Delay disc. indifference point, 16s delay

Abnormal impulse behavior control/Impulsivity assay, delay discounting using an adjusting amount procedure: subject's calculated indifference point for all exposures/repetitions of 16s delay sessions in 11-16 week old NIH heterogeneous stock rats for males and females (MEDPC V equipment, where immediate lever with 0s delay provides choice dependent adjusting amounts starting at 75 microliter of sucrose solution and delayed lever provides 150 microliter of sucrose solution) [microliter].

Tags: Behavior · Impulsivity · Delay discounting

Project: u01_suzanne_mitchell

1 loci · 1 genes with independent associations · 1 total associated genes

Significant Loci

#	Chr	Start pos	End pos	# assoc genes	# joint models	Best TWAS P	Best GWAS P	Cond GWAS P	Joint genes
1	10	62271668	63667097	1	1	9.03e-16	1.27e-01	6.4e-22	Eral1

Pleiotropic Associations

Trait	Chi² ratio	# genes⁺	# genes⁺⁺	% genes⁺⁺	Corr P	Genes
Heart weight	3.63	1	0	0	1e+00	Eral1
Left kidney weight	1.53	1	0	0	1e+00	Eral1
Food consumed during 24 hour testing period	14.68	1	0	0	1e+00	Eral1
Times rat made contact with spout	19.64	1	0	0	1e+00	Eral1
Mean time between licks in bursts	5.57	1	0	0	1e+00	Eral1
Mean num. licks in bursts	16.6	1	0	0	1e+00	Eral1
Std. dev. time between licks in bursts	13.88	1	0	0	1e+00	Eral1
Intermittent access intake escalation 2	6.45	1	0	0	1e+00	Eral1
Intermitt. access day 1 inactive lever presses	5.81	1	0	0	1e+00	Eral1
Intermitt. access day 15 inactive lever presses	19.83	1	0	0	1e+00	Eral1
Intermittent access total locomotion	7.32	1	0	0	1e+00	Eral1
Short access day 10 total inactive lever presses	4.2	1	0	0	1e+00	Eral1
Short access day 1 total infusions	28.54	1	1	100	1e+00	Eral1
Short access total infusions	17.56	1	0	0	1e+00	Eral1
Short access day 1 locomotion	23.22	1	0	0	1e+00	Eral1
Short access total locomotion	23.77	1	0	0	1e+00	Eral1
Breakpoint value in progressive ratio session	7.34	1	0	0	1e+00	Eral1
Distance traveled before self-admin	58.43	1	1	100	1e+00	Eral1
Distance traveled after self-admin	7.49	1	0	0	1e+00	Eral1
Delta time in open arm before/after self-admin	8.04	1	0	0	1e+00	Eral1
Extinction: sum of active levers before priming	8.22	1	0	0	1e+00	Eral1
Active lever presses in extinction session 6	20.19	1	0	0	1e+00	Eral1
Delta distance traveled before/after self-admin	8.53	1	0	0	1e+00	Eral1
Delta ambulatory time before/after self-admin	37.49	1	1	100	1e+00	Eral1
Time in open arm after self-admin	10.52	1	0	0	1e+00	Eral1
Time to tail flick, vehicle, before self-admin	10.06	1	0	0	1e+00	Eral1
Time to tail flick, vehicle, after self-admin	4.88	1	0	0	1e+00	Eral1
Ambulatory time before self-admin	49.07	1	1	100	1e+00	Eral1
Ambulatory time after self-admin	6.62	1	0	0	1e+00	Eral1
Total heroin consumption	3.34	1	0	0	1e+00	Eral1
Area under the delay curve	45.55	1	1	100	1e+00	Eral1
Delay disc. indifference point, 24s delay	9.47	1	0	0	1e+00	Eral1
Delay disc. indifference point, 4s delay	6.47	1	0	0	1e+00	Eral1
Delay disc. indifference point, 8s delay	71.89	1	1	100	1e+00	Eral1
Delay discount exponential model param	36.26	1	1	100	1e+00	Eral1
Delay discount hyperbolic model param	29.71	1	1	100	1e+00	Eral1
Rest time, locomotor task time 1	15.21	1	0	0	1e+00	Eral1
Distance moved, locomotor task time 1	3.68	1	0	0	1e+00	Eral1
Time >=10cm from walls, locomotor time 2	39.82	1	1	100	1e+00	Eral1
Rest time, locomotor task time 2	5.56	1	0	0	1e+00	Eral1
Distance moved, locomotor task time 2	13.4	1	0	0	1e+00	Eral1
Vertical activity count, locomotor time 2	8.68	1	0	0	1e+00	Eral1
Weight adjusted by age	3.44	1	0	0	1e+00	Eral1
Locomotion in novel chamber post-restriction	13.53	1	0	0	1e+00	Eral1
Progressive ratio	27.88	1	1	100	1e+00	Eral1
Food seeking constrained by brief footshock	13.98	1	0	0	1e+00	Eral1
Seeking ratio, punishment vs. effort	10.23	1	0	0	1e+00	Eral1
Run reversals in cocaine runway, males	48.09	1	1	100	1e+00	Eral1
Latency to leave start box in cocaine runway	12.57	1	0	0	1e+00	Eral1
Latency to leave start box in cocaine runway, M	38.49	1	1	100	1e+00	Eral1

Associations by panel

Tissue	RNA modality	# hits	Avg chisq
Adipose	alternative polyA	0	1.02
Adipose	alternative TSS	0	0.96
Adipose	gene expression	1	1.03
Adipose	isoform ratio	0	0.97
Adipose	intron excision ratio	0	0.94
Adipose	mRNA stability	0	1.02
BLA	alternative polyA	0	1.03
BLA	alternative TSS	0	0.96
BLA	gene expression	0	1.05
BLA	isoform ratio	0	0.97
BLA	intron excision ratio	0	1
BLA	mRNA stability	0	1.08
Brain	alternative polyA	0	0.98
Brain	alternative TSS	0	0.99
Brain	gene expression	0	1.04
Brain	isoform ratio	0	0.98
Brain	intron excision ratio	0	1.02
Brain	mRNA stability	0	1.02
Eye	alternative polyA	0	0.83
Eye	alternative TSS	0	1.03
Eye	gene expression	0	1.08
Eye	isoform ratio	0	1
Eye	intron excision ratio	0	1.01
Eye	mRNA stability	0	0.89
IL	alternative polyA	0	1.06
IL	alternative TSS	0	0.95
IL	gene expression	0	1.03
IL	isoform ratio	0	0.96
IL	intron excision ratio	0	0.94
IL	mRNA stability	0	0.95
LHb	alternative polyA	0	1.02
LHb	alternative TSS	0	1.23
LHb	gene expression	0	1.02
LHb	isoform ratio	0	1.01
LHb	intron excision ratio	0	0.95
LHb	mRNA stability	0	1
Liver	alternative polyA	0	1.04
Liver	alternative TSS	0	1.01
Liver	gene expression	0	1.03
Liver	isoform ratio	0	0.99
Liver	intron excision ratio	0	1.04
Liver	mRNA stability	0	1.03
NAcc	alternative polyA	0	0.99
NAcc	alternative TSS	0	1.03
NAcc	gene expression	0	1.02
NAcc	isoform ratio	0	1
NAcc	intron excision ratio	0	1
NAcc	mRNA stability	0	1.01
OFC	alternative polyA	0	1.04
OFC	alternative TSS	0	1.27
OFC	gene expression	0	1.02
OFC	isoform ratio	0	1
OFC	intron excision ratio	0	0.93
OFC	mRNA stability	0	0.99
PL	alternative polyA	0	1
PL	alternative TSS	0	0.93
PL	gene expression	0	1.02
PL	isoform ratio	0	0.96
PL	intron excision ratio	0	1.04
PL	mRNA stability	0	1.04