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Condit. Reinf. lever presses

Pavlovian Conditioned Approach, conditioned reinforcement, sign-tracking, number of lever presses (contacts) during the conditoned reinforcement session

Tags: Behavior · Pavlovian conditioned approach · Conditioned reinforcement

Project: p50_paul_meyer_2014

152 significantly associated models · 40 unique genes

Significant Loci

#	chr	p0	p1	# assoc genes	# joint models	best TWAS P	best SNP P	cond SNP P	% var exp	joint genes
1	1	151194048	157352620	40	8	3e-09	3.3e-09	1	100	Numa1 Serpinh1 Ppme1 Mrpl48 Plekhb1 Arap1 Relt Thap12

p0: physical position of the start of the locus. p1: physical position of the end of the locus. # joint models: number of models selected by step-wise conditional analysis.

Pleiotropic Associations

Trait	chisq ratio	# genes⁺	# genes⁺⁺	% genes⁺⁺	corr	corr P	genes
Tail length	5.5	9	0	0	0.99	3.6e-15	C2cd3 Mrpl48 Plekhb1 P2ry6 P2ry2 Fchsd2 Arap1 Art2b Stim1
Length with tail	3.6	1	0	0	0.00	1.0e+00	Stim1
Retroperitoneal fat weight	5.0	18	0	0	-0.99	2.4e-29	Capn5 Emsy Dgat2 Lipt2 Pgm2l1 Ppme1 Ucp2 Dnajb13 Mrpl48 Plekhb1 P2ry6 Rsf1 Relt Mogat2 Tsku Acer3 Thap12 NA
Mean time between licks in bursts	9.5	2	0	0	0.00	1.0e+00	P2ry6 P2ry2
Condit. Reinf. active minus inactive responses	11.3	14	0	0	1.00	3.1e-47	Lipt2 Pgm2l1 Dnajb13 Mrpl48 Plekhb1 Fam168a P2ry6 P2ry2 Fchsd2 Atg16l2 Arap1 Art2b NA NA
Condit. Reinf. active responses	12.4	35	0	0	1.00	9.4e-143	Numa1 Capn5 Gucy2e Emsy Wnt11 Uvrag Dgat2 Serpinh1 Lipt2 Pgm2l1 P4ha3 Ppme1 C2cd3 Tpbgl Dnajb13 Slco2b1 Mrpl48 Plekhb1 Fam168a P2ry6 P2ry2 Fchsd2 Atg16l2 Arap1 Art2b Inppl1 Stim1 Map6 Mogat2 Tsku AABR07004881.1 Arhgef17 Thap12 NA NA
Condit. Reinf. inactive responses	11.2	3	0	0	1.00	5.9e-14	Mrpl48 P2ry2 Arap1
Condit. Reinf. lever reinforcers received	13.2	39	3	38	1.00	1.1e-158	Numa1 Capn5 Gucy2e Emsy Wnt11 Uvrag Dgat2 Serpinh1 Lipt2 Pgm2l1 P4ha3 Ppme1 C2cd3 Ucp2 Tpbgl Dnajb13 Slco2b1 Mrpl48 Plekhb1 Fam168a P2ry6 P2ry2 Fchsd2 Atg16l2 Arap1 Art2b Inppl1 Stim1 Relt Map6 Mogat2 Tsku Acer3 AABR07004881.1 Arhgef17 Thap12 NA NA NA
Pavlov. Cond. lever latency	22.2	40	40	500	-1.00	4.6e-241	Numa1 Capn5 Gucy2e Emsy Wnt11 Uvrag Dgat2 Serpinh1 Lipt2 Pgm2l1 P4ha3 Ppme1 C2cd3 Ucp2 Tpbgl Dnajb13 Slco2b1 Mrpl48 Plekhb1 Fam168a P2ry6 P2ry2 Fchsd2 Atg16l2 Arap1 Art2b Inppl1 Stim1 Rsf1 Relt Map6 Mogat2 Tsku Acer3 AABR07004881.1 Arhgef17 Thap12 NA NA NA
Pavlov. Cond. change in total contacts	16.5	40	7	88	1.00	1.4e-183	Numa1 Capn5 Gucy2e Emsy Wnt11 Uvrag Dgat2 Serpinh1 Lipt2 Pgm2l1 P4ha3 Ppme1 C2cd3 Ucp2 Tpbgl Dnajb13 Slco2b1 Mrpl48 Plekhb1 Fam168a P2ry6 P2ry2 Fchsd2 Atg16l2 Arap1 Art2b Inppl1 Stim1 Rsf1 Relt Map6 Mogat2 Tsku Acer3 AABR07004881.1 Arhgef17 Thap12 NA NA NA
Pavlov. Cond. index score	17.2	40	5	62	1.00	1.1e-215	Numa1 Capn5 Gucy2e Emsy Wnt11 Uvrag Dgat2 Serpinh1 Lipt2 Pgm2l1 P4ha3 Ppme1 C2cd3 Ucp2 Tpbgl Dnajb13 Slco2b1 Mrpl48 Plekhb1 Fam168a P2ry6 P2ry2 Fchsd2 Atg16l2 Arap1 Art2b Inppl1 Stim1 Rsf1 Relt Map6 Mogat2 Tsku Acer3 AABR07004881.1 Arhgef17 Thap12 NA NA NA
Pavlov. Cond. latency score	15.5	40	0	0	1.00	6.2e-204	Numa1 Capn5 Gucy2e Emsy Wnt11 Uvrag Dgat2 Serpinh1 Lipt2 Pgm2l1 P4ha3 Ppme1 C2cd3 Ucp2 Tpbgl Dnajb13 Slco2b1 Mrpl48 Plekhb1 Fam168a P2ry6 P2ry2 Fchsd2 Atg16l2 Arap1 Art2b Inppl1 Stim1 Rsf1 Relt Map6 Mogat2 Tsku Acer3 AABR07004881.1 Arhgef17 Thap12 NA NA NA
Pavlov. Cond. lever contacts	23.2	40	40	500	1.00	8.1e-254	Numa1 Capn5 Gucy2e Emsy Wnt11 Uvrag Dgat2 Serpinh1 Lipt2 Pgm2l1 P4ha3 Ppme1 C2cd3 Ucp2 Tpbgl Dnajb13 Slco2b1 Mrpl48 Plekhb1 Fam168a P2ry6 P2ry2 Fchsd2 Atg16l2 Arap1 Art2b Inppl1 Stim1 Rsf1 Relt Map6 Mogat2 Tsku Acer3 AABR07004881.1 Arhgef17 Thap12 NA NA NA
Pavlov. Cond. magazine entry number	11.8	7	0	0	-1.00	4.0e-10	Capn5 Uvrag Dgat2 Slco2b1 Rsf1 Mogat2 Thap12
Pavlov. Cond. lever-magazine prob. diff.	16.2	40	0	0	1.00	2.5e-218	Numa1 Capn5 Gucy2e Emsy Wnt11 Uvrag Dgat2 Serpinh1 Lipt2 Pgm2l1 P4ha3 Ppme1 C2cd3 Ucp2 Tpbgl Dnajb13 Slco2b1 Mrpl48 Plekhb1 Fam168a P2ry6 P2ry2 Fchsd2 Atg16l2 Arap1 Art2b Inppl1 Stim1 Rsf1 Relt Map6 Mogat2 Tsku Acer3 AABR07004881.1 Arhgef17 Thap12 NA NA NA
Pavlov. Cond. response bias	23.4	40	40	500	1.00	4.2e-229	Numa1 Capn5 Gucy2e Emsy Wnt11 Uvrag Dgat2 Serpinh1 Lipt2 Pgm2l1 P4ha3 Ppme1 C2cd3 Ucp2 Tpbgl Dnajb13 Slco2b1 Mrpl48 Plekhb1 Fam168a P2ry6 P2ry2 Fchsd2 Atg16l2 Arap1 Art2b Inppl1 Stim1 Rsf1 Relt Map6 Mogat2 Tsku Acer3 AABR07004881.1 Arhgef17 Thap12 NA NA NA

chisq ratio: Average Chi² statistic for the selected genes in the secondary trait, divided by the average statistic for all genes in the secondary trait. # genes⁺: Shared significant genes at Bonferroni correction. # genes⁺⁺: Shared significant genes at transcriptome-wide significance. % genes⁺⁺: Number of [++] genes as a percentage of primary trait’s total joint genes. corr: Correlation of effect sizes across the [+] genes.

Associations by panel

tissue	modality	# hits	% hits/tests	avg chisq
Adipose	alternative polyA	8	0.377	1.4
Adipose	alternative TSS	6	0.372	1.6
Adipose	gene expression	10	0.120	1.3
Adipose	isoform ratio	2	0.071	1.3
Adipose	intron excision ratio	5	0.171	1.3
Adipose	mRNA stability	4	0.116	1.4
BLA	alternative polyA	0	0.000	1.4
BLA	alternative TSS	4	0.475	1.7
BLA	gene expression	7	0.115	1.4
BLA	isoform ratio	0	0.000	1.3
BLA	intron excision ratio	2	0.067	1.3
BLA	mRNA stability	3	0.148	1.4
Brain	alternative polyA	0	0.000	1.4
Brain	alternative TSS	4	0.233	1.4
Brain	gene expression	10	0.110	1.4
Brain	isoform ratio	3	0.095	1.3
Brain	intron excision ratio	5	0.093	1.3
Brain	mRNA stability	7	0.160	1.4
Eye	alternative polyA	0	0.000	1.2
Eye	alternative TSS	1	0.417	1.6
Eye	gene expression	1	0.089	1.4
Eye	isoform ratio	0	0.000	1.5
Eye	intron excision ratio	1	0.163	1.4
Eye	mRNA stability	1	0.429	1.7
IL	alternative polyA	0	0.000	1.3
IL	alternative TSS	0	0.000	1.4
IL	gene expression	5	0.137	1.4
IL	isoform ratio	0	0.000	1.4
IL	intron excision ratio	1	0.104	1.3
IL	mRNA stability	0	0.000	1.3
LHb	alternative polyA	0	0.000	1.3
LHb	alternative TSS	0	0.000	1.4
LHb	gene expression	2	0.062	1.4
LHb	isoform ratio	0	0.000	1.3
LHb	intron excision ratio	0	0.000	1.3
LHb	mRNA stability	0	0.000	1.4
Liver	alternative polyA	6	0.399	1.4
Liver	alternative TSS	1	0.066	1.4
Liver	gene expression	7	0.097	1.4
Liver	isoform ratio	1	0.042	1.3
Liver	intron excision ratio	7	0.160	1.4
Liver	mRNA stability	5	0.204	1.4
NAcc	alternative polyA	0	0.000	1.5
NAcc	alternative TSS	0	0.000	1.5
NAcc	gene expression	8	0.127	1.4
NAcc	isoform ratio	0	0.000	1.4
NAcc	intron excision ratio	2	0.065	1.4
NAcc	mRNA stability	5	0.221	1.5
OFC	alternative polyA	0	0.000	1.4
OFC	alternative TSS	0	0.000	1.3
OFC	gene expression	2	0.054	1.4
OFC	isoform ratio	0	0.000	1.4
OFC	intron excision ratio	0	0.000	1.3
OFC	mRNA stability	1	0.093	1.4
PL	alternative polyA	0	0.000	1.4
PL	alternative TSS	0	0.000	1.5
PL	gene expression	9	0.122	1.4
PL	isoform ratio	0	0.000	1.3
PL	intron excision ratio	0	0.000	1.3
PL	mRNA stability	6	0.206	1.5

avg chisq: Average Chi² (squared Z-score) across all models in this panel for this trait.