Hub : Traits

Progressive ratio test 1 breakpoint

Tags: Behavior · Motivation · Progressive ratio

Project: p50_paul_meyer_2020

2 loci · 2 genes with independent associations · 2 total associated genes

Significant Loci

#	Chr	Start pos	End pos	# assoc genes	# joint models	Best TWAS P	Best GWAS P	Cond GWAS P	Joint genes
1	chr4	95890735	97085238	1	1	3.33e-08	3.37e-01	3.92e-32	Serbp1
2	chr7	14449451	15768722	1	1	5.84e-10	5.12e-01	1.00e+00	LOC102551633

Pleiotropic Associations

Trait	Chi2 ratio	# genes+	# genes++	% genes++	Corr	Corr P	Genes
BMI without tail	5.19	1	0	0	0	1e+00	Serbp1
Right kidney weight	8.78	1	0	0	0	1e+00	Serbp1
Tail length	2.86	1	0	0	0	1e+00	Serbp1
Length with tail	3.13	1	0	0	0	1e+00	Serbp1
Liver weight, left	7.79	1	0	0	0	1e+00	Serbp1
Retroperitoneal fat weight	3.15	1	0	0	0	1e+00	Serbp1
Intraocular pressure	5.48	1	0	0	0	1e+00	Serbp1
Patch foraging indifference point 0 sec	7.74	1	0	0	0	1e+00	LOC102551633
Patch foraging indifference point AUC	12.17	1	0	0	0	1e+00	Serbp1
Patch foraging total patch changes 0 sec	7.23	1	0	0	0	1e+00	LOC102551633
Patch foraging total patch changes 18 sec	10.94	1	0	0	0	1e+00	Serbp1
Patch foraging total patch changes 6 sec	6.58	2	0	0	0	1e+00	LOC102551633 Serbp1
Patch foraging water rate 0 sec	6.51	1	0	0	0	1e+00	Serbp1
Patch foraging water rate 12 sec	4.1	1	0	0	0	1e+00	Serbp1
Patch foraging water rate 18 sec	5.55	1	0	0	0	1e+00	Serbp1
Locomotor activity	3.78	2	0	0	0	1e+00	LOC102551633 Serbp1
Locomotor testing distance	3.92	1	0	0	0	1e+00	LOC102551633
Light reinforcement 1	8.51	1	0	0	0	1e+00	Serbp1
Light reinforcement 2	7.05	1	0	0	0	1e+00	Serbp1
Reaction time mean AUC	4.32	1	0	0	0	1e+00	Serbp1
Reaction time omissions	4.8	1	0	0	0	1e+00	Serbp1
Reaction time premature initiations	6.63	1	0	0	0	1e+00	Serbp1
Social time	4.57	1	0	0	0	1e+00	Serbp1
Conditioned reinforcement - actives	6.27	1	0	0	0	1e+00	LOC102551633
Conditioned reinforcement - inactives	5.74	1	0	0	0	1e+00	LOC102551633
Conditioned locomotion	31.08	2	1	50	0	1e+00	LOC102551633 Serbp1
Intermittent access intake escalation 2	13.41	1	0	0	0	1e+00	LOC102551633
Intermitt. access day 15 inactive lever presses	5.48	1	0	0	0	1e+00	Serbp1
Intermitt. access escalation Index	57.91	1	1	50	0	1e+00	LOC102551633
Intermittent access day 1 total infusions	15.46	2	0	0	0	1e+00	LOC102551633 Serbp1
Intermittent access day 15 total infusions	8.69	2	0	0	0	1e+00	LOC102551633 Serbp1
Intermittent access terminal intake (last 3 days)	47.4	2	2	100	0	1e+00	LOC102551633 Serbp1
Intermittent access total infusions	11.4	2	0	0	0	1e+00	LOC102551633 Serbp1
Intermittent access day 15 total locomotion	32.88	1	1	50	0	1e+00	LOC102551633
Intermittent access total locomotion	12.95	1	0	0	0	1e+00	LOC102551633
Intermittent access standard deviation	5.46	1	0	0	0	1e+00	Serbp1
Lifetime Intake	13.1	2	0	0	0	1e+00	LOC102551633 Serbp1
Incentive Sensitization - Responses	8.44	1	0	0	0	1e+00	LOC102551633
Incentive Sensitization - Breakpoint	6.89	1	0	0	0	1e+00	LOC102551633
Progressive ratio test 1 active lever presses	19.84	2	0	0	0	1e+00	LOC102551633 Serbp1
Progressive ratio test 1 inactive lever presses	20.71	2	1	50	0	1e+00	LOC102551633 Serbp1
Progressive ratio test 2 active lever presses	10.25	1	0	0	0	1e+00	Serbp1
Progressive ratio test 2 breakpoint	10.07	1	0	0	0	1e+00	Serbp1
Progressive ratio test 2 inactive lever presses	14.53	2	0	0	0	1e+00	LOC102551633 Serbp1
Total sessions with >9 infusions	40.15	1	1	50	0	1e+00	Serbp1
Short access day 1 total inactive lever presses	29.19	2	1	50	0	1e+00	LOC102551633 Serbp1
Short access day 10 total inactive lever presses	26.2	2	1	50	0	1e+00	LOC102551633 Serbp1
Short access day 1 total infusions	45.2	2	1	50	0	1e+00	LOC102551633 Serbp1
Short access day 10 total infusions	30.94	1	1	50	0	1e+00	LOC102551633
Short access total infusions	26.87	2	1	50	0	1e+00	LOC102551633 Serbp1
Short access day 1 locomotion	15.32	2	0	0	0	1e+00	LOC102551633 Serbp1
Compulsive drug intake	12.43	1	0	0	0	1e+00	Serbp1
One hour access (shock baseline)	6.09	1	0	0	0	1e+00	LOC102551633
Number of responses in last shaping day	11.97	2	0	0	0	1e+00	LOC102551633 Serbp1
Locomotion distance, session 3	4.8	1	0	0	0	1e+00	LOC102551633
Locomotion velocity, session 7	6.12	1	0	0	0	1e+00	Serbp1
Degree of sensitization distance	11.08	1	0	0	0	1e+00	LOC102551633
Pavlov. Cond. lever latency	5.45	1	0	0	0	1e+00	LOC102551633
Pavlov. Cond. latency score	4.54	1	0	0	0	1e+00	LOC102551633
Pavlov. Cond. lever contacts	5.74	1	0	0	0	1e+00	LOC102551633
Bone: final force	3.95	1	0	0	0	1e+00	LOC102551633
Bone: final moment	3.68	1	0	0	0	1e+00	LOC102551633
Bone: maximum force	3.84	1	0	0	0	1e+00	LOC102551633
Bone: maximum moment	3.51	1	0	0	0	1e+00	LOC102551633
Bone: stiffness	4.72	1	0	0	0	1e+00	LOC102551633
Distance traveled before self-admin	53.87	1	1	50	0	1e+00	LOC102551633
Distance traveled after self-admin	46.63	1	1	50	0	1e+00	LOC102551633
Delta time in closed arm before/after self-admin	10.9	1	0	0	0	1e+00	Serbp1
Delta time in open arm before/after self-admin	23.57	1	0	0	0	1e+00	Serbp1
Diff in mean of infusions in LGA sessions	18.85	1	0	0	0	1e+00	Serbp1
Extinction: sum of active levers before priming	26.18	1	0	0	0	1e+00	LOC102551633
Active lever presses in extinction session 6	29.08	1	1	50	0	1e+00	Serbp1
Delta ambulatory time before/after self-admin	13.21	1	0	0	0	1e+00	LOC102551633
Time in closed arm before self-admin	13.02	1	0	0	0	1e+00	Serbp1
Time in closed arm after self-admin	7.59	2	0	0	0	1e+00	LOC102551633 Serbp1
Time in open arm before self-admin	28.75	1	1	50	0	1e+00	LOC102551633
Time in open arm after self-admin	5.82	1	0	0	0	1e+00	LOC102551633
Sum of active levers in priming session hrs 5-6	13.86	2	0	0	0	1e+00	LOC102551633 Serbp1
Time to tail flick, vehicle, before self-admin	34.21	2	1	50	0	1e+00	LOC102551633 Serbp1
Time to tail flick, vehicle, after self-admin	51.34	2	2	100	0	1e+00	LOC102551633 Serbp1
Time to tail flick, test, before self-admin	5.82	1	0	0	0	1e+00	Serbp1
Delta time to tail flick, vehicle, before/after SA	66.24	2	1	50	0	1e+00	LOC102551633 Serbp1
Ambulatory time before self-admin	11.05	1	0	0	0	1e+00	LOC102551633
Ambulatory time after self-admin	17.31	2	0	0	0	1e+00	LOC102551633 Serbp1
Total heroin consumption	20.76	2	1	50	0	1e+00	LOC102551633 Serbp1
Change in fecal boli incidents, locomotor task	13.85	1	0	0	0	1e+00	Serbp1
Rest time, locomotor task time 1	16.73	1	0	0	0	1e+00	Serbp1
Vertical activity count, locomotor time 1	12.05	1	0	0	0	1e+00	Serbp1
Vertical activity count, locomotor time 2	6.77	1	0	0	0	1e+00	Serbp1
Seeking ratio, delayed vs. immediate footshock	7.65	2	0	0	0	1e+00	LOC102551633 Serbp1
Locomotion in novel chamber post-restriction	18.24	1	0	0	0	1e+00	Serbp1
Co content in liver	12.69	1	0	0	0	1e+00	LOC102551633
Fe content in liver	7.51	1	0	0	0	1e+00	LOC102551633
K content in liver	11.66	1	0	0	0	1e+00	LOC102551633
Na content in liver	44.6	1	1	50	0	1e+00	LOC102551633
Rb content in liver	16.75	1	0	0	0	1e+00	LOC102551633
Se content in liver	12.37	1	0	0	0	1e+00	LOC102551633

Associations by panel

Tissue	RNA modality	# hits	% hits/tests	Avg chisq
Adipose	alternative polyA	0	0	1.03
Adipose	alternative TSS	0	0	1.01
Adipose	gene expression	0	0	1.04
Adipose	isoform ratio	0	0	1.04
Adipose	intron excision ratio	0	0	1.01
Adipose	mRNA stability	0	0	1.03
BLA	alternative polyA	0	0	1.07
BLA	alternative TSS	0	0	1
BLA	gene expression	0	0	1.05
BLA	isoform ratio	0	0	1
BLA	intron excision ratio	0	0	1.01
BLA	mRNA stability	0	0	1.05
Brain	alternative polyA	0	0	1.06
Brain	alternative TSS	0	0	1.01
Brain	gene expression	0	0	1.04
Brain	isoform ratio	0	0	1.05
Brain	intron excision ratio	0	0	1.02
Brain	mRNA stability	0	0	1.06
Eye	alternative polyA	0	0	0.96
Eye	alternative TSS	0	0	0.96
Eye	gene expression	0	0	1.06
Eye	isoform ratio	0	0	1.01
Eye	intron excision ratio	0	0	0.97
Eye	mRNA stability	0	0	1.05
IL	alternative polyA	0	0	1.06
IL	alternative TSS	0	0	1.03
IL	gene expression	0	0	1.05
IL	isoform ratio	0	0	1.06
IL	intron excision ratio	0	0	1.07
IL	mRNA stability	0	0	1.13
LHb	alternative polyA	0	0	1.05
LHb	alternative TSS	0	0	1.09
LHb	gene expression	0	0	1.05
LHb	isoform ratio	0	0	1.06
LHb	intron excision ratio	0	0	0.98
LHb	mRNA stability	0	0	1.08
Liver	alternative polyA	0	0	1.06
Liver	alternative TSS	0	0	1.15
Liver	gene expression	0	0	1.04
Liver	isoform ratio	1	0	1.1
Liver	intron excision ratio	0	0	1.07
Liver	mRNA stability	0	0	1.04
NAcc	alternative polyA	0	0	1.09
NAcc	alternative TSS	0	0	1.03
NAcc	gene expression	0	0	1.05
NAcc	isoform ratio	0	0	1.04
NAcc	intron excision ratio	0	0	1.03
NAcc	mRNA stability	0	0	1.09
OFC	alternative polyA	0	0	1.08
OFC	alternative TSS	0	0	1.11
OFC	gene expression	0	0	1.03
OFC	isoform ratio	0	0	1.02
OFC	intron excision ratio	0	0	0.95
OFC	mRNA stability	0	0	1.09
PL	alternative polyA	0	0	1.07
PL	alternative TSS	0	0	1.06
PL	gene expression	0	0	1.05
PL	isoform ratio	0	0	1.08
PL	intron excision ratio	0	0	1.05
PL	mRNA stability	0	0	1.11
pVTA	alternative polyA	0	0	1.16
pVTA	alternative TSS	0	0	1.03
pVTA	gene expression	0	0	1.08
pVTA	isoform ratio	0	0	1.07
pVTA	intron excision ratio	0	0	0.97
pVTA	mRNA stability	0	0	1.15
RMTg	alternative polyA	1	0.2	0.97
RMTg	alternative TSS	0	0	1.04
RMTg	gene expression	0	0	1.02
RMTg	isoform ratio	0	0	1.07
RMTg	intron excision ratio	0	0	1
RMTg	mRNA stability	0	0	1.07