Hub : Traits

Social time

Social time indicated by average time that the rat spent with its head in the observation port providing access to the stimulus rat while the sliding door was open in the last three 18-minute sessions for males and females [cs]

Tags: Behavior · Social reinforcement

Project: p50_david_dietz

1 significantly associated model · 1 unique gene

Significant Loci

# chr p0 p1 # assoc genes # joint models best TWAS P best SNP P cond SNP P % var exp joint genes
1 10 46789397 48185455 1 1 5.9e-09 0.098 1.3e-54 -8731 Trim16

p0: physical position of the start of the locus. p1: physical position of the end of the locus. # joint models: number of models selected by step-wise conditional analysis.

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Epididymis fat weight 1.7 1 0 0 0 1 Trim16
Heart weight 7.8 1 0 0 0 1 Trim16
Liver weight, left 7.8 1 0 0 0 1 Trim16
Intraocular pressure 38.8 1 1 100 0 1 Trim16
Soleus weight 1.7 1 0 0 0 1 Trim16
Tibia length 1.4 1 0 0 0 1 Trim16
Number of licking bursts 19.2 1 0 0 0 1 Trim16
Food consumed during 24 hour testing period 18.6 1 0 0 0 1 Trim16
Times rat made contact with spout 16.5 1 0 0 0 1 Trim16
Mean num. licks in bursts 46.0 1 1 100 0 1 Trim16
Std. dev. time between licks in bursts 5.4 1 0 0 0 1 Trim16
Water consumed over 24 hours 23.8 1 1 100 0 1 Trim16
Indifference point 0 sec 7.9 1 0 0 0 1 Trim16
Delay discounting total patch changes 0 sec 8.5 1 0 0 0 1 Trim16
Delay discounting total patch changes 18 sec 45.7 1 1 100 0 1 Trim16
Delay discounting total patch changes 6 sec 5.0 1 0 0 0 1 Trim16
Delay discounting water rate 0 sec 15.1 1 0 0 0 1 Trim16
Delay discounting water rate 24 sec 3.1 1 0 0 0 1 Trim16
Delay discounting water rate 6 sec 7.2 1 0 0 0 1 Trim16
Locomotor activity 4.9 1 0 0 0 1 Trim16
Reaction time number correct 7.5 1 0 0 0 1 Trim16
Reaction time mean minus median 3.0 1 0 0 0 1 Trim16
Reaction time trials correct on left 7.5 1 0 0 0 1 Trim16
Reaction time trials on left 6.9 1 0 0 0 1 Trim16
Reaction time omissions 3.1 1 0 0 0 1 Trim16
Reaction time false alarm rate 3.1 1 0 0 0 1 Trim16
Reaction time premature initiation rate 5.8 1 0 0 0 1 Trim16
Reaction time trials completed 6.9 1 0 0 0 1 Trim16
Reaction time trials AUC 6.0 1 0 0 0 1 Trim16
Social responses 4.0 1 0 0 0 1 Trim16
Cocaine response after cond. corrected 14.6 1 0 0 0 1 Trim16
Cocaine response after cond. not corrected 16.0 1 0 0 0 1 Trim16
Condit. Reinf. lever presses 7.4 1 0 0 0 1 Trim16
Conditioned reinforcement - actives 4.6 1 0 0 0 1 Trim16
Intermitt. access day 1 inactive lever presses 36.6 1 1 100 0 1 Trim16
Intermitt. access escalation Index 27.6 1 0 0 0 1 Trim16
Intermittent access day 1 locomotion 12.8 1 0 0 0 1 Trim16
Intermittent access total locomotion 9.9 1 0 0 0 1 Trim16
Intermittent access standard deviation 4.0 1 0 0 0 1 Trim16
Cocaine induced anxiety 31.7 1 1 100 0 1 Trim16
Post-drug Anxiety 10.6 1 0 0 0 1 Trim16
Baseline Anxiety 29.9 1 1 100 0 1 Trim16
Progressive ratio test 1 inactive lever presses 10.6 1 0 0 0 1 Trim16
Total sessions with >9 infusions 13.7 1 0 0 0 1 Trim16
Short access day 1 total inactive lever presses 13.8 1 0 0 0 1 Trim16
Short access day 1 total infusions 62.7 1 1 100 0 1 Trim16
Short access total infusions 5.0 1 0 0 0 1 Trim16
Short access day 1 locomotion 33.1 1 1 100 0 1 Trim16
Short access day 10 total locomotion 14.3 1 0 0 0 1 Trim16
Short access total locomotion 10.1 1 0 0 0 1 Trim16
Compulsive drug intake 11.9 1 0 0 0 1 Trim16
Number of responses in last shaping day 25.6 1 1 100 0 1 Trim16
Context. condit. distance diff. score 5.0 1 0 0 0 1 Trim16
Locomotion distance, session 1 31.9 1 1 100 0 1 Trim16
Locomotion distance, session 2 15.7 1 0 0 0 1 Trim16
Locomotion velocity, session 7 5.0 1 0 0 0 1 Trim16
Stereotopy head waving bouts, day 7 25.4 1 1 100 0 1 Trim16
Stereotopy head waving duration, day 7 6.5 1 0 0 0 1 Trim16
Degree of sensitization stereotypy 7.4 1 0 0 0 1 Trim16
Condit. Reinf. active minus inactive responses 5.1 1 0 0 0 1 Trim16
Condit. Reinf. active-inactive response ratio 5.1 1 0 0 0 1 Trim16
Incentive salience index mean 5.9 1 0 0 0 1 Trim16
Time in familiar zone, hab. session 1 6.6 1 0 0 0 1 Trim16
Time in novel zone, hab. session 1 5.6 1 0 0 0 1 Trim16
Total zone transitions, hab. session 1 37.4 1 1 100 0 1 Trim16
Total locomotion distance, hab. session 1 38.5 1 1 100 0 1 Trim16
Locomotion velocity, hab. session 1 30.2 1 1 100 0 1 Trim16
Time in familiar zone, hab. session 2 8.6 1 0 0 0 1 Trim16
Time in novel zone, hab. session 2 4.2 1 0 0 0 1 Trim16
Total locomotion distance, hab. session 2 11.5 1 0 0 0 1 Trim16
Locomotion velocity, hab. session 2 10.0 1 0 0 0 1 Trim16
Time in novel zone, NPP test 5.2 1 0 0 0 1 Trim16
Total zone transitions, NPP test 3.6 1 0 0 0 1 Trim16
Total locomotion distance, NPP test 4.5 1 0 0 0 1 Trim16
Locomotion velocity, NPP test 4.0 1 0 0 0 1 Trim16
Pavlov. Cond. magazine entry latency 30.9 1 1 100 0 1 Trim16
Pavlov. Cond. index score 10.8 1 0 0 0 1 Trim16
Pavlov. Cond. latency score 5.9 1 0 0 0 1 Trim16
Pavlov. Cond. magazine entry number 28.0 1 1 100 0 1 Trim16
Pavlov. Cond. intertrial magazine entries 14.4 1 0 0 0 1 Trim16
Pavlov. Cond. lever-magazine prob. diff. 10.2 1 0 0 0 1 Trim16
Pavlov. Cond. response bias 8.3 1 0 0 0 1 Trim16
Bone: cortical apparent density 18.1 1 0 0 0 1 Trim16
Bone: cortical porosity 21.5 1 0 0 0 1 Trim16
Bone: cortical porosity 27.4 1 1 100 0 1 Trim16
Bone: cortical tissue density 19.6 1 0 0 0 1 Trim16
Bone: elastic displacement 4.3 1 0 0 0 1 Trim16
Bone: elastic work 5.8 1 0 0 0 1 Trim16
Bone: post-yield work 16.2 1 0 0 0 1 Trim16
Bone: tissue strength 7.4 1 0 0 0 1 Trim16
Bone: trabecular tissue density 3.0 1 0 0 0 1 Trim16
Delay disc. indifference point, 16s delay 6.6 1 0 0 0 1 Trim16
Distance moved, locomotor task time 2 6.6 1 0 0 0 1 Trim16
Food seeking constrained by brief footshock 4.2 1 0 0 0 1 Trim16
Run reversals in cocaine runway, females 11.6 1 0 0 0 1 Trim16
Run reversals in cocaine runway, males 6.2 1 0 0 0 1 Trim16
Latency to leave start box in cocaine runway 10.7 1 0 0 0 1 Trim16
Latency to leave start box in cocaine runway, F 7.3 1 0 0 0 1 Trim16
Cu content in liver 6.2 1 0 0 0 1 Trim16
K content in liver 8.3 1 0 0 0 1 Trim16
Mg content in liver 28.9 1 1 100 0 1 Trim16
Mn content in liver 4.4 1 0 0 0 1 Trim16
Rb content in liver 24.8 1 1 100 0 1 Trim16
Se content in liver 19.8 1 0 0 0 1 Trim16
Zn content in liver 3.7 1 0 0 0 1 Trim16

chisq ratio: Average Chi2 statistic for the selected genes in the secondary trait, divided by the average statistic for all genes in the secondary trait. # genes+: Shared significant genes at Bonferroni correction. # genes++: Shared significant genes at transcriptome-wide significance. % genes++: Number of [++] genes as a percentage of primary trait’s total joint genes. corr: Correlation of effect sizes across the [+] genes.

Associations by panel

tissue modality # hits % hits/tests avg chisq
Adipose alternative polyA 0 0.000 1.3
Adipose alternative TSS 0 0.000 1.4
Adipose gene expression 0 0.000 1.3
Adipose isoform ratio 0 0.000 1.3
Adipose intron excision ratio 0 0.000 1.4
Adipose mRNA stability 0 0.000 1.3
BLA alternative polyA 0 0.000 1.2
BLA alternative TSS 0 0.000 1.3
BLA gene expression 0 0.000 1.3
BLA isoform ratio 0 0.000 1.3
BLA intron excision ratio 0 0.000 1.4
BLA mRNA stability 0 0.000 1.3
Brain alternative polyA 0 0.000 1.2
Brain alternative TSS 0 0.000 1.3
Brain gene expression 0 0.000 1.3
Brain isoform ratio 0 0.000 1.3
Brain intron excision ratio 0 0.000 1.4
Brain mRNA stability 0 0.000 1.3
Eye alternative polyA 0 0.000 1.3
Eye alternative TSS 0 0.000 1.2
Eye gene expression 0 0.000 1.4
Eye isoform ratio 0 0.000 1.3
Eye intron excision ratio 0 0.000 1.5
Eye mRNA stability 0 0.000 1.6
IL alternative polyA 0 0.000 1.1
IL alternative TSS 0 0.000 1.1
IL gene expression 0 0.000 1.3
IL isoform ratio 0 0.000 1.4
IL intron excision ratio 0 0.000 1.3
IL mRNA stability 0 0.000 1.3
LHb alternative polyA 0 0.000 1.1
LHb alternative TSS 0 0.000 1.2
LHb gene expression 0 0.000 1.3
LHb isoform ratio 0 0.000 1.3
LHb intron excision ratio 0 0.000 1.5
LHb mRNA stability 0 0.000 1.3
Liver alternative polyA 0 0.000 1.2
Liver alternative TSS 0 0.000 1.3
Liver gene expression 0 0.000 1.3
Liver isoform ratio 0 0.000 1.3
Liver intron excision ratio 0 0.000 1.4
Liver mRNA stability 0 0.000 1.3
NAcc alternative polyA 0 0.000 1.2
NAcc alternative TSS 0 0.000 1.4
NAcc gene expression 0 0.000 1.3
NAcc isoform ratio 0 0.000 1.3
NAcc intron excision ratio 0 0.000 1.3
NAcc mRNA stability 0 0.000 1.3
OFC alternative polyA 0 0.000 1.1
OFC alternative TSS 0 0.000 1.3
OFC gene expression 0 0.000 1.3
OFC isoform ratio 0 0.000 1.3
OFC intron excision ratio 0 0.000 1.4
OFC mRNA stability 0 0.000 1.4
PL alternative polyA 0 0.000 1.2
PL alternative TSS 0 0.000 1.2
PL gene expression 1 0.014 1.3
PL isoform ratio 0 0.000 1.3
PL intron excision ratio 0 0.000 1.4
PL mRNA stability 0 0.000 1.3

avg chisq: Average Chi2 (squared Z-score) across all models in this panel for this trait.