Ppme1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	PL	mRNA stability	Ppme1	0.07	0.05	4.3e-06	0.05	0.04	0.05	0.04	3.7e-06	1.7e-05	6.7e-06	1.4e-05
2	Brain	mRNA stability	Ppme1	0.29	0.15	0.0e+00	0.21	0.24	0.24	0.24	4.8e-19	1.5e-22	4.2e-22	2.8e-22
3	Liver	gene expression	Ppme1	0.03	0.03	8.2e-04	0.02	0.01	0.01	0.01	2.5e-03	3.0e-02	1.3e-02	2.4e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3
Bone: apparent density	0.1	0.1	0.2	-0.4	0.1	-0.4
Area under the delay curve	0.1	0.1	0.1	-0.1	0.3	0.3
BMI with tail	0.1	0.2	0.5	0.0	0.2	0.7
BMI without tail	0.5	1.1	1.6	1.3	-0.2	1.2
Body weight	0.4	1.5	3.0	1.2	0.0	1.7
Weight adjusted by age	0.4	0.4	1.0	1.0	-0.5	0.3
Bone surface	0.7	1.3	1.6	1.3	-1.2	-0.9
Bone volume	0.5	0.8	0.9	0.9	-1.0	-0.8
Breakpoint value in progressive ratio session	0.2	0.2	0.4	-0.6	0.4	-0.1
Number of licking bursts	5.6	6.6	7.9	-2.3	2.8	2.6
Context. condit. distance diff. score	2.8	3.4	4.0	1.5	-2.0	-2.0
Locomotion velocity, session 1	0.2	0.2	0.4	-0.7	0.2	-0.4
Locomotion distance, session 1	1.0	1.3	1.8	0.8	-1.2	-1.4
Locomotion velocity, session 2	0.0	0.1	0.1	0.3	-0.3	-0.1
Locomotion distance, session 2	0.5	0.7	0.9	0.7	-0.9	-0.9
Locomotion velocity, session 3	0.9	1.1	1.9	0.6	-1.0	-1.4
Locomotion distance, session 3	1.7	1.9	3.2	0.8	-1.3	-1.8
Stereotopy head waving bouts, day 3	0.5	0.6	1.1	-0.4	0.7	1.0
Stereotopy head waving duration, day 3	0.1	0.1	0.2	0.1	-0.3	-0.4
Locomotion velocity, session 7	0.2	0.2	0.4	-0.6	0.5	0.1
Locomotion distance, session 7	0.1	0.2	0.2	-0.4	0.5	0.4
Stereotopy head waving bouts, day 7	2.9	3.3	3.8	1.6	-1.9	-1.9
Stereotopy head waving duration, day 7	3.4	4.1	4.8	2.0	-2.2	-1.9
Locomotion velocity, session 8	0.8	1.0	1.2	0.9	-1.1	-1.0
Locomotion distance, session 8	2.6	3.8	4.5	1.8	-2.1	-1.9
Degree of sensitization distance	1.6	1.6	3.7	-0.2	1.0	1.9
Degree of sensitization stereotypy	6.4	7.0	8.1	2.4	-2.8	-2.7
Conditioned locomotion	0.1	0.1	0.1	-0.4	0.2	-0.2
Cocaine response after cond. corrected	2.4	2.7	3.6	-1.3	1.7	1.9
Cocaine response after cond. not corrected	0.7	0.8	1.0	-0.7	0.9	1.0
Cocaine response before conditioning	2.3	2.8	3.9	1.2	-1.7	-2.0
Saline control response	1.8	2.3	3.8	1.9	-1.6	-0.7
Bone: connectivity density	0.2	0.3	0.7	-0.1	-0.3	-0.8
Bone: cortical apparent density	2.3	3.0	3.6	-1.5	1.8	1.9
Bone: cortical area	0.3	0.4	0.7	0.9	-0.6	-0.1
Bone: cortical porosity	1.2	1.4	2.1	0.7	-1.2	-1.5
Bone: cortical porosity	1.1	1.2	2.0	0.6	-1.1	-1.4
Bone: cortical thickness	0.1	0.2	0.3	-0.6	0.4	0.2
Bone: cortical thickness	0.2	0.2	0.5	0.2	-0.5	-0.7
Bone: cortical tissue density	2.3	3.0	3.5	-1.5	1.8	1.9
Condit. Reinf. active minus inactive responses	0.2	0.2	0.4	0.6	-0.3	0.3
Condit. Reinf. active-inactive response ratio	0.4	0.5	1.0	1.0	-0.6	0.2
Condit. Reinf. active responses	0.0	0.0	0.1	0.2	0.0	0.3
Condit. Reinf. inactive responses	0.0	0.0	0.1	-0.3	0.2	-0.0
Incentive salience index mean	0.2	0.2	0.5	0.7	-0.4	0.1
Condit. Reinf. lever presses	0.1	0.1	0.2	0.5	-0.3	-0.1
Condit. Reinf. active minus inactive responses	6.9	8.5	13.1	3.6	-3.1	-1.7
Condit. Reinf. active-inactive response ratio	1.8	1.9	2.5	1.6	-1.5	-1.0
Condit. Reinf. active responses	8.5	11.8	19.0	4.4	-3.6	-1.8
Condit. Reinf. inactive responses	4.6	5.7	9.8	3.1	-2.5	-1.0
Condit. Reinf. lever presses	17.8	24.1	31.9	5.6	-5.3	-3.5
Condit. Reinf. lever reinforcers received	9.8	13.8	21.2	4.6	-4.0	-2.1
Conditioned reinforcement - actives	3.5	3.5	4.0	1.6	-2.0	-2.0
Conditioned reinforcement - inactives	0.3	0.3	0.8	-0.2	0.4	0.9
Conditioned locomotion	3.5	4.2	6.0	1.5	-2.1	-2.5
Patch foraging indifference point 0 sec	4.2	6.7	8.1	2.7	-2.8	-2.2
Patch foraging indifference point AUC	0.2	0.3	0.4	0.6	0.1	0.7
Delay disc. indifference point, 0s delay	0.7	0.7	1.1	1.0	-0.9	-0.5
Delay disc. indifference point, 16s delay	0.1	0.1	0.2	-0.4	0.2	-0.1
Delay disc. indifference point, 2s delay	0.5	0.6	1.3	1.1	-0.6	0.1
Delay disc. indifference point, 24s delay	0.9	0.9	1.2	-1.1	1.1	0.6
Delay disc. indifference point, 4s delay	0.5	0.6	1.3	1.1	-0.6	0.2
Delay disc. indifference point, 8s delay	0.0	0.0	0.0	-0.0	-0.0	-0.1
Indifference point function ln k	1.8	2.5	4.7	0.7	-1.5	-2.2
Indifference point function log k	1.8	2.5	4.7	0.7	-1.5	-2.2
Patch foraging total patch changes 0 sec	3.3	5.3	6.3	2.5	-2.5	-1.9
Patch foraging total patch changes 12 sec	1.0	1.3	2.8	1.7	-1.0	-0.2
Patch foraging total patch changes 18 sec	2.2	2.8	4.6	2.1	-1.7	-0.9
Patch foraging total patch changes 24 sec	0.8	1.0	2.0	1.4	-1.0	0.0
Patch foraging total patch changes 6 sec	0.7	1.0	1.1	1.0	-1.0	-1.0
Patch foraging time to switch 0 sec	3.4	5.2	6.6	-2.6	2.5	1.6
Patch foraging water rate 0 sec	3.2	5.1	6.3	2.3	-2.5	-2.0
Patch foraging water rate 12 sec	2.2	3.4	4.4	1.5	-2.1	-1.8
Patch foraging water rate 18 sec	1.1	1.4	2.0	1.3	-1.4	-0.7
Patch foraging water rate 24 sec	1.6	2.3	4.2	0.7	-1.5	-2.0
Patch foraging water rate 6 sec	1.3	1.9	2.4	1.0	-1.5	-1.5
Seeking ratio, delayed vs. immediate footshock	1.3	1.5	2.7	-1.6	1.1	0.7
Distance traveled before self-admin	1.4	1.4	2.0	-1.2	1.4	1.0
Distance traveled after self-admin	0.4	0.5	0.7	-0.8	0.3	-0.8
Extensor digitorum longus weight	0.2	0.9	2.2	0.1	0.7	1.5
Bone: elastic displacement	2.1	2.4	4.0	-2.0	1.6	0.7
Bone: elastic work	1.7	2.2	4.2	-2.0	1.5	0.5
Bone: endosteal estimation	1.0	2.1	4.4	2.1	-1.4	-0.0
Bone: endosteal perimeter	1.4	2.9	5.5	2.4	-1.7	-0.5
Epididymis fat weight	0.9	2.1	4.6	-0.3	1.2	2.2
Delta time in closed arm before/after self-admin	2.7	2.7	5.3	-0.5	1.6	2.3
Delta time in open arm before/after self-admin	3.9	3.7	4.6	2.1	-2.1	-1.5
Diff in mean of infusions in LGA sessions	3.7	4.1	4.9	-2.1	2.2	1.8
Delay discount exponential model param	0.1	0.1	0.1	0.2	-0.4	-0.4
Extinction: sum of active levers before priming	0.1	0.1	0.2	-0.2	0.3	0.4
Active lever presses in extinction session 6	3.9	3.8	7.4	0.9	-1.8	-2.7
Bone: final force	0.0	0.0	0.0	-0.2	0.1	0.2
Bone: final moment	0.0	0.0	0.0	0.1	-0.1	0.0
Food consumed during 24 hour testing period	4.4	5.3	6.1	2.1	-2.5	-2.4
Glucose	0.1	0.1	0.2	0.1	-0.2	-0.4
Heart weight	1.3	1.9	2.3	1.4	-1.5	-1.2
Delay discount hyperbolic model param	0.1	0.1	0.1	-0.1	-0.2	-0.4
Intermittent access intake day 1-15 change	0.9	0.8	1.0	0.8	-0.9	-1.0
Intermittent access intake escalation	1.1	1.1	1.4	0.8	-1.0	-1.2
Intermittent access intake escalation 2	0.2	0.2	0.2	0.5	-0.4	-0.3
Intermitt. access day 1 inactive lever presses	0.4	0.5	1.0	-0.3	0.6	1.0
Intermitt. access day 15 inactive lever presses	0.2	0.2	0.2	0.3	-0.5	-0.5
Intermitt. access escalation Index	0.4	0.4	0.6	0.4	-0.6	-0.7
Intermittent access day 1 total infusions	1.2	1.4	2.0	1.4	-1.4	-0.6
Intermittent access day 15 total infusions	2.0	2.2	2.8	1.5	-1.7	-1.4
Intermittent access terminal intake (last 3 days)	1.7	1.9	2.3	1.5	-1.5	-1.1
Intermittent access total infusions	1.2	1.4	2.0	1.4	-1.3	-0.6
Intermittent access day 1 locomotion	0.1	0.1	0.2	0.3	-0.4	-0.4
Intermittent access day 15 total locomotion	1.7	1.8	2.2	1.1	-1.4	-1.5
Intermittent access total locomotion	0.8	0.9	1.1	1.0	-1.0	-0.7
Intermittent access standard deviation	0.1	0.1	0.3	0.6	-0.2	0.1
Left kidney weight	0.6	1.7	3.8	2.0	-1.0	0.4
Right kidney weight	0.3	0.9	2.1	1.4	-0.7	0.4
Cocaine induced anxiety	2.3	2.7	3.4	-1.8	1.8	1.2
Post-drug Anxiety	1.3	1.4	1.5	-1.2	1.2	1.2
Baseline Anxiety	1.1	1.1	1.8	1.3	-1.1	-0.6
Tail length	1.4	4.2	9.2	3.0	-1.4	1.3
Length with tail	0.6	2.2	3.7	1.9	-0.5	1.7
Length without tail	0.2	0.4	0.5	-0.7	0.7	0.5
Times rat made contact with spout	0.6	0.6	1.4	-0.2	0.7	1.2
Lifetime Intake	1.5	1.7	2.3	1.5	-1.5	-0.8
Liver weight, left	1.0	1.7	3.6	-0.4	1.1	1.9
Liver weight, right	2.3	3.9	8.1	-0.6	1.8	2.8
Locomotor activity	0.7	1.1	1.4	0.9	-1.0	-1.2
Locomotor testing distance	1.8	3.1	4.0	2.0	-1.9	-1.3
Locomotor testing rearing	0.4	0.6	1.4	1.2	-0.7	0.1
Locomotion in novel chamber	1.4	1.8	4.0	0.6	-1.0	-2.0
Locomotion in novel chamber post-restriction	2.6	3.1	3.9	1.4	-1.9	-2.0
Fecal boli incidents, locomotor time 1	1.3	1.4	2.4	0.7	-1.2	-1.5
Change in fecal boli incidents, locomotor task	1.2	1.2	1.3	-1.0	1.2	1.1
Time >=10cm from walls, locomotor time 1	2.3	2.3	2.9	1.2	-1.6	-1.7
Bouts of movement, locomotor time 1	0.3	0.3	0.5	0.4	-0.5	-0.7
Total resting periods, locomotor time 1	0.3	0.3	0.8	0.0	-0.4	-0.9
Rest time, locomotor task time 1	0.2	0.2	0.3	-0.6	0.0	-0.4
Distance moved, locomotor task time 1	0.3	0.3	0.5	0.7	-0.0	0.6
Vertical activity count, locomotor time 1	0.3	0.3	0.5	0.7	-0.4	0.4
Time >=10cm from walls, locomotor time 2	1.5	1.6	2.3	1.5	-1.4	-0.8
Bouts of movement, locomotor time 2	0.4	0.5	1.1	1.1	-0.2	0.4
Total resting periods, locomotor time 2	0.3	0.3	0.4	0.6	0.1	0.7
Rest time, locomotor task time 2	3.6	4.1	5.6	-2.4	2.1	1.5
Distance moved, locomotor task time 2	3.2	3.7	5.5	2.3	-2.1	-1.2
Vertical activity count, locomotor time 2	1.0	1.1	2.1	1.5	-1.1	-0.1
Light reinforcement 1	2.7	4.9	5.8	-2.3	2.4	1.9
Light reinforcement 2	0.2	0.3	0.6	-0.8	0.6	-0.0
Bone: marrow area	0.8	1.7	3.6	1.9	-1.2	0.1
Bone: maximum diameter	1.4	2.6	4.4	2.1	-1.7	-0.7
Bone: maximum force	0.0	0.0	0.0	0.1	-0.2	-0.1
Bone: maximum moment	0.1	0.1	0.2	0.4	-0.4	-0.2
Mean time between licks in bursts	3.8	5.3	10.5	3.2	-2.3	-0.2
Mean num. licks in bursts	4.5	5.4	6.5	2.2	-2.6	-2.2
Cd content in liver	0.8	0.9	1.6	-0.5	0.9	1.2
Co content in liver	1.2	1.4	2.5	1.6	-1.2	-0.3
Cu content in liver	0.6	0.8	1.7	1.3	-0.8	0.2
Fe content in liver	0.0	0.1	0.1	-0.1	0.2	0.3
K content in liver	0.3	0.3	0.6	-0.3	0.5	0.8
Mg content in liver	0.1	0.1	0.2	0.4	-0.4	-0.1
Mn content in liver	1.2	1.3	2.6	-1.6	1.1	0.1
Na content in liver	0.3	0.3	0.4	0.5	-0.6	-0.5
Rb content in liver	0.7	0.9	1.2	1.1	-1.0	-0.6
Se content in liver	3.3	4.1	5.6	-2.4	2.2	1.4
Sr content in liver	0.1	0.1	0.3	-0.3	-0.1	-0.5
Zn content in liver	4.8	5.4	6.7	2.6	-2.5	-1.7
Bone: minimum diameter	0.5	0.9	1.5	1.2	-0.3	1.0
Time in familiar zone, hab. session 1	0.1	0.1	0.2	0.1	0.1	0.4
Time in novel zone, hab. session 1	0.3	0.3	0.3	-0.5	0.6	0.4
Total zone transitions, hab. session 1	0.2	0.2	0.5	-0.2	-0.2	-0.7
Total locomotion distance, hab. session 1	1.1	1.6	3.2	-0.5	1.2	1.8
Locomotion velocity, hab. session 1	0.6	0.9	1.8	-0.3	0.8	1.4
Time in familiar zone, hab. session 2	1.5	1.5	2.2	1.5	-1.4	-0.7
Time in novel zone, hab. session 2	0.3	0.3	0.6	-0.8	0.6	0.1
Total zone transitions, hab. session 2	1.7	2.2	3.0	1.1	-1.5	-1.7
Total locomotion distance, hab. session 2	0.3	0.5	1.1	0.5	0.2	1.1
Locomotion velocity, hab. session 2	0.5	0.7	1.8	0.4	0.4	1.3
Novel to familiar place preference ratio	0.1	0.1	0.1	0.2	-0.3	-0.3
Novelty place preference	0.1	0.1	0.1	0.2	-0.3	-0.3
Time in novel zone, NPP test	0.2	0.2	0.3	0.4	-0.5	-0.5
Total zone transitions, NPP test	0.3	0.5	0.9	0.3	-0.6	-1.0
Total locomotion distance, NPP test	0.7	0.9	2.0	-0.2	0.8	1.4
Locomotion velocity, NPP test	1.0	1.5	2.8	-0.5	1.2	1.7
Intraocular pressure	0.4	0.6	1.3	0.3	-0.6	-1.2
Delta distance traveled before/after self-admin	1.7	1.9	2.4	1.0	-1.5	-1.5
Delta ambulatory time before/after self-admin	1.9	2.1	3.1	1.0	-1.5	-1.8
Parametrial fat weight	1.3	2.6	4.4	-1.0	1.5	2.1
Pavlov. Cond. lever latency	1.3	1.6	2.2	-1.5	1.4	0.9
Pavlov. Cond. magazine entry latency	2.9	3.8	5.1	2.3	-2.1	-1.3
Pavlov. Cond. change in total contacts	1.4	1.5	2.1	1.5	-1.4	-0.8
Pavlov. Cond. index score	2.9	3.7	5.3	2.3	-2.1	-1.2
Pavlov. Cond. latency score	2.9	3.6	5.1	2.3	-2.1	-1.2
Pavlov. Cond. lever contacts	1.2	1.4	2.3	1.5	-1.3	-0.6
Pavlov. Cond. magazine entry number	3.5	4.4	5.5	-2.3	2.3	1.5
Pavlov. Cond. intertrial magazine entries	1.0	1.2	1.7	-1.3	1.2	0.7
Pavlov. Cond. lever-magazine prob. diff.	2.4	3.0	4.2	2.0	-1.9	-1.1
Pavlov. Cond. response bias	1.2	1.4	2.2	1.5	-1.3	-0.6
Pavlov. Cond. lever latency	18.4	24.8	31.2	-5.6	5.4	3.8
Pavlov. Cond. magazine entry latency	4.6	5.3	6.3	2.2	-2.5	-2.1
Pavlov. Cond. change in total contacts	14.6	20.1	23.5	4.9	-4.8	-3.7
Pavlov. Cond. index score	14.5	18.6	22.4	4.7	-4.7	-3.4
Pavlov. Cond. latency score	13.1	16.3	19.2	4.4	-4.4	-3.2
Pavlov. Cond. lever contacts	19.2	26.2	32.9	5.7	-5.5	-3.9
Pavlov. Cond. magazine entry number	8.2	10.0	11.7	-3.1	3.4	2.9
Pavlov. Cond. intertrial magazine entries	0.4	0.6	1.4	0.5	0.2	1.2
Pavlov. Cond. lever-magazine prob. diff.	13.5	17.1	21.2	4.6	-4.5	-3.2
Pavlov. Cond. response bias	19.6	26.7	32.3	5.7	-5.6	-4.1
Time in closed arm before self-admin	3.2	3.7	7.1	0.7	-1.8	-2.7
Time in closed arm after self-admin	0.7	0.7	1.5	-1.2	0.7	-0.2
Time in open arm before self-admin	5.0	5.4	6.8	-2.1	2.6	2.2
Time in open arm after self-admin	0.4	0.4	0.9	0.9	-0.2	0.6
Bone: periosteal estimation	0.9	1.8	3.5	1.9	-1.3	-0.1
Bone: periosteal perimeter	1.1	1.8	3.4	1.8	-1.4	-0.5
Bone: post-yield work	0.2	0.2	0.3	0.5	-0.5	-0.4
Progressive ratio test 1 active lever presses	0.1	0.1	0.2	-0.3	0.2	0.4
Progressive ratio test 1 breakpoint	0.1	0.1	0.3	-0.2	0.2	0.5
Progressive ratio test 1 inactive lever presses	0.3	0.3	0.5	0.7	-0.7	0.3
Progressive ratio test 2 active lever presses	0.9	1.0	1.7	1.3	-1.0	-0.5
Progressive ratio test 2 breakpoint	1.0	1.1	1.9	1.4	-1.1	-0.5
Progressive ratio test 2 inactive lever presses	1.0	1.1	1.5	1.1	-1.2	-0.8
Incentive Sensitization - Responses	2.2	2.2	3.5	1.9	-1.5	-0.9
Incentive Sensitization - Breakpoint	2.1	2.1	3.1	1.8	-1.5	-1.0
Sum of active levers in priming session hrs 5-6	0.1	0.1	0.2	-0.4	0.3	-0.4
Progressive ratio	0.1	0.1	0.3	0.0	-0.2	-0.5
Food seeking constrained by brief footshock	0.7	0.9	1.9	1.4	-0.8	-0.1
Seeking ratio, punishment vs. effort	0.5	0.6	1.4	1.2	-0.6	0.5
Retroperitoneal fat weight	4.7	15.5	30.7	-1.7	3.6	5.5
Reaction time number correct	0.6	0.8	2.0	-0.5	-0.4	-1.4
Reaction time mean minus median	0.5	0.7	1.2	1.1	-0.9	-0.3
Reaction time mean minus median AUC	1.1	1.4	1.7	1.1	-1.3	-1.1
Reaction time num false alarms	2.4	3.3	3.8	-1.6	1.9	1.9
Reaction time num false alarms AUC	1.2	1.7	1.9	-1.2	1.4	1.2
Reaction time trials correct on left	0.6	0.8	2.0	-0.5	-0.4	-1.4
Reaction time trials on left	0.6	0.8	2.0	-0.5	-0.3	-1.4
Reaction time mean	1.0	1.4	2.0	-0.8	1.2	1.4
Reaction time mean AUC	1.3	1.7	2.1	-1.2	1.3	1.4
Median of all reaction times	1.7	2.3	2.6	-1.3	1.6	1.6
Reaction time omissions	0.4	0.5	0.8	-0.5	0.8	0.9
Reaction time false alarm rate	1.7	2.4	3.6	-1.0	1.6	1.9
Reaction time premature initiation rate	1.2	1.6	3.6	1.9	-1.0	0.6
Reaction time premature initiations	0.9	1.3	2.3	1.5	-1.2	-0.4
Std. dev. reaction times	0.3	0.4	0.6	0.8	-0.1	0.8
Reaction time trials completed	0.6	0.8	2.0	-0.5	-0.3	-1.4
Reaction time trials AUC	0.4	0.6	1.6	-0.4	-0.3	-1.3
Run reversals in cocaine runway, females	2.5	2.5	6.5	0.2	1.0	2.5
Run reversals in cocaine runway, males	0.1	0.1	0.1	-0.3	0.2	0.2
Latency to leave start box in cocaine runway	3.7	4.0	5.4	-1.6	2.0	2.3
Latency to leave start box in cocaine runway, F	3.3	3.7	6.3	-1.1	1.8	2.5
Latency to leave start box in cocaine runway, M	0.4	0.3	0.8	-0.9	0.5	0.0
Std. dev. time between licks in bursts	1.1	1.3	3.0	1.7	-0.8	0.6
Total sessions with >9 infusions	2.8	3.1	4.4	1.6	-2.1	-1.5
Short access day 1 total inactive lever presses	0.1	0.1	0.2	-0.4	0.2	0.4
Short access day 10 total inactive lever presses	0.1	0.1	0.2	-0.4	0.3	-0.1
Short access day 1 total infusions	2.4	2.6	3.6	1.8	-1.9	-0.9
Short access day 10 total infusions	1.4	1.6	2.7	1.7	-1.3	-0.4
Short access total infusions	1.0	1.2	1.8	1.3	-1.3	-0.2
Short access day 1 locomotion	2.2	2.3	3.0	1.1	-1.7	-1.7
Short access day 10 total locomotion	0.3	0.4	0.6	0.8	-0.6	-0.4
Short access total locomotion	0.1	0.2	0.2	0.4	-0.5	-0.3
One hour access (0.3 mA shock)	2.4	2.8	3.8	2.0	-1.8	-1.2
Compulsive drug intake	0.2	0.2	0.3	-0.5	0.0	-0.6
One hour access (shock baseline)	1.9	2.2	3.4	1.8	-1.5	-0.9
Social response proportion	0.5	0.5	0.9	-0.4	0.6	1.0
Social responses	0.8	1.0	2.4	-0.1	0.7	1.5
Social time	2.8	3.6	5.7	-2.4	2.0	1.2
Soleus weight	0.6	1.6	4.2	0.4	0.7	2.0
Bone: stiffness	0.3	0.5	0.9	-0.3	0.6	1.0
Tibialis anterior weight	0.1	0.3	0.5	0.7	-0.2	0.5
Time to tail flick, vehicle, before self-admin	0.1	0.1	0.2	-0.2	0.1	-0.5
Time to tail flick, vehicle, after self-admin	2.8	3.0	3.9	1.5	-2.0	-1.7
Time to tail flick, test, before self-admin	0.4	0.4	0.8	0.9	-0.5	0.3
Time to tail flick, test, after self-admin	0.3	0.4	0.8	0.9	-0.3	0.4
Delta time to tail flick, vehicle, before/after SA	1.6	1.6	2.5	1.2	-1.6	-0.9
Delta time to tail flick, test, before/after SA	0.3	0.3	0.3	-0.5	0.6	0.4
Tibia length	2.1	6.0	8.1	1.8	-2.6	-2.8
Ambulatory time before self-admin	1.3	1.3	1.8	-1.2	1.3	0.8
Ambulatory time after self-admin	0.6	0.6	1.5	-0.6	-0.0	-1.2
Bone: tissue strength	0.5	0.5	0.7	-0.8	0.1	-0.9
Total heroin consumption	0.3	0.4	0.7	0.3	-0.7	-0.8
Bone: trabecular number	0.6	1.0	1.9	-1.4	1.0	0.1
Bone: trabecular spacing	0.8	1.1	1.4	1.0	-1.2	-0.9
Bone: trabecular thickness	0.3	0.3	0.4	-0.5	0.6	0.6
Bone: trabecular tissue density	2.0	2.8	5.1	-0.9	1.6	2.3
Water consumed over 24 hours	0.5	0.6	0.9	-0.9	0.9	0.3
Number of responses in last shaping day	0.2	0.2	0.6	0.7	-0.4	0.1