Short access day 1 total inactive lever presses

Tags: Behavior · Cocaine · Short access

Project: p50_paul_meyer_2020

2 loci · 2 genes with independent associations · 2 total associated genes

Significant Loci

#	Chr	Start pos	End pos	# assoc genes	# joint models	Best TWAS P	Best GWAS P	Cond GWAS P	Joint genes
1	chr1	79485178	80785451	1	1	4.69e-08	3.85e-02	4.95e-02	Zfp575
2	chr4	95890735	97085238	1	1	3.74e-14	2.21e-01	6.39e-14	Serbp1

Pleiotropic Associations

Trait	Chi² ratio	# genes⁺	# genes⁺⁺	% genes⁺⁺	Corr P	Genes
BMI without tail	3.89	2	0	0	1e+00	Serbp1 Zfp575
Left kidney weight	2.5	1	0	0	1e+00	Zfp575
Right kidney weight	5.42	2	0	0	1e+00	Serbp1 Zfp575
Tail length	2.64	2	0	0	1e+00	Serbp1 Zfp575
Length with tail	3.13	1	0	0	1e+00	Serbp1
Length without tail	4.31	1	0	0	1e+00	Zfp575
Liver weight, left	7.79	1	0	0	1e+00	Serbp1
Parametrial fat weight	2.76	1	0	0	1e+00	Zfp575
Retroperitoneal fat weight	3.15	1	0	0	1e+00	Serbp1
Intraocular pressure	5.48	1	0	0	1e+00	Serbp1
Patch foraging indifference point AUC	12.17	1	0	0	1e+00	Serbp1
Patch foraging total patch changes 18 sec	10.94	1	0	0	1e+00	Serbp1
Patch foraging total patch changes 24 sec	4.53	1	0	0	1e+00	Zfp575
Patch foraging total patch changes 6 sec	7.52	1	0	0	1e+00	Serbp1
Patch foraging water rate 0 sec	6.51	1	0	0	1e+00	Serbp1
Patch foraging water rate 12 sec	4.1	1	0	0	1e+00	Serbp1
Patch foraging water rate 18 sec	5.55	1	0	0	1e+00	Serbp1
Patch foraging water rate 6 sec	4.97	1	0	0	1e+00	Zfp575
Locomotor activity	3.36	1	0	0	1e+00	Serbp1
Light reinforcement 1	8.51	1	0	0	1e+00	Serbp1
Light reinforcement 2	7.05	1	0	0	1e+00	Serbp1
Reaction time number correct	4.8	1	0	0	1e+00	Zfp575
Reaction time trials correct on left	4.8	1	0	0	1e+00	Zfp575
Reaction time trials on left	4.9	1	0	0	1e+00	Zfp575
Reaction time mean AUC	4.32	1	0	0	1e+00	Serbp1
Reaction time omissions	4.8	1	0	0	1e+00	Serbp1
Reaction time premature initiations	6.63	1	0	0	1e+00	Serbp1
Reaction time trials completed	4.9	1	0	0	1e+00	Zfp575
Reaction time trials AUC	4.63	1	0	0	1e+00	Zfp575
Social responses	4.22	1	0	0	1e+00	Zfp575
Social time	4.57	1	0	0	1e+00	Serbp1
Conditioned reinforcement - actives	5.59	1	0	0	1e+00	Zfp575
Conditioned reinforcement - inactives	4.8	1	0	0	1e+00	Zfp575
Conditioned locomotion	6.92	2	0	0	1e+00	Serbp1 Zfp575
Intermitt. access day 15 inactive lever presses	5.48	1	0	0	1e+00	Serbp1
Intermittent access day 1 total infusions	11.42	1	0	0	1e+00	Serbp1
Intermittent access day 15 total infusions	12.79	2	0	0	1e+00	Serbp1 Zfp575
Intermittent access terminal intake (last 3 days)	23.43	2	1	50	1e+00	Serbp1 Zfp575
Intermittent access total infusions	11.53	2	0	0	1e+00	Serbp1 Zfp575
Intermittent access day 1 locomotion	5.4	1	0	0	1e+00	Zfp575
Intermittent access total locomotion	11.21	1	0	0	1e+00	Zfp575
Intermittent access standard deviation	7.36	2	0	0	1e+00	Serbp1 Zfp575
Lifetime Intake	10.1	2	0	0	1e+00	Serbp1 Zfp575
Incentive Sensitization - Responses	22.65	1	0	0	1e+00	Zfp575
Incentive Sensitization - Breakpoint	27	1	1	50	1e+00	Zfp575
Progressive ratio test 1 active lever presses	22.83	1	0	0	1e+00	Serbp1
Progressive ratio test 1 breakpoint	29.2	1	1	50	1e+00	Serbp1
Progressive ratio test 1 inactive lever presses	11.37	1	0	0	1e+00	Serbp1
Progressive ratio test 2 active lever presses	9.25	2	0	0	1e+00	Serbp1 Zfp575
Progressive ratio test 2 breakpoint	9.78	2	0	0	1e+00	Serbp1 Zfp575
Progressive ratio test 2 inactive lever presses	6.34	2	0	0	1e+00	Serbp1 Zfp575
Total sessions with >9 infusions	25.9	2	1	50	1e+00	Serbp1 Zfp575
Short access day 10 total inactive lever presses	35.25	1	1	50	1e+00	Serbp1
Short access day 1 total infusions	12.06	2	0	0	1e+00	Serbp1 Zfp575
Short access total infusions	9.9	1	0	0	1e+00	Serbp1
Short access day 1 locomotion	8.45	1	0	0	1e+00	Serbp1
Compulsive drug intake	13.27	2	0	0	1e+00	Serbp1 Zfp575
One hour access (0.3 mA shock)	46.44	1	1	50	1e+00	Zfp575
One hour access (shock baseline)	26	1	1	50	1e+00	Zfp575
Number of responses in last shaping day	10.18	2	0	0	1e+00	Serbp1 Zfp575
Locomotion velocity, session 7	6.12	1	0	0	1e+00	Serbp1
Distance traveled before self-admin	16.57	1	0	0	1e+00	Zfp575
Distance traveled after self-admin	9.14	1	0	0	1e+00	Zfp575
Delta time in closed arm before/after self-admin	10.9	1	0	0	1e+00	Serbp1
Delta time in open arm before/after self-admin	23.57	1	0	0	1e+00	Serbp1
Diff in mean of infusions in LGA sessions	18.85	1	0	0	1e+00	Serbp1
Extinction: sum of active levers before priming	17.14	1	0	0	1e+00	Zfp575
Active lever presses in extinction session 6	18.99	2	1	50	1e+00	Serbp1 Zfp575
Time in closed arm before self-admin	13.02	1	0	0	1e+00	Serbp1
Time in closed arm after self-admin	6.26	2	0	0	1e+00	Serbp1 Zfp575
Time in open arm before self-admin	21.1	1	0	0	1e+00	Zfp575
Sum of active levers in priming session hrs 5-6	8.73	1	0	0	1e+00	Serbp1
Time to tail flick, vehicle, before self-admin	14.83	1	0	0	1e+00	Serbp1
Time to tail flick, vehicle, after self-admin	29.99	2	1	50	1e+00	Serbp1 Zfp575
Time to tail flick, test, before self-admin	8.16	2	0	0	1e+00	Serbp1 Zfp575
Delta time to tail flick, vehicle, before/after SA	9.85	1	0	0	1e+00	Serbp1
Ambulatory time before self-admin	8.91	1	0	0	1e+00	Zfp575
Ambulatory time after self-admin	12.12	2	0	0	1e+00	Serbp1 Zfp575
Total heroin consumption	10.71	1	0	0	1e+00	Serbp1
Change in fecal boli incidents, locomotor task	9.76	2	0	0	1e+00	Serbp1 Zfp575
Rest time, locomotor task time 1	16.73	1	0	0	1e+00	Serbp1
Vertical activity count, locomotor time 1	12.65	2	0	0	1e+00	Serbp1 Zfp575
Vertical activity count, locomotor time 2	6.77	1	0	0	1e+00	Serbp1
Weight adjusted by age	15.78	1	0	0	1e+00	Zfp575
Seeking ratio, delayed vs. immediate footshock	8.42	2	0	0	1e+00	Serbp1 Zfp575
Locomotion in novel chamber	6.51	1	0	0	1e+00	Zfp575
Locomotion in novel chamber post-restriction	18.24	1	0	0	1e+00	Serbp1
Food seeking constrained by brief footshock	11.04	1	0	0	1e+00	Zfp575
Latency to leave start box in cocaine runway, M	14.7	1	0	0	1e+00	Zfp575
Sr content in liver	6.24	1	0	0	1e+00	Zfp575

Associations by panel

Tissue	RNA modality	# hits	Avg chisq
Adipose	alternative polyA	0	1.03
Adipose	alternative TSS	0	1.1
Adipose	gene expression	0	1.11
Adipose	isoform ratio	0	1.08
Adipose	intron excision ratio	0	1.14
Adipose	mRNA stability	0	1.09
BLA	alternative polyA	0	1.17
BLA	alternative TSS	0	1.07
BLA	gene expression	0	1.13
BLA	isoform ratio	0	1.11
BLA	intron excision ratio	0	1.11
BLA	mRNA stability	0	1.12
Brain	alternative polyA	0	1.11
Brain	alternative TSS	0	1.12
Brain	gene expression	0	1.12
Brain	isoform ratio	0	1.16
Brain	intron excision ratio	0	1.1
Brain	mRNA stability	0	1.11
Eye	alternative polyA	0	1.4
Eye	alternative TSS	0	0.96
Eye	gene expression	0	1.25
Eye	isoform ratio	0	1.11
Eye	intron excision ratio	0	1.04
Eye	mRNA stability	0	1.17
IL	alternative polyA	0	1.24
IL	alternative TSS	0	1
IL	gene expression	0	1.12
IL	isoform ratio	0	1.16
IL	intron excision ratio	0	1.07
IL	mRNA stability	0	1.19
LHb	alternative polyA	0	1.15
LHb	alternative TSS	0	1.21
LHb	gene expression	0	1.12
LHb	isoform ratio	0	1.18
LHb	intron excision ratio	0	1.11
LHb	mRNA stability	0	1.22
Liver	alternative polyA	0	1.06
Liver	alternative TSS	0	1.11
Liver	gene expression	0	1.13
Liver	isoform ratio	1	1.18
Liver	intron excision ratio	0	1.05
Liver	mRNA stability	0	1.13
NAcc	alternative polyA	0	1.11
NAcc	alternative TSS	0	1.12
NAcc	gene expression	0	1.14
NAcc	isoform ratio	0	1.13
NAcc	intron excision ratio	0	1.08
NAcc	mRNA stability	0	1.12
OFC	alternative polyA	0	1.2
OFC	alternative TSS	0	1.06
OFC	gene expression	0	1.1
OFC	isoform ratio	0	1.13
OFC	intron excision ratio	0	1.06
OFC	mRNA stability	0	1.14
PL	alternative polyA	0	1.14
PL	alternative TSS	0	1.07
PL	gene expression	0	1.12
PL	isoform ratio	0	1.17
PL	intron excision ratio	0	1.13
PL	mRNA stability	1	1.17
pVTA	alternative polyA	0	1.15
pVTA	alternative TSS	0	1.12
pVTA	gene expression	0	1.14
pVTA	isoform ratio	0	1.17
pVTA	intron excision ratio	0	1.1
pVTA	mRNA stability	0	1.2
RMTg	alternative polyA	0	1.13
RMTg	alternative TSS	0	1
RMTg	gene expression	0	1.15
RMTg	isoform ratio	0	1.07
RMTg	intron excision ratio	0	1.07
RMTg	mRNA stability	0	1.2