Hub : Traits

Intermittent access terminal intake (last 3 days)

Intermittent access terminal intake (last 3 days)

Tags: Behavior · Intermittent access · Cocaine

Project: p50_paul_meyer_2020

4 loci · 4 genes with independent associations · 4 total associated genes

Significant Loci

#	Chr	Start pos	End pos	# assoc genes	# joint models	Best TWAS P	Best GWAS P	Cond GWAS P	Joint genes
1	chr4	95890735	97085238	1	1	2.87e-10	2.74e-01	2.36e-59	Serbp1
2	chr7	14449451	15768722	1	1	1.33e-15	2.96e-01	1.00e+00	LOC102551633
3	chr8	33211184	34601262	1	1	4.16e-12	3.65e-01	2.20e-08	Ddx25
4	chr9	75969545	77365260	1	1	1.08e-07	1.95e-01	1.00e+00	Zfand2b

Pleiotropic Associations

Trait	Chi2 ratio	# genes+	# genes++	% genes++	Corr	Corr P	Genes
BMI with tail	8.42	1	1	25	0	1.00e+00	Zfand2b
BMI without tail	20.97	3	1	25	0	1.00e+00	Ddx25 Serbp1 Zfand2b
Epididymis fat weight	111.28	1	1	25	0	1.00e+00	Zfand2b
Heart weight	71.7	1	1	25	0	1.00e+00	Zfand2b
Left kidney weight	27.22	1	1	25	0	1.00e+00	Zfand2b
Right kidney weight	31.41	2	1	25	0	1.00e+00	Serbp1 Zfand2b
Tail length	44.85	3	1	25	0	1.00e+00	Ddx25 Serbp1 Zfand2b
Length with tail	3.96	2	0	0	0	1.00e+00	Serbp1 Zfand2b
Length without tail	41.28	2	1	25	0	1.00e+00	Ddx25 Zfand2b
Liver weight, left	7.79	1	0	0	0	1.00e+00	Serbp1
Liver weight, right	17.57	1	1	25	0	1.00e+00	Zfand2b
Parametrial fat weight	9.99	1	0	0	0	1.00e+00	Zfand2b
Retroperitoneal fat weight	5.34	2	0	0	0	1.00e+00	Serbp1 Zfand2b
Intraocular pressure	28.59	2	1	25	0	1.00e+00	Serbp1 Zfand2b
Number of licking bursts	32.5	1	1	25	0	1.00e+00	Zfand2b
Food consumed during 24 hour testing period	15.78	1	0	0	0	1.00e+00	Zfand2b
Times rat made contact with spout	9.25	1	0	0	0	1.00e+00	Zfand2b
Mean time between licks in bursts	9.22	1	0	0	0	1.00e+00	Zfand2b
Mean num. licks in bursts	18.13	1	0	0	0	1.00e+00	Zfand2b
Std. dev. time between licks in bursts	12.12	1	0	0	0	1.00e+00	Zfand2b
Water consumed over 24 hours	34.33	1	1	25	0	1.00e+00	Zfand2b
Patch foraging indifference point 0 sec	9.77	2	0	0	0	1.00e+00	LOC102551633 Zfand2b
Patch foraging indifference point AUC	18.18	2	1	25	0	1.00e+00	Serbp1 Zfand2b
Indifference point function ln k	54.42	1	1	25	0	1.00e+00	Zfand2b
Indifference point function log k	54.42	1	1	25	0	1.00e+00	Zfand2b
Patch foraging total patch changes 0 sec	15.36	2	1	25	0	1.00e+00	LOC102551633 Zfand2b
Patch foraging total patch changes 18 sec	29.61	2	1	25	0	1.00e+00	Serbp1 Zfand2b
Patch foraging total patch changes 24 sec	77.61	1	1	25	0	1.00e+00	Zfand2b
Patch foraging total patch changes 6 sec	12.61	3	1	25	0	1.00e+00	LOC102551633 Serbp1 Zfand2b
Patch foraging time to switch 0 sec	33.47	1	1	25	0	1.00e+00	Zfand2b
Patch foraging water rate 0 sec	22.99	2	1	25	0	1.00e+00	Serbp1 Zfand2b
Patch foraging water rate 12 sec	36.8	2	1	25	0	1.00e+00	Serbp1 Zfand2b
Patch foraging water rate 18 sec	7.63	2	0	0	0	1.00e+00	Serbp1 Zfand2b
Patch foraging water rate 24 sec	12.61	1	0	0	0	1.00e+00	Zfand2b
Patch foraging water rate 6 sec	35.43	1	1	25	0	1.00e+00	Zfand2b
Locomotor activity	7.02	3	0	0	0	1.00e+00	Ddx25 LOC102551633 Zfand2b
Locomotor testing distance	18.62	3	1	25	0	1.00e+00	Ddx25 LOC102551633 Zfand2b
Locomotor testing rearing	99.51	1	1	25	0	1.00e+00	Zfand2b
Light reinforcement 1	13.88	2	1	25	0	1.00e+00	Serbp1 Zfand2b
Light reinforcement 2	6.81	2	0	0	0	1.00e+00	Serbp1 Zfand2b
Reaction time number correct	114.79	1	1	25	0	1.00e+00	Zfand2b
Reaction time mean minus median	179.03	1	1	25	0	1.00e+00	Zfand2b
Reaction time mean minus median AUC	232.47	1	1	25	0	1.00e+00	Zfand2b
Reaction time num false alarms	5.7	1	0	0	0	1.00e+00	Zfand2b
Reaction time num false alarms AUC	27.43	1	1	25	0	1.00e+00	Zfand2b
Reaction time trials correct on left	114.79	1	1	25	0	1.00e+00	Zfand2b
Reaction time trials on left	106.69	1	1	25	0	1.00e+00	Zfand2b
Reaction time mean	20.45	2	1	25	0	1.00e+00	Ddx25 Zfand2b
Reaction time mean AUC	33.75	1	1	25	0	1.00e+00	Zfand2b
Median of all reaction times	17.65	1	0	0	0	1.00e+00	Zfand2b
Reaction time omissions	25.68	2	1	25	0	1.00e+00	Serbp1 Zfand2b
Reaction time premature initiations	24.11	2	1	25	0	1.00e+00	Serbp1 Zfand2b
Std. dev. reaction times	72.92	1	1	25	0	1.00e+00	Zfand2b
Reaction time trials completed	106.69	1	1	25	0	1.00e+00	Zfand2b
Reaction time trials AUC	108.76	1	1	25	0	1.00e+00	Zfand2b
Social response proportion	6.01	1	0	0	0	1.00e+00	Zfand2b
Cocaine response after cond. corrected	12.71	1	0	0	0	1.00e+00	Zfand2b
Cocaine response after cond. not corrected	10.73	1	0	0	0	1.00e+00	Zfand2b
Saline control response	8.43	1	0	0	0	1.00e+00	Zfand2b
Condit. Reinf. lever presses	5.55	1	0	0	0	1.00e+00	Zfand2b
Conditioned reinforcement - actives	79.41	2	1	25	0	1.00e+00	LOC102551633 Zfand2b
Conditioned reinforcement - inactives	52.11	3	1	25	0	1.00e+00	Ddx25 LOC102551633 Zfand2b
Conditioned locomotion	25.36	3	1	25	0	1.00e+00	LOC102551633 Serbp1 Zfand2b
Intermittent access intake day 1-15 change	117.88	2	2	50	0	1.00e+00	Ddx25 Zfand2b
Intermittent access intake escalation	79.34	2	2	50	0	1.00e+00	Ddx25 Zfand2b
Intermittent access intake escalation 2	23.26	2	1	25	0	1.00e+00	Ddx25 LOC102551633
Intermitt. access day 1 inactive lever presses	97.66	2	2	50	0	1.00e+00	Ddx25 Zfand2b
Intermitt. access day 15 inactive lever presses	167.57	2	2	50	0	1.00e+00	Ddx25 Zfand2b
Intermitt. access escalation Index	36.25	2	1	25	0	1.00e+00	Ddx25 LOC102551633
Intermittent access day 1 total infusions	34.11	3	1	25	0	1.00e+00	LOC102551633 Serbp1 Zfand2b
Intermittent access day 15 total infusions	24.19	4	2	50	0.86	1.41e-01	Ddx25 LOC102551633 Serbp1 Zfand2b
Intermittent access total infusions	16.05	3	1	25	0	1.00e+00	Ddx25 LOC102551633 Serbp1
Intermittent access day 1 locomotion	26.47	1	1	25	0	1.00e+00	Zfand2b
Intermittent access day 15 total locomotion	62.98	2	2	50	0	1.00e+00	LOC102551633 Zfand2b
Intermittent access total locomotion	12.69	2	0	0	0	1.00e+00	LOC102551633 Zfand2b
Intermittent access standard deviation	229.02	2	1	25	0	1.00e+00	Ddx25 Zfand2b
Cocaine induced anxiety	69.01	2	1	25	0	1.00e+00	Ddx25 Zfand2b
Baseline Anxiety	393.92	1	1	25	0	1.00e+00	Zfand2b
Lifetime Intake	23.07	3	1	25	0	1.00e+00	Ddx25 LOC102551633 Serbp1
Incentive Sensitization - Responses	112.34	3	1	25	0	1.00e+00	Ddx25 LOC102551633 Zfand2b
Incentive Sensitization - Breakpoint	109.55	3	1	25	0	1.00e+00	Ddx25 LOC102551633 Zfand2b
Progressive ratio test 1 active lever presses	18.76	4	1	25	0.95	5.17e-02	Ddx25 LOC102551633 Serbp1 Zfand2b
Progressive ratio test 1 breakpoint	22.99	4	2	50	0.97	3.50e-02	Ddx25 LOC102551633 Serbp1 Zfand2b
Progressive ratio test 1 inactive lever presses	18.49	3	1	25	0	1.00e+00	Ddx25 LOC102551633 Serbp1
Progressive ratio test 2 active lever presses	45.03	3	1	25	0	1.00e+00	Ddx25 Serbp1 Zfand2b
Progressive ratio test 2 breakpoint	45.21	3	1	25	0	1.00e+00	Ddx25 Serbp1 Zfand2b
Progressive ratio test 2 inactive lever presses	32.67	4	2	50	0.9	1.03e-01	Ddx25 LOC102551633 Serbp1 Zfand2b
Total sessions with >9 infusions	29.51	2	1	25	0	1.00e+00	Ddx25 Serbp1
Short access day 1 total inactive lever presses	26.77	3	1	25	0	1.00e+00	LOC102551633 Serbp1 Zfand2b
Short access day 10 total inactive lever presses	31.81	3	2	50	0	1.00e+00	LOC102551633 Serbp1 Zfand2b
Short access day 1 total infusions	46.94	3	2	50	0	1.00e+00	Ddx25 LOC102551633 Serbp1
Short access day 10 total infusions	31.95	2	2	50	0	1.00e+00	Ddx25 LOC102551633
Short access total infusions	36.1	3	2	50	0	1.00e+00	Ddx25 LOC102551633 Serbp1
Short access day 1 locomotion	53.28	3	1	25	0	1.00e+00	LOC102551633 Serbp1 Zfand2b
Short access day 10 total locomotion	221.92	2	1	25	0	1.00e+00	Ddx25 Zfand2b
Short access total locomotion	209.96	1	1	25	0	1.00e+00	Zfand2b
Compulsive drug intake	40.41	2	1	25	0	1.00e+00	Serbp1 Zfand2b
One hour access (0.3 mA shock)	46.47	2	1	25	0	1.00e+00	Ddx25 Zfand2b
One hour access (shock baseline)	23.24	2	1	25	0	1.00e+00	Ddx25 LOC102551633
Number of responses in last shaping day	30.62	4	2	50	0.86	1.45e-01	Ddx25 LOC102551633 Serbp1 Zfand2b
Locomotion velocity, session 7	6.12	1	0	0	0	1.00e+00	Serbp1
Degree of sensitization distance	11.08	1	0	0	0	1.00e+00	LOC102551633
Pavlov. Cond. lever latency	5.45	1	0	0	0	1.00e+00	LOC102551633
Pavlov. Cond. lever contacts	5.74	1	0	0	0	1.00e+00	LOC102551633
Bone: cortical area	7.52	1	0	0	0	1.00e+00	Ddx25
Bone: cortical thickness	4.39	1	0	0	0	1.00e+00	Ddx25
Bone: cortical thickness	5.77	1	0	0	0	1.00e+00	Ddx25
Bone: elastic displacement	5.56	1	0	0	0	1.00e+00	Zfand2b
Bone: final force	4.62	2	0	0	0	1.00e+00	Ddx25 LOC102551633
Bone: final moment	4.65	1	0	0	0	1.00e+00	Ddx25
Bone: maximum force	5.29	2	0	0	0	1.00e+00	Ddx25 LOC102551633
Bone: maximum moment	5.84	1	0	0	0	1.00e+00	Ddx25
Bone: minimum diameter	3.6	1	0	0	0	1.00e+00	Ddx25
Bone: periosteal estimation	3.75	1	0	0	0	1.00e+00	Ddx25
Bone: stiffness	4.85	2	0	0	0	1.00e+00	Ddx25 LOC102551633
Distance traveled before self-admin	35.02	2	1	25	0	1.00e+00	Ddx25 LOC102551633
Distance traveled after self-admin	22.53	3	1	25	0	1.00e+00	Ddx25 LOC102551633 Zfand2b
Delta time in closed arm before/after self-admin	10.9	1	0	0	0	1.00e+00	Serbp1
Delta time in open arm before/after self-admin	25.12	2	0	0	0	1.00e+00	Serbp1 Zfand2b
Diff in mean of infusions in LGA sessions	18.85	1	0	0	0	1.00e+00	Serbp1
Extinction: sum of active levers before priming	24.99	2	0	0	0	1.00e+00	Ddx25 LOC102551633
Active lever presses in extinction session 6	21.66	3	1	25	0	1.00e+00	Ddx25 Serbp1 Zfand2b
Delta distance traveled before/after self-admin	6.76	1	0	0	0	1.00e+00	Ddx25
Delta ambulatory time before/after self-admin	11.29	3	0	0	0	1.00e+00	Ddx25 LOC102551633 Zfand2b
Time in closed arm before self-admin	28.67	2	1	25	0	1.00e+00	Serbp1 Zfand2b
Time in closed arm after self-admin	7.59	2	0	0	0	1.00e+00	LOC102551633 Serbp1
Time in open arm before self-admin	26.71	2	1	25	0	1.00e+00	LOC102551633 Zfand2b
Time in open arm after self-admin	5.82	1	0	0	0	1.00e+00	LOC102551633
Sum of active levers in priming session hrs 5-6	11.56	3	0	0	0	1.00e+00	LOC102551633 Serbp1 Zfand2b
Time to tail flick, vehicle, before self-admin	25.9	3	1	25	0	1.00e+00	Ddx25 LOC102551633 Serbp1
Time to tail flick, vehicle, after self-admin	59.44	3	3	75	0	1.00e+00	LOC102551633 Serbp1 Zfand2b
Time to tail flick, test, before self-admin	10.68	1	0	0	0	1.00e+00	Zfand2b
Delta time to tail flick, vehicle, before/after SA	69.03	3	2	50	0	1.00e+00	LOC102551633 Serbp1 Zfand2b
Ambulatory time before self-admin	21.67	3	1	25	0	1.00e+00	Ddx25 LOC102551633 Zfand2b
Ambulatory time after self-admin	17.31	2	0	0	0	1.00e+00	LOC102551633 Serbp1
Total heroin consumption	16.8	3	1	25	0	1.00e+00	Ddx25 LOC102551633 Serbp1
Area under the delay curve	31.15	1	1	25	0	1.00e+00	Zfand2b
Delay disc. indifference point, 0s delay	5.71	1	0	0	0	1.00e+00	Zfand2b
Delay disc. indifference point, 16s delay	69.03	1	1	25	0	1.00e+00	Zfand2b
Delay disc. indifference point, 24s delay	27.43	1	0	0	0	1.00e+00	Zfand2b
Delay disc. indifference point, 8s delay	74.24	1	1	25	0	1.00e+00	Zfand2b
Delay discount exponential model param	16.14	1	0	0	0	1.00e+00	Zfand2b
Delay discount hyperbolic model param	15.89	1	0	0	0	1.00e+00	Zfand2b
Fecal boli incidents, locomotor time 1	176.47	1	1	25	0	1.00e+00	Zfand2b
Change in fecal boli incidents, locomotor task	13.85	1	0	0	0	1.00e+00	Serbp1
Time >=10cm from walls, locomotor time 1	79.04	1	1	25	0	1.00e+00	Zfand2b
Bouts of movement, locomotor time 1	6.19	1	0	0	0	1.00e+00	Zfand2b
Rest time, locomotor task time 1	14.1	2	0	0	0	1.00e+00	Serbp1 Zfand2b
Vertical activity count, locomotor time 1	54.87	2	1	25	0	1.00e+00	Serbp1 Zfand2b
Bouts of movement, locomotor time 2	23.9	1	0	0	0	1.00e+00	Zfand2b
Total resting periods, locomotor time 2	36.28	1	1	25	0	1.00e+00	Zfand2b
Rest time, locomotor task time 2	44.91	1	1	25	0	1.00e+00	Zfand2b
Distance moved, locomotor task time 2	83.87	1	1	25	0	1.00e+00	Zfand2b
Vertical activity count, locomotor time 2	9.97	2	0	0	0	1.00e+00	Serbp1 Zfand2b
Weight adjusted by age	9.91	1	0	0	0	1.00e+00	Zfand2b
Seeking ratio, delayed vs. immediate footshock	8.02	3	0	0	0	1.00e+00	LOC102551633 Serbp1 Zfand2b
Locomotion in novel chamber post-restriction	16.14	2	0	0	0	1.00e+00	Serbp1 Zfand2b
Food seeking constrained by brief footshock	14.98	1	0	0	0	1.00e+00	Zfand2b
Run reversals in cocaine runway, females	36.45	1	1	25	0	1.00e+00	Zfand2b
Run reversals in cocaine runway, males	8.37	1	0	0	0	1.00e+00	Ddx25
Latency to leave start box in cocaine runway	20.07	2	1	25	0	1.00e+00	Ddx25 Zfand2b
Latency to leave start box in cocaine runway, F	31.9	1	1	25	0	1.00e+00	Zfand2b
Latency to leave start box in cocaine runway, M	10.76	1	0	0	0	1.00e+00	Ddx25
Co content in liver	12.69	1	0	0	0	1.00e+00	LOC102551633
Fe content in liver	7.51	1	0	0	0	1.00e+00	LOC102551633
K content in liver	11.66	1	0	0	0	1.00e+00	LOC102551633
Na content in liver	44.6	1	1	25	0	1.00e+00	LOC102551633
Rb content in liver	16.75	1	0	0	0	1.00e+00	LOC102551633
Se content in liver	12.37	1	0	0	0	1.00e+00	LOC102551633
Sr content in liver	9.74	1	0	0	0	1.00e+00	Ddx25

Associations by panel

Tissue	RNA modality	# hits	% hits/tests	Avg chisq
Adipose	alternative polyA	0	0	1.05
Adipose	alternative TSS	0	0	1.08
Adipose	gene expression	1	0	1.1
Adipose	isoform ratio	0	0	1.08
Adipose	intron excision ratio	0	0	1.02
Adipose	mRNA stability	0	0	1.11
BLA	alternative polyA	0	0	1.15
BLA	alternative TSS	0	0	1.07
BLA	gene expression	0	0	1.1
BLA	isoform ratio	0	0	1.05
BLA	intron excision ratio	0	0	1.01
BLA	mRNA stability	0	0	1.12
Brain	alternative polyA	0	0	1.1
Brain	alternative TSS	0	0	1.06
Brain	gene expression	0	0	1.09
Brain	isoform ratio	0	0	1.09
Brain	intron excision ratio	0	0	1.09
Brain	mRNA stability	0	0	1.12
Eye	alternative polyA	0	0	1.05
Eye	alternative TSS	0	0	1.05
Eye	gene expression	0	0	1.09
Eye	isoform ratio	0	0	1.07
Eye	intron excision ratio	0	0	1.01
Eye	mRNA stability	0	0	1.14
IL	alternative polyA	0	0	1.14
IL	alternative TSS	0	0	1.12
IL	gene expression	0	0	1.1
IL	isoform ratio	0	0	1.11
IL	intron excision ratio	0	0	1.09
IL	mRNA stability	0	0	1.15
LHb	alternative polyA	0	0	1.1
LHb	alternative TSS	0	0	1.36
LHb	gene expression	0	0	1.09
LHb	isoform ratio	0	0	1.22
LHb	intron excision ratio	0	0	0.97
LHb	mRNA stability	0	0	1.12
Liver	alternative polyA	0	0	1.12
Liver	alternative TSS	0	0	1.14
Liver	gene expression	0	0	1.1
Liver	isoform ratio	1	0	1.16
Liver	intron excision ratio	0	0	1.12
Liver	mRNA stability	0	0	1.11
NAcc	alternative polyA	0	0	1.09
NAcc	alternative TSS	0	0	1.04
NAcc	gene expression	0	0	1.11
NAcc	isoform ratio	0	0	1.05
NAcc	intron excision ratio	0	0	1.06
NAcc	mRNA stability	0	0	1.12
OFC	alternative polyA	0	0	1.2
OFC	alternative TSS	0	0	1.16
OFC	gene expression	0	0	1.09
OFC	isoform ratio	0	0	1.16
OFC	intron excision ratio	0	0	1.02
OFC	mRNA stability	0	0	1.09
PL	alternative polyA	0	0	1.1
PL	alternative TSS	0	0	1.08
PL	gene expression	0	0	1.1
PL	isoform ratio	0	0	1.12
PL	intron excision ratio	1	0	1.07
PL	mRNA stability	0	0	1.14
pVTA	alternative polyA	0	0	1.18
pVTA	alternative TSS	0	0	1.13
pVTA	gene expression	0	0	1.1
pVTA	isoform ratio	0	0	1.12
pVTA	intron excision ratio	0	0	1.07
pVTA	mRNA stability	0	0	1.18
RMTg	alternative polyA	1	0.2	1.23
RMTg	alternative TSS	0	0	0.96
RMTg	gene expression	0	0	1.08
RMTg	isoform ratio	0	0	1.05
RMTg	intron excision ratio	0	0	1.06
RMTg	mRNA stability	0	0	1.26