Hub : Traits

Short access day 1 total inactive lever presses

Tags: Behavior · Cocaine · Short access

Project: p50_paul_meyer_2020

3 significantly associated models · 3 unique genes

Significant Loci

# chr p0 p1 # assoc genes # joint models best TWAS P best SNP P cond SNP P % var exp joint genes
1 1 68581504 69974370 1 1 1.8e-07 0.063 2.6e-01 63 Syt5
2 3 2116113 2932438 1 1 1.3e-08 0.024 5.1e-21 -1628 NA
3 14 46020357 47414802 1 1 9.3e-08 0.157 1.0e+00 100 Arap2

p0: physical position of the start of the locus. p1: physical position of the end of the locus. # joint models: number of models selected by step-wise conditional analysis.

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Body weight 2.3 2 0 0 0 1 Syt5 Arap2
Epididymis fat weight 3.8 1 0 0 0 1 Arap2
Glucose 12.1 1 0 0 0 1 Syt5
Left kidney weight 2.2 1 0 0 0 1 Arap2
Right kidney weight 2.6 1 0 0 0 1 Syt5
Length without tail 3.5 2 0 0 0 1 Syt5 Arap2
Liver weight, left 10.2 1 0 0 0 1 Syt5
Liver weight, right 11.2 1 0 0 0 1 Syt5
Extensor digitorum longus weight 2.6 1 0 0 0 1 Arap2
Tibialis anterior weight 2.4 1 0 0 0 1 Syt5
Tibia length 7.5 1 0 0 0 1 Syt5
Std. dev. time between licks in bursts 22.7 1 1 33 0 1 Syt5
Indifference point 0 sec 6.3 1 0 0 0 1 Syt5
Indifference point function ln k 8.8 1 0 0 0 1 Syt5
Indifference point function log k 8.8 1 0 0 0 1 Syt5
Delay discounting total patch changes 0 sec 5.8 1 0 0 0 1 Syt5
Delay discounting total patch changes 12 sec 4.6 1 0 0 0 1 NA
Delay discounting total patch changes 24 sec 8.0 2 0 0 0 1 Syt5 NA
Delay discounting time to switch 0 sec 33.5 2 1 33 0 1 Syt5 Arap2
Delay discounting water rate 0 sec 8.8 2 0 0 0 1 Syt5 Arap2
Delay discounting water rate 12 sec 22.1 1 1 33 0 1 Syt5
Delay discounting water rate 18 sec 14.3 2 0 0 0 1 Syt5 Arap2
Delay discounting water rate 24 sec 8.0 1 0 0 0 1 Syt5
Light reinforcement 1 10.1 3 1 33 0 1 Syt5 Arap2 NA
Light reinforcement 2 21.6 1 1 33 0 1 Syt5
Reaction time number correct 4.6 1 0 0 0 1 NA
Reaction time num false alarms 11.2 1 0 0 0 1 Arap2
Reaction time num false alarms AUC 10.1 2 0 0 0 1 Syt5 Arap2
Reaction time trials correct on left 4.6 1 0 0 0 1 NA
Reaction time trials on left 4.7 1 0 0 0 1 NA
Reaction time mean 5.1 1 0 0 0 1 Syt5
Reaction time mean AUC 5.5 2 0 0 0 1 Syt5 Arap2
Median of all reaction times 7.0 1 0 0 0 1 Syt5
Reaction time omissions 5.3 1 0 0 0 1 Syt5
Reaction time false alarm rate 6.2 2 0 0 0 1 Syt5 NA
Reaction time trials completed 4.7 1 0 0 0 1 NA
Reaction time trials AUC 4.4 1 0 0 0 1 NA
Social response proportion 8.0 1 0 0 0 1 Syt5
Social time 18.1 1 0 0 0 1 Syt5
Conditioned locomotion 5.9 1 0 0 0 1 Syt5
Cocaine response after cond. corrected 18.2 1 0 0 0 1 Syt5
Cocaine response after cond. not corrected 16.4 1 0 0 0 1 Syt5
Saline control response 13.2 1 0 0 0 1 Syt5
Condit. Reinf. lever presses 9.9 1 0 0 0 1 Syt5
Pavlov. Cond. change in total contacts 5.3 2 0 0 0 1 Syt5 Arap2
Pavlov. Cond. lever contacts 5.4 1 0 0 0 1 Arap2
Pavlov. Cond. intertrial magazine entries 4.6 1 0 0 0 1 Arap2
Conditioned reinforcement - actives 22.3 1 0 0 0 1 Syt5
Conditioned reinforcement - inactives 16.8 1 0 0 0 1 Arap2
Conditioned locomotion 15.1 1 0 0 0 1 Syt5
Intermittent access intake day 1-15 change 10.9 2 0 0 0 1 Syt5 Arap2
Intermittent access intake escalation 10.8 1 0 0 0 1 Arap2
Intermittent access intake escalation 2 10.1 1 0 0 0 1 Arap2
Intermitt. access day 1 inactive lever presses 13.6 3 0 0 0 1 Syt5 Arap2 NA
Intermitt. access day 15 inactive lever presses 24.1 2 1 33 0 1 Syt5 Arap2
Intermitt. access escalation Index 19.9 2 0 0 0 1 Syt5 Arap2
Intermittent access standard deviation 9.3 1 0 0 0 1 Syt5
Post-drug Anxiety 8.1 2 0 0 0 1 Syt5 NA
Baseline Anxiety 17.8 2 1 33 0 1 Syt5 Arap2
Incentive Sensitization - Responses 6.8 1 0 0 0 1 Syt5
Incentive Sensitization - Breakpoint 8.6 1 0 0 0 1 Syt5
Progressive ratio test 1 inactive lever presses 6.2 1 0 0 0 1 NA
Short access day 10 total inactive lever presses 20.0 1 0 0 0 1 NA
Short access day 10 total locomotion 11.2 1 0 0 0 1 Syt5
Short access total locomotion 10.8 2 0 0 0 1 Syt5 Arap2
One hour access (0.3 mA shock) 5.2 1 0 0 0 1 Arap2
One hour access (shock baseline) 24.4 1 1 33 0 1 Syt5
Number of responses in last shaping day 9.8 1 0 0 0 1 Syt5
Locomotion velocity, session 1 61.5 1 1 33 0 1 Syt5
Locomotion distance, session 1 22.4 1 1 33 0 1 Syt5
Locomotion velocity, session 2 12.8 2 0 0 0 1 Syt5 Arap2
Locomotion distance, session 2 5.3 2 0 0 0 1 Syt5 NA
Locomotion distance, session 3 8.7 1 0 0 0 1 Syt5
Locomotion velocity, session 7 6.0 1 0 0 0 1 Syt5
Locomotion distance, session 7 7.9 2 0 0 0 1 Syt5 Arap2
Locomotion velocity, session 8 15.7 1 0 0 0 1 Syt5
Locomotion distance, session 8 9.2 1 0 0 0 1 Syt5
Condit. Reinf. active responses 16.4 1 0 0 0 1 Arap2
Condit. Reinf. inactive responses 15.4 1 0 0 0 1 Arap2
Incentive salience index mean 5.9 1 0 0 0 1 Arap2
Time in familiar zone, hab. session 1 12.8 1 0 0 0 1 Syt5
Total zone transitions, hab. session 1 15.2 2 1 33 0 1 Syt5 NA
Total locomotion distance, hab. session 1 19.3 1 1 33 0 1 Syt5
Locomotion velocity, hab. session 1 12.3 1 0 0 0 1 Syt5
Time in familiar zone, hab. session 2 14.1 1 0 0 0 1 Syt5
Total zone transitions, hab. session 2 7.1 2 0 0 0 1 Syt5 Arap2
Total locomotion distance, hab. session 2 10.7 1 0 0 0 1 Syt5
Locomotion velocity, hab. session 2 13.6 1 0 0 0 1 Syt5
Total zone transitions, NPP test 4.7 2 0 0 0 1 Syt5 NA
Total locomotion distance, NPP test 11.3 1 0 0 0 1 Arap2
Locomotion velocity, NPP test 10.2 1 0 0 0 1 Arap2
Pavlov. Cond. magazine entry latency 10.4 1 0 0 0 1 Syt5
Pavlov. Cond. change in total contacts 14.5 1 0 0 0 1 Arap2
Pavlov. Cond. intertrial magazine entries 16.4 2 0 0 0 1 Syt5 Arap2
Pavlov. Cond. response bias 13.4 1 0 0 0 1 Syt5
Bone: cortical porosity 7.7 1 0 0 0 1 Syt5
Bone: elastic displacement 7.7 1 0 0 0 1 Syt5
Bone: elastic work 5.8 1 0 0 0 1 Syt5
Bone: post-yield work 11.6 1 0 0 0 1 Syt5
Bone: stiffness 4.5 1 0 0 0 1 Syt5
Bone: tissue strength 13.1 1 0 0 0 1 Syt5
Bone: trabecular tissue density 8.2 1 0 0 0 1 Syt5
Distance traveled before self-admin 57.6 1 1 33 0 1 Syt5
Distance traveled after self-admin 56.6 1 1 33 0 1 Syt5
Delta time in closed arm before/after self-admin 11.6 1 0 0 0 1 NA
Delta time in open arm before/after self-admin 18.0 1 0 0 0 1 Syt5
Diff in mean of infusions in LGA sessions 20.4 1 0 0 0 1 Syt5
Extinction: sum of active levers before priming 36.5 1 1 33 0 1 Syt5
Active lever presses in extinction session 6 17.9 1 0 0 0 1 Syt5
Time in closed arm after self-admin 22.3 1 0 0 0 1 Syt5
Time in open arm after self-admin 17.1 1 0 0 0 1 Syt5
Sum of active levers in priming session hrs 5-6 17.2 1 0 0 0 1 Syt5
Time to tail flick, vehicle, before self-admin 7.0 1 0 0 0 1 Arap2
Time to tail flick, test, before self-admin 57.2 1 1 33 0 1 Syt5
Time to tail flick, test, after self-admin 7.0 2 0 0 0 1 Syt5 Arap2
Delta time to tail flick, vehicle, before/after SA 8.6 1 0 0 0 1 Syt5
Delta time to tail flick, test, before/after SA 42.4 1 1 33 0 1 Syt5
Ambulatory time before self-admin 21.2 2 1 33 0 1 Syt5 Arap2
Ambulatory time after self-admin 33.7 2 1 33 0 1 Syt5 NA
Total heroin consumption 7.8 2 0 0 0 1 Syt5 Arap2
Delay disc. indifference point, 0s delay 28.0 1 1 33 0 1 Syt5
Delay disc. indifference point, 16s delay 24.1 1 0 0 0 1 Syt5
Delay disc. indifference point, 2s delay 7.4 1 0 0 0 1 Arap2
Delay disc. indifference point, 24s delay 9.6 1 0 0 0 1 Syt5
Change in fecal boli incidents, locomotor task 15.7 2 0 0 0 1 Syt5 Arap2
Bouts of movement, locomotor time 1 31.8 2 1 33 0 1 Syt5 NA
Total resting periods, locomotor time 1 23.0 2 1 33 0 1 Syt5 NA
Vertical activity count, locomotor time 1 24.2 1 0 0 0 1 Syt5
Rest time, locomotor task time 2 9.1 1 0 0 0 1 Syt5
Vertical activity count, locomotor time 2 5.6 1 0 0 0 1 Syt5
Weight adjusted by age 8.3 1 0 0 0 1 Syt5
Seeking ratio, delayed vs. immediate footshock 29.7 1 1 33 0 1 Syt5
Locomotion in novel chamber 10.8 2 0 0 0 1 Syt5 Arap2
Locomotion in novel chamber post-restriction 22.1 1 1 33 0 1 Arap2
Progressive ratio 7.6 1 0 0 0 1 Syt5
Food seeking constrained by brief footshock 50.1 3 1 33 0 1 Syt5 Arap2 NA
Seeking ratio, punishment vs. effort 16.5 1 0 0 0 1 Syt5
Run reversals in cocaine runway, females 8.3 1 0 0 0 1 Syt5
Cd content in liver 7.2 2 0 0 0 1 Syt5 Arap2
Co content in liver 19.4 1 0 0 0 1 Syt5
Fe content in liver 6.2 1 0 0 0 1 NA
Rb content in liver 6.5 1 0 0 0 1 Syt5
Se content in liver 10.0 1 0 0 0 1 Arap2
Sr content in liver 66.7 1 1 33 0 1 Syt5
Zn content in liver 12.4 1 0 0 0 1 Syt5

chisq ratio: Average Chi2 statistic for the selected genes in the secondary trait, divided by the average statistic for all genes in the secondary trait. # genes+: Shared significant genes at Bonferroni correction. # genes++: Shared significant genes at transcriptome-wide significance. % genes++: Number of [++] genes as a percentage of primary trait’s total joint genes. corr: Correlation of effect sizes across the [+] genes.

Associations by panel

tissue modality # hits % hits/tests avg chisq
Adipose alternative polyA 0 0.000 1.1
Adipose alternative TSS 0 0.000 1.2
Adipose gene expression 0 0.000 1.1
Adipose isoform ratio 0 0.000 1.1
Adipose intron excision ratio 0 0.000 1.1
Adipose mRNA stability 0 0.000 1.1
BLA alternative polyA 0 0.000 1.0
BLA alternative TSS 0 0.000 1.0
BLA gene expression 0 0.000 1.1
BLA isoform ratio 0 0.000 1.1
BLA intron excision ratio 0 0.000 1.1
BLA mRNA stability 1 0.050 1.2
Brain alternative polyA 0 0.000 1.1
Brain alternative TSS 0 0.000 1.1
Brain gene expression 0 0.000 1.1
Brain isoform ratio 0 0.000 1.2
Brain intron excision ratio 0 0.000 1.1
Brain mRNA stability 0 0.000 1.2
Eye alternative polyA 0 0.000 1.2
Eye alternative TSS 0 0.000 1.2
Eye gene expression 0 0.000 1.2
Eye isoform ratio 0 0.000 1.1
Eye intron excision ratio 0 0.000 1.0
Eye mRNA stability 0 0.000 1.2
IL alternative polyA 0 0.000 1.0
IL alternative TSS 0 0.000 1.0
IL gene expression 0 0.000 1.1
IL isoform ratio 0 0.000 1.1
IL intron excision ratio 0 0.000 1.1
IL mRNA stability 0 0.000 1.2
LHb alternative polyA 0 0.000 1.1
LHb alternative TSS 0 0.000 1.1
LHb gene expression 0 0.000 1.1
LHb isoform ratio 0 0.000 1.1
LHb intron excision ratio 0 0.000 1.0
LHb mRNA stability 0 0.000 1.2
Liver alternative polyA 0 0.000 1.0
Liver alternative TSS 0 0.000 1.1
Liver gene expression 1 0.014 1.1
Liver isoform ratio 0 0.000 1.2
Liver intron excision ratio 0 0.000 1.1
Liver mRNA stability 0 0.000 1.1
NAcc alternative polyA 0 0.000 1.0
NAcc alternative TSS 0 0.000 1.1
NAcc gene expression 0 0.000 1.2
NAcc isoform ratio 0 0.000 1.1
NAcc intron excision ratio 0 0.000 1.1
NAcc mRNA stability 1 0.044 1.2
OFC alternative polyA 0 0.000 1.1
OFC alternative TSS 0 0.000 1.0
OFC gene expression 0 0.000 1.1
OFC isoform ratio 0 0.000 1.1
OFC intron excision ratio 0 0.000 1.2
OFC mRNA stability 0 0.000 1.2
PL alternative polyA 0 0.000 1.1
PL alternative TSS 0 0.000 1.1
PL gene expression 0 0.000 1.1
PL isoform ratio 0 0.000 1.1
PL intron excision ratio 0 0.000 1.1
PL mRNA stability 0 0.000 1.2

avg chisq: Average Chi2 (squared Z-score) across all models in this panel for this trait.