Acer3

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	gene expression	Acer3	0.69	0.1	0.0e+00	0.38	0.51	0.52	0.52	3.8e-44	8.2e-66	1.5e-66	1.2e-66
2	Adipose	mRNA stability	Acer3	0.78	0.05	0.0e+00	0.24	0.4	0.39	0.38	5.5e-26	8.9e-47	2.3e-46	5.0e-45
3	Liver	gene expression	Acer3	0.42	0.13	1.1e-08	0.05	0.06	0.05	0.05	3.2e-06	1.5e-07	1.1e-06	3.5e-06

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3
Bone: apparent density	0.1	0.2	0.3	0.6	-0.1	-0.5
Area under the delay curve	0.1	0.1	0.1	-0.3	-0.3	-0.4
BMI with tail	0.2	0.7	1.0	1.0	0.6	-0.8
BMI without tail	1.1	2.3	5.4	1.0	2.3	-0.6
Body weight	0.3	1.1	2.2	0.7	1.5	-0.7
Weight adjusted by age	0.4	0.5	0.8	-0.2	0.9	-0.8
Bone surface	0.4	0.8	1.3	-1.1	-1.0	-0.3
Bone volume	0.1	0.3	0.5	-0.5	-0.1	-0.7
Breakpoint value in progressive ratio session	0.2	0.2	0.4	0.4	-0.0	-0.7
Number of licking bursts	3.4	4.0	7.0	2.6	1.4	-1.8
Context. condit. distance diff. score	1.6	1.9	4.2	-1.3	-2.0	-0.1
Locomotion velocity, session 1	0.1	0.1	0.1	-0.3	0.4	0.2
Locomotion distance, session 1	0.9	1.2	1.3	-1.1	-1.0	1.1
Locomotion velocity, session 2	0.6	0.6	1.2	-0.9	1.1	0.1
Locomotion distance, session 2	0.5	0.7	1.2	-0.9	0.2	1.1
Locomotion velocity, session 3	0.2	0.2	0.5	-0.7	-0.1	0.3
Locomotion distance, session 3	0.6	0.6	0.9	-0.9	-1.0	0.1
Stereotopy head waving bouts, day 3	0.7	0.9	1.5	0.4	1.2	1.0
Stereotopy head waving duration, day 3	0.7	0.8	1.8	-0.8	-0.2	1.3
Locomotion velocity, session 7	0.7	0.7	1.6	0.7	0.3	-1.3
Locomotion distance, session 7	0.8	1.0	2.9	0.4	0.1	-1.7
Stereotopy head waving bouts, day 7	2.2	2.5	4.3	-1.6	-0.8	2.1
Stereotopy head waving duration, day 7	2.3	2.7	4.0	-2.0	-0.7	1.9
Locomotion velocity, session 8	1.4	1.6	2.3	-1.5	-1.5	-0.7
Locomotion distance, session 8	1.1	1.6	2.8	-1.7	-1.2	0.7
Degree of sensitization distance	0.8	0.8	1.1	0.7	0.8	-1.1
Degree of sensitization stereotypy	4.1	4.5	6.0	-2.4	-1.7	2.1
Conditioned locomotion	0.0	0.0	0.0	-0.1	-0.1	0.2
Cocaine response after cond. corrected	1.6	1.8	3.5	1.2	0.7	-1.9
Cocaine response after cond. not corrected	0.3	0.3	0.7	0.4	-0.2	-0.8
Cocaine response before conditioning	2.6	3.2	5.5	-1.4	-1.5	2.4
Saline control response	1.3	1.7	3.1	-1.8	-0.3	1.3
Bone: connectivity density	0.2	0.3	0.7	-0.2	-0.9	-0.1
Bone: cortical apparent density	0.9	1.2	1.5	1.1	1.2	-1.0
Bone: cortical area	0.3	0.4	0.6	-0.1	-0.8	-0.8
Bone: cortical porosity	2.3	2.5	3.8	-1.6	-1.1	1.9
Bone: cortical porosity	1.9	2.1	3.8	-1.4	-0.6	2.0
Bone: cortical thickness	0.3	0.6	0.8	0.9	-0.3	-0.9
Bone: cortical thickness	0.5	0.6	1.3	-0.3	-1.2	-0.7
Bone: cortical tissue density	0.9	1.2	1.7	1.0	1.3	-0.9
Condit. Reinf. active minus inactive responses	0.2	0.3	0.4	0.4	0.4	-0.7
Condit. Reinf. active-inactive response ratio	0.0	0.0	0.1	0.0	-0.1	-0.3
Condit. Reinf. active responses	0.3	0.4	0.7	0.6	0.8	-0.5
Condit. Reinf. inactive responses	0.3	0.3	0.8	0.4	0.9	-0.2
Incentive salience index mean	0.4	0.5	0.9	0.3	0.8	-1.0
Condit. Reinf. lever presses	0.4	0.5	0.9	-0.0	0.9	-0.8
Condit. Reinf. active minus inactive responses	3.0	3.7	6.4	-2.5	-1.8	1.1
Condit. Reinf. active-inactive response ratio	0.4	0.4	0.6	-0.8	-0.7	-0.4
Condit. Reinf. active responses	4.1	5.7	10.8	-3.3	-2.0	1.6
Condit. Reinf. inactive responses	3.5	4.3	7.5	-2.7	-0.8	2.2
Condit. Reinf. lever presses	14.4	19.6	31.3	-5.6	-4.1	3.3
Condit. Reinf. lever reinforcers received	4.9	6.9	12.6	-3.5	-2.2	1.8
Conditioned reinforcement - actives	2.1	2.1	3.1	-1.8	-1.5	1.0
Conditioned reinforcement - inactives	0.1	0.1	0.1	0.3	0.4	-0.3
Conditioned locomotion	1.9	2.3	3.2	-1.8	-1.6	1.1
Patch foraging indifference point 0 sec	4.3	7.0	9.9	-3.1	-2.3	2.4
Patch foraging indifference point AUC	0.1	0.1	0.3	0.0	-0.2	-0.5
Delay disc. indifference point, 0s delay	0.4	0.4	0.8	-0.9	-0.2	0.6
Delay disc. indifference point, 16s delay	0.0	0.0	0.1	-0.1	-0.2	-0.2
Delay disc. indifference point, 2s delay	1.0	1.2	1.9	-1.4	-0.9	0.9
Delay disc. indifference point, 24s delay	1.1	1.0	2.0	1.0	0.3	-1.4
Delay disc. indifference point, 4s delay	0.3	0.3	0.8	-0.9	0.3	-0.2
Delay disc. indifference point, 8s delay	0.3	0.3	0.6	-0.5	-0.8	-0.2
Indifference point function ln k	2.0	2.7	3.2	-1.6	-1.5	1.8
Indifference point function log k	2.0	2.7	3.2	-1.6	-1.5	1.8
Patch foraging total patch changes 0 sec	3.7	5.9	8.3	-2.9	-2.2	2.1
Patch foraging total patch changes 12 sec	0.3	0.3	0.8	-0.9	-0.4	0.2
Patch foraging total patch changes 18 sec	0.6	0.7	2.0	-1.4	-0.3	0.3
Patch foraging total patch changes 24 sec	0.2	0.2	0.7	-0.8	0.1	0.2
Patch foraging total patch changes 6 sec	1.7	2.5	4.3	-1.2	-2.1	1.3
Patch foraging time to switch 0 sec	2.6	4.0	7.5	2.7	1.8	-1.1
Patch foraging water rate 0 sec	2.5	4.0	6.7	-2.6	-1.8	1.4
Patch foraging water rate 12 sec	1.9	2.9	5.1	-2.3	-1.3	1.4
Patch foraging water rate 18 sec	0.3	0.4	1.2	-1.1	-0.2	0.1
Patch foraging water rate 24 sec	0.8	1.1	1.9	-1.4	-1.0	0.6
Patch foraging water rate 6 sec	0.7	1.1	1.3	-1.1	-1.1	0.8
Seeking ratio, delayed vs. immediate footshock	2.0	2.4	3.3	1.6	1.1	-1.8
Distance traveled before self-admin	0.3	0.3	0.5	0.7	0.4	-0.5
Distance traveled after self-admin	0.3	0.3	0.7	0.8	0.2	0.4
Extensor digitorum longus weight	0.5	2.0	4.1	1.1	0.9	-2.0
Bone: elastic displacement	1.2	1.3	2.2	1.5	0.1	-1.3
Bone: elastic work	1.1	1.4	2.3	1.5	-0.1	-1.4
Bone: endosteal estimation	0.2	0.4	1.1	-1.0	0.2	-0.3
Bone: endosteal perimeter	0.5	1.1	3.1	-1.8	-0.3	0.1
Epididymis fat weight	1.5	3.4	4.1	1.7	2.0	-1.8
Delta time in closed arm before/after self-admin	2.3	2.2	3.7	1.0	1.4	-1.9
Delta time in open arm before/after self-admin	1.3	1.3	2.4	-1.5	-0.9	0.8
Diff in mean of infusions in LGA sessions	2.7	3.0	4.9	2.2	1.4	-1.4
Delay discount exponential model param	0.1	0.1	0.1	0.3	0.3	0.3
Extinction: sum of active levers before priming	0.3	0.3	0.5	0.2	0.7	-0.7
Active lever presses in extinction session 6	5.5	5.3	7.7	-2.3	-1.7	2.8
Bone: final force	0.5	0.8	2.1	0.0	-1.4	-0.5
Bone: final moment	0.4	0.6	1.8	-0.2	-1.3	-0.4
Food consumed during 24 hour testing period	3.3	3.9	6.5	-2.5	-0.3	2.3
Glucose	0.1	0.1	0.3	-0.5	-0.1	-0.3
Heart weight	0.6	0.9	1.3	-1.1	-1.1	0.3
Delay discount hyperbolic model param	0.1	0.2	0.3	0.6	0.3	0.2
Intermittent access intake day 1-15 change	2.4	2.3	3.0	-1.7	-1.6	1.3
Intermittent access intake escalation	2.9	2.8	3.9	-2.0	-1.6	1.4
Intermittent access intake escalation 2	0.6	0.6	0.9	-0.9	-0.6	0.8
Intermitt. access day 1 inactive lever presses	0.4	0.5	0.7	0.8	0.8	-0.3
Intermitt. access day 15 inactive lever presses	0.0	0.0	0.0	0.1	0.1	0.0
Intermitt. access escalation Index	0.1	0.1	0.1	0.0	-0.2	0.4
Intermittent access day 1 total infusions	0.2	0.3	0.6	-0.8	-0.2	-0.3
Intermittent access day 15 total infusions	1.9	2.1	3.7	-1.9	-1.4	0.8
Intermittent access terminal intake (last 3 days)	0.9	1.0	1.9	-1.4	-1.0	0.4
Intermittent access total infusions	0.3	0.3	0.8	-0.9	-0.4	-0.1
Intermittent access day 1 locomotion	0.0	0.0	0.1	-0.1	-0.3	-0.1
Intermittent access day 15 total locomotion	1.3	1.4	2.5	-1.6	-0.9	1.0
Intermittent access total locomotion	0.3	0.3	0.8	-0.9	-0.4	0.3
Intermittent access standard deviation	0.0	0.0	0.1	-0.3	0.1	-0.0
Left kidney weight	0.3	0.8	1.5	-0.9	1.2	0.3
Right kidney weight	0.3	0.7	1.3	-0.8	1.2	0.5
Cocaine induced anxiety	1.6	1.8	3.3	1.8	1.2	-0.9
Post-drug Anxiety	0.4	0.4	0.6	0.8	0.6	-0.5
Baseline Anxiety	1.7	1.8	3.5	-1.9	-1.1	0.8
Tail length	0.6	1.7	4.3	-0.9	2.1	0.2
Length with tail	0.3	1.1	3.2	-0.3	1.8	0.1
Length without tail	0.0	0.1	0.1	0.3	-0.3	-0.0
Times rat made contact with spout	1.0	1.1	2.9	0.6	1.7	-0.2
Lifetime Intake	0.5	0.5	1.2	-1.1	-0.6	0.1
Liver weight, left	0.4	0.6	0.7	0.7	0.9	-0.7
Liver weight, right	1.6	2.7	3.9	1.9	2.0	-0.8
Locomotor activity	1.5	2.3	4.7	-1.5	0.5	2.2
Locomotor testing distance	1.2	2.0	3.5	-1.9	0.1	1.6
Locomotor testing rearing	0.4	0.5	0.8	-0.7	0.9	0.6
Locomotion in novel chamber	1.3	1.6	1.9	-1.4	-1.3	1.1
Locomotion in novel chamber post-restriction	4.2	5.1	7.0	-2.6	-2.3	1.8
Fecal boli incidents, locomotor time 1	0.7	0.8	1.2	-1.1	-1.0	0.2
Change in fecal boli incidents, locomotor task	0.4	0.4	0.8	0.9	0.6	0.1
Time >=10cm from walls, locomotor time 1	2.2	2.2	2.5	-1.6	-1.5	1.3
Bouts of movement, locomotor time 1	0.1	0.1	0.3	-0.5	-0.3	-0.0
Total resting periods, locomotor time 1	0.1	0.1	0.2	-0.4	-0.4	-0.1
Rest time, locomotor task time 1	0.0	0.0	0.0	-0.2	-0.1	-0.1
Distance moved, locomotor task time 1	0.1	0.2	0.3	0.0	0.4	-0.5
Vertical activity count, locomotor time 1	0.0	0.0	0.1	-0.2	-0.3	-0.2
Time >=10cm from walls, locomotor time 2	0.6	0.7	1.5	-1.2	-0.5	0.6
Bouts of movement, locomotor time 2	0.6	0.6	1.1	-1.0	-0.0	0.9
Total resting periods, locomotor time 2	0.3	0.4	0.6	-0.8	0.0	0.7
Rest time, locomotor task time 2	1.0	1.1	2.5	1.6	0.5	-0.7
Distance moved, locomotor task time 2	0.8	1.0	2.7	-1.6	-0.3	0.5
Vertical activity count, locomotor time 2	0.2	0.2	0.6	-0.8	-0.1	-0.3
Light reinforcement 1	1.0	1.8	4.1	2.0	0.8	-0.7
Light reinforcement 2	0.5	0.7	1.5	-0.1	-0.8	1.2
Bone: marrow area	0.2	0.3	0.8	-0.9	0.2	-0.4
Bone: maximum diameter	0.8	1.4	2.3	-1.5	-1.4	0.1
Bone: maximum force	0.5	0.9	2.5	-0.2	-1.6	-0.5
Bone: maximum moment	0.5	0.8	2.1	-0.4	-1.4	-0.3
Mean time between licks in bursts	1.8	2.5	5.8	-2.4	0.3	1.3
Mean num. licks in bursts	2.3	2.7	5.5	-2.3	-0.8	1.4
Cd content in liver	1.6	1.8	2.2	1.5	1.0	-1.5
Co content in liver	0.6	0.8	1.2	-0.5	1.1	-0.9
Cu content in liver	0.4	0.5	0.9	-0.8	0.9	0.1
Fe content in liver	0.3	0.4	1.1	0.2	-0.1	-1.1
K content in liver	0.4	0.4	1.0	0.4	1.0	0.2
Mg content in liver	0.2	0.2	0.2	-0.5	0.0	0.5
Mn content in liver	0.3	0.3	0.9	0.9	0.0	-0.0
Na content in liver	1.8	1.9	3.7	-1.1	-0.9	1.9
Rb content in liver	0.2	0.2	0.7	-0.8	0.0	-0.2
Se content in liver	2.1	2.5	4.8	2.2	1.4	-0.9
Sr content in liver	0.1	0.1	0.2	-0.1	-0.1	-0.5
Zn content in liver	3.3	3.7	6.1	-2.5	-1.4	1.7
Bone: minimum diameter	0.4	0.7	1.2	0.2	0.8	-1.1
Time in familiar zone, hab. session 1	0.2	0.2	0.3	0.4	0.4	-0.5
Time in novel zone, hab. session 1	0.1	0.1	0.1	0.4	0.2	-0.3
Total zone transitions, hab. session 1	1.2	1.7	2.4	-0.6	-1.5	1.5
Total locomotion distance, hab. session 1	1.0	1.4	2.3	1.5	1.3	0.2
Locomotion velocity, hab. session 1	0.6	0.8	1.4	1.2	0.9	0.5
Time in familiar zone, hab. session 2	0.2	0.2	0.5	-0.7	0.2	-0.1
Time in novel zone, hab. session 2	0.0	0.0	0.0	0.1	-0.2	-0.1
Total zone transitions, hab. session 2	3.2	4.1	5.7	-1.4	-2.4	2.2
Total locomotion distance, hab. session 2	0.3	0.4	0.8	0.9	0.4	0.6
Locomotion velocity, hab. session 2	0.4	0.5	0.9	0.9	0.6	0.6
Novel to familiar place preference ratio	0.6	0.6	0.9	-0.5	-0.9	0.9
Novelty place preference	0.3	0.3	0.4	-0.4	-0.5	0.6
Time in novel zone, NPP test	0.4	0.4	0.4	-0.6	-0.7	0.6
Total zone transitions, NPP test	0.6	0.9	1.9	-0.6	-1.4	0.6
Total locomotion distance, NPP test	0.8	1.1	2.2	1.5	0.9	-0.4
Locomotion velocity, NPP test	1.0	1.5	3.0	1.7	1.1	-0.4
Intraocular pressure	0.7	1.0	1.5	-0.8	-1.2	-1.0
Delta distance traveled before/after self-admin	0.6	0.7	1.7	-0.3	-0.4	1.3
Delta ambulatory time before/after self-admin	0.8	0.8	1.7	-0.4	-0.8	1.3
Parametrial fat weight	0.2	0.4	1.1	1.1	0.2	-0.3
Pavlov. Cond. lever latency	0.4	0.5	1.4	1.2	-0.3	-0.1
Pavlov. Cond. magazine entry latency	0.9	1.1	2.3	-1.5	-0.8	0.6
Pavlov. Cond. change in total contacts	0.2	0.3	0.8	-0.9	-0.1	-0.2
Pavlov. Cond. index score	0.6	0.8	2.3	-1.5	0.2	0.2
Pavlov. Cond. latency score	0.6	0.8	2.3	-1.5	-0.0	0.3
Pavlov. Cond. lever contacts	0.5	0.6	0.9	-0.9	1.0	-0.3
Pavlov. Cond. magazine entry number	1.0	1.3	2.9	1.7	0.8	-0.6
Pavlov. Cond. intertrial magazine entries	1.4	1.7	2.9	1.4	1.7	-0.6
Pavlov. Cond. lever-magazine prob. diff.	0.5	0.6	1.8	-1.3	0.3	0.1
Pavlov. Cond. response bias	0.3	0.3	0.5	-0.7	0.7	-0.1
Pavlov. Cond. lever latency	14.3	19.3	31.1	5.6	4.2	-3.0
Pavlov. Cond. magazine entry latency	5.1	5.9	9.8	-2.6	-3.1	1.1
Pavlov. Cond. change in total contacts	10.5	14.5	21.6	-4.7	-3.8	2.8
Pavlov. Cond. index score	11.4	14.7	22.5	-4.7	-4.0	2.4
Pavlov. Cond. latency score	11.1	13.8	20.3	-4.5	-4.0	2.3
Pavlov. Cond. lever contacts	15.3	20.9	32.9	-5.7	-4.4	3.3
Pavlov. Cond. magazine entry number	5.3	6.5	10.1	3.2	3.0	-0.5
Pavlov. Cond. intertrial magazine entries	0.8	1.0	2.8	0.3	1.7	0.5
Pavlov. Cond. lever-magazine prob. diff.	10.6	13.5	20.8	-4.6	-3.8	2.3
Pavlov. Cond. response bias	14.7	20.0	31.9	-5.6	-4.4	3.0
Time in closed arm before self-admin	2.0	2.2	3.1	-1.3	-1.4	1.7
Time in closed arm after self-admin	0.1	0.1	0.3	0.2	-0.2	-0.5
Time in open arm before self-admin	2.4	2.6	4.0	2.0	1.4	-1.4
Time in open arm after self-admin	0.0	0.0	0.1	-0.0	0.3	-0.1
Bone: periosteal estimation	0.3	0.5	0.8	-0.9	-0.4	-0.8
Bone: periosteal perimeter	0.4	0.6	1.7	-1.3	-0.3	0.2
Bone: post-yield work	0.5	0.6	0.9	-0.7	-1.0	0.7
Progressive ratio test 1 active lever presses	0.1	0.1	0.1	0.4	0.0	-0.2
Progressive ratio test 1 breakpoint	0.1	0.1	0.2	0.4	0.0	-0.1
Progressive ratio test 1 inactive lever presses	0.0	0.0	0.0	-0.1	-0.0	0.0
Progressive ratio test 2 active lever presses	0.5	0.6	1.6	-1.3	-0.3	-0.1
Progressive ratio test 2 breakpoint	0.4	0.5	1.3	-1.2	-0.3	-0.0
Progressive ratio test 2 inactive lever presses	0.2	0.2	0.7	-0.8	-0.1	-0.1
Incentive Sensitization - Responses	1.0	1.0	2.7	-1.6	-0.5	0.2
Incentive Sensitization - Breakpoint	1.0	1.0	2.7	-1.7	-0.6	0.3
Sum of active levers in priming session hrs 5-6	0.1	0.1	0.2	-0.1	0.4	0.5
Progressive ratio	0.3	0.4	0.8	-0.2	-0.9	-0.4
Food seeking constrained by brief footshock	1.5	1.8	2.8	-1.6	-0.3	1.7
Seeking ratio, punishment vs. effort	0.9	1.1	2.1	-0.9	0.5	1.5
Retroperitoneal fat weight	4.9	16.1	18.2	4.1	4.3	-3.7
Reaction time number correct	1.1	1.6	3.9	-0.5	-0.8	2.0
Reaction time mean minus median	0.7	0.9	1.6	-1.3	-0.5	0.9
Reaction time mean minus median AUC	1.6	2.0	2.5	-1.6	-1.1	1.5
Reaction time num false alarms	2.7	3.7	5.4	2.3	1.2	-2.1
Reaction time num false alarms AUC	1.6	2.3	3.0	1.7	1.0	-1.7
Reaction time trials correct on left	1.1	1.6	3.9	-0.5	-0.8	2.0
Reaction time trials on left	1.2	1.7	4.0	-0.5	-0.8	2.0
Reaction time mean	0.0	0.1	0.1	0.3	0.1	-0.3
Reaction time mean AUC	0.1	0.2	0.3	0.5	0.2	-0.5
Median of all reaction times	0.2	0.3	0.5	0.7	0.2	-0.6
Reaction time omissions	0.1	0.1	0.3	0.2	-0.2	-0.5
Reaction time false alarm rate	2.8	3.9	6.7	1.9	1.0	-2.6
Reaction time premature initiation rate	0.1	0.1	0.3	-0.5	0.3	0.2
Reaction time premature initiations	0.5	0.7	1.4	-0.8	-0.3	1.2
Std. dev. reaction times	0.1	0.1	0.3	-0.5	0.1	0.0
Reaction time trials completed	1.2	1.7	4.0	-0.5	-0.8	2.0
Reaction time trials AUC	1.1	1.6	3.8	-0.5	-0.8	2.0
Run reversals in cocaine runway, females	3.4	3.3	5.0	1.2	1.9	-2.2
Run reversals in cocaine runway, males	0.3	0.3	0.6	-0.3	-0.5	-0.8
Latency to leave start box in cocaine runway	1.0	1.1	2.1	1.4	1.1	-0.4
Latency to leave start box in cocaine runway, F	1.2	1.3	2.0	1.4	1.2	-0.8
Latency to leave start box in cocaine runway, M	0.2	0.2	0.3	0.3	-0.3	0.6
Std. dev. time between licks in bursts	0.8	0.9	1.2	-0.8	1.1	1.0
Total sessions with >9 infusions	1.9	2.1	2.8	-1.7	-1.5	1.2
Short access day 1 total inactive lever presses	0.2	0.2	0.4	-0.0	0.6	-0.5
Short access day 10 total inactive lever presses	0.2	0.2	0.4	0.4	0.2	0.6
Short access day 1 total infusions	1.6	1.7	3.2	-1.8	-0.9	1.0
Short access day 10 total infusions	0.2	0.2	0.5	-0.7	-0.3	-0.4
Short access total infusions	0.2	0.2	0.6	-0.7	-0.4	0.1
Short access day 1 locomotion	3.0	3.2	3.9	-1.9	-2.0	1.5
Short access day 10 total locomotion	0.2	0.2	0.3	-0.5	-0.4	0.3
Short access total locomotion	0.4	0.4	0.6	-0.4	-0.6	0.8
One hour access (0.3 mA shock)	0.7	0.8	2.2	-1.5	-0.4	0.2
Compulsive drug intake	0.1	0.1	0.1	-0.1	-0.1	0.4
One hour access (shock baseline)	0.8	0.9	2.0	-1.4	-0.6	0.6
Social response proportion	0.5	0.5	0.9	0.7	0.9	0.5
Social responses	1.1	1.5	2.2	1.3	1.5	-0.7
Social time	1.2	1.5	3.6	1.9	0.9	-0.3
Soleus weight	0.7	2.1	3.2	1.0	1.8	-1.5
Bone: stiffness	0.4	0.7	1.6	0.3	-1.3	-0.5
Tibialis anterior weight	0.0	0.0	0.0	-0.0	-0.1	0.2
Time to tail flick, vehicle, before self-admin	0.6	0.7	1.0	1.0	0.4	-0.9
Time to tail flick, vehicle, after self-admin	1.5	1.6	2.3	-1.5	-1.4	0.8
Time to tail flick, test, before self-admin	0.3	0.3	0.8	-0.1	-0.2	-0.9
Time to tail flick, test, after self-admin	0.3	0.3	0.4	-0.4	0.5	-0.6
Delta time to tail flick, vehicle, before/after SA	3.4	3.4	4.6	-2.2	-1.8	1.5
Delta time to tail flick, test, before/after SA	0.1	0.1	0.3	0.0	0.4	0.5
Tibia length	1.4	4.0	4.9	-2.0	-2.2	1.7
Ambulatory time before self-admin	0.3	0.3	0.5	0.7	0.2	-0.7
Ambulatory time after self-admin	0.2	0.2	0.3	0.6	-0.1	0.5
Bone: tissue strength	1.0	1.0	2.0	0.3	-1.4	0.9
Total heroin consumption	0.1	0.2	0.4	-0.3	-0.6	0.2
Bone: trabecular number	0.9	1.4	2.5	1.6	0.1	-1.3
Bone: trabecular spacing	1.6	2.1	2.9	-1.7	-0.7	1.7
Bone: trabecular thickness	0.9	1.1	1.9	0.9	0.8	-1.4
Bone: trabecular tissue density	0.5	0.7	1.0	1.0	1.0	-0.1
Water consumed over 24 hours	1.0	1.2	2.0	1.2	1.4	-0.4
Number of responses in last shaping day	0.3	0.3	0.6	0.4	0.8	-0.5