Hub : Traits

Breakpoint value in progressive ratio session

Breakpoint value in the progressive ratio session after the first set of self admin sessions

Tags: Behavior · Heroin · Progressive ratio

Project: u01_peter_kalivas

1 locus · 1 gene with independent associations · 1 total associated gene

Significant Loci

#	Chr	Start pos	End pos	# assoc genes	# joint models	Best TWAS P	Best GWAS P	Cond GWAS P	Joint genes
1	chr19	8453797	9852760	1	1	1.27e-07	5.03e-07	3.4e-01	LOC120098550

Pleiotropic Associations

Trait	Chi2 ratio	# genes+	# genes++	% genes++	Corr	Corr P	Genes
Heart weight	4.29	1	0	0	0	1e+00	LOC120098550
Indifference point function ln k	3.58	1	0	0	0	1e+00	LOC120098550
Indifference point function log k	3.58	1	0	0	0	1e+00	LOC120098550
Patch foraging water rate 0 sec	3.01	1	0	0	0	1e+00	LOC120098550
Patch foraging water rate 12 sec	2.66	1	0	0	0	1e+00	LOC120098550
Patch foraging water rate 6 sec	3.65	1	0	0	0	1e+00	LOC120098550
Locomotor testing rearing	4.14	1	0	0	0	1e+00	LOC120098550
Reaction time trials AUC	3.69	1	0	0	0	1e+00	LOC120098550
Social time	3.97	1	0	0	0	1e+00	LOC120098550
Cocaine response after cond. not corrected	3.55	1	0	0	0	1e+00	LOC120098550
Condit. Reinf. active-inactive response ratio	5.79	1	0	0	0	1e+00	LOC120098550
Condit. Reinf. inactive responses	4.22	1	0	0	0	1e+00	LOC120098550
Novel to familiar place preference ratio	6.16	1	0	0	0	1e+00	LOC120098550
Novelty place preference	5.58	1	0	0	0	1e+00	LOC120098550
Time in novel zone, NPP test	6.52	1	0	0	0	1e+00	LOC120098550
Diff in mean of infusions in LGA sessions	7.51	1	0	0	0	1e+00	LOC120098550
Active lever presses in extinction session 6	6.49	1	0	0	0	1e+00	LOC120098550
Sum of active levers in priming session hrs 5-6	10.85	1	0	0	0	1e+00	LOC120098550
Total heroin consumption	15.45	1	0	0	0	1e+00	LOC120098550
Se content in liver	3.28	1	0	0	0	1e+00	LOC120098550

Associations by panel

Tissue	RNA modality	# hits	% hits/tests	Avg chisq
Adipose	alternative polyA	0	0	1.1
Adipose	alternative TSS	0	0	1.04
Adipose	gene expression	0	0	1.08
Adipose	isoform ratio	0	0	1.04
Adipose	intron excision ratio	0	0	1.05
Adipose	mRNA stability	0	0	1.07
BLA	alternative polyA	0	0	1.09
BLA	alternative TSS	0	0	1.13
BLA	gene expression	0	0	1.13
BLA	isoform ratio	0	0	1.14
BLA	intron excision ratio	0	0	1.12
BLA	mRNA stability	0	0	1.11
Brain	alternative polyA	0	0	1.08
Brain	alternative TSS	0	0	1.11
Brain	gene expression	0	0	1.13
Brain	isoform ratio	0	0	1.11
Brain	intron excision ratio	0	0	1.09
Brain	mRNA stability	0	0	1.08
Eye	alternative polyA	0	0	1.05
Eye	alternative TSS	0	0	1.39
Eye	gene expression	0	0	1.11
Eye	isoform ratio	0	0	1.12
Eye	intron excision ratio	0	0	1.14
Eye	mRNA stability	0	0	1.05
IL	alternative polyA	0	0	1.09
IL	alternative TSS	0	0	1.21
IL	gene expression	0	0	1.11
IL	isoform ratio	0	0	1.05
IL	intron excision ratio	0	0	1.05
IL	mRNA stability	0	0	1.13
LHb	alternative polyA	0	0	1.08
LHb	alternative TSS	0	0	1.31
LHb	gene expression	0	0	1.14
LHb	isoform ratio	0	0	1.16
LHb	intron excision ratio	0	0	1.1
LHb	mRNA stability	0	0	1.14
Liver	alternative polyA	0	0	1.02
Liver	alternative TSS	0	0	1.1
Liver	gene expression	1	0	1.1
Liver	isoform ratio	0	0	1.07
Liver	intron excision ratio	0	0	0.98
Liver	mRNA stability	0	0	1.09
NAcc	alternative polyA	0	0	1.12
NAcc	alternative TSS	0	0	1.08
NAcc	gene expression	0	0	1.14
NAcc	isoform ratio	0	0	1.12
NAcc	intron excision ratio	0	0	1.11
NAcc	mRNA stability	0	0	1.1
OFC	alternative polyA	0	0	1.09
OFC	alternative TSS	0	0	1.17
OFC	gene expression	0	0	1.15
OFC	isoform ratio	0	0	1.13
OFC	intron excision ratio	0	0	1.08
OFC	mRNA stability	0	0	1.13
PL	alternative polyA	0	0	1.09
PL	alternative TSS	0	0	1.07
PL	gene expression	0	0	1.13
PL	isoform ratio	0	0	1.13
PL	intron excision ratio	0	0	1.1
PL	mRNA stability	0	0	1.11
pVTA	alternative polyA	0	0	1.04
pVTA	alternative TSS	0	0	1.11
pVTA	gene expression	0	0	1.11
pVTA	isoform ratio	0	0	1.14
pVTA	intron excision ratio	0	0	1.1
pVTA	mRNA stability	0	0	1.09
RMTg	alternative polyA	0	0	1
RMTg	alternative TSS	0	0	1.01
RMTg	gene expression	0	0	1.07
RMTg	isoform ratio	0	0	1.09
RMTg	intron excision ratio	0	0	1.03
RMTg	mRNA stability	0	0	1.09