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Intermittent access terminal intake (last 3 days)

Intermittent access terminal intake (last 3 days)

Tags: Behavior · Intermittent access · Cocaine

Project: p50_paul_meyer_2020

1 significantly associated model · 1 unique gene

Significant Loci

# chr p0 p1 # assoc genes # joint models best TWAS P best SNP P cond SNP P % var exp joint genes
1 3 89760933 91151703 1 1 2.5e-07 0.0017 5.4e-06 -109 Cd59

p0: physical position of the start of the locus. p1: physical position of the end of the locus. # joint models: number of models selected by step-wise conditional analysis.

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
BMI with tail 1.8 1 0 0 0 1 Cd59
BMI without tail 2.1 1 0 0 0 1 Cd59
Heart weight 2.7 1 0 0 0 1 Cd59
Extensor digitorum longus weight 1.0 1 0 0 0 1 Cd59
Soleus weight 4.9 1 0 0 0 1 Cd59
Tibialis anterior weight 1.2 1 0 0 0 1 Cd59
Number of licking bursts 3.6 1 0 0 0 1 Cd59
Delay discounting water rate 18 sec 4.5 1 0 0 0 1 Cd59
Delay discounting water rate 6 sec 3.7 1 0 0 0 1 Cd59
Light reinforcement 2 3.1 1 0 0 0 1 Cd59
Median of all reaction times 3.6 1 0 0 0 1 Cd59
Reaction time omissions 7.8 1 0 0 0 1 Cd59
Social response proportion 21.6 1 0 0 0 1 Cd59
Social time 3.4 1 0 0 0 1 Cd59
Conditioned reinforcement - actives 7.9 1 0 0 0 1 Cd59
Intermitt. access day 1 inactive lever presses 33.4 1 1 100 0 1 Cd59
Intermitt. access escalation Index 13.1 1 0 0 0 1 Cd59
Intermittent access day 15 total infusions 9.1 1 0 0 0 1 Cd59
Intermittent access total infusions 12.0 1 0 0 0 1 Cd59
Intermittent access day 15 total locomotion 5.9 1 0 0 0 1 Cd59
Lifetime Intake 11.0 1 0 0 0 1 Cd59
Progressive ratio test 1 active lever presses 4.9 1 0 0 0 1 Cd59
Progressive ratio test 1 breakpoint 7.2 1 0 0 0 1 Cd59
Progressive ratio test 2 active lever presses 7.2 1 0 0 0 1 Cd59
Progressive ratio test 2 breakpoint 9.0 1 0 0 0 1 Cd59
Short access day 10 total inactive lever presses 6.4 1 0 0 0 1 Cd59
Short access day 1 total infusions 11.8 1 0 0 0 1 Cd59
Short access day 10 total infusions 5.5 1 0 0 0 1 Cd59
Short access total infusions 9.5 1 0 0 0 1 Cd59
Short access day 1 locomotion 32.9 1 1 100 0 1 Cd59
Short access total locomotion 12.9 1 0 0 0 1 Cd59
Compulsive drug intake 4.1 1 0 0 0 1 Cd59
One hour access (shock baseline) 20.4 1 0 0 0 1 Cd59
Locomotion velocity, session 7 3.9 1 0 0 0 1 Cd59
Degree of sensitization distance 4.1 1 0 0 0 1 Cd59
Pavlov. Cond. intertrial magazine entries 4.9 1 0 0 0 1 Cd59
Bone: cortical apparent density 4.0 1 0 0 0 1 Cd59
Bone: cortical tissue density 3.7 1 0 0 0 1 Cd59
Bone: trabecular tissue density 4.0 1 0 0 0 1 Cd59
Breakpoint value in progressive ratio session 3.6 1 0 0 0 1 Cd59
Distance traveled before self-admin 5.9 1 0 0 0 1 Cd59
Distance traveled after self-admin 6.2 1 0 0 0 1 Cd59
Delta time in open arm before/after self-admin 7.8 1 0 0 0 1 Cd59
Active lever presses in extinction session 6 6.9 1 0 0 0 1 Cd59
Time in closed arm before self-admin 3.4 1 0 0 0 1 Cd59
Time to tail flick, vehicle, before self-admin 5.1 1 0 0 0 1 Cd59
Time to tail flick, vehicle, after self-admin 12.1 1 0 0 0 1 Cd59
Time to tail flick, test, before self-admin 7.4 1 0 0 0 1 Cd59
Ambulatory time before self-admin 5.2 1 0 0 0 1 Cd59
Ambulatory time after self-admin 9.1 1 0 0 0 1 Cd59
Total heroin consumption 5.0 1 0 0 0 1 Cd59
Area under the delay curve 3.9 1 0 0 0 1 Cd59
Delay discount exponential model param 5.1 1 0 0 0 1 Cd59
Delay discount hyperbolic model param 5.0 1 0 0 0 1 Cd59
Fecal boli incidents, locomotor time 1 8.3 1 0 0 0 1 Cd59
Change in fecal boli incidents, locomotor task 17.1 1 0 0 0 1 Cd59
Bouts of movement, locomotor time 1 7.3 1 0 0 0 1 Cd59
Total resting periods, locomotor time 1 3.8 1 0 0 0 1 Cd59
Rest time, locomotor task time 1 6.0 1 0 0 0 1 Cd59
Vertical activity count, locomotor time 1 6.5 1 0 0 0 1 Cd59
Bouts of movement, locomotor time 2 17.4 1 0 0 0 1 Cd59
Total resting periods, locomotor time 2 15.7 1 0 0 0 1 Cd59
Run reversals in cocaine runway, females 15.2 1 0 0 0 1 Cd59
Run reversals in cocaine runway, males 8.6 1 0 0 0 1 Cd59
K content in liver 7.2 1 0 0 0 1 Cd59
Mg content in liver 5.6 1 0 0 0 1 Cd59

chisq ratio: Average Chi2 statistic for the selected genes in the secondary trait, divided by the average statistic for all genes in the secondary trait. # genes+: Shared significant genes at Bonferroni correction. # genes++: Shared significant genes at transcriptome-wide significance. % genes++: Number of [++] genes as a percentage of primary trait’s total joint genes. corr: Correlation of effect sizes across the [+] genes.

Associations by panel

tissue modality # hits % hits/tests avg chisq
Adipose alternative polyA 0 0.000 1.07
Adipose alternative TSS 0 0.000 1.15
Adipose gene expression 0 0.000 1.10
Adipose isoform ratio 1 0.035 1.12
Adipose intron excision ratio 0 0.000 1.04
Adipose mRNA stability 0 0.000 1.11
BLA alternative polyA 0 0.000 1.11
BLA alternative TSS 0 0.000 1.02
BLA gene expression 0 0.000 1.11
BLA isoform ratio 0 0.000 1.08
BLA intron excision ratio 0 0.000 1.05
BLA mRNA stability 0 0.000 1.09
Brain alternative polyA 0 0.000 1.09
Brain alternative TSS 0 0.000 1.04
Brain gene expression 0 0.000 1.10
Brain isoform ratio 0 0.000 1.12
Brain intron excision ratio 0 0.000 1.06
Brain mRNA stability 0 0.000 1.09
Eye alternative polyA 0 0.000 1.10
Eye alternative TSS 0 0.000 1.10
Eye gene expression 0 0.000 1.12
Eye isoform ratio 0 0.000 1.09
Eye intron excision ratio 0 0.000 1.04
Eye mRNA stability 0 0.000 1.23
IL alternative polyA 0 0.000 1.06
IL alternative TSS 0 0.000 1.17
IL gene expression 0 0.000 1.12
IL isoform ratio 0 0.000 1.10
IL intron excision ratio 0 0.000 1.14
IL mRNA stability 0 0.000 1.15
LHb alternative polyA 0 0.000 1.11
LHb alternative TSS 0 0.000 1.16
LHb gene expression 0 0.000 1.11
LHb isoform ratio 0 0.000 1.07
LHb intron excision ratio 0 0.000 1.02
LHb mRNA stability 0 0.000 1.12
Liver alternative polyA 0 0.000 0.95
Liver alternative TSS 0 0.000 1.16
Liver gene expression 0 0.000 1.10
Liver isoform ratio 0 0.000 1.12
Liver intron excision ratio 0 0.000 1.13
Liver mRNA stability 0 0.000 1.11
NAcc alternative polyA 0 0.000 1.06
NAcc alternative TSS 0 0.000 1.13
NAcc gene expression 0 0.000 1.10
NAcc isoform ratio 0 0.000 1.09
NAcc intron excision ratio 0 0.000 1.04
NAcc mRNA stability 0 0.000 1.11
OFC alternative polyA 0 0.000 1.06
OFC alternative TSS 0 0.000 1.08
OFC gene expression 0 0.000 1.14
OFC isoform ratio 0 0.000 1.11
OFC intron excision ratio 0 0.000 1.01
OFC mRNA stability 0 0.000 1.13
PL alternative polyA 0 0.000 1.11
PL alternative TSS 0 0.000 1.06
PL gene expression 0 0.000 1.11
PL isoform ratio 0 0.000 1.12
PL intron excision ratio 0 0.000 1.04
PL mRNA stability 0 0.000 1.12

avg chisq: Average Chi2 (squared Z-score) across all models in this panel for this trait.