Hub : Genes

Xndc1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Liver gene expression Xndc1 0.07 0.05 4.8e-06 0.04 0.03 0.04 0.04 6.8e-05 1.9e-04 6.5e-05 7.5e-05
2 LHb gene expression Xndc1 0.28 0.17 3.3e-03 0.04 0.04 0.01 0.03 4.2e-02 3.3e-02 1.6e-01 8.4e-02
3 NAcc gene expression Xndc1 0.09 0.06 1.9e-08 0.07 0.07 0.07 0.07 8.5e-09 8.1e-09 1.1e-08 1.0e-08
4 PL gene expression Xndc1 0.17 0.12 3.8e-11 0.11 0.1 0.1 0.1 1.2e-11 5.5e-11 4.4e-11 1.5e-11
5 Brain mRNA stability Xndc1 0.08 0.06 1.1e-05 0.06 0.06 0.06 0.06 1.6e-06 6.7e-06 3.3e-06 3.9e-06
6 IL gene expression Xndc1 0.24 0.15 6.4e-04 0.15 0.13 0.12 0.14 1.9e-04 5.1e-04 9.9e-04 2.7e-04
7 NAcc intron excision ratio chr1_156450846_156452614 0.13 0.11 9.8e-09 0.08 0.07 0.07 0.07 1.2e-09 8.6e-09 1.7e-08 1.3e-08
8 Liver intron excision ratio chr1_156450846_156452614 0.05 0.04 2.3e-04 0.03 0.03 0.03 0.03 7.3e-04 6.2e-04 6.0e-04 3.0e-04
9 BLA gene expression Xndc1 0.17 0.11 2.4e-06 0.11 0.1 0.09 0.11 1.6e-06 6.6e-06 1.4e-05 1.6e-06
10 pVTA intron excision ratio chr1_156450846_156452614 0.1 0.07 2.0e-03 0.06 0.04 0.05 0.06 9.0e-04 5.4e-03 3.0e-03 1.2e-03
11 PL intron excision ratio chr1_156450846_156452614 0.07 0.05 1.5e-06 0.06 0.05 0.04 0.05 3.3e-07 2.9e-06 1.7e-05 2.1e-06
12 Adipose gene expression Xndc1 0.05 0.04 2.8e-04 0.03 0.02 0.02 0.02 4.3e-04 1.3e-03 9.7e-04 1.7e-03
13 Brain intron excision ratio chr1_156450846_156452614 0.12 0.07 6.0e-08 0.08 0.08 0.07 0.08 4.0e-08 6.7e-08 2.0e-07 4.7e-08
14 pVTA gene expression Xndc1 0.19 0.12 5.2e-05 0.12 0.09 0.08 0.1 4.7e-06 7.4e-05 3.5e-04 3.4e-05
15 Brain gene expression Xndc1 0.14 0.09 4.9e-10 0.1 0.1 0.09 0.1 6.3e-10 8.1e-10 1.6e-08 2.6e-09

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15
Bone: apparent density0.10.10.20.5-0.4-0.40.3-0.20.4-0.40.40.2-0.2-0.20.3-0.30.30.3
Area under the delay curve0.10.10.50.7-0.00.1-0.30.3-0.30.3-0.3-0.40.40.4-0.20.3-0.4-0.4
BMI with tail1.96.28.51.0-2.3-2.42.9-2.72.8-2.82.82.4-2.3-2.32.5-2.52.52.5
BMI without tail0.10.21.3-1.10.50.40.0-0.00.1-0.10.1-0.30.40.4-0.20.3-0.4-0.3
Body weight0.31.31.7-1.01.31.2-1.01.1-1.01.0-1.0-1.21.21.2-1.21.3-1.2-1.3
Weight adjusted by age0.60.71.6-1.31.11.0-0.90.6-0.80.8-0.8-0.70.70.7-0.90.6-0.6-0.7
Bone surface0.71.31.5-1.11.21.2-1.11.2-1.11.1-1.1-1.21.21.2-1.11.1-1.1-1.1
Bone volume0.61.01.2-0.81.01.0-1.01.1-1.01.0-1.0-1.11.11.1-1.01.0-1.0-1.0
Breakpoint value in progressive ratio session1.01.12.30.3-1.0-1.01.0-1.01.0-1.01.01.4-1.2-1.21.5-1.01.10.9
Number of licking bursts1.01.25.22.3-1.5-1.40.8-0.80.8-0.80.80.9-0.9-0.90.9-0.80.80.8
Context. condit. distance diff. score0.40.55.3-2.31.00.8-0.40.3-0.30.3-0.30.0-0.0-0.0-0.10.1-0.1-0.0
Locomotion velocity, session 12.52.63.00.8-1.6-1.61.7-1.71.6-1.61.61.7-1.7-1.71.7-1.71.71.7
Locomotion distance, session 10.70.91.3-0.6-0.6-0.71.0-1.01.0-1.01.01.0-1.0-1.01.2-1.01.01.0
Locomotion velocity, session 21.01.21.8-0.1-0.9-1.01.1-1.11.1-1.11.11.1-1.1-1.11.3-1.11.11.1
Locomotion distance, session 20.91.31.7-0.4-0.9-1.01.2-1.21.2-1.21.21.2-1.2-1.21.3-1.21.21.2
Locomotion velocity, session 30.20.21.0-1.00.50.5-0.40.4-0.40.4-0.4-0.30.30.3-0.10.2-0.2-0.3
Locomotion distance, session 30.10.11.2-1.10.30.2-0.10.0-0.10.1-0.10.1-0.1-0.10.3-0.10.10.1
Stereotopy head waving bouts, day 30.60.71.00.20.70.7-0.80.8-0.80.8-0.8-1.01.01.0-1.00.9-0.9-1.0
Stereotopy head waving duration, day 30.00.00.1-0.30.0-0.00.3-0.30.3-0.30.30.0-0.0-0.0-0.00.0-0.0-0.0
Locomotion velocity, session 71.01.11.60.3-1.0-1.01.0-1.01.1-1.11.11.1-1.1-1.11.3-1.11.11.1
Locomotion distance, session 70.00.00.20.4-0.2-0.2-0.00.1-0.00.0-0.00.1-0.1-0.10.2-0.10.10.1
Stereotopy head waving bouts, day 70.70.84.0-2.01.21.1-0.60.6-0.60.6-0.6-0.70.70.7-0.50.7-0.7-0.7
Stereotopy head waving duration, day 70.50.64.3-2.11.10.9-0.40.4-0.40.4-0.4-0.50.50.5-0.40.5-0.5-0.5
Locomotion velocity, session 80.40.52.4-1.60.90.8-0.70.6-0.70.7-0.7-0.30.30.3-0.40.3-0.3-0.3
Locomotion distance, session 80.30.44.6-2.10.50.30.1-0.20.1-0.10.10.4-0.4-0.40.4-0.30.30.4
Degree of sensitization distance0.60.60.90.40.50.6-0.90.9-0.90.9-0.9-0.90.90.9-0.90.8-0.8-0.9
Degree of sensitization stereotypy1.31.48.3-2.91.61.5-0.90.9-0.90.9-0.9-0.80.80.8-0.60.8-0.8-0.8
Conditioned locomotion0.30.40.70.40.30.4-0.80.7-0.80.8-0.8-0.50.50.5-0.50.5-0.5-0.5
Cocaine response after cond. corrected0.40.41.81.4-0.9-0.80.6-0.50.6-0.60.60.4-0.4-0.40.4-0.50.50.4
Cocaine response after cond. not corrected1.01.11.31.0-1.1-1.11.1-1.01.1-1.11.11.0-1.0-1.00.9-1.01.01.0
Cocaine response before conditioning0.60.71.2-1.1-0.3-0.40.9-0.80.9-0.90.90.9-0.9-0.90.9-0.90.90.9
Saline control response3.95.06.0-2.12.42.4-2.22.3-2.32.3-2.3-2.22.22.2-2.22.2-2.2-2.2
Bone: connectivity density1.21.82.20.4-1.3-1.31.4-1.31.4-1.41.41.4-1.4-1.41.5-1.51.51.5
Bone: cortical apparent density0.10.21.61.3-0.2-0.1-0.20.3-0.20.2-0.2-0.30.30.3-0.30.4-0.4-0.4
Bone: cortical area0.50.81.3-0.70.90.9-1.01.1-0.90.9-0.9-0.80.80.8-0.80.8-0.8-0.8
Bone: cortical porosity0.30.30.4-0.40.60.6-0.60.6-0.70.7-0.7-0.50.50.5-0.40.5-0.5-0.5
Bone: cortical porosity0.30.40.5-0.40.60.6-0.70.6-0.70.7-0.7-0.60.60.6-0.60.5-0.5-0.6
Bone: cortical thickness0.50.81.00.6-0.9-0.90.9-0.70.9-0.90.90.9-0.9-0.91.0-0.90.90.9
Bone: cortical thickness0.00.00.0-0.10.10.1-0.10.1-0.10.1-0.10.0-0.0-0.0-0.00.0-0.00.0
Bone: cortical tissue density0.10.21.61.3-0.3-0.1-0.20.3-0.10.1-0.1-0.30.30.3-0.30.4-0.4-0.4
Condit. Reinf. active minus inactive responses2.32.62.9-0.91.61.7-1.61.6-1.61.6-1.6-1.71.71.7-1.71.7-1.7-1.7
Condit. Reinf. active-inactive response ratio4.54.85.4-1.22.22.2-2.22.2-2.22.2-2.2-2.32.32.3-2.32.3-2.3-2.3
Condit. Reinf. active responses1.21.51.8-0.21.11.1-1.21.2-1.21.2-1.2-1.41.41.4-1.41.3-1.3-1.3
Condit. Reinf. inactive responses0.20.30.70.8-0.7-0.60.5-0.50.5-0.50.50.4-0.4-0.40.4-0.50.50.5
Incentive salience index mean1.41.72.1-0.51.21.3-1.21.3-1.21.2-1.2-1.51.51.5-1.41.4-1.4-1.4
Condit. Reinf. lever presses0.00.00.10.20.00.0-0.00.0-0.00.0-0.0-0.30.30.3-0.20.2-0.2-0.2
Condit. Reinf. active minus inactive responses5.06.113.1-3.63.02.8-2.42.2-2.42.4-2.4-2.32.32.3-2.22.2-2.2-2.2
Condit. Reinf. active-inactive response ratio0.40.42.2-1.50.90.8-0.50.5-0.50.5-0.5-0.50.50.5-0.50.5-0.5-0.5
Condit. Reinf. active responses7.19.918.0-4.23.73.5-3.02.9-3.03.0-3.0-2.92.92.9-2.92.9-2.9-2.9
Condit. Reinf. inactive responses5.06.18.0-2.82.82.7-2.42.4-2.42.4-2.4-2.42.42.4-2.42.4-2.4-2.4
Condit. Reinf. lever presses5.37.326.9-5.23.53.2-2.32.2-2.32.3-2.3-2.22.22.2-2.22.2-2.2-2.1
Condit. Reinf. lever reinforcers received7.09.819.3-4.43.73.6-3.02.9-3.03.0-3.0-2.92.92.9-2.92.8-2.8-2.8
Conditioned reinforcement - actives0.10.10.3-0.5-0.0-0.00.2-0.10.2-0.20.20.4-0.0-0.00.5-0.40.30.3
Conditioned reinforcement - inactives0.30.40.80.70.20.3-0.60.6-0.60.6-0.6-0.70.90.9-0.70.4-0.4-0.6
Conditioned locomotion0.30.41.2-1.1-0.1-0.30.6-0.70.6-0.60.60.6-0.5-0.50.7-0.70.80.6
Patch foraging indifference point 0 sec0.50.83.7-1.91.21.0-0.50.5-0.50.5-0.5-0.70.70.7-0.80.9-0.8-0.8
Patch foraging indifference point AUC0.50.60.8-0.70.90.9-0.80.6-0.80.8-0.8-0.80.70.7-0.90.9-0.8-0.8
Delay disc. indifference point, 0s delay0.10.20.5-0.70.50.4-0.30.3-0.30.3-0.3-0.40.40.4-0.30.4-0.5-0.4
Delay disc. indifference point, 16s delay0.80.81.40.50.50.6-0.90.9-0.90.9-0.9-1.11.21.2-0.81.0-1.0-1.1
Delay disc. indifference point, 2s delay1.11.21.6-0.71.11.1-1.11.1-1.11.1-1.1-1.11.21.2-1.01.1-1.2-1.2
Delay disc. indifference point, 24s delay0.20.21.61.3-0.3-0.2-0.20.2-0.20.2-0.2-0.30.40.4-0.20.3-0.3-0.4
Delay disc. indifference point, 4s delay1.31.31.5-0.91.21.2-1.11.1-1.11.1-1.1-1.21.21.2-1.11.1-1.2-1.2
Delay disc. indifference point, 8s delay0.00.00.30.6-0.3-0.30.0-0.00.0-0.00.00.0-0.1-0.10.4-0.10.0-0.0
Indifference point function ln k0.10.10.2-0.2-0.2-0.20.4-0.30.4-0.40.40.2-0.3-0.30.4-0.40.30.4
Indifference point function log k0.10.10.2-0.2-0.2-0.20.4-0.30.4-0.40.40.2-0.3-0.30.4-0.40.30.4
Patch foraging total patch changes 0 sec0.30.42.8-1.70.90.8-0.30.2-0.30.3-0.3-0.50.40.4-0.60.6-0.6-0.6
Patch foraging total patch changes 12 sec1.21.51.9-1.31.41.3-1.31.0-1.21.2-1.2-1.21.01.0-1.31.3-1.2-1.2
Patch foraging total patch changes 18 sec0.40.51.7-1.30.90.9-0.60.5-0.60.6-0.7-0.50.50.5-0.70.8-0.7-0.7
Patch foraging total patch changes 24 sec1.31.62.0-1.31.41.3-1.20.9-1.21.2-1.2-1.21.21.2-1.41.3-1.3-1.2
Patch foraging total patch changes 6 sec0.20.30.9-0.90.60.5-0.00.0-0.00.0-0.0-0.60.50.5-0.80.6-0.5-0.5
Patch foraging time to switch 0 sec0.81.36.22.5-1.6-1.40.8-0.70.8-0.80.80.8-0.8-0.80.9-0.90.90.9
Patch foraging water rate 0 sec0.60.94.5-2.11.41.2-0.70.7-0.70.7-0.7-0.60.60.6-0.70.8-0.8-0.7
Patch foraging water rate 12 sec0.91.42.1-1.5-0.4-0.61.2-1.31.2-1.21.21.2-1.2-1.21.2-1.21.21.2
Patch foraging water rate 18 sec0.30.44.6-2.10.80.6-0.20.1-0.10.1-0.10.00.10.10.10.0-0.1-0.1
Patch foraging water rate 24 sec0.71.01.3-0.3-0.7-0.81.1-1.11.1-1.11.11.1-0.9-0.91.1-1.01.10.9
Patch foraging water rate 6 sec0.50.71.2-0.8-0.3-0.50.9-0.80.8-0.80.91.1-1.0-1.00.9-0.90.90.8
Seeking ratio, delayed vs. immediate footshock1.61.83.21.8-1.6-1.51.2-1.31.1-1.11.11.4-1.3-1.31.3-1.31.41.3
Distance traveled before self-admin1.01.11.71.0-1.1-1.10.9-1.00.9-0.90.91.3-1.0-1.00.9-1.21.21.2
Distance traveled after self-admin0.60.71.5-0.3-0.5-0.60.7-0.70.6-0.60.60.9-1.0-1.01.0-1.21.21.2
Extensor digitorum longus weight0.00.20.30.5-0.6-0.50.3-0.50.4-0.40.40.3-0.4-0.40.4-0.50.50.4
Bone: elastic displacement2.73.13.71.6-1.9-1.91.8-1.81.7-1.71.71.8-1.8-1.81.7-1.71.71.7
Bone: elastic work5.57.27.92.1-2.8-2.82.7-2.72.7-2.72.72.7-2.7-2.72.7-2.72.72.7
Bone: endosteal estimation2.14.55.5-1.82.22.2-2.32.2-2.32.3-2.3-2.02.02.0-2.01.9-1.9-2.0
Bone: endosteal perimeter1.94.05.1-2.02.22.2-2.12.2-2.12.1-2.1-1.91.91.9-1.91.8-1.8-1.9
Epididymis fat weight0.00.10.60.7-0.3-0.20.20.00.2-0.20.20.10.10.10.10.00.1-0.1
Delta time in closed arm before/after self-admin0.60.61.10.80.30.4-0.70.7-0.70.7-0.7-0.70.80.8-0.81.0-1.0-0.9
Delta time in open arm before/after self-admin2.62.53.4-1.81.81.7-1.51.5-1.51.5-1.5-1.91.81.8-1.81.2-1.1-1.6
Diff in mean of infusions in LGA sessions0.80.91.61.30.30.5-0.90.9-0.90.9-0.9-1.11.01.0-1.01.1-0.9-1.2
Delay discount exponential model param0.10.10.7-0.80.20.10.1-0.10.1-0.10.10.2-0.3-0.3-0.0-0.10.20.2
Extinction: sum of active levers before priming0.10.10.30.4-0.4-0.40.3-0.30.3-0.30.30.3-0.4-0.40.4-0.50.30.4
Active lever presses in extinction session 60.30.30.9-1.0-0.1-0.20.6-0.70.6-0.60.60.3-0.4-0.40.4-0.30.40.4
Bone: final force1.22.02.50.31.01.1-1.51.6-1.51.5-1.5-1.61.61.6-1.51.5-1.5-1.5
Bone: final moment1.21.92.40.01.11.2-1.51.5-1.41.4-1.4-1.51.51.5-1.51.5-1.5-1.5
Food consumed during 24 hour testing period0.30.33.4-1.80.80.7-0.30.2-0.20.2-0.2-0.20.20.2-0.20.3-0.3-0.3
Glucose0.71.01.4-0.0-0.8-0.90.9-1.00.9-0.90.91.2-1.2-1.21.2-1.21.21.2
Heart weight0.40.51.7-1.31.00.9-0.50.5-0.60.6-0.6-0.80.70.7-0.90.4-0.3-0.5
Delay discount hyperbolic model param0.10.10.4-0.60.0-0.10.3-0.30.3-0.30.30.4-0.4-0.40.2-0.30.40.4
Intermittent access intake day 1-15 change1.61.62.3-0.5-0.8-0.91.5-1.41.5-1.51.51.1-1.2-1.21.1-1.31.41.3
Intermittent access intake escalation1.91.92.6-0.3-0.9-1.01.6-1.51.6-1.61.61.2-1.3-1.31.2-1.51.61.5
Intermittent access intake escalation 20.80.81.10.3-0.8-0.81.0-0.91.0-1.01.00.8-0.9-0.90.8-1.01.01.1
Intermitt. access day 1 inactive lever presses0.30.32.11.5-0.1-0.0-0.40.3-0.40.4-0.4-0.50.50.5-0.60.6-0.5-0.5
Intermitt. access day 15 inactive lever presses0.10.10.3-0.40.40.30.10.10.1-0.10.1-0.30.30.3-0.50.2-0.1-0.2
Intermitt. access escalation Index0.30.30.6-0.10.40.5-0.30.6-0.30.3-0.3-0.60.60.6-0.60.8-0.7-0.6
Intermittent access day 1 total infusions1.11.21.8-1.31.31.3-1.31.3-1.31.3-1.3-0.80.80.8-0.70.9-1.0-1.0
Intermittent access day 15 total infusions0.10.10.9-0.90.50.4-0.10.2-0.10.1-0.10.0-0.0-0.00.1-0.10.10.1
Intermittent access terminal intake (last 3 days)0.20.20.9-1.00.60.6-0.40.5-0.40.4-0.4-0.10.00.00.10.1-0.2-0.2
Intermittent access total infusions0.30.30.7-0.90.70.7-0.60.7-0.60.6-0.6-0.20.10.1-0.10.4-0.4-0.3
Intermittent access day 1 locomotion0.30.30.4-0.00.40.4-0.60.6-0.60.6-0.6-0.50.50.5-0.40.5-0.5-0.5
Intermittent access day 15 total locomotion0.30.30.5-0.6-0.2-0.30.6-0.70.6-0.60.60.5-0.6-0.60.5-0.50.60.5
Intermittent access total locomotion0.10.10.5-0.70.40.3-0.20.1-0.20.2-0.2-0.10.10.1-0.00.1-0.1-0.1
Intermittent access standard deviation0.80.91.10.5-0.9-0.91.0-0.91.0-1.01.00.8-0.9-0.90.8-1.01.11.0
Left kidney weight0.30.92.6-1.61.31.2-0.70.8-0.70.7-0.7-0.90.90.9-1.00.8-0.6-0.9
Right kidney weight0.31.01.6-1.11.21.1-0.80.8-0.70.7-0.7-1.11.11.1-1.30.9-0.7-1.0
Cocaine induced anxiety0.40.44.82.2-0.7-0.6-0.00.0-0.00.0-0.0-0.30.40.4-0.30.2-0.1-0.2
Post-drug Anxiety1.71.82.60.41.01.1-1.41.5-1.41.4-1.4-1.41.41.4-1.51.6-1.6-1.4
Baseline Anxiety2.12.23.6-1.91.91.8-1.51.5-1.51.5-1.5-1.01.01.0-1.31.5-1.5-1.4
Tail length8.425.429.6-4.25.45.4-5.14.9-5.05.0-5.0-4.94.94.9-4.95.2-5.1-5.2
Length with tail4.717.319.5-2.94.44.4-4.44.2-4.34.3-4.3-4.14.04.0-4.34.2-4.1-4.3
Length without tail0.00.00.30.6-0.1-0.1-0.20.3-0.20.2-0.20.1-0.1-0.1-0.1-0.10.30.1
Times rat made contact with spout0.10.10.30.50.10.1-0.30.3-0.30.3-0.3-0.40.40.4-0.30.4-0.4-0.4
Lifetime Intake0.20.31.4-1.20.80.7-0.50.7-0.50.5-0.5-0.10.10.10.00.2-0.3-0.3
Liver weight, left1.32.03.51.00.81.0-1.91.8-1.81.8-1.8-1.31.31.3-1.31.2-1.2-1.2
Liver weight, right2.84.76.40.71.51.7-2.52.4-2.52.5-2.5-2.22.22.2-2.22.2-2.2-2.2
Locomotor activity0.00.10.7-0.80.20.10.0-0.20.2-0.20.20.1-0.2-0.20.2-0.20.10.2
Locomotor testing distance0.20.43.5-1.90.90.7-0.40.3-0.30.3-0.4-0.20.10.1-0.10.2-0.2-0.2
Locomotor testing rearing0.71.01.8-1.31.21.2-1.11.1-1.11.1-1.2-0.70.70.7-0.71.0-0.9-1.0
Locomotion in novel chamber2.63.24.10.9-1.6-1.61.9-1.82.0-2.02.01.9-1.9-1.91.5-1.81.71.9
Locomotion in novel chamber post-restriction0.20.30.7-0.8-0.1-0.20.6-0.50.5-0.50.50.4-0.4-0.40.5-0.70.60.6
Fecal boli incidents, locomotor time 10.20.21.61.3-0.7-0.60.1-0.20.1-0.10.10.3-0.3-0.30.5-0.10.20.3
Change in fecal boli incidents, locomotor task0.10.10.1-0.30.20.2-0.20.1-0.20.2-0.2-0.30.40.4-0.30.3-0.3-0.4
Time >=10cm from walls, locomotor time 10.60.70.9-0.90.90.9-0.70.7-0.70.7-0.7-0.70.90.9-0.80.9-1.0-0.8
Bouts of movement, locomotor time 11.01.12.3-0.20.90.9-1.00.8-0.90.9-0.9-1.31.51.5-1.20.9-1.1-1.0
Total resting periods, locomotor time 10.20.20.80.20.20.2-0.30.2-0.30.3-0.3-0.60.90.9-0.50.3-0.5-0.4
Rest time, locomotor task time 10.40.50.7-0.20.60.7-0.80.8-0.80.8-0.8-0.50.70.7-0.40.8-0.8-0.8
Distance moved, locomotor task time 10.10.10.10.1-0.2-0.20.3-0.30.3-0.30.30.3-0.3-0.30.2-0.20.30.3
Vertical activity count, locomotor time 10.10.10.10.10.10.1-0.30.1-0.30.3-0.3-0.10.30.3-0.20.2-0.3-0.2
Time >=10cm from walls, locomotor time 23.84.15.0-1.92.22.2-2.02.0-2.12.1-2.1-2.02.02.0-2.01.9-1.9-1.7
Bouts of movement, locomotor time 23.53.84.7-0.51.71.8-2.22.0-2.12.1-2.1-2.02.12.1-1.81.9-2.0-2.0
Total resting periods, locomotor time 22.22.43.1-0.11.21.3-1.81.6-1.81.8-1.8-1.61.71.7-1.41.6-1.6-1.6
Rest time, locomotor task time 21.31.53.31.8-1.5-1.41.0-1.01.0-1.01.01.2-1.2-1.21.4-1.01.00.9
Distance moved, locomotor task time 21.21.33.5-1.91.51.4-1.01.0-1.01.0-1.0-1.01.01.0-1.01.0-1.1-0.9
Vertical activity count, locomotor time 21.41.62.0-0.81.21.2-1.41.2-1.41.4-1.4-1.11.21.2-1.11.3-1.4-1.2
Light reinforcement 12.64.76.32.2-2.5-2.52.1-2.32.2-2.22.12.1-2.0-2.02.1-2.02.02.1
Light reinforcement 25.06.78.00.6-2.3-2.42.6-2.72.7-2.72.72.8-2.8-2.82.8-2.72.82.7
Bone: marrow area1.94.15.1-1.62.12.1-2.22.1-2.32.3-2.3-1.91.91.9-2.01.9-1.9-1.9
Bone: maximum diameter2.03.64.8-2.12.22.1-1.92.1-2.02.0-2.0-1.81.81.8-1.81.7-1.7-1.7
Bone: maximum force0.81.42.0-0.10.91.0-1.31.4-1.31.3-1.3-1.21.21.2-1.11.2-1.2-1.2
Bone: maximum moment0.61.01.5-0.30.80.9-1.11.2-1.11.1-1.1-1.01.01.0-1.01.0-1.0-1.0
Mean time between licks in bursts8.612.114.2-3.03.83.7-3.43.4-3.43.4-3.4-3.53.53.5-3.53.4-3.4-3.4
Mean num. licks in bursts1.11.34.2-2.01.51.4-0.90.9-0.90.9-0.9-1.01.01.0-1.01.0-1.0-1.0
Cd content in liver0.10.10.70.8-0.4-0.3-0.00.0-0.00.0-0.00.4-0.4-0.40.4-0.30.30.3
Co content in liver5.26.16.6-1.82.62.6-2.52.5-2.52.5-2.5-2.52.52.5-2.52.5-2.5-2.5
Cu content in liver2.63.23.4-1.31.81.9-1.81.8-1.81.8-1.8-1.81.81.8-1.81.8-1.8-1.8
Fe content in liver0.70.91.10.10.70.8-1.01.0-1.01.0-1.0-1.01.01.0-1.01.0-1.0-1.0
K content in liver0.10.10.90.9-0.5-0.40.3-0.30.3-0.30.30.1-0.1-0.10.1-0.10.10.1
Mg content in liver0.00.00.10.0-0.2-0.20.3-0.30.3-0.30.30.1-0.1-0.10.1-0.20.20.2
Mn content in liver2.62.93.71.8-1.9-1.91.6-1.61.6-1.61.61.7-1.7-1.71.7-1.71.71.8
Na content in liver0.00.00.2-0.40.20.2-0.00.0-0.00.0-0.0-0.10.00.0-0.1-0.10.1-0.0
Rb content in liver0.81.01.2-0.81.11.1-1.01.0-1.01.0-1.0-0.91.01.0-0.91.0-1.0-1.0
Se content in liver1.31.56.22.5-1.7-1.50.9-0.90.9-0.90.91.0-1.1-1.11.0-1.11.11.1
Sr content in liver2.11.92.4-0.1-1.1-1.21.5-1.51.5-1.51.51.4-1.4-1.41.4-1.41.41.4
Zn content in liver0.30.33.3-1.80.50.30.2-0.20.2-0.20.20.3-0.2-0.20.3-0.10.10.2
Bone: minimum diameter2.03.75.0-1.11.91.9-2.12.2-2.12.1-2.1-1.91.91.9-1.81.9-1.9-1.9
Time in familiar zone, hab. session 10.10.10.4-0.60.30.3-0.30.2-0.30.3-0.3-0.10.10.1-0.10.1-0.1-0.1
Time in novel zone, hab. session 10.20.20.30.60.20.2-0.30.4-0.30.3-0.3-0.50.50.5-0.40.5-0.5-0.5
Total zone transitions, hab. session 10.20.30.4-0.4-0.3-0.40.6-0.50.5-0.50.50.6-0.6-0.60.6-0.60.60.6
Total locomotion distance, hab. session 10.81.21.50.10.80.9-1.01.0-1.01.0-1.0-1.21.21.2-1.21.2-1.2-1.2
Locomotion velocity, hab. session 10.40.60.80.20.50.6-0.70.7-0.70.7-0.7-0.90.90.9-0.90.9-0.9-0.9
Time in familiar zone, hab. session 23.33.44.1-1.92.02.0-1.81.8-1.81.8-1.8-1.81.81.8-1.81.8-1.8-1.8
Time in novel zone, hab. session 24.34.34.71.4-2.0-2.02.1-2.12.2-2.22.22.1-2.1-2.12.1-2.12.12.1
Total zone transitions, hab. session 20.20.33.5-1.90.70.50.1-0.10.1-0.10.10.0-0.0-0.0-0.2-0.10.10.0
Total locomotion distance, hab. session 21.21.62.2-1.01.31.3-1.21.2-1.21.2-1.2-1.31.31.3-1.51.3-1.3-1.3
Locomotion velocity, hab. session 21.31.72.3-0.91.31.3-1.31.2-1.31.3-1.3-1.31.31.3-1.51.3-1.3-1.3
Novel to familiar place preference ratio2.93.03.7-0.21.61.7-1.71.7-1.71.7-1.7-1.91.91.9-1.91.9-1.9-1.9
Novelty place preference2.72.73.3-0.31.51.6-1.61.7-1.61.6-1.6-1.81.81.8-1.81.8-1.8-1.8
Time in novel zone, NPP test3.13.23.8-0.51.71.8-1.81.8-1.81.8-1.8-1.91.91.9-2.01.9-1.9-1.9
Total zone transitions, NPP test1.52.12.4-0.1-1.2-1.31.6-1.61.5-1.51.51.6-1.6-1.61.5-1.51.51.5
Total locomotion distance, NPP test0.20.30.50.5-0.6-0.60.7-0.70.7-0.70.70.5-0.5-0.50.5-0.50.50.5
Locomotion velocity, NPP test0.50.81.00.8-1.0-1.01.0-1.01.0-1.01.00.8-0.8-0.80.8-0.80.80.8
Intraocular pressure0.40.50.90.2-0.6-0.70.9-0.80.9-0.90.90.6-0.6-0.60.6-0.70.80.7
Delta distance traveled before/after self-admin2.32.43.9-2.01.81.8-1.61.7-1.61.6-1.6-1.51.31.3-1.21.4-1.3-1.4
Delta ambulatory time before/after self-admin1.11.32.9-1.71.41.3-1.11.2-1.11.1-1.1-1.10.80.8-0.81.0-0.9-1.0
Parametrial fat weight1.32.63.41.2-1.6-1.61.5-1.51.5-1.51.51.6-1.7-1.71.7-1.71.71.8
Pavlov. Cond. lever latency0.91.11.31.0-1.1-1.11.0-1.11.0-1.01.01.1-1.1-1.11.0-1.01.01.0
Pavlov. Cond. magazine entry latency1.11.55.1-2.31.61.5-1.11.1-1.11.1-1.1-0.90.90.9-0.90.9-0.9-0.9
Pavlov. Cond. change in total contacts2.52.62.8-1.31.71.7-1.71.7-1.71.7-1.7-1.61.61.6-1.61.6-1.6-1.6
Pavlov. Cond. index score1.21.53.7-1.91.51.4-1.21.2-1.21.2-1.2-1.11.11.1-1.01.1-1.1-1.1
Pavlov. Cond. latency score1.31.73.2-1.81.51.5-1.31.3-1.31.3-1.3-1.21.21.2-1.11.2-1.2-1.2
Pavlov. Cond. lever contacts0.60.71.0-1.01.00.9-0.90.9-0.80.8-0.8-0.80.80.8-0.80.8-0.8-0.8
Pavlov. Cond. magazine entry number0.91.24.42.1-1.4-1.31.0-1.01.0-1.01.00.8-0.8-0.80.9-0.80.80.8
Pavlov. Cond. intertrial magazine entries0.10.11.21.1-0.5-0.40.1-0.20.1-0.10.10.1-0.1-0.10.1-0.10.10.1
Pavlov. Cond. lever-magazine prob. diff.1.01.23.0-1.71.31.3-1.11.1-1.01.0-1.0-1.01.01.0-0.91.0-1.0-1.0
Pavlov. Cond. response bias0.50.61.6-1.31.00.9-0.80.8-0.80.8-0.8-0.60.60.6-0.70.6-0.6-0.7
Pavlov. Cond. lever latency4.05.428.75.4-3.2-2.91.7-1.81.8-1.81.81.6-1.6-1.61.6-1.61.61.6
Pavlov. Cond. magazine entry latency1.01.24.3-2.1-0.0-0.31.1-0.91.0-1.01.01.1-1.1-1.11.1-1.01.01.0
Pavlov. Cond. change in total contacts2.94.025.3-5.02.82.5-1.31.3-1.31.3-1.3-1.31.31.3-1.31.3-1.3-1.3
Pavlov. Cond. index score2.02.520.1-4.52.31.9-0.91.0-0.90.9-0.9-0.80.80.8-0.80.8-0.8-0.8
Pavlov. Cond. latency score1.41.717.1-4.11.91.5-0.50.6-0.60.6-0.6-0.40.40.4-0.40.4-0.4-0.4
Pavlov. Cond. lever contacts4.56.229.3-5.43.43.1-1.92.0-1.91.9-1.9-1.91.91.9-1.91.9-1.9-1.8
Pavlov. Cond. magazine entry number0.60.89.53.1-0.9-0.6-0.30.2-0.30.3-0.3-0.30.30.3-0.30.3-0.3-0.3
Pavlov. Cond. intertrial magazine entries2.22.83.3-0.41.51.6-1.71.7-1.71.7-1.7-1.81.81.8-1.81.8-1.8-1.8
Pavlov. Cond. lever-magazine prob. diff.2.02.619.3-4.42.32.0-0.91.1-1.01.0-1.0-0.80.80.8-0.90.9-0.9-0.8
Pavlov. Cond. response bias3.64.829.4-5.43.12.7-1.51.6-1.51.5-1.5-1.41.41.4-1.51.4-1.4-1.4
Time in closed arm before self-admin0.30.42.6-1.60.30.10.4-0.40.4-0.40.40.3-0.4-0.40.5-0.60.60.5
Time in closed arm after self-admin0.10.10.50.7-0.4-0.40.2-0.20.2-0.20.20.3-0.2-0.20.2-0.10.10.1
Time in open arm before self-admin2.42.68.62.9-2.1-1.91.4-1.51.4-1.41.41.6-1.5-1.51.2-1.21.11.4
Time in open arm after self-admin0.30.40.70.00.50.5-0.60.6-0.60.6-0.6-0.70.70.7-0.90.6-0.5-0.6
Bone: periosteal estimation1.32.73.5-1.41.71.7-1.81.9-1.81.8-1.8-1.51.51.5-1.51.5-1.5-1.5
Bone: periosteal perimeter1.01.72.4-1.51.51.5-1.31.5-1.41.4-1.4-1.11.11.1-1.11.1-1.1-1.1
Bone: post-yield work0.10.10.4-0.60.40.3-0.40.4-0.40.4-0.4-0.10.10.1-0.00.1-0.1-0.1
Progressive ratio test 1 active lever presses0.00.00.0-0.20.10.1-0.10.2-0.10.1-0.10.10.00.00.2-0.1-0.0-0.1
Progressive ratio test 1 breakpoint0.10.10.1-0.20.30.3-0.30.4-0.30.3-0.3-0.00.10.10.10.1-0.2-0.2
Progressive ratio test 1 inactive lever presses0.00.00.1-0.10.20.2-0.20.2-0.20.2-0.20.1-0.0-0.00.0-0.0-0.0-0.0
Progressive ratio test 2 active lever presses0.50.50.9-0.60.80.8-0.81.0-0.80.8-0.8-0.60.70.7-0.30.5-0.6-0.5
Progressive ratio test 2 breakpoint0.60.71.1-0.70.90.9-0.91.0-0.90.9-0.9-0.70.80.8-0.50.6-0.7-0.6
Progressive ratio test 2 inactive lever presses0.00.00.1-0.30.20.2-0.10.2-0.10.1-0.10.10.10.10.2-0.1-0.00.0
Incentive Sensitization - Responses1.01.01.3-1.01.11.1-1.11.1-1.11.1-1.1-0.90.90.9-0.70.9-0.9-0.9
Incentive Sensitization - Breakpoint0.50.50.7-0.90.80.8-0.80.8-0.80.8-0.7-0.60.60.6-0.40.6-0.5-0.6
Sum of active levers in priming session hrs 5-60.30.20.7-0.2-0.2-0.30.4-0.40.4-0.40.40.6-0.8-0.80.6-0.50.50.6
Progressive ratio0.50.61.20.0-0.6-0.70.9-1.00.9-0.90.90.4-0.4-0.40.5-1.01.11.0
Food seeking constrained by brief footshock1.62.02.7-1.61.61.6-1.11.4-1.21.2-1.2-1.61.41.4-1.61.4-1.4-1.2
Seeking ratio, punishment vs. effort1.82.23.5-1.11.51.5-1.41.7-1.51.5-1.5-1.11.21.2-1.21.7-1.9-1.7
Retroperitoneal fat weight0.10.32.81.7-0.4-0.2-0.30.3-0.20.2-0.2-0.20.40.4-0.20.3-0.2-0.2
Reaction time number correct0.20.30.60.1-0.5-0.50.6-0.60.6-0.60.60.8-0.6-0.60.7-0.50.50.5
Reaction time mean minus median0.30.40.7-0.70.80.7-0.70.9-0.70.7-0.7-0.70.70.7-0.50.5-0.5-0.6
Reaction time mean minus median AUC0.20.20.5-0.70.60.6-0.50.7-0.50.5-0.5-0.50.50.5-0.20.4-0.4-0.4
Reaction time num false alarms0.20.33.51.9-0.5-0.3-0.10.3-0.10.1-0.1-0.30.30.3-0.40.4-0.2-0.3
Reaction time num false alarms AUC0.20.33.41.8-0.7-0.50.10.10.1-0.10.10.00.00.0-0.10.10.0-0.0
Reaction time trials correct on left0.20.30.60.1-0.5-0.50.6-0.60.6-0.60.60.8-0.6-0.60.7-0.50.50.5
Reaction time trials on left0.30.40.70.2-0.6-0.60.7-0.70.7-0.70.70.8-0.7-0.70.8-0.60.50.6
Reaction time mean0.30.41.81.3-0.10.1-0.70.7-0.70.7-0.6-0.60.60.6-0.40.4-0.4-0.5
Reaction time mean AUC0.30.32.21.5-0.2-0.0-0.60.6-0.60.6-0.5-0.50.50.5-0.30.3-0.3-0.4
Median of all reaction times0.20.33.21.8-0.5-0.3-0.40.4-0.40.4-0.4-0.20.30.3-0.10.1-0.1-0.2
Reaction time omissions0.50.61.21.1-1.0-0.90.7-0.50.7-0.70.70.8-0.7-0.71.0-0.70.60.7
Reaction time false alarm rate0.20.33.11.8-0.6-0.50.00.20.1-0.10.0-0.10.00.0-0.10.10.1-0.0
Reaction time premature initiation rate1.62.23.0-1.71.71.7-1.51.5-1.51.5-1.5-1.51.51.5-1.21.3-1.3-1.3
Reaction time premature initiations0.40.61.7-1.31.00.9-0.70.8-0.70.7-0.7-0.70.80.8-0.50.6-0.6-0.6
Std. dev. reaction times1.21.62.60.01.01.1-1.51.6-1.51.5-1.4-1.41.41.4-1.11.1-1.2-1.2
Reaction time trials completed0.30.40.70.2-0.6-0.60.7-0.70.7-0.70.70.8-0.7-0.70.8-0.60.50.6
Reaction time trials AUC0.10.20.40.1-0.4-0.40.5-0.50.5-0.50.50.6-0.5-0.50.6-0.40.30.4
Run reversals in cocaine runway, females0.30.20.5-0.60.60.6-0.50.5-0.50.5-0.5-0.30.30.3-0.30.7-0.6-0.3
Run reversals in cocaine runway, males0.10.10.50.7-0.4-0.40.3-0.30.2-0.20.2-0.10.10.10.1-0.30.30.1
Latency to leave start box in cocaine runway0.10.11.01.0-0.6-0.4-0.0-0.00.0-0.00.0-0.00.00.00.5-0.10.10.0
Latency to leave start box in cocaine runway, F0.30.30.60.80.10.2-0.60.6-0.60.6-0.6-0.60.60.6-0.30.7-0.6-0.5
Latency to leave start box in cocaine runway, M0.80.81.40.9-1.0-1.00.8-0.80.9-0.90.90.9-0.7-0.71.2-0.90.90.7
Std. dev. time between licks in bursts3.54.24.7-1.32.02.1-2.22.1-2.12.1-2.1-2.12.12.1-2.12.0-2.0-2.0
Total sessions with >9 infusions0.50.63.9-2.00.30.20.3-0.20.3-0.30.30.8-0.7-0.71.0-0.60.60.6
Short access day 1 total inactive lever presses0.40.40.60.70.30.4-0.70.6-0.70.7-0.7-0.70.80.8-0.70.5-0.5-0.6
Short access day 10 total inactive lever presses0.20.31.61.2-0.7-0.70.4-0.50.4-0.40.40.3-0.3-0.30.2-0.20.30.3
Short access day 1 total infusions0.80.92.8-1.71.21.2-1.01.1-1.01.0-1.0-0.50.70.7-0.30.6-0.6-0.7
Short access day 10 total infusions0.50.62.0-1.41.01.0-0.80.8-0.80.8-0.8-0.30.20.2-0.20.6-0.6-0.7
Short access total infusions0.40.42.1-1.51.00.9-0.60.8-0.60.6-0.6-0.20.30.3-0.10.3-0.4-0.4
Short access day 1 locomotion0.90.91.6-0.6-0.5-0.60.8-0.90.8-0.80.81.3-1.1-1.11.2-1.31.11.1
Short access day 10 total locomotion0.30.30.40.1-0.6-0.60.7-0.60.7-0.70.70.6-0.6-0.60.7-0.40.60.4
Short access total locomotion0.20.20.5-0.0-0.4-0.40.3-0.40.3-0.30.40.6-0.6-0.60.7-0.50.50.4
One hour access (0.3 mA shock)0.10.20.8-0.90.1-0.00.2-0.20.2-0.20.20.4-0.3-0.30.6-0.50.40.4
Compulsive drug intake0.50.50.90.9-0.9-0.90.7-0.90.7-0.70.70.4-0.1-0.10.5-0.80.70.7
One hour access (shock baseline)0.30.31.5-1.20.80.8-0.50.7-0.50.5-0.5-0.20.10.1-0.20.3-0.3-0.3
Social response proportion0.10.10.60.8-0.3-0.30.5-0.30.5-0.50.5-0.20.20.2-0.30.1-0.1-0.0
Social responses0.30.40.70.50.30.4-0.50.6-0.50.5-0.5-0.60.80.8-0.80.8-0.8-0.7
Social time1.11.53.11.7-1.5-1.41.0-1.01.1-1.11.11.3-1.2-1.21.2-1.11.01.1
Soleus weight0.30.81.10.50.50.6-0.80.9-0.90.9-0.9-1.11.01.0-1.01.0-1.0-1.0
Bone: stiffness2.74.35.40.31.51.7-2.22.3-2.12.1-2.1-2.32.32.3-2.32.2-2.2-2.2
Tibialis anterior weight0.20.81.0-0.50.90.9-1.00.9-1.01.0-1.0-1.00.90.9-0.90.9-0.9-0.9
Time to tail flick, vehicle, before self-admin0.00.00.2-0.40.30.3-0.00.20.0-0.00.00.2-0.3-0.30.1-0.1-0.00.2
Time to tail flick, vehicle, after self-admin0.50.62.4-1.61.01.0-0.80.7-0.80.8-0.8-0.30.20.2-0.40.5-0.6-0.6
Time to tail flick, test, before self-admin2.02.02.6-1.51.61.5-1.31.3-1.31.3-1.3-1.41.41.4-1.61.4-1.4-1.4
Time to tail flick, test, after self-admin5.05.27.0-1.52.32.3-2.12.1-2.12.1-2.1-2.62.62.6-2.52.4-2.3-2.3
Delta time to tail flick, vehicle, before/after SA0.00.00.4-0.60.20.1-0.1-0.0-0.20.2-0.20.1-0.0-0.00.00.1-0.0-0.1
Delta time to tail flick, test, before/after SA0.10.00.20.5-0.3-0.20.2-0.20.2-0.20.2-0.10.10.10.1-0.10.20.1
Tibia length0.30.81.7-1.31.11.0-0.80.8-0.80.8-0.8-0.80.80.8-0.80.7-0.7-0.8
Ambulatory time before self-admin1.01.01.41.1-1.1-1.10.8-0.90.8-0.80.81.1-0.9-0.91.0-1.21.21.1
Ambulatory time after self-admin0.20.20.5-0.70.0-0.10.1-0.10.1-0.10.10.4-0.5-0.50.6-0.60.70.5
Bone: tissue strength3.63.53.90.7-1.7-1.82.0-1.92.0-2.02.01.9-1.9-1.92.0-1.91.91.9
Total heroin consumption0.10.10.8-0.90.10.00.2-0.30.2-0.20.20.5-0.5-0.50.4-0.20.10.1
Bone: trabecular number1.11.72.31.3-1.5-1.51.3-1.21.3-1.31.31.2-1.2-1.21.3-1.31.31.3
Bone: trabecular spacing0.50.70.9-0.6-0.4-0.50.9-1.00.9-0.90.90.9-0.9-0.90.9-0.80.80.8
Bone: trabecular thickness2.32.73.3-0.11.31.4-1.81.8-1.81.8-1.8-1.81.81.8-1.71.7-1.7-1.7
Bone: trabecular tissue density3.85.46.60.71.61.8-2.42.5-2.42.4-2.4-2.52.52.5-2.42.6-2.6-2.6
Water consumed over 24 hours0.20.30.91.0-0.7-0.60.5-0.50.5-0.50.50.4-0.4-0.40.4-0.30.30.3
Number of responses in last shaping day1.01.01.9-0.20.91.0-1.21.4-1.21.2-1.2-0.91.11.1-0.70.8-1.0-0.9