Extinction: sum of active levers before priming

Sum of active levers on first 2 hours of within-session extinction-prime test

Tags: Behavior · Heroin

2 loci · 2 genes with independent associations · 2 total associated genes

Significant Loci

#	Chr	Start pos	End pos	# assoc genes	# joint models	Best TWAS P	Best GWAS P	Cond GWAS P	Joint genes
1	1	68581504	69974370	1	1	1.27e-09	1.02e-01	5.12e-02	Syt5
2	9	24497174	25018277	1	1	1.42e-07	1.75e-02	1.00e+00	Rims1

Pleiotropic Associations

Trait	Chi² ratio	# genes⁺	# genes⁺⁺	% genes⁺⁺	Corr P	Genes
Body weight	2.58	1	0	0	1e+00	Syt5
Epididymis fat weight	2.21	1	0	0	1e+00	Syt5
Glucose	12.08	1	0	0	1e+00	Syt5
Right kidney weight	2.24	2	0	0	1e+00	Rims1 Syt5
Length without tail	3.25	1	0	0	1e+00	Syt5
Liver weight, left	10.21	1	0	0	1e+00	Syt5
Liver weight, right	7.21	2	0	0	1e+00	Rims1 Syt5
Tibialis anterior weight	2.35	1	0	0	1e+00	Syt5
Tibia length	7.53	1	0	0	1e+00	Syt5
Std. dev. time between licks in bursts	22.72	1	1	50	1e+00	Syt5
Indifference point 0 sec	6.32	1	0	0	1e+00	Syt5
Indifference point function ln k	8.79	1	0	0	1e+00	Syt5
Indifference point function log k	8.79	1	0	0	1e+00	Syt5
Delay discounting total patch changes 0 sec	5.75	1	0	0	1e+00	Syt5
Delay discounting total patch changes 24 sec	10.35	1	0	0	1e+00	Syt5
Delay discounting time to switch 0 sec	55.89	1	1	50	1e+00	Syt5
Delay discounting water rate 0 sec	10.34	1	0	0	1e+00	Syt5
Delay discounting water rate 12 sec	22.12	1	1	50	1e+00	Syt5
Delay discounting water rate 18 sec	19.1	1	0	0	1e+00	Syt5
Delay discounting water rate 24 sec	7.99	1	0	0	1e+00	Syt5
Light reinforcement 1	21.59	1	1	50	1e+00	Syt5
Light reinforcement 2	14.63	2	1	50	1e+00	Rims1 Syt5
Reaction time num false alarms AUC	10.57	1	0	0	1e+00	Syt5
Reaction time mean	5.11	1	0	0	1e+00	Syt5
Reaction time mean AUC	6.17	1	0	0	1e+00	Syt5
Median of all reaction times	6.98	1	0	0	1e+00	Syt5
Reaction time omissions	5.26	1	0	0	1e+00	Syt5
Reaction time false alarm rate	4.67	1	0	0	1e+00	Syt5
Social response proportion	7.98	1	0	0	1e+00	Syt5
Social time	18.13	1	0	0	1e+00	Syt5
Conditioned locomotion	5.89	1	0	0	1e+00	Syt5
Cocaine response after cond. corrected	18.2	1	0	0	1e+00	Syt5
Cocaine response after cond. not corrected	16.42	1	0	0	1e+00	Syt5
Saline control response	13.17	1	0	0	1e+00	Syt5
Condit. Reinf. lever presses	9.91	1	0	0	1e+00	Syt5
Pavlov. Cond. change in total contacts	5.83	1	0	0	1e+00	Syt5
Conditioned reinforcement - actives	22.28	1	0	0	1e+00	Syt5
Conditioned reinforcement - inactives	5.55	1	0	0	1e+00	Rims1
Conditioned locomotion	15.14	1	0	0	1e+00	Syt5
Intermittent access intake day 1-15 change	7.2	1	0	0	1e+00	Syt5
Intermittent access intake escalation 2	5.26	1	0	0	1e+00	Syt5
Intermitt. access day 1 inactive lever presses	17.1	2	0	0	1e+00	Rims1 Syt5
Intermitt. access day 15 inactive lever presses	23.1	2	1	50	1e+00	Rims1 Syt5
Intermitt. access escalation Index	17.22	1	0	0	1e+00	Syt5
Intermittent access total infusions	4.68	1	0	0	1e+00	Rims1
Intermittent access standard deviation	9.35	1	0	0	1e+00	Syt5
Post-drug Anxiety	10.17	1	0	0	1e+00	Syt5
Baseline Anxiety	26.3	1	1	50	1e+00	Syt5
Lifetime Intake	4.54	1	0	0	1e+00	Rims1
Incentive Sensitization - Responses	7.6	2	0	0	1e+00	Rims1 Syt5
Incentive Sensitization - Breakpoint	7.46	2	0	0	1e+00	Rims1 Syt5
Progressive ratio test 1 active lever presses	11.71	1	0	0	1e+00	Rims1
Progressive ratio test 1 breakpoint	14.08	1	0	0	1e+00	Rims1
Progressive ratio test 2 active lever presses	14.22	1	0	0	1e+00	Rims1
Progressive ratio test 2 breakpoint	16.36	1	0	0	1e+00	Rims1
Short access day 1 total inactive lever presses	24.45	1	1	50	1e+00	Syt5
Short access day 10 total inactive lever presses	17.17	2	1	50	1e+00	Rims1 Syt5
Short access total infusions	5.45	1	0	0	1e+00	Rims1
Short access day 10 total locomotion	11.18	1	0	0	1e+00	Syt5
Short access total locomotion	13.05	1	0	0	1e+00	Syt5
One hour access (0.3 mA shock)	4.85	1	0	0	1e+00	Rims1
One hour access (shock baseline)	24.39	1	1	50	1e+00	Syt5
Number of responses in last shaping day	9.84	1	0	0	1e+00	Syt5
Context. condit. distance diff. score	4.29	1	0	0	1e+00	Syt5
Locomotion velocity, session 1	61.51	1	1	50	1e+00	Syt5
Locomotion distance, session 1	22.42	1	1	50	1e+00	Syt5
Locomotion velocity, session 2	20.55	1	0	0	1e+00	Syt5
Locomotion distance, session 2	5.4	1	0	0	1e+00	Syt5
Locomotion velocity, session 3	6.63	1	0	0	1e+00	Rims1
Locomotion distance, session 3	8.71	1	0	0	1e+00	Syt5
Locomotion velocity, session 7	5.99	1	0	0	1e+00	Syt5
Locomotion distance, session 7	10.24	1	0	0	1e+00	Syt5
Locomotion velocity, session 8	15.73	1	0	0	1e+00	Syt5
Locomotion distance, session 8	9.21	1	0	0	1e+00	Syt5
Time in familiar zone, hab. session 1	12.82	1	0	0	1e+00	Syt5
Total zone transitions, hab. session 1	25.53	1	1	50	1e+00	Syt5
Total locomotion distance, hab. session 1	19.26	1	1	50	1e+00	Syt5
Locomotion velocity, hab. session 1	12.27	1	0	0	1e+00	Syt5
Time in familiar zone, hab. session 2	14.1	1	0	0	1e+00	Syt5
Total zone transitions, hab. session 2	7.86	1	0	0	1e+00	Syt5
Total locomotion distance, hab. session 2	10.72	1	0	0	1e+00	Syt5
Locomotion velocity, hab. session 2	13.63	1	0	0	1e+00	Syt5
Total zone transitions, NPP test	4.12	1	0	0	1e+00	Syt5
Pavlov. Cond. magazine entry latency	10.45	1	0	0	1e+00	Syt5
Pavlov. Cond. lever contacts	4.84	1	0	0	1e+00	Syt5
Pavlov. Cond. intertrial magazine entries	19.53	1	0	0	1e+00	Syt5
Pavlov. Cond. response bias	13.37	1	0	0	1e+00	Syt5
Bone: cortical porosity	7.72	1	0	0	1e+00	Syt5
Bone: cortical thickness	3.19	1	0	0	1e+00	Syt5
Bone: elastic displacement	7.66	1	0	0	1e+00	Syt5
Bone: elastic work	5.83	1	0	0	1e+00	Syt5
Bone: post-yield work	11.59	1	0	0	1e+00	Syt5
Bone: stiffness	4.47	1	0	0	1e+00	Syt5
Bone: tissue strength	13.13	1	0	0	1e+00	Syt5
Bone: trabecular tissue density	8.22	1	0	0	1e+00	Syt5
Distance traveled before self-admin	31.68	2	1	50	1e+00	Rims1 Syt5
Distance traveled after self-admin	30.82	2	1	50	1e+00	Rims1 Syt5
Delta time in open arm before/after self-admin	18.04	1	0	0	1e+00	Syt5
Diff in mean of infusions in LGA sessions	20.43	1	0	0	1e+00	Syt5
Active lever presses in extinction session 6	17.94	1	0	0	1e+00	Syt5
Delta distance traveled before/after self-admin	12.16	1	0	0	1e+00	Rims1
Delta ambulatory time before/after self-admin	5.33	1	0	0	1e+00	Rims1
Time in closed arm after self-admin	14.9	2	0	0	1e+00	Rims1 Syt5
Time in open arm after self-admin	17.09	1	0	0	1e+00	Syt5
Sum of active levers in priming session hrs 5-6	17.22	1	0	0	1e+00	Syt5
Time to tail flick, vehicle, before self-admin	9.4	1	0	0	1e+00	Rims1
Time to tail flick, test, before self-admin	57.17	1	1	50	1e+00	Syt5
Time to tail flick, test, after self-admin	5.74	1	0	0	1e+00	Syt5
Delta time to tail flick, vehicle, before/after SA	8.61	1	0	0	1e+00	Syt5
Delta time to tail flick, test, before/after SA	42.42	1	1	50	1e+00	Syt5
Ambulatory time before self-admin	36.65	1	1	50	1e+00	Syt5
Ambulatory time after self-admin	61.31	1	1	50	1e+00	Syt5
Total heroin consumption	5.77	1	0	0	1e+00	Syt5
Delay disc. indifference point, 0s delay	27.96	1	1	50	1e+00	Syt5
Delay disc. indifference point, 16s delay	24.13	1	0	0	1e+00	Syt5
Delay disc. indifference point, 24s delay	9.61	1	0	0	1e+00	Syt5
Change in fecal boli incidents, locomotor task	6.15	1	0	0	1e+00	Syt5
Time >=10cm from walls, locomotor time 1	29.01	1	1	50	1e+00	Rims1
Bouts of movement, locomotor time 1	31.42	2	1	50	1e+00	Rims1 Syt5
Total resting periods, locomotor time 1	22.13	2	1	50	1e+00	Rims1 Syt5
Vertical activity count, locomotor time 1	15.17	2	0	0	1e+00	Rims1 Syt5
Bouts of movement, locomotor time 2	26.45	1	1	50	1e+00	Rims1
Total resting periods, locomotor time 2	30.91	1	1	50	1e+00	Rims1
Rest time, locomotor task time 2	6.81	2	0	0	1e+00	Rims1 Syt5
Vertical activity count, locomotor time 2	5.62	1	0	0	1e+00	Syt5
Weight adjusted by age	8.26	1	0	0	1e+00	Syt5
Seeking ratio, delayed vs. immediate footshock	29.67	1	1	50	1e+00	Syt5
Locomotion in novel chamber	12.66	1	0	0	1e+00	Syt5
Locomotion in novel chamber post-restriction	5.15	1	0	0	1e+00	Rims1
Progressive ratio	7.56	1	0	0	1e+00	Syt5
Food seeking constrained by brief footshock	133.39	1	1	50	1e+00	Syt5
Seeking ratio, punishment vs. effort	16.51	1	0	0	1e+00	Syt5
Run reversals in cocaine runway, females	8.33	1	0	0	1e+00	Syt5
Cd content in liver	7.7	1	0	0	1e+00	Syt5
Co content in liver	19.37	1	0	0	1e+00	Syt5
Rb content in liver	6.49	1	0	0	1e+00	Syt5
Sr content in liver	66.74	1	1	50	1e+00	Syt5
Zn content in liver	12.43	1	0	0	1e+00	Syt5

Associations by panel

Tissue	RNA modality	# hits	Avg chisq
Adipose	alternative polyA	0	0.96
Adipose	alternative TSS	0	1.05
Adipose	gene expression	0	1.02
Adipose	isoform ratio	0	1.02
Adipose	intron excision ratio	0	0.83
Adipose	mRNA stability	0	1.01
BLA	alternative polyA	0	1.13
BLA	alternative TSS	0	1.09
BLA	gene expression	0	1.04
BLA	isoform ratio	0	1.06
BLA	intron excision ratio	0	0.94
BLA	mRNA stability	1	1
Brain	alternative polyA	0	1.07
Brain	alternative TSS	0	1.07
Brain	gene expression	0	1.02
Brain	isoform ratio	0	1.03
Brain	intron excision ratio	0	0.95
Brain	mRNA stability	0	1.01
Eye	alternative polyA	0	1.12
Eye	alternative TSS	0	1.19
Eye	gene expression	0	1.02
Eye	isoform ratio	0	1.14
Eye	intron excision ratio	0	1.01
Eye	mRNA stability	0	1.11
IL	alternative polyA	0	1.13
IL	alternative TSS	0	1.08
IL	gene expression	0	1.03
IL	isoform ratio	0	1
IL	intron excision ratio	0	0.99
IL	mRNA stability	0	1.01
LHb	alternative polyA	0	1.09
LHb	alternative TSS	0	1.3
LHb	gene expression	0	1.02
LHb	isoform ratio	0	1.02
LHb	intron excision ratio	0	0.96
LHb	mRNA stability	0	1.08
Liver	alternative polyA	0	0.96
Liver	alternative TSS	0	1.04
Liver	gene expression	0	1
Liver	isoform ratio	0	1.04
Liver	intron excision ratio	0	0.96
Liver	mRNA stability	0	1.07
NAcc	alternative polyA	0	1.15
NAcc	alternative TSS	0	1.09
NAcc	gene expression	1	1.03
NAcc	isoform ratio	0	1.02
NAcc	intron excision ratio	0	0.95
NAcc	mRNA stability	0	0.97
OFC	alternative polyA	0	0.95
OFC	alternative TSS	0	1.17
OFC	gene expression	0	1.01
OFC	isoform ratio	0	0.99
OFC	intron excision ratio	0	1
OFC	mRNA stability	0	1.02
PL	alternative polyA	0	1.09
PL	alternative TSS	0	1.17
PL	gene expression	0	1.02
PL	isoform ratio	0	1
PL	intron excision ratio	0	0.98
PL	mRNA stability	0	1.01