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Extinction: sum of active levers before priming

Sum of active levers on first 2 hours of within-session extinction-prime test

Tags: Behavior · Heroin

Project: u01_peter_kalivas

2 significantly associated models · 2 unique genes

Significant Loci

# chr p0 p1 # assoc genes # joint models best TWAS P best SNP P cond SNP P % var exp joint genes
1 1 68581504 69974370 1 1 1.3e-09 0.102 0.051 -42 Syt5
2 9 24497174 25018277 1 1 1.4e-07 0.017 1.000 100 Rims1

p0: physical position of the start of the locus. p1: physical position of the end of the locus. # joint models: number of models selected by step-wise conditional analysis.

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Body weight 2.6 1 0 0 0 1 Syt5
Epididymis fat weight 2.2 1 0 0 0 1 Syt5
Glucose 12.1 1 0 0 0 1 Syt5
Right kidney weight 2.2 2 0 0 0 1 Rims1 Syt5
Length without tail 3.2 1 0 0 0 1 Syt5
Liver weight, left 10.2 1 0 0 0 1 Syt5
Liver weight, right 7.2 2 0 0 0 1 Rims1 Syt5
Tibialis anterior weight 2.4 1 0 0 0 1 Syt5
Tibia length 7.5 1 0 0 0 1 Syt5
Std. dev. time between licks in bursts 22.7 1 1 50 0 1 Syt5
Indifference point 0 sec 6.3 1 0 0 0 1 Syt5
Indifference point function ln k 8.8 1 0 0 0 1 Syt5
Indifference point function log k 8.8 1 0 0 0 1 Syt5
Delay discounting total patch changes 0 sec 5.8 1 0 0 0 1 Syt5
Delay discounting total patch changes 24 sec 10.3 1 0 0 0 1 Syt5
Delay discounting time to switch 0 sec 55.9 1 1 50 0 1 Syt5
Delay discounting water rate 0 sec 10.3 1 0 0 0 1 Syt5
Delay discounting water rate 12 sec 22.1 1 1 50 0 1 Syt5
Delay discounting water rate 18 sec 19.1 1 0 0 0 1 Syt5
Delay discounting water rate 24 sec 8.0 1 0 0 0 1 Syt5
Light reinforcement 1 21.6 1 1 50 0 1 Syt5
Light reinforcement 2 14.6 2 1 50 0 1 Rims1 Syt5
Reaction time num false alarms AUC 10.6 1 0 0 0 1 Syt5
Reaction time mean 5.1 1 0 0 0 1 Syt5
Reaction time mean AUC 6.2 1 0 0 0 1 Syt5
Median of all reaction times 7.0 1 0 0 0 1 Syt5
Reaction time omissions 5.3 1 0 0 0 1 Syt5
Reaction time false alarm rate 4.7 1 0 0 0 1 Syt5
Social response proportion 8.0 1 0 0 0 1 Syt5
Social time 18.1 1 0 0 0 1 Syt5
Conditioned locomotion 5.9 1 0 0 0 1 Syt5
Cocaine response after cond. corrected 18.2 1 0 0 0 1 Syt5
Cocaine response after cond. not corrected 16.4 1 0 0 0 1 Syt5
Saline control response 13.2 1 0 0 0 1 Syt5
Condit. Reinf. lever presses 9.9 1 0 0 0 1 Syt5
Pavlov. Cond. change in total contacts 5.8 1 0 0 0 1 Syt5
Conditioned reinforcement - actives 22.3 1 0 0 0 1 Syt5
Conditioned reinforcement - inactives 5.5 1 0 0 0 1 Rims1
Conditioned locomotion 15.1 1 0 0 0 1 Syt5
Intermittent access intake day 1-15 change 7.2 1 0 0 0 1 Syt5
Intermittent access intake escalation 2 5.3 1 0 0 0 1 Syt5
Intermitt. access day 1 inactive lever presses 17.1 2 0 0 0 1 Rims1 Syt5
Intermitt. access day 15 inactive lever presses 23.1 2 1 50 0 1 Rims1 Syt5
Intermitt. access escalation Index 17.2 1 0 0 0 1 Syt5
Intermittent access total infusions 4.7 1 0 0 0 1 Rims1
Intermittent access standard deviation 9.3 1 0 0 0 1 Syt5
Post-drug Anxiety 10.2 1 0 0 0 1 Syt5
Baseline Anxiety 26.3 1 1 50 0 1 Syt5
Lifetime Intake 4.5 1 0 0 0 1 Rims1
Incentive Sensitization - Responses 7.6 2 0 0 0 1 Rims1 Syt5
Incentive Sensitization - Breakpoint 7.5 2 0 0 0 1 Rims1 Syt5
Progressive ratio test 1 active lever presses 11.7 1 0 0 0 1 Rims1
Progressive ratio test 1 breakpoint 14.1 1 0 0 0 1 Rims1
Progressive ratio test 2 active lever presses 14.2 1 0 0 0 1 Rims1
Progressive ratio test 2 breakpoint 16.4 1 0 0 0 1 Rims1
Short access day 1 total inactive lever presses 24.4 1 1 50 0 1 Syt5
Short access day 10 total inactive lever presses 17.2 2 1 50 0 1 Rims1 Syt5
Short access total infusions 5.5 1 0 0 0 1 Rims1
Short access day 10 total locomotion 11.2 1 0 0 0 1 Syt5
Short access total locomotion 13.1 1 0 0 0 1 Syt5
One hour access (0.3 mA shock) 4.8 1 0 0 0 1 Rims1
One hour access (shock baseline) 24.4 1 1 50 0 1 Syt5
Number of responses in last shaping day 9.8 1 0 0 0 1 Syt5
Context. condit. distance diff. score 4.3 1 0 0 0 1 Syt5
Locomotion velocity, session 1 61.5 1 1 50 0 1 Syt5
Locomotion distance, session 1 22.4 1 1 50 0 1 Syt5
Locomotion velocity, session 2 20.6 1 0 0 0 1 Syt5
Locomotion distance, session 2 5.4 1 0 0 0 1 Syt5
Locomotion velocity, session 3 6.6 1 0 0 0 1 Rims1
Locomotion distance, session 3 8.7 1 0 0 0 1 Syt5
Locomotion velocity, session 7 6.0 1 0 0 0 1 Syt5
Locomotion distance, session 7 10.2 1 0 0 0 1 Syt5
Locomotion velocity, session 8 15.7 1 0 0 0 1 Syt5
Locomotion distance, session 8 9.2 1 0 0 0 1 Syt5
Time in familiar zone, hab. session 1 12.8 1 0 0 0 1 Syt5
Total zone transitions, hab. session 1 25.5 1 1 50 0 1 Syt5
Total locomotion distance, hab. session 1 19.3 1 1 50 0 1 Syt5
Locomotion velocity, hab. session 1 12.3 1 0 0 0 1 Syt5
Time in familiar zone, hab. session 2 14.1 1 0 0 0 1 Syt5
Total zone transitions, hab. session 2 7.9 1 0 0 0 1 Syt5
Total locomotion distance, hab. session 2 10.7 1 0 0 0 1 Syt5
Locomotion velocity, hab. session 2 13.6 1 0 0 0 1 Syt5
Total zone transitions, NPP test 4.1 1 0 0 0 1 Syt5
Pavlov. Cond. magazine entry latency 10.4 1 0 0 0 1 Syt5
Pavlov. Cond. lever contacts 4.8 1 0 0 0 1 Syt5
Pavlov. Cond. intertrial magazine entries 19.5 1 0 0 0 1 Syt5
Pavlov. Cond. response bias 13.4 1 0 0 0 1 Syt5
Bone: cortical porosity 7.7 1 0 0 0 1 Syt5
Bone: cortical thickness 3.2 1 0 0 0 1 Syt5
Bone: elastic displacement 7.7 1 0 0 0 1 Syt5
Bone: elastic work 5.8 1 0 0 0 1 Syt5
Bone: post-yield work 11.6 1 0 0 0 1 Syt5
Bone: stiffness 4.5 1 0 0 0 1 Syt5
Bone: tissue strength 13.1 1 0 0 0 1 Syt5
Bone: trabecular tissue density 8.2 1 0 0 0 1 Syt5
Distance traveled before self-admin 31.7 2 1 50 0 1 Rims1 Syt5
Distance traveled after self-admin 30.8 2 1 50 0 1 Rims1 Syt5
Delta time in open arm before/after self-admin 18.0 1 0 0 0 1 Syt5
Diff in mean of infusions in LGA sessions 20.4 1 0 0 0 1 Syt5
Active lever presses in extinction session 6 17.9 1 0 0 0 1 Syt5
Delta distance traveled before/after self-admin 12.2 1 0 0 0 1 Rims1
Delta ambulatory time before/after self-admin 5.3 1 0 0 0 1 Rims1
Time in closed arm after self-admin 14.9 2 0 0 0 1 Rims1 Syt5
Time in open arm after self-admin 17.1 1 0 0 0 1 Syt5
Sum of active levers in priming session hrs 5-6 17.2 1 0 0 0 1 Syt5
Time to tail flick, vehicle, before self-admin 9.4 1 0 0 0 1 Rims1
Time to tail flick, test, before self-admin 57.2 1 1 50 0 1 Syt5
Time to tail flick, test, after self-admin 5.7 1 0 0 0 1 Syt5
Delta time to tail flick, vehicle, before/after SA 8.6 1 0 0 0 1 Syt5
Delta time to tail flick, test, before/after SA 42.4 1 1 50 0 1 Syt5
Ambulatory time before self-admin 36.6 1 1 50 0 1 Syt5
Ambulatory time after self-admin 61.3 1 1 50 0 1 Syt5
Total heroin consumption 5.8 1 0 0 0 1 Syt5
Delay disc. indifference point, 0s delay 28.0 1 1 50 0 1 Syt5
Delay disc. indifference point, 16s delay 24.1 1 0 0 0 1 Syt5
Delay disc. indifference point, 24s delay 9.6 1 0 0 0 1 Syt5
Change in fecal boli incidents, locomotor task 6.2 1 0 0 0 1 Syt5
Time >=10cm from walls, locomotor time 1 29.0 1 1 50 0 1 Rims1
Bouts of movement, locomotor time 1 31.4 2 1 50 0 1 Rims1 Syt5
Total resting periods, locomotor time 1 22.1 2 1 50 0 1 Rims1 Syt5
Vertical activity count, locomotor time 1 15.2 2 0 0 0 1 Rims1 Syt5
Bouts of movement, locomotor time 2 26.4 1 1 50 0 1 Rims1
Total resting periods, locomotor time 2 30.9 1 1 50 0 1 Rims1
Rest time, locomotor task time 2 6.8 2 0 0 0 1 Rims1 Syt5
Vertical activity count, locomotor time 2 5.6 1 0 0 0 1 Syt5
Weight adjusted by age 8.3 1 0 0 0 1 Syt5
Seeking ratio, delayed vs. immediate footshock 29.7 1 1 50 0 1 Syt5
Locomotion in novel chamber 12.7 1 0 0 0 1 Syt5
Locomotion in novel chamber post-restriction 5.2 1 0 0 0 1 Rims1
Progressive ratio 7.6 1 0 0 0 1 Syt5
Food seeking constrained by brief footshock 133.4 1 1 50 0 1 Syt5
Seeking ratio, punishment vs. effort 16.5 1 0 0 0 1 Syt5
Run reversals in cocaine runway, females 8.3 1 0 0 0 1 Syt5
Cd content in liver 7.7 1 0 0 0 1 Syt5
Co content in liver 19.4 1 0 0 0 1 Syt5
Rb content in liver 6.5 1 0 0 0 1 Syt5
Sr content in liver 66.7 1 1 50 0 1 Syt5
Zn content in liver 12.4 1 0 0 0 1 Syt5

chisq ratio: Average Chi2 statistic for the selected genes in the secondary trait, divided by the average statistic for all genes in the secondary trait. # genes+: Shared significant genes at Bonferroni correction. # genes++: Shared significant genes at transcriptome-wide significance. % genes++: Number of [++] genes as a percentage of primary trait’s total joint genes. corr: Correlation of effect sizes across the [+] genes.

Associations by panel

tissue modality # hits % hits/tests avg chisq
Adipose alternative polyA 0 0.000 0.96
Adipose alternative TSS 0 0.000 1.05
Adipose gene expression 0 0.000 1.02
Adipose isoform ratio 0 0.000 1.02
Adipose intron excision ratio 0 0.000 0.83
Adipose mRNA stability 0 0.000 1.01
BLA alternative polyA 0 0.000 1.13
BLA alternative TSS 0 0.000 1.09
BLA gene expression 0 0.000 1.04
BLA isoform ratio 0 0.000 1.06
BLA intron excision ratio 0 0.000 0.94
BLA mRNA stability 1 0.049 1.00
Brain alternative polyA 0 0.000 1.07
Brain alternative TSS 0 0.000 1.07
Brain gene expression 0 0.000 1.02
Brain isoform ratio 0 0.000 1.03
Brain intron excision ratio 0 0.000 0.95
Brain mRNA stability 0 0.000 1.01
Eye alternative polyA 0 0.000 1.12
Eye alternative TSS 0 0.000 1.19
Eye gene expression 0 0.000 1.02
Eye isoform ratio 0 0.000 1.14
Eye intron excision ratio 0 0.000 1.01
Eye mRNA stability 0 0.000 1.11
IL alternative polyA 0 0.000 1.13
IL alternative TSS 0 0.000 1.08
IL gene expression 0 0.000 1.03
IL isoform ratio 0 0.000 1.00
IL intron excision ratio 0 0.000 0.99
IL mRNA stability 0 0.000 1.01
LHb alternative polyA 0 0.000 1.09
LHb alternative TSS 0 0.000 1.30
LHb gene expression 0 0.000 1.02
LHb isoform ratio 0 0.000 1.02
LHb intron excision ratio 0 0.000 0.96
LHb mRNA stability 0 0.000 1.08
Liver alternative polyA 0 0.000 0.96
Liver alternative TSS 0 0.000 1.04
Liver gene expression 0 0.000 1.00
Liver isoform ratio 0 0.000 1.04
Liver intron excision ratio 0 0.000 0.96
Liver mRNA stability 0 0.000 1.07
NAcc alternative polyA 0 0.000 1.15
NAcc alternative TSS 0 0.000 1.09
NAcc gene expression 1 0.016 1.03
NAcc isoform ratio 0 0.000 1.02
NAcc intron excision ratio 0 0.000 0.95
NAcc mRNA stability 0 0.000 0.97
OFC alternative polyA 0 0.000 0.95
OFC alternative TSS 0 0.000 1.17
OFC gene expression 0 0.000 1.01
OFC isoform ratio 0 0.000 0.99
OFC intron excision ratio 0 0.000 1.00
OFC mRNA stability 0 0.000 1.02
PL alternative polyA 0 0.000 1.09
PL alternative TSS 0 0.000 1.17
PL gene expression 0 0.000 1.02
PL isoform ratio 0 0.000 1.00
PL intron excision ratio 0 0.000 0.98
PL mRNA stability 0 0.000 1.01

avg chisq: Average Chi2 (squared Z-score) across all models in this panel for this trait.