Acer3

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	gene expression	Acer3	0.68	0.1	0.0e+00	0.38	0.52	0.52	0.52	1.8e-44	1.4e-66	3.9e-67	2.7e-67
2	IC	mRNA stability	Acer3	0.1	0.07	2.0e-03	0.04	0.04	0.04	0.05	8.6e-03	8.0e-03	8.1e-03	4.0e-03
3	BLA	mRNA stability	Acer3	0.07	0.05	3.7e-03	0.01	0.04	0.02	0.03	1.0e-01	2.7e-03	2.9e-02	7.7e-03
4	Adipose	mRNA stability	Acer3	0.77	0.06	0.0e+00	0.23	0.39	0.39	0.38	4.6e-25	6.4e-46	1.2e-45	8.2e-44
5	Liver	gene expression	Acer3	0.37	0.13	3.8e-08	0.04	0.06	0.04	0.03	3.5e-05	8.0e-07	2.2e-05	9.8e-05

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5
Bone: apparent density	0.1	0.2	0.4	0.6	-0.1	0.3	-0.3	-0.5
Area under the delay curve	0.3	0.5	1.7	-0.4	-1.3	-0.7	-0.4	-0.3
BMI with tail	1.6	5.4	12.4	1.1	3.5	3.0	1.5	-1.5
BMI without tail	1.2	6.6	14.9	0.6	3.9	3.5	2.0	-1.2
Body weight	1.7	7.5	20.3	0.9	4.5	3.6	1.3	-1.3
Weight adjusted by age	0.2	0.5	0.7	-0.0	0.6	0.9	0.9	-0.7
Bone surface	0.5	0.9	1.6	-1.2	-1.1	-0.4	-1.2	-0.4
Bone volume	0.1	0.3	0.7	-0.4	-0.5	0.2	-0.3	-0.9
Breakpoint value in progressive ratio session	0.1	0.1	0.5	0.7	-0.1	-0.2	0.2	-0.2
Number of licking bursts	1.2	3.7	6.7	2.6	2.0	1.9	1.2	-1.7
Context. condit. distance diff. score	1.8	2.2	3.4	-1.4	-1.8	-1.4	-1.8	-0.1
Locomotion velocity, session 1	0.7	0.8	2.2	-0.2	-1.5	-1.2	0.5	0.3
Locomotion distance, session 1	0.9	1.1	1.6	-1.2	-0.7	-1.3	-0.9	1.1
Locomotion velocity, session 2	0.5	0.6	1.2	-0.7	-1.1	-0.5	1.1	0.1
Locomotion distance, session 2	0.3	0.4	1.1	-0.9	-0.1	-0.4	0.3	1.0
Locomotion velocity, session 3	0.2	0.3	0.6	-0.6	-0.8	-0.6	-0.1	0.2
Locomotion distance, session 3	1.1	1.3	2.4	-1.0	-1.6	-1.5	-1.0	0.2
Stereotopy head waving bouts, day 3	1.0	1.2	2.7	0.6	1.6	1.1	1.1	0.7
Stereotopy head waving duration, day 3	0.4	0.5	1.6	-0.8	0.1	-0.3	-0.2	1.3
Locomotion velocity, session 7	0.5	0.6	1.3	0.8	-0.9	0.1	0.4	-1.1
Locomotion distance, session 7	0.4	0.5	2.3	0.3	-0.5	0.3	0.2	-1.5
Stereotopy head waving bouts, day 7	1.9	2.3	3.9	-1.6	-1.2	-1.6	-1.0	2.0
Stereotopy head waving duration, day 7	1.7	2.1	3.4	-1.8	-0.9	-1.3	-1.0	1.8
Locomotion velocity, session 8	3.0	3.6	10.0	-1.5	-3.2	-1.8	-1.4	-0.6
Locomotion distance, session 8	1.3	1.8	3.1	-1.8	-1.5	-1.5	-1.1	0.7
Degree of sensitization distance	1.2	1.3	2.7	0.6	1.3	1.6	0.8	-1.0
Degree of sensitization stereotypy	4.1	4.5	5.7	-2.3	-2.0	-2.4	-1.9	2.1
Conditioned locomotion	0.1	0.1	0.3	0.0	-0.6	-0.5	0.2	0.2
Cocaine response after cond. corrected	0.8	1.2	3.9	1.3	-0.1	0.6	0.5	-2.0
Cocaine response after cond. not corrected	0.2	0.3	0.9	0.5	-0.4	-0.2	-0.5	-0.9
Cocaine response before conditioning	2.1	2.6	5.7	-1.4	-0.4	-1.4	-1.8	2.4
Saline control response	0.9	1.3	2.7	-1.6	0.3	-0.5	-1.2	1.5
Bone: connectivity density	0.3	0.5	1.4	-0.1	-1.2	-0.7	-0.9	-0.2
Bone: cortical apparent density	0.6	0.9	1.5	1.2	0.7	0.8	1.0	-1.0
Bone: cortical area	0.4	0.7	1.3	0.1	0.7	0.9	-1.0	-1.1
Bone: cortical porosity	1.2	1.4	2.8	-1.1	-0.5	-1.2	-1.1	1.7
Bone: cortical porosity	1.2	1.4	3.5	-1.1	-0.5	-1.2	-0.7	1.9
Bone: cortical thickness	0.6	1.0	1.6	1.3	0.8	0.9	-0.5	-1.3
Bone: cortical thickness	0.2	0.3	0.7	-0.1	-0.1	-0.1	-0.8	-0.8
Bone: cortical tissue density	0.5	0.8	1.4	1.2	0.6	0.7	1.1	-0.8
Condit. Reinf. active minus inactive responses	0.8	0.9	1.8	0.5	1.3	1.3	0.2	-0.9
Condit. Reinf. active-inactive response ratio	0.5	0.5	1.4	0.0	1.2	1.0	-0.3	-0.4
Condit. Reinf. active responses	0.7	0.8	1.5	0.7	1.2	1.1	0.6	-0.7
Condit. Reinf. inactive responses	0.2	0.2	0.7	0.6	0.2	0.2	0.8	-0.3
Incentive salience index mean	0.5	0.7	1.3	0.5	0.7	1.0	0.6	-1.1
Condit. Reinf. lever presses	0.2	0.3	0.6	0.1	-0.7	0.1	0.8	-0.8
Condit. Reinf. active minus inactive responses	1.8	2.8	7.4	-2.7	-0.3	-0.9	-2.2	1.0
Condit. Reinf. active-inactive response ratio	0.2	0.3	0.7	-0.8	-0.4	-0.3	-0.7	-0.5
Condit. Reinf. active responses	3.0	4.3	12.0	-3.5	-0.2	-1.0	-2.4	1.5
Condit. Reinf. inactive responses	1.9	2.8	7.6	-2.8	0.2	-0.6	-1.2	2.1
Condit. Reinf. lever presses	10.4	15.1	31.3	-5.6	-2.3	-3.2	-4.4	3.0
Condit. Reinf. lever reinforcers received	3.5	4.9	13.4	-3.7	-0.4	-1.2	-2.7	1.6
Conditioned reinforcement - actives	0.4	1.6	2.5	-1.4	-1.6	-1.3	-1.2	0.7
Conditioned reinforcement - inactives	0.1	0.4	1.0	0.1	-1.0	-0.7	-0.2	0.4
Conditioned locomotion	2.7	4.1	6.1	-1.9	-2.5	-2.3	-1.8	1.5
Patch foraging indifference point 0 sec	1.7	4.7	8.9	-3.0	-1.0	-1.5	-2.5	2.1
Patch foraging indifference point AUC	0.1	0.1	0.5	-0.1	0.1	0.3	-0.0	-0.7
Delay disc. indifference point, 0s delay	0.4	0.5	1.4	-1.2	-0.4	-0.5	-0.3	0.6
Delay disc. indifference point, 16s delay	0.4	0.5	2.1	-0.0	-1.4	-0.7	-0.1	-0.3
Delay disc. indifference point, 2s delay	1.0	1.1	2.1	-1.4	-0.8	-1.1	-0.9	1.0
Delay disc. indifference point, 24s delay	0.5	0.7	1.9	1.2	-0.2	0.5	0.5	-1.4
Delay disc. indifference point, 4s delay	0.5	0.5	1.3	-1.1	-0.9	-0.4	0.2	-0.2
Delay disc. indifference point, 8s delay	0.4	0.7	2.2	-0.4	-1.5	-0.7	-0.8	-0.3
Indifference point function ln k	0.8	2.4	3.4	-1.5	-1.2	-1.7	-1.5	1.8
Indifference point function log k	0.8	2.4	3.4	-1.5	-1.2	-1.7	-1.5	1.8
Patch foraging total patch changes 0 sec	1.4	4.1	7.7	-2.8	-1.0	-1.5	-2.5	1.9
Patch foraging total patch changes 12 sec	0.2	0.3	1.0	-1.0	0.0	0.3	-0.6	0.0
Patch foraging total patch changes 18 sec	0.3	0.6	2.6	-1.6	-0.4	-0.1	-0.5	0.2
Patch foraging total patch changes 24 sec	0.0	0.2	0.7	-0.8	0.2	0.1	0.1	0.2
Patch foraging total patch changes 6 sec	1.1	1.8	5.2	-1.3	-0.3	-0.9	-2.3	1.1
Patch foraging time to switch 0 sec	0.7	2.7	7.1	2.7	0.9	1.2	1.8	-0.9
Patch foraging water rate 0 sec	0.8	3.1	7.0	-2.6	-1.3	-1.4	-1.8	1.2
Patch foraging water rate 12 sec	0.5	2.2	4.5	-2.1	-1.2	-1.4	-1.1	1.4
Patch foraging water rate 18 sec	0.1	0.3	1.2	-1.1	-0.4	-0.4	0.0	0.1
Patch foraging water rate 24 sec	1.2	1.7	2.9	-1.4	-1.7	-1.6	-1.0	0.7
Patch foraging water rate 6 sec	0.8	1.2	1.7	-1.1	-1.3	-1.2	-0.9	0.8
Seeking ratio, delayed vs. immediate footshock	1.2	1.7	3.3	1.7	-0.2	0.8	1.2	-1.8
Distance traveled before self-admin	0.2	0.4	0.7	0.8	0.8	0.4	0.4	-0.4
Distance traveled after self-admin	0.2	0.4	0.8	0.9	0.6	-0.3	0.1	0.9
Extensor digitorum longus weight	0.5	1.9	4.1	0.9	0.9	1.8	0.9	-2.0
Bone: elastic displacement	0.5	0.7	2.0	1.4	-0.0	0.3	0.1	-1.1
Bone: elastic work	0.7	0.9	2.6	1.6	-0.7	-0.1	-0.2	-1.2
Bone: endosteal estimation	0.1	0.3	1.1	-1.0	0.2	0.6	0.2	-0.5
Bone: endosteal perimeter	0.3	0.8	3.4	-1.8	-0.7	-0.1	-0.1	-0.2
Epididymis fat weight	0.7	3.8	7.0	1.8	2.6	2.3	1.1	-1.4
Delta time in closed arm before/after self-admin	1.6	1.5	4.0	1.1	0.2	1.1	1.1	-2.0
Delta time in open arm before/after self-admin	0.6	0.8	2.6	-1.6	-0.3	-0.5	-0.8	0.5
Diff in mean of infusions in LGA sessions	1.7	3.1	7.0	2.7	1.7	1.3	1.6	-1.2
Delay discount exponential model param	0.4	0.5	1.5	0.4	1.2	0.7	0.3	0.2
Extinction: sum of active levers before priming	0.1	0.1	0.2	-0.3	0.1	0.2	0.4	-0.3
Active lever presses in extinction session 6	4.8	4.9	9.2	-1.9	-1.1	-2.5	-2.0	3.0
Bone: final force	0.5	0.8	3.1	0.4	-0.3	-0.2	-1.8	-0.7
Bone: final moment	0.4	0.6	2.8	0.2	-0.2	-0.1	-1.7	-0.6
Food consumed during 24 hour testing period	2.0	3.9	6.3	-2.5	-1.9	-2.1	-0.3	2.3
Glucose	0.2	0.3	1.2	0.1	0.1	0.4	0.3	-1.1
Heart weight	0.4	0.6	2.1	-0.8	-0.1	-0.4	-1.5	0.4
Delay discount hyperbolic model param	0.3	0.4	1.4	0.5	1.2	0.6	0.3	0.3
Intermittent access intake day 1-15 change	0.6	3.2	3.8	-1.8	-1.9	-2.0	-1.7	1.6
Intermittent access intake escalation	0.7	3.7	4.4	-1.9	-2.0	-2.1	-1.9	1.5
Intermittent access intake escalation 2	1.0	1.7	2.0	-1.4	-1.4	-1.3	-1.3	1.1
Intermitt. access day 1 inactive lever presses	0.1	0.7	2.5	1.6	0.1	0.3	0.9	-0.5
Intermitt. access day 15 inactive lever presses	0.1	0.7	2.6	1.6	0.4	0.4	0.7	-0.3
Intermitt. access escalation Index	0.0	0.1	0.2	0.4	-0.2	-0.2	-0.3	-0.2
Intermittent access day 1 total infusions	0.3	0.8	1.9	-0.9	-1.4	-0.9	-0.7	0.1
Intermittent access day 15 total infusions	1.7	4.1	7.8	-2.0	-2.8	-2.2	-1.8	1.0
Intermittent access terminal intake (last 3 days)	1.7	2.9	5.1	-1.8	-2.2	-1.7	-1.6	1.0
Intermittent access total infusions	1.1	1.3	3.0	-1.3	-1.7	-1.0	-0.9	0.1
Intermittent access day 1 locomotion	0.3	0.6	1.8	-0.3	-1.3	-0.8	-0.6	0.2
Intermittent access day 15 total locomotion	0.7	2.8	3.3	-1.7	-1.8	-1.8	-1.4	1.7
Intermittent access total locomotion	0.8	1.0	1.8	-1.1	-1.3	-0.9	-0.9	0.7
Intermittent access standard deviation	0.0	0.1	0.3	-0.5	0.1	0.5	0.2	-0.2
Left kidney weight	0.3	2.5	5.3	-0.1	2.3	2.0	1.8	-0.0
Right kidney weight	0.4	2.8	6.5	-0.3	2.6	2.0	1.7	0.0
Cocaine induced anxiety	0.6	1.7	3.1	1.8	1.2	1.4	1.1	-0.8
Post-drug Anxiety	1.0	1.2	2.3	1.5	0.6	1.0	1.0	-1.1
Baseline Anxiety	0.3	0.5	1.3	-0.7	-1.2	-0.7	-0.3	-0.4
Tail length	0.8	4.2	8.5	-0.3	2.9	2.7	2.1	-0.8
Length with tail	0.9	3.8	11.1	0.1	3.3	2.6	1.1	-0.5
Length without tail	0.2	0.9	3.2	0.7	1.8	0.8	0.1	0.5
Times rat made contact with spout	0.9	1.1	2.5	0.5	1.1	1.2	1.6	-0.3
Lifetime Intake	1.5	1.9	4.1	-1.5	-2.0	-1.3	-1.1	0.4
Liver weight, left	0.7	1.2	2.3	0.3	1.5	1.4	1.0	-0.7
Liver weight, right	3.3	5.7	9.4	1.5	3.1	2.9	2.6	-1.3
Locomotor activity	0.7	1.1	3.4	-1.3	0.3	-0.1	0.4	1.8
Locomotor testing distance	0.3	0.8	2.2	-1.5	0.6	0.5	0.3	1.1
Locomotor testing rearing	0.3	1.2	3.0	-0.4	1.7	1.5	0.9	0.3
Locomotion in novel chamber	1.3	1.7	2.4	-1.4	-1.6	-1.4	-1.2	0.9
Locomotion in novel chamber post-restriction	1.6	4.8	6.5	-2.5	-2.0	-2.4	-2.2	1.7
Fecal boli incidents, locomotor time 1	0.6	1.6	3.9	-1.0	-2.0	-1.4	-0.9	0.2
Change in fecal boli incidents, locomotor task	0.3	0.3	0.8	0.6	0.9	0.5	0.4	0.3
Time >=10cm from walls, locomotor time 1	1.9	2.3	3.0	-1.7	-1.4	-1.7	-1.5	1.3
Bouts of movement, locomotor time 1	0.1	0.1	0.3	-0.5	-0.2	-0.5	-0.2	-0.1
Total resting periods, locomotor time 1	0.2	0.2	0.5	-0.3	-0.6	-0.7	-0.3	-0.1
Rest time, locomotor task time 1	0.2	0.4	1.0	-0.1	-1.0	-0.9	-0.2	-0.1
Distance moved, locomotor task time 1	0.2	0.4	1.1	0.0	0.6	1.1	0.5	-0.7
Vertical activity count, locomotor time 1	0.0	0.2	0.4	-0.2	0.3	0.6	-0.3	-0.3
Time >=10cm from walls, locomotor time 2	0.2	0.5	1.8	-1.3	-0.3	-0.5	-0.5	0.5
Bouts of movement, locomotor time 2	0.2	0.6	1.5	-1.2	-0.5	-0.4	-0.0	0.9
Total resting periods, locomotor time 2	0.1	0.4	0.9	-1.0	-0.5	-0.4	0.0	0.8
Rest time, locomotor task time 2	0.4	0.7	2.3	1.5	0.5	0.6	0.6	-0.7
Distance moved, locomotor task time 2	0.4	0.6	2.5	-1.6	-0.4	-0.3	-0.3	0.3
Vertical activity count, locomotor time 2	0.1	0.2	0.7	-0.9	0.0	0.3	-0.2	-0.3
Light reinforcement 1	0.5	2.3	5.0	1.8	2.2	1.4	0.8	-0.7
Light reinforcement 2	0.2	0.5	1.0	-0.1	0.8	-0.4	-0.6	1.0
Bone: marrow area	0.1	0.3	0.8	-0.9	0.3	0.6	0.2	-0.5
Bone: maximum diameter	0.4	0.8	2.2	-1.5	-0.1	0.0	-1.3	-0.1
Bone: maximum force	0.5	1.1	4.3	0.2	-0.6	-0.5	-2.1	-0.7
Bone: maximum moment	0.5	0.9	3.8	0.0	-0.5	-0.4	-1.9	-0.5
Mean time between licks in bursts	0.2	1.2	4.6	-2.1	-0.0	-0.0	0.3	1.1
Mean num. licks in bursts	0.9	2.4	5.5	-2.3	-1.6	-1.4	-0.7	1.4
Cd content in liver	1.4	1.6	2.4	1.2	1.3	1.4	0.8	-1.5
Co content in liver	0.2	0.2	0.5	-0.6	-0.1	0.3	0.7	-0.3
Cu content in liver	1.1	1.3	2.9	-0.1	1.3	1.3	1.7	-0.3
Fe content in liver	0.1	0.1	0.2	0.3	-0.1	-0.0	-0.4	-0.5
K content in liver	0.3	0.3	1.2	0.2	0.1	0.3	1.1	0.6
Mg content in liver	0.3	0.3	1.0	-0.5	-0.3	-0.4	0.3	1.0
Mn content in liver	0.3	0.3	0.4	0.6	-0.5	-0.6	-0.1	0.6
Na content in liver	1.5	1.7	3.6	-1.1	-0.9	-1.3	-1.1	1.9
Rb content in liver	0.1	0.1	0.2	-0.0	0.4	0.4	-0.0	-0.2
Se content in liver	1.8	2.1	7.1	2.7	0.7	0.7	1.3	-0.7
Sr content in liver	0.3	0.2	0.4	-0.3	-0.6	-0.6	-0.5	-0.0
Zn content in liver	0.4	0.5	1.9	-1.4	0.3	0.2	0.3	0.4
Bone: minimum diameter	0.7	1.4	2.8	0.2	1.3	1.7	0.7	-1.4
Time in familiar zone, hab. session 1	0.1	0.1	0.4	0.2	-0.1	0.2	0.6	-0.5
Time in novel zone, hab. session 1	0.3	0.3	0.7	0.4	0.8	0.7	-0.0	-0.4
Total zone transitions, hab. session 1	0.8	1.1	2.6	-0.4	-0.0	-0.9	-1.6	1.4
Total locomotion distance, hab. session 1	3.1	4.4	12.0	1.6	3.5	2.4	1.2	-0.0
Locomotion velocity, hab. session 1	2.4	3.4	10.0	1.3	3.2	2.1	0.9	0.2
Time in familiar zone, hab. session 2	0.3	0.3	1.1	-1.1	-0.5	-0.0	0.2	0.0
Time in novel zone, hab. session 2	0.1	0.1	0.2	0.4	-0.0	-0.2	-0.2	-0.2
Total zone transitions, hab. session 2	2.0	2.6	5.3	-1.1	-0.1	-1.4	-2.3	2.1
Total locomotion distance, hab. session 2	1.9	2.5	8.5	0.9	2.9	1.7	0.4	0.4
Locomotion velocity, hab. session 2	2.2	2.9	9.7	0.9	3.1	1.9	0.5	0.4
Novel to familiar place preference ratio	0.3	0.4	1.0	-0.3	0.3	-0.4	-1.0	0.8
Novelty place preference	0.1	0.2	0.4	-0.3	0.1	-0.3	-0.7	0.5
Time in novel zone, NPP test	0.2	0.3	0.6	-0.4	-0.1	-0.5	-0.8	0.4
Total zone transitions, NPP test	0.5	0.8	1.6	-0.4	-0.8	-1.2	-1.2	0.6
Total locomotion distance, NPP test	1.8	2.5	6.1	1.5	2.5	1.8	0.9	-0.5
Locomotion velocity, NPP test	2.3	3.2	7.9	1.7	2.8	2.0	1.0	-0.5
Intraocular pressure	1.7	2.8	8.3	-0.7	-2.9	-1.7	-1.3	-0.8
Delta distance traveled before/after self-admin	1.3	1.4	4.2	-0.8	-0.5	-1.1	-0.9	2.0
Delta ambulatory time before/after self-admin	0.8	1.4	3.4	-0.8	-0.6	-1.3	-1.0	1.9
Parametrial fat weight	0.8	1.9	6.9	0.9	2.6	1.2	-0.6	0.0
Pavlov. Cond. lever latency	0.4	0.5	1.3	1.0	1.1	0.5	-0.2	-0.0
Pavlov. Cond. magazine entry latency	0.7	0.9	2.6	-1.6	-0.5	-0.5	-1.1	0.5
Pavlov. Cond. change in total contacts	0.3	0.3	0.8	-0.7	-0.9	-0.5	-0.4	-0.2
Pavlov. Cond. index score	0.4	0.5	1.8	-1.3	-0.8	-0.3	-0.1	0.1
Pavlov. Cond. latency score	0.4	0.5	1.7	-1.3	-0.7	-0.3	-0.3	0.2
Pavlov. Cond. lever contacts	0.3	0.3	0.7	-0.7	-0.8	-0.1	0.6	-0.2
Pavlov. Cond. magazine entry number	0.6	0.8	2.4	1.6	0.6	0.5	0.9	-0.4
Pavlov. Cond. intertrial magazine entries	1.2	1.4	3.4	1.3	0.9	0.9	1.9	-0.5
Pavlov. Cond. lever-magazine prob. diff.	0.4	0.5	1.4	-1.2	-0.9	-0.3	0.0	-0.0
Pavlov. Cond. response bias	0.2	0.2	0.6	-0.8	-0.7	-0.1	0.2	-0.1
Pavlov. Cond. lever latency	12.4	17.5	33.5	5.8	3.0	3.7	4.6	-3.1
Pavlov. Cond. magazine entry latency	4.2	5.9	9.8	-2.7	-2.4	-2.4	-3.1	1.0
Pavlov. Cond. change in total contacts	4.6	11.1	22.3	-4.7	-2.0	-2.9	-3.8	2.6
Pavlov. Cond. index score	8.3	13.0	23.8	-4.9	-2.8	-3.3	-4.1	2.3
Pavlov. Cond. latency score	7.7	12.3	21.2	-4.6	-2.8	-3.3	-4.0	2.3
Pavlov. Cond. lever contacts	10.7	15.7	31.0	-5.6	-2.7	-3.5	-4.4	3.0
Pavlov. Cond. magazine entry number	5.5	7.1	10.3	3.2	3.2	2.7	2.8	-0.4
Pavlov. Cond. intertrial magazine entries	0.7	1.6	4.0	0.1	2.0	1.6	1.2	0.4
Pavlov. Cond. lever-magazine prob. diff.	7.7	11.8	21.9	-4.7	-2.7	-3.1	-3.9	2.2
Pavlov. Cond. response bias	11.6	16.0	30.8	-5.6	-3.1	-3.6	-4.4	2.6
Time in closed arm before self-admin	0.8	1.3	1.9	-0.9	-1.4	-1.2	-0.9	1.2
Time in closed arm after self-admin	0.7	0.8	2.4	0.7	-1.6	-0.6	0.0	-0.8
Time in open arm before self-admin	1.2	1.5	2.6	1.6	1.4	1.1	1.0	-0.9
Time in open arm after self-admin	0.6	0.7	2.4	-0.4	1.5	0.9	0.0	0.1
Bone: periosteal estimation	0.2	0.5	1.2	-0.7	0.3	0.7	-0.5	-1.1
Bone: periosteal perimeter	0.2	0.3	1.3	-1.1	0.1	0.4	-0.2	-0.2
Bone: post-yield work	0.2	0.4	1.6	-0.2	0.1	-0.1	-1.3	0.4
Progressive ratio test 1 active lever presses	0.3	0.4	1.3	0.1	-1.1	-0.8	-0.6	0.0
Progressive ratio test 1 breakpoint	0.3	0.4	1.3	0.1	-1.1	-0.7	-0.6	0.0
Progressive ratio test 1 inactive lever presses	0.1	0.2	0.4	0.6	-0.6	-0.3	-0.5	0.2
Progressive ratio test 2 active lever presses	0.4	0.6	1.3	-0.9	-1.1	-0.6	-0.5	-0.4
Progressive ratio test 2 breakpoint	0.5	0.6	1.4	-0.9	-1.2	-0.6	-0.5	-0.4
Progressive ratio test 2 inactive lever presses	0.1	0.3	1.0	-0.4	-1.0	-0.3	-0.3	-0.1
Incentive Sensitization - Responses	0.2	0.6	1.7	-1.3	-0.8	-0.5	-0.6	-0.1
Incentive Sensitization - Breakpoint	0.2	0.6	1.6	-1.3	-0.8	-0.5	-0.6	-0.1
Sum of active levers in priming session hrs 5-6	0.5	0.5	1.4	-0.5	0.8	-0.2	0.1	1.2
Progressive ratio	0.3	0.9	1.8	-0.5	-1.4	-1.1	-1.1	-0.3
Food seeking constrained by brief footshock	1.3	1.6	3.7	-1.9	0.8	-0.3	-0.5	1.8
Seeking ratio, punishment vs. effort	0.6	1.3	3.0	-0.8	1.7	0.9	0.6	1.3
Retroperitoneal fat weight	4.6	20.6	42.3	3.2	6.5	5.6	3.2	-2.9
Reaction time number correct	0.3	1.2	4.3	-0.5	-0.1	-1.1	-0.7	2.1
Reaction time mean minus median	0.1	0.6	1.9	-1.4	0.2	-0.1	-0.7	0.7
Reaction time mean minus median AUC	0.2	1.1	2.6	-1.6	-0.1	-0.6	-1.1	1.3
Reaction time num false alarms	1.9	3.2	5.3	2.3	1.3	1.8	1.3	-2.0
Reaction time num false alarms AUC	0.7	1.7	3.0	1.7	0.4	1.1	1.2	-1.6
Reaction time trials correct on left	0.3	1.2	4.3	-0.5	-0.1	-1.1	-0.7	2.1
Reaction time trials on left	0.4	1.3	4.4	-0.5	-0.1	-1.1	-0.8	2.1
Reaction time mean	0.2	0.4	1.0	0.3	1.0	0.8	0.2	-0.4
Reaction time mean AUC	0.2	0.4	0.5	0.6	0.7	0.7	0.4	-0.7
Median of all reaction times	0.3	0.5	0.7	0.8	0.9	0.8	0.4	-0.7
Reaction time omissions	0.0	0.1	0.1	-0.2	0.1	0.3	-0.2	-0.3
Reaction time false alarm rate	2.0	2.8	6.7	1.9	0.5	1.5	1.1	-2.6
Reaction time premature initiation rate	0.6	0.9	2.0	-0.6	1.4	1.4	0.1	-0.0
Reaction time premature initiations	0.2	0.7	1.2	-1.0	1.0	0.6	-0.4	1.1
Std. dev. reaction times	0.1	0.3	0.5	-0.6	0.7	0.7	0.1	-0.2
Reaction time trials completed	0.4	1.3	4.4	-0.5	-0.1	-1.1	-0.8	2.1
Reaction time trials AUC	0.3	1.2	4.3	-0.5	0.1	-0.9	-0.8	2.1
Run reversals in cocaine runway, females	2.6	2.9	4.4	1.0	1.5	2.1	1.6	-2.0
Run reversals in cocaine runway, males	0.7	0.8	2.6	-0.3	-1.6	-0.8	-0.4	-0.7
Latency to leave start box in cocaine runway	1.1	1.6	2.8	1.7	1.3	1.1	1.4	-0.6
Latency to leave start box in cocaine runway, F	2.0	2.5	3.3	1.8	1.6	1.6	1.7	-1.0
Latency to leave start box in cocaine runway, M	0.1	0.1	0.1	0.2	-0.4	-0.4	0.1	0.3
Std. dev. time between licks in bursts	0.6	1.1	2.1	-0.7	1.4	0.9	1.0	0.9
Total sessions with >9 infusions	1.6	2.0	3.0	-1.6	-1.7	-1.3	-1.4	0.8
Short access day 1 total inactive lever presses	0.2	0.4	1.3	-0.4	-1.2	-0.6	0.1	-0.2
Short access day 10 total inactive lever presses	0.1	0.8	2.0	1.4	0.9	0.7	0.7	-0.0
Short access day 1 total infusions	0.9	1.9	4.3	-2.1	-1.4	-1.1	-1.1	0.8
Short access day 10 total infusions	0.5	0.9	1.8	-1.1	-1.3	-0.9	-0.8	-0.0
Short access total infusions	1.5	2.1	4.1	-1.6	-2.0	-1.4	-1.2	0.5
Short access day 1 locomotion	2.4	4.0	5.3	-2.1	-2.3	-2.2	-2.1	1.3
Short access day 10 total locomotion	0.3	1.1	2.0	-1.4	-1.2	-0.9	-0.8	0.8
Short access total locomotion	0.9	1.4	1.5	-1.1	-1.2	-1.2	-1.1	1.2
One hour access (0.3 mA shock)	0.5	0.6	1.2	-1.1	-1.0	-0.6	-0.6	0.2
Compulsive drug intake	0.1	0.2	0.5	0.4	0.2	-0.4	-0.2	0.7
One hour access (shock baseline)	0.6	1.6	3.2	-1.6	-1.8	-1.2	-1.0	0.4
Social response proportion	0.7	0.9	1.8	0.7	1.3	1.1	1.0	0.5
Social responses	1.6	2.1	3.5	1.2	1.9	1.8	1.4	-0.7
Social time	0.9	1.5	3.5	1.9	1.3	0.9	1.1	-0.3
Soleus weight	1.1	3.4	6.2	0.9	2.2	2.5	1.7	-1.5
Bone: stiffness	0.5	0.8	2.8	0.9	0.2	0.1	-1.7	-0.7
Tibialis anterior weight	0.1	0.3	0.9	-0.1	0.9	0.7	-0.2	0.2
Time to tail flick, vehicle, before self-admin	0.1	0.2	0.5	0.3	0.1	0.5	-0.1	-0.7
Time to tail flick, vehicle, after self-admin	0.4	0.9	1.4	-1.2	-1.1	-0.8	-1.0	0.5
Time to tail flick, test, before self-admin	0.4	0.4	1.6	-0.1	0.4	0.7	0.0	-1.2
Time to tail flick, test, after self-admin	0.4	0.4	0.7	-0.1	0.5	0.8	0.7	-0.8
Delta time to tail flick, vehicle, before/after SA	1.5	1.6	1.9	-1.4	-1.4	-1.4	-1.1	1.1
Delta time to tail flick, test, before/after SA	0.2	0.2	0.5	0.4	0.4	0.1	0.5	0.7
Tibia length	1.3	3.7	7.1	-2.0	-1.1	-1.9	-2.7	1.7
Ambulatory time before self-admin	0.1	0.2	0.7	0.9	0.1	-0.1	0.2	-0.5
Ambulatory time after self-admin	0.3	0.5	1.3	0.4	-0.1	-0.9	-0.3	1.1
Bone: tissue strength	1.1	1.1	4.0	0.7	-0.1	-0.7	-2.0	0.8
Total heroin consumption	0.0	0.0	0.2	-0.0	0.4	-0.0	-0.0	0.1
Bone: trabecular number	0.5	1.0	2.6	1.6	-0.2	0.5	0.1	-1.4
Bone: trabecular spacing	1.1	1.6	3.0	-1.6	-0.5	-1.2	-0.7	1.7
Bone: trabecular thickness	0.9	1.2	2.4	1.0	0.7	1.3	0.7	-1.5
Bone: trabecular tissue density	1.4	2.4	6.9	1.3	2.6	1.6	0.8	-0.0
Water consumed over 24 hours	0.3	0.6	1.5	1.0	0.3	0.6	1.2	-0.4
Number of responses in last shaping day	2.3	3.0	4.3	1.7	1.8	2.1	1.4	-1.6