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Intermittent access terminal intake (last 3 days)

Intermittent access terminal intake (last 3 days)

Tags: Behavior · Intermittent access · Cocaine

Project: p50_paul_meyer_2020

1 loci · 1 genes with independent associations · 1 total associated genes

Significant Loci

#	Chr	Start pos	End pos	# assoc genes	# joint models	Best TWAS P	Best GWAS P	Cond GWAS P	Joint genes
1	3	89760933	91151703	1	1	2.47e-07	1.66e-03	5.37e-06	Cd59

Pleiotropic Associations

Trait	Chi2 ratio	# genes+	# genes++	% genes++	Corr	Corr P	Genes
BMI with tail	1.8	1	0	0	0	1e+00	Cd59
BMI without tail	2.14	1	0	0	0	1e+00	Cd59
Heart weight	2.71	1	0	0	0	1e+00	Cd59
Extensor digitorum longus weight	1	1	0	0	0	1e+00	Cd59
Soleus weight	4.92	1	0	0	0	1e+00	Cd59
Tibialis anterior weight	1.19	1	0	0	0	1e+00	Cd59
Number of licking bursts	3.61	1	0	0	0	1e+00	Cd59
Delay discounting water rate 18 sec	4.52	1	0	0	0	1e+00	Cd59
Delay discounting water rate 6 sec	3.69	1	0	0	0	1e+00	Cd59
Light reinforcement 2	3.09	1	0	0	0	1e+00	Cd59
Median of all reaction times	3.65	1	0	0	0	1e+00	Cd59
Reaction time omissions	7.75	1	0	0	0	1e+00	Cd59
Social response proportion	21.58	1	0	0	0	1e+00	Cd59
Social time	3.38	1	0	0	0	1e+00	Cd59
Conditioned reinforcement - actives	7.89	1	0	0	0	1e+00	Cd59
Intermitt. access day 1 inactive lever presses	33.4	1	1	100	0	1e+00	Cd59
Intermitt. access escalation Index	13.13	1	0	0	0	1e+00	Cd59
Intermittent access day 15 total infusions	9.06	1	0	0	0	1e+00	Cd59
Intermittent access total infusions	12	1	0	0	0	1e+00	Cd59
Intermittent access day 15 total locomotion	5.86	1	0	0	0	1e+00	Cd59
Lifetime Intake	10.97	1	0	0	0	1e+00	Cd59
Progressive ratio test 1 active lever presses	4.89	1	0	0	0	1e+00	Cd59
Progressive ratio test 1 breakpoint	7.2	1	0	0	0	1e+00	Cd59
Progressive ratio test 2 active lever presses	7.16	1	0	0	0	1e+00	Cd59
Progressive ratio test 2 breakpoint	8.98	1	0	0	0	1e+00	Cd59
Short access day 10 total inactive lever presses	6.43	1	0	0	0	1e+00	Cd59
Short access day 1 total infusions	11.82	1	0	0	0	1e+00	Cd59
Short access day 10 total infusions	5.48	1	0	0	0	1e+00	Cd59
Short access total infusions	9.54	1	0	0	0	1e+00	Cd59
Short access day 1 locomotion	32.91	1	1	100	0	1e+00	Cd59
Short access total locomotion	12.88	1	0	0	0	1e+00	Cd59
Compulsive drug intake	4.08	1	0	0	0	1e+00	Cd59
One hour access (shock baseline)	20.37	1	0	0	0	1e+00	Cd59
Locomotion velocity, session 7	3.89	1	0	0	0	1e+00	Cd59
Degree of sensitization distance	4.08	1	0	0	0	1e+00	Cd59
Pavlov. Cond. intertrial magazine entries	4.9	1	0	0	0	1e+00	Cd59
Bone: cortical apparent density	4	1	0	0	0	1e+00	Cd59
Bone: cortical tissue density	3.66	1	0	0	0	1e+00	Cd59
Bone: trabecular tissue density	4.03	1	0	0	0	1e+00	Cd59
Breakpoint value in progressive ratio session	3.63	1	0	0	0	1e+00	Cd59
Distance traveled before self-admin	5.94	1	0	0	0	1e+00	Cd59
Distance traveled after self-admin	6.21	1	0	0	0	1e+00	Cd59
Delta time in open arm before/after self-admin	7.85	1	0	0	0	1e+00	Cd59
Active lever presses in extinction session 6	6.92	1	0	0	0	1e+00	Cd59
Time in closed arm before self-admin	3.42	1	0	0	0	1e+00	Cd59
Time to tail flick, vehicle, before self-admin	5.09	1	0	0	0	1e+00	Cd59
Time to tail flick, vehicle, after self-admin	12.11	1	0	0	0	1e+00	Cd59
Time to tail flick, test, before self-admin	7.41	1	0	0	0	1e+00	Cd59
Ambulatory time before self-admin	5.17	1	0	0	0	1e+00	Cd59
Ambulatory time after self-admin	9.11	1	0	0	0	1e+00	Cd59
Total heroin consumption	5.03	1	0	0	0	1e+00	Cd59
Area under the delay curve	3.93	1	0	0	0	1e+00	Cd59
Delay discount exponential model param	5.13	1	0	0	0	1e+00	Cd59
Delay discount hyperbolic model param	5.01	1	0	0	0	1e+00	Cd59
Fecal boli incidents, locomotor time 1	8.31	1	0	0	0	1e+00	Cd59
Change in fecal boli incidents, locomotor task	17.13	1	0	0	0	1e+00	Cd59
Bouts of movement, locomotor time 1	7.3	1	0	0	0	1e+00	Cd59
Total resting periods, locomotor time 1	3.75	1	0	0	0	1e+00	Cd59
Rest time, locomotor task time 1	5.98	1	0	0	0	1e+00	Cd59
Vertical activity count, locomotor time 1	6.55	1	0	0	0	1e+00	Cd59
Bouts of movement, locomotor time 2	17.43	1	0	0	0	1e+00	Cd59
Total resting periods, locomotor time 2	15.7	1	0	0	0	1e+00	Cd59
Run reversals in cocaine runway, females	15.16	1	0	0	0	1e+00	Cd59
Run reversals in cocaine runway, males	8.61	1	0	0	0	1e+00	Cd59
K content in liver	7.24	1	0	0	0	1e+00	Cd59
Mg content in liver	5.59	1	0	0	0	1e+00	Cd59

Associations by panel

Tissue	RNA modality	# hits	% hits/tests	Avg chisq
Adipose	alternative polyA	0	0	1.07
Adipose	alternative TSS	0	0	1.15
Adipose	gene expression	0	0	1.1
Adipose	isoform ratio	1	0	1.12
Adipose	intron excision ratio	0	0	1.04
Adipose	mRNA stability	0	0	1.11
BLA	alternative polyA	0	0	1.11
BLA	alternative TSS	0	0	1.02
BLA	gene expression	0	0	1.11
BLA	isoform ratio	0	0	1.08
BLA	intron excision ratio	0	0	1.05
BLA	mRNA stability	0	0	1.09
Brain	alternative polyA	0	0	1.09
Brain	alternative TSS	0	0	1.04
Brain	gene expression	0	0	1.1
Brain	isoform ratio	0	0	1.12
Brain	intron excision ratio	0	0	1.06
Brain	mRNA stability	0	0	1.09
Eye	alternative polyA	0	0	1.1
Eye	alternative TSS	0	0	1.1
Eye	gene expression	0	0	1.12
Eye	isoform ratio	0	0	1.09
Eye	intron excision ratio	0	0	1.04
Eye	mRNA stability	0	0	1.23
IL	alternative polyA	0	0	1.06
IL	alternative TSS	0	0	1.17
IL	gene expression	0	0	1.12
IL	isoform ratio	0	0	1.1
IL	intron excision ratio	0	0	1.14
IL	mRNA stability	0	0	1.15
LHb	alternative polyA	0	0	1.11
LHb	alternative TSS	0	0	1.16
LHb	gene expression	0	0	1.11
LHb	isoform ratio	0	0	1.07
LHb	intron excision ratio	0	0	1.02
LHb	mRNA stability	0	0	1.12
Liver	alternative polyA	0	0	0.95
Liver	alternative TSS	0	0	1.16
Liver	gene expression	0	0	1.1
Liver	isoform ratio	0	0	1.12
Liver	intron excision ratio	0	0	1.13
Liver	mRNA stability	0	0	1.11
NAcc	alternative polyA	0	0	1.06
NAcc	alternative TSS	0	0	1.13
NAcc	gene expression	0	0	1.1
NAcc	isoform ratio	0	0	1.09
NAcc	intron excision ratio	0	0	1.04
NAcc	mRNA stability	0	0	1.11
OFC	alternative polyA	0	0	1.06
OFC	alternative TSS	0	0	1.08
OFC	gene expression	0	0	1.14
OFC	isoform ratio	0	0	1.11
OFC	intron excision ratio	0	0	1.01
OFC	mRNA stability	0	0	1.13
PL	alternative polyA	0	0	1.11
PL	alternative TSS	0	0	1.06
PL	gene expression	0	0	1.11
PL	isoform ratio	0	0	1.12
PL	intron excision ratio	0	0	1.04
PL	mRNA stability	0	0	1.12