Hub : Traits

Incentive Sensitization - Responses

Tags: Behavior · Motivation · Progressive ratio

Project: p50_paul_meyer_2020

5 loci · 5 genes with independent associations · 6 total associated genes

Significant Loci

#	Chr	Start pos	End pos	# assoc genes	# joint models	Best TWAS P	Best GWAS P	Cond GWAS P	Joint genes
1	chr1	88613126	89913275	1	1	4.99e-08	6.95e-03	9.46e-02	Zfp575
2	chr5	118282290	119677504	1	1	5.40e-08	4.93e-01	1.00e+00	Atg4c
3	chr7	92127461	93066096	1	1	4.13e-13	6.50e-01	1.00e+00	Ndufb9
4	chr9	83390749	84777604	2	1	0.00e+00	2.78e-01	1.00e+00	Retreg2
5	chr17	61510864	62906219	1	1	3.95e-11	1.67e-02	1.00e+00	Ccny

Pleiotropic Associations

Trait	Chi2 ratio	# genes+	# genes++	% genes++	Corr	Corr P	Genes
BMI with tail	1925.3	2	2	40	0	1.00e+00	Ndufb9 Retreg2
BMI without tail	36014.74	3	3	60	-1	1.73e-04	Ccny Ndufb9 Retreg2
Body weight	8.89	2	1	20	0	1.00e+00	Ndufb9 Retreg2
Epididymis fat weight	27131.26	3	2	40	-1	3.26e-04	Ccny Ndufb9 Retreg2
Glucose	795.03	3	1	20	0	1.00e+00	Atg4c Ndufb9 Retreg2
Heart weight	4511.78	3	2	40	0	1.00e+00	Ccny Ndufb9 Retreg2
Left kidney weight	35320.16	3	2	40	1	5.61e-06	Ccny Ndufb9 Retreg2
Right kidney weight	29220.22	3	3	60	1	8.48e-06	Ccny Ndufb9 Retreg2
Tail length	30717.51	2	2	40	0	1.00e+00	Ccny Retreg2
Length with tail	2050.83	2	2	40	0	1.00e+00	Ndufb9 Retreg2
Length without tail	25870.23	4	2	40	1	1.23e-07	Ccny Ndufb9 Retreg2 Zfp575
Liver weight, left	4845.91	3	2	40	0	1.00e+00	Ccny Ndufb9 Retreg2
Liver weight, right	88.25	3	1	20	0	1.00e+00	Ccny Ndufb9 Retreg2
Parametrial fat weight	208.83	2	1	20	0	1.00e+00	Ccny Retreg2
Retroperitoneal fat weight	5356.91	2	2	40	0	1.00e+00	Atg4c Retreg2
Intraocular pressure	20040.92	1	1	20	0	1.00e+00	Retreg2
Extensor digitorum longus weight	4682.69	1	1	20	0	1.00e+00	Retreg2
Soleus weight	40.94	3	1	20	0	1.00e+00	Ccny Ndufb9 Retreg2
Tibialis anterior weight	4881.94	1	1	20	0	1.00e+00	Retreg2
Tibia length	1631.46	2	1	20	0	1.00e+00	Ndufb9 Retreg2
Number of licking bursts	52378.83	2	1	20	0	1.00e+00	Ccny Retreg2
Food consumed during 24 hour testing period	35405.76	2	1	20	0	1.00e+00	Ccny Retreg2
Times rat made contact with spout	158.46	2	1	20	0	1.00e+00	Ndufb9 Retreg2
Mean time between licks in bursts	49879.82	3	1	20	-1	2.40e-06	Ccny Ndufb9 Retreg2
Mean num. licks in bursts	47539.71	2	1	20	0	1.00e+00	Ccny Retreg2
Std. dev. time between licks in bursts	47023.26	1	1	20	0	1.00e+00	Retreg2
Water consumed over 24 hours	34477.35	2	1	20	0	1.00e+00	Ccny Retreg2
Patch foraging indifference point 0 sec	57503.47	2	1	20	0	1.00e+00	Atg4c Retreg2
Patch foraging indifference point AUC	33302.97	3	2	40	1	3.53e-04	Ccny Ndufb9 Retreg2
Indifference point function ln k	35530	3	3	60	-1	3.23e-04	Ccny Ndufb9 Retreg2
Indifference point function log k	35530	3	3	60	-1	3.23e-04	Ccny Ndufb9 Retreg2
Patch foraging total patch changes 0 sec	40090.28	2	1	20	0	1.00e+00	Atg4c Retreg2
Patch foraging total patch changes 12 sec	2766.66	4	3	60	-1	1.93e-03	Atg4c Ccny Ndufb9 Retreg2
Patch foraging total patch changes 18 sec	23558.39	4	1	20	-1	6.46e-09	Atg4c Ccny Ndufb9 Retreg2
Patch foraging total patch changes 24 sec	41791.78	3	3	60	-1	3.33e-05	Ccny Ndufb9 Retreg2
Patch foraging total patch changes 6 sec	8182.17	4	3	60	-1	2.87e-04	Atg4c Ccny Ndufb9 Retreg2
Patch foraging time to switch 0 sec	52215.04	2	2	40	0	1.00e+00	Ndufb9 Retreg2
Patch foraging water rate 0 sec	49608.69	2	1	20	0	1.00e+00	Ndufb9 Retreg2
Patch foraging water rate 12 sec	53974.31	2	2	40	0	1.00e+00	Ccny Retreg2
Patch foraging water rate 18 sec	25824.08	3	1	20	1	2.36e-06	Ccny Ndufb9 Retreg2
Patch foraging water rate 24 sec	2357.13	2	2	40	0	1.00e+00	Ccny Retreg2
Patch foraging water rate 6 sec	1023.52	4	3	60	1	4.27e-03	Atg4c Ccny Ndufb9 Retreg2
Locomotor activity	35.04	2	1	20	0	1.00e+00	Ccny Retreg2
Locomotor testing distance	22396.59	3	2	40	1	9.56e-04	Ccny Ndufb9 Retreg2
Locomotor testing rearing	50814.7	2	1	20	0	1.00e+00	Ndufb9 Retreg2
Light reinforcement 1	38840.3	3	2	40	1	2.65e-04	Atg4c Ccny Retreg2
Light reinforcement 2	27014.42	3	2	40	1	3.78e-04	Ccny Ndufb9 Retreg2
Reaction time number correct	38379.7	3	3	60	1	1.98e-05	Ccny Ndufb9 Retreg2
Reaction time mean minus median	51458.48	3	1	20	-1	4.46e-05	Ccny Ndufb9 Retreg2
Reaction time mean minus median AUC	69474.35	2	2	40	0	1.00e+00	Ndufb9 Retreg2
Reaction time num false alarms	28557.11	2	2	40	0	1.00e+00	Ccny Retreg2
Reaction time num false alarms AUC	35512.89	2	2	40	0	1.00e+00	Ccny Retreg2
Reaction time trials correct on left	38379.7	3	3	60	1	1.98e-05	Ccny Ndufb9 Retreg2
Reaction time trials on left	37513.48	3	3	60	1	3.56e-05	Ccny Ndufb9 Retreg2
Reaction time mean	23601.36	3	1	20	-1	1.35e-04	Atg4c Ccny Retreg2
Reaction time mean AUC	28341.95	3	1	20	-1	1.21e-04	Atg4c Ccny Retreg2
Median of all reaction times	10477.75	2	1	20	0	1.00e+00	Atg4c Retreg2
Reaction time omissions	11426.44	2	1	20	0	1.00e+00	Ndufb9 Retreg2
Reaction time false alarm rate	448.49	2	1	20	0	1.00e+00	Ndufb9 Retreg2
Reaction time premature initiation rate	18442.81	2	1	20	0	1.00e+00	Ccny Retreg2
Reaction time premature initiations	46245.52	2	1	20	0	1.00e+00	Ccny Retreg2
Std. dev. reaction times	49836.07	2	1	20	0	1.00e+00	Ndufb9 Retreg2
Reaction time trials completed	37513.48	3	3	60	1	3.56e-05	Ccny Ndufb9 Retreg2
Reaction time trials AUC	37939.65	3	2	40	1	4.32e-05	Ccny Ndufb9 Retreg2
Social response proportion	17659.31	2	1	20	0	1.00e+00	Atg4c Retreg2
Social responses	1906.34	3	2	40	0	1.00e+00	Ccny Ndufb9 Retreg2
Social time	22121.54	2	1	20	0	1.00e+00	Ccny Retreg2
Conditioned locomotion	3044.63	2	1	20	0	1.00e+00	Ccny Retreg2
Cocaine response after cond. corrected	16463.61	3	1	20	-1	3.51e-04	Atg4c Ccny Retreg2
Cocaine response after cond. not corrected	16069.67	3	1	20	-1	2.66e-04	Atg4c Ccny Retreg2
Cocaine response before conditioning	1409.02	2	1	20	0	1.00e+00	Ccny Retreg2
Saline control response	6484.47	1	1	20	0	1.00e+00	Retreg2
Condit. Reinf. active minus inactive responses	53410.48	1	1	20	0	1.00e+00	Retreg2
Condit. Reinf. active-inactive response ratio	45793.79	2	1	20	0	1.00e+00	Ndufb9 Retreg2
Condit. Reinf. active responses	9691.24	1	1	20	0	1.00e+00	Retreg2
Condit. Reinf. inactive responses	21056.03	2	1	20	0	1.00e+00	Ccny Retreg2
Condit. Reinf. lever presses	7939.8	2	1	20	0	1.00e+00	Ndufb9 Retreg2
Condit. Reinf. lever reinforcers received	2000.77	1	1	20	0	1.00e+00	Retreg2
Pavlov. Cond. lever latency	10912.53	1	1	20	0	1.00e+00	Retreg2
Pavlov. Cond. magazine entry latency	24714.14	2	1	20	0	1.00e+00	Ccny Retreg2
Pavlov. Cond. change in total contacts	38264.3	2	1	20	0	1.00e+00	Ndufb9 Retreg2
Pavlov. Cond. index score	23998.4	2	1	20	0	1.00e+00	Ccny Retreg2
Pavlov. Cond. latency score	29242.48	2	1	20	0	1.00e+00	Ccny Retreg2
Pavlov. Cond. lever contacts	22069.78	1	1	20	0	1.00e+00	Retreg2
Pavlov. Cond. magazine entry number	8389.95	2	1	20	0	1.00e+00	Atg4c Retreg2
Pavlov. Cond. intertrial magazine entries	52471.02	1	1	20	0	1.00e+00	Retreg2
Pavlov. Cond. lever-magazine prob. diff.	22438.69	2	1	20	0	1.00e+00	Ccny Retreg2
Pavlov. Cond. response bias	5169.79	1	1	20	0	1.00e+00	Retreg2
Conditioned reinforcement - actives	47885.1	3	3	60	-1	1.28e-04	Ccny Ndufb9 Retreg2
Conditioned reinforcement - inactives	31020.31	4	4	80	-1	5.84e-06	Atg4c Ccny Ndufb9 Retreg2
Conditioned locomotion	13843.65	3	3	60	0	1.00e+00	Ccny Ndufb9 Retreg2
Intermittent access intake day 1-15 change	52657.18	3	2	40	-1	2.46e-05	Atg4c Ccny Retreg2
Intermittent access intake escalation	69852.9	2	1	20	0	1.00e+00	Atg4c Retreg2
Intermittent access intake escalation 2	54050.4	2	2	40	0	1.00e+00	Ccny Retreg2
Intermitt. access day 1 inactive lever presses	59141	3	1	20	-1	3.90e-05	Ccny Ndufb9 Retreg2
Intermitt. access day 15 inactive lever presses	69437.6	2	2	40	0	1.00e+00	Ndufb9 Retreg2
Intermitt. access escalation Index	46255.05	3	1	20	1	2.67e-06	Ccny Ndufb9 Retreg2
Intermittent access day 1 total infusions	38887.92	3	1	20	1	5.86e-05	Atg4c Ccny Retreg2
Intermittent access day 15 total infusions	32877.32	3	1	20	-1	7.28e-05	Ccny Retreg2 Zfp575
Intermittent access terminal intake (last 3 days)	27738.75	3	1	20	0	1.00e+00	Ccny Retreg2 Zfp575
Intermittent access total infusions	235.12	3	1	20	0	1.00e+00	Ccny Retreg2 Zfp575
Intermittent access day 1 locomotion	34835.54	2	2	40	0	1.00e+00	Ccny Retreg2
Intermittent access day 15 total locomotion	44477.15	3	2	40	-1	1.30e-04	Atg4c Ccny Retreg2
Intermittent access total locomotion	243.63	3	1	20	0	1.00e+00	Ndufb9 Retreg2 Zfp575
Intermittent access standard deviation	67324.56	2	2	40	0	1.00e+00	Ccny Retreg2
Cocaine induced anxiety	40090.29	3	3	60	1	3.32e-04	Ccny Ndufb9 Retreg2
Post-drug Anxiety	5125.99	3	2	40	1	1.45e-03	Ndufb9 Retreg2 Zfp575
Baseline Anxiety	25921.06	3	3	60	-1	1.40e-03	Ccny Ndufb9 Retreg2
Lifetime Intake	2295.1	3	2	40	0	1.00e+00	Ccny Retreg2 Zfp575
Incentive Sensitization - Breakpoint	23812.11	5	5	100	1	1.45e-11	Atg4c Ccny Ndufb9 Retreg2 Zfp575
Progressive ratio test 1 active lever presses	24987.93	3	2	40	-1	3.70e-04	Ccny Ndufb9 Retreg2
Progressive ratio test 1 breakpoint	24081.17	3	2	40	-1	3.58e-04	Ccny Ndufb9 Retreg2
Progressive ratio test 1 inactive lever presses	30229.91	4	3	60	-1	3.77e-06	Atg4c Ccny Ndufb9 Retreg2
Progressive ratio test 2 active lever presses	9549.75	5	2	40	1	2.53e-08	Atg4c Ccny Ndufb9 Retreg2 Zfp575
Progressive ratio test 2 breakpoint	7013.85	4	2	40	1	6.91e-06	Atg4c Ccny Retreg2 Zfp575
Progressive ratio test 2 inactive lever presses	41034.49	3	2	40	-1	1.10e-04	Ccny Ndufb9 Retreg2
Total sessions with >9 infusions	2016.45	4	2	40	0.99	6.06e-03	Atg4c Ccny Retreg2 Zfp575
Short access day 1 total inactive lever presses	22890.27	4	4	80	1	4.56e-06	Ccny Ndufb9 Retreg2 Zfp575
Short access day 10 total inactive lever presses	72422.55	2	2	40	0	1.00e+00	Ccny Retreg2
Short access day 1 total infusions	27935.8	3	2	40	1	7.06e-04	Ccny Retreg2 Zfp575
Short access day 10 total infusions	15265.56	4	2	40	1	2.02e-06	Atg4c Ccny Ndufb9 Retreg2
Short access total infusions	17026.24	2	2	40	0	1.00e+00	Ccny Retreg2
Short access day 1 locomotion	16830.87	4	3	60	-1	1.02e-05	Ccny Ndufb9 Retreg2 Zfp575
Short access day 10 total locomotion	45407	3	2	40	-1	8.56e-05	Atg4c Ccny Retreg2
Short access total locomotion	22760	2	1	20	0	1.00e+00	Ndufb9 Retreg2
Compulsive drug intake	13095.06	4	1	20	1	8.27e-06	Ccny Ndufb9 Retreg2 Zfp575
One hour access (0.3 mA shock)	2437.63	4	3	60	-1	7.11e-04	Ccny Ndufb9 Retreg2 Zfp575
One hour access (shock baseline)	35072.75	3	1	20	-1	7.87e-05	Ccny Retreg2 Zfp575
Number of responses in last shaping day	12858.59	3	2	40	-1	1.29e-03	Ccny Retreg2 Zfp575
Context. condit. distance diff. score	970.59	1	1	20	0	1.00e+00	Retreg2
Locomotion velocity, session 1	7315.11	2	1	20	0	1.00e+00	Ndufb9 Retreg2
Locomotion distance, session 1	2213.01	2	1	20	0	1.00e+00	Ccny Retreg2
Locomotion velocity, session 2	4683.52	2	1	20	0	1.00e+00	Atg4c Retreg2
Locomotion distance, session 2	1206.44	2	1	20	0	1.00e+00	Ccny Retreg2
Locomotion velocity, session 3	2332.53	1	1	20	0	1.00e+00	Retreg2
Locomotion distance, session 3	16615.78	1	1	20	0	1.00e+00	Retreg2
Stereotopy head waving bouts, day 3	5866.4	1	1	20	0	1.00e+00	Retreg2
Stereotopy head waving duration, day 3	12131.92	1	1	20	0	1.00e+00	Retreg2
Locomotion velocity, session 7	1310.17	1	1	20	0	1.00e+00	Retreg2
Locomotion distance, session 7	1879.14	2	1	20	0	1.00e+00	Ndufb9 Retreg2
Stereotopy head waving bouts, day 7	5257.18	2	2	40	0	1.00e+00	Ndufb9 Retreg2
Stereotopy head waving duration, day 7	4446.48	2	2	40	0	1.00e+00	Ndufb9 Retreg2
Locomotion velocity, session 8	950.4	2	1	20	0	1.00e+00	Ccny Retreg2
Locomotion distance, session 8	673.32	1	1	20	0	1.00e+00	Retreg2
Degree of sensitization distance	15309.16	1	1	20	0	1.00e+00	Retreg2
Degree of sensitization stereotypy	4256.13	2	1	20	0	1.00e+00	Ndufb9 Retreg2
Condit. Reinf. active minus inactive responses	1382.49	3	1	20	0	1.00e+00	Atg4c Ccny Retreg2
Condit. Reinf. active-inactive response ratio	555.67	2	1	20	0	1.00e+00	Atg4c Retreg2
Condit. Reinf. active responses	3898.02	3	1	20	0	1.00e+00	Atg4c Ccny Retreg2
Condit. Reinf. inactive responses	9694.1	2	1	20	0	1.00e+00	Ndufb9 Retreg2
Incentive salience index mean	4935.93	3	1	20	0	1.00e+00	Atg4c Ccny Retreg2
Condit. Reinf. lever presses	21433.81	1	1	20	0	1.00e+00	Retreg2
Time in familiar zone, hab. session 1	20942.04	1	1	20	0	1.00e+00	Retreg2
Time in novel zone, hab. session 1	11846.13	2	1	20	0	1.00e+00	Atg4c Retreg2
Total zone transitions, hab. session 1	916.07	2	1	20	0	1.00e+00	Ndufb9 Retreg2
Total locomotion distance, hab. session 1	849.35	2	1	20	0	1.00e+00	Ccny Retreg2
Locomotion velocity, hab. session 1	571.33	2	1	20	0	1.00e+00	Ccny Retreg2
Time in familiar zone, hab. session 2	11692.92	1	1	20	0	1.00e+00	Retreg2
Time in novel zone, hab. session 2	8313.4	2	1	20	0	1.00e+00	Atg4c Retreg2
Total zone transitions, hab. session 2	143.96	2	1	20	0	1.00e+00	Ndufb9 Retreg2
Total locomotion distance, hab. session 2	51.92	2	1	20	0	1.00e+00	Ccny Retreg2
Locomotion velocity, hab. session 2	77.91	2	1	20	0	1.00e+00	Ccny Retreg2
Novel to familiar place preference ratio	13883.42	3	1	20	-1	2.15e-04	Atg4c Ccny Retreg2
Novelty place preference	18134.07	3	1	20	0	1.00e+00	Atg4c Ccny Retreg2
Time in novel zone, NPP test	20429.42	2	1	20	0	1.00e+00	Atg4c Retreg2
Total zone transitions, NPP test	4127.68	2	2	40	0	1.00e+00	Ndufb9 Retreg2
Total locomotion distance, NPP test	3566.83	2	2	40	0	1.00e+00	Ccny Retreg2
Locomotion velocity, NPP test	2031.76	2	2	40	0	1.00e+00	Ccny Retreg2
Pavlov. Cond. lever latency	1101.84	2	1	20	0	1.00e+00	Atg4c Retreg2
Pavlov. Cond. magazine entry latency	8.04	1	0	0	0	1.00e+00	Ccny
Pavlov. Cond. change in total contacts	2273.55	2	1	20	0	1.00e+00	Ccny Retreg2
Pavlov. Cond. index score	888.06	2	1	20	0	1.00e+00	Atg4c Retreg2
Pavlov. Cond. latency score	1841.19	1	1	20	0	1.00e+00	Retreg2
Pavlov. Cond. lever contacts	1017.05	3	1	20	0	1.00e+00	Atg4c Ndufb9 Retreg2
Pavlov. Cond. magazine entry number	1086.53	2	1	20	0	1.00e+00	Ccny Retreg2
Pavlov. Cond. intertrial magazine entries	269.44	2	1	20	0	1.00e+00	Ndufb9 Retreg2
Pavlov. Cond. lever-magazine prob. diff.	973.09	2	1	20	0	1.00e+00	Atg4c Retreg2
Pavlov. Cond. response bias	1308.04	2	1	20	0	1.00e+00	Atg4c Retreg2
Bone: apparent density	11138.75	2	1	20	0	1.00e+00	Ndufb9 Retreg2
Bone surface	25125.6	1	1	20	0	1.00e+00	Retreg2
Bone volume	33831.7	1	1	20	0	1.00e+00	Retreg2
Bone: connectivity density	3557.17	2	1	20	0	1.00e+00	Ndufb9 Retreg2
Bone: cortical apparent density	15092.86	3	1	20	0	1.00e+00	Ccny Ndufb9 Retreg2
Bone: cortical area	9468.26	2	1	20	0	1.00e+00	Ndufb9 Retreg2
Bone: cortical porosity	923.93	2	1	20	0	1.00e+00	Ndufb9 Retreg2
Bone: cortical porosity	2407.81	2	1	20	0	1.00e+00	Ndufb9 Retreg2
Bone: cortical thickness	817.52	2	1	20	0	1.00e+00	Ndufb9 Retreg2
Bone: cortical thickness	6100.69	2	1	20	0	1.00e+00	Ndufb9 Retreg2
Bone: cortical tissue density	16155.62	3	1	20	0	1.00e+00	Ccny Ndufb9 Retreg2
Bone: elastic displacement	14817.48	1	1	20	0	1.00e+00	Retreg2
Bone: elastic work	1494.59	1	1	20	0	1.00e+00	Retreg2
Bone: endosteal estimation	17631.97	2	1	20	0	1.00e+00	Ndufb9 Retreg2
Bone: endosteal perimeter	22350.62	1	1	20	0	1.00e+00	Retreg2
Bone: final force	7031.22	1	1	20	0	1.00e+00	Retreg2
Bone: final moment	1042.62	1	1	20	0	1.00e+00	Retreg2
Bone: marrow area	18537.3	2	1	20	0	1.00e+00	Ndufb9 Retreg2
Bone: maximum diameter	12203.48	2	1	20	0	1.00e+00	Ndufb9 Retreg2
Bone: maximum force	34553.99	1	1	20	0	1.00e+00	Retreg2
Bone: maximum moment	24715.64	1	1	20	0	1.00e+00	Retreg2
Bone: minimum diameter	17196.64	1	1	20	0	1.00e+00	Retreg2
Bone: periosteal estimation	38190.5	1	1	20	0	1.00e+00	Retreg2
Bone: periosteal perimeter	43183.28	1	1	20	0	1.00e+00	Retreg2
Bone: post-yield work	50847.58	1	1	20	0	1.00e+00	Retreg2
Bone: stiffness	35564.91	1	1	20	0	1.00e+00	Retreg2
Bone: tissue strength	12264.67	1	1	20	0	1.00e+00	Retreg2
Bone: trabecular number	20584.56	2	2	40	0	1.00e+00	Ndufb9 Retreg2
Bone: trabecular spacing	15655.12	2	2	40	0	1.00e+00	Ndufb9 Retreg2
Bone: trabecular thickness	33264.33	1	1	20	0	1.00e+00	Retreg2
Bone: trabecular tissue density	17885.93	3	3	60	0	1.00e+00	Ccny Ndufb9 Retreg2
Breakpoint value in progressive ratio session	37484.23	2	1	20	0	1.00e+00	Ccny Retreg2
Distance traveled before self-admin	22353.61	5	3	60	-1	1.14e-07	Atg4c Ccny Ndufb9 Retreg2 Zfp575
Distance traveled after self-admin	25246.42	4	3	60	-1	2.08e-04	Atg4c Ccny Retreg2 Zfp575
Delta time in closed arm before/after self-admin	522.76	4	2	40	-0.85	1.53e-01	Atg4c Ccny Ndufb9 Retreg2
Delta time in open arm before/after self-admin	13728.65	3	2	40	-1	1.26e-03	Atg4c Ccny Retreg2
Diff in mean of infusions in LGA sessions	27131.82	3	2	40	1	3.33e-05	Atg4c Ndufb9 Retreg2
Extinction: sum of active levers before priming	22946.4	3	3	60	-1	4.68e-04	Ccny Ndufb9 Retreg2
Active lever presses in extinction session 6	1673.08	2	2	40	0	1.00e+00	Ccny Retreg2
Delta distance traveled before/after self-admin	3156.2	3	3	60	0.99	7.96e-03	Ccny Ndufb9 Retreg2
Delta ambulatory time before/after self-admin	19227.54	4	2	40	1	1.51e-05	Atg4c Ccny Ndufb9 Retreg2
Time in closed arm before self-admin	22074.73	3	2	40	1	3.18e-04	Atg4c Ccny Retreg2
Time in closed arm after self-admin	9901.19	2	2	40	0	1.00e+00	Ccny Retreg2
Time in open arm before self-admin	5806.61	5	3	60	1	2.73e-05	Atg4c Ccny Ndufb9 Retreg2 Zfp575
Time in open arm after self-admin	669.46	3	3	60	0	1.00e+00	Ccny Ndufb9 Retreg2
Sum of active levers in priming session hrs 5-6	1945.79	2	1	20	0	1.00e+00	Ndufb9 Retreg2
Time to tail flick, vehicle, before self-admin	12969.21	3	2	40	-1	3.35e-03	Ccny Ndufb9 Retreg2
Time to tail flick, vehicle, after self-admin	23671.91	4	2	40	-1	7.27e-06	Ccny Ndufb9 Retreg2 Zfp575
Time to tail flick, test, before self-admin	8218.7	4	2	40	1	1.37e-03	Atg4c Ccny Ndufb9 Retreg2
Time to tail flick, test, after self-admin	2022.59	3	3	60	0	1.00e+00	Ccny Ndufb9 Retreg2
Delta time to tail flick, vehicle, before/after SA	12304.44	2	2	40	0	1.00e+00	Ccny Retreg2
Delta time to tail flick, test, before/after SA	18952.76	3	1	20	0	1.00e+00	Ccny Ndufb9 Retreg2
Ambulatory time before self-admin	42793.01	3	3	60	-1	5.10e-05	Atg4c Ccny Retreg2
Ambulatory time after self-admin	29453.28	3	3	60	0	1.00e+00	Atg4c Ccny Retreg2
Total heroin consumption	370.51	3	2	40	0	1.00e+00	Atg4c Ccny Retreg2
Area under the delay curve	20413.22	3	2	40	1	2.63e-04	Atg4c Ccny Retreg2
Delay disc. indifference point, 0s delay	4741.82	2	1	20	0	1.00e+00	Ccny Retreg2
Delay disc. indifference point, 16s delay	18726.93	3	3	60	1	5.22e-04	Atg4c Ccny Retreg2
Delay disc. indifference point, 2s delay	282.83	3	1	20	0	1.00e+00	Atg4c Ccny Retreg2
Delay disc. indifference point, 24s delay	25014.94	3	2	40	1	3.42e-04	Atg4c Ccny Retreg2
Delay disc. indifference point, 4s delay	661.39	4	3	60	0.98	2.43e-02	Atg4c Ccny Ndufb9 Retreg2
Delay disc. indifference point, 8s delay	33815.67	2	1	20	0	1.00e+00	Atg4c Retreg2
Delay discount exponential model param	15063.57	3	2	40	-1	3.05e-04	Atg4c Ccny Retreg2
Delay discount hyperbolic model param	15250.3	2	2	40	0	1.00e+00	Atg4c Retreg2
Fecal boli incidents, locomotor time 1	37546.11	3	1	20	1	1.49e-07	Atg4c Ccny Retreg2
Change in fecal boli incidents, locomotor task	7889.79	3	3	60	0	1.00e+00	Ccny Ndufb9 Retreg2
Time >=10cm from walls, locomotor time 1	9866.97	4	2	40	1	2.14e-05	Atg4c Ccny Ndufb9 Retreg2
Bouts of movement, locomotor time 1	20842.46	2	2	40	0	1.00e+00	Ccny Retreg2
Total resting periods, locomotor time 1	5936.78	2	2	40	0	1.00e+00	Ccny Retreg2
Rest time, locomotor task time 1	18996.61	3	1	20	-1	2.94e-04	Ccny Ndufb9 Retreg2
Distance moved, locomotor task time 1	39837.96	3	3	60	1	2.83e-04	Ccny Ndufb9 Retreg2
Vertical activity count, locomotor time 1	73027.69	2	1	20	0	1.00e+00	Retreg2 Zfp575
Time >=10cm from walls, locomotor time 2	53999.89	2	1	20	0	1.00e+00	Ccny Retreg2
Bouts of movement, locomotor time 2	58114.39	2	2	40	0	1.00e+00	Ccny Retreg2
Total resting periods, locomotor time 2	63372.9	2	2	40	0	1.00e+00	Ccny Retreg2
Rest time, locomotor task time 2	16764.22	4	2	40	1	5.39e-06	Atg4c Ccny Ndufb9 Retreg2
Distance moved, locomotor task time 2	11481.53	3	2	40	0	1.00e+00	Atg4c Ccny Retreg2
Vertical activity count, locomotor time 2	34622.46	3	2	40	1	9.02e-05	Atg4c Ccny Retreg2
Weight adjusted by age	32418.6	4	3	60	-1	9.74e-06	Ccny Ndufb9 Retreg2 Zfp575
Seeking ratio, delayed vs. immediate footshock	16476.57	3	2	40	0	1.00e+00	Ccny Retreg2 Zfp575
Locomotion in novel chamber	5467.09	3	3	60	0	1.00e+00	Ccny Ndufb9 Retreg2
Locomotion in novel chamber post-restriction	38665.63	3	1	20	1	6.92e-05	Ccny Ndufb9 Retreg2
Progressive ratio	31596.76	4	3	60	1	6.93e-06	Atg4c Ccny Ndufb9 Retreg2
Food seeking constrained by brief footshock	1841.77	4	1	20	1	2.25e-03	Atg4c Ndufb9 Retreg2 Zfp575
Seeking ratio, punishment vs. effort	29579.13	3	3	60	-1	2.00e-04	Ccny Ndufb9 Retreg2
Run reversals in cocaine runway, females	18598.36	2	1	20	0	1.00e+00	Ccny Retreg2
Run reversals in cocaine runway, males	7496.92	3	2	40	-1	1.83e-03	Ccny Ndufb9 Retreg2
Latency to leave start box in cocaine runway	29317.55	2	2	40	0	1.00e+00	Ccny Retreg2
Latency to leave start box in cocaine runway, F	14201.52	2	2	40	0	1.00e+00	Ndufb9 Retreg2
Latency to leave start box in cocaine runway, M	1844.99	4	2	40	0.99	5.96e-03	Ccny Ndufb9 Retreg2 Zfp575
Co content in liver	4721.74	1	1	20	0	1.00e+00	Retreg2
Cu content in liver	89.33	2	1	20	0	1.00e+00	Ndufb9 Retreg2
Fe content in liver	5656.2	1	1	20	0	1.00e+00	Retreg2
K content in liver	6593.53	1	1	20	0	1.00e+00	Retreg2
Mg content in liver	24493.99	1	1	20	0	1.00e+00	Retreg2
Mn content in liver	2219.37	2	2	40	0	1.00e+00	Ndufb9 Retreg2
Na content in liver	8325.4	2	1	20	0	1.00e+00	Ndufb9 Retreg2
Rb content in liver	241.33	2	2	40	0	1.00e+00	Ndufb9 Retreg2
Se content in liver	8.64	1	0	0	0	1.00e+00	Ndufb9
Zn content in liver	7891.81	2	2	40	0	1.00e+00	Ndufb9 Retreg2

Associations by panel

Tissue	RNA modality	# hits	% hits/tests	Avg chisq
Adipose	alternative polyA	0	0	1.03
Adipose	alternative TSS	0	0	0.96
Adipose	gene expression	0	0	1
Adipose	isoform ratio	0	0	0.98
Adipose	intron excision ratio	0	0	0.97
Adipose	mRNA stability	1	0	1.04
BLA	alternative polyA	0	0	1.09
BLA	alternative TSS	0	0	1.04
BLA	gene expression	0	0	1.04
BLA	isoform ratio	0	0	1.03
BLA	intron excision ratio	0	0	0.96
BLA	mRNA stability	0	0	1.02
Brain	alternative polyA	0	0	1.06
Brain	alternative TSS	0	0	1.04
Brain	gene expression	0	0	1.03
Brain	isoform ratio	0	0	1.05
Brain	intron excision ratio	0	0	0.99
Brain	mRNA stability	0	0	1.03
Eye	alternative polyA	0	0	0.92
Eye	alternative TSS	0	0	1.15
Eye	gene expression	0	0	1.08
Eye	isoform ratio	0	0	1.06
Eye	intron excision ratio	0	0	1.05
Eye	mRNA stability	0	0	1.07
IC	alternative polyA	0	0	1.06
IC	alternative TSS	0	0	1.11
IC	gene expression	0	0	1.03
IC	isoform ratio	0	0	1.03
IC	intron excision ratio	1	0	0.96
IC	mRNA stability	0	0	1.03
IL	alternative polyA	0	0	1.11
IL	alternative TSS	0	0	1.06
IL	gene expression	0	0	0.99
IL	isoform ratio	0	0	1.01
IL	intron excision ratio	0	0	0.89
IL	mRNA stability	0	0	1.07
LHb	alternative polyA	0	0	1.13
LHb	alternative TSS	0	0	1.08
LHb	gene expression	0	0	0.99
LHb	isoform ratio	0	0	1.03
LHb	intron excision ratio	0	0	0.88
LHb	mRNA stability	0	0	1.03
Liver	alternative polyA	0	0	1.04
Liver	alternative TSS	0	0	1.01
Liver	gene expression	0	0	1.02
Liver	isoform ratio	0	0	1.05
Liver	intron excision ratio	0	0	0.98
Liver	mRNA stability	0	0	1.02
NAcc	alternative polyA	2	0.1	127.38
NAcc	alternative TSS	0	0	1.03
NAcc	gene expression	0	0	1.02
NAcc	isoform ratio	0	0	1
NAcc	intron excision ratio	0	0	0.99
NAcc	mRNA stability	0	0	1.06
OFC	alternative polyA	0	0	1.09
OFC	alternative TSS	0	0	1.08
OFC	gene expression	0	0	1.01
OFC	isoform ratio	0	0	1.04
OFC	intron excision ratio	0	0	0.81
OFC	mRNA stability	0	0	1.09
PL	alternative polyA	0	0	1.09
PL	alternative TSS	0	0	1.02
PL	gene expression	0	0	1
PL	isoform ratio	0	0	1
PL	intron excision ratio	0	0	0.98
PL	mRNA stability	1	0	1.05
pVTA	alternative polyA	0	0	1.08
pVTA	alternative TSS	0	0	1.05
pVTA	gene expression	1	0	1.03
pVTA	isoform ratio	0	0	1.03
pVTA	intron excision ratio	0	0	0.96
pVTA	mRNA stability	0	0	1.08
RMTg	alternative polyA	0	0	0.95
RMTg	alternative TSS	0	0	1.2
RMTg	gene expression	0	0	1
RMTg	isoform ratio	0	0	1.02
RMTg	intron excision ratio	0	0	0.95
RMTg	mRNA stability	0	0	1.12