Hub : Genes

P2ry2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Liver gene expression P2ry2 0.04 0.03 9.7e-04 0.03 0.02 0.01 0.02 8.1e-04 1.6e-03 1.0e-02 1.3e-03
2 Adipose mRNA stability P2ry2 0.12 0.06 4.1e-12 0.09 0.09 0.09 0.09 6.2e-10 1.5e-10 1.1e-09 5.3e-10
3 Eye gene expression P2ry2 0.48 0.21 2.9e-03 0.04 0 -0.01 0.03 8.4e-02 2.7e-01 4.6e-01 9.9e-02
4 IC gene expression P2ry2 0.1 0.07 4.1e-03 0.03 0.05 0.05 0.05 2.9e-02 3.5e-03 4.6e-03 5.4e-03
5 pVTA gene expression P2ry2 0.13 0.08 1.9e-07 0.08 0.09 0.1 0.1 1.0e-06 7.4e-08 2.7e-08 4.9e-08
6 NAcc gene expression P2ry2 0.1 0.05 1.1e-10 0.07 0.07 0.06 0.08 2.3e-11 1.7e-11 5.5e-10 1.5e-11
7 Brain gene expression P2ry2 0.16 0.08 4.5e-13 0.16 0.13 0.15 0.15 7.5e-15 5.4e-12 7.9e-14 5.1e-14
8 BLA gene expression P2ry2 0.12 0.07 7.9e-05 0.04 0.07 0.06 0.06 2.6e-03 1.4e-04 6.8e-04 4.6e-04
9 Liver mRNA stability P2ry2 0.03 0.02 4.7e-03 0 0.01 0.01 0 1.2e-01 1.3e-02 2.2e-02 7.9e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9
Bone: apparent density0.30.60.90.6-0.8-0.6-0.9-0.8-0.9-0.8-0.5-0.6
Area under the delay curve0.10.10.50.7-0.10.10.00.30.20.10.40.4
BMI with tail0.62.14.50.60.60.41.20.92.12.12.01.7
BMI without tail1.34.08.0-1.31.81.42.21.62.82.61.91.9
Body weight1.46.110.0-1.11.91.42.52.83.22.82.82.8
Weight adjusted by age0.40.61.1-0.70.70.60.80.91.11.00.70.7
Bone surface0.30.61.2-1.11.01.00.90.70.50.7-0.3-0.2
Bone volume0.10.30.6-0.70.70.70.60.50.20.4-0.2-0.1
Breakpoint value in progressive ratio session1.01.22.20.9-1.4-1.5-1.4-1.1-1.4-0.9-0.5-0.5
Number of licking bursts1.32.25.22.3-2.0-1.6-1.4-0.1-0.1-0.21.81.6
Context. condit. distance diff. score1.31.65.5-2.41.31.40.8-0.4-0.3-0.2-1.6-1.4
Locomotion velocity, session 11.41.53.00.9-1.1-0.9-1.3-1.7-1.3-1.4-0.9-1.1
Locomotion distance, session 10.50.61.6-0.60.50.40.1-1.0-0.5-0.6-1.3-1.3
Locomotion velocity, session 20.10.10.2-0.20.30.50.3-0.40.30.1-0.0-0.1
Locomotion distance, session 20.20.30.8-0.30.50.90.3-0.7-0.0-0.0-0.7-0.6
Locomotion velocity, session 30.50.61.6-1.10.4-0.4-0.0-0.6-0.7-0.4-1.3-1.1
Locomotion distance, session 30.91.02.9-1.00.30.2-0.2-1.0-1.0-0.6-1.7-1.6
Stereotopy head waving bouts, day 30.40.51.40.10.1-0.20.30.90.60.61.11.2
Stereotopy head waving duration, day 30.10.10.3-0.60.30.00.1-0.2-0.2-0.2-0.4-0.4
Locomotion velocity, session 70.40.41.10.3-0.7-0.0-0.8-1.1-0.8-0.4-0.4-0.5
Locomotion distance, session 70.10.10.40.4-0.40.6-0.3-0.1-0.10.20.30.3
Stereotopy head waving bouts, day 71.41.65.4-2.31.50.80.9-0.1-0.2-0.3-1.7-1.4
Stereotopy head waving duration, day 71.31.65.3-2.31.80.91.20.10.30.1-1.4-1.2
Locomotion velocity, session 80.50.62.7-1.71.00.70.70.1-0.00.0-0.8-0.6
Locomotion distance, session 81.21.74.7-2.21.71.61.1-0.30.10.3-1.4-1.2
Degree of sensitization distance2.22.25.00.20.41.01.01.81.61.62.22.2
Degree of sensitization stereotypy2.52.89.3-3.12.11.31.40.10.10.0-2.0-1.8
Conditioned locomotion0.30.31.20.4-0.4-1.1-0.40.0-0.9-0.3-0.4-0.2
Cocaine response after cond. corrected0.81.02.11.5-1.0-1.2-0.50.30.40.21.51.3
Cocaine response after cond. not corrected0.30.31.11.1-0.7-0.8-0.5-0.30.1-0.10.60.3
Cocaine response before conditioning1.21.43.8-1.20.60.40.1-1.2-0.8-0.9-1.9-2.0
Saline control response1.62.24.0-1.92.01.71.81.61.11.3-0.00.3
Bone: connectivity density0.61.02.10.4-0.8-0.5-1.0-1.5-1.0-1.2-1.0-1.2
Bone: cortical apparent density0.81.12.11.4-1.2-1.3-0.70.40.10.21.41.3
Bone: cortical area0.40.61.2-0.50.80.30.91.00.81.10.60.7
Bone: cortical porosity0.50.51.7-0.20.1-0.4-0.3-0.5-0.9-0.4-1.3-1.2
Bone: cortical porosity0.50.51.8-0.30.2-0.3-0.2-0.4-0.8-0.4-1.4-1.3
Bone: cortical thickness0.30.51.61.0-0.8-1.2-0.8-0.6-0.6-0.50.10.0
Bone: cortical thickness0.00.00.1-0.30.30.00.20.1-0.2-0.1-0.3-0.2
Bone: cortical tissue density0.81.02.21.5-1.3-1.3-0.80.3-0.10.11.31.2
Condit. Reinf. active minus inactive responses0.80.91.8-0.90.90.81.01.31.01.00.70.9
Condit. Reinf. active-inactive response ratio1.51.62.8-1.21.21.41.41.71.31.30.70.9
Condit. Reinf. active responses0.30.40.9-0.20.50.30.61.00.50.60.60.7
Condit. Reinf. inactive responses0.10.20.70.8-0.3-0.5-0.3-0.3-0.3-0.4-0.1-0.1
Incentive salience index mean0.60.81.3-0.50.91.01.01.10.91.10.60.7
Condit. Reinf. lever presses0.10.20.80.10.50.90.50.10.40.4-0.00.0
Condit. Reinf. active minus inactive responses5.87.514.3-3.73.63.83.32.22.32.2-0.20.2
Condit. Reinf. active-inactive response ratio1.01.12.5-1.51.41.61.20.60.81.0-0.3-0.2
Condit. Reinf. active responses8.311.622.1-4.34.54.74.22.93.02.80.10.6
Condit. Reinf. inactive responses5.06.511.4-2.93.43.43.32.42.32.30.40.8
Condit. Reinf. lever presses10.915.132.2-5.25.55.74.82.42.92.9-1.1-0.6
Condit. Reinf. lever reinforcers received8.912.424.2-4.44.74.94.42.93.02.9-0.10.4
Conditioned reinforcement - actives0.40.72.1-0.60.70.50.3-0.5-0.5-0.6-1.4-1.4
Conditioned reinforcement - inactives0.10.20.70.8-0.5-0.6-0.40.0-0.3-0.6-0.00.0
Conditioned locomotion1.51.95.8-0.60.60.8-0.1-1.5-1.1-1.1-2.4-2.4
Patch foraging indifference point 0 sec1.01.84.4-1.82.11.61.70.70.70.6-1.1-0.9
Patch foraging indifference point AUC0.71.11.7-0.60.80.61.01.11.31.31.11.2
Delay disc. indifference point, 0s delay0.80.91.8-1.01.41.41.20.60.80.9-0.10.1
Delay disc. indifference point, 16s delay0.10.10.20.3-0.4-0.3-0.30.3-0.3-0.50.00.1
Delay disc. indifference point, 2s delay1.01.12.0-0.71.31.41.31.01.21.10.50.7
Delay disc. indifference point, 24s delay0.70.82.21.2-1.2-1.5-0.90.0-0.7-0.80.40.4
Delay disc. indifference point, 4s delay2.02.13.1-1.01.61.41.81.51.61.70.91.1
Delay disc. indifference point, 8s delay0.10.10.50.7-0.20.1-0.10.00.00.10.10.1
Indifference point function ln k0.91.64.4-0.60.10.1-0.4-1.2-1.4-1.6-2.1-2.0
Indifference point function log k0.91.64.4-0.60.10.1-0.4-1.2-1.4-1.6-2.1-2.0
Patch foraging total patch changes 0 sec0.91.63.9-1.62.01.61.60.70.80.7-0.9-0.7
Patch foraging total patch changes 12 sec1.82.33.8-1.31.61.11.81.71.72.01.01.1
Patch foraging total patch changes 18 sec1.21.83.4-1.41.81.81.71.11.41.3-0.00.1
Patch foraging total patch changes 24 sec1.42.43.4-1.41.61.61.81.71.71.80.91.0
Patch foraging total patch changes 6 sec0.20.31.0-1.00.90.50.70.30.40.6-0.3-0.2
Patch foraging time to switch 0 sec1.53.06.32.5-2.5-2.4-2.2-1.1-1.3-1.10.50.3
Patch foraging water rate 0 sec0.92.04.4-2.12.01.91.60.60.60.6-1.0-0.8
Patch foraging water rate 12 sec0.51.01.9-1.31.21.10.8-0.7-0.1-0.1-1.4-1.3
Patch foraging water rate 18 sec1.01.64.0-2.01.71.91.50.50.90.9-0.2-0.1
Patch foraging water rate 24 sec0.71.02.7-0.40.40.0-0.1-1.0-0.9-1.1-1.6-1.6
Patch foraging water rate 6 sec0.40.61.5-0.80.81.20.5-0.5-0.30.0-1.1-1.1
Seeking ratio, delayed vs. immediate footshock1.21.52.71.6-1.6-1.6-1.6-1.0-1.0-0.8-0.3-0.6
Distance traveled before self-admin0.30.40.90.7-0.9-0.7-0.7-0.3-0.30.00.70.6
Distance traveled after self-admin1.72.13.60.3-1.3-1.2-1.6-1.9-1.9-1.5-1.3-1.3
Extensor digitorum longus weight0.41.43.50.50.20.30.71.11.71.21.91.7
Bone: elastic displacement2.42.84.21.7-2.0-2.0-2.0-1.8-1.6-1.9-0.4-0.6
Bone: elastic work3.14.06.02.1-2.4-2.5-2.4-2.3-1.8-2.1-0.6-1.0
Bone: endosteal estimation2.04.46.0-1.92.32.42.42.42.32.41.11.2
Bone: endosteal perimeter2.24.76.7-2.12.52.52.62.22.32.50.81.0
Epididymis fat weight0.20.51.11.1-0.9-0.9-0.60.10.3-0.01.00.8
Delta time in closed arm before/after self-admin1.61.54.41.1-0.5-0.40.11.21.11.02.11.9
Delta time in open arm before/after self-admin2.01.94.5-2.12.01.81.71.01.00.9-0.5-0.2
Diff in mean of infusions in LGA sessions1.41.84.61.5-1.9-2.1-1.5-0.1-0.9-0.50.90.9
Delay discount exponential model param0.10.10.5-0.70.1-0.0-0.0-0.2-0.2-0.2-0.4-0.4
Extinction: sum of active levers before priming0.10.10.2-0.40.40.10.40.30.30.20.20.3
Active lever presses in extinction session 62.92.97.4-0.4-0.10.3-0.9-2.0-2.0-1.7-2.7-2.6
Bone: final force0.10.20.40.6-0.2-0.6-0.10.6-0.20.40.30.4
Bone: final moment0.10.10.40.4-0.0-0.30.10.7-0.10.60.20.4
Food consumed during 24 hour testing period1.31.83.8-1.91.71.81.1-0.30.0-0.0-1.7-1.6
Glucose0.00.00.3-0.0-0.1-0.5-0.1-0.30.00.20.0-0.1
Heart weight0.30.51.9-1.41.00.50.70.20.10.2-0.8-0.6
Delay discount hyperbolic model param0.20.20.4-0.6-0.1-0.3-0.3-0.4-0.5-0.4-0.6-0.6
Intermittent access intake day 1-15 change0.30.51.6-0.40.40.50.0-1.3-0.3-0.6-1.0-1.1
Intermittent access intake escalation0.30.61.6-0.60.50.50.1-1.3-0.4-0.6-1.2-1.2
Intermittent access intake escalation 20.20.20.5-0.20.60.70.4-0.30.30.2-0.4-0.5
Intermitt. access day 1 inactive lever presses0.20.72.51.6-0.9-0.7-0.60.20.1-0.01.00.9
Intermitt. access day 15 inactive lever presses0.51.01.80.5-1.1-1.0-1.2-1.2-1.3-1.2-0.7-0.6
Intermitt. access escalation Index0.10.10.6-0.10.20.50.20.30.20.70.00.1
Intermittent access day 1 total infusions0.60.92.2-1.51.21.10.80.3-0.1-0.1-1.2-1.0
Intermittent access day 15 total infusions0.60.92.3-1.11.10.80.6-0.5-0.4-0.5-1.5-1.4
Intermittent access terminal intake (last 3 days)0.81.02.2-1.51.41.20.9-0.0-0.10.0-1.3-1.1
Intermittent access total infusions0.91.12.4-1.61.51.41.20.20.30.2-1.0-0.8
Intermittent access day 1 locomotion0.30.41.2-0.30.20.2-0.1-0.2-0.7-0.7-1.1-0.9
Intermittent access day 15 total locomotion0.71.33.3-0.20.20.4-0.3-1.4-1.1-1.2-1.8-1.8
Intermittent access total locomotion0.50.61.6-0.80.70.70.3-0.4-0.5-0.7-1.2-1.1
Intermittent access standard deviation0.10.30.6-0.10.50.60.60.10.80.50.60.6
Left kidney weight0.62.74.8-0.71.31.11.71.82.22.01.81.8
Right kidney weight1.04.77.6-1.01.81.82.32.62.72.42.22.2
Cocaine induced anxiety1.21.75.02.2-1.8-1.7-1.5-0.5-0.9-0.90.40.3
Post-drug Anxiety0.91.02.61.2-1.4-1.6-1.10.2-0.5-0.70.80.8
Baseline Anxiety0.80.93.3-1.81.10.81.11.00.70.50.20.4
Tail length2.610.014.5-3.23.12.53.53.83.63.02.52.9
Length with tail1.87.813.1-2.92.82.23.13.62.92.62.22.6
Length without tail0.10.20.8-0.40.20.20.30.90.20.20.60.8
Times rat made contact with spout0.50.61.40.30.10.30.40.90.90.81.21.2
Lifetime Intake1.11.43.3-1.81.71.51.20.20.30.1-1.1-0.9
Liver weight, left1.01.62.80.50.40.70.91.71.51.41.71.6
Liver weight, right1.62.86.80.30.10.10.82.21.91.82.62.6
Locomotor activity0.20.30.8-0.90.70.50.5-0.0-0.10.1-0.5-0.4
Locomotor testing distance1.01.83.5-1.81.91.61.71.11.01.4-0.00.2
Locomotor testing rearing0.91.92.7-1.31.51.21.61.61.31.60.91.1
Locomotion in novel chamber0.81.02.11.0-0.50.0-0.7-1.2-1.0-1.0-1.3-1.5
Locomotion in novel chamber post-restriction0.61.02.3-1.11.11.30.6-0.5-0.2-0.0-1.5-1.5
Fecal boli incidents, locomotor time 10.60.92.01.4-0.30.6-0.5-1.0-0.6-0.6-1.2-1.4
Change in fecal boli incidents, locomotor task0.20.20.5-0.6-0.3-0.6-0.10.60.1-0.10.70.7
Time >=10cm from walls, locomotor time 10.60.61.5-0.80.90.90.50.2-0.3-0.1-1.2-1.1
Bouts of movement, locomotor time 10.10.10.2-0.20.40.40.30.30.00.2-0.3-0.2
Total resting periods, locomotor time 10.20.20.60.2-0.10.1-0.3-0.3-0.6-0.4-0.8-0.7
Rest time, locomotor task time 10.50.61.2-0.2-0.6-0.3-0.8-0.5-1.1-1.0-1.0-0.9
Distance moved, locomotor task time 10.60.92.00.00.60.20.90.81.21.41.21.1
Vertical activity count, locomotor time 10.30.81.5-0.10.90.71.00.91.11.20.80.8
Time >=10cm from walls, locomotor time 21.21.74.1-2.01.81.21.71.70.80.7-0.10.2
Bouts of movement, locomotor time 21.21.94.6-0.71.20.41.52.11.51.61.31.4
Total resting periods, locomotor time 20.71.33.2-0.20.70.11.01.81.21.31.21.3
Rest time, locomotor task time 21.31.63.71.7-1.9-1.6-1.7-1.0-0.9-1.00.40.2
Distance moved, locomotor task time 21.72.14.7-1.82.21.32.01.31.21.4-0.10.1
Vertical activity count, locomotor time 20.81.12.2-0.91.41.01.51.21.11.00.40.6
Light reinforcement 10.92.35.72.1-2.1-2.4-1.7-1.0-0.6-0.91.00.7
Light reinforcement 20.81.23.30.8-1.0-1.1-1.1-1.8-0.9-1.2-0.6-0.9
Bone: marrow area1.94.15.7-1.72.12.22.32.32.32.41.11.3
Bone: maximum diameter1.63.04.9-2.12.21.42.21.81.72.00.50.7
Bone: maximum force0.00.10.20.3-0.1-0.4-0.10.4-0.20.30.10.2
Bone: maximum moment0.00.10.20.00.1-0.20.10.40.00.50.10.1
Mean time between licks in bursts3.38.112.4-2.73.42.53.53.43.03.11.41.8
Mean num. licks in bursts1.32.04.5-2.12.01.71.40.40.30.4-1.5-1.2
Cd content in liver0.40.41.00.20.0-0.10.30.90.70.71.01.0
Co content in liver1.82.13.1-1.61.71.71.81.81.41.30.50.7
Cu content in liver2.12.43.7-0.81.41.41.71.91.91.81.31.4
Fe content in liver0.00.00.00.1-0.1-0.1-0.10.0-0.1-0.1-0.00.0
K content in liver0.30.30.70.60.10.10.30.50.60.50.80.8
Mg content in liver0.00.00.10.10.30.40.3-0.10.20.2-0.0-0.0
Mn content in liver2.12.33.21.4-1.7-1.6-1.8-1.8-1.6-1.6-0.8-1.0
Na content in liver0.30.31.0-1.00.80.70.5-0.20.1-0.0-0.6-0.5
Rb content in liver0.20.20.5-0.40.70.60.60.50.30.3-0.3-0.2
Se content in liver3.64.27.52.7-2.7-2.7-2.5-1.6-1.8-1.90.0-0.2
Sr content in liver0.50.51.5-0.4-0.2-0.2-0.4-1.2-0.6-0.7-0.8-1.0
Zn content in liver2.02.24.6-1.62.02.11.90.91.51.40.10.2
Bone: minimum diameter2.34.26.8-1.21.81.32.22.62.42.51.92.1
Time in familiar zone, hab. session 10.20.20.3-0.50.40.40.50.50.60.40.50.5
Time in novel zone, hab. session 10.20.20.30.5-0.5-0.5-0.40.2-0.1-0.40.30.3
Total zone transitions, hab. session 10.50.71.2-0.3-0.3-0.6-0.6-1.1-1.0-1.0-1.1-1.0
Total locomotion distance, hab. session 11.21.74.40.10.20.20.71.71.41.42.02.1
Locomotion velocity, hab. session 10.81.12.90.20.20.10.61.31.11.21.61.7
Time in familiar zone, hab. session 21.92.04.8-2.11.62.21.51.31.01.2-0.00.2
Time in novel zone, hab. session 21.21.22.31.5-1.1-1.5-1.1-1.4-0.8-1.0-0.3-0.5
Total zone transitions, hab. session 20.81.12.7-1.61.00.20.4-0.7-0.6-0.7-1.6-1.4
Total locomotion distance, hab. session 21.62.13.7-0.91.20.71.51.91.61.51.61.8
Locomotion velocity, hab. session 21.92.54.4-0.91.10.81.52.01.71.61.82.1
Novel to familiar place preference ratio0.20.21.1-0.30.5-0.30.51.0-0.00.00.00.3
Novelty place preference0.20.21.0-0.40.5-0.30.51.0-0.0-0.10.00.3
Time in novel zone, NPP test0.20.31.1-0.60.7-0.10.61.0-0.0-0.0-0.10.2
Total zone transitions, NPP test0.40.61.70.3-0.1-0.2-0.4-1.3-0.7-0.7-1.1-1.1
Total locomotion distance, NPP test0.81.02.80.60.10.20.50.81.21.11.71.6
Locomotion velocity, NPP test0.71.03.00.9-0.2-0.20.30.61.10.91.71.6
Intraocular pressure0.71.02.00.3-0.7-0.7-0.9-1.2-0.8-1.2-1.1-1.4
Delta distance traveled before/after self-admin1.11.13.2-1.50.80.50.2-0.5-0.8-0.7-1.8-1.6
Delta ambulatory time before/after self-admin1.01.23.6-1.30.60.50.0-0.7-0.8-0.9-1.9-1.7
Parametrial fat weight0.30.81.91.2-1.2-1.4-0.9-0.80.2-0.40.80.5
Pavlov. Cond. lever latency0.81.12.71.0-1.4-1.6-1.2-0.7-0.8-1.00.30.2
Pavlov. Cond. magazine entry latency2.43.19.3-2.32.33.02.00.91.31.3-0.5-0.3
Pavlov. Cond. change in total contacts1.11.23.1-1.31.51.81.31.00.80.8-0.3-0.1
Pavlov. Cond. index score2.02.56.6-1.82.12.61.90.91.31.3-0.4-0.2
Pavlov. Cond. latency score1.82.36.0-1.72.02.41.81.01.21.4-0.4-0.2
Pavlov. Cond. lever contacts0.91.12.5-1.21.41.61.20.70.91.0-0.2-0.1
Pavlov. Cond. magazine entry number2.43.08.42.1-2.3-2.9-2.0-1.0-1.3-1.30.50.3
Pavlov. Cond. intertrial magazine entries0.70.82.71.2-1.1-1.6-1.0-0.4-0.8-0.40.10.1
Pavlov. Cond. lever-magazine prob. diff.1.62.05.6-1.61.92.41.60.81.11.1-0.4-0.3
Pavlov. Cond. response bias1.21.44.5-1.51.52.11.40.60.90.8-0.3-0.2
Pavlov. Cond. lever latency10.514.230.05.5-5.4-5.2-4.6-1.8-2.5-2.71.61.1
Pavlov. Cond. magazine entry latency1.92.35.4-2.22.02.31.5-0.50.40.6-1.5-1.3
Pavlov. Cond. change in total contacts6.811.026.8-5.24.84.44.01.42.02.0-1.6-1.1
Pavlov. Cond. index score7.39.820.7-4.54.54.43.81.22.02.1-1.5-1.1
Pavlov. Cond. latency score6.28.217.4-4.24.24.03.40.91.81.8-1.5-1.2
Pavlov. Cond. lever contacts9.813.528.5-5.35.35.04.51.92.52.6-1.5-0.9
Pavlov. Cond. magazine entry number3.44.29.63.1-2.8-3.0-2.10.2-0.7-0.61.81.6
Pavlov. Cond. intertrial magazine entries1.21.83.9-0.61.00.41.32.01.61.61.51.6
Pavlov. Cond. lever-magazine prob. diff.7.19.519.8-4.44.54.43.81.32.12.1-1.3-0.9
Pavlov. Cond. response bias9.913.428.1-5.35.25.34.41.42.32.5-1.8-1.3
Time in closed arm before self-admin1.21.64.3-1.80.80.60.1-0.8-1.1-1.0-2.1-1.8
Time in closed arm after self-admin0.90.91.60.8-1.3-1.1-1.2-0.7-1.2-1.1-0.4-0.4
Time in open arm before self-admin2.32.57.82.8-2.2-1.9-1.7-0.9-0.3-0.41.30.8
Time in open arm after self-admin0.60.61.4-0.40.60.60.80.71.20.90.80.8
Bone: periosteal estimation1.43.04.6-1.41.91.62.11.92.02.10.91.1
Bone: periosteal perimeter1.52.64.1-1.51.91.62.01.51.82.00.80.9
Bone: post-yield work0.10.10.4-0.60.30.30.30.40.30.20.10.2
Progressive ratio test 1 active lever presses0.40.41.1-0.2-0.20.0-0.5-0.6-0.8-1.1-0.9-0.8
Progressive ratio test 1 breakpoint0.30.41.0-0.2-0.20.0-0.4-0.6-0.8-1.0-0.8-0.8
Progressive ratio test 1 inactive lever presses0.20.40.90.4-0.3-0.2-0.5-0.5-0.7-1.0-0.7-0.7
Progressive ratio test 2 active lever presses0.20.20.7-0.60.80.50.70.20.2-0.0-0.3-0.3
Progressive ratio test 2 breakpoint0.20.20.7-0.70.80.60.70.20.2-0.0-0.4-0.3
Progressive ratio test 2 inactive lever presses0.30.51.1-0.30.20.1-0.1-0.7-0.7-1.0-1.0-1.0
Incentive Sensitization - Responses0.40.51.4-0.81.20.71.10.60.60.6-0.00.1
Incentive Sensitization - Breakpoint0.30.41.2-0.71.10.61.00.40.50.4-0.1-0.1
Sum of active levers in priming session hrs 5-60.20.20.4-0.3-0.1-0.3-0.3-0.5-0.7-0.4-0.5-0.4
Progressive ratio0.30.51.1-0.50.20.8-0.1-1.0-0.4-0.3-1.0-1.0
Food seeking constrained by brief footshock1.62.03.1-1.71.71.61.71.21.51.50.60.7
Seeking ratio, punishment vs. effort1.72.43.7-1.01.40.81.71.91.91.71.51.7
Retroperitoneal fat weight1.45.817.91.7-0.9-0.70.32.02.42.04.24.0
Reaction time number correct0.71.32.3-0.0-0.4-1.2-0.8-1.2-1.5-1.4-1.4-1.3
Reaction time mean minus median0.41.01.8-0.81.21.31.21.00.91.10.30.4
Reaction time mean minus median AUC0.20.61.3-0.91.11.11.00.50.40.6-0.4-0.3
Reaction time num false alarms1.01.43.92.0-1.2-1.0-0.60.70.20.31.61.5
Reaction time num false alarms AUC0.60.93.82.0-1.1-0.8-0.60.40.00.11.00.9
Reaction time trials correct on left0.71.32.3-0.0-0.4-1.2-0.8-1.2-1.5-1.4-1.4-1.3
Reaction time trials on left0.71.32.30.0-0.5-1.1-0.8-1.3-1.5-1.4-1.4-1.3
Reaction time mean0.50.81.91.2-0.4-0.2-0.00.90.50.61.41.4
Reaction time mean AUC0.40.61.81.3-0.7-0.5-0.30.60.10.21.11.1
Median of all reaction times0.60.92.91.7-1.0-0.6-0.50.50.10.21.31.3
Reaction time omissions0.20.40.80.50.10.40.30.70.70.60.90.9
Reaction time false alarm rate0.91.33.71.9-0.9-0.3-0.30.80.70.71.71.5
Reaction time premature initiation rate3.34.67.0-1.82.12.22.42.22.52.61.51.6
Reaction time premature initiations1.01.72.7-1.41.61.41.61.11.41.60.50.5
Std. dev. reaction times1.12.03.5-0.21.11.21.41.91.61.71.51.6
Reaction time trials completed0.71.32.30.0-0.5-1.1-0.8-1.3-1.5-1.4-1.4-1.3
Reaction time trials AUC0.40.91.6-0.1-0.3-1.0-0.6-1.0-1.3-1.1-1.2-1.1
Run reversals in cocaine runway, females3.33.36.1-0.60.90.91.51.92.22.22.52.5
Run reversals in cocaine runway, males0.20.20.50.6-0.50.2-0.6-0.5-0.5-0.7-0.3-0.4
Latency to leave start box in cocaine runway1.11.33.51.0-1.2-1.3-0.60.30.50.41.91.7
Latency to leave start box in cocaine runway, F1.71.95.80.8-0.8-1.1-0.01.11.21.22.42.3
Latency to leave start box in cocaine runway, M0.50.51.00.8-0.9-0.5-0.9-1.0-0.5-0.6-0.2-0.4
Std. dev. time between licks in bursts3.34.56.6-1.42.01.72.42.52.52.61.82.0
Total sessions with >9 infusions1.51.84.4-2.11.91.91.50.50.70.3-0.9-0.7
Short access day 1 total inactive lever presses0.00.00.2-0.10.40.20.30.20.1-0.1-0.1-0.1
Short access day 10 total inactive lever presses0.20.62.31.5-1.0-0.6-0.9-0.3-0.5-0.40.20.2
Short access day 1 total infusions2.23.06.3-2.32.52.22.21.31.31.2-0.4-0.2
Short access day 10 total infusions1.11.53.4-1.81.71.81.40.50.60.5-0.7-0.5
Short access total infusions1.41.84.6-2.21.91.81.50.40.50.3-1.1-0.9
Short access day 1 locomotion0.91.13.0-0.81.01.30.5-0.6-0.3-0.6-1.7-1.7
Short access day 10 total locomotion0.40.72.4-0.91.31.51.00.10.40.3-0.5-0.4
Short access total locomotion0.50.51.4-0.40.30.60.0-0.7-0.5-0.8-1.2-1.2
One hour access (0.3 mA shock)0.50.61.6-0.91.11.30.8-0.10.20.1-0.8-0.8
Compulsive drug intake2.53.04.21.5-1.9-1.8-2.1-1.8-1.9-1.9-1.2-1.4
One hour access (shock baseline)1.11.63.5-1.81.91.91.50.30.70.7-0.7-0.5
Social response proportion0.50.51.40.9-0.2-0.50.20.40.60.61.21.1
Social responses1.11.43.40.60.30.20.81.51.21.21.81.8
Social time1.92.67.11.7-1.9-2.7-1.8-1.2-1.4-1.70.10.0
Soleus weight1.33.97.90.50.60.81.42.22.52.42.82.7
Bone: stiffness0.40.61.40.8-0.4-0.5-0.01.10.30.71.11.2
Tibialis anterior weight0.41.22.3-0.40.80.81.11.51.31.11.21.2
Time to tail flick, vehicle, before self-admin0.20.20.9-0.90.50.10.3-0.2-0.2-0.1-0.6-0.4
Time to tail flick, vehicle, after self-admin0.50.61.7-1.31.10.70.80.20.2-0.1-1.0-0.9
Time to tail flick, test, before self-admin1.71.83.8-2.01.41.21.51.51.31.50.60.8
Time to tail flick, test, after self-admin2.02.03.6-1.21.31.21.51.91.51.61.11.3
Delta time to tail flick, vehicle, before/after SA0.20.20.5-0.10.40.70.40.10.2-0.0-0.5-0.6
Delta time to tail flick, test, before/after SA0.40.41.51.2-0.7-0.7-0.6-0.2-0.3-0.40.40.2
Tibia length0.61.74.6-1.21.41.50.7-0.3-0.8-0.2-2.1-1.9
Ambulatory time before self-admin0.50.71.50.9-1.2-1.1-1.1-0.7-0.8-0.50.20.1
Ambulatory time after self-admin2.22.64.6-0.5-0.9-0.9-1.4-1.9-2.1-1.9-2.0-1.9
Bone: tissue strength2.62.64.60.9-1.4-1.5-1.7-2.1-1.9-1.8-1.4-1.5
Total heroin consumption0.10.10.2-0.40.2-0.00.0-0.2-0.4-0.1-0.4-0.3
Bone: trabecular number1.11.82.81.4-1.6-1.5-1.7-1.5-1.3-1.5-0.4-0.6
Bone: trabecular spacing0.30.40.8-0.60.80.90.5-0.60.10.3-0.8-0.8
Bone: trabecular thickness0.30.30.90.1-0.4-0.6-0.11.0-0.00.20.80.9
Bone: trabecular tissue density1.52.25.81.1-0.4-0.90.32.01.01.32.32.4
Water consumed over 24 hours0.20.30.50.6-0.7-0.6-0.7-0.4-0.5-0.60.0-0.0
Number of responses in last shaping day0.70.71.61.0-0.10.00.31.30.80.61.21.2