Hub : Genes

Art2b

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Adipose gene expression Art2b 0.07 0.04 5.6e-06 0.04 0.03 0.03 0.04 1.9e-05 2.4e-04 1.6e-04 8.5e-05
2 Liver gene expression Art2b 0.04 0.03 3.3e-03 0.02 0.02 0.01 0.02 2.8e-03 2.5e-03 1.0e-02 3.2e-03
3 Liver alternative TSS NM_198735.3 0.04 0.03 2.4e-03 0.02 0.01 0.01 0.01 4.4e-03 8.6e-03 7.0e-02 2.0e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
Bone: apparent density0.40.71.40.6-0.61.2
Area under the delay curve0.10.20.40.6-0.3-0.1
BMI with tail0.10.40.90.4-0.9-0.1
BMI without tail0.21.22.1-1.50.9-0.8
Body weight0.62.75.3-1.11.3-2.3
Weight adjusted by age0.20.70.8-0.90.8-0.8
Bone surface0.40.91.4-1.01.2-0.3
Bone volume0.20.40.7-0.70.8-0.3
Breakpoint value in progressive ratio session0.40.81.11.0-1.00.6
Number of licking bursts1.13.35.22.3-2.00.8
Context. condit. distance diff. score2.22.74.9-2.21.7-0.6
Locomotion velocity, session 11.51.72.60.8-1.31.6
Locomotion distance, session 10.20.30.5-0.70.20.7
Locomotion velocity, session 20.10.10.1-0.2-0.20.4
Locomotion distance, session 20.10.10.2-0.40.00.3
Locomotion velocity, session 30.50.61.1-1.00.80.3
Locomotion distance, session 30.60.71.0-1.00.60.8
Stereotopy head waving bouts, day 30.20.30.70.30.2-0.8
Stereotopy head waving duration, day 30.10.10.2-0.40.30.1
Locomotion velocity, session 70.40.40.70.3-0.70.8
Locomotion distance, session 70.10.20.30.5-0.4-0.0
Stereotopy head waving bouts, day 72.42.74.8-2.21.8-0.1
Stereotopy head waving duration, day 72.12.64.6-2.21.8-0.2
Locomotion velocity, session 81.31.62.4-1.61.4-0.6
Locomotion distance, session 81.72.44.5-2.11.6-0.6
Degree of sensitization distance1.11.23.50.40.3-1.9
Degree of sensitization stereotypy4.55.08.7-3.02.5-0.5
Conditioned locomotion0.10.20.30.50.0-0.5
Cocaine response after cond. corrected0.81.22.11.4-1.20.2
Cocaine response after cond. not corrected0.71.01.31.0-1.20.7
Cocaine response before conditioning0.70.81.5-1.20.40.9
Saline control response2.83.95.1-2.02.3-1.7
Bone: connectivity density1.11.73.90.5-1.02.0
Bone: cortical apparent density0.81.22.41.6-1.1-0.3
Bone: cortical area0.30.60.9-0.50.7-0.9
Bone: cortical porosity0.00.00.1-0.10.20.3
Bone: cortical porosity0.10.10.1-0.30.30.3
Bone: cortical thickness0.50.81.11.0-1.10.5
Bone: cortical thickness0.10.10.2-0.20.3-0.5
Bone: cortical tissue density0.81.32.51.6-1.1-0.2
Condit. Reinf. active minus inactive responses1.51.62.6-0.91.2-1.6
Condit. Reinf. active-inactive response ratio2.12.32.8-1.11.6-1.7
Condit. Reinf. active responses0.50.61.5-0.10.6-1.2
Condit. Reinf. inactive responses0.30.40.70.8-0.60.2
Incentive salience index mean0.70.91.7-0.40.9-1.3
Condit. Reinf. lever presses0.00.00.00.10.1-0.1
Condit. Reinf. active minus inactive responses7.010.813.6-3.63.7-2.5
Condit. Reinf. active-inactive response ratio0.81.21.7-1.31.3-0.5
Condit. Reinf. active responses11.216.119.9-4.24.5-3.3
Condit. Reinf. inactive responses6.08.910.4-2.93.2-2.8
Condit. Reinf. lever presses13.519.625.8-5.14.9-3.0
Condit. Reinf. lever reinforcers received11.816.520.8-4.34.6-3.2
Conditioned reinforcement - actives0.00.10.1-0.40.20.3
Conditioned reinforcement - inactives0.20.41.01.0-0.50.0
Conditioned locomotion0.40.51.1-0.70.11.1
Patch foraging indifference point 0 sec0.72.03.1-1.81.6-0.7
Patch foraging indifference point AUC0.10.30.6-0.60.8-0.3
Delay disc. indifference point, 0s delay0.80.91.3-1.01.1-0.7
Delay disc. indifference point, 16s delay0.10.10.30.6-0.1-0.2
Delay disc. indifference point, 2s delay1.01.11.4-0.81.1-1.2
Delay disc. indifference point, 24s delay0.60.91.91.4-0.90.1
Delay disc. indifference point, 4s delay2.12.22.9-1.21.5-1.7
Delay disc. indifference point, 8s delay0.10.20.40.6-0.40.2
Indifference point function ln k0.00.10.1-0.40.10.2
Indifference point function log k0.00.10.1-0.40.10.2
Patch foraging total patch changes 0 sec0.61.62.6-1.61.4-0.6
Patch foraging total patch changes 12 sec1.21.72.0-1.11.4-1.4
Patch foraging total patch changes 18 sec0.51.21.7-1.31.3-0.5
Patch foraging total patch changes 24 sec0.51.82.0-1.21.4-1.4
Patch foraging total patch changes 6 sec0.30.40.7-0.80.70.1
Patch foraging time to switch 0 sec1.14.26.42.5-2.21.1
Patch foraging water rate 0 sec0.83.15.0-2.21.9-0.9
Patch foraging water rate 12 sec0.20.71.8-1.30.6-0.1
Patch foraging water rate 18 sec1.43.14.5-2.11.6-1.5
Patch foraging water rate 24 sec0.00.10.1-0.4-0.10.1
Patch foraging water rate 6 sec0.10.20.5-0.70.3-0.2
Seeking ratio, delayed vs. immediate footshock2.02.93.51.8-1.91.4
Distance traveled before self-admin0.20.40.70.6-0.80.3
Distance traveled after self-admin0.50.91.60.4-1.01.3
Extensor digitorum longus weight0.00.20.20.5-0.4-0.4
Bone: elastic displacement2.73.43.91.7-2.01.9
Bone: elastic work4.86.37.82.1-2.62.8
Bone: endosteal estimation1.74.25.1-1.92.3-1.9
Bone: endosteal perimeter1.94.65.9-2.22.4-1.8
Epididymis fat weight0.20.91.41.2-1.10.3
Delta time in closed arm before/after self-admin0.70.71.11.1-0.7-0.6
Delta time in open arm before/after self-admin2.73.24.4-2.02.1-1.1
Diff in mean of infusions in LGA sessions0.71.32.91.7-1.00.4
Delay discount exponential model param0.20.20.5-0.70.40.0
Extinction: sum of active levers before priming0.20.30.5-0.30.4-0.7
Active lever presses in extinction session 60.50.51.1-0.5-0.01.1
Bone: final force0.10.20.40.50.0-0.6
Bone: final moment0.10.20.40.30.2-0.7
Food consumed during 24 hour testing period1.02.03.9-2.01.40.2
Glucose0.00.10.1-0.0-0.30.4
Heart weight0.71.11.8-1.31.3-0.1
Delay discount hyperbolic model param0.10.10.3-0.50.20.2
Intermittent access intake day 1-15 change0.10.40.9-0.2-0.40.9
Intermittent access intake escalation0.10.51.2-0.6-0.11.1
Intermittent access intake escalation 20.10.10.2-0.2-0.10.4
Intermitt. access day 1 inactive lever presses0.11.83.71.9-1.2-0.1
Intermitt. access day 15 inactive lever presses0.10.60.70.8-0.70.8
Intermitt. access escalation Index0.00.00.0-0.10.2-0.2
Intermittent access day 1 total infusions0.41.21.8-1.31.3-0.4
Intermittent access day 15 total infusions0.30.61.2-1.10.90.1
Intermittent access terminal intake (last 3 days)0.61.01.7-1.31.2-0.3
Intermittent access total infusions1.01.21.8-1.31.2-0.5
Intermittent access day 1 locomotion0.10.10.2-0.20.40.4
Intermittent access day 15 total locomotion0.20.72.0-0.1-0.21.4
Intermittent access total locomotion0.30.40.6-0.80.70.3
Intermittent access standard deviation0.00.10.20.1-0.2-0.4
Left kidney weight0.11.02.0-0.70.7-1.4
Right kidney weight0.42.54.6-1.11.3-2.1
Cocaine induced anxiety1.02.74.92.2-1.70.8
Post-drug Anxiety0.50.61.51.2-0.6-0.1
Baseline Anxiety1.72.93.6-1.81.9-1.4
Tail length2.211.914.9-3.13.9-3.3
Length with tail2.410.812.7-2.73.5-3.6
Length without tail0.10.51.1-0.10.6-1.0
Times rat made contact with spout0.10.20.30.4-0.0-0.5
Lifetime Intake1.31.62.5-1.61.4-0.5
Liver weight, left0.30.51.40.40.1-1.2
Liver weight, right0.40.71.90.30.3-1.4
Locomotor activity0.30.50.8-0.90.7-0.5
Locomotor testing distance1.12.73.1-1.81.7-1.5
Locomotor testing rearing0.72.63.8-1.31.5-1.9
Locomotion in novel chamber1.41.92.61.0-1.41.6
Locomotion in novel chamber post-restriction0.20.50.8-0.90.60.6
Fecal boli incidents, locomotor time 10.82.12.41.5-1.31.5
Change in fecal boli incidents, locomotor task0.40.50.8-0.60.5-0.9
Time >=10cm from walls, locomotor time 10.50.61.0-1.00.9-0.2
Bouts of movement, locomotor time 10.10.10.2-0.20.50.0
Total resting periods, locomotor time 10.10.20.40.2-0.10.6
Rest time, locomotor task time 10.10.10.3-0.00.00.5
Distance moved, locomotor task time 10.10.20.60.00.0-0.8
Vertical activity count, locomotor time 10.10.41.20.00.3-1.1
Time >=10cm from walls, locomotor time 21.74.85.6-2.12.4-2.1
Bouts of movement, locomotor time 20.51.52.4-0.71.3-1.5
Total resting periods, locomotor time 20.20.61.2-0.20.8-1.1
Rest time, locomotor task time 21.42.42.81.7-1.71.3
Distance moved, locomotor task time 22.43.23.4-1.81.8-1.7
Vertical activity count, locomotor time 20.61.42.3-0.81.1-1.5
Light reinforcement 10.83.75.02.0-2.21.5
Light reinforcement 20.92.14.10.4-1.42.0
Bone: marrow area1.53.64.3-1.72.1-1.8
Bone: maximum diameter2.24.45.2-2.12.3-1.8
Bone: maximum force0.00.00.10.30.0-0.3
Bone: maximum moment0.00.00.10.00.2-0.2
Mean time between licks in bursts1.710.411.8-2.73.4-3.4
Mean num. licks in bursts1.13.14.5-2.12.0-1.0
Cd content in liver0.10.10.20.20.2-0.5
Co content in liver2.83.33.8-1.61.9-1.9
Cu content in liver1.51.82.5-1.01.4-1.6
Fe content in liver0.00.00.00.2-0.10.0
K content in liver0.30.20.40.6-0.3-0.6
Mg content in liver0.00.00.0-0.0-0.10.0
Mn content in liver2.42.73.21.5-1.81.7
Na content in liver0.40.40.9-0.90.70.1
Rb content in liver0.20.20.4-0.30.6-0.3
Se content in liver5.16.17.72.8-2.61.9
Sr content in liver0.60.51.3-0.4-0.31.1
Zn content in liver1.82.13.0-1.71.5-1.0
Bone: minimum diameter1.73.35.2-1.21.8-2.3
Time in familiar zone, hab. session 10.20.30.3-0.60.5-0.5
Time in novel zone, hab. session 10.10.10.30.6-0.3-0.1
Total zone transitions, hab. session 10.20.30.7-0.40.10.8
Total locomotion distance, hab. session 10.81.13.00.10.4-1.7
Locomotion velocity, hab. session 10.50.72.10.10.3-1.4
Time in familiar zone, hab. session 23.43.84.2-2.02.0-1.8
Time in novel zone, hab. session 22.32.63.01.4-1.71.6
Total zone transitions, hab. session 21.31.73.4-1.81.30.0
Total locomotion distance, hab. session 22.33.06.0-1.01.4-2.5
Locomotion velocity, hab. session 22.23.06.2-0.91.4-2.5
Novel to familiar place preference ratio0.70.91.7-0.20.9-1.3
Novelty place preference0.70.91.7-0.31.0-1.3
Time in novel zone, NPP test1.01.22.1-0.51.2-1.4
Total zone transitions, NPP test0.40.61.5-0.0-0.51.2
Total locomotion distance, NPP test0.20.30.60.5-0.4-0.8
Locomotion velocity, NPP test0.30.50.60.8-0.8-0.5
Intraocular pressure0.81.33.00.3-0.81.7
Delta distance traveled before/after self-admin0.91.01.6-1.31.1-0.1
Delta ambulatory time before/after self-admin0.40.71.2-1.10.90.2
Parametrial fat weight0.92.22.91.1-1.71.6
Pavlov. Cond. lever latency0.70.91.41.0-1.20.6
Pavlov. Cond. magazine entry latency3.14.05.5-2.32.1-1.3
Pavlov. Cond. change in total contacts1.61.72.5-1.31.6-1.0
Pavlov. Cond. index score2.12.73.6-1.91.9-1.0
Pavlov. Cond. latency score1.92.53.3-1.71.8-1.0
Pavlov. Cond. lever contacts0.91.01.4-1.21.2-0.6
Pavlov. Cond. magazine entry number2.93.64.92.2-2.11.2
Pavlov. Cond. intertrial magazine entries0.60.71.21.1-0.80.3
Pavlov. Cond. lever-magazine prob. diff.1.82.23.0-1.71.7-0.8
Pavlov. Cond. response bias1.31.62.4-1.51.4-0.7
Pavlov. Cond. lever latency14.220.029.35.4-4.82.7
Pavlov. Cond. magazine entry latency1.62.24.6-2.21.4-0.3
Pavlov. Cond. change in total contacts7.217.526.1-5.14.5-2.5
Pavlov. Cond. index score8.413.320.2-4.53.9-2.1
Pavlov. Cond. latency score6.810.917.4-4.23.5-1.7
Pavlov. Cond. lever contacts13.019.227.1-5.24.8-2.8
Pavlov. Cond. magazine entry number3.95.19.53.1-2.30.6
Pavlov. Cond. intertrial magazine entries0.71.42.4-0.61.2-1.6
Pavlov. Cond. lever-magazine prob. diff.8.513.119.6-4.43.9-2.1
Pavlov. Cond. response bias13.118.227.3-5.24.6-2.4
Time in closed arm before self-admin0.91.63.0-1.71.3-0.3
Time in closed arm after self-admin0.50.50.70.8-0.80.5
Time in open arm before self-admin5.46.68.22.8-2.91.9
Time in open arm after self-admin0.10.10.2-0.30.4-0.3
Bone: periosteal estimation1.02.42.8-1.41.7-1.5
Bone: periosteal perimeter1.12.22.7-1.61.6-1.3
Bone: post-yield work0.20.30.3-0.50.5-0.5
Progressive ratio test 1 active lever presses0.10.10.4-0.10.00.7
Progressive ratio test 1 breakpoint0.10.10.4-0.10.10.6
Progressive ratio test 1 inactive lever presses0.10.30.50.7-0.50.4
Progressive ratio test 2 active lever presses0.10.20.4-0.50.6-0.1
Progressive ratio test 2 breakpoint0.20.20.4-0.60.6-0.1
Progressive ratio test 2 inactive lever presses0.00.00.0-0.10.00.2
Incentive Sensitization - Responses0.20.60.7-0.70.8-0.6
Incentive Sensitization - Breakpoint0.20.40.5-0.70.7-0.4
Sum of active levers in priming session hrs 5-60.10.10.1-0.40.2-0.2
Progressive ratio0.10.30.8-0.4-0.10.9
Food seeking constrained by brief footshock2.02.63.1-1.71.8-1.3
Seeking ratio, punishment vs. effort1.22.74.6-1.11.5-2.1
Retroperitoneal fat weight0.52.44.02.0-1.4-1.0
Reaction time number correct0.10.20.60.1-0.30.8
Reaction time mean minus median0.10.91.2-0.71.0-1.1
Reaction time mean minus median AUC0.10.81.0-0.70.9-1.0
Reaction time num false alarms0.91.53.11.7-1.2-0.2
Reaction time num false alarms AUC0.61.52.81.7-1.3-0.0
Reaction time trials correct on left0.10.20.60.1-0.30.8
Reaction time trials on left0.10.30.60.2-0.40.8
Reaction time mean0.51.11.61.3-0.6-1.2
Reaction time mean AUC0.51.12.01.4-0.7-0.9
Median of all reaction times1.01.63.01.7-1.0-0.9
Reaction time omissions0.20.40.70.8-0.4-0.5
Reaction time false alarm rate1.01.32.51.6-1.2-0.3
Reaction time premature initiation rate2.13.33.7-1.81.9-1.8
Reaction time premature initiations0.51.51.8-1.31.3-0.9
Std. dev. reaction times0.51.53.9-0.10.8-2.0
Reaction time trials completed0.10.30.60.2-0.40.8
Reaction time trials AUC0.00.10.30.1-0.20.5
Run reversals in cocaine runway, females1.21.32.8-0.70.9-1.7
Run reversals in cocaine runway, males0.50.50.60.8-0.70.7
Latency to leave start box in cocaine runway0.81.01.71.3-1.00.7
Latency to leave start box in cocaine runway, F0.40.51.11.1-0.4-0.4
Latency to leave start box in cocaine runway, M1.71.62.90.8-1.11.7
Std. dev. time between licks in bursts1.93.55.2-1.31.9-2.3
Total sessions with >9 infusions1.92.43.7-1.91.7-0.7
Short access day 1 total inactive lever presses0.00.00.10.20.3-0.0
Short access day 10 total inactive lever presses0.21.52.81.7-1.20.4
Short access day 1 total infusions2.14.25.2-2.22.3-1.6
Short access day 10 total infusions1.11.82.7-1.61.5-0.7
Short access total infusions1.72.43.8-1.91.8-0.6
Short access day 1 locomotion0.30.50.8-0.90.50.6
Short access day 10 total locomotion0.10.30.5-0.70.7-0.1
Short access total locomotion0.10.20.5-0.30.10.7
One hour access (0.3 mA shock)0.20.20.5-0.70.50.0
Compulsive drug intake2.13.13.61.5-1.81.9
One hour access (shock baseline)0.61.62.5-1.61.3-0.8
Social response proportion0.30.40.70.8-0.70.1
Social responses0.30.40.80.50.1-0.9
Social time1.72.62.91.7-1.61.5
Soleus weight0.10.30.60.60.0-0.8
Bone: stiffness0.20.40.70.70.0-0.8
Tibialis anterior weight0.20.71.6-0.30.7-1.2
Time to tail flick, vehicle, before self-admin0.30.30.7-0.80.60.0
Time to tail flick, vehicle, after self-admin0.40.81.3-1.11.2-0.1
Time to tail flick, test, before self-admin2.73.14.0-1.92.0-1.3
Time to tail flick, test, after self-admin2.52.63.2-1.31.7-1.8
Delta time to tail flick, vehicle, before/after SA0.00.00.00.10.10.2
Delta time to tail flick, test, before/after SA0.60.81.21.1-1.00.3
Tibia length0.41.21.7-1.31.3-0.6
Ambulatory time before self-admin0.20.60.90.7-1.00.6
Ambulatory time after self-admin0.30.41.1-0.3-0.31.0
Bone: tissue strength2.22.33.70.9-1.51.9
Total heroin consumption0.20.20.3-0.50.3-0.6
Bone: trabecular number1.42.73.71.4-1.61.9
Bone: trabecular spacing0.20.20.5-0.70.20.3
Bone: trabecular thickness0.30.41.00.20.5-1.0
Bone: trabecular tissue density0.81.53.31.00.1-1.8
Water consumed over 24 hours0.20.30.40.6-0.60.5
Number of responses in last shaping day0.20.30.60.8-0.1-0.4