Hub : Genes

P2ry2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Eye gene expression P2ry2 0.52 0.23 2.6e-03 0.1 0.03 -0.01 0.07 1.3e-02 1.1e-01 4.2e-01 2.8e-02
2 Liver gene expression P2ry2 0.05 0.03 4.7e-04 0.03 0.03 0.02 0.02 5.7e-04 8.5e-04 3.3e-03 8.7e-04
3 Adipose mRNA stability P2ry2 0.12 0.06 5.4e-12 0.09 0.09 0.09 0.09 2.0e-10 1.8e-10 6.8e-10 4.1e-10
4 Adipose isoform ratio XM_006229757.4 0.06 0.04 1.5e-05 0.01 0.02 0.01 0.01 3.4e-02 4.3e-03 7.5e-03 7.7e-03
5 Adipose alternative TSS XM_006229757.4 0.06 0.04 2.9e-05 0.01 0.01 0.01 0.01 5.3e-02 1.2e-02 1.1e-02 2.1e-02
6 Adipose isoform ratio NM_017255.2 0.05 0.04 3.0e-04 0.01 0.01 0.01 0.01 5.6e-02 3.0e-02 1.8e-02 4.6e-02
7 Adipose alternative TSS NM_017255.2 0.06 0.04 1.1e-04 0.02 0.01 0.02 0.01 4.8e-03 2.1e-02 4.6e-03 3.0e-02
8 NAcc gene expression P2ry2 0.09 0.05 3.0e-08 0.06 0.05 0.04 0.06 1.2e-07 6.6e-07 3.8e-05 5.6e-07
9 Liver mRNA stability P2ry2 0.03 0.03 5.9e-03 0 0.01 0.01 0 1.0e-01 2.1e-02 6.5e-02 9.5e-02
10 BLA gene expression P2ry2 0.11 0.07 1.1e-04 0.03 0.07 0.06 0.05 6.3e-03 2.0e-04 2.6e-04 7.1e-04
11 Brain gene expression P2ry2 0.16 0.08 2.5e-12 0.11 0.12 0.12 0.11 4.3e-10 2.6e-11 5.2e-11 2.3e-10

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11
Bone: apparent density0.30.50.90.5-0.4-0.6-0.80.9-0.9-0.90.7-0.6-0.6-0.9
Area under the delay curve0.10.10.40.3-0.2-0.2-0.0-0.40.60.6-0.20.40.50.3
BMI with tail0.00.10.30.1-0.3-0.4-0.2-0.40.40.4-0.30.30.60.3
BMI without tail1.63.26.1-1.31.01.41.9-1.81.61.5-2.51.92.12.3
Body weight1.45.99.0-1.11.01.72.4-2.72.72.7-2.92.62.63.0
Weight adjusted by age1.01.11.6-0.90.91.01.2-1.21.01.0-1.30.80.91.2
Bone surface0.30.61.6-1.21.31.20.9-0.60.40.4-0.6-0.4-0.40.2
Bone volume0.20.40.9-0.91.00.90.7-0.70.60.6-0.4-0.3-0.40.2
Breakpoint value in progressive ratio session0.60.71.10.9-0.3-0.8-0.91.0-1.0-1.00.6-0.6-0.7-0.9
Number of licking bursts2.02.35.82.4-2.4-2.0-1.20.9-0.6-0.60.01.81.80.4
Context. condit. distance diff. score0.91.12.5-1.51.41.40.7-0.1-0.2-0.30.3-1.5-1.6-0.6
Locomotion velocity, session 11.31.42.50.6-0.6-1.0-1.31.5-1.6-1.61.3-1.0-0.9-1.3
Locomotion distance, session 10.50.61.6-0.80.90.5-0.00.4-0.6-0.60.5-1.3-1.2-0.8
Locomotion velocity, session 20.00.00.1-0.40.40.30.20.0-0.1-0.1-0.2-0.1-0.10.0
Locomotion distance, session 20.20.20.6-0.60.80.50.2-0.30.20.20.1-0.7-0.7-0.2
Locomotion velocity, session 30.50.61.6-0.50.60.4-0.10.5-0.6-0.60.9-1.1-1.3-0.9
Locomotion distance, session 31.01.12.8-0.70.70.4-0.20.8-1.0-1.10.9-1.7-1.7-1.3
Stereotopy head waving bouts, day 30.50.61.30.3-0.10.10.4-0.70.90.9-0.81.11.00.9
Stereotopy head waving duration, day 30.10.10.2-0.10.40.1-0.10.1-0.1-0.10.2-0.4-0.5-0.3
Locomotion velocity, session 70.40.40.60.6-0.6-0.7-0.70.8-0.8-0.80.7-0.3-0.3-0.6
Locomotion distance, session 70.10.10.20.4-0.4-0.3-0.1-0.30.50.5-0.10.40.40.3
Stereotopy head waving bouts, day 71.11.33.3-1.51.81.40.70.2-0.6-0.60.1-1.4-1.5-0.7
Stereotopy head waving duration, day 71.21.54.4-1.92.11.71.00.1-0.6-0.6-0.3-1.3-1.4-0.4
Locomotion velocity, session 80.30.41.0-0.90.91.00.6-0.10.0-0.00.2-0.6-0.8-0.2
Locomotion distance, session 80.91.33.1-1.81.71.71.0-0.60.30.2-0.1-1.3-1.4-0.3
Degree of sensitization distance3.03.05.20.2-0.20.41.2-1.92.32.3-1.82.22.22.1
Degree of sensitization stereotypy2.22.46.1-2.32.52.11.1-0.0-0.5-0.60.0-2.0-2.0-0.8
Conditioned locomotion0.20.20.70.4-0.4-0.3-0.2-0.50.80.80.7-0.1-0.3-0.1
Cocaine response after cond. corrected0.80.82.21.3-1.3-1.0-0.40.2-0.00.0-0.41.41.50.7
Cocaine response after cond. not corrected0.30.30.50.7-0.7-0.7-0.50.5-0.5-0.50.00.50.60.1
Cocaine response before conditioning1.31.54.1-1.21.10.6-0.20.8-1.2-1.20.9-2.0-1.9-1.4
Saline control response2.22.84.8-2.02.02.22.0-2.01.81.8-1.50.30.11.2
Bone: connectivity density0.91.43.20.2-0.1-0.6-1.01.5-1.8-1.81.0-1.3-1.1-1.4
Bone: cortical apparent density1.01.33.21.4-1.5-0.9-0.2-0.40.80.8-0.41.81.71.0
Bone: cortical area0.81.32.3-0.90.91.21.3-1.41.51.5-1.00.60.51.0
Bone: cortical porosity0.60.62.0-0.70.70.3-0.20.3-0.4-0.40.8-1.4-1.4-0.9
Bone: cortical porosity0.50.61.8-0.60.60.3-0.20.3-0.4-0.40.8-1.3-1.3-0.9
Bone: cortical thickness0.10.10.30.5-0.5-0.4-0.30.00.10.10.30.10.1-0.1
Bone: cortical thickness0.10.10.3-0.20.30.20.1-0.40.50.50.2-0.4-0.5-0.2
Bone: cortical tissue density0.91.23.01.4-1.5-0.9-0.2-0.40.80.8-0.31.71.60.9
Condit. Reinf. active minus inactive responses0.80.91.6-0.60.60.91.1-1.21.31.2-0.90.80.71.1
Condit. Reinf. active-inactive response ratio1.31.42.0-1.00.91.31.4-1.41.41.3-1.10.80.71.2
Condit. Reinf. active responses0.40.51.3-0.20.30.50.7-1.01.11.1-0.60.70.60.8
Condit. Reinf. inactive responses0.00.10.10.3-0.3-0.3-0.3-0.10.30.30.2-0.0-0.1-0.1
Incentive salience index mean0.70.91.6-0.70.60.91.0-1.21.31.2-0.90.60.61.0
Condit. Reinf. lever presses0.10.10.3-0.30.30.40.3-0.40.30.3-0.50.10.10.2
Condit. Reinf. active minus inactive responses5.67.013.5-3.63.73.73.2-2.72.32.2-2.4-0.0-0.11.7
Condit. Reinf. active-inactive response ratio0.91.02.6-1.61.61.51.2-0.80.50.4-0.8-0.4-0.40.3
Condit. Reinf. active responses8.311.520.3-4.34.44.54.1-3.73.33.2-3.20.30.22.4
Condit. Reinf. inactive responses5.97.311.2-3.13.13.33.2-3.13.03.0-2.60.60.52.2
Condit. Reinf. lever presses10.514.331.9-5.65.65.44.4-3.73.02.9-2.8-1.2-1.21.7
Condit. Reinf. lever reinforcers received8.311.722.0-4.64.64.74.2-3.63.13.0-3.20.0-0.12.3
Conditioned reinforcement - actives1.01.02.8-1.51.20.90.3-0.30.10.10.4-1.7-1.6-0.7
Conditioned reinforcement - inactives0.30.30.60.2-0.5-0.00.2-0.70.80.8-0.40.60.60.6
Conditioned locomotion1.21.44.4-1.31.40.90.10.3-0.6-0.60.6-2.1-2.1-1.2
Patch foraging indifference point 0 sec1.62.66.4-2.52.42.21.5-1.61.11.1-0.9-1.3-1.20.2
Patch foraging indifference point AUC1.01.21.8-0.30.50.71.0-1.21.31.4-1.21.21.11.2
Delay disc. indifference point, 0s delay0.70.71.1-1.01.11.11.0-1.01.01.0-0.70.0-0.00.6
Delay disc. indifference point, 16s delay0.10.10.30.5-0.5-0.4-0.3-0.20.50.50.50.0-0.0-0.1
Delay disc. indifference point, 2s delay0.91.01.5-0.90.91.21.2-1.11.11.1-1.10.60.61.0
Delay disc. indifference point, 24s delay0.60.61.81.3-1.3-1.1-0.80.20.20.30.80.50.4-0.1
Delay disc. indifference point, 4s delay1.81.92.5-1.01.31.31.5-1.61.61.5-1.61.00.91.4
Delay disc. indifference point, 8s delay0.00.10.20.00.0-0.1-0.1-0.30.40.5-0.10.00.10.1
Indifference point function ln k1.11.54.3-0.80.50.2-0.60.7-0.9-0.91.4-2.1-2.1-1.5
Indifference point function log k1.11.54.3-0.80.50.2-0.60.7-0.9-0.91.4-2.1-2.1-1.5
Patch foraging total patch changes 0 sec1.32.15.2-2.32.21.91.4-1.51.11.1-1.0-1.1-1.00.3
Patch foraging total patch changes 12 sec2.22.94.8-1.41.61.71.8-2.22.12.0-1.80.80.81.6
Patch foraging total patch changes 18 sec1.31.73.5-1.71.91.61.4-1.61.31.3-1.2-0.3-0.20.7
Patch foraging total patch changes 24 sec2.12.63.9-1.41.61.61.8-2.01.91.9-1.90.70.81.5
Patch foraging total patch changes 6 sec0.20.30.8-0.90.90.70.5-0.60.40.4-0.4-0.5-0.40.1
Patch foraging time to switch 0 sec2.03.17.22.7-2.6-2.5-2.11.8-1.4-1.31.30.50.5-0.8
Patch foraging water rate 0 sec1.32.05.6-2.42.22.01.5-1.30.90.8-0.6-1.1-1.10.2
Patch foraging water rate 12 sec0.81.23.4-1.81.71.30.7-0.60.20.20.2-1.5-1.4-0.4
Patch foraging water rate 18 sec1.11.43.4-1.81.71.81.5-1.00.70.7-1.1-0.1-0.20.7
Patch foraging water rate 24 sec0.60.92.9-1.00.70.4-0.20.1-0.3-0.31.0-1.7-1.6-1.0
Patch foraging water rate 6 sec0.50.71.9-1.41.20.90.4-0.20.00.00.2-1.2-1.2-0.4
Seeking ratio, delayed vs. immediate footshock1.82.03.91.3-1.4-1.6-1.61.9-2.0-2.00.8-0.5-0.4-1.2
Distance traveled before self-admin0.60.61.51.2-1.1-1.2-0.80.6-0.3-0.30.00.80.90.1
Distance traveled after self-admin1.41.52.90.8-0.7-0.8-1.11.7-1.6-1.61.3-1.0-1.2-1.4
Extensor digitorum longus weight0.31.03.00.10.00.10.7-0.70.70.7-1.41.61.71.4
Bone: elastic displacement2.52.84.21.9-1.9-2.0-1.92.0-1.9-1.91.6-0.3-0.3-1.3
Bone: elastic work3.44.37.12.0-1.9-2.3-2.42.6-2.7-2.61.9-0.8-0.6-1.8
Bone: endosteal estimation1.73.75.3-2.12.12.22.3-2.11.91.9-2.20.90.91.8
Bone: endosteal perimeter1.83.86.0-2.32.32.42.4-2.11.91.9-2.20.60.61.7
Epididymis fat weight0.71.75.10.5-0.7-0.20.6-0.91.01.0-1.42.12.31.7
Delta time in closed arm before/after self-admin2.92.86.90.6-0.4-0.20.8-1.51.81.9-1.72.52.62.1
Delta time in open arm before/after self-admin1.81.74.5-2.12.02.01.5-1.10.80.8-0.7-0.8-0.80.3
Diff in mean of infusions in LGA sessions1.01.13.51.9-1.4-1.2-0.70.8-0.5-0.6-0.11.41.20.3
Delay discount exponential model param0.10.10.3-0.30.20.30.10.4-0.5-0.60.2-0.4-0.5-0.3
Extinction: sum of active levers before priming0.00.00.10.3-0.2-0.2-0.10.3-0.3-0.20.10.20.20.0
Active lever presses in extinction session 62.01.96.0-0.71.00.3-0.50.9-1.1-1.11.2-2.4-2.5-1.8
Bone: final force0.30.41.40.1-0.10.10.3-0.91.21.2-0.10.50.40.6
Bone: final moment0.30.51.6-0.20.20.40.5-1.01.21.2-0.20.40.30.6
Food consumed during 24 hour testing period1.41.74.2-2.02.01.70.8-0.2-0.3-0.3-0.1-1.8-1.8-0.7
Glucose0.30.51.40.0-0.2-0.1-0.40.9-1.2-1.20.5-0.6-0.5-0.7
Heart weight0.40.61.8-1.31.21.10.7-0.40.10.10.0-0.8-0.8-0.1
Delay discount hyperbolic model param0.20.20.6-0.1-0.1-0.0-0.20.6-0.7-0.70.5-0.6-0.6-0.5
Intermittent access intake day 1-15 change0.40.40.8-0.90.70.60.30.3-0.7-0.7-0.0-0.7-0.6-0.3
Intermittent access intake escalation0.40.40.9-0.90.80.60.20.4-0.7-0.70.1-0.8-0.7-0.4
Intermittent access intake escalation 20.30.30.8-0.70.50.40.5-0.50.30.3-0.90.30.50.7
Intermitt. access day 1 inactive lever presses0.30.40.70.3-0.6-0.20.1-0.70.80.8-0.50.70.80.7
Intermitt. access day 15 inactive lever presses0.20.20.9-0.10.30.2-0.10.2-0.2-0.20.5-0.8-0.9-0.7
Intermitt. access escalation Index0.20.20.5-0.50.60.50.4-0.50.50.5-0.7-0.2-0.10.2
Intermittent access day 1 total infusions0.91.02.6-1.41.61.41.1-1.00.90.9-0.6-0.4-0.50.3
Intermittent access day 15 total infusions0.80.92.4-1.51.51.30.9-0.70.50.5-0.2-0.9-1.0-0.1
Intermittent access terminal intake (last 3 days)0.90.92.5-1.41.61.41.0-0.80.70.7-0.6-0.6-0.60.3
Intermittent access total infusions0.80.92.0-1.41.41.31.0-0.90.80.8-0.5-0.5-0.50.3
Intermittent access day 1 locomotion0.10.10.5-0.10.30.1-0.10.2-0.2-0.20.4-0.6-0.7-0.5
Intermittent access day 15 total locomotion0.50.61.5-1.01.10.80.20.0-0.3-0.30.4-1.2-1.2-0.6
Intermittent access total locomotion0.30.40.9-0.90.90.80.5-0.30.30.20.2-0.7-0.7-0.2
Intermittent access standard deviation0.00.00.1-0.30.20.20.2-0.10.10.1-0.30.10.20.3
Left kidney weight1.54.27.7-1.82.02.02.4-2.12.02.0-2.81.51.62.3
Right kidney weight1.13.04.6-1.41.51.61.9-1.91.91.9-2.21.41.42.0
Cocaine induced anxiety1.11.33.82.0-1.9-1.8-1.30.6-0.1-0.10.70.70.7-0.2
Post-drug Anxiety0.50.51.50.9-0.6-0.5-0.0-0.30.60.6-0.41.21.10.7
Baseline Anxiety1.31.43.1-1.61.81.71.5-1.00.80.7-1.10.10.10.8
Tail length5.115.623.7-3.23.04.24.9-4.23.93.8-4.73.43.24.5
Length with tail3.412.317.0-2.12.23.34.1-3.93.93.8-4.03.43.14.1
Length without tail0.10.10.50.7-0.5-0.4-0.2-0.10.30.30.30.40.20.0
Times rat made contact with spout0.40.51.40.3-0.30.10.4-0.20.20.2-0.91.21.20.9
Lifetime Intake1.01.12.6-1.61.61.51.1-1.00.80.8-0.4-0.6-0.60.3
Liver weight, left1.62.54.70.4-0.30.00.8-1.62.02.0-1.62.12.21.9
Liver weight, right2.94.810.70.6-0.50.21.4-2.02.42.4-2.23.33.22.8
Locomotor activity0.20.40.9-0.70.90.70.5-0.70.60.6-0.3-0.5-0.60.0
Locomotor testing distance1.32.14.4-1.92.11.91.7-1.61.41.4-1.4-0.2-0.30.8
Locomotor testing rearing1.52.33.1-1.11.41.51.7-1.71.81.7-1.81.00.91.5
Locomotion in novel chamber0.70.82.6-0.20.2-0.5-0.90.5-0.5-0.51.2-1.6-1.4-1.2
Locomotion in novel chamber post-restriction1.01.23.1-1.41.40.90.20.3-0.7-0.70.2-1.8-1.6-0.9
Fecal boli incidents, locomotor time 10.40.52.0-0.70.6-0.1-0.5-0.30.20.30.6-1.4-1.1-0.7
Change in fecal boli incidents, locomotor task0.30.31.01.0-0.8-0.5-0.20.3-0.2-0.20.20.80.70.2
Time >=10cm from walls, locomotor time 10.70.81.4-1.11.00.80.4-0.90.80.80.2-1.2-1.2-0.4
Bouts of movement, locomotor time 10.10.10.2-0.30.40.30.2-0.40.40.4-0.1-0.3-0.4-0.0
Total resting periods, locomotor time 10.20.20.7-0.00.1-0.1-0.40.1-0.1-0.10.5-0.8-0.8-0.6
Rest time, locomotor task time 10.30.30.70.3-0.1-0.3-0.50.6-0.5-0.50.8-0.6-0.8-0.8
Distance moved, locomotor task time 10.70.81.8-0.60.30.60.9-0.90.70.7-1.31.01.11.1
Vertical activity count, locomotor time 10.91.01.9-0.90.40.81.0-1.41.31.2-1.10.60.71.0
Time >=10cm from walls, locomotor time 21.71.83.2-1.41.51.71.5-1.71.81.8-0.5-0.1-0.20.8
Bouts of movement, locomotor time 22.12.34.4-0.60.61.01.4-2.02.12.1-1.41.41.31.8
Total resting periods, locomotor time 21.51.63.2-0.10.20.61.1-1.61.81.8-1.21.31.31.5
Rest time, locomotor task time 21.72.04.72.2-2.0-2.0-1.61.4-1.1-1.11.10.40.4-0.6
Distance moved, locomotor task time 22.42.86.1-2.52.32.32.0-1.61.31.3-1.6-0.1-0.11.1
Vertical activity count, locomotor time 22.12.24.1-1.71.21.51.6-2.01.91.9-1.20.60.61.4
Light reinforcement 11.52.86.62.4-2.6-2.3-1.81.7-1.5-1.50.70.80.9-0.5
Light reinforcement 21.52.04.60.9-1.0-1.2-1.41.9-2.1-2.10.9-0.8-0.7-1.3
Bone: marrow area1.53.34.7-1.91.92.02.2-2.01.81.8-2.21.01.01.8
Bone: maximum diameter1.73.25.5-2.12.12.32.2-2.01.81.8-1.70.40.31.4
Bone: maximum force0.10.20.6-0.20.20.40.4-0.70.80.8-0.20.30.20.4
Bone: maximum moment0.20.30.6-0.50.50.60.6-0.70.80.8-0.40.20.10.5
Mean time between licks in bursts7.710.916.4-3.23.23.63.8-4.14.04.0-3.11.41.33.1
Mean num. licks in bursts1.61.95.1-2.22.22.01.3-0.90.60.6-0.3-1.4-1.5-0.2
Cd content in liver0.30.41.30.5-0.5-0.4-0.00.1-0.1-0.1-0.71.01.20.6
Co content in liver2.12.53.8-1.71.71.91.9-1.91.81.8-1.40.60.51.4
Cu content in liver1.41.72.6-1.31.31.51.6-1.41.31.3-1.40.80.81.4
Fe content in liver0.00.10.10.1-0.00.10.2-0.20.20.2-0.20.40.30.3
K content in liver0.40.40.80.2-0.2-0.10.3-0.60.90.9-0.30.80.80.7
Mg content in liver0.10.20.3-0.50.40.40.4-0.50.50.5-0.10.00.10.3
Mn content in liver2.02.33.61.6-1.7-1.8-1.91.7-1.5-1.51.7-0.7-0.7-1.5
Na content in liver0.20.20.4-0.60.50.40.10.3-0.4-0.40.2-0.6-0.6-0.4
Rb content in liver0.50.61.6-1.11.31.21.0-0.70.50.4-0.6-0.1-0.10.4
Se content in liver2.22.75.62.3-2.4-2.3-2.01.7-1.4-1.31.50.30.3-0.9
Sr content in liver0.70.71.40.1-0.2-0.4-0.71.0-1.2-1.20.7-0.9-0.8-1.0
Zn content in liver2.12.46.7-2.62.52.11.6-1.30.90.9-0.8-1.0-0.80.4
Bone: minimum diameter2.24.15.7-1.21.21.82.2-2.32.32.3-2.31.91.82.4
Time in familiar zone, hab. session 10.10.10.2-0.20.10.30.4-0.20.10.1-0.40.50.50.5
Time in novel zone, hab. session 10.10.10.30.6-0.5-0.5-0.30.10.00.00.10.30.30.0
Total zone transitions, hab. session 10.71.02.00.3-0.2-0.3-0.71.2-1.4-1.41.1-1.0-1.1-1.2
Total locomotion distance, hab. session 11.21.84.30.5-0.50.10.8-1.21.41.3-1.32.12.01.7
Locomotion velocity, hab. session 10.91.32.80.4-0.30.20.8-1.21.41.3-1.11.71.61.5
Time in familiar zone, hab. session 21.51.62.5-1.61.61.51.4-1.51.51.4-0.9-0.0-0.00.8
Time in novel zone, hab. session 20.80.81.20.9-0.9-1.0-1.11.0-1.1-1.10.7-0.4-0.3-0.8
Total zone transitions, hab. session 20.70.92.6-1.01.11.00.30.4-0.7-0.70.4-1.4-1.6-0.9
Total locomotion distance, hab. session 22.02.74.8-0.40.41.11.6-2.02.22.2-1.61.71.51.9
Locomotion velocity, hab. session 22.23.05.0-0.30.31.11.7-2.02.22.2-1.72.01.82.1
Novel to familiar place preference ratio0.40.41.4-0.20.10.40.5-1.01.21.20.00.2-0.10.4
Novelty place preference0.40.41.4-0.20.10.50.5-1.01.21.20.10.2-0.10.4
Time in novel zone, NPP test0.50.51.7-0.30.30.60.6-1.11.31.30.00.1-0.20.4
Total zone transitions, NPP test0.40.61.2-0.20.30.0-0.40.7-1.0-1.00.5-1.1-1.1-0.9
Total locomotion distance, NPP test1.01.42.70.3-0.30.10.7-1.21.41.4-1.31.61.61.5
Locomotion velocity, NPP test0.91.23.00.6-0.6-0.20.4-1.01.11.1-1.21.71.71.4
Intraocular pressure1.31.84.3-0.10.2-0.5-1.01.6-2.1-2.11.1-1.4-1.2-1.4
Delta distance traveled before/after self-admin0.80.82.3-1.11.21.30.7-0.0-0.2-0.20.4-1.2-1.5-0.6
Delta ambulatory time before/after self-admin1.01.13.6-0.90.91.00.30.3-0.6-0.60.8-1.6-1.9-1.1
Parametrial fat weight0.40.83.00.8-0.8-0.7-0.20.3-0.4-0.3-1.01.51.70.9
Pavlov. Cond. lever latency0.81.02.21.4-1.5-1.3-1.11.0-0.9-0.90.90.30.3-0.4
Pavlov. Cond. magazine entry latency2.02.65.4-2.32.32.21.9-1.61.41.4-1.4-0.4-0.40.8
Pavlov. Cond. change in total contacts1.11.22.4-1.51.51.51.3-1.11.01.0-0.9-0.2-0.20.6
Pavlov. Cond. index score1.92.45.3-2.22.32.21.8-1.51.21.2-1.5-0.3-0.30.8
Pavlov. Cond. latency score1.92.45.2-2.22.32.11.8-1.51.31.3-1.4-0.4-0.30.8
Pavlov. Cond. lever contacts1.01.22.4-1.41.51.41.2-1.10.90.9-1.2-0.00.00.7
Pavlov. Cond. magazine entry number1.92.35.92.4-2.4-2.2-1.71.3-1.0-1.01.20.70.7-0.5
Pavlov. Cond. intertrial magazine entries0.60.71.71.2-1.3-1.1-0.90.9-0.7-0.80.60.30.2-0.4
Pavlov. Cond. lever-magazine prob. diff.1.51.84.3-2.02.11.91.6-1.21.01.0-1.3-0.4-0.30.6
Pavlov. Cond. response bias0.91.22.3-1.51.51.41.3-1.10.90.9-1.1-0.1-0.00.7
Pavlov. Cond. lever latency9.713.030.75.5-5.5-5.2-4.23.3-2.6-2.52.51.51.5-1.4
Pavlov. Cond. magazine entry latency1.61.85.4-2.32.21.91.2-0.60.20.2-0.2-1.5-1.4-0.2
Pavlov. Cond. change in total contacts6.69.123.2-4.84.84.63.5-2.41.71.6-1.7-1.7-1.80.7
Pavlov. Cond. index score7.08.922.6-4.84.74.43.4-2.61.91.9-1.8-1.6-1.60.9
Pavlov. Cond. latency score6.07.419.4-4.44.34.03.1-2.31.61.6-1.6-1.6-1.60.7
Pavlov. Cond. lever contacts10.013.632.2-5.75.75.44.3-3.42.62.5-2.5-1.6-1.61.4
Pavlov. Cond. magazine entry number2.93.510.03.2-3.1-2.7-1.81.0-0.4-0.40.41.91.90.2
Pavlov. Cond. intertrial magazine entries1.21.62.8-0.50.50.91.3-1.31.31.3-1.71.51.51.6
Pavlov. Cond. lever-magazine prob. diff.6.78.621.4-4.64.64.33.4-2.62.01.9-1.8-1.4-1.41.0
Pavlov. Cond. response bias9.513.031.9-5.65.65.34.1-3.12.42.3-2.3-1.8-1.81.1
Time in closed arm before self-admin1.92.27.3-0.81.00.6-0.40.8-1.0-1.01.5-2.5-2.7-1.9
Time in closed arm after self-admin0.70.71.41.2-0.9-1.2-1.20.8-0.4-0.31.0-0.4-0.5-0.9
Time in open arm before self-admin2.12.36.12.2-2.5-2.2-1.40.9-0.8-0.70.21.61.80.4
Time in open arm after self-admin0.80.81.6-0.70.40.71.0-1.00.70.7-1.01.01.11.3
Bone: periosteal estimation1.63.24.5-1.91.92.12.1-2.11.91.9-2.00.80.81.7
Bone: periosteal perimeter1.52.53.8-1.81.82.01.9-1.81.61.6-1.60.40.41.3
Bone: post-yield work0.10.10.3-0.50.50.50.4-0.40.40.3-0.3-0.2-0.20.1
Progressive ratio test 1 active lever presses0.00.00.10.1-0.2-0.1-0.10.3-0.3-0.30.3-0.0-0.1-0.2
Progressive ratio test 1 breakpoint0.00.00.00.0-0.10.00.10.2-0.1-0.10.10.20.10.0
Progressive ratio test 1 inactive lever presses0.30.30.7-0.80.60.70.5-0.70.60.6-0.1-0.3-0.30.2
Progressive ratio test 2 active lever presses0.60.71.3-1.11.11.11.0-0.90.90.9-0.4-0.0-0.10.5
Progressive ratio test 2 breakpoint0.70.81.5-1.11.21.21.1-1.00.90.9-0.50.0-0.00.6
Progressive ratio test 2 inactive lever presses0.40.41.1-0.90.70.70.3-0.40.30.40.5-1.0-1.0-0.4
Incentive Sensitization - Responses1.92.03.0-1.61.71.71.6-1.71.61.6-1.00.10.11.0
Incentive Sensitization - Breakpoint1.41.52.5-1.51.61.61.4-1.41.31.3-0.9-0.1-0.10.8
Sum of active levers in priming session hrs 5-60.30.30.60.8-0.4-0.4-0.50.8-0.7-0.70.6-0.2-0.5-0.6
Progressive ratio0.40.40.80.1-0.1-0.3-0.60.8-0.9-0.90.4-0.8-0.7-0.8
Food seeking constrained by brief footshock1.41.72.6-1.21.31.51.6-1.31.31.3-1.50.80.71.3
Seeking ratio, punishment vs. effort2.22.63.7-1.21.11.51.9-1.91.91.9-1.71.31.31.9
Retroperitoneal fat weight3.110.228.71.5-1.5-0.41.5-2.12.72.7-3.55.35.44.1
Reaction time number correct0.71.02.40.2-0.2-0.5-0.90.8-0.7-0.71.5-1.3-1.4-1.3
Reaction time mean minus median0.81.12.0-1.11.01.11.1-1.41.41.4-0.90.20.30.9
Reaction time mean minus median AUC0.60.81.6-1.21.01.10.9-1.11.11.1-0.3-0.5-0.50.3
Reaction time num false alarms0.91.22.61.6-1.5-1.3-0.5-0.10.60.6-0.31.61.60.8
Reaction time num false alarms AUC0.50.71.61.3-1.2-1.2-0.6-0.00.50.5-0.01.01.00.4
Reaction time trials correct on left0.71.02.40.2-0.2-0.5-0.90.8-0.7-0.71.5-1.3-1.4-1.3
Reaction time trials on left0.71.02.40.2-0.2-0.5-0.90.8-0.7-0.71.6-1.4-1.4-1.3
Reaction time mean0.71.01.90.8-0.9-0.50.1-0.91.31.4-0.31.41.31.0
Reaction time mean AUC0.50.71.41.0-1.2-0.8-0.3-0.50.80.90.01.21.10.6
Median of all reaction times0.71.02.01.3-1.4-1.1-0.4-0.51.01.00.11.31.20.7
Reaction time omissions0.20.30.60.7-0.6-0.5-0.1-0.10.40.5-0.10.70.80.5
Reaction time false alarm rate0.81.12.81.2-1.1-0.9-0.2-0.40.80.8-0.81.61.71.0
Reaction time premature initiation rate3.34.47.4-1.91.82.12.4-2.32.22.2-2.71.41.52.3
Reaction time premature initiations1.42.02.8-1.71.61.61.6-1.61.61.6-1.50.30.41.2
Std. dev. reaction times1.72.44.6-0.80.61.01.4-2.02.12.1-1.41.41.41.8
Reaction time trials completed0.71.02.40.2-0.2-0.5-0.90.8-0.7-0.71.6-1.4-1.4-1.3
Reaction time trials AUC0.40.61.60.1-0.1-0.4-0.70.5-0.4-0.41.3-1.1-1.2-1.1
Run reversals in cocaine runway, females3.73.67.4-0.40.40.91.7-1.61.71.7-2.42.72.72.6
Run reversals in cocaine runway, males0.10.10.40.3-0.2-0.4-0.50.3-0.3-0.20.6-0.3-0.2-0.5
Latency to leave start box in cocaine runway0.90.92.51.3-1.3-1.1-0.50.4-0.3-0.2-0.31.51.60.6
Latency to leave start box in cocaine runway, F1.11.24.11.0-0.8-0.50.2-0.20.40.4-0.92.02.01.2
Latency to leave start box in cocaine runway, M0.70.71.10.7-0.8-1.0-1.01.0-1.0-1.00.8-0.5-0.4-0.8
Std. dev. time between licks in bursts4.25.07.5-1.61.62.02.4-2.72.72.7-2.51.71.72.5
Total sessions with >9 infusions1.31.43.9-2.01.91.60.8-0.3-0.1-0.10.3-1.6-1.5-0.5
Short access day 1 total inactive lever presses0.00.10.20.0-0.4-0.1-0.1-0.20.20.20.4-0.2-0.2-0.1
Short access day 10 total inactive lever presses0.10.10.30.4-0.5-0.6-0.5-0.00.10.20.3-0.1-0.0-0.2
Short access day 1 total infusions1.71.84.5-2.11.91.81.5-1.41.21.2-0.6-0.5-0.50.6
Short access day 10 total infusions1.31.43.1-1.61.81.71.4-1.21.01.0-0.9-0.1-0.10.7
Short access total infusions0.91.02.4-1.61.51.51.2-1.00.80.8-0.6-0.3-0.30.5
Short access day 1 locomotion1.31.44.0-1.20.80.5-0.20.6-1.0-1.01.0-2.0-1.8-1.3
Short access day 10 total locomotion0.20.20.3-0.60.50.60.6-0.60.50.5-0.30.10.10.4
Short access total locomotion0.10.10.2-0.30.20.20.00.2-0.4-0.40.4-0.4-0.4-0.3
One hour access (0.3 mA shock)1.41.73.8-1.81.91.61.3-1.51.31.3-0.9-0.6-0.40.6
Compulsive drug intake0.90.91.30.6-0.4-0.9-1.10.9-1.0-1.01.1-1.0-0.8-1.1
One hour access (shock baseline)1.72.03.2-1.81.71.81.6-1.71.61.6-1.20.0-0.01.0
Social response proportion0.60.71.30.1-0.2-0.00.4-0.81.11.1-0.81.11.11.1
Social responses1.82.34.4-0.1-0.10.41.1-1.82.12.1-1.41.81.81.9
Social time1.52.04.72.1-2.2-2.0-1.71.2-0.9-0.91.60.20.1-0.8
Soleus weight1.54.38.0-0.30.40.71.6-2.22.32.3-2.82.52.72.7
Bone: stiffness0.81.22.60.2-0.20.20.7-1.31.61.6-0.81.41.21.3
Tibialis anterior weight0.41.32.4-0.60.60.91.2-1.41.61.6-1.11.01.01.3
Time to tail flick, vehicle, before self-admin0.20.20.70.50.10.1-0.10.9-0.8-0.80.3-0.1-0.4-0.4
Time to tail flick, vehicle, after self-admin1.31.42.9-1.71.61.30.50.3-0.7-0.80.4-1.7-1.7-0.8
Time to tail flick, test, before self-admin0.60.61.8-0.71.01.11.1-0.40.30.3-1.30.40.30.6
Time to tail flick, test, after self-admin2.22.23.9-0.91.41.51.8-1.51.51.4-2.01.31.21.7
Delta time to tail flick, vehicle, before/after SA0.80.82.8-1.71.10.80.3-0.1-0.2-0.20.2-1.4-1.1-0.5
Delta time to tail flick, test, before/after SA0.10.10.30.3-0.1-0.3-0.0-0.20.30.3-0.10.50.60.4
Tibia length0.72.05.3-1.91.81.40.5-0.60.40.40.8-2.2-2.3-1.0
Ambulatory time before self-admin0.80.82.01.4-1.2-1.4-1.10.9-0.6-0.60.40.40.5-0.3
Ambulatory time after self-admin1.82.03.00.7-0.6-0.7-1.21.7-1.6-1.61.7-1.4-1.7-1.7
Bone: tissue strength2.52.53.80.8-0.7-1.2-1.61.9-2.0-2.01.8-1.5-1.5-1.8
Total heroin consumption0.20.20.7-0.30.70.50.2-0.20.30.20.1-0.6-0.8-0.4
Bone: trabecular number1.32.03.01.4-1.4-1.5-1.61.7-1.7-1.71.3-0.6-0.6-1.4
Bone: trabecular spacing0.30.41.1-1.10.90.80.5-0.30.00.0-0.3-0.8-0.7-0.1
Bone: trabecular thickness0.30.30.80.5-0.3-0.00.2-0.50.90.9-0.10.80.60.5
Bone: trabecular tissue density2.43.47.50.8-0.70.11.0-1.82.32.3-1.42.72.52.3
Water consumed over 24 hours0.60.71.21.0-1.1-1.0-0.91.1-1.0-1.00.8-0.0-0.1-0.6
Number of responses in last shaping day0.60.71.5-0.60.70.70.8-1.11.21.2-0.60.50.50.8