Hub : Genes

Ppme1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 PL mRNA stability Ppme1 0.06 0.04 1.5e-05 0.04 0.04 0.04 0.03 5.1e-05 8.0e-05 6.0e-05 1.1e-04
2 Brain mRNA stability Ppme1 0.28 0.14 0.0e+00 0.22 0.24 0.24 0.24 5.8e-20 2.0e-22 2.7e-22 2.9e-22
3 NAcc mRNA stability Ppme1 0.03 0.02 1.3e-03 0.02 0.02 0.01 0.01 1.7e-03 1.1e-03 5.0e-03 2.8e-03
4 Liver gene expression Ppme1 0.03 0.03 7.7e-04 0.02 0.01 0.01 0.01 2.1e-03 2.7e-02 5.8e-02 2.4e-02
5 NAcc alternative TSS NM_001191838.1 0.03 0.03 8.8e-03 0.01 0.01 0 0.01 3.3e-03 2.7e-02 5.0e-02 2.0e-02
6 NAcc alternative TSS XM_063267176.1 0.03 0.03 8.2e-03 0.01 0.01 0.01 0.01 1.9e-03 8.8e-03 2.9e-02 1.1e-02
7 NAcc isoform ratio NM_001191838.1 0.03 0.03 3.5e-03 0.02 0.01 0 0.01 1.7e-03 1.3e-02 4.3e-02 5.7e-03
8 NAcc isoform ratio XM_063267176.1 0.03 0.03 9.1e-03 0.01 0 0 0.01 5.5e-03 4.7e-02 9.0e-02 2.4e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8
Bone: apparent density0.40.70.9-0.80.50.9-0.2-1.01.0-1.01.0
Area under the delay curve0.10.10.2-0.10.2-0.10.30.5-0.50.5-0.5
BMI with tail1.03.45.60.80.1-1.41.52.4-2.42.4-2.4
BMI without tail1.05.58.51.6-0.7-2.41.32.9-2.92.9-2.9
Body weight1.67.111.61.3-0.2-2.31.83.4-3.43.4-3.4
Weight adjusted by age0.20.71.10.6-0.3-0.80.21.1-1.11.1-1.1
Bone surface0.30.61.41.2-1.1-1.0-0.70.5-0.50.5-0.5
Bone volume0.10.20.50.7-0.7-0.6-0.50.2-0.20.2-0.2
Breakpoint value in progressive ratio session0.71.22.4-1.41.01.50.3-1.01.0-1.01.0
Number of licking bursts0.92.97.8-2.32.81.72.60.1-0.10.1-0.1
Context. condit. distance diff. score1.11.43.81.5-2.0-1.0-1.9-0.30.3-0.30.3
Locomotion velocity, session 10.91.01.5-0.70.31.0-0.5-1.21.2-1.21.2
Locomotion distance, session 10.50.62.00.8-1.1-0.4-1.4-0.50.5-0.50.5
Locomotion velocity, session 20.10.10.10.4-0.3-0.4-0.10.3-0.30.3-0.3
Locomotion distance, session 20.20.31.00.8-0.9-0.5-1.0-0.10.1-0.10.1
Locomotion velocity, session 30.60.71.90.6-1.0-0.1-1.4-0.80.8-0.80.8
Locomotion distance, session 31.01.23.20.7-1.2-0.1-1.8-1.01.0-1.01.0
Stereotopy head waving bouts, day 30.40.41.2-0.50.80.01.10.6-0.60.6-0.6
Stereotopy head waving duration, day 30.10.10.20.2-0.4-0.1-0.5-0.20.2-0.20.2
Locomotion velocity, session 70.30.40.6-0.60.50.70.1-0.70.7-0.70.7
Locomotion distance, session 70.10.10.2-0.50.50.30.4-0.10.1-0.10.1
Stereotopy head waving bouts, day 71.31.54.11.7-2.0-1.1-2.0-0.20.2-0.20.2
Stereotopy head waving duration, day 71.51.95.02.0-2.2-1.5-1.90.3-0.30.3-0.3
Locomotion velocity, session 80.40.41.20.9-1.1-0.6-1.00.0-0.00.0-0.0
Locomotion distance, session 81.21.74.61.8-2.2-1.3-1.90.1-0.10.1-0.1
Degree of sensitization distance1.81.93.6-0.31.0-0.51.91.6-1.61.6-1.6
Degree of sensitization stereotypy2.73.08.32.5-2.9-1.7-2.70.0-0.00.0-0.0
Conditioned locomotion0.40.40.7-0.40.20.7-0.4-0.80.8-0.80.8
Cocaine response after cond. corrected0.81.23.5-1.31.70.71.90.5-0.50.5-0.5
Cocaine response after cond. not corrected0.20.30.9-0.70.80.41.00.3-0.30.3-0.3
Cocaine response before conditioning1.21.44.11.3-1.8-0.6-2.0-0.70.7-0.70.7
Saline control response1.31.72.91.7-1.6-1.7-0.71.1-1.11.1-1.1
Bone: connectivity density0.40.71.1-0.40.00.7-0.7-1.11.1-1.11.1
Bone: cortical apparent density0.81.23.5-1.61.91.11.6-0.00.0-0.00.0
Bone: cortical area0.30.50.70.7-0.3-0.80.20.8-0.80.8-0.8
Bone: cortical porosity0.60.71.50.4-0.90.1-1.2-0.90.9-0.90.9
Bone: cortical porosity0.60.71.70.5-1.0-0.0-1.3-0.80.8-0.80.8
Bone: cortical thickness0.20.40.7-0.80.80.80.4-0.50.5-0.50.5
Bone: cortical thickness0.10.10.30.4-0.4-0.1-0.5-0.20.2-0.20.2
Bone: cortical tissue density0.81.23.4-1.61.81.21.5-0.20.2-0.20.2
Condit. Reinf. active minus inactive responses0.50.60.90.6-0.3-0.80.30.9-0.90.9-0.9
Condit. Reinf. active-inactive response ratio1.01.11.41.0-0.6-1.20.11.2-1.21.2-1.2
Condit. Reinf. active responses0.10.20.30.20.0-0.30.30.5-0.50.5-0.5
Condit. Reinf. inactive responses0.10.10.1-0.30.20.3-0.0-0.30.3-0.30.3
Incentive salience index mean0.40.60.70.7-0.4-0.90.10.9-0.90.9-0.9
Condit. Reinf. lever presses0.20.20.40.7-0.5-0.6-0.30.4-0.40.4-0.4
Condit. Reinf. active minus inactive responses4.67.113.53.7-3.2-3.5-1.72.1-2.12.1-2.1
Condit. Reinf. active-inactive response ratio0.71.22.41.5-1.4-1.4-0.80.7-0.70.7-0.7
Condit. Reinf. active responses7.510.819.74.4-3.8-4.3-1.92.8-2.82.8-2.8
Condit. Reinf. inactive responses4.16.110.43.2-2.7-3.2-1.22.2-2.22.2-2.2
Condit. Reinf. lever presses10.915.932.55.7-5.4-5.2-3.42.6-2.62.6-2.6
Condit. Reinf. lever reinforcers received8.411.822.04.7-4.1-4.5-2.12.8-2.82.8-2.8
Conditioned reinforcement - actives0.31.02.91.3-1.7-0.8-1.6-0.30.3-0.30.3
Conditioned reinforcement - inactives0.10.30.5-0.70.40.60.4-0.50.5-0.50.5
Conditioned locomotion1.62.46.11.3-2.0-0.4-2.5-1.31.3-1.31.3
Patch foraging indifference point 0 sec1.23.37.42.4-2.7-2.2-2.11.0-1.01.0-1.0
Patch foraging indifference point AUC0.51.11.70.60.0-0.90.81.3-1.31.3-1.3
Delay disc. indifference point, 0s delay1.01.11.81.3-1.2-1.3-0.70.9-0.90.9-0.9
Delay disc. indifference point, 16s delay0.10.10.2-0.40.30.40.0-0.20.2-0.20.2
Delay disc. indifference point, 2s delay1.21.41.81.2-0.8-1.30.01.4-1.41.4-1.4
Delay disc. indifference point, 24s delay0.50.71.5-1.21.21.10.7-0.50.5-0.50.5
Delay disc. indifference point, 4s delay2.02.22.91.4-0.9-1.70.11.7-1.71.7-1.7
Delay disc. indifference point, 8s delay0.10.10.2-0.10.1-0.10.10.4-0.40.4-0.4
Indifference point function ln k0.61.85.10.7-1.5-0.0-2.3-1.31.3-1.31.3
Indifference point function log k0.61.85.10.7-1.5-0.0-2.3-1.31.3-1.31.3
Patch foraging total patch changes 0 sec1.02.96.12.3-2.5-2.1-1.81.0-1.01.0-1.0
Patch foraging total patch changes 12 sec1.82.43.21.5-1.0-1.8-0.11.8-1.81.8-1.8
Patch foraging total patch changes 18 sec1.22.94.82.2-1.9-2.1-0.81.6-1.61.6-1.6
Patch foraging total patch changes 24 sec0.51.72.91.3-1.0-1.70.11.4-1.41.4-1.4
Patch foraging total patch changes 6 sec0.30.61.21.1-1.1-0.9-1.00.3-0.30.3-0.3
Patch foraging time to switch 0 sec1.03.86.4-2.52.52.41.6-1.51.5-1.51.5
Patch foraging water rate 0 sec0.72.76.32.3-2.5-2.0-2.00.8-0.80.8-0.8
Patch foraging water rate 12 sec0.31.44.11.5-2.0-1.1-1.8-0.20.2-0.20.2
Patch foraging water rate 18 sec0.41.02.01.4-1.4-1.4-0.80.5-0.50.5-0.5
Patch foraging water rate 24 sec0.91.33.90.7-1.4-0.2-2.0-1.01.0-1.01.0
Patch foraging water rate 6 sec0.50.81.90.9-1.4-0.6-1.4-0.60.6-0.60.6
Seeking ratio, delayed vs. immediate footshock1.31.82.8-1.71.31.60.8-1.31.3-1.31.3
Distance traveled before self-admin0.20.51.4-1.11.20.81.0-0.10.1-0.10.1
Distance traveled after self-admin1.52.74.1-1.20.61.7-0.7-2.02.0-2.02.0
Extensor digitorum longus weight0.52.13.20.00.7-0.71.71.8-1.81.8-1.8
Bone: elastic displacement2.02.54.1-2.01.72.00.7-1.51.5-1.51.5
Bone: elastic work2.22.94.7-2.11.72.20.6-1.71.7-1.71.7
Bone: endosteal estimation1.84.46.32.3-1.5-2.5-0.02.3-2.32.3-2.3
Bone: endosteal perimeter1.94.67.12.5-1.8-2.7-0.32.2-2.22.2-2.2
Epididymis fat weight0.10.72.0-0.91.20.51.40.5-0.50.5-0.5
Delta time in closed arm before/after self-admin2.22.15.5-0.81.50.02.31.4-1.41.4-1.4
Delta time in open arm before/after self-admin1.51.83.61.9-1.8-1.7-0.91.0-1.01.0-1.0
Diff in mean of infusions in LGA sessions2.13.87.5-2.72.72.32.2-1.21.2-1.21.2
Delay discount exponential model param0.10.20.30.1-0.20.1-0.3-0.50.5-0.50.5
Extinction: sum of active levers before priming0.10.20.30.2-0.1-0.30.30.6-0.60.6-0.6
Active lever presses in extinction session 62.82.88.40.5-1.50.5-2.9-1.71.7-1.71.7
Bone: final force0.00.10.2-0.40.40.30.3-0.10.1-0.10.1
Bone: final moment0.00.00.0-0.20.20.10.20.0-0.00.0-0.0
Food consumed during 24 hour testing period1.12.25.92.0-2.4-1.4-2.4-0.10.1-0.10.1
Glucose0.00.00.0-0.10.20.00.10.0-0.00.0-0.0
Heart weight0.40.61.71.1-1.3-0.9-1.00.2-0.20.2-0.2
Delay discount hyperbolic model param0.30.40.6-0.2-0.10.4-0.4-0.80.8-0.80.8
Intermittent access intake day 1-15 change0.10.51.70.6-0.9-0.3-1.3-0.60.6-0.60.6
Intermittent access intake escalation0.10.72.10.7-1.1-0.4-1.4-0.60.6-0.60.6
Intermittent access intake escalation 20.30.41.30.8-1.0-0.7-1.1-0.10.1-0.10.1
Intermitt. access day 1 inactive lever presses0.10.82.0-1.11.40.81.4-0.20.2-0.20.2
Intermitt. access day 15 inactive lever presses0.21.21.7-1.00.81.30.0-1.21.2-1.21.2
Intermitt. access escalation Index0.00.00.10.2-0.2-0.2-0.30.1-0.10.1-0.1
Intermittent access day 1 total infusions0.30.82.61.3-1.6-1.0-1.00.0-0.00.0-0.0
Intermittent access day 15 total infusions0.41.12.91.2-1.7-0.8-1.6-0.40.4-0.40.4
Intermittent access terminal intake (last 3 days)0.81.33.71.6-1.9-1.2-1.7-0.00.0-0.00.0
Intermittent access total infusions0.91.13.11.6-1.8-1.3-1.10.3-0.30.3-0.3
Intermittent access day 1 locomotion0.20.30.40.3-0.60.0-0.6-0.60.6-0.60.6
Intermittent access day 15 total locomotion0.31.12.70.6-1.3-0.1-1.6-1.01.0-1.01.0
Intermittent access total locomotion0.40.41.40.8-1.2-0.4-1.0-0.30.3-0.30.3
Intermittent access standard deviation0.10.60.90.9-0.3-0.80.00.9-0.90.9-0.9
Left kidney weight0.43.45.61.0-0.4-1.70.92.4-2.42.4-2.4
Right kidney weight0.74.87.51.4-0.6-2.31.12.7-2.72.7-2.7
Cocaine induced anxiety0.51.33.2-1.81.61.51.0-0.50.5-0.50.5
Post-drug Anxiety1.21.43.4-1.81.81.41.4-0.50.5-0.50.5
Baseline Anxiety0.10.20.50.6-0.5-0.70.00.3-0.30.3-0.3
Tail length1.47.411.21.9-0.8-2.91.33.4-3.43.4-3.4
Length with tail1.25.18.01.4-0.7-2.31.12.8-2.82.8-2.8
Length without tail0.00.20.4-0.50.50.20.60.3-0.30.3-0.3
Times rat made contact with spout0.60.71.4-0.20.7-0.21.20.9-0.90.9-0.9
Lifetime Intake1.01.33.81.7-2.0-1.4-1.10.3-0.30.3-0.3
Liver weight, left0.81.42.20.30.4-0.81.31.5-1.51.5-1.5
Liver weight, right1.42.45.3-0.41.3-0.52.31.7-1.71.7-1.7
Locomotor activity0.30.51.40.8-1.0-0.6-1.20.1-0.10.1-0.1
Locomotor testing distance0.82.03.71.9-1.7-1.8-1.11.2-1.21.2-1.2
Locomotor testing rearing0.52.03.01.1-0.7-1.50.11.7-1.71.7-1.7
Locomotion in novel chamber0.81.13.30.7-0.90.0-1.8-1.01.0-1.01.0
Locomotion in novel chamber post-restriction0.41.33.51.4-1.9-1.0-1.9-0.20.2-0.20.2
Fecal boli incidents, locomotor time 10.30.82.20.5-1.0-0.0-1.5-0.80.8-0.80.8
Change in fecal boli incidents, locomotor task0.30.30.9-0.70.90.51.0-0.20.2-0.20.2
Time >=10cm from walls, locomotor time 10.91.13.11.3-1.7-0.8-1.8-0.20.2-0.20.2
Bouts of movement, locomotor time 10.10.10.30.5-0.5-0.3-0.6-0.00.0-0.00.0
Total resting periods, locomotor time 10.30.40.70.2-0.40.2-0.8-0.70.7-0.70.7
Rest time, locomotor task time 10.50.81.3-0.50.10.8-0.5-1.21.2-1.21.2
Distance moved, locomotor task time 10.41.22.00.7-0.0-0.90.71.4-1.41.4-1.4
Vertical activity count, locomotor time 10.21.21.80.7-0.4-1.10.31.4-1.41.4-1.4
Time >=10cm from walls, locomotor time 20.41.32.61.6-1.5-1.4-0.80.8-0.80.8-0.8
Bouts of movement, locomotor time 20.41.21.61.2-0.5-1.20.31.3-1.31.3-1.3
Total resting periods, locomotor time 20.20.81.10.8-0.1-0.90.51.1-1.11.1-1.1
Rest time, locomotor task time 21.42.44.9-2.22.01.91.6-1.01.0-1.01.0
Distance moved, locomotor task time 22.23.05.02.2-2.0-2.1-1.21.5-1.51.5-1.5
Vertical activity count, locomotor time 20.81.92.51.4-1.2-1.6-0.31.5-1.51.5-1.5
Light reinforcement 10.52.15.2-2.22.31.71.90.0-0.00.0-0.0
Light reinforcement 20.20.40.9-0.80.50.90.1-0.50.5-0.50.5
Bone: marrow area1.64.05.62.1-1.3-2.40.12.3-2.32.3-2.3
Bone: maximum diameter1.63.24.82.1-1.6-2.2-0.51.8-1.81.8-1.8
Bone: maximum force0.00.00.1-0.20.20.20.10.0-0.00.0-0.0
Bone: maximum moment0.00.00.00.0-0.0-0.10.00.1-0.10.1-0.1
Mean time between licks in bursts1.37.811.02.9-2.1-3.3-0.13.1-3.13.1-3.1
Mean num. licks in bursts0.92.46.42.2-2.5-1.7-2.30.1-0.10.1-0.1
Cd content in liver0.50.51.2-0.40.7-0.11.10.8-0.80.8-0.8
Co content in liver1.51.82.71.5-1.2-1.6-0.31.4-1.41.4-1.4
Cu content in liver2.22.64.11.0-0.4-1.60.82.0-2.02.0-2.0
Fe content in liver0.00.00.1-0.30.20.20.20.0-0.00.0-0.0
K content in liver0.30.30.6-0.10.4-0.20.80.6-0.60.6-0.6
Mg content in liver0.10.10.20.4-0.3-0.4-0.10.3-0.30.3-0.3
Mn content in liver1.82.02.7-1.41.01.7-0.0-1.61.6-1.61.6
Na content in liver0.20.30.70.8-0.8-0.6-0.60.2-0.20.2-0.2
Rb content in liver0.20.20.50.7-0.7-0.6-0.40.3-0.30.3-0.3
Se content in liver3.64.38.0-2.82.52.61.4-1.71.7-1.71.7
Sr content in liver0.30.20.40.1-0.40.1-0.6-0.60.6-0.60.6
Zn content in liver2.53.04.72.2-1.9-2.2-0.81.6-1.61.6-1.6
Bone: minimum diameter1.93.65.51.3-0.4-1.91.02.3-2.32.3-2.3
Time in familiar zone, hab. session 10.20.20.40.10.1-0.40.50.6-0.60.6-0.6
Time in novel zone, hab. session 10.10.10.3-0.50.60.50.4-0.20.2-0.20.2
Total zone transitions, hab. session 10.40.61.0-0.3-0.10.6-0.7-1.01.0-1.01.0
Total locomotion distance, hab. session 11.11.53.2-0.41.1-0.31.81.4-1.41.4-1.4
Locomotion velocity, hab. session 10.60.91.8-0.30.8-0.31.31.1-1.11.1-1.1
Time in familiar zone, hab. session 21.21.42.31.5-1.4-1.5-0.71.0-1.01.0-1.0
Time in novel zone, hab. session 20.50.60.9-0.80.71.00.1-0.80.8-0.80.8
Total zone transitions, hab. session 20.81.03.01.0-1.5-0.5-1.7-0.60.6-0.60.6
Total locomotion distance, hab. session 21.21.62.50.50.1-1.01.01.6-1.61.6-1.6
Locomotion velocity, hab. session 21.41.93.10.40.3-1.01.31.8-1.81.8-1.8
Novel to familiar place preference ratio0.00.00.10.2-0.3-0.1-0.2-0.10.1-0.10.1
Novelty place preference0.00.00.10.2-0.3-0.1-0.2-0.10.1-0.10.1
Time in novel zone, NPP test0.10.10.20.4-0.5-0.3-0.5-0.00.0-0.00.0
Total zone transitions, NPP test0.20.40.90.2-0.50.2-0.9-0.60.6-0.60.6
Total locomotion distance, NPP test0.81.11.9-0.20.8-0.31.41.2-1.21.2-1.2
Locomotion velocity, NPP test0.81.12.6-0.51.1-0.11.61.1-1.11.1-1.1
Intraocular pressure0.40.61.20.1-0.40.3-1.1-0.90.9-0.90.9
Delta distance traveled before/after self-admin1.41.53.90.9-1.5-0.2-2.0-1.11.1-1.11.1
Delta ambulatory time before/after self-admin0.91.64.00.9-1.5-0.2-2.0-1.21.2-1.21.2
Parametrial fat weight0.40.92.6-1.21.40.71.60.3-0.30.3-0.3
Pavlov. Cond. lever latency1.01.32.7-1.61.51.41.0-0.80.8-0.80.8
Pavlov. Cond. magazine entry latency2.43.05.82.4-2.3-2.2-1.41.2-1.21.2-1.2
Pavlov. Cond. change in total contacts1.11.12.21.5-1.4-1.3-0.80.8-0.80.8-0.8
Pavlov. Cond. index score2.12.75.22.3-2.1-2.1-1.31.2-1.21.2-1.2
Pavlov. Cond. latency score2.02.54.92.2-2.1-2.0-1.31.1-1.11.1-1.1
Pavlov. Cond. lever contacts1.11.32.51.6-1.4-1.4-0.80.9-0.90.9-0.9
Pavlov. Cond. magazine entry number2.33.05.9-2.42.32.21.5-1.21.2-1.21.2
Pavlov. Cond. intertrial magazine entries0.81.01.7-1.31.21.20.7-0.80.8-0.80.8
Pavlov. Cond. lever-magazine prob. diff.1.72.14.12.0-1.9-1.8-1.11.0-1.01.0-1.0
Pavlov. Cond. response bias1.11.42.81.7-1.6-1.5-0.90.9-0.90.9-0.9
Pavlov. Cond. lever latency11.015.533.3-5.85.65.03.8-2.22.2-2.22.2
Pavlov. Cond. magazine entry latency1.92.76.92.4-2.6-1.8-2.20.3-0.30.3-0.3
Pavlov. Cond. change in total contacts4.611.224.24.9-4.9-4.2-3.51.7-1.71.7-1.7
Pavlov. Cond. index score7.011.023.64.9-4.8-4.2-3.41.7-1.71.7-1.7
Pavlov. Cond. latency score5.89.320.54.5-4.5-3.9-3.21.4-1.41.4-1.4
Pavlov. Cond. lever contacts10.115.031.75.6-5.5-4.9-3.72.2-2.22.2-2.2
Pavlov. Cond. magazine entry number3.64.712.0-3.23.52.52.9-0.50.5-0.50.5
Pavlov. Cond. intertrial magazine entries0.81.82.90.60.0-1.11.11.7-1.71.7-1.7
Pavlov. Cond. lever-magazine prob. diff.6.810.522.34.7-4.6-4.1-3.11.8-1.81.8-1.8
Pavlov. Cond. response bias10.614.731.65.6-5.6-4.8-3.92.0-2.02.0-2.0
Time in closed arm before self-admin1.22.16.10.8-1.6-0.2-2.5-1.31.3-1.31.3
Time in closed arm after self-admin1.31.41.8-1.20.91.3-0.0-1.41.4-1.41.4
Time in open arm before self-admin1.51.95.0-1.92.21.42.00.1-0.10.1-0.1
Time in open arm after self-admin1.11.32.10.7-0.1-0.90.71.4-1.41.4-1.4
Bone: periosteal estimation1.33.24.51.9-1.2-2.10.02.0-2.02.0-2.0
Bone: periosteal perimeter1.42.74.01.8-1.3-2.0-0.11.8-1.81.8-1.8
Bone: post-yield work0.10.10.10.3-0.2-0.3-0.00.4-0.40.4-0.4
Progressive ratio test 1 active lever presses0.20.30.5-0.3-0.10.5-0.2-0.70.7-0.70.7
Progressive ratio test 1 breakpoint0.10.30.4-0.3-0.00.4-0.1-0.70.7-0.70.7
Progressive ratio test 1 inactive lever presses0.10.20.3-0.50.00.50.2-0.50.5-0.50.5
Progressive ratio test 2 active lever presses0.30.40.70.8-0.8-0.8-0.40.6-0.60.6-0.6
Progressive ratio test 2 breakpoint0.30.40.70.8-0.9-0.8-0.40.5-0.50.5-0.5
Progressive ratio test 2 inactive lever presses0.10.20.50.3-0.7-0.1-0.6-0.30.3-0.30.3
Incentive Sensitization - Responses0.41.01.51.1-1.1-1.2-0.61.0-1.01.0-1.0
Incentive Sensitization - Breakpoint0.40.81.21.0-1.0-1.1-0.70.8-0.80.8-0.8
Sum of active levers in priming session hrs 5-60.10.10.2-0.30.10.5-0.2-0.20.2-0.20.2
Progressive ratio0.10.20.80.4-0.7-0.1-0.9-0.30.3-0.30.3
Food seeking constrained by brief footshock1.62.02.81.5-1.1-1.7-0.31.5-1.51.5-1.5
Seeking ratio, punishment vs. effort0.92.13.11.1-0.4-1.50.71.8-1.81.8-1.8
Retroperitoneal fat weight1.87.920.9-1.83.20.24.62.7-2.72.7-2.7
Reaction time number correct0.41.52.2-0.4-0.30.9-1.4-1.51.5-1.51.5
Reaction time mean minus median0.21.11.51.1-1.0-1.2-0.41.1-1.11.1-1.1
Reaction time mean minus median AUC0.10.81.81.2-1.4-1.0-1.10.5-0.50.5-0.5
Reaction time num false alarms0.81.33.4-1.51.90.91.80.4-0.40.4-0.4
Reaction time num false alarms AUC0.30.61.7-1.11.30.71.20.2-0.20.2-0.2
Reaction time trials correct on left0.41.52.2-0.4-0.30.9-1.4-1.51.5-1.51.5
Reaction time trials on left0.41.52.2-0.4-0.30.9-1.4-1.51.5-1.51.5
Reaction time mean0.30.71.9-0.91.10.41.40.6-0.60.6-0.6
Reaction time mean AUC0.30.81.9-1.31.30.81.40.2-0.20.2-0.2
Median of all reaction times0.71.02.6-1.51.60.91.60.2-0.20.2-0.2
Reaction time omissions0.40.61.1-0.10.4-0.20.81.0-1.01.0-1.0
Reaction time false alarm rate0.81.13.5-1.01.50.41.90.8-0.80.8-0.8
Reaction time premature initiation rate3.14.97.02.0-1.1-2.30.62.6-2.62.6-2.6
Reaction time premature initiations0.72.02.81.6-1.2-1.7-0.41.5-1.51.5-1.5
Std. dev. reaction times0.51.72.70.8-0.2-1.20.71.7-1.71.7-1.7
Reaction time trials completed0.41.52.2-0.4-0.30.9-1.4-1.51.5-1.51.5
Reaction time trials AUC0.31.01.7-0.3-0.30.7-1.3-1.21.2-1.21.2
Run reversals in cocaine runway, females3.03.35.30.10.8-1.02.32.2-2.22.2-2.2
Run reversals in cocaine runway, males0.10.10.2-0.40.30.40.2-0.40.4-0.40.4
Latency to leave start box in cocaine runway1.72.37.2-1.82.31.02.70.6-0.60.6-0.6
Latency to leave start box in cocaine runway, F2.53.19.3-1.52.30.53.01.4-1.41.4-1.4
Latency to leave start box in cocaine runway, M0.50.50.7-0.80.60.80.2-0.70.7-0.70.7
Std. dev. time between licks in bursts2.34.36.51.7-0.8-2.20.72.6-2.62.6-2.6
Total sessions with >9 infusions1.31.64.21.9-2.1-1.7-0.90.5-0.50.5-0.5
Short access day 1 total inactive lever presses0.00.00.2-0.1-0.2-0.10.4-0.20.2-0.20.2
Short access day 10 total inactive lever presses0.10.81.1-1.10.91.00.3-0.90.9-0.90.9
Short access day 1 total infusions1.63.26.02.4-2.4-2.4-1.01.4-1.41.4-1.4
Short access day 10 total infusions0.91.43.31.8-1.8-1.6-0.80.6-0.60.6-0.6
Short access total infusions1.21.74.51.9-2.1-1.6-1.00.7-0.70.7-0.7
Short access day 1 locomotion0.81.34.01.5-2.0-1.0-1.7-0.00.0-0.00.0
Short access day 10 total locomotion0.31.02.31.5-1.5-1.3-1.20.4-0.40.4-0.4
Short access total locomotion0.20.31.00.7-1.0-0.4-0.9-0.20.2-0.20.2
One hour access (0.3 mA shock)0.70.82.21.3-1.5-1.0-1.3-0.00.0-0.00.0
Compulsive drug intake1.62.33.2-1.50.81.8-0.8-1.71.7-1.71.7
One hour access (shock baseline)0.61.63.91.9-2.0-1.6-1.30.4-0.40.4-0.4
Social response proportion0.20.31.2-0.30.70.01.10.3-0.30.3-0.3
Social responses0.91.22.7-0.10.7-0.51.61.2-1.21.2-1.2
Social time1.62.54.4-2.11.92.11.1-1.31.3-1.31.3
Soleus weight1.44.26.60.20.8-1.22.32.6-2.62.6-2.6
Bone: stiffness0.20.41.2-0.71.00.41.10.4-0.40.4-0.4
Tibialis anterior weight0.31.21.90.5-0.1-1.00.81.4-1.41.4-1.4
Time to tail flick, vehicle, before self-admin0.20.20.50.5-0.5-0.2-0.7-0.40.4-0.40.4
Time to tail flick, vehicle, after self-admin0.40.82.31.3-1.5-1.0-1.00.1-0.10.1-0.1
Time to tail flick, test, before self-admin1.11.21.71.1-0.6-1.20.41.3-1.31.3-1.3
Time to tail flick, test, after self-admin1.01.11.50.8-0.3-1.10.51.2-1.21.2-1.2
Delta time to tail flick, vehicle, before/after SA0.30.30.90.8-0.9-0.8-0.30.4-0.40.4-0.4
Delta time to tail flick, test, before/after SA0.30.30.6-0.80.70.60.3-0.50.5-0.50.5
Tibia length0.92.57.81.8-2.4-0.9-2.8-0.80.8-0.80.8
Ambulatory time before self-admin0.30.91.7-1.31.21.20.6-0.80.8-0.80.8
Ambulatory time after self-admin2.03.25.3-0.7-0.11.4-1.4-2.32.3-2.32.3
Bone: tissue strength2.12.23.3-1.20.51.5-0.6-1.81.8-1.81.8
Total heroin consumption0.00.00.1-0.1-0.10.2-0.3-0.00.0-0.00.0
Bone: trabecular number1.01.92.9-1.71.31.70.3-1.41.4-1.41.4
Bone: trabecular spacing0.40.61.61.1-1.3-0.8-1.00.2-0.20.2-0.2
Bone: trabecular thickness0.20.30.9-0.80.90.60.8-0.00.0-0.00.0
Bone: trabecular tissue density0.91.64.4-1.11.70.42.11.0-1.01.0-1.0
Water consumed over 24 hours0.20.40.7-0.80.70.80.3-0.50.5-0.50.5
Number of responses in last shaping day0.60.81.7-0.10.6-0.31.31.0-1.01.0-1.0