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Delay disc. indifference point, 8s delay

Abnormal impulse behavior control/Impulsivity assay, delay discounting using an adjusting amount procedure: subject’s calculated indifference point for all exposures/repetitions of 8s delay sessions in 11-16 week old NIH heterogeneous stock rats for males and females (MEDPC V equipment, where immediate lever with 0s delay provides choice dependent adjusting amounts starting at 75 microliter of sucrose solution and delayed lever provides 150 microliter of sucrose solution) [microliter].

Tags: Behavior · Impulsivity · Delay discounting

Project: u01_suzanne_mitchell

1 significantly associated model · 1 unique gene

Significant Loci

# chr p0 p1 # assoc genes # joint models best TWAS P best SNP P cond SNP P % var exp joint genes
1 10 62271668 63667097 1 1 6.3e-18 0.15 3.1e-25 -5052 Eral1

p0: physical position of the start of the locus. p1: physical position of the end of the locus. # joint models: number of models selected by step-wise conditional analysis.

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Heart weight 3.6 1 0 0 0 1 Eral1
Left kidney weight 1.5 1 0 0 0 1 Eral1
Food consumed during 24 hour testing period 14.7 1 0 0 0 1 Eral1
Times rat made contact with spout 19.6 1 0 0 0 1 Eral1
Mean time between licks in bursts 5.6 1 0 0 0 1 Eral1
Mean num. licks in bursts 16.6 1 0 0 0 1 Eral1
Std. dev. time between licks in bursts 13.9 1 0 0 0 1 Eral1
Intermittent access intake escalation 2 6.5 1 0 0 0 1 Eral1
Intermitt. access day 1 inactive lever presses 5.8 1 0 0 0 1 Eral1
Intermitt. access day 15 inactive lever presses 19.8 1 0 0 0 1 Eral1
Intermittent access total locomotion 7.3 1 0 0 0 1 Eral1
Short access day 10 total inactive lever presses 4.2 1 0 0 0 1 Eral1
Short access day 1 total infusions 28.5 1 1 100 0 1 Eral1
Short access total infusions 17.6 1 0 0 0 1 Eral1
Short access day 1 locomotion 23.2 1 0 0 0 1 Eral1
Short access total locomotion 23.8 1 0 0 0 1 Eral1
Breakpoint value in progressive ratio session 7.3 1 0 0 0 1 Eral1
Distance traveled before self-admin 58.4 1 1 100 0 1 Eral1
Distance traveled after self-admin 7.5 1 0 0 0 1 Eral1
Delta time in open arm before/after self-admin 8.0 1 0 0 0 1 Eral1
Extinction: sum of active levers before priming 8.2 1 0 0 0 1 Eral1
Active lever presses in extinction session 6 20.2 1 0 0 0 1 Eral1
Delta distance traveled before/after self-admin 8.5 1 0 0 0 1 Eral1
Delta ambulatory time before/after self-admin 37.5 1 1 100 0 1 Eral1
Time in open arm after self-admin 10.5 1 0 0 0 1 Eral1
Time to tail flick, vehicle, before self-admin 10.1 1 0 0 0 1 Eral1
Time to tail flick, vehicle, after self-admin 4.9 1 0 0 0 1 Eral1
Ambulatory time before self-admin 49.1 1 1 100 0 1 Eral1
Ambulatory time after self-admin 6.6 1 0 0 0 1 Eral1
Total heroin consumption 3.3 1 0 0 0 1 Eral1
Area under the delay curve 45.5 1 1 100 0 1 Eral1
Delay disc. indifference point, 16s delay 63.9 1 1 100 0 1 Eral1
Delay disc. indifference point, 24s delay 9.5 1 0 0 0 1 Eral1
Delay disc. indifference point, 4s delay 6.5 1 0 0 0 1 Eral1
Delay discount exponential model param 36.3 1 1 100 0 1 Eral1
Delay discount hyperbolic model param 29.7 1 1 100 0 1 Eral1
Rest time, locomotor task time 1 15.2 1 0 0 0 1 Eral1
Distance moved, locomotor task time 1 3.7 1 0 0 0 1 Eral1
Time >=10cm from walls, locomotor time 2 39.8 1 1 100 0 1 Eral1
Rest time, locomotor task time 2 5.6 1 0 0 0 1 Eral1
Distance moved, locomotor task time 2 13.4 1 0 0 0 1 Eral1
Vertical activity count, locomotor time 2 8.7 1 0 0 0 1 Eral1
Weight adjusted by age 3.4 1 0 0 0 1 Eral1
Locomotion in novel chamber post-restriction 13.5 1 0 0 0 1 Eral1
Progressive ratio 27.9 1 1 100 0 1 Eral1
Food seeking constrained by brief footshock 14.0 1 0 0 0 1 Eral1
Seeking ratio, punishment vs. effort 10.2 1 0 0 0 1 Eral1
Run reversals in cocaine runway, males 48.1 1 1 100 0 1 Eral1
Latency to leave start box in cocaine runway 12.6 1 0 0 0 1 Eral1
Latency to leave start box in cocaine runway, M 38.5 1 1 100 0 1 Eral1

chisq ratio: Average Chi2 statistic for the selected genes in the secondary trait, divided by the average statistic for all genes in the secondary trait. # genes+: Shared significant genes at Bonferroni correction. # genes++: Shared significant genes at transcriptome-wide significance. % genes++: Number of [++] genes as a percentage of primary trait’s total joint genes. corr: Correlation of effect sizes across the [+] genes.

Associations by panel

tissue modality # hits % hits/tests avg chisq
Adipose alternative polyA 0 0.000 1.06
Adipose alternative TSS 0 0.000 1.04
Adipose gene expression 1 0.012 1.05
Adipose isoform ratio 0 0.000 1.00
Adipose intron excision ratio 0 0.000 1.06
Adipose mRNA stability 0 0.000 1.00
BLA alternative polyA 0 0.000 1.15
BLA alternative TSS 0 0.000 0.94
BLA gene expression 0 0.000 1.08
BLA isoform ratio 0 0.000 0.98
BLA intron excision ratio 0 0.000 1.00
BLA mRNA stability 0 0.000 1.06
Brain alternative polyA 0 0.000 1.09
Brain alternative TSS 0 0.000 1.00
Brain gene expression 0 0.000 1.05
Brain isoform ratio 0 0.000 1.01
Brain intron excision ratio 0 0.000 1.02
Brain mRNA stability 0 0.000 1.00
Eye alternative polyA 0 0.000 0.92
Eye alternative TSS 0 0.000 0.91
Eye gene expression 0 0.000 1.01
Eye isoform ratio 0 0.000 1.20
Eye intron excision ratio 0 0.000 0.98
Eye mRNA stability 0 0.000 1.04
IL alternative polyA 0 0.000 1.12
IL alternative TSS 0 0.000 0.98
IL gene expression 0 0.000 1.04
IL isoform ratio 0 0.000 0.93
IL intron excision ratio 0 0.000 0.93
IL mRNA stability 0 0.000 0.98
LHb alternative polyA 0 0.000 1.08
LHb alternative TSS 0 0.000 1.01
LHb gene expression 0 0.000 1.06
LHb isoform ratio 0 0.000 1.04
LHb intron excision ratio 0 0.000 0.95
LHb mRNA stability 0 0.000 1.03
Liver alternative polyA 0 0.000 1.15
Liver alternative TSS 0 0.000 1.00
Liver gene expression 0 0.000 1.06
Liver isoform ratio 0 0.000 1.07
Liver intron excision ratio 0 0.000 1.09
Liver mRNA stability 0 0.000 1.01
NAcc alternative polyA 0 0.000 1.11
NAcc alternative TSS 0 0.000 1.02
NAcc gene expression 0 0.000 1.06
NAcc isoform ratio 0 0.000 0.94
NAcc intron excision ratio 0 0.000 1.02
NAcc mRNA stability 0 0.000 1.06
OFC alternative polyA 0 0.000 1.17
OFC alternative TSS 0 0.000 1.12
OFC gene expression 0 0.000 1.05
OFC isoform ratio 0 0.000 1.01
OFC intron excision ratio 0 0.000 0.94
OFC mRNA stability 0 0.000 0.94
PL alternative polyA 0 0.000 1.10
PL alternative TSS 0 0.000 0.95
PL gene expression 0 0.000 1.07
PL isoform ratio 0 0.000 0.95
PL intron excision ratio 0 0.000 1.02
PL mRNA stability 0 0.000 1.03

avg chisq: Average Chi2 (squared Z-score) across all models in this panel for this trait.