Hub : Traits

Vertical activity count, locomotor time 2

Number of times vertical sensor beam was broken with each rearing bout separated by a period of not rearing (vertical sensor not activated) lasting 1s or longer in time2

Tags: Behavior · Locomotion

Project: u01_suzanne_mitchell

1 significantly associated model · 1 unique gene

Significant Loci

# chr p0 p1 # assoc genes # joint models best TWAS P best SNP P cond SNP P % var exp joint genes
1 1 29741220 30154169 1 1 3.4e-07 0.011 0.096 58 Slc12a7

p0: physical position of the start of the locus. p1: physical position of the end of the locus. # joint models: number of models selected by step-wise conditional analysis.

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Light reinforcement 1 2.6 1 0 0 0 1 Slc12a7
Reaction time mean minus median 6.4 1 0 0 0 1 Slc12a7
Reaction time mean minus median AUC 6.8 1 0 0 0 1 Slc12a7
Std. dev. reaction times 5.8 1 0 0 0 1 Slc12a7
Social response proportion 3.9 1 0 0 0 1 Slc12a7
Conditioned reinforcement - actives 5.1 1 0 0 0 1 Slc12a7
Conditioned locomotion 3.6 1 0 0 0 1 Slc12a7
Intermittent access day 1 total infusions 4.5 1 0 0 0 1 Slc12a7
Intermittent access terminal intake (last 3 days) 3.8 1 0 0 0 1 Slc12a7
Intermittent access total infusions 4.5 1 0 0 0 1 Slc12a7
Intermittent access day 15 total locomotion 4.7 1 0 0 0 1 Slc12a7
Lifetime Intake 5.7 1 0 0 0 1 Slc12a7
Progressive ratio test 1 active lever presses 8.5 1 0 0 0 1 Slc12a7
Progressive ratio test 1 breakpoint 9.6 1 0 0 0 1 Slc12a7
Total sessions with >9 infusions 4.2 1 0 0 0 1 Slc12a7
Short access day 10 total infusions 5.9 1 0 0 0 1 Slc12a7
Short access total infusions 6.1 1 0 0 0 1 Slc12a7
Total zone transitions, hab. session 2 3.7 1 0 0 0 1 Slc12a7
Distance traveled after self-admin 7.3 1 0 0 0 1 Slc12a7
Extinction: sum of active levers before priming 8.2 1 0 0 0 1 Slc12a7
Delta distance traveled before/after self-admin 5.0 1 0 0 0 1 Slc12a7
Delta ambulatory time before/after self-admin 5.8 1 0 0 0 1 Slc12a7
Delta time to tail flick, vehicle, before/after SA 4.8 1 0 0 0 1 Slc12a7
Ambulatory time after self-admin 6.4 1 0 0 0 1 Slc12a7
Delay disc. indifference point, 0s delay 4.1 1 0 0 0 1 Slc12a7
Delay disc. indifference point, 8s delay 6.0 1 0 0 0 1 Slc12a7
Time >=10cm from walls, locomotor time 1 15.4 1 0 0 0 1 Slc12a7
Rest time, locomotor task time 1 13.4 1 0 0 0 1 Slc12a7
Distance moved, locomotor task time 1 3.5 1 0 0 0 1 Slc12a7
Vertical activity count, locomotor time 1 7.9 1 0 0 0 1 Slc12a7
Time >=10cm from walls, locomotor time 2 11.5 1 0 0 0 1 Slc12a7
Bouts of movement, locomotor time 2 3.9 1 0 0 0 1 Slc12a7
Total resting periods, locomotor time 2 4.1 1 0 0 0 1 Slc12a7
Rest time, locomotor task time 2 14.0 1 0 0 0 1 Slc12a7
Distance moved, locomotor task time 2 3.9 1 0 0 0 1 Slc12a7
Locomotion in novel chamber post-restriction 7.1 1 0 0 0 1 Slc12a7
Run reversals in cocaine runway, females 4.1 1 0 0 0 1 Slc12a7

chisq ratio: Average Chi2 statistic for the selected genes in the secondary trait, divided by the average statistic for all genes in the secondary trait. # genes+: Shared significant genes at Bonferroni correction. # genes++: Shared significant genes at transcriptome-wide significance. % genes++: Number of [++] genes as a percentage of primary trait’s total joint genes. corr: Correlation of effect sizes across the [+] genes.

Associations by panel

tissue modality # hits % hits/tests avg chisq
Adipose alternative polyA 0 0.000 0.99
Adipose alternative TSS 0 0.000 1.10
Adipose gene expression 0 0.000 1.07
Adipose isoform ratio 0 0.000 1.10
Adipose intron excision ratio 0 0.000 1.19
Adipose mRNA stability 0 0.000 1.06
BLA alternative polyA 0 0.000 1.16
BLA alternative TSS 0 0.000 1.21
BLA gene expression 0 0.000 1.11
BLA isoform ratio 0 0.000 1.09
BLA intron excision ratio 0 0.000 1.15
BLA mRNA stability 0 0.000 1.13
Brain alternative polyA 0 0.000 1.04
Brain alternative TSS 1 0.058 1.20
Brain gene expression 0 0.000 1.10
Brain isoform ratio 0 0.000 1.04
Brain intron excision ratio 0 0.000 1.10
Brain mRNA stability 0 0.000 1.09
Eye alternative polyA 0 0.000 1.00
Eye alternative TSS 0 0.000 0.99
Eye gene expression 0 0.000 1.02
Eye isoform ratio 0 0.000 1.26
Eye intron excision ratio 0 0.000 1.07
Eye mRNA stability 0 0.000 1.25
IL alternative polyA 0 0.000 1.09
IL alternative TSS 0 0.000 1.32
IL gene expression 0 0.000 1.11
IL isoform ratio 0 0.000 1.23
IL intron excision ratio 0 0.000 1.11
IL mRNA stability 0 0.000 1.13
LHb alternative polyA 0 0.000 0.96
LHb alternative TSS 0 0.000 1.13
LHb gene expression 0 0.000 1.13
LHb isoform ratio 0 0.000 1.17
LHb intron excision ratio 0 0.000 1.13
LHb mRNA stability 0 0.000 1.14
Liver alternative polyA 0 0.000 1.08
Liver alternative TSS 0 0.000 1.03
Liver gene expression 0 0.000 1.07
Liver isoform ratio 0 0.000 1.07
Liver intron excision ratio 0 0.000 1.12
Liver mRNA stability 0 0.000 1.08
NAcc alternative polyA 0 0.000 0.99
NAcc alternative TSS 0 0.000 1.21
NAcc gene expression 0 0.000 1.11
NAcc isoform ratio 0 0.000 1.07
NAcc intron excision ratio 0 0.000 1.09
NAcc mRNA stability 0 0.000 1.12
OFC alternative polyA 0 0.000 1.04
OFC alternative TSS 0 0.000 1.16
OFC gene expression 0 0.000 1.13
OFC isoform ratio 0 0.000 1.18
OFC intron excision ratio 0 0.000 1.17
OFC mRNA stability 0 0.000 1.11
PL alternative polyA 0 0.000 1.07
PL alternative TSS 0 0.000 1.19
PL gene expression 0 0.000 1.10
PL isoform ratio 0 0.000 1.05
PL intron excision ratio 0 0.000 1.06
PL mRNA stability 0 0.000 1.13

avg chisq: Average Chi2 (squared Z-score) across all models in this panel for this trait.