Breakpoint value in progressive ratio session

Breakpoint value in the progressive ratio session after the first set of self admin sessions

Tags: Behavior · Heroin · Progressive ratio

Project: u01_peter_kalivas

1 locus · 1 gene with independent associations · 1 total associated gene

Significant Loci

# Chr Start pos End pos # assoc genes # joint models Best TWAS P Best GWAS P Cond GWAS P Joint genes
1 chr19 8453797 9852760 1 1 1.27e-07 5.03e-07 3.4e-01 LOC120098550

Pleiotropic Associations

Trait Chi2 ratio # genes+ # genes++ % genes++ Corr Corr P Genes
Heart weight 4.29 1 0 0 0 1e+00 LOC120098550
Indifference point function ln k 3.58 1 0 0 0 1e+00 LOC120098550
Indifference point function log k 3.58 1 0 0 0 1e+00 LOC120098550
Patch foraging water rate 0 sec 3.01 1 0 0 0 1e+00 LOC120098550
Patch foraging water rate 12 sec 2.66 1 0 0 0 1e+00 LOC120098550
Patch foraging water rate 6 sec 3.65 1 0 0 0 1e+00 LOC120098550
Locomotor testing rearing 4.14 1 0 0 0 1e+00 LOC120098550
Reaction time trials AUC 3.69 1 0 0 0 1e+00 LOC120098550
Social time 3.97 1 0 0 0 1e+00 LOC120098550
Cocaine response after cond. not corrected 3.55 1 0 0 0 1e+00 LOC120098550
Condit. Reinf. active-inactive response ratio 5.79 1 0 0 0 1e+00 LOC120098550
Condit. Reinf. inactive responses 4.22 1 0 0 0 1e+00 LOC120098550
Novel to familiar place preference ratio 6.16 1 0 0 0 1e+00 LOC120098550
Novelty place preference 5.58 1 0 0 0 1e+00 LOC120098550
Time in novel zone, NPP test 6.52 1 0 0 0 1e+00 LOC120098550
Diff in mean of infusions in LGA sessions 7.51 1 0 0 0 1e+00 LOC120098550
Active lever presses in extinction session 6 6.49 1 0 0 0 1e+00 LOC120098550
Sum of active levers in priming session hrs 5-6 10.85 1 0 0 0 1e+00 LOC120098550
Total heroin consumption 15.45 1 0 0 0 1e+00 LOC120098550
Se content in liver 3.28 1 0 0 0 1e+00 LOC120098550

Associations by panel

Tissue RNA modality # hits % hits/tests Avg chisq
Adipose alternative polyA 0 0 1.1
Adipose alternative TSS 0 0 1.04
Adipose gene expression 0 0 1.08
Adipose isoform ratio 0 0 1.04
Adipose intron excision ratio 0 0 1.05
Adipose mRNA stability 0 0 1.07
BLA alternative polyA 0 0 1.09
BLA alternative TSS 0 0 1.13
BLA gene expression 0 0 1.13
BLA isoform ratio 0 0 1.14
BLA intron excision ratio 0 0 1.12
BLA mRNA stability 0 0 1.11
Brain alternative polyA 0 0 1.08
Brain alternative TSS 0 0 1.11
Brain gene expression 0 0 1.13
Brain isoform ratio 0 0 1.11
Brain intron excision ratio 0 0 1.09
Brain mRNA stability 0 0 1.08
Eye alternative polyA 0 0 1.05
Eye alternative TSS 0 0 1.39
Eye gene expression 0 0 1.11
Eye isoform ratio 0 0 1.12
Eye intron excision ratio 0 0 1.14
Eye mRNA stability 0 0 1.05
IL alternative polyA 0 0 1.09
IL alternative TSS 0 0 1.21
IL gene expression 0 0 1.11
IL isoform ratio 0 0 1.05
IL intron excision ratio 0 0 1.05
IL mRNA stability 0 0 1.13
LHb alternative polyA 0 0 1.08
LHb alternative TSS 0 0 1.31
LHb gene expression 0 0 1.14
LHb isoform ratio 0 0 1.16
LHb intron excision ratio 0 0 1.1
LHb mRNA stability 0 0 1.14
Liver alternative polyA 0 0 1.02
Liver alternative TSS 0 0 1.1
Liver gene expression 1 0 1.1
Liver isoform ratio 0 0 1.07
Liver intron excision ratio 0 0 0.98
Liver mRNA stability 0 0 1.09
NAcc alternative polyA 0 0 1.12
NAcc alternative TSS 0 0 1.08
NAcc gene expression 0 0 1.14
NAcc isoform ratio 0 0 1.12
NAcc intron excision ratio 0 0 1.11
NAcc mRNA stability 0 0 1.1
OFC alternative polyA 0 0 1.09
OFC alternative TSS 0 0 1.17
OFC gene expression 0 0 1.15
OFC isoform ratio 0 0 1.13
OFC intron excision ratio 0 0 1.08
OFC mRNA stability 0 0 1.13
PL alternative polyA 0 0 1.09
PL alternative TSS 0 0 1.07
PL gene expression 0 0 1.13
PL isoform ratio 0 0 1.13
PL intron excision ratio 0 0 1.1
PL mRNA stability 0 0 1.11
pVTA alternative polyA 0 0 1.04
pVTA alternative TSS 0 0 1.11
pVTA gene expression 0 0 1.11
pVTA isoform ratio 0 0 1.14
pVTA intron excision ratio 0 0 1.1
pVTA mRNA stability 0 0 1.09
RMTg alternative polyA 0 0 1
RMTg alternative TSS 0 0 1.01
RMTg gene expression 0 0 1.07
RMTg isoform ratio 0 0 1.09
RMTg intron excision ratio 0 0 1.03
RMTg mRNA stability 0 0 1.09