Hub : Traits

Condit. Reinf. lever presses

Pavlovian Conditioned Approach, conditioned reinforcement, sign-tracking, number of lever presses (contacts) during the conditoned reinforcement session

Tags: Behavior · Pavlovian conditioned approach · Conditioned reinforcement

Project: p50_paul_meyer_2014

1 locus · 5 genes with independent associations · 151 total associated genes

Significant Loci

#	Chr	Start pos	End pos	# assoc genes	# joint models	Best TWAS P	Best GWAS P	Cond GWAS P	Joint genes
1	chr1	151412751	157139855	151	5	1.92e-09	3.33e-09	1e+00	Arap1 Capn5 LOC102553078 LOC120099890 Mrpl48

Pleiotropic Associations

Trait	Chi2 ratio	# genes+	# genes++	% genes++	Corr	Corr P	Genes
Tail length	5.8	15	0	0	1	1.16e-17	Arap1 Art2b Atg16l2 Clpb Lamtor1 LOC120097346 LOC120097348 Numa1 P2ry2 P2ry6 Rnf121 Serpinh1 Slco2b1 Thap12 Xndc1
Retroperitoneal fat weight	5.24	14	0	0	-1	1.96e-27	Acer3 Capn5 Dgat2 Dnajb13 LOC100912071 LOC103691200 LOC120099889 Lrrc32 Pgm2l1 Plekhb1 Thap12 Tsku Ucp2 Uvrag
Mean time between licks in bursts	10.59	1	0	0	0	1.00e+00	Uvrag
Condit. Reinf. active minus inactive responses	12.08	8	0	0	1	2.23e-16	Arap1 Atg16l2 Clpb Lamtor1 LOC120097348 Numa1 Plekhb1 Relt
Condit. Reinf. active responses	12.42	50	0	0	1	7.15e-224	Arap1 Arhgef17 Arrb1 Art2b Atg16l2 Capn5 Clpb Dgat2 Dnajb13 Emsy Fam168a Fchsd2 Folr2 Gdpd4 Gdpd5 Gucy2e Lamtor1 Lipt2 LOC102553078 LOC120097346 LOC120097348 LOC120099888 LOC120099889 LOC120099891 LOC120099895 LOC120099897 Map6 Mogat2 Mrpl48 Numa1 Olr35 P2ry2 P2ry6 P4ha3 Pak1 Pgm2l1 Plekhb1 Pold3 Ppme1 Relt Rnf121 Rnf169 Serpinh1 Slco2b1 Thap12 Tsku Ucp2 Uvrag Wnt11 Xndc1
Condit. Reinf. inactive responses	11.45	3	0	0	1	7.70e-05	Atg16l2 Plekhb1 Relt
Condit. Reinf. lever reinforcers received	12.93	54	2	40	1	1.48e-285	Arap1 Arhgef17 Arrb1 Art2b Atg16l2 Capn5 Clpb Dgat2 Dnajb13 Emsy Fam168a Fchsd2 Folr2 Gdpd4 Gdpd5 Gucy2e Lamtor1 Lipt2 LOC100912071 LOC102553078 LOC103691200 LOC120097346 LOC120097348 LOC120099888 LOC120099889 LOC120099890 LOC120099891 LOC120099895 LOC120099897 Map6 Mogat2 Mrpl48 Numa1 Olr35 P2ry2 P2ry6 P4ha3 Pak1 Pgm2l1 Plekhb1 Pold3 Ppme1 Relt Rnf121 Rnf169 Rps3 Serpinh1 Slco2b1 Thap12 Tsku Ucp2 Uvrag Wnt11 Xndc1
Pavlov. Cond. lever latency	22.27	56	55	1100	-1	0.00e+00	Acer3 Arap1 Arhgef17 Arrb1 Art2b Atg16l2 Capn5 Clpb Dgat2 Dnajb13 Emsy Fam168a Fchsd2 Folr2 Gdpd4 Gdpd5 Gucy2e Lamtor1 Lipt2 LOC100912071 LOC102553078 LOC103691200 LOC120097346 LOC120097348 LOC120099888 LOC120099889 LOC120099890 LOC120099891 LOC120099895 LOC120099897 Lrrc32 Map6 Mogat2 Mrpl48 Numa1 Olr35 P2ry2 P2ry6 P4ha3 Pak1 Pgm2l1 Plekhb1 Pold3 Ppme1 Relt Rnf121 Rnf169 Rps3 Serpinh1 Slco2b1 Thap12 Tsku Ucp2 Uvrag Wnt11 Xndc1
Pavlov. Cond. change in total contacts	16.05	56	9	180	1	1.28e-316	Acer3 Arap1 Arhgef17 Arrb1 Art2b Atg16l2 Capn5 Clpb Dgat2 Dnajb13 Emsy Fam168a Fchsd2 Folr2 Gdpd4 Gdpd5 Gucy2e Lamtor1 Lipt2 LOC100912071 LOC102553078 LOC103691200 LOC120097346 LOC120097348 LOC120099888 LOC120099889 LOC120099890 LOC120099891 LOC120099895 LOC120099897 Lrrc32 Map6 Mogat2 Mrpl48 Numa1 Olr35 P2ry2 P2ry6 P4ha3 Pak1 Pgm2l1 Plekhb1 Pold3 Ppme1 Relt Rnf121 Rnf169 Rps3 Serpinh1 Slco2b1 Thap12 Tsku Ucp2 Uvrag Wnt11 Xndc1
Pavlov. Cond. index score	17.41	56	1	20	1	0.00e+00	Acer3 Arap1 Arhgef17 Arrb1 Art2b Atg16l2 Capn5 Clpb Dgat2 Dnajb13 Emsy Fam168a Fchsd2 Folr2 Gdpd4 Gdpd5 Gucy2e Lamtor1 Lipt2 LOC100912071 LOC102553078 LOC103691200 LOC120097346 LOC120097348 LOC120099888 LOC120099889 LOC120099890 LOC120099891 LOC120099895 LOC120099897 Lrrc32 Map6 Mogat2 Mrpl48 Numa1 Olr35 P2ry2 P2ry6 P4ha3 Pak1 Pgm2l1 Plekhb1 Pold3 Ppme1 Relt Rnf121 Rnf169 Rps3 Serpinh1 Slco2b1 Thap12 Tsku Ucp2 Uvrag Wnt11 Xndc1
Pavlov. Cond. latency score	15.67	56	0	0	1	0.00e+00	Acer3 Arap1 Arhgef17 Arrb1 Art2b Atg16l2 Capn5 Clpb Dgat2 Dnajb13 Emsy Fam168a Fchsd2 Folr2 Gdpd4 Gdpd5 Gucy2e Lamtor1 Lipt2 LOC100912071 LOC102553078 LOC103691200 LOC120097346 LOC120097348 LOC120099888 LOC120099889 LOC120099890 LOC120099891 LOC120099895 LOC120099897 Lrrc32 Map6 Mogat2 Mrpl48 Numa1 Olr35 P2ry2 P2ry6 P4ha3 Pak1 Pgm2l1 Plekhb1 Pold3 Ppme1 Relt Rnf121 Rnf169 Rps3 Serpinh1 Slco2b1 Thap12 Tsku Ucp2 Uvrag Wnt11 Xndc1
Pavlov. Cond. lever contacts	23.38	56	56	1120	1	0.00e+00	Acer3 Arap1 Arhgef17 Arrb1 Art2b Atg16l2 Capn5 Clpb Dgat2 Dnajb13 Emsy Fam168a Fchsd2 Folr2 Gdpd4 Gdpd5 Gucy2e Lamtor1 Lipt2 LOC100912071 LOC102553078 LOC103691200 LOC120097346 LOC120097348 LOC120099888 LOC120099889 LOC120099890 LOC120099891 LOC120099895 LOC120099897 Lrrc32 Map6 Mogat2 Mrpl48 Numa1 Olr35 P2ry2 P2ry6 P4ha3 Pak1 Pgm2l1 Plekhb1 Pold3 Ppme1 Relt Rnf121 Rnf169 Rps3 Serpinh1 Slco2b1 Thap12 Tsku Ucp2 Uvrag Wnt11 Xndc1
Pavlov. Cond. magazine entry number	12.5	2	0	0	-1	5.31e-05	Arap1 Capn5
Pavlov. Cond. lever-magazine prob. diff.	16.29	56	0	0	1	0.00e+00	Acer3 Arap1 Arhgef17 Arrb1 Art2b Atg16l2 Capn5 Clpb Dgat2 Dnajb13 Emsy Fam168a Fchsd2 Folr2 Gdpd4 Gdpd5 Gucy2e Lamtor1 Lipt2 LOC100912071 LOC102553078 LOC103691200 LOC120097346 LOC120097348 LOC120099888 LOC120099889 LOC120099890 LOC120099891 LOC120099895 LOC120099897 Lrrc32 Map6 Mogat2 Mrpl48 Numa1 Olr35 P2ry2 P2ry6 P4ha3 Pak1 Pgm2l1 Plekhb1 Pold3 Ppme1 Relt Rnf121 Rnf169 Rps3 Serpinh1 Slco2b1 Thap12 Tsku Ucp2 Uvrag Wnt11 Xndc1
Pavlov. Cond. response bias	23.56	56	56	1120	1	0.00e+00	Acer3 Arap1 Arhgef17 Arrb1 Art2b Atg16l2 Capn5 Clpb Dgat2 Dnajb13 Emsy Fam168a Fchsd2 Folr2 Gdpd4 Gdpd5 Gucy2e Lamtor1 Lipt2 LOC100912071 LOC102553078 LOC103691200 LOC120097346 LOC120097348 LOC120099888 LOC120099889 LOC120099890 LOC120099891 LOC120099895 LOC120099897 Lrrc32 Map6 Mogat2 Mrpl48 Numa1 Olr35 P2ry2 P2ry6 P4ha3 Pak1 Pgm2l1 Plekhb1 Pold3 Ppme1 Relt Rnf121 Rnf169 Rps3 Serpinh1 Slco2b1 Thap12 Tsku Ucp2 Uvrag Wnt11 Xndc1

Associations by panel

Tissue	RNA modality	# hits	% hits/tests	Avg chisq
Adipose	alternative polyA	13	0.4	1.33
Adipose	alternative TSS	12	0.4	1.46
Adipose	gene expression	12	0.1	1.35
Adipose	isoform ratio	13	0.3	1.38
Adipose	intron excision ratio	3	0.1	1.23
Adipose	mRNA stability	9	0.2	1.36
BLA	alternative polyA	2	0.1	1.42
BLA	alternative TSS	7	0.4	1.43
BLA	gene expression	10	0.1	1.4
BLA	isoform ratio	0	0	1.4
BLA	intron excision ratio	2	0.1	1.33
BLA	mRNA stability	4	0.2	1.38
Brain	alternative polyA	2	0.1	1.35
Brain	alternative TSS	5	0.1	1.32
Brain	gene expression	12	0.1	1.36
Brain	isoform ratio	5	0.1	1.35
Brain	intron excision ratio	7	0.1	1.29
Brain	mRNA stability	8	0.1	1.35
Eye	alternative polyA	0	0	1.27
Eye	alternative TSS	2	0.5	1.47
Eye	gene expression	3	0.2	1.42
Eye	isoform ratio	0	0	1.29
Eye	intron excision ratio	1	0.1	1.38
Eye	mRNA stability	0	0	1.34
IL	alternative polyA	0	0	1.24
IL	alternative TSS	0	0	1.29
IL	gene expression	5	0.1	1.4
IL	isoform ratio	0	0	1.38
IL	intron excision ratio	1	0.1	1.26
IL	mRNA stability	0	0	1.34
LHb	alternative polyA	0	0	1.35
LHb	alternative TSS	0	0	1.42
LHb	gene expression	1	0	1.37
LHb	isoform ratio	2	0.2	1.31
LHb	intron excision ratio	0	0	1.27
LHb	mRNA stability	0	0	1.28
Liver	alternative polyA	1	0	1.26
Liver	alternative TSS	4	0.1	1.36
Liver	gene expression	12	0.2	1.41
Liver	isoform ratio	6	0.2	1.33
Liver	intron excision ratio	8	0.2	1.36
Liver	mRNA stability	2	0.1	1.34
NAcc	alternative polyA	2	0.1	1.41
NAcc	alternative TSS	5	0.2	1.33
NAcc	gene expression	8	0.1	1.4
NAcc	isoform ratio	4	0.1	1.37
NAcc	intron excision ratio	3	0.1	1.3
NAcc	mRNA stability	6	0.2	1.38
OFC	alternative polyA	0	0	1.27
OFC	alternative TSS	0	0	1.34
OFC	gene expression	2	0	1.38
OFC	isoform ratio	2	0.1	1.36
OFC	intron excision ratio	0	0	1.2
OFC	mRNA stability	1	0.1	1.43
PL	alternative polyA	7	0.2	1.51
PL	alternative TSS	3	0.1	1.35
PL	gene expression	11	0.1	1.38
PL	isoform ratio	4	0.1	1.37
PL	intron excision ratio	3	0.1	1.33
PL	mRNA stability	4	0.1	1.37
pVTA	alternative polyA	2	0.1	1.4
pVTA	alternative TSS	3	0.2	1.34
pVTA	gene expression	8	0.2	1.39
pVTA	isoform ratio	4	0.2	1.36
pVTA	intron excision ratio	4	0.1	1.32
pVTA	mRNA stability	3	0.2	1.35
RMTg	alternative polyA	0	0	1.27
RMTg	alternative TSS	0	0	1.32
RMTg	gene expression	0	0	1.34
RMTg	isoform ratio	0	0	1.23
RMTg	intron excision ratio	0	0	1.45
RMTg	mRNA stability	0	0	1.35