gene expression	0	1.13
Brain	isoform ratio	0	1.14
Brain	intron excision ratio	0	1.12
Brain	mRNA stability	0	1.14
Eye	alternative polyA	0	1.12
Eye	alternative TSS	0	1.08
Eye	gene expression	0	1.22
Eye	isoform ratio	0	1.14
Eye	intron excision ratio	0	1.03
Eye	mRNA stability	0	1.2
IL	alternative polyA	0	1.14
IL	alternative TSS	0	1.09
IL	gene expression	0	1.13
IL	isoform ratio	0	1.14
IL	intron excision ratio	0	1.1
IL	mRNA stability	0	1.21
LHb	alternative polyA	0	1.06
LHb	alternative TSS	0	1.4
LHb	gene expression	0	1.15
LHb	isoform ratio	0	1.22
LHb	intron excision ratio	0	1.06
LHb	mRNA stability	0	1.21
Liver	alternative polyA	0	1.14
Liver	alternative TSS	0	1.2
Liver	gene expression	0	1.13
Liver	isoform ratio	0	1.19
Liver	intron excision ratio	0	1.19
Liver	mRNA stability	0	1.14
NAcc	alternative polyA	0	1.12
NAcc	alternative TSS	1	1.1
NAcc	gene expression	0	1.14
NAcc	isoform ratio	0	1.13
NAcc	intron excision ratio	0	1.12
NAcc	mRNA stability	0	1.16
OFC	alternative polyA	0	1.19
OFC	alternative TSS	0	1.18
OFC	gene expression	0	1.11
OFC	isoform ratio	0	1.13
OFC	intron excision ratio	0	1.04
OFC	mRNA stability	0	1.14
PL	alternative polyA	0	1.12
PL	alternative TSS	0	1.11
PL	gene expression	0	1.13
PL	isoform ratio	0	1.19
PL	intron excision ratio	0	1.12
PL	mRNA stability	0	1.17
pVTA	alternative polyA	0	1.17
pVTA	alternative TSS	0	1.13
pVTA	gene expression	0	1.15
pVTA	isoform ratio	0	1.17
pVTA	intron excision ratio	0	1.13
pVTA	mRNA stability	0	1.25
RMTg	alternative polyA	0	1.13
RMTg	alternative TSS	0	1.12
RMTg	gene expression	0	1.16
RMTg	isoform ratio	0	1.1
RMTg	intron excision ratio	0	1.18
RMTg	mRNA stability	0	1.3