Hub : Traits

Extinction: sum of active levers before priming

Sum of active levers on first 2 hours of within-session extinction-prime test

Tags: Behavior · Heroin

Project: u01_peter_kalivas

7 loci · 7 genes with independent associations · 7 total associated genes

Significant Loci

#	Chr	Start pos	End pos	# assoc genes	# joint models	Best TWAS P	Best GWAS P	Cond GWAS P	Joint genes
1	chr3	89719707	91113777	1	1	2.97e-08	1.96e-02	3.70e-05	Slc43a3
2	chr5	170075070	170847497	1	1	1.16e-15	6.67e-02	1.00e+00	Arhgef16
3	chr7	92127461	93066096	1	1	3.47e-11	8.78e-02	1.00e+00	Ndufb9
4	chr8	41432021	42517271	1	1	2.15e-10	4.10e-01	1.49e-05	Foxred1
5	chr8	117463629	118343328	1	1	1.17e-15	2.43e-02	1.00e+00	Mst1
6	chr9	83390749	84777604	1	1	0.00e+00	3.97e-01	1.00e+00	Retreg2
7	chr17	61510864	62906219	1	1	3.19e-60	2.26e-01	1.28e-10	Ccny

Pleiotropic Associations

Trait	Chi2 ratio	# genes+	# genes++	% genes++	Corr	Corr P	Genes
BMI with tail	1284.56	3	2	28.6	0	1.00e+00	Foxred1 Ndufb9 Retreg2
BMI without tail	48012.24	3	3	42.9	0	1.00e+00	Ccny Ndufb9 Retreg2
Body weight	8.23	3	2	28.6	0	1.00e+00	Mst1 Ndufb9 Retreg2
Epididymis fat weight	27130.87	4	3	42.9	1	5.74e-05	Ccny Mst1 Ndufb9 Retreg2
Glucose	825.95	3	2	28.6	0	1.00e+00	Mst1 Ndufb9 Retreg2
Heart weight	4511.78	3	2	28.6	0	1.00e+00	Ccny Ndufb9 Retreg2
Left kidney weight	35317.15	4	2	28.6	-1	2.65e-04	Ccny Foxred1 Ndufb9 Retreg2
Right kidney weight	23376.49	5	4	57.1	-1	3.39e-06	Ccny Foxred1 Mst1 Ndufb9 Retreg2
Tail length	30711.52	3	2	28.6	0	1.00e+00	Ccny Mst1 Retreg2
Length with tail	1232.15	5	3	42.9	1	9.12e-05	Foxred1 Mst1 Ndufb9 Retreg2 Slc43a3
Length without tail	32336.19	4	3	42.9	-1	1.39e-04	Ccny Mst1 Ndufb9 Retreg2
Liver weight, left	3639.22	4	3	42.9	-1	8.10e-04	Ccny Mst1 Ndufb9 Retreg2
Liver weight, right	75	4	2	28.6	-0.9	1.05e-01	Ccny Mst1 Ndufb9 Retreg2
Parametrial fat weight	157.8	4	1	14.3	0.99	6.78e-03	Ccny Foxred1 Retreg2 Slc43a3
Retroperitoneal fat weight	5360.99	3	2	28.6	0	1.00e+00	Arhgef16 Mst1 Retreg2
Intraocular pressure	40071.91	1	1	14.3	0	1.00e+00	Retreg2
Extensor digitorum longus weight	1564.03	3	1	14.3	0	1.00e+00	Arhgef16 Mst1 Retreg2
Soleus weight	33.49	4	2	28.6	0.91	8.55e-02	Arhgef16 Ccny Ndufb9 Retreg2
Tibialis anterior weight	2448.56	2	2	28.6	0	1.00e+00	Arhgef16 Retreg2
Tibia length	822.86	4	2	28.6	0.99	5.64e-03	Arhgef16 Mst1 Ndufb9 Retreg2
Number of licking bursts	78561.42	2	1	14.3	0	1.00e+00	Ccny Retreg2
Food consumed during 24 hour testing period	26562.71	4	2	28.6	-1	2.91e-03	Arhgef16 Ccny Mst1 Retreg2
Times rat made contact with spout	109.84	3	1	14.3	0	1.00e+00	Arhgef16 Ndufb9 Retreg2
Mean time between licks in bursts	49879.07	4	2	28.6	1	1.47e-03	Arhgef16 Ccny Ndufb9 Retreg2
Mean num. licks in bursts	47536.44	3	1	14.3	0	1.00e+00	Arhgef16 Ccny Retreg2
Std. dev. time between licks in bursts	31351.49	3	1	14.3	0	1.00e+00	Arhgef16 Mst1 Retreg2
Water consumed over 24 hours	51711.02	2	1	14.3	0	1.00e+00	Ccny Retreg2
Patch foraging indifference point 0 sec	57504.14	2	1	14.3	0	1.00e+00	Mst1 Retreg2
Patch foraging indifference point AUC	33311.57	4	3	42.9	-1	5.59e-04	Ccny Mst1 Ndufb9 Retreg2
Indifference point function ln k	35546.2	4	4	57.1	1	3.61e-04	Ccny Mst1 Ndufb9 Retreg2
Indifference point function log k	35546.2	4	4	57.1	1	3.61e-04	Ccny Mst1 Ndufb9 Retreg2
Patch foraging total patch changes 0 sec	60133.63	2	1	14.3	0	1.00e+00	Mst1 Retreg2
Patch foraging total patch changes 12 sec	2220.89	5	4	57.1	1	5.78e-05	Ccny Foxred1 Mst1 Ndufb9 Retreg2
Patch foraging total patch changes 18 sec	29448.67	4	1	14.3	1	2.72e-04	Ccny Mst1 Ndufb9 Retreg2
Patch foraging total patch changes 24 sec	41794.2	4	4	57.1	1	3.42e-04	Ccny Mst1 Ndufb9 Retreg2
Patch foraging total patch changes 6 sec	10907.3	3	3	42.9	0	1.00e+00	Ccny Ndufb9 Retreg2
Patch foraging time to switch 0 sec	52210.5	3	2	28.6	0	1.00e+00	Mst1 Ndufb9 Retreg2
Patch foraging water rate 0 sec	74407.03	2	1	14.3	0	1.00e+00	Ndufb9 Retreg2
Patch foraging water rate 12 sec	53969.51	3	2	28.6	0	1.00e+00	Ccny Mst1 Retreg2
Patch foraging water rate 18 sec	20659.7	5	1	14.3	-1	2.64e-05	Arhgef16 Ccny Mst1 Ndufb9 Retreg2
Patch foraging water rate 24 sec	1575.07	3	2	28.6	0	1.00e+00	Ccny Mst1 Retreg2
Patch foraging water rate 6 sec	1363.06	3	3	42.9	0	1.00e+00	Ccny Ndufb9 Retreg2
Locomotor activity	24.52	4	2	28.6	0.51	4.94e-01	Ccny Foxred1 Mst1 Retreg2
Locomotor testing distance	14932.34	6	3	42.9	-1	1.92e-05	Arhgef16 Ccny Foxred1 Mst1 Ndufb9 Retreg2
Locomotor testing rearing	38108.7	4	2	28.6	-1	3.65e-05	Foxred1 Mst1 Ndufb9 Retreg2
Light reinforcement 1	77669.42	2	2	28.6	0	1.00e+00	Ccny Retreg2
Light reinforcement 2	27019.19	4	3	42.9	-1	3.75e-04	Ccny Mst1 Ndufb9 Retreg2
Reaction time number correct	51168.28	3	3	42.9	0	1.00e+00	Ccny Ndufb9 Retreg2
Reaction time mean minus median	51454.06	4	1	14.3	1	4.03e-04	Ccny Mst1 Ndufb9 Retreg2
Reaction time mean minus median AUC	52102.96	4	3	42.9	1	4.52e-04	Arhgef16 Mst1 Ndufb9 Retreg2
Reaction time num false alarms	19041.41	3	2	28.6	0	1.00e+00	Ccny Mst1 Retreg2
Reaction time num false alarms AUC	35512.53	3	2	28.6	0	1.00e+00	Ccny Mst1 Retreg2
Reaction time trials correct on left	51168.28	3	3	42.9	0	1.00e+00	Ccny Ndufb9 Retreg2
Reaction time trials on left	50013.45	3	3	42.9	0	1.00e+00	Ccny Ndufb9 Retreg2
Reaction time mean	31463.75	3	1	14.3	0	1.00e+00	Arhgef16 Ccny Retreg2
Reaction time mean AUC	37784.15	3	1	14.3	0	1.00e+00	Arhgef16 Ccny Retreg2
Median of all reaction times	15718.31	2	2	28.6	0	1.00e+00	Arhgef16 Retreg2
Reaction time omissions	17137.2	2	1	14.3	0	1.00e+00	Ndufb9 Retreg2
Reaction time false alarm rate	302.63	3	1	14.3	0	1.00e+00	Mst1 Ndufb9 Retreg2
Reaction time premature initiation rate	9227.85	4	2	28.6	-1	2.64e-03	Arhgef16 Ccny Retreg2 Slc43a3
Reaction time premature initiations	46243.53	3	1	14.3	0	1.00e+00	Arhgef16 Ccny Retreg2
Std. dev. reaction times	49831.92	3	1	14.3	0	1.00e+00	Mst1 Ndufb9 Retreg2
Reaction time trials completed	50013.45	3	3	42.9	0	1.00e+00	Ccny Ndufb9 Retreg2
Reaction time trials AUC	50581.81	3	2	28.6	0	1.00e+00	Ccny Ndufb9 Retreg2
Social response proportion	17657.99	2	1	14.3	0	1.00e+00	Mst1 Retreg2
Social responses	1433	4	2	28.6	-1	1.65e-03	Ccny Mst1 Ndufb9 Retreg2
Social time	11064.04	4	1	14.3	1	2.79e-03	Arhgef16 Ccny Mst1 Retreg2
Conditioned locomotion	2039.45	3	2	28.6	0	1.00e+00	Arhgef16 Ccny Retreg2
Cocaine response after cond. corrected	21944.59	3	1	14.3	0	1.00e+00	Arhgef16 Ccny Retreg2
Cocaine response after cond. not corrected	21421.93	3	1	14.3	0	1.00e+00	Arhgef16 Ccny Retreg2
Cocaine response before conditioning	1409.02	2	1	14.3	0	1.00e+00	Ccny Retreg2
Saline control response	6522.43	2	2	28.6	0	1.00e+00	Mst1 Retreg2
Condit. Reinf. active minus inactive responses	26712.34	2	1	14.3	0	1.00e+00	Mst1 Retreg2
Condit. Reinf. active-inactive response ratio	45793.79	2	1	14.3	0	1.00e+00	Ndufb9 Retreg2
Condit. Reinf. active responses	4856.3	2	2	28.6	0	1.00e+00	Mst1 Retreg2
Condit. Reinf. inactive responses	14046.99	3	2	28.6	0	1.00e+00	Ccny Mst1 Retreg2
Condit. Reinf. lever presses	5308.92	3	2	28.6	0	1.00e+00	Mst1 Ndufb9 Retreg2
Condit. Reinf. lever reinforcers received	1007.39	2	1	14.3	0	1.00e+00	Mst1 Retreg2
Pavlov. Cond. lever latency	5465.68	2	1	14.3	0	1.00e+00	Mst1 Retreg2
Pavlov. Cond. magazine entry latency	12390.63	4	2	28.6	1	1.60e-03	Arhgef16 Ccny Mst1 Retreg2
Pavlov. Cond. change in total contacts	57393.18	2	1	14.3	0	1.00e+00	Ndufb9 Retreg2
Pavlov. Cond. index score	12013.04	4	2	28.6	1	1.42e-03	Arhgef16 Ccny Mst1 Retreg2
Pavlov. Cond. latency score	14633.13	4	2	28.6	1	1.27e-03	Arhgef16 Ccny Mst1 Retreg2
Pavlov. Cond. lever contacts	7370.31	3	2	28.6	0	1.00e+00	Arhgef16 Mst1 Retreg2
Pavlov. Cond. magazine entry number	8453.95	2	2	28.6	0	1.00e+00	Mst1 Retreg2
Pavlov. Cond. intertrial magazine entries	52501.71	2	2	28.6	0	1.00e+00	Mst1 Retreg2
Pavlov. Cond. lever-magazine prob. diff.	11234.75	4	2	28.6	1	1.61e-03	Arhgef16 Ccny Mst1 Retreg2
Pavlov. Cond. response bias	1754.98	3	2	28.6	0	1.00e+00	Arhgef16 Mst1 Retreg2
Conditioned reinforcement - actives	63842.12	3	3	42.9	0	1.00e+00	Ccny Ndufb9 Retreg2
Conditioned reinforcement - inactives	31027.43	5	4	57.1	1	3.78e-05	Ccny Foxred1 Mst1 Ndufb9 Retreg2
Conditioned locomotion	8308.95	5	3	42.9	1	9.69e-05	Ccny Foxred1 Mst1 Ndufb9 Retreg2
Intermittent access intake day 1-15 change	42126.62	5	3	42.9	1	2.53e-05	Ccny Foxred1 Mst1 Retreg2 Slc43a3
Intermittent access intake escalation	52395.12	4	2	28.6	1	2.75e-04	Foxred1 Mst1 Retreg2 Slc43a3
Intermittent access intake escalation 2	27045.81	4	3	42.9	1	2.37e-03	Ccny Foxred1 Mst1 Retreg2
Intermitt. access day 1 inactive lever presses	47312.71	5	2	28.6	1	3.19e-05	Ccny Mst1 Ndufb9 Retreg2 Slc43a3
Intermitt. access day 15 inactive lever presses	52076.79	4	3	42.9	1	6.64e-04	Foxred1 Ndufb9 Retreg2 Slc43a3
Intermitt. access escalation Index	37009.86	5	2	28.6	-1	2.12e-05	Ccny Mst1 Ndufb9 Retreg2 Slc43a3
Intermittent access day 1 total infusions	38884.39	4	1	14.3	-1	2.49e-04	Ccny Foxred1 Mst1 Retreg2
Intermittent access day 15 total infusions	32883.96	4	2	28.6	1	6.79e-04	Ccny Foxred1 Retreg2 Slc43a3
Intermittent access terminal intake (last 3 days)	20812.87	4	2	28.6	1	7.31e-04	Ccny Foxred1 Retreg2 Slc43a3
Intermittent access total infusions	177.7	4	1	14.3	-0.97	2.77e-02	Ccny Foxred1 Retreg2 Slc43a3
Intermittent access day 1 locomotion	34833.31	3	2	28.6	0	1.00e+00	Ccny Foxred1 Retreg2
Intermittent access day 15 total locomotion	88947.95	2	2	28.6	0	1.00e+00	Ccny Retreg2
Intermittent access total locomotion	185.43	4	1	14.3	1	4.95e-04	Mst1 Ndufb9 Retreg2 Slc43a3
Intermittent access standard deviation	50492.05	4	3	42.9	1	8.95e-04	Ccny Foxred1 Mst1 Retreg2
Cocaine induced anxiety	32070.55	5	3	42.9	-1	4.17e-05	Arhgef16 Ccny Foxred1 Ndufb9 Retreg2
Post-drug Anxiety	6831.55	3	2	28.6	0	1.00e+00	Arhgef16 Ndufb9 Retreg2
Baseline Anxiety	25920.66	4	3	42.9	1	5.08e-04	Ccny Foxred1 Ndufb9 Retreg2
Lifetime Intake	1724.12	4	2	28.6	-1	4.72e-03	Ccny Foxred1 Retreg2 Slc43a3
Incentive Sensitization - Responses	40904.49	4	3	42.9	-1	9.31e-04	Ccny Ndufb9 Retreg2 Slc43a3
Incentive Sensitization - Breakpoint	28566.39	5	3	42.9	-1	3.64e-05	Ccny Foxred1 Ndufb9 Retreg2 Slc43a3
Progressive ratio test 1 active lever presses	33313.84	3	2	28.6	0	1.00e+00	Ccny Ndufb9 Retreg2
Progressive ratio test 1 breakpoint	32105.23	3	2	28.6	0	1.00e+00	Ccny Ndufb9 Retreg2
Progressive ratio test 1 inactive lever presses	30229.54	5	4	57.1	1	2.22e-05	Ccny Foxred1 Mst1 Ndufb9 Retreg2
Progressive ratio test 2 active lever presses	19090.97	3	2	28.6	0	1.00e+00	Ccny Ndufb9 Retreg2
Progressive ratio test 2 breakpoint	17520.06	2	2	28.6	0	1.00e+00	Ccny Retreg2
Progressive ratio test 2 inactive lever presses	32826.56	5	2	28.6	1	1.79e-05	Ccny Foxred1 Mst1 Ndufb9 Retreg2
Total sessions with >9 infusions	2022.19	4	3	42.9	-0.99	8.71e-03	Ccny Mst1 Retreg2 Slc43a3
Short access day 1 total inactive lever presses	22896.59	5	4	57.1	-1	4.72e-05	Ccny Foxred1 Mst1 Ndufb9 Retreg2
Short access day 10 total inactive lever presses	72421.44	3	3	42.9	0	1.00e+00	Ccny Mst1 Retreg2
Short access day 1 total infusions	22349.03	5	2	28.6	-1	5.04e-05	Arhgef16 Ccny Foxred1 Mst1 Retreg2
Short access day 10 total infusions	19085.03	4	3	42.9	-1	5.04e-04	Ccny Mst1 Ndufb9 Retreg2
Short access total infusions	17026.24	2	2	28.6	0	1.00e+00	Ccny Retreg2
Short access day 1 locomotion	14028.19	6	3	42.9	1	1.02e-05	Arhgef16 Ccny Foxred1 Ndufb9 Retreg2 Slc43a3
Short access day 10 total locomotion	36326.51	5	3	42.9	1	5.22e-05	Ccny Foxred1 Mst1 Retreg2 Slc43a3
Short access total locomotion	11389.19	6	3	42.9	1	1.70e-06	Arhgef16 Foxred1 Mst1 Ndufb9 Retreg2 Slc43a3
Compulsive drug intake	13097.33	5	2	28.6	-1	1.83e-05	Ccny Foxred1 Mst1 Ndufb9 Retreg2
One hour access (0.3 mA shock)	2446.39	4	3	42.9	0.99	1.05e-02	Ccny Foxred1 Ndufb9 Retreg2
One hour access (shock baseline)	46760.13	3	1	14.3	0	1.00e+00	Ccny Foxred1 Retreg2
Number of responses in last shaping day	17140.43	3	2	28.6	0	1.00e+00	Ccny Foxred1 Retreg2
Context. condit. distance diff. score	970.59	1	1	14.3	0	1.00e+00	Retreg2
Locomotion velocity, session 1	7315.11	2	1	14.3	0	1.00e+00	Ndufb9 Retreg2
Locomotion distance, session 1	2213.01	2	1	14.3	0	1.00e+00	Ccny Retreg2
Locomotion velocity, session 2	4702.2	2	2	28.6	0	1.00e+00	Mst1 Retreg2
Locomotion distance, session 2	806.64	3	1	14.3	0	1.00e+00	Ccny Mst1 Retreg2
Locomotion velocity, session 3	2332.53	1	1	14.3	0	1.00e+00	Retreg2
Locomotion distance, session 3	16615.78	1	1	14.3	0	1.00e+00	Retreg2
Stereotopy head waving bouts, day 3	2943.11	2	1	14.3	0	1.00e+00	Mst1 Retreg2
Stereotopy head waving duration, day 3	6074.03	2	1	14.3	0	1.00e+00	Mst1 Retreg2
Locomotion velocity, session 7	708.6	2	2	28.6	0	1.00e+00	Mst1 Retreg2
Locomotion distance, session 7	1294.52	3	2	28.6	0	1.00e+00	Mst1 Ndufb9 Retreg2
Stereotopy head waving bouts, day 7	5257.18	2	2	28.6	0	1.00e+00	Ndufb9 Retreg2
Stereotopy head waving duration, day 7	4446.48	2	2	28.6	0	1.00e+00	Ndufb9 Retreg2
Locomotion velocity, session 8	950.4	2	1	14.3	0	1.00e+00	Ccny Retreg2
Locomotion distance, session 8	673.32	1	1	14.3	0	1.00e+00	Retreg2
Degree of sensitization distance	7696.03	2	2	28.6	0	1.00e+00	Mst1 Retreg2
Degree of sensitization stereotypy	2841.03	3	1	14.3	0	1.00e+00	Mst1 Ndufb9 Retreg2
Condit. Reinf. active minus inactive responses	2066.34	2	1	14.3	0	1.00e+00	Ccny Retreg2
Condit. Reinf. active-inactive response ratio	1097.66	1	1	14.3	0	1.00e+00	Retreg2
Condit. Reinf. active responses	3894.77	3	1	14.3	0	1.00e+00	Arhgef16 Ccny Retreg2
Condit. Reinf. inactive responses	6466.37	3	1	14.3	0	1.00e+00	Mst1 Ndufb9 Retreg2
Incentive salience index mean	3704.56	4	1	14.3	1	1.92e-04	Arhgef16 Ccny Mst1 Retreg2
Condit. Reinf. lever presses	7159.95	3	2	28.6	0	1.00e+00	Arhgef16 Mst1 Retreg2
Time in familiar zone, hab. session 1	20942.14	2	1	14.3	0	1.00e+00	Mst1 Retreg2
Time in novel zone, hab. session 1	17770.84	2	1	14.3	0	1.00e+00	Mst1 Retreg2
Total zone transitions, hab. session 1	916.07	2	1	14.3	0	1.00e+00	Ndufb9 Retreg2
Total locomotion distance, hab. session 1	849.35	2	1	14.3	0	1.00e+00	Ccny Retreg2
Locomotion velocity, hab. session 1	571.33	2	1	14.3	0	1.00e+00	Ccny Retreg2
Time in familiar zone, hab. session 2	11707.23	2	2	28.6	0	1.00e+00	Mst1 Retreg2
Time in novel zone, hab. session 2	12499.19	2	2	28.6	0	1.00e+00	Mst1 Retreg2
Total zone transitions, hab. session 2	99.53	3	1	14.3	0	1.00e+00	Mst1 Ndufb9 Retreg2
Total locomotion distance, hab. session 2	51.92	2	1	14.3	0	1.00e+00	Ccny Retreg2
Locomotion velocity, hab. session 2	77.91	2	1	14.3	0	1.00e+00	Ccny Retreg2
Novel to familiar place preference ratio	18511.87	3	1	14.3	0	1.00e+00	Ccny Mst1 Retreg2
Novelty place preference	18137	3	1	14.3	0	1.00e+00	Ccny Mst1 Retreg2
Time in novel zone, NPP test	20429.72	2	1	14.3	0	1.00e+00	Mst1 Retreg2
Total zone transitions, NPP test	2755.02	3	2	28.6	0	1.00e+00	Arhgef16 Ndufb9 Retreg2
Total locomotion distance, NPP test	3566.83	2	2	28.6	0	1.00e+00	Ccny Retreg2
Locomotion velocity, NPP test	2031.76	2	2	28.6	0	1.00e+00	Ccny Retreg2
Pavlov. Cond. lever latency	749.34	3	2	28.6	0	1.00e+00	Arhgef16 Mst1 Retreg2
Pavlov. Cond. magazine entry latency	8.88	2	0	0	0	1.00e+00	Arhgef16 Ccny
Pavlov. Cond. change in total contacts	2273.55	2	1	14.3	0	1.00e+00	Ccny Retreg2
Pavlov. Cond. index score	602.72	3	2	28.6	0	1.00e+00	Arhgef16 Mst1 Retreg2
Pavlov. Cond. latency score	626.71	3	2	28.6	0	1.00e+00	Arhgef16 Mst1 Retreg2
Pavlov. Cond. lever contacts	774.93	4	2	28.6	-0.98	1.95e-02	Arhgef16 Mst1 Ndufb9 Retreg2
Pavlov. Cond. magazine entry number	546.58	4	1	14.3	0.99	1.42e-02	Arhgef16 Ccny Mst1 Retreg2
Pavlov. Cond. intertrial magazine entries	144.49	4	2	28.6	0.93	6.72e-02	Arhgef16 Mst1 Ndufb9 Retreg2
Pavlov. Cond. lever-magazine prob. diff.	655.39	3	1	14.3	0	1.00e+00	Arhgef16 Mst1 Retreg2
Pavlov. Cond. response bias	877.59	3	1	14.3	0	1.00e+00	Arhgef16 Mst1 Retreg2
Bone: apparent density	11138.75	2	1	14.3	0	1.00e+00	Ndufb9 Retreg2
Bone surface	12570.47	2	2	28.6	0	1.00e+00	Mst1 Retreg2
Bone volume	16919.6	2	1	14.3	0	1.00e+00	Mst1 Retreg2
Bone: connectivity density	2373.11	3	1	14.3	0	1.00e+00	Mst1 Ndufb9 Retreg2
Bone: cortical apparent density	15092.86	3	1	14.3	0	1.00e+00	Ccny Ndufb9 Retreg2
Bone: cortical area	6332.51	3	2	28.6	0	1.00e+00	Mst1 Ndufb9 Retreg2
Bone: cortical porosity	466.39	4	1	14.3	-0.99	7.92e-03	Arhgef16 Mst1 Ndufb9 Retreg2
Bone: cortical porosity	2407.81	2	1	14.3	0	1.00e+00	Ndufb9 Retreg2
Bone: cortical thickness	426.41	4	2	28.6	-0.97	2.76e-02	Arhgef16 Mst1 Ndufb9 Retreg2
Bone: cortical thickness	3062.55	4	2	28.6	-1	3.40e-03	Arhgef16 Mst1 Ndufb9 Retreg2
Bone: cortical tissue density	16155.62	3	1	14.3	0	1.00e+00	Ccny Ndufb9 Retreg2
Bone: elastic displacement	29626.25	1	1	14.3	0	1.00e+00	Retreg2
Bone: elastic work	757.88	2	2	28.6	0	1.00e+00	Mst1 Retreg2
Bone: endosteal estimation	11756.25	3	1	14.3	0	1.00e+00	Mst1 Ndufb9 Retreg2
Bone: endosteal perimeter	14902.85	3	1	14.3	0	1.00e+00	Arhgef16 Mst1 Retreg2
Bone: final force	3544.85	2	2	28.6	0	1.00e+00	Mst1 Retreg2
Bone: final moment	548.75	2	2	28.6	0	1.00e+00	Mst1 Retreg2
Bone: marrow area	12360.31	3	1	14.3	0	1.00e+00	Mst1 Ndufb9 Retreg2
Bone: maximum diameter	8150.69	3	2	28.6	0	1.00e+00	Mst1 Ndufb9 Retreg2
Bone: maximum force	17305.93	2	2	28.6	0	1.00e+00	Mst1 Retreg2
Bone: maximum moment	12386.14	2	2	28.6	0	1.00e+00	Mst1 Retreg2
Bone: minimum diameter	8606.13	2	2	28.6	0	1.00e+00	Mst1 Retreg2
Bone: periosteal estimation	19111.51	2	2	28.6	0	1.00e+00	Mst1 Retreg2
Bone: periosteal perimeter	21606.9	2	2	28.6	0	1.00e+00	Mst1 Retreg2
Bone: post-yield work	25428.45	2	1	14.3	0	1.00e+00	Mst1 Retreg2
Bone: stiffness	17808.98	2	2	28.6	0	1.00e+00	Mst1 Retreg2
Bone: tissue strength	6137.24	2	1	14.3	0	1.00e+00	Arhgef16 Retreg2
Bone: trabecular number	13724.59	3	2	28.6	0	1.00e+00	Arhgef16 Ndufb9 Retreg2
Bone: trabecular spacing	10445.17	3	3	42.9	0	1.00e+00	Mst1 Ndufb9 Retreg2
Bone: trabecular thickness	16647.3	2	2	28.6	0	1.00e+00	Mst1 Retreg2
Bone: trabecular tissue density	10735.86	5	4	57.1	1	1.09e-04	Arhgef16 Ccny Mst1 Ndufb9 Retreg2
Breakpoint value in progressive ratio session	37483.32	3	1	14.3	0	1.00e+00	Ccny Mst1 Retreg2
Distance traveled before self-admin	33523.13	4	2	28.6	1	5.36e-06	Ccny Foxred1 Ndufb9 Retreg2
Distance traveled after self-admin	33650.45	3	2	28.6	0	1.00e+00	Ccny Foxred1 Retreg2
Delta time in closed arm before/after self-admin	421.49	5	2	28.6	0.88	5.00e-02	Arhgef16 Ccny Foxred1 Ndufb9 Retreg2
Delta time in open arm before/after self-admin	27441.91	2	2	28.6	0	1.00e+00	Ccny Retreg2
Diff in mean of infusions in LGA sessions	36170.06	3	1	14.3	0	1.00e+00	Mst1 Ndufb9 Retreg2
Active lever presses in extinction session 6	846.81	4	2	28.6	-0.95	5.08e-02	Ccny Foxred1 Mst1 Retreg2
Delta distance traveled before/after self-admin	3155.64	4	3	42.9	-0.99	6.40e-03	Ccny Foxred1 Ndufb9 Retreg2
Delta ambulatory time before/after self-admin	24030.85	4	2	28.6	-1	5.56e-05	Ccny Foxred1 Ndufb9 Retreg2
Time in closed arm before self-admin	17664.9	5	3	42.9	-1	4.56e-06	Ccny Foxred1 Mst1 Retreg2 Slc43a3
Time in closed arm after self-admin	6616.57	3	3	42.9	0	1.00e+00	Ccny Mst1 Retreg2
Time in open arm before self-admin	8700.62	4	3	42.9	-0.99	5.92e-03	Ccny Mst1 Ndufb9 Retreg2
Time in open arm after self-admin	416.29	5	4	57.1	0.94	1.86e-02	Ccny Foxred1 Mst1 Ndufb9 Retreg2
Sum of active levers in priming session hrs 5-6	1311.32	3	2	28.6	0	1.00e+00	Ndufb9 Retreg2 Slc43a3
Time to tail flick, vehicle, before self-admin	8652.04	6	2	28.6	1	3.99e-06	Ccny Foxred1 Mst1 Ndufb9 Retreg2 Slc43a3
Time to tail flick, vehicle, after self-admin	29583.91	4	2	28.6	1	1.13e-03	Ccny Foxred1 Ndufb9 Retreg2
Time to tail flick, test, before self-admin	6584.18	5	3	42.9	-0.99	5.23e-04	Arhgef16 Ccny Foxred1 Ndufb9 Retreg2
Time to tail flick, test, after self-admin	1219.66	5	3	42.9	0.98	3.50e-03	Arhgef16 Ccny Foxred1 Ndufb9 Retreg2
Delta time to tail flick, vehicle, before/after SA	12309.52	3	3	42.9	0	1.00e+00	Ccny Mst1 Retreg2
Delta time to tail flick, test, before/after SA	14216.41	4	1	14.3	1	1.36e-05	Ccny Mst1 Ndufb9 Retreg2
Ambulatory time before self-admin	57052.95	3	3	42.9	0	1.00e+00	Ccny Foxred1 Retreg2
Ambulatory time after self-admin	29437.11	3	2	28.6	0	1.00e+00	Ccny Mst1 Retreg2
Total heroin consumption	287.04	4	4	57.1	0.91	8.80e-02	Arhgef16 Ccny Foxred1 Retreg2
Area under the delay curve	27218.3	3	2	28.6	0	1.00e+00	Arhgef16 Ccny Retreg2
Delay disc. indifference point, 0s delay	4742.79	2	1	14.3	0	1.00e+00	Arhgef16 Retreg2
Delay disc. indifference point, 16s delay	24963.81	3	2	28.6	0	1.00e+00	Arhgef16 Ccny Retreg2
Delay disc. indifference point, 2s delay	286.06	3	2	28.6	0	1.00e+00	Arhgef16 Ccny Retreg2
Delay disc. indifference point, 24s delay	33351.68	3	2	28.6	0	1.00e+00	Ccny Retreg2 Slc43a3
Delay disc. indifference point, 4s delay	870.6	3	2	28.6	0	1.00e+00	Ccny Ndufb9 Retreg2
Delay disc. indifference point, 8s delay	50743.74	2	2	28.6	0	1.00e+00	Arhgef16 Retreg2
Delay discount exponential model param	30131.71	2	2	28.6	0	1.00e+00	Arhgef16 Retreg2
Delay discount hyperbolic model param	22878.48	2	2	28.6	0	1.00e+00	Arhgef16 Retreg2
Fecal boli incidents, locomotor time 1	75084.64	2	1	14.3	0	1.00e+00	Ccny Retreg2
Change in fecal boli incidents, locomotor task	7889.79	3	3	42.9	0	1.00e+00	Ccny Ndufb9 Retreg2
Time >=10cm from walls, locomotor time 1	16438.93	3	2	28.6	0	1.00e+00	Ccny Ndufb9 Retreg2
Bouts of movement, locomotor time 1	20842.46	2	2	28.6	0	1.00e+00	Ccny Retreg2
Total resting periods, locomotor time 1	5936.78	2	2	28.6	0	1.00e+00	Ccny Retreg2
Rest time, locomotor task time 1	18996.95	4	1	14.3	1	5.53e-04	Ccny Ndufb9 Retreg2 Slc43a3
Distance moved, locomotor task time 1	39835.37	4	3	42.9	-1	7.98e-04	Ccny Ndufb9 Retreg2 Slc43a3
Vertical activity count, locomotor time 1	219061.96	1	1	14.3	0	1.00e+00	Retreg2
Time >=10cm from walls, locomotor time 2	80995.71	2	1	14.3	0	1.00e+00	Ccny Retreg2
Bouts of movement, locomotor time 2	43584.09	4	2	28.6	1	1.53e-03	Ccny Foxred1 Retreg2 Slc43a3
Total resting periods, locomotor time 2	47527.15	4	2	28.6	1	1.43e-03	Ccny Foxred1 Retreg2 Slc43a3
Rest time, locomotor task time 2	20954.51	4	2	28.6	-1	2.45e-03	Ccny Ndufb9 Retreg2 Slc43a3
Distance moved, locomotor task time 2	17217.33	2	2	28.6	0	1.00e+00	Ccny Retreg2
Vertical activity count, locomotor time 2	69238.05	2	2	28.6	0	1.00e+00	Ccny Retreg2
Weight adjusted by age	54026.61	3	3	42.9	0	1.00e+00	Ccny Ndufb9 Retreg2
Seeking ratio, delayed vs. immediate footshock	24709.08	2	2	28.6	0	1.00e+00	Ccny Retreg2
Locomotion in novel chamber	5467.09	3	3	42.9	0	1.00e+00	Ccny Ndufb9 Retreg2
Locomotion in novel chamber post-restriction	38664.11	4	1	14.3	-1	7.57e-04	Ccny Ndufb9 Retreg2 Slc43a3
Progressive ratio	52658.05	3	3	42.9	0	1.00e+00	Ccny Ndufb9 Retreg2
Food seeking constrained by brief footshock	3673.46	2	1	14.3	0	1.00e+00	Ndufb9 Retreg2
Seeking ratio, punishment vs. effort	39437.56	3	3	42.9	0	1.00e+00	Ccny Ndufb9 Retreg2
Run reversals in cocaine runway, females	12403.43	3	1	14.3	0	1.00e+00	Ccny Foxred1 Retreg2
Run reversals in cocaine runway, males	7498.24	4	2	28.6	1	2.70e-03	Ccny Foxred1 Ndufb9 Retreg2
Latency to leave start box in cocaine runway	19547.12	3	2	28.6	0	1.00e+00	Arhgef16 Ccny Retreg2
Latency to leave start box in cocaine runway, F	9474.62	3	2	28.6	0	1.00e+00	Arhgef16 Ndufb9 Retreg2
Latency to leave start box in cocaine runway, M	1844.55	4	2	28.6	-1	3.79e-03	Ccny Foxred1 Ndufb9 Retreg2
Co content in liver	4721.74	1	1	14.3	0	1.00e+00	Retreg2
Cu content in liver	67.14	3	1	14.3	0	1.00e+00	Arhgef16 Ndufb9 Retreg2
Fe content in liver	2832.41	2	1	14.3	0	1.00e+00	Arhgef16 Retreg2
K content in liver	3343.42	2	2	28.6	0	1.00e+00	Arhgef16 Retreg2
Mg content in liver	12257.29	2	1	14.3	0	1.00e+00	Arhgef16 Retreg2
Mn content in liver	1482.95	3	2	28.6	0	1.00e+00	Arhgef16 Ndufb9 Retreg2
Na content in liver	5560.54	3	2	28.6	0	1.00e+00	Arhgef16 Ndufb9 Retreg2
Rb content in liver	164.47	3	2	28.6	0	1.00e+00	Arhgef16 Ndufb9 Retreg2
Se content in liver	8.16	2	0	0	0	1.00e+00	Arhgef16 Ndufb9
Sr content in liver	37.52	1	1	14.3	0	1.00e+00	Arhgef16
Zn content in liver	5263.94	3	2	28.6	0	1.00e+00	Arhgef16 Ndufb9 Retreg2

Associations by panel

Tissue	RNA modality	# hits	% hits/tests	Avg chisq
Adipose	alternative polyA	0	0	0.98
Adipose	alternative TSS	0	0	0.9
Adipose	gene expression	1	0	1.03
Adipose	isoform ratio	0	0	0.98
Adipose	intron excision ratio	0	0	0.83
Adipose	mRNA stability	1	0	0.99
BLA	alternative polyA	0	0	1
BLA	alternative TSS	0	0	1.02
BLA	gene expression	0	0	1
BLA	isoform ratio	0	0	0.99
BLA	intron excision ratio	0	0	0.87
BLA	mRNA stability	0	0	1
Brain	alternative polyA	0	0	0.97
Brain	alternative TSS	0	0	1.01
Brain	gene expression	0	0	1
Brain	isoform ratio	0	0	0.99
Brain	intron excision ratio	0	0	0.91
Brain	mRNA stability	0	0	1.02
Eye	alternative polyA	0	0	1.07
Eye	alternative TSS	0	0	1.31
Eye	gene expression	0	0	1.06
Eye	isoform ratio	0	0	1.08
Eye	intron excision ratio	0	0	0.97
Eye	mRNA stability	0	0	1.13
IC	alternative polyA	0	0	1
IC	alternative TSS	0	0	0.97
IC	gene expression	0	0	1.01
IC	isoform ratio	0	0	1.01
IC	intron excision ratio	0	0	0.9
IC	mRNA stability	0	0	1
IL	alternative polyA	0	0	1.04
IL	alternative TSS	0	0	0.86
IL	gene expression	0	0	1
IL	isoform ratio	0	0	0.93
IL	intron excision ratio	0	0	0.82
IL	mRNA stability	0	0	0.93
LHb	alternative polyA	0	0	0.92
LHb	alternative TSS	0	0	0.86
LHb	gene expression	0	0	0.97
LHb	isoform ratio	0	0	0.95
LHb	intron excision ratio	0	0	0.82
LHb	mRNA stability	0	0	0.98
Liver	alternative polyA	0	0	0.96
Liver	alternative TSS	0	0	1.02
Liver	gene expression	1	0	0.98
Liver	isoform ratio	1	0	1
Liver	intron excision ratio	0	0	0.92
Liver	mRNA stability	0	0	0.99
NAcc	alternative polyA	1	0	39.89
NAcc	alternative TSS	0	0	1.02
NAcc	gene expression	0	0	1.01
NAcc	isoform ratio	0	0	1.04
NAcc	intron excision ratio	1	0	0.95
NAcc	mRNA stability	0	0	1.01
OFC	alternative polyA	0	0	0.92
OFC	alternative TSS	0	0	0.96
OFC	gene expression	0	0	1
OFC	isoform ratio	0	0	0.96
OFC	intron excision ratio	0	0	0.82
OFC	mRNA stability	0	0	1.01
PL	alternative polyA	0	0	0.99
PL	alternative TSS	0	0	1.02
PL	gene expression	0	0	0.99
PL	isoform ratio	0	0	1
PL	intron excision ratio	0	0	0.94
PL	mRNA stability	0	0	1.02
pVTA	alternative polyA	0	0	1
pVTA	alternative TSS	0	0	1.05
pVTA	gene expression	1	0	1.04
pVTA	isoform ratio	0	0	1.07
pVTA	intron excision ratio	0	0	0.93
pVTA	mRNA stability	0	0	0.98
RMTg	alternative polyA	0	0	0.93
RMTg	alternative TSS	0	0	0.99
RMTg	gene expression	0	0	0.98
RMTg	isoform ratio	0	0	0.95
RMTg	intron excision ratio	0	0	0.89
RMTg	mRNA stability	0	0	0.98