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Intermittent access terminal intake (last 3 days)

Intermittent access terminal intake (last 3 days)

Tags: Behavior · Intermittent access · Cocaine

Project: p50_paul_meyer_2020

5 loci · 5 genes with independent associations · 5 total associated genes

Significant Loci

#	Chr	Start pos	End pos	# assoc genes	# joint models	Best TWAS P	Best GWAS P	Cond GWAS P	Joint genes
1	chr4	97220462	98544003	1	1	1.33e-07	9.67e-02	1.00e+00	Il12rb2
2	chr7	92127461	93523291	1	1	8.54e-10	3.95e-02	9.45e-02	Nsmce2
3	chr8	41432021	42517271	1	1	4.80e-15	5.58e-02	2.38e-04	Foxred1
4	chr9	83390749	84777604	1	1	0.00e+00	7.98e-02	1.00e+00	Retreg2
5	chr13	84702566	86100919	1	1	1.87e-08	1.79e-01	1.28e-08	Olfml2b

Pleiotropic Associations

Trait	Chi2 ratio	# genes+	# genes++	% genes++	Corr	Corr P	Genes
BMI with tail	772.14	5	2	40	-1	1.82e-04	Foxred1 Il12rb2 Nsmce2 Olfml2b Retreg2
BMI without tail	48004.83	3	1	20	0	1.00e+00	Il12rb2 Olfml2b Retreg2
Body weight	3.21	3	0	0	0	1.00e+00	Nsmce2 Olfml2b Retreg2
Epididymis fat weight	108443.4	1	1	20	0	1.00e+00	Retreg2
Glucose	1185.47	2	1	20	0	1.00e+00	Nsmce2 Retreg2
Heart weight	6756.81	2	1	20	0	1.00e+00	Il12rb2 Retreg2
Left kidney weight	35316.23	4	1	20	-1	4.82e-05	Foxred1 Il12rb2 Olfml2b Retreg2
Right kidney weight	58424.37	2	1	20	0	1.00e+00	Foxred1 Retreg2
Tail length	92117.69	1	1	20	0	1.00e+00	Retreg2
Length with tail	2047.74	3	1	20	0	1.00e+00	Foxred1 Il12rb2 Retreg2
Length without tail	129313.22	1	1	20	0	1.00e+00	Retreg2
Liver weight, left	14514.29	1	1	20	0	1.00e+00	Retreg2
Liver weight, right	252.56	1	1	20	0	1.00e+00	Retreg2
Parametrial fat weight	207.79	3	1	20	0	1.00e+00	Foxred1 Nsmce2 Retreg2
Retroperitoneal fat weight	5353.46	3	1	20	0	1.00e+00	Il12rb2 Nsmce2 Retreg2
Intraocular pressure	40071.91	1	1	20	0	1.00e+00	Retreg2
Extensor digitorum longus weight	2342.22	2	1	20	0	1.00e+00	Nsmce2 Retreg2
Soleus weight	60.83	2	1	20	0	1.00e+00	Olfml2b Retreg2
Tibialis anterior weight	2442.27	2	1	20	0	1.00e+00	Olfml2b Retreg2
Tibia length	3259.43	1	1	20	0	1.00e+00	Retreg2
Number of licking bursts	157119.65	1	1	20	0	1.00e+00	Retreg2
Food consumed during 24 hour testing period	106196.53	1	1	20	0	1.00e+00	Retreg2
Times rat made contact with spout	305.36	1	1	20	0	1.00e+00	Retreg2
Mean time between licks in bursts	199507.71	1	1	20	0	1.00e+00	Retreg2
Mean num. licks in bursts	142600.29	1	1	20	0	1.00e+00	Retreg2
Std. dev. time between licks in bursts	94042.02	1	1	20	0	1.00e+00	Retreg2
Water consumed over 24 hours	103408.69	1	1	20	0	1.00e+00	Retreg2
Patch foraging indifference point 0 sec	57516.69	2	2	40	0	1.00e+00	Il12rb2 Retreg2
Patch foraging indifference point AUC	133114.6	1	1	20	0	1.00e+00	Retreg2
Indifference point function ln k	71005.61	2	1	20	0	1.00e+00	Olfml2b Retreg2
Indifference point function log k	71005.61	2	1	20	0	1.00e+00	Olfml2b Retreg2
Patch foraging total patch changes 0 sec	40098.47	3	2	40	0	1.00e+00	Foxred1 Il12rb2 Retreg2
Patch foraging total patch changes 12 sec	5427.22	2	1	20	0	1.00e+00	Foxred1 Retreg2
Patch foraging total patch changes 18 sec	117768.16	1	1	20	0	1.00e+00	Retreg2
Patch foraging total patch changes 24 sec	83546.94	2	1	20	0	1.00e+00	Il12rb2 Retreg2
Patch foraging total patch changes 6 sec	16328.79	2	2	40	0	1.00e+00	Il12rb2 Retreg2
Patch foraging time to switch 0 sec	78311.47	2	1	20	0	1.00e+00	Olfml2b Retreg2
Patch foraging water rate 0 sec	74405.18	2	1	20	0	1.00e+00	Olfml2b Retreg2
Patch foraging water rate 12 sec	161858.08	1	1	20	0	1.00e+00	Retreg2
Patch foraging water rate 18 sec	51642.01	2	1	20	0	1.00e+00	Il12rb2 Retreg2
Patch foraging water rate 24 sec	4691.77	1	1	20	0	1.00e+00	Retreg2
Patch foraging water rate 6 sec	3954.86	1	1	20	0	1.00e+00	Retreg2
Locomotor activity	9.97	3	0	0	0	1.00e+00	Foxred1 Il12rb2 Retreg2
Locomotor testing distance	29821.16	3	1	20	0	1.00e+00	Foxred1 Il12rb2 Retreg2
Locomotor testing rearing	50806.94	3	1	20	0	1.00e+00	Foxred1 Il12rb2 Retreg2
Light reinforcement 1	155242.72	1	1	20	0	1.00e+00	Retreg2
Light reinforcement 2	35969.93	3	1	20	0	1.00e+00	Il12rb2 Olfml2b Retreg2
Reaction time number correct	76735.13	2	1	20	0	1.00e+00	Olfml2b Retreg2
Reaction time mean minus median	102906.4	2	1	20	0	1.00e+00	Olfml2b Retreg2
Reaction time mean minus median AUC	104199.07	2	1	20	0	1.00e+00	Olfml2b Retreg2
Reaction time num false alarms	57075.22	1	1	20	0	1.00e+00	Retreg2
Reaction time num false alarms AUC	106496.51	1	1	20	0	1.00e+00	Retreg2
Reaction time trials correct on left	76735.13	2	1	20	0	1.00e+00	Olfml2b Retreg2
Reaction time trials on left	74998.43	2	1	20	0	1.00e+00	Olfml2b Retreg2
Reaction time mean	47193.18	2	1	20	0	1.00e+00	Il12rb2 Retreg2
Reaction time mean AUC	56673.35	2	1	20	0	1.00e+00	Il12rb2 Retreg2
Median of all reaction times	15711.8	2	1	20	0	1.00e+00	Il12rb2 Retreg2
Reaction time omissions	34267.91	1	1	20	0	1.00e+00	Retreg2
Reaction time false alarm rate	891.26	1	1	20	0	1.00e+00	Retreg2
Reaction time premature initiation rate	18447.27	2	2	40	0	1.00e+00	Nsmce2 Retreg2
Reaction time premature initiations	69362.11	2	1	20	0	1.00e+00	Nsmce2 Retreg2
Std. dev. reaction times	49831.67	3	1	20	0	1.00e+00	Il12rb2 Olfml2b Retreg2
Reaction time trials completed	74998.43	2	1	20	0	1.00e+00	Olfml2b Retreg2
Reaction time trials AUC	75850.7	2	1	20	0	1.00e+00	Olfml2b Retreg2
Social response proportion	17656.73	2	1	20	0	1.00e+00	Il12rb2 Retreg2
Social responses	1903.66	3	1	20	0	1.00e+00	Il12rb2 Nsmce2 Retreg2
Social time	44238.34	1	1	20	0	1.00e+00	Retreg2
Conditioned locomotion	6074.35	1	1	20	0	1.00e+00	Retreg2
Cocaine response after cond. corrected	65812.39	1	1	20	0	1.00e+00	Retreg2
Cocaine response after cond. not corrected	64247.35	1	1	20	0	1.00e+00	Retreg2
Cocaine response before conditioning	1404.42	2	1	20	0	1.00e+00	Il12rb2 Retreg2
Saline control response	12962.78	1	1	20	0	1.00e+00	Retreg2
Condit. Reinf. active minus inactive responses	53410.48	1	1	20	0	1.00e+00	Retreg2
Condit. Reinf. active-inactive response ratio	91582.24	1	1	20	0	1.00e+00	Retreg2
Condit. Reinf. active responses	9691.24	1	1	20	0	1.00e+00	Retreg2
Condit. Reinf. inactive responses	42106.18	1	1	20	0	1.00e+00	Retreg2
Condit. Reinf. lever presses	15873.43	1	1	20	0	1.00e+00	Retreg2
Condit. Reinf. lever reinforcers received	2000.77	1	1	20	0	1.00e+00	Retreg2
Pavlov. Cond. lever latency	10912.53	1	1	20	0	1.00e+00	Retreg2
Pavlov. Cond. magazine entry latency	49418.79	1	1	20	0	1.00e+00	Retreg2
Pavlov. Cond. change in total contacts	114781.94	1	1	20	0	1.00e+00	Retreg2
Pavlov. Cond. index score	47988.08	1	1	20	0	1.00e+00	Retreg2
Pavlov. Cond. latency score	58476.16	1	1	20	0	1.00e+00	Retreg2
Pavlov. Cond. lever contacts	22069.78	1	1	20	0	1.00e+00	Retreg2
Pavlov. Cond. magazine entry number	16773.11	1	1	20	0	1.00e+00	Retreg2
Pavlov. Cond. intertrial magazine entries	104933.78	1	1	20	0	1.00e+00	Retreg2
Pavlov. Cond. lever-magazine prob. diff.	44871.67	1	1	20	0	1.00e+00	Retreg2
Pavlov. Cond. response bias	5169.79	1	1	20	0	1.00e+00	Retreg2
Conditioned reinforcement - actives	95747.86	2	1	20	0	1.00e+00	Olfml2b Retreg2
Conditioned reinforcement - inactives	31011.03	5	1	20	1	5.63e-08	Foxred1 Il12rb2 Nsmce2 Olfml2b Retreg2
Conditioned locomotion	13788.41	3	1	20	0	1.00e+00	Foxred1 Olfml2b Retreg2
Intermittent access intake day 1-15 change	52655.75	4	2	40	1	4.62e-07	Foxred1 Il12rb2 Olfml2b Retreg2
Intermittent access intake escalation	69858.86	3	2	40	0	1.00e+00	Foxred1 Olfml2b Retreg2
Intermittent access intake escalation 2	27020.92	4	2	40	1	7.34e-05	Foxred1 Il12rb2 Olfml2b Retreg2
Intermitt. access day 1 inactive lever presses	118271.74	2	1	20	0	1.00e+00	Olfml2b Retreg2
Intermitt. access day 15 inactive lever presses	69420.71	3	3	60	0	1.00e+00	Foxred1 Olfml2b Retreg2
Intermitt. access escalation Index	46253.12	4	1	20	-1	1.46e-06	Il12rb2 Nsmce2 Olfml2b Retreg2
Intermittent access day 1 total infusions	38885.34	4	1	20	-1	1.54e-05	Foxred1 Nsmce2 Olfml2b Retreg2
Intermittent access day 15 total infusions	26309.24	5	3	60	1	1.67e-08	Foxred1 Il12rb2 Nsmce2 Olfml2b Retreg2
Intermittent access total infusions	150.27	5	1	20	-1	3.90e-05	Foxred1 Il12rb2 Nsmce2 Olfml2b Retreg2
Intermittent access day 1 locomotion	26121.37	4	2	40	-1	6.61e-05	Foxred1 Nsmce2 Olfml2b Retreg2
Intermittent access day 15 total locomotion	59280.96	3	1	20	0	1.00e+00	Nsmce2 Olfml2b Retreg2
Intermittent access total locomotion	186.15	4	1	20	1	1.32e-04	Il12rb2 Nsmce2 Olfml2b Retreg2
Intermittent access standard deviation	50478.84	4	1	20	1	1.44e-05	Foxred1 Nsmce2 Olfml2b Retreg2
Cocaine induced anxiety	53430.15	3	1	20	0	1.00e+00	Foxred1 Il12rb2 Retreg2
Post-drug Anxiety	10237.65	2	1	20	0	1.00e+00	Il12rb2 Retreg2
Baseline Anxiety	51738.82	2	1	20	0	1.00e+00	Foxred1 Retreg2
Lifetime Intake	1378.9	5	1	20	-1	2.63e-06	Foxred1 Il12rb2 Nsmce2 Olfml2b Retreg2
Incentive Sensitization - Responses	81791.87	2	1	20	0	1.00e+00	Olfml2b Retreg2
Incentive Sensitization - Breakpoint	47600.24	3	1	20	0	1.00e+00	Foxred1 Olfml2b Retreg2
Progressive ratio test 1 active lever presses	33294.49	3	1	20	0	1.00e+00	Nsmce2 Olfml2b Retreg2
Progressive ratio test 1 breakpoint	32086.02	3	1	20	0	1.00e+00	Nsmce2 Olfml2b Retreg2
Progressive ratio test 1 inactive lever presses	50370.08	3	1	20	0	1.00e+00	Foxred1 Il12rb2 Retreg2
Progressive ratio test 2 active lever presses	19079.23	3	1	20	0	1.00e+00	Nsmce2 Olfml2b Retreg2
Progressive ratio test 2 breakpoint	11664.19	3	1	20	0	1.00e+00	Nsmce2 Olfml2b Retreg2
Progressive ratio test 2 inactive lever presses	54705.7	3	1	20	0	1.00e+00	Foxred1 Nsmce2 Retreg2
Total sessions with >9 infusions	1995.61	4	1	20	-1	5.28e-05	Il12rb2 Nsmce2 Olfml2b Retreg2
Short access day 1 total inactive lever presses	38140.84	3	2	40	0	1.00e+00	Foxred1 Il12rb2 Retreg2
Short access day 10 total inactive lever presses	72382.38	3	1	20	0	1.00e+00	Il12rb2 Olfml2b Retreg2
Short access day 1 total infusions	27877.47	4	2	40	-1	5.85e-06	Foxred1 Il12rb2 Nsmce2 Retreg2
Short access day 10 total infusions	25436.89	3	1	20	0	1.00e+00	Nsmce2 Olfml2b Retreg2
Short access total infusions	11322.83	3	1	20	0	1.00e+00	Il12rb2 Nsmce2 Retreg2
Short access day 1 locomotion	42034.69	2	1	20	0	1.00e+00	Foxred1 Retreg2
Short access day 10 total locomotion	60541.04	3	3	60	0	1.00e+00	Foxred1 Olfml2b Retreg2
Short access total locomotion	22766.91	3	2	40	0	1.00e+00	Foxred1 Olfml2b Retreg2
Compulsive drug intake	16369.91	4	2	40	-1	4.46e-04	Foxred1 Il12rb2 Nsmce2 Retreg2
One hour access (0.3 mA shock)	3248.82	3	2	40	0	1.00e+00	Foxred1 Il12rb2 Retreg2
One hour access (shock baseline)	46758.51	3	1	20	0	1.00e+00	Foxred1 Nsmce2 Retreg2
Number of responses in last shaping day	17105.41	3	1	20	0	1.00e+00	Foxred1 Il12rb2 Retreg2
Context. condit. distance diff. score	970.59	1	1	20	0	1.00e+00	Retreg2
Locomotion velocity, session 1	7312.87	2	1	20	0	1.00e+00	Il12rb2 Retreg2
Locomotion distance, session 1	2213.9	2	1	20	0	1.00e+00	Il12rb2 Retreg2
Locomotion velocity, session 2	9358	1	1	20	0	1.00e+00	Retreg2
Locomotion distance, session 2	1205.23	2	1	20	0	1.00e+00	Il12rb2 Retreg2
Locomotion velocity, session 3	2332.53	1	1	20	0	1.00e+00	Retreg2
Locomotion distance, session 3	16615.78	1	1	20	0	1.00e+00	Retreg2
Stereotopy head waving bouts, day 3	5866.4	1	1	20	0	1.00e+00	Retreg2
Stereotopy head waving duration, day 3	12131.92	1	1	20	0	1.00e+00	Retreg2
Locomotion velocity, session 7	1310.17	1	1	20	0	1.00e+00	Retreg2
Locomotion distance, session 7	3744.54	1	1	20	0	1.00e+00	Retreg2
Stereotopy head waving bouts, day 7	10466.92	1	1	20	0	1.00e+00	Retreg2
Stereotopy head waving duration, day 7	8847.36	1	1	20	0	1.00e+00	Retreg2
Locomotion velocity, session 8	1892.98	1	1	20	0	1.00e+00	Retreg2
Locomotion distance, session 8	673.32	1	1	20	0	1.00e+00	Retreg2
Degree of sensitization distance	15309.16	1	1	20	0	1.00e+00	Retreg2
Degree of sensitization stereotypy	8496.38	1	1	20	0	1.00e+00	Retreg2
Condit. Reinf. active minus inactive responses	4120.78	1	1	20	0	1.00e+00	Retreg2
Condit. Reinf. active-inactive response ratio	1097.66	1	1	20	0	1.00e+00	Retreg2
Condit. Reinf. active responses	11664.93	1	1	20	0	1.00e+00	Retreg2
Condit. Reinf. inactive responses	19375.3	1	1	20	0	1.00e+00	Retreg2
Incentive salience index mean	14781.83	1	1	20	0	1.00e+00	Retreg2
Condit. Reinf. lever presses	21433.81	1	1	20	0	1.00e+00	Retreg2
Time in familiar zone, hab. session 1	41873.03	1	1	20	0	1.00e+00	Retreg2
Time in novel zone, hab. session 1	35522.88	1	1	20	0	1.00e+00	Retreg2
Total zone transitions, hab. session 1	1818.53	1	1	20	0	1.00e+00	Retreg2
Total locomotion distance, hab. session 1	846.08	2	1	20	0	1.00e+00	Il12rb2 Retreg2
Locomotion velocity, hab. session 1	568.78	2	1	20	0	1.00e+00	Il12rb2 Retreg2
Time in familiar zone, hab. session 2	23379.25	1	1	20	0	1.00e+00	Retreg2
Time in novel zone, hab. session 2	24924.95	1	1	20	0	1.00e+00	Retreg2
Total zone transitions, hab. session 2	143.63	2	1	20	0	1.00e+00	Il12rb2 Retreg2
Total locomotion distance, hab. session 2	96.8	1	1	20	0	1.00e+00	Retreg2
Locomotion velocity, hab. session 2	75.48	2	1	20	0	1.00e+00	Il12rb2 Retreg2
Novel to familiar place preference ratio	55508.81	1	1	20	0	1.00e+00	Retreg2
Novelty place preference	54383.96	1	1	20	0	1.00e+00	Retreg2
Time in novel zone, NPP test	40844.77	1	1	20	0	1.00e+00	Retreg2
Total zone transitions, NPP test	4119.07	2	1	20	0	1.00e+00	Il12rb2 Retreg2
Total locomotion distance, NPP test	3561.28	2	1	20	0	1.00e+00	Il12rb2 Retreg2
Locomotion velocity, NPP test	2025.73	2	1	20	0	1.00e+00	Il12rb2 Retreg2
Pavlov. Cond. lever latency	1100.75	2	1	20	0	1.00e+00	Il12rb2 Retreg2
Pavlov. Cond. change in total contacts	4539.35	1	1	20	0	1.00e+00	Retreg2
Pavlov. Cond. index score	1769.33	1	1	20	0	1.00e+00	Retreg2
Pavlov. Cond. latency score	1841.19	1	1	20	0	1.00e+00	Retreg2
Pavlov. Cond. lever contacts	1517.91	2	1	20	0	1.00e+00	Il12rb2 Retreg2
Pavlov. Cond. magazine entry number	2162.19	1	1	20	0	1.00e+00	Retreg2
Pavlov. Cond. intertrial magazine entries	266.85	2	1	20	0	1.00e+00	Olfml2b Retreg2
Pavlov. Cond. lever-magazine prob. diff.	1940.27	1	1	20	0	1.00e+00	Retreg2
Pavlov. Cond. response bias	2606.99	1	1	20	0	1.00e+00	Retreg2
Bone: apparent density	22268.03	1	1	20	0	1.00e+00	Retreg2
Bone surface	25125.6	1	1	20	0	1.00e+00	Retreg2
Bone volume	33831.7	1	1	20	0	1.00e+00	Retreg2
Bone: connectivity density	7098.55	1	1	20	0	1.00e+00	Retreg2
Bone: cortical apparent density	45266.32	1	1	20	0	1.00e+00	Retreg2
Bone: cortical area	18930.98	1	1	20	0	1.00e+00	Retreg2
Bone: cortical porosity	1837.29	1	1	20	0	1.00e+00	Retreg2
Bone: cortical porosity	4807.78	1	1	20	0	1.00e+00	Retreg2
Bone: cortical thickness	1627.26	1	1	20	0	1.00e+00	Retreg2
Bone: cortical thickness	6098.18	2	1	20	0	1.00e+00	Olfml2b Retreg2
Bone: cortical tissue density	48453.42	1	1	20	0	1.00e+00	Retreg2
Bone: elastic displacement	29626.25	1	1	20	0	1.00e+00	Retreg2
Bone: elastic work	1494.59	1	1	20	0	1.00e+00	Retreg2
Bone: endosteal estimation	35257.61	1	1	20	0	1.00e+00	Retreg2
Bone: endosteal perimeter	44697.39	1	1	20	0	1.00e+00	Retreg2
Bone: final force	7031.22	1	1	20	0	1.00e+00	Retreg2
Bone: final moment	1042.62	1	1	20	0	1.00e+00	Retreg2
Bone: marrow area	37067.95	1	1	20	0	1.00e+00	Retreg2
Bone: maximum diameter	24401.62	1	1	20	0	1.00e+00	Retreg2
Bone: maximum force	34553.99	1	1	20	0	1.00e+00	Retreg2
Bone: maximum moment	24715.64	1	1	20	0	1.00e+00	Retreg2
Bone: minimum diameter	17196.64	1	1	20	0	1.00e+00	Retreg2
Bone: periosteal estimation	38190.5	1	1	20	0	1.00e+00	Retreg2
Bone: periosteal perimeter	43183.28	1	1	20	0	1.00e+00	Retreg2
Bone: post-yield work	50847.58	1	1	20	0	1.00e+00	Retreg2
Bone: stiffness	17784.33	2	1	20	0	1.00e+00	Il12rb2 Retreg2
Bone: tissue strength	12264.67	1	1	20	0	1.00e+00	Retreg2
Bone: trabecular number	20571.19	2	1	20	0	1.00e+00	Nsmce2 Retreg2
Bone: trabecular spacing	31287.85	1	1	20	0	1.00e+00	Retreg2
Bone: trabecular thickness	33264.33	1	1	20	0	1.00e+00	Retreg2
Bone: trabecular tissue density	53620.06	1	1	20	0	1.00e+00	Retreg2
Breakpoint value in progressive ratio session	56215.92	2	1	20	0	1.00e+00	Nsmce2 Retreg2
Distance traveled before self-admin	44676.23	3	1	20	0	1.00e+00	Foxred1 Il12rb2 Retreg2
Distance traveled after self-admin	50416.54	2	1	20	0	1.00e+00	Foxred1 Retreg2
Delta time in closed arm before/after self-admin	330.76	4	1	20	0.98	2.07e-02	Foxred1 Il12rb2 Nsmce2 Retreg2
Delta time in open arm before/after self-admin	18275.37	3	1	20	0	1.00e+00	Nsmce2 Olfml2b Retreg2
Diff in mean of infusions in LGA sessions	54250.74	2	1	20	0	1.00e+00	Olfml2b Retreg2
Extinction: sum of active levers before priming	22903.88	4	2	40	1	2.57e-06	Foxred1 Il12rb2 Nsmce2 Retreg2
Active lever presses in extinction session 6	790.78	4	1	20	-0.99	8.40e-03	Foxred1 Il12rb2 Nsmce2 Retreg2
Delta distance traveled before/after self-admin	4150.77	3	1	20	0	1.00e+00	Foxred1 Il12rb2 Retreg2
Delta ambulatory time before/after self-admin	32020.98	3	2	40	0	1.00e+00	Foxred1 Il12rb2 Retreg2
Time in closed arm before self-admin	29419.92	3	2	40	0	1.00e+00	Foxred1 Il12rb2 Retreg2
Time in closed arm after self-admin	19471.75	1	1	20	0	1.00e+00	Retreg2
Time in open arm before self-admin	17297.9	2	1	20	0	1.00e+00	Il12rb2 Retreg2
Time in open arm after self-admin	638.06	3	1	20	0	1.00e+00	Foxred1 Il12rb2 Retreg2
Sum of active levers in priming session hrs 5-6	1319.89	3	2	40	0	1.00e+00	Il12rb2 Olfml2b Retreg2
Time to tail flick, vehicle, before self-admin	17122.52	3	2	40	0	1.00e+00	Foxred1 Il12rb2 Retreg2
Time to tail flick, vehicle, after self-admin	59145.9	2	1	20	0	1.00e+00	Foxred1 Retreg2
Time to tail flick, test, before self-admin	16406.33	2	1	20	0	1.00e+00	Foxred1 Retreg2
Time to tail flick, test, after self-admin	2918.79	2	1	20	0	1.00e+00	Foxred1 Retreg2
Delta time to tail flick, vehicle, before/after SA	18277.27	2	1	20	0	1.00e+00	Il12rb2 Retreg2
Delta time to tail flick, test, before/after SA	56832.34	1	1	20	0	1.00e+00	Retreg2
Ambulatory time before self-admin	57033.57	3	2	40	0	1.00e+00	Foxred1 Il12rb2 Retreg2
Ambulatory time after self-admin	88230.17	1	1	20	0	1.00e+00	Retreg2
Total heroin consumption	205.24	5	2	40	0.97	7.20e-03	Foxred1 Il12rb2 Nsmce2 Olfml2b Retreg2
Area under the delay curve	40808.45	2	1	20	0	1.00e+00	Olfml2b Retreg2
Delay disc. indifference point, 0s delay	4744.55	2	1	20	0	1.00e+00	Olfml2b Retreg2
Delay disc. indifference point, 16s delay	37404.98	2	1	20	0	1.00e+00	Olfml2b Retreg2
Delay disc. indifference point, 2s delay	416.05	2	1	20	0	1.00e+00	Olfml2b Retreg2
Delay disc. indifference point, 24s delay	49996.94	2	1	20	0	1.00e+00	Olfml2b Retreg2
Delay disc. indifference point, 4s delay	1271.69	2	1	20	0	1.00e+00	Olfml2b Retreg2
Delay disc. indifference point, 8s delay	101423.99	1	1	20	0	1.00e+00	Retreg2
Delay discount exponential model param	30113.85	2	1	20	0	1.00e+00	Olfml2b Retreg2
Delay discount hyperbolic model param	22865.52	2	1	20	0	1.00e+00	Olfml2b Retreg2
Fecal boli incidents, locomotor time 1	75084.33	2	1	20	0	1.00e+00	Olfml2b Retreg2
Change in fecal boli incidents, locomotor task	23481.3	1	1	20	0	1.00e+00	Retreg2
Time >=10cm from walls, locomotor time 1	16430.26	3	2	40	0	1.00e+00	Il12rb2 Olfml2b Retreg2
Bouts of movement, locomotor time 1	20804.38	2	1	20	0	1.00e+00	Il12rb2 Retreg2
Total resting periods, locomotor time 1	5910.71	2	1	20	0	1.00e+00	Il12rb2 Retreg2
Rest time, locomotor task time 1	37978.96	2	1	20	0	1.00e+00	Il12rb2 Retreg2
Distance moved, locomotor task time 1	79646.61	2	1	20	0	1.00e+00	Il12rb2 Retreg2
Vertical activity count, locomotor time 1	109531.89	2	1	20	0	1.00e+00	Il12rb2 Retreg2
Time >=10cm from walls, locomotor time 2	54000.76	3	2	40	0	1.00e+00	Il12rb2 Olfml2b Retreg2
Bouts of movement, locomotor time 2	43577.86	4	1	20	1	2.56e-05	Foxred1 Il12rb2 Olfml2b Retreg2
Total resting periods, locomotor time 2	47522.2	4	1	20	1	2.31e-05	Foxred1 Il12rb2 Olfml2b Retreg2
Rest time, locomotor task time 2	41891.72	2	1	20	0	1.00e+00	Olfml2b Retreg2
Distance moved, locomotor task time 2	34268.85	1	1	20	0	1.00e+00	Retreg2
Vertical activity count, locomotor time 2	138414.05	1	1	20	0	1.00e+00	Retreg2
Weight adjusted by age	161973.18	1	1	20	0	1.00e+00	Retreg2
Seeking ratio, delayed vs. immediate footshock	49395.56	1	1	20	0	1.00e+00	Retreg2
Locomotion in novel chamber	5441.69	3	1	20	0	1.00e+00	Il12rb2 Olfml2b Retreg2
Locomotion in novel chamber post-restriction	154642.04	1	1	20	0	1.00e+00	Retreg2
Progressive ratio	157894.89	1	1	20	0	1.00e+00	Retreg2
Food seeking constrained by brief footshock	3672.6	2	1	20	0	1.00e+00	Il12rb2 Retreg2
Seeking ratio, punishment vs. effort	59143.05	2	1	20	0	1.00e+00	Il12rb2 Retreg2
Run reversals in cocaine runway, females	12400.31	3	1	20	0	1.00e+00	Foxred1 Olfml2b Retreg2
Run reversals in cocaine runway, males	14937.45	2	1	20	0	1.00e+00	Foxred1 Retreg2
Latency to leave start box in cocaine runway	29292.5	2	1	20	0	1.00e+00	Olfml2b Retreg2
Latency to leave start box in cocaine runway, F	14193.29	2	1	20	0	1.00e+00	Olfml2b Retreg2
Latency to leave start box in cocaine runway, M	3574.92	2	1	20	0	1.00e+00	Foxred1 Retreg2
Co content in liver	4721.74	1	1	20	0	1.00e+00	Retreg2
Cu content in liver	162.43	1	1	20	0	1.00e+00	Retreg2
Fe content in liver	5656.2	1	1	20	0	1.00e+00	Retreg2
K content in liver	6593.53	1	1	20	0	1.00e+00	Retreg2
Mg content in liver	12254.82	2	1	20	0	1.00e+00	Olfml2b Retreg2
Mn content in liver	2193.4	2	1	20	0	1.00e+00	Olfml2b Retreg2
Na content in liver	8324.6	2	1	20	0	1.00e+00	Olfml2b Retreg2
Rb content in liver	217.33	2	1	20	0	1.00e+00	Olfml2b Retreg2
Se content in liver	7.21	1	0	0	0	1.00e+00	Olfml2b
Zn content in liver	15755.62	1	1	20	0	1.00e+00	Retreg2

Associations by panel

Tissue	RNA modality	# hits	% hits/tests	Avg chisq
Adipose	alternative polyA	0	0	1.14
Adipose	alternative TSS	0	0	1.18
Adipose	gene expression	0	0	1.19
Adipose	isoform ratio	0	0	1.13
Adipose	intron excision ratio	0	0	1.16
Adipose	mRNA stability	0	0	1.21
BLA	alternative polyA	0	0	1.11
BLA	alternative TSS	0	0	1.15
BLA	gene expression	0	0	1.22
BLA	isoform ratio	0	0	1.18
BLA	intron excision ratio	0	0	1.19
BLA	mRNA stability	0	0	1.18
Brain	alternative polyA	0	0	1.15
Brain	alternative TSS	0	0	1.17
Brain	gene expression	0	0	1.18
Brain	isoform ratio	0	0	1.22
Brain	intron excision ratio	0	0	1.22
Brain	mRNA stability	1	0	1.18
Eye	alternative polyA	0	0	0.92
Eye	alternative TSS	0	0	1.11
Eye	gene expression	0	0	1.2
Eye	isoform ratio	0	0	1.24
Eye	intron excision ratio	0	0	1.22
Eye	mRNA stability	0	0	1.2
IC	alternative polyA	0	0	1.13
IC	alternative TSS	0	0	1.19
IC	gene expression	0	0	1.23
IC	isoform ratio	0	0	1.19
IC	intron excision ratio	0	0	1.28
IC	mRNA stability	0	0	1.17
IL	alternative polyA	0	0	1.13
IL	alternative TSS	0	0	1.14
IL	gene expression	0	0	1.2
IL	isoform ratio	0	0	1.19
IL	intron excision ratio	0	0	1.21
IL	mRNA stability	0	0	1.19
LHb	alternative polyA	0	0	1.12
LHb	alternative TSS	0	0	1.33
LHb	gene expression	0	0	1.18
LHb	isoform ratio	0	0	1.26
LHb	intron excision ratio	0	0	1.13
LHb	mRNA stability	0	0	1.15
Liver	alternative polyA	0	0	1.23
Liver	alternative TSS	0	0	1.18
Liver	gene expression	0	0	1.19
Liver	isoform ratio	0	0	1.21
Liver	intron excision ratio	0	0	1.21
Liver	mRNA stability	0	0	1.19
NAcc	alternative polyA	2	0.1	41.96
NAcc	alternative TSS	0	0	1.18
NAcc	gene expression	0	0	1.19
NAcc	isoform ratio	0	0	1.17
NAcc	intron excision ratio	1	0	1.2
NAcc	mRNA stability	0	0	1.19
OFC	alternative polyA	0	0	1.15
OFC	alternative TSS	0	0	1.2
OFC	gene expression	0	0	1.19
OFC	isoform ratio	0	0	1.13
OFC	intron excision ratio	0	0	1.07
OFC	mRNA stability	0	0	1.19
PL	alternative polyA	0	0	1.18
PL	alternative TSS	0	0	1.2
PL	gene expression	1	0	1.18
PL	isoform ratio	0	0	1.2
PL	intron excision ratio	0	0	1.21
PL	mRNA stability	0	0	1.18
pVTA	alternative polyA	0	0	1.2
pVTA	alternative TSS	0	0	1.29
pVTA	gene expression	0	0	1.22
pVTA	isoform ratio	0	0	1.25
pVTA	intron excision ratio	0	0	1.22
pVTA	mRNA stability	0	0	1.18
RMTg	alternative polyA	0	0	1.11
RMTg	alternative TSS	0	0	1.21
RMTg	gene expression	0	0	1.27
RMTg	isoform ratio	0	0	1.22
RMTg	intron excision ratio	0	0	1.25
RMTg	mRNA stability	0	0	1.23