Rest time, locomotor task time 2

Inactive time during the session, where inactivity was classified as no change in beam breaks for a period greater than or equal to 1s in time2

Tags: Behavior · Locomotion

Project: u01_suzanne_mitchell

2 loci · 2 genes with independent associations · 2 total associated genes

Significant Loci

# Chr Start pos End pos # assoc genes # joint models Best TWAS P Best GWAS P Cond GWAS P Joint genes
1 chr8 108585012 109845634 1 1 6.84e-08 4.13e-01 1e+00 Klhdc8b
2 chr9 75969545 77365260 1 1 6.85e-13 2.66e-01 1e+00 Zfand2b

Pleiotropic Associations

Trait Chi2 ratio # genes+ # genes++ % genes++ Corr Corr P Genes
BMI with tail 13.63 2 2 100 0 1e+00 Klhdc8b Zfand2b
BMI without tail 40.36 2 2 100 0 1e+00 Klhdc8b Zfand2b
Body weight 20.7 1 1 50 0 1e+00 Klhdc8b
Epididymis fat weight 111.28 1 1 50 0 1e+00 Zfand2b
Heart weight 44.47 2 1 50 0 1e+00 Klhdc8b Zfand2b
Left kidney weight 27.6 2 2 100 0 1e+00 Klhdc8b Zfand2b
Right kidney weight 32.19 2 2 100 0 1e+00 Klhdc8b Zfand2b
Tail length 66.87 2 1 50 0 1e+00 Klhdc8b Zfand2b
Length with tail 7.02 2 1 50 0 1e+00 Klhdc8b Zfand2b
Length without tail 39.91 2 1 50 0 1e+00 Klhdc8b Zfand2b
Liver weight, left 13.45 1 0 0 0 1e+00 Klhdc8b
Liver weight, right 10.4 2 1 50 0 1e+00 Klhdc8b Zfand2b
Parametrial fat weight 9.99 1 0 0 0 1e+00 Zfand2b
Retroperitoneal fat weight 6.88 2 0 0 0 1e+00 Klhdc8b Zfand2b
Intraocular pressure 51.69 1 1 50 0 1e+00 Zfand2b
Soleus weight 8.84 1 0 0 0 1e+00 Klhdc8b
Tibialis anterior weight 1.65 1 0 0 0 1e+00 Zfand2b
Tibia length 10.96 1 1 50 0 1e+00 Klhdc8b
Number of licking bursts 28.51 2 2 100 0 1e+00 Klhdc8b Zfand2b
Food consumed during 24 hour testing period 12.4 2 0 0 0 1e+00 Klhdc8b Zfand2b
Times rat made contact with spout 7.29 2 0 0 0 1e+00 Klhdc8b Zfand2b
Mean time between licks in bursts 7.18 2 0 0 0 1e+00 Klhdc8b Zfand2b
Mean num. licks in bursts 14.92 2 0 0 0 1e+00 Klhdc8b Zfand2b
Std. dev. time between licks in bursts 12.12 1 0 0 0 1e+00 Zfand2b
Water consumed over 24 hours 21.34 2 1 50 0 1e+00 Klhdc8b Zfand2b
Patch foraging indifference point 0 sec 9.99 2 0 0 0 1e+00 Klhdc8b Zfand2b
Patch foraging indifference point AUC 14.47 2 1 50 0 1e+00 Klhdc8b Zfand2b
Indifference point function ln k 45.4 2 2 100 0 1e+00 Klhdc8b Zfand2b
Indifference point function log k 45.4 2 2 100 0 1e+00 Klhdc8b Zfand2b
Patch foraging total patch changes 0 sec 16.18 2 1 50 0 1e+00 Klhdc8b Zfand2b
Patch foraging total patch changes 12 sec 4.29 1 0 0 0 1e+00 Zfand2b
Patch foraging total patch changes 18 sec 26.8 2 1 50 0 1e+00 Klhdc8b Zfand2b
Patch foraging total patch changes 24 sec 42.08 2 1 50 0 1e+00 Klhdc8b Zfand2b
Patch foraging total patch changes 6 sec 24.67 1 1 50 0 1e+00 Zfand2b
Patch foraging time to switch 0 sec 20.1 2 1 50 0 1e+00 Klhdc8b Zfand2b
Patch foraging water rate 0 sec 39.47 1 1 50 0 1e+00 Zfand2b
Patch foraging water rate 12 sec 69.49 1 1 50 0 1e+00 Zfand2b
Patch foraging water rate 18 sec 9.71 1 0 0 0 1e+00 Zfand2b
Patch foraging water rate 24 sec 12.61 1 0 0 0 1e+00 Zfand2b
Patch foraging water rate 6 sec 35.43 1 1 50 0 1e+00 Zfand2b
Locomotor activity 35.08 2 1 50 0 1e+00 Klhdc8b Zfand2b
Locomotor testing distance 55.86 2 2 100 0 1e+00 Klhdc8b Zfand2b
Locomotor testing rearing 51.45 2 1 50 0 1e+00 Klhdc8b Zfand2b
Light reinforcement 1 19.25 1 1 50 0 1e+00 Zfand2b
Light reinforcement 2 6.84 2 0 0 0 1e+00 Klhdc8b Zfand2b
Reaction time number correct 66.72 2 2 100 0 1e+00 Klhdc8b Zfand2b
Reaction time mean minus median 179.03 1 1 50 0 1e+00 Zfand2b
Reaction time mean minus median AUC 232.47 1 1 50 0 1e+00 Zfand2b
Reaction time num false alarms 5.73 2 0 0 0 1e+00 Klhdc8b Zfand2b
Reaction time num false alarms AUC 17.01 2 1 50 0 1e+00 Klhdc8b Zfand2b
Reaction time trials correct on left 66.72 2 2 100 0 1e+00 Klhdc8b Zfand2b
Reaction time trials on left 63.1 2 2 100 0 1e+00 Klhdc8b Zfand2b
Reaction time mean 36.11 1 1 50 0 1e+00 Zfand2b
Reaction time mean AUC 21.6 2 1 50 0 1e+00 Klhdc8b Zfand2b
Median of all reaction times 14.09 2 0 0 0 1e+00 Klhdc8b Zfand2b
Reaction time omissions 35.15 2 2 100 0 1e+00 Klhdc8b Zfand2b
Reaction time false alarm rate 12.08 2 1 50 0 1e+00 Klhdc8b Zfand2b
Reaction time premature initiations 23.4 2 1 50 0 1e+00 Klhdc8b Zfand2b
Std. dev. reaction times 38.37 2 1 50 0 1e+00 Klhdc8b Zfand2b
Reaction time trials completed 63.1 2 2 100 0 1e+00 Klhdc8b Zfand2b
Reaction time trials AUC 64.7 2 2 100 0 1e+00 Klhdc8b Zfand2b
Social response proportion 6.01 1 0 0 0 1e+00 Zfand2b
Conditioned locomotion 28.4 1 1 50 0 1e+00 Klhdc8b
Cocaine response after cond. corrected 12.71 1 0 0 0 1e+00 Zfand2b
Cocaine response after cond. not corrected 13.66 2 0 0 0 1e+00 Klhdc8b Zfand2b
Cocaine response before conditioning 38.66 1 1 50 0 1e+00 Klhdc8b
Saline control response 6.32 2 0 0 0 1e+00 Klhdc8b Zfand2b
Condit. Reinf. lever presses 5.55 1 0 0 0 1e+00 Zfand2b
Pavlov. Cond. magazine entry latency 5.33 1 0 0 0 1e+00 Klhdc8b
Pavlov. Cond. magazine entry number 30 1 1 50 0 1e+00 Klhdc8b
Pavlov. Cond. intertrial magazine entries 7.56 1 0 0 0 1e+00 Klhdc8b
Pavlov. Cond. response bias 5.18 1 0 0 0 1e+00 Klhdc8b
Conditioned reinforcement - actives 152.54 1 1 50 0 1e+00 Zfand2b
Conditioned reinforcement - inactives 76.2 2 1 50 0 1e+00 Klhdc8b Zfand2b
Conditioned locomotion 9.06 2 0 0 0 1e+00 Klhdc8b Zfand2b
Intermittent access intake day 1-15 change 156.77 1 1 50 0 1e+00 Zfand2b
Intermittent access intake escalation 117.41 1 1 50 0 1e+00 Zfand2b
Intermitt. access day 1 inactive lever presses 91.66 2 1 50 0 1e+00 Klhdc8b Zfand2b
Intermitt. access day 15 inactive lever presses 162.52 2 2 100 0 1e+00 Klhdc8b Zfand2b
Intermittent access day 1 total infusions 39.22 2 1 50 0 1e+00 Klhdc8b Zfand2b
Intermittent access day 15 total infusions 24.8 2 1 50 0 1e+00 Klhdc8b Zfand2b
Intermittent access terminal intake (last 3 days) 24.92 2 1 50 0 1e+00 Klhdc8b Zfand2b
Intermittent access total infusions 15.45 1 0 0 0 1e+00 Klhdc8b
Intermittent access day 1 locomotion 18.98 2 1 50 0 1e+00 Klhdc8b Zfand2b
Intermittent access day 15 total locomotion 93.08 1 1 50 0 1e+00 Zfand2b
Intermittent access total locomotion 12.43 1 0 0 0 1e+00 Zfand2b
Intermittent access standard deviation 229.66 2 1 50 0 1e+00 Klhdc8b Zfand2b
Cocaine induced anxiety 69.5 2 1 50 0 1e+00 Klhdc8b Zfand2b
Baseline Anxiety 393.92 1 1 50 0 1e+00 Zfand2b
Lifetime Intake 9.49 1 0 0 0 1e+00 Klhdc8b
Incentive Sensitization - Responses 309.83 1 1 50 0 1e+00 Zfand2b
Incentive Sensitization - Breakpoint 300.45 1 1 50 0 1e+00 Zfand2b
Progressive ratio test 1 active lever presses 26.41 1 1 50 0 1e+00 Zfand2b
Progressive ratio test 1 breakpoint 19.19 1 0 0 0 1e+00 Zfand2b
Progressive ratio test 1 inactive lever presses 16.55 1 0 0 0 1e+00 Klhdc8b
Progressive ratio test 2 active lever presses 57.01 2 1 50 0 1e+00 Klhdc8b Zfand2b
Progressive ratio test 2 breakpoint 106.65 1 1 50 0 1e+00 Zfand2b
Progressive ratio test 2 inactive lever presses 37.15 2 1 50 0 1e+00 Klhdc8b Zfand2b
Total sessions with >9 infusions 16 1 0 0 0 1e+00 Klhdc8b
Short access day 1 total inactive lever presses 17.49 2 0 0 0 1e+00 Klhdc8b Zfand2b
Short access day 10 total inactive lever presses 72.35 2 2 100 0 1e+00 Klhdc8b Zfand2b
Short access day 10 total infusions 13.17 1 0 0 0 1e+00 Klhdc8b
Short access total infusions 5.11 1 0 0 0 1e+00 Klhdc8b
Short access day 1 locomotion 70.49 2 1 50 0 1e+00 Klhdc8b Zfand2b
Short access day 10 total locomotion 432.47 1 1 50 0 1e+00 Zfand2b
Short access total locomotion 209.96 1 1 50 0 1e+00 Zfand2b
Compulsive drug intake 68.39 1 1 50 0 1e+00 Zfand2b
One hour access (0.3 mA shock) 18.01 2 0 0 0 1e+00 Klhdc8b Zfand2b
One hour access (shock baseline) 8.36 1 0 0 0 1e+00 Klhdc8b
Number of responses in last shaping day 67.75 1 1 50 0 1e+00 Zfand2b
Locomotion distance, session 1 23.98 1 1 50 0 1e+00 Klhdc8b
Locomotion velocity, session 2 10 1 0 0 0 1e+00 Klhdc8b
Locomotion distance, session 2 18.8 2 1 50 0 1e+00 Klhdc8b Zfand2b
Locomotion velocity, session 3 17.14 1 0 0 0 1e+00 Klhdc8b
Locomotion distance, session 3 14.51 1 0 0 0 1e+00 Klhdc8b
Stereotopy head waving duration, day 3 6.96 1 0 0 0 1e+00 Klhdc8b
Locomotion velocity, session 8 9.36 1 0 0 0 1e+00 Klhdc8b
Locomotion distance, session 8 52.78 1 1 50 0 1e+00 Klhdc8b
Degree of sensitization distance 24.75 1 0 0 0 1e+00 Klhdc8b
Condit. Reinf. active minus inactive responses 35.59 1 1 50 0 1e+00 Klhdc8b
Condit. Reinf. active-inactive response ratio 25.6 1 1 50 0 1e+00 Klhdc8b
Condit. Reinf. active responses 18.23 1 0 0 0 1e+00 Klhdc8b
Incentive salience index mean 26.23 1 1 50 0 1e+00 Klhdc8b
Condit. Reinf. lever presses 10.81 1 0 0 0 1e+00 Klhdc8b
Time in familiar zone, hab. session 1 63.49 1 1 50 0 1e+00 Klhdc8b
Time in novel zone, hab. session 1 13.1 1 0 0 0 1e+00 Klhdc8b
Total zone transitions, hab. session 1 37.38 1 1 50 0 1e+00 Klhdc8b
Total locomotion distance, hab. session 1 10.76 1 0 0 0 1e+00 Klhdc8b
Locomotion velocity, hab. session 1 10.22 1 0 0 0 1e+00 Klhdc8b
Time in familiar zone, hab. session 2 27.1 1 1 50 0 1e+00 Klhdc8b
Time in novel zone, hab. session 2 10.13 1 0 0 0 1e+00 Klhdc8b
Total zone transitions, hab. session 2 69.58 1 1 50 0 1e+00 Klhdc8b
Total locomotion distance, hab. session 2 19.2 1 0 0 0 1e+00 Klhdc8b
Locomotion velocity, hab. session 2 21.15 1 1 50 0 1e+00 Klhdc8b
Novel to familiar place preference ratio 22.33 1 0 0 0 1e+00 Klhdc8b
Novelty place preference 20.99 1 0 0 0 1e+00 Klhdc8b
Time in novel zone, NPP test 17.06 1 0 0 0 1e+00 Klhdc8b
Total zone transitions, NPP test 106.24 1 1 50 0 1e+00 Klhdc8b
Total locomotion distance, NPP test 47.64 1 1 50 0 1e+00 Klhdc8b
Locomotion velocity, NPP test 51.12 1 1 50 0 1e+00 Klhdc8b
Pavlov. Cond. change in total contacts 69.48 1 1 50 0 1e+00 Klhdc8b
Pavlov. Cond. index score 14.07 1 0 0 0 1e+00 Klhdc8b
Pavlov. Cond. latency score 8.82 1 0 0 0 1e+00 Klhdc8b
Pavlov. Cond. lever contacts 4.86 1 0 0 0 1e+00 Klhdc8b
Pavlov. Cond. magazine entry number 12.23 1 0 0 0 1e+00 Klhdc8b
Pavlov. Cond. lever-magazine prob. diff. 14.82 1 0 0 0 1e+00 Klhdc8b
Pavlov. Cond. response bias 10.49 1 0 0 0 1e+00 Klhdc8b
Bone: cortical porosity 6.2 1 0 0 0 1e+00 Klhdc8b
Bone: elastic displacement 5.56 1 0 0 0 1e+00 Zfand2b
Bone: endosteal estimation 4 1 0 0 0 1e+00 Klhdc8b
Bone: final force 4.4 1 0 0 0 1e+00 Klhdc8b
Bone: marrow area 3.15 1 0 0 0 1e+00 Klhdc8b
Bone: maximum diameter 3.26 1 0 0 0 1e+00 Klhdc8b
Bone: maximum force 7.19 1 0 0 0 1e+00 Klhdc8b
Bone: maximum moment 3.52 1 0 0 0 1e+00 Klhdc8b
Bone: periosteal estimation 3.04 1 0 0 0 1e+00 Klhdc8b
Bone: stiffness 13.41 1 0 0 0 1e+00 Klhdc8b
Distance traveled before self-admin 5.58 1 0 0 0 1e+00 Zfand2b
Distance traveled after self-admin 8.9 1 0 0 0 1e+00 Zfand2b
Delta time in closed arm before/after self-admin 12.84 1 0 0 0 1e+00 Klhdc8b
Delta time in open arm before/after self-admin 26.67 1 0 0 0 1e+00 Zfand2b
Extinction: sum of active levers before priming 5.93 1 0 0 0 1e+00 Klhdc8b
Active lever presses in extinction session 6 16.82 2 0 0 0 1e+00 Klhdc8b Zfand2b
Delta ambulatory time before/after self-admin 6.19 1 0 0 0 1e+00 Zfand2b
Time in closed arm before self-admin 44.32 1 1 50 0 1e+00 Zfand2b
Time in closed arm after self-admin 5.85 1 0 0 0 1e+00 Klhdc8b
Time in open arm before self-admin 24.67 1 0 0 0 1e+00 Zfand2b
Sum of active levers in priming session hrs 5-6 6.97 1 0 0 0 1e+00 Zfand2b
Time to tail flick, vehicle, after self-admin 56.6 2 2 100 0 1e+00 Klhdc8b Zfand2b
Time to tail flick, test, before self-admin 10.68 1 0 0 0 1e+00 Zfand2b
Time to tail flick, test, after self-admin 5.63 1 0 0 0 1e+00 Zfand2b
Delta time to tail flick, vehicle, before/after SA 44.54 2 1 50 0 1e+00 Klhdc8b Zfand2b
Ambulatory time before self-admin 25.36 1 0 0 0 1e+00 Zfand2b
Ambulatory time after self-admin 5.4 2 0 0 0 1e+00 Klhdc8b Zfand2b
Total heroin consumption 18.89 1 0 0 0 1e+00 Klhdc8b
Area under the delay curve 18.01 2 1 50 0 1e+00 Klhdc8b Zfand2b
Delay disc. indifference point, 0s delay 17.2 2 1 50 0 1e+00 Klhdc8b Zfand2b
Delay disc. indifference point, 16s delay 41.08 2 1 50 0 1e+00 Klhdc8b Zfand2b
Delay disc. indifference point, 24s delay 27.43 1 0 0 0 1e+00 Zfand2b
Delay disc. indifference point, 4s delay 41.82 1 1 50 0 1e+00 Klhdc8b
Delay disc. indifference point, 8s delay 39.92 2 1 50 0 1e+00 Klhdc8b Zfand2b
Delay discount exponential model param 16.14 1 0 0 0 1e+00 Zfand2b
Delay discount hyperbolic model param 10.46 2 0 0 0 1e+00 Klhdc8b Zfand2b
Fecal boli incidents, locomotor time 1 96.73 2 1 50 0 1e+00 Klhdc8b Zfand2b
Time >=10cm from walls, locomotor time 1 43.35 2 1 50 0 1e+00 Klhdc8b Zfand2b
Bouts of movement, locomotor time 1 6.19 1 0 0 0 1e+00 Zfand2b
Rest time, locomotor task time 1 17.01 2 0 0 0 1e+00 Klhdc8b Zfand2b
Distance moved, locomotor task time 1 31.01 1 1 50 0 1e+00 Klhdc8b
Vertical activity count, locomotor time 1 73.36 2 2 100 0 1e+00 Klhdc8b Zfand2b
Bouts of movement, locomotor time 2 21.88 2 0 0 0 1e+00 Klhdc8b Zfand2b
Total resting periods, locomotor time 2 28.25 2 1 50 0 1e+00 Klhdc8b Zfand2b
Distance moved, locomotor task time 2 63.13 2 2 100 0 1e+00 Klhdc8b Zfand2b
Vertical activity count, locomotor time 2 34.04 2 1 50 0 1e+00 Klhdc8b Zfand2b
Weight adjusted by age 20.12 2 1 50 0 1e+00 Klhdc8b Zfand2b
Seeking ratio, delayed vs. immediate footshock 8.74 1 0 0 0 1e+00 Zfand2b
Locomotion in novel chamber post-restriction 14.04 1 0 0 0 1e+00 Zfand2b
Progressive ratio 7.25 1 0 0 0 1e+00 Klhdc8b
Food seeking constrained by brief footshock 13.85 2 0 0 0 1e+00 Klhdc8b Zfand2b
Seeking ratio, punishment vs. effort 4.47 2 0 0 0 1e+00 Klhdc8b Zfand2b
Run reversals in cocaine runway, females 21.48 2 1 50 0 1e+00 Klhdc8b Zfand2b
Latency to leave start box in cocaine runway 34.23 1 1 50 0 1e+00 Zfand2b
Latency to leave start box in cocaine runway, F 31.9 1 1 50 0 1e+00 Zfand2b
Cd content in liver 20.17 1 0 0 0 1e+00 Klhdc8b
Fe content in liver 40.39 1 1 50 0 1e+00 Klhdc8b
K content in liver 12.22 1 0 0 0 1e+00 Klhdc8b
Mg content in liver 15.79 1 0 0 0 1e+00 Klhdc8b
Mn content in liver 5.99 1 0 0 0 1e+00 Klhdc8b
Na content in liver 16.36 1 0 0 0 1e+00 Klhdc8b
Rb content in liver 51.88 1 1 50 0 1e+00 Klhdc8b
Se content in liver 8.45 1 0 0 0 1e+00 Klhdc8b
Sr content in liver 22.41 1 0 0 0 1e+00 Klhdc8b
Zn content in liver 9.95 1 0 0 0 1e+00 Klhdc8b

Associations by panel

Tissue RNA modality # hits % hits/tests Avg chisq
Adipose alternative polyA 0 0 1.12
Adipose alternative TSS 0 0 1.13
Adipose gene expression 0 0 1.11
Adipose isoform ratio 0 0 1.14
Adipose intron excision ratio 0 0 1.34
Adipose mRNA stability 0 0 1.12
BLA alternative polyA 0 0 1.05
BLA alternative TSS 0 0 1.19
BLA gene expression 0 0 1.18
BLA isoform ratio 0 0 1.12
BLA intron excision ratio 0 0 1.23
BLA mRNA stability 0 0 1.15
Brain alternative polyA 0 0 1.14
Brain alternative TSS 0 0 1.21
Brain gene expression 0 0 1.15
Brain isoform ratio 0 0 1.16
Brain intron excision ratio 0 0 1.25
Brain mRNA stability 0 0 1.12
Eye alternative polyA 0 0 0.99
Eye alternative TSS 0 0 1.33
Eye gene expression 0 0 1.18
Eye isoform ratio 0 0 1.14
Eye intron excision ratio 0 0 1.27
Eye mRNA stability 0 0 1.16
IL alternative polyA 0 0 0.98
IL alternative TSS 0 0 1.05
IL gene expression 0 0 1.22
IL isoform ratio 0 0 1.18
IL intron excision ratio 0 0 1.23
IL mRNA stability 0 0 1.2
LHb alternative polyA 0 0 0.95
LHb alternative TSS 0 0 1.15
LHb gene expression 0 0 1.19
LHb isoform ratio 0 0 1.02
LHb intron excision ratio 0 0 1.23
LHb mRNA stability 0 0 1.16
Liver alternative polyA 0 0 1.09
Liver alternative TSS 0 0 1.09
Liver gene expression 1 0 1.12
Liver isoform ratio 0 0 1.12
Liver intron excision ratio 0 0 1.14
Liver mRNA stability 0 0 1.1
NAcc alternative polyA 0 0 1.08
NAcc alternative TSS 0 0 1.19
NAcc gene expression 0 0 1.12
NAcc isoform ratio 0 0 1.13
NAcc intron excision ratio 0 0 1.23
NAcc mRNA stability 0 0 1.16
OFC alternative polyA 0 0 0.9
OFC alternative TSS 0 0 1.14
OFC gene expression 0 0 1.18
OFC isoform ratio 0 0 1.12
OFC intron excision ratio 0 0 1.25
OFC mRNA stability 0 0 1.17
PL alternative polyA 0 0 1.07
PL alternative TSS 0 0 1.19
PL gene expression 0 0 1.13
PL isoform ratio 0 0 1.12
PL intron excision ratio 1 0 1.21
PL mRNA stability 0 0 1.16
pVTA alternative polyA 0 0 1.09
pVTA alternative TSS 0 0 1.22
pVTA gene expression 0 0 1.18
pVTA isoform ratio 0 0 1.15
pVTA intron excision ratio 0 0 1.23
pVTA mRNA stability 0 0 1.21
RMTg alternative polyA 0 0 0.96
RMTg alternative TSS 0 0 1.13
RMTg gene expression 0 0 1.15
RMTg isoform ratio 0 0 1.09
RMTg intron excision ratio 0 0 1.21
RMTg mRNA stability 0 0 1.03