Hub : Traits

Incentive Sensitization - Responses

Tags: Behavior · Motivation · Progressive ratio

Project: p50_paul_meyer_2020

3 loci · 3 genes with independent associations · 3 total associated genes

Significant Loci

#	Chr	Start pos	End pos	# assoc genes	# joint models	Best TWAS P	Best GWAS P	Cond GWAS P	Joint genes
1	chr1	166093700	167491708	1	1	1.52e-09	5.25e-03	1.78e-08	Tead1
2	chr9	75969545	77365260	1	1	2.49e-70	3.47e-01	1.00e+00	Zfand2b
3	chr19	32676171	34074113	1	1	3.60e-08	1.56e-01	1.96e-02	Zdhhc1

Pleiotropic Associations

Trait	Chi2 ratio	# genes+	# genes++	% genes++	Corr	Corr P	Genes
BMI with tail	5.39	2	1	33.3	0	1e+00	Tead1 Zfand2b
BMI without tail	53.65	1	1	33.3	0	1e+00	Zfand2b
Epididymis fat weight	57.61	2	1	33.3	0	1e+00	Zdhhc1 Zfand2b
Heart weight	71.7	1	1	33.3	0	1e+00	Zfand2b
Left kidney weight	19.82	2	2	66.7	0	1e+00	Zdhhc1 Zfand2b
Right kidney weight	33.45	2	2	66.7	0	1e+00	Zdhhc1 Zfand2b
Tail length	125.62	1	1	33.3	0	1e+00	Zfand2b
Length with tail	4.78	1	0	0	0	1e+00	Zfand2b
Length without tail	77.43	1	1	33.3	0	1e+00	Zfand2b
Liver weight, right	17.57	1	1	33.3	0	1e+00	Zfand2b
Parametrial fat weight	9.74	2	0	0	0	1e+00	Zdhhc1 Zfand2b
Retroperitoneal fat weight	5.11	2	0	0	0	1e+00	Zdhhc1 Zfand2b
Intraocular pressure	28.08	2	1	33.3	0	1e+00	Zdhhc1 Zfand2b
Number of licking bursts	32.5	1	1	33.3	0	1e+00	Zfand2b
Food consumed during 24 hour testing period	15.78	1	0	0	0	1e+00	Zfand2b
Times rat made contact with spout	9.25	1	0	0	0	1e+00	Zfand2b
Mean time between licks in bursts	9.22	1	0	0	0	1e+00	Zfand2b
Mean num. licks in bursts	18.13	1	0	0	0	1e+00	Zfand2b
Std. dev. time between licks in bursts	12.12	1	0	0	0	1e+00	Zfand2b
Water consumed over 24 hours	34.33	1	1	33.3	0	1e+00	Zfand2b
Patch foraging indifference point 0 sec	11.19	2	0	0	0	1e+00	Tead1 Zfand2b
Patch foraging indifference point AUC	16.01	2	1	33.3	0	1e+00	Zdhhc1 Zfand2b
Indifference point function ln k	54.42	1	1	33.3	0	1e+00	Zfand2b
Indifference point function log k	54.42	1	1	33.3	0	1e+00	Zfand2b
Patch foraging total patch changes 0 sec	16.31	2	1	33.3	0	1e+00	Tead1 Zfand2b
Patch foraging total patch changes 12 sec	9.53	1	0	0	0	1e+00	Tead1
Patch foraging total patch changes 18 sec	48.28	1	1	33.3	0	1e+00	Zfand2b
Patch foraging total patch changes 24 sec	42.21	2	1	33.3	0	1e+00	Zdhhc1 Zfand2b
Patch foraging total patch changes 6 sec	11.87	3	1	33.3	0	1e+00	Tead1 Zdhhc1 Zfand2b
Patch foraging time to switch 0 sec	19.75	2	1	33.3	0	1e+00	Tead1 Zfand2b
Patch foraging water rate 0 sec	39.47	1	1	33.3	0	1e+00	Zfand2b
Patch foraging water rate 12 sec	69.49	1	1	33.3	0	1e+00	Zfand2b
Patch foraging water rate 18 sec	7.84	2	0	0	0	1e+00	Zdhhc1 Zfand2b
Patch foraging water rate 24 sec	10.78	2	0	0	0	1e+00	Tead1 Zfand2b
Patch foraging water rate 6 sec	20.78	2	1	33.3	0	1e+00	Zdhhc1 Zfand2b
Locomotor activity	10.45	2	0	0	0	1e+00	Zdhhc1 Zfand2b
Locomotor testing distance	47.2	1	1	33.3	0	1e+00	Zfand2b
Locomotor testing rearing	52.87	2	1	33.3	0	1e+00	Zdhhc1 Zfand2b
Light reinforcement 1	14.51	2	1	33.3	0	1e+00	Zdhhc1 Zfand2b
Light reinforcement 2	5.74	2	0	0	0	1e+00	Zdhhc1 Zfand2b
Reaction time number correct	60.58	2	1	33.3	0	1e+00	Zdhhc1 Zfand2b
Reaction time mean minus median	179.03	1	1	33.3	0	1e+00	Zfand2b
Reaction time mean minus median AUC	119.61	2	1	33.3	0	1e+00	Zdhhc1 Zfand2b
Reaction time num false alarms	5.7	1	0	0	0	1e+00	Zfand2b
Reaction time num false alarms AUC	27.43	1	1	33.3	0	1e+00	Zfand2b
Reaction time trials correct on left	60.58	2	1	33.3	0	1e+00	Zdhhc1 Zfand2b
Reaction time trials on left	56.77	2	1	33.3	0	1e+00	Zdhhc1 Zfand2b
Reaction time mean	21.51	3	2	66.7	0	1e+00	Tead1 Zdhhc1 Zfand2b
Reaction time mean AUC	26.7	2	1	33.3	0	1e+00	Zdhhc1 Zfand2b
Median of all reaction times	16.16	3	1	33.3	0	1e+00	Tead1 Zdhhc1 Zfand2b
Reaction time omissions	46.56	1	1	33.3	0	1e+00	Zfand2b
Reaction time premature initiations	41.6	1	1	33.3	0	1e+00	Zfand2b
Std. dev. reaction times	40.77	2	1	33.3	0	1e+00	Zdhhc1 Zfand2b
Reaction time trials completed	56.77	2	1	33.3	0	1e+00	Zdhhc1 Zfand2b
Reaction time trials AUC	57.6	2	1	33.3	0	1e+00	Zdhhc1 Zfand2b
Social response proportion	8.47	2	0	0	0	1e+00	Zdhhc1 Zfand2b
Conditioned locomotion	5.5	1	0	0	0	1e+00	Zdhhc1
Cocaine response after cond. corrected	12.71	1	0	0	0	1e+00	Zfand2b
Cocaine response after cond. not corrected	10.73	1	0	0	0	1e+00	Zfand2b
Saline control response	8.43	1	0	0	0	1e+00	Zfand2b
Condit. Reinf. lever presses	5.55	1	0	0	0	1e+00	Zfand2b
Conditioned reinforcement - actives	152.54	1	1	33.3	0	1e+00	Zfand2b
Conditioned reinforcement - inactives	72.86	2	1	33.3	0	1e+00	Tead1 Zfand2b
Conditioned locomotion	10.02	2	0	0	0	1e+00	Zdhhc1 Zfand2b
Intermittent access intake day 1-15 change	81.91	2	1	33.3	0	1e+00	Tead1 Zfand2b
Intermittent access intake escalation	117.41	1	1	33.3	0	1e+00	Zfand2b
Intermittent access intake escalation 2	7.7	1	0	0	0	1e+00	Tead1
Intermitt. access day 1 inactive lever presses	89.31	2	1	33.3	0	1e+00	Tead1 Zfand2b
Intermitt. access day 15 inactive lever presses	104.4	3	1	33.3	0	1e+00	Tead1 Zdhhc1 Zfand2b
Intermittent access day 1 total infusions	45.93	3	2	66.7	0	1e+00	Tead1 Zdhhc1 Zfand2b
Intermittent access day 15 total infusions	19.3	3	1	33.3	0	1e+00	Tead1 Zdhhc1 Zfand2b
Intermittent access terminal intake (last 3 days)	16.73	2	1	33.3	0	1e+00	Zdhhc1 Zfand2b
Intermittent access total infusions	29.48	2	1	33.3	0	1e+00	Tead1 Zdhhc1
Intermittent access day 1 locomotion	18.95	2	1	33.3	0	1e+00	Tead1 Zfand2b
Intermittent access day 15 total locomotion	93.08	1	1	33.3	0	1e+00	Zfand2b
Intermittent access total locomotion	9.82	2	0	0	0	1e+00	Tead1 Zfand2b
Intermittent access standard deviation	229.11	2	1	33.3	0	1e+00	Tead1 Zfand2b
Cocaine induced anxiety	125.35	1	1	33.3	0	1e+00	Zfand2b
Post-drug Anxiety	8.64	1	0	0	0	1e+00	Zdhhc1
Baseline Anxiety	393.92	1	1	33.3	0	1e+00	Zfand2b
Lifetime Intake	28.54	2	1	33.3	0	1e+00	Tead1 Zdhhc1
Incentive Sensitization - Breakpoint	121.83	3	3	100	0	1e+00	Tead1 Zdhhc1 Zfand2b
Progressive ratio test 1 active lever presses	21.26	3	2	66.7	0	1e+00	Tead1 Zdhhc1 Zfand2b
Progressive ratio test 1 breakpoint	21.61	2	0	0	0	1e+00	Tead1 Zfand2b
Progressive ratio test 1 inactive lever presses	5.93	2	0	0	0	1e+00	Tead1 Zdhhc1
Progressive ratio test 2 active lever presses	60.09	3	3	100	0	1e+00	Tead1 Zdhhc1 Zfand2b
Progressive ratio test 2 breakpoint	57.23	3	2	66.7	0	1e+00	Tead1 Zdhhc1 Zfand2b
Progressive ratio test 2 inactive lever presses	35.12	2	1	33.3	0	1e+00	Tead1 Zfand2b
Total sessions with >9 infusions	35.75	2	1	33.3	0	1e+00	Tead1 Zdhhc1
Short access day 1 total inactive lever presses	21.93	1	0	0	0	1e+00	Zfand2b
Short access day 10 total inactive lever presses	21.49	3	1	33.3	0	1e+00	Tead1 Zdhhc1 Zfand2b
Short access day 1 total infusions	15.66	2	0	0	0	1e+00	Tead1 Zdhhc1
Short access day 10 total infusions	55.42	2	1	33.3	0	1e+00	Tead1 Zdhhc1
Short access total infusions	31.58	2	1	33.3	0	1e+00	Tead1 Zdhhc1
Short access day 1 locomotion	69.81	2	1	33.3	0	1e+00	Tead1 Zfand2b
Short access day 10 total locomotion	432.47	1	1	33.3	0	1e+00	Zfand2b
Short access total locomotion	118.79	2	2	66.7	0	1e+00	Tead1 Zfand2b
Compulsive drug intake	45.32	2	1	33.3	0	1e+00	Tead1 Zfand2b
One hour access (0.3 mA shock)	22.58	1	0	0	0	1e+00	Zfand2b
One hour access (shock baseline)	14.65	1	0	0	0	1e+00	Zdhhc1
Number of responses in last shaping day	32.11	3	1	33.3	0	1e+00	Tead1 Zdhhc1 Zfand2b
Locomotion distance, session 2	4.45	1	0	0	0	1e+00	Zfand2b
Bone surface	3.9	1	0	0	0	1e+00	Zdhhc1
Bone volume	4.11	1	0	0	0	1e+00	Zdhhc1
Bone: cortical porosity	5.3	1	0	0	0	1e+00	Tead1
Bone: cortical porosity	7.17	1	0	0	0	1e+00	Tead1
Bone: elastic displacement	5.56	1	0	0	0	1e+00	Zfand2b
Breakpoint value in progressive ratio session	11.08	1	0	0	0	1e+00	Tead1
Distance traveled before self-admin	21.36	3	1	33.3	0	1e+00	Tead1 Zdhhc1 Zfand2b
Distance traveled after self-admin	10.31	2	0	0	0	1e+00	Tead1 Zfand2b
Delta time in open arm before/after self-admin	19.84	2	0	0	0	1e+00	Zdhhc1 Zfand2b
Extinction: sum of active levers before priming	6.15	1	0	0	0	1e+00	Zdhhc1
Active lever presses in extinction session 6	18.22	2	0	0	0	1e+00	Zdhhc1 Zfand2b
Delta ambulatory time before/after self-admin	11.38	2	0	0	0	1e+00	Zdhhc1 Zfand2b
Time in closed arm before self-admin	22.87	3	1	33.3	0	1e+00	Tead1 Zdhhc1 Zfand2b
Time in closed arm after self-admin	7.8	2	0	0	0	1e+00	Tead1 Zdhhc1
Time in open arm before self-admin	24.67	1	0	0	0	1e+00	Zfand2b
Sum of active levers in priming session hrs 5-6	6.97	1	0	0	0	1e+00	Zfand2b
Time to tail flick, vehicle, before self-admin	18.85	1	0	0	0	1e+00	Zdhhc1
Time to tail flick, vehicle, after self-admin	75.62	1	1	33.3	0	1e+00	Zfand2b
Time to tail flick, test, before self-admin	10.68	1	0	0	0	1e+00	Zfand2b
Time to tail flick, test, after self-admin	5.63	1	0	0	0	1e+00	Zfand2b
Delta time to tail flick, vehicle, before/after SA	40.25	2	1	33.3	0	1e+00	Tead1 Zfand2b
Ambulatory time before self-admin	22.98	3	1	33.3	0	1e+00	Tead1 Zdhhc1 Zfand2b
Ambulatory time after self-admin	19.2	1	0	0	0	1e+00	Tead1
Total heroin consumption	6.81	1	0	0	0	1e+00	Tead1
Area under the delay curve	31.15	1	1	33.3	0	1e+00	Zfand2b
Delay disc. indifference point, 0s delay	5.71	1	0	0	0	1e+00	Zfand2b
Delay disc. indifference point, 16s delay	69.03	1	1	33.3	0	1e+00	Zfand2b
Delay disc. indifference point, 2s delay	7.52	1	0	0	0	1e+00	Zdhhc1
Delay disc. indifference point, 24s delay	27.43	1	0	0	0	1e+00	Zfand2b
Delay disc. indifference point, 8s delay	74.24	1	1	33.3	0	1e+00	Zfand2b
Delay discount exponential model param	16.14	1	0	0	0	1e+00	Zfand2b
Delay discount hyperbolic model param	15.89	1	0	0	0	1e+00	Zfand2b
Fecal boli incidents, locomotor time 1	176.47	1	1	33.3	0	1e+00	Zfand2b
Time >=10cm from walls, locomotor time 1	47.52	2	1	33.3	0	1e+00	Zdhhc1 Zfand2b
Bouts of movement, locomotor time 1	6.19	1	0	0	0	1e+00	Zfand2b
Rest time, locomotor task time 1	8.65	2	0	0	0	1e+00	Zdhhc1 Zfand2b
Distance moved, locomotor task time 1	5.4	1	0	0	0	1e+00	Zdhhc1
Vertical activity count, locomotor time 1	97.7	1	1	33.3	0	1e+00	Zfand2b
Time >=10cm from walls, locomotor time 2	5.83	1	0	0	0	1e+00	Zdhhc1
Bouts of movement, locomotor time 2	23.9	1	0	0	0	1e+00	Zfand2b
Total resting periods, locomotor time 2	36.28	1	1	33.3	0	1e+00	Zfand2b
Rest time, locomotor task time 2	30.26	2	1	33.3	0	1e+00	Zdhhc1 Zfand2b
Distance moved, locomotor task time 2	50.91	2	1	33.3	0	1e+00	Zdhhc1 Zfand2b
Vertical activity count, locomotor time 2	12.25	2	0	0	0	1e+00	Zdhhc1 Zfand2b
Weight adjusted by age	9.91	1	0	0	0	1e+00	Zfand2b
Seeking ratio, delayed vs. immediate footshock	6.97	2	0	0	0	1e+00	Tead1 Zfand2b
Locomotion in novel chamber post-restriction	14.04	1	0	0	0	1e+00	Zfand2b
Progressive ratio	22.47	1	0	0	0	1e+00	Zdhhc1
Food seeking constrained by brief footshock	14.98	1	0	0	0	1e+00	Zfand2b
Seeking ratio, punishment vs. effort	9.83	1	0	0	0	1e+00	Zdhhc1
Run reversals in cocaine runway, females	36.45	1	1	33.3	0	1e+00	Zfand2b
Latency to leave start box in cocaine runway	34.23	1	1	33.3	0	1e+00	Zfand2b
Latency to leave start box in cocaine runway, F	20.83	2	1	33.3	0	1e+00	Zdhhc1 Zfand2b
Latency to leave start box in cocaine runway, M	42.07	1	1	33.3	0	1e+00	Zdhhc1

Associations by panel

Tissue	RNA modality	# hits	% hits/tests	Avg chisq
Adipose	alternative polyA	0	0	0.96
Adipose	alternative TSS	0	0	0.98
Adipose	gene expression	0	0	0.99
Adipose	isoform ratio	0	0	1
Adipose	intron excision ratio	0	0	1
Adipose	mRNA stability	0	0	1.02
BLA	alternative polyA	0	0	1.07
BLA	alternative TSS	0	0	1.03
BLA	gene expression	0	0	1.03
BLA	isoform ratio	0	0	1.04
BLA	intron excision ratio	0	0	0.99
BLA	mRNA stability	0	0	0.99
Brain	alternative polyA	0	0	1.08
Brain	alternative TSS	0	0	1.02
Brain	gene expression	0	0	1
Brain	isoform ratio	0	0	1.04
Brain	intron excision ratio	0	0	0.98
Brain	mRNA stability	0	0	1.02
Eye	alternative polyA	0	0	1.17
Eye	alternative TSS	0	0	1.2
Eye	gene expression	0	0	1.08
Eye	isoform ratio	0	0	0.96
Eye	intron excision ratio	0	0	0.98
Eye	mRNA stability	0	0	1.01
IL	alternative polyA	0	0	0.98
IL	alternative TSS	0	0	1.08
IL	gene expression	0	0	1.03
IL	isoform ratio	0	0	0.97
IL	intron excision ratio	0	0	1
IL	mRNA stability	0	0	1.05
LHb	alternative polyA	0	0	1.02
LHb	alternative TSS	0	0	1.11
LHb	gene expression	0	0	1
LHb	isoform ratio	0	0	1.07
LHb	intron excision ratio	0	0	1.01
LHb	mRNA stability	0	0	1.05
Liver	alternative polyA	0	0	1.03
Liver	alternative TSS	0	0	1.06
Liver	gene expression	0	0	1.03
Liver	isoform ratio	0	0	1.01
Liver	intron excision ratio	0	0	1.03
Liver	mRNA stability	0	0	1
NAcc	alternative polyA	0	0	1.05
NAcc	alternative TSS	1	0	1.01
NAcc	gene expression	0	0	1.01
NAcc	isoform ratio	0	0	1
NAcc	intron excision ratio	0	0	1.01
NAcc	mRNA stability	1	0	1.05
OFC	alternative polyA	0	0	1.01
OFC	alternative TSS	0	0	1.09
OFC	gene expression	0	0	1
OFC	isoform ratio	0	0	0.97
OFC	intron excision ratio	0	0	0.93
OFC	mRNA stability	0	0	0.99
PL	alternative polyA	0	0	1.03
PL	alternative TSS	0	0	0.99
PL	gene expression	0	0	1.01
PL	isoform ratio	0	0	1.01
PL	intron excision ratio	1	0	1.04
PL	mRNA stability	0	0	1.03
pVTA	alternative polyA	0	0	1.12
pVTA	alternative TSS	0	0	1.07
pVTA	gene expression	0	0	1.02
pVTA	isoform ratio	0	0	1.04
pVTA	intron excision ratio	0	0	1.06
pVTA	mRNA stability	0	0	1.1
RMTg	alternative polyA	0	0	0.99
RMTg	alternative TSS	0	0	0.93
RMTg	gene expression	0	0	1.02
RMTg	isoform ratio	0	0	0.97
RMTg	intron excision ratio	0	0	1.08
RMTg	mRNA stability	0	0	1.16