Hub : Traits

Extinction: sum of active levers before priming

Sum of active levers on first 2 hours of within-session extinction-prime test

Tags: Behavior · Heroin

Project: u01_peter_kalivas

6 loci · 6 genes with independent associations · 6 total associated genes

Significant Loci

#	Chr	Start pos	End pos	# assoc genes	# joint models	Best TWAS P	Best GWAS P	Cond GWAS P	Joint genes
1	chr3	89719707	91113777	1	1	2.97e-08	1.96e-02	3.70e-05	Slc43a3
2	chr7	92127461	93066096	1	1	3.47e-11	8.78e-02	1.00e+00	Ndufb9
3	chr8	41432021	42517271	1	1	2.15e-10	4.10e-01	1.49e-05	Foxred1
4	chr8	117463629	118343328	1	1	1.92e-18	2.43e-02	1.00e+00	Mst1
5	chr9	83390749	84777604	1	1	0.00e+00	3.97e-01	1.00e+00	Retreg2
6	chr17	61510864	62906219	1	1	3.65e-12	2.26e-01	1.49e-02	Ccny

Pleiotropic Associations

Trait	Chi2 ratio	# genes+	# genes++	% genes++	Corr	Corr P	Genes
BMI with tail	294.05	3	2	33.3	0	1.00e+00	Foxred1 Ndufb9 Retreg2
BMI without tail	19087.71	3	2	33.3	0	1.00e+00	Ccny Ndufb9 Retreg2
Body weight	8.94	3	2	33.3	0	1.00e+00	Mst1 Ndufb9 Retreg2
Epididymis fat weight	9080.51	4	3	50	1	1.06e-03	Ccny Mst1 Ndufb9 Retreg2
Glucose	226.07	3	2	33.3	0	1.00e+00	Mst1 Ndufb9 Retreg2
Heart weight	1536.76	2	1	16.7	0	1.00e+00	Ndufb9 Retreg2
Left kidney weight	13765.01	4	2	33.3	-1	2.21e-03	Ccny Foxred1 Ndufb9 Retreg2
Right kidney weight	8088.05	5	4	66.7	-1	2.99e-04	Ccny Foxred1 Mst1 Ndufb9 Retreg2
Tail length	14460.63	2	1	16.7	0	1.00e+00	Mst1 Retreg2
Length with tail	301.86	5	3	50	0.99	9.22e-04	Foxred1 Mst1 Ndufb9 Retreg2 Slc43a3
Length without tail	11815.62	4	2	33.3	-1	7.22e-04	Ccny Mst1 Ndufb9 Retreg2
Liver weight, left	880.75	4	2	33.3	-0.99	6.00e-03	Ccny Mst1 Ndufb9 Retreg2
Liver weight, right	31.51	3	2	33.3	0	1.00e+00	Mst1 Ndufb9 Retreg2
Parametrial fat weight	63.11	3	1	16.7	0	1.00e+00	Foxred1 Retreg2 Slc43a3
Retroperitoneal fat weight	1985.63	2	2	33.3	0	1.00e+00	Mst1 Retreg2
Intraocular pressure	10386.52	1	1	16.7	0	1.00e+00	Retreg2
Extensor digitorum longus weight	541.05	2	1	16.7	0	1.00e+00	Mst1 Retreg2
Soleus weight	9.26	3	1	16.7	0	1.00e+00	Mst1 Ndufb9 Retreg2
Tibialis anterior weight	580.28	2	1	16.7	0	1.00e+00	Mst1 Retreg2
Tibia length	265.42	3	2	33.3	0	1.00e+00	Mst1 Ndufb9 Retreg2
Number of licking bursts	67424.86	1	1	16.7	0	1.00e+00	Retreg2
Food consumed during 24 hour testing period	11843.69	3	1	16.7	0	1.00e+00	Ccny Mst1 Retreg2
Times rat made contact with spout	41.61	2	1	16.7	0	1.00e+00	Ndufb9 Retreg2
Mean time between licks in bursts	55817.09	2	1	16.7	0	1.00e+00	Ndufb9 Retreg2
Mean num. licks in bursts	56750.08	1	1	16.7	0	1.00e+00	Retreg2
Std. dev. time between licks in bursts	14881.26	2	1	16.7	0	1.00e+00	Mst1 Retreg2
Water consumed over 24 hours	11394.32	3	1	16.7	0	1.00e+00	Ccny Mst1 Retreg2
Patch foraging indifference point 0 sec	19591.07	2	1	16.7	0	1.00e+00	Mst1 Retreg2
Patch foraging indifference point AUC	12566.41	4	3	50	-1	6.21e-04	Ccny Mst1 Ndufb9 Retreg2
Indifference point function ln k	13972.7	4	4	66.7	1	7.79e-04	Ccny Mst1 Ndufb9 Retreg2
Indifference point function log k	13972.7	4	4	66.7	1	7.79e-04	Ccny Mst1 Ndufb9 Retreg2
Patch foraging total patch changes 0 sec	20977.37	2	1	16.7	0	1.00e+00	Mst1 Retreg2
Patch foraging total patch changes 12 sec	491.17	5	4	66.7	1	4.11e-04	Ccny Foxred1 Mst1 Ndufb9 Retreg2
Patch foraging total patch changes 18 sec	10122.69	4	2	33.3	1	2.51e-05	Ccny Mst1 Ndufb9 Retreg2
Patch foraging total patch changes 24 sec	18737.98	4	3	50	1	2.66e-04	Ccny Mst1 Ndufb9 Retreg2
Patch foraging total patch changes 6 sec	2607.57	3	2	33.3	0	1.00e+00	Ccny Ndufb9 Retreg2
Patch foraging time to switch 0 sec	22171.85	3	2	33.3	0	1.00e+00	Mst1 Ndufb9 Retreg2
Patch foraging water rate 0 sec	30219.01	2	1	16.7	0	1.00e+00	Ndufb9 Retreg2
Patch foraging water rate 12 sec	23555.93	3	2	33.3	0	1.00e+00	Ccny Mst1 Retreg2
Patch foraging water rate 18 sec	11246.65	3	1	16.7	0	1.00e+00	Mst1 Ndufb9 Retreg2
Patch foraging water rate 24 sec	523.92	2	1	16.7	0	1.00e+00	Mst1 Retreg2
Patch foraging water rate 6 sec	297.7	3	3	50	0	1.00e+00	Ccny Ndufb9 Retreg2
Locomotor activity	17.63	3	1	16.7	0	1.00e+00	Ccny Foxred1 Mst1
Locomotor testing distance	5549.26	5	3	50	-1	4.19e-04	Ccny Foxred1 Mst1 Ndufb9 Retreg2
Locomotor testing rearing	15860.24	4	2	33.3	-1	2.30e-03	Foxred1 Mst1 Ndufb9 Retreg2
Light reinforcement 1	22114.5	3	2	33.3	0	1.00e+00	Ccny Mst1 Retreg2
Light reinforcement 2	9210.73	4	3	50	-1	2.50e-03	Ccny Mst1 Ndufb9 Retreg2
Reaction time number correct	21165.65	3	2	33.3	0	1.00e+00	Ccny Ndufb9 Retreg2
Reaction time mean minus median	39986.09	3	1	16.7	0	1.00e+00	Mst1 Ndufb9 Retreg2
Reaction time mean minus median AUC	41341.25	3	3	50	0	1.00e+00	Mst1 Ndufb9 Retreg2
Reaction time num false alarms	7685.9	2	1	16.7	0	1.00e+00	Mst1 Retreg2
Reaction time num false alarms AUC	17513.8	2	1	16.7	0	1.00e+00	Mst1 Retreg2
Reaction time trials correct on left	21165.65	3	2	33.3	0	1.00e+00	Ccny Ndufb9 Retreg2
Reaction time trials on left	20303.42	3	2	33.3	0	1.00e+00	Ccny Ndufb9 Retreg2
Reaction time mean	29724.21	1	1	16.7	0	1.00e+00	Retreg2
Reaction time mean AUC	38768	1	1	16.7	0	1.00e+00	Retreg2
Median of all reaction times	7893.84	1	1	16.7	0	1.00e+00	Retreg2
Reaction time omissions	2792.39	3	1	16.7	0	1.00e+00	Mst1 Ndufb9 Retreg2
Reaction time false alarm rate	76.38	3	1	16.7	0	1.00e+00	Mst1 Ndufb9 Retreg2
Reaction time premature initiation rate	4870.68	2	1	16.7	0	1.00e+00	Retreg2 Slc43a3
Reaction time premature initiations	53743.58	1	1	16.7	0	1.00e+00	Retreg2
Std. dev. reaction times	20293.6	3	1	16.7	0	1.00e+00	Mst1 Ndufb9 Retreg2
Reaction time trials completed	20303.42	3	2	33.3	0	1.00e+00	Ccny Ndufb9 Retreg2
Reaction time trials AUC	20718.27	3	1	16.7	0	1.00e+00	Ccny Ndufb9 Retreg2
Social response proportion	4397.95	2	1	16.7	0	1.00e+00	Mst1 Retreg2
Social responses	323.05	4	1	16.7	-1	1.40e-03	Ccny Mst1 Ndufb9 Retreg2
Social time	5828.31	2	1	16.7	0	1.00e+00	Mst1 Retreg2
Conditioned locomotion	1400.08	1	1	16.7	0	1.00e+00	Retreg2
Cocaine response after cond. corrected	19128.47	1	1	16.7	0	1.00e+00	Retreg2
Cocaine response after cond. not corrected	18571.31	1	1	16.7	0	1.00e+00	Retreg2
Cocaine response before conditioning	655.41	1	1	16.7	0	1.00e+00	Retreg2
Saline control response	1639.18	2	2	33.3	0	1.00e+00	Mst1 Retreg2
Condit. Reinf. active minus inactive responses	7271.32	2	2	33.3	0	1.00e+00	Mst1 Retreg2
Condit. Reinf. active-inactive response ratio	14360.59	2	1	16.7	0	1.00e+00	Ndufb9 Retreg2
Condit. Reinf. active responses	1165.18	2	2	33.3	0	1.00e+00	Mst1 Retreg2
Condit. Reinf. inactive responses	5466.41	2	2	33.3	0	1.00e+00	Mst1 Retreg2
Condit. Reinf. lever presses	1311.07	3	2	33.3	0	1.00e+00	Mst1 Ndufb9 Retreg2
Condit. Reinf. lever reinforcers received	243.91	2	1	16.7	0	1.00e+00	Mst1 Retreg2
Pavlov. Cond. lever latency	1278.33	2	2	33.3	0	1.00e+00	Mst1 Retreg2
Pavlov. Cond. magazine entry latency	6738.25	2	2	33.3	0	1.00e+00	Mst1 Retreg2
Pavlov. Cond. change in total contacts	19909.31	2	1	16.7	0	1.00e+00	Ndufb9 Retreg2
Pavlov. Cond. index score	6407.33	2	2	33.3	0	1.00e+00	Mst1 Retreg2
Pavlov. Cond. latency score	8109.24	2	2	33.3	0	1.00e+00	Mst1 Retreg2
Pavlov. Cond. lever contacts	2689.72	2	2	33.3	0	1.00e+00	Mst1 Retreg2
Pavlov. Cond. magazine entry number	2097.69	2	2	33.3	0	1.00e+00	Mst1 Retreg2
Pavlov. Cond. intertrial magazine entries	17558.57	2	2	33.3	0	1.00e+00	Mst1 Retreg2
Pavlov. Cond. lever-magazine prob. diff.	5938.34	2	2	33.3	0	1.00e+00	Mst1 Retreg2
Pavlov. Cond. response bias	641.31	2	2	33.3	0	1.00e+00	Mst1 Retreg2
Conditioned reinforcement - actives	33617.26	3	2	33.3	0	1.00e+00	Ccny Ndufb9 Retreg2
Conditioned reinforcement - inactives	13015.1	5	3	50	1	1.84e-04	Ccny Foxred1 Mst1 Ndufb9 Retreg2
Conditioned locomotion	2087.93	5	2	33.3	0.99	1.59e-03	Ccny Foxred1 Mst1 Ndufb9 Retreg2
Intermittent access intake day 1-15 change	25587.55	5	3	50	1	5.09e-05	Ccny Foxred1 Mst1 Retreg2 Slc43a3
Intermittent access intake escalation	31542.88	4	3	50	1	8.05e-04	Foxred1 Mst1 Retreg2 Slc43a3
Intermittent access intake escalation 2	9081.79	4	3	50	1	8.64e-04	Ccny Foxred1 Mst1 Retreg2
Intermitt. access day 1 inactive lever presses	36140.12	5	2	33.3	1	1.27e-06	Ccny Mst1 Ndufb9 Retreg2 Slc43a3
Intermitt. access day 15 inactive lever presses	30945.18	4	3	50	1	2.53e-03	Foxred1 Ndufb9 Retreg2 Slc43a3
Intermitt. access escalation Index	23355.95	4	2	33.3	-1	4.41e-05	Mst1 Ndufb9 Retreg2 Slc43a3
Intermittent access day 1 total infusions	22043.83	3	1	16.7	0	1.00e+00	Foxred1 Mst1 Retreg2
Intermittent access day 15 total infusions	16266.34	3	2	33.3	0	1.00e+00	Foxred1 Retreg2 Slc43a3
Intermittent access terminal intake (last 3 days)	8285.37	3	2	33.3	0	1.00e+00	Foxred1 Retreg2 Slc43a3
Intermittent access total infusions	51.55	4	1	16.7	-0.92	7.56e-02	Ccny Foxred1 Retreg2 Slc43a3
Intermittent access day 1 locomotion	11660.83	3	1	16.7	0	1.00e+00	Ccny Foxred1 Retreg2
Intermittent access day 15 total locomotion	42786.58	2	2	33.3	0	1.00e+00	Ccny Retreg2
Intermittent access total locomotion	37.15	4	1	16.7	0.84	1.63e-01	Mst1 Ndufb9 Retreg2 Slc43a3
Intermittent access standard deviation	22804.45	5	3	50	1	1.23e-04	Ccny Foxred1 Mst1 Retreg2 Slc43a3
Cocaine induced anxiety	17301	4	2	33.3	-0.99	5.01e-03	Ccny Foxred1 Ndufb9 Retreg2
Post-drug Anxiety	1595.89	3	2	33.3	0	1.00e+00	Mst1 Ndufb9 Retreg2
Baseline Anxiety	8433.93	4	2	33.3	0.99	9.39e-03	Ccny Foxred1 Ndufb9 Retreg2
Lifetime Intake	422.66	4	1	16.7	-0.98	1.66e-02	Ccny Foxred1 Retreg2 Slc43a3
Incentive Sensitization - Responses	17850.36	4	2	33.3	-1	2.41e-04	Ccny Ndufb9 Retreg2 Slc43a3
Incentive Sensitization - Breakpoint	11064.62	5	2	33.3	-1	1.77e-04	Ccny Foxred1 Ndufb9 Retreg2 Slc43a3
Progressive ratio test 1 active lever presses	10671	3	1	16.7	0	1.00e+00	Ccny Ndufb9 Retreg2
Progressive ratio test 1 breakpoint	10109.49	3	1	16.7	0	1.00e+00	Ccny Ndufb9 Retreg2
Progressive ratio test 1 inactive lever presses	15570.04	4	3	50	1	2.23e-03	Foxred1 Mst1 Ndufb9 Retreg2
Progressive ratio test 2 active lever presses	5096.01	3	1	16.7	0	1.00e+00	Ccny Ndufb9 Retreg2
Progressive ratio test 2 breakpoint	4281.49	2	1	16.7	0	1.00e+00	Ccny Retreg2
Progressive ratio test 2 inactive lever presses	14506.31	5	1	16.7	1	1.54e-04	Ccny Foxred1 Mst1 Ndufb9 Retreg2
Total sessions with >9 infusions	510.69	4	3	50	-0.97	2.77e-02	Ccny Mst1 Retreg2 Slc43a3
Short access day 1 total inactive lever presses	7910.87	5	3	50	-1	3.85e-04	Ccny Foxred1 Mst1 Ndufb9 Retreg2
Short access day 10 total inactive lever presses	46316.52	3	3	50	0	1.00e+00	Ccny Mst1 Retreg2
Short access day 1 total infusions	7697.21	5	2	33.3	-1	3.88e-04	Ccny Foxred1 Mst1 Retreg2 Slc43a3
Short access day 10 total infusions	7585.44	3	3	50	0	1.00e+00	Mst1 Ndufb9 Retreg2
Short access total infusions	4403.04	2	2	33.3	0	1.00e+00	Ccny Retreg2
Short access day 1 locomotion	4148.68	6	2	33.3	0.99	7.61e-05	Ccny Foxred1 Mst1 Ndufb9 Retreg2 Slc43a3
Short access day 10 total locomotion	22057.89	4	2	33.3	1	3.37e-03	Foxred1 Mst1 Retreg2 Slc43a3
Short access total locomotion	3752.33	5	3	50	0.99	5.42e-04	Foxred1 Mst1 Ndufb9 Retreg2 Slc43a3
Compulsive drug intake	4682.6	4	2	33.3	-0.99	6.38e-03	Foxred1 Mst1 Ndufb9 Retreg2
One hour access (0.3 mA shock)	601.94	4	2	33.3	1	9.90e-04	Ccny Foxred1 Ndufb9 Retreg2
One hour access (shock baseline)	27501.97	2	1	16.7	0	1.00e+00	Foxred1 Retreg2
Number of responses in last shaping day	3414.8	4	1	16.7	1	4.81e-04	Ccny Foxred1 Mst1 Retreg2
Context. condit. distance diff. score	212.47	1	1	16.7	0	1.00e+00	Retreg2
Locomotion velocity, session 1	1769.63	2	1	16.7	0	1.00e+00	Ndufb9 Retreg2
Locomotion distance, session 1	516.6	2	1	16.7	0	1.00e+00	Ccny Retreg2
Locomotion velocity, session 2	1110.36	2	2	33.3	0	1.00e+00	Mst1 Retreg2
Locomotion distance, session 2	174.93	3	1	16.7	0	1.00e+00	Ccny Mst1 Retreg2
Locomotion velocity, session 3	507.49	1	1	16.7	0	1.00e+00	Retreg2
Locomotion distance, session 3	4009.46	1	1	16.7	0	1.00e+00	Retreg2
Stereotopy head waving bouts, day 3	691.91	2	1	16.7	0	1.00e+00	Mst1 Retreg2
Stereotopy head waving duration, day 3	1446.08	2	1	16.7	0	1.00e+00	Mst1 Retreg2
Locomotion velocity, session 7	210.64	2	2	33.3	0	1.00e+00	Mst1 Retreg2
Locomotion distance, session 7	342.68	3	2	33.3	0	1.00e+00	Mst1 Ndufb9 Retreg2
Stereotopy head waving bouts, day 7	1279.33	2	2	33.3	0	1.00e+00	Ndufb9 Retreg2
Stereotopy head waving duration, day 7	1081.37	2	2	33.3	0	1.00e+00	Ndufb9 Retreg2
Locomotion velocity, session 8	409.23	1	1	16.7	0	1.00e+00	Retreg2
Locomotion distance, session 8	147.88	1	1	16.7	0	1.00e+00	Retreg2
Degree of sensitization distance	1889.61	2	2	33.3	0	1.00e+00	Mst1 Retreg2
Degree of sensitization stereotypy	690.43	3	1	16.7	0	1.00e+00	Mst1 Ndufb9 Retreg2
Condit. Reinf. active minus inactive responses	957.65	1	1	16.7	0	1.00e+00	Retreg2
Condit. Reinf. active-inactive response ratio	242.03	1	1	16.7	0	1.00e+00	Retreg2
Condit. Reinf. active responses	2765.7	1	1	16.7	0	1.00e+00	Retreg2
Condit. Reinf. inactive responses	1569.87	3	1	16.7	0	1.00e+00	Mst1 Ndufb9 Retreg2
Incentive salience index mean	1780.77	2	1	16.7	0	1.00e+00	Mst1 Retreg2
Condit. Reinf. lever presses	2666.81	2	2	33.3	0	1.00e+00	Mst1 Retreg2
Time in familiar zone, hab. session 1	5593.23	2	1	16.7	0	1.00e+00	Mst1 Retreg2
Time in novel zone, hab. session 1	4629.95	2	2	33.3	0	1.00e+00	Mst1 Retreg2
Total zone transitions, hab. session 1	221.7	2	1	16.7	0	1.00e+00	Ndufb9 Retreg2
Total locomotion distance, hab. session 1	394.1	1	1	16.7	0	1.00e+00	Retreg2
Locomotion velocity, hab. session 1	266.96	1	1	16.7	0	1.00e+00	Retreg2
Time in familiar zone, hab. session 2	2966.16	2	2	33.3	0	1.00e+00	Mst1 Retreg2
Time in novel zone, hab. session 2	3208.33	2	2	33.3	0	1.00e+00	Mst1 Retreg2
Total zone transitions, hab. session 2	28.15	3	1	16.7	0	1.00e+00	Mst1 Ndufb9 Retreg2
Total locomotion distance, hab. session 2	14.23	2	1	16.7	0	1.00e+00	Mst1 Retreg2
Locomotion velocity, hab. session 2	31.27	1	1	16.7	0	1.00e+00	Retreg2
Novel to familiar place preference ratio	7678.6	2	1	16.7	0	1.00e+00	Mst1 Retreg2
Novelty place preference	7474.7	2	1	16.7	0	1.00e+00	Mst1 Retreg2
Time in novel zone, NPP test	5350.34	2	1	16.7	0	1.00e+00	Mst1 Retreg2
Total zone transitions, NPP test	980.79	2	2	33.3	0	1.00e+00	Ndufb9 Retreg2
Total locomotion distance, NPP test	1687.31	1	1	16.7	0	1.00e+00	Retreg2
Locomotion velocity, NPP test	479.14	2	1	16.7	0	1.00e+00	Ccny Retreg2
Pavlov. Cond. lever latency	276.98	2	2	33.3	0	1.00e+00	Mst1 Retreg2
Pavlov. Cond. change in total contacts	522.83	2	1	16.7	0	1.00e+00	Mst1 Retreg2
Pavlov. Cond. index score	214.07	2	2	33.3	0	1.00e+00	Mst1 Retreg2
Pavlov. Cond. latency score	224.45	2	2	33.3	0	1.00e+00	Mst1 Retreg2
Pavlov. Cond. lever contacts	252.4	3	2	33.3	0	1.00e+00	Mst1 Ndufb9 Retreg2
Pavlov. Cond. magazine entry number	250.94	2	1	16.7	0	1.00e+00	Mst1 Retreg2
Pavlov. Cond. intertrial magazine entries	60.1	3	2	33.3	0	1.00e+00	Mst1 Ndufb9 Retreg2
Pavlov. Cond. lever-magazine prob. diff.	223.77	2	2	33.3	0	1.00e+00	Mst1 Retreg2
Pavlov. Cond. response bias	303.26	2	2	33.3	0	1.00e+00	Mst1 Retreg2
Bone: apparent density	2735.95	2	1	16.7	0	1.00e+00	Ndufb9 Retreg2
Bone surface	3109.3	2	2	33.3	0	1.00e+00	Mst1 Retreg2
Bone volume	4317.38	2	1	16.7	0	1.00e+00	Mst1 Retreg2
Bone: connectivity density	564.06	3	1	16.7	0	1.00e+00	Mst1 Ndufb9 Retreg2
Bone: cortical apparent density	6014.36	2	1	16.7	0	1.00e+00	Ndufb9 Retreg2
Bone: cortical area	1559.21	3	2	33.3	0	1.00e+00	Mst1 Ndufb9 Retreg2
Bone: cortical porosity	150.35	3	1	16.7	0	1.00e+00	Mst1 Ndufb9 Retreg2
Bone: cortical porosity	560.57	2	1	16.7	0	1.00e+00	Ndufb9 Retreg2
Bone: cortical thickness	157.6	3	2	33.3	0	1.00e+00	Mst1 Ndufb9 Retreg2
Bone: cortical thickness	996.09	3	2	33.3	0	1.00e+00	Mst1 Ndufb9 Retreg2
Bone: cortical tissue density	6505.97	2	1	16.7	0	1.00e+00	Ndufb9 Retreg2
Bone: elastic displacement	7604.03	1	1	16.7	0	1.00e+00	Retreg2
Bone: elastic work	195.81	2	2	33.3	0	1.00e+00	Mst1 Retreg2
Bone: endosteal estimation	2975.35	3	1	16.7	0	1.00e+00	Mst1 Ndufb9 Retreg2
Bone: endosteal perimeter	5936.33	2	1	16.7	0	1.00e+00	Mst1 Retreg2
Bone: final force	840.18	2	2	33.3	0	1.00e+00	Mst1 Retreg2
Bone: final moment	146.88	2	2	33.3	0	1.00e+00	Mst1 Retreg2
Bone: marrow area	3148.45	3	1	16.7	0	1.00e+00	Mst1 Ndufb9 Retreg2
Bone: maximum diameter	2046.98	3	2	33.3	0	1.00e+00	Mst1 Ndufb9 Retreg2
Bone: maximum force	4390.32	2	2	33.3	0	1.00e+00	Mst1 Retreg2
Bone: maximum moment	3034.59	2	2	33.3	0	1.00e+00	Mst1 Retreg2
Bone: minimum diameter	2061.38	2	2	33.3	0	1.00e+00	Mst1 Retreg2
Bone: periosteal estimation	4919.52	2	2	33.3	0	1.00e+00	Mst1 Retreg2
Bone: periosteal perimeter	5722.93	2	2	33.3	0	1.00e+00	Mst1 Retreg2
Bone: post-yield work	6843.13	2	1	16.7	0	1.00e+00	Mst1 Retreg2
Bone: stiffness	4554.23	2	2	33.3	0	1.00e+00	Mst1 Retreg2
Bone: tissue strength	2995.95	1	1	16.7	0	1.00e+00	Retreg2
Bone: trabecular number	5387.39	2	2	33.3	0	1.00e+00	Ndufb9 Retreg2
Bone: trabecular spacing	2669.39	3	3	50	0	1.00e+00	Mst1 Ndufb9 Retreg2
Bone: trabecular thickness	4257.4	2	2	33.3	0	1.00e+00	Mst1 Retreg2
Bone: trabecular tissue density	4866.8	3	3	50	0	1.00e+00	Mst1 Ndufb9 Retreg2
Breakpoint value in progressive ratio session	18809.48	2	1	16.7	0	1.00e+00	Mst1 Retreg2
Distance traveled before self-admin	12642.89	4	1	16.7	1	3.81e-03	Ccny Foxred1 Ndufb9 Retreg2
Distance traveled after self-admin	10837.46	3	2	33.3	0	1.00e+00	Ccny Foxred1 Retreg2
Delta time in closed arm before/after self-admin	84.66	5	2	33.3	0.79	1.14e-01	Ccny Foxred1 Mst1 Ndufb9 Retreg2
Delta time in open arm before/after self-admin	5049.67	3	1	16.7	0	1.00e+00	Ccny Mst1 Retreg2
Diff in mean of infusions in LGA sessions	12226.72	3	2	33.3	0	1.00e+00	Mst1 Ndufb9 Retreg2
Active lever presses in extinction session 6	207.86	4	3	50	-0.98	1.63e-02	Ccny Foxred1 Mst1 Retreg2
Delta distance traveled before/after self-admin	749.61	4	2	33.3	-0.98	1.85e-02	Ccny Foxred1 Ndufb9 Retreg2
Delta ambulatory time before/after self-admin	7721.14	4	1	16.7	-1	4.55e-03	Ccny Foxred1 Ndufb9 Retreg2
Time in closed arm before self-admin	5387.08	5	2	33.3	-1	1.92e-05	Ccny Foxred1 Mst1 Retreg2 Slc43a3
Time in closed arm after self-admin	1570.76	3	3	50	0	1.00e+00	Ccny Mst1 Retreg2
Time in open arm before self-admin	2213.9	4	3	50	-0.99	8.99e-03	Ccny Mst1 Ndufb9 Retreg2
Time in open arm after self-admin	123.34	5	3	50	0.86	6.19e-02	Ccny Foxred1 Mst1 Ndufb9 Retreg2
Sum of active levers in priming session hrs 5-6	345.13	3	2	33.3	0	1.00e+00	Ndufb9 Retreg2 Slc43a3
Time to tail flick, vehicle, before self-admin	2255.21	6	3	50	1	1.94e-06	Ccny Foxred1 Mst1 Ndufb9 Retreg2 Slc43a3
Time to tail flick, vehicle, after self-admin	10545.19	4	1	16.7	1	1.97e-03	Ccny Foxred1 Ndufb9 Retreg2
Time to tail flick, test, before self-admin	2051.27	4	2	33.3	-0.99	8.03e-03	Foxred1 Mst1 Ndufb9 Retreg2
Time to tail flick, test, after self-admin	378.11	4	2	33.3	0.95	4.88e-02	Ccny Foxred1 Ndufb9 Retreg2
Delta time to tail flick, vehicle, before/after SA	3305.45	3	3	50	0	1.00e+00	Ccny Mst1 Retreg2
Delta time to tail flick, test, before/after SA	5236.1	3	1	16.7	0	1.00e+00	Mst1 Ndufb9 Retreg2
Ambulatory time before self-admin	26306.39	3	2	33.3	0	1.00e+00	Ccny Foxred1 Retreg2
Ambulatory time after self-admin	8880.01	3	1	16.7	0	1.00e+00	Ccny Mst1 Retreg2
Total heroin consumption	98.05	3	3	50	0	1.00e+00	Ccny Foxred1 Retreg2
Area under the delay curve	24791.27	1	1	16.7	0	1.00e+00	Retreg2
Delay disc. indifference point, 0s delay	2159.25	1	1	16.7	0	1.00e+00	Retreg2
Delay disc. indifference point, 16s delay	10986.22	2	1	16.7	0	1.00e+00	Ccny Retreg2
Delay disc. indifference point, 2s delay	155.27	1	1	16.7	0	1.00e+00	Retreg2
Delay disc. indifference point, 24s delay	10820.5	3	1	16.7	0	1.00e+00	Ccny Retreg2 Slc43a3
Delay disc. indifference point, 4s delay	162.94	4	1	16.7	-1	1.09e-03	Ccny Mst1 Ndufb9 Retreg2
Delay disc. indifference point, 8s delay	33362.4	1	1	16.7	0	1.00e+00	Retreg2
Delay discount exponential model param	16922.54	1	1	16.7	0	1.00e+00	Retreg2
Delay discount hyperbolic model param	12277.65	1	1	16.7	0	1.00e+00	Retreg2
Fecal boli incidents, locomotor time 1	61202.36	1	1	16.7	0	1.00e+00	Retreg2
Change in fecal boli incidents, locomotor task	1914.03	3	3	50	0	1.00e+00	Ccny Ndufb9 Retreg2
Time >=10cm from walls, locomotor time 1	4342.59	3	1	16.7	0	1.00e+00	Ccny Ndufb9 Retreg2
Bouts of movement, locomotor time 1	5409.06	2	2	33.3	0	1.00e+00	Ccny Retreg2
Total resting periods, locomotor time 1	1407.78	2	1	16.7	0	1.00e+00	Ccny Retreg2
Rest time, locomotor task time 1	7458.8	3	1	16.7	0	1.00e+00	Ndufb9 Retreg2 Slc43a3
Distance moved, locomotor task time 1	17224.84	4	2	33.3	-1	8.16e-04	Ccny Ndufb9 Retreg2 Slc43a3
Vertical activity count, locomotor time 1	142354.07	1	1	16.7	0	1.00e+00	Retreg2
Time >=10cm from walls, locomotor time 2	35582.77	2	1	16.7	0	1.00e+00	Ccny Retreg2
Bouts of movement, locomotor time 2	20516.45	4	2	33.3	1	2.25e-03	Ccny Foxred1 Retreg2 Slc43a3
Total resting periods, locomotor time 2	24768.91	4	2	33.3	1	2.26e-03	Ccny Foxred1 Retreg2 Slc43a3
Rest time, locomotor task time 2	8508.39	3	1	16.7	0	1.00e+00	Ndufb9 Retreg2 Slc43a3
Distance moved, locomotor task time 2	4250.65	2	2	33.3	0	1.00e+00	Ccny Retreg2
Vertical activity count, locomotor time 2	26786.04	2	1	16.7	0	1.00e+00	Ccny Retreg2
Weight adjusted by age	23619.48	3	3	50	0	1.00e+00	Ccny Ndufb9 Retreg2
Seeking ratio, delayed vs. immediate footshock	6729.38	2	1	16.7	0	1.00e+00	Ccny Retreg2
Locomotion in novel chamber	1330.8	3	2	33.3	0	1.00e+00	Ccny Ndufb9 Retreg2
Locomotion in novel chamber post-restriction	21812.22	3	1	16.7	0	1.00e+00	Ndufb9 Retreg2 Slc43a3
Progressive ratio	22651.13	3	3	50	0	1.00e+00	Ccny Ndufb9 Retreg2
Food seeking constrained by brief footshock	941.83	2	1	16.7	0	1.00e+00	Ndufb9 Retreg2
Seeking ratio, punishment vs. effort	20653.58	2	2	33.3	0	1.00e+00	Ndufb9 Retreg2
Run reversals in cocaine runway, females	4710.65	2	1	16.7	0	1.00e+00	Foxred1 Retreg2
Run reversals in cocaine runway, males	2594.62	3	2	33.3	0	1.00e+00	Foxred1 Ndufb9 Retreg2
Latency to leave start box in cocaine runway	8153.9	2	1	16.7	0	1.00e+00	Ccny Retreg2
Latency to leave start box in cocaine runway, F	3596.44	2	2	33.3	0	1.00e+00	Ndufb9 Retreg2
Latency to leave start box in cocaine runway, M	447.3	4	2	33.3	-0.99	7.35e-03	Ccny Foxred1 Ndufb9 Retreg2
Co content in liver	1133.25	1	1	16.7	0	1.00e+00	Retreg2
Cu content in liver	28.08	2	1	16.7	0	1.00e+00	Ndufb9 Retreg2
Fe content in liver	1344.53	1	1	16.7	0	1.00e+00	Retreg2
K content in liver	1519.62	1	1	16.7	0	1.00e+00	Retreg2
Mg content in liver	6026.97	1	1	16.7	0	1.00e+00	Retreg2
Mn content in liver	537.3	2	2	33.3	0	1.00e+00	Ndufb9 Retreg2
Na content in liver	2013.84	2	1	16.7	0	1.00e+00	Ndufb9 Retreg2
Rb content in liver	71.08	2	2	33.3	0	1.00e+00	Ndufb9 Retreg2
Se content in liver	8.63	1	0	0	0	1.00e+00	Ndufb9
Zn content in liver	1887.46	2	2	33.3	0	1.00e+00	Ndufb9 Retreg2

Associations by panel

Tissue	RNA modality	# hits	% hits/tests	Avg chisq
Adipose	alternative polyA	0	0	0.98
Adipose	alternative TSS	0	0	0.9
Adipose	gene expression	1	0	1.04
Adipose	isoform ratio	0	0	0.98
Adipose	intron excision ratio	0	0	0.83
Adipose	mRNA stability	1	0	0.99
BLA	alternative polyA	0	0	0.99
BLA	alternative TSS	0	0	1.01
BLA	gene expression	0	0	1
BLA	isoform ratio	0	0	0.99
BLA	intron excision ratio	0	0	0.87
BLA	mRNA stability	0	0	0.99
Brain	alternative polyA	0	0	0.97
Brain	alternative TSS	0	0	1.01
Brain	gene expression	0	0	1
Brain	isoform ratio	0	0	0.99
Brain	intron excision ratio	0	0	0.91
Brain	mRNA stability	0	0	1.02
Eye	alternative polyA	0	0	1.08
Eye	alternative TSS	0	0	1.32
Eye	gene expression	0	0	1.06
Eye	isoform ratio	0	0	1.08
Eye	intron excision ratio	0	0	0.97
Eye	mRNA stability	0	0	1.13
IC	alternative polyA	0	0	1
IC	alternative TSS	0	0	0.96
IC	gene expression	0	0	1.01
IC	isoform ratio	0	0	1.01
IC	intron excision ratio	0	0	0.91
IC	mRNA stability	0	0	1
IL	alternative polyA	0	0	1.04
IL	alternative TSS	0	0	0.85
IL	gene expression	0	0	1
IL	isoform ratio	0	0	0.92
IL	intron excision ratio	0	0	0.83
IL	mRNA stability	0	0	0.93
LHb	alternative polyA	0	0	0.92
LHb	alternative TSS	0	0	0.87
LHb	gene expression	0	0	0.97
LHb	isoform ratio	0	0	0.95
LHb	intron excision ratio	0	0	0.82
LHb	mRNA stability	0	0	0.99
Liver	alternative polyA	0	0	0.96
Liver	alternative TSS	0	0	1.02
Liver	gene expression	0	0	0.98
Liver	isoform ratio	1	0	1.01
Liver	intron excision ratio	0	0	0.92
Liver	mRNA stability	0	0	0.98
NAcc	alternative polyA	1	0	9.89
NAcc	alternative TSS	0	0	1.02
NAcc	gene expression	0	0	1.01
NAcc	isoform ratio	0	0	1.04
NAcc	intron excision ratio	1	0	0.95
NAcc	mRNA stability	0	0	1
OFC	alternative polyA	0	0	0.92
OFC	alternative TSS	0	0	0.95
OFC	gene expression	0	0	1
OFC	isoform ratio	0	0	0.96
OFC	intron excision ratio	0	0	0.83
OFC	mRNA stability	0	0	1.01
PL	alternative polyA	0	0	0.99
PL	alternative TSS	0	0	1.02
PL	gene expression	0	0	0.99
PL	isoform ratio	0	0	1
PL	intron excision ratio	0	0	0.94
PL	mRNA stability	0	0	1.02
pVTA	alternative polyA	0	0	1
pVTA	alternative TSS	0	0	1.05
pVTA	gene expression	1	0	1.01
pVTA	isoform ratio	0	0	1.07
pVTA	intron excision ratio	0	0	0.93
pVTA	mRNA stability	0	0	0.99
RMTg	alternative polyA	0	0	0.95
RMTg	alternative TSS	0	0	1.03
RMTg	gene expression	0	0	0.98
RMTg	isoform ratio	0	0	0.92
RMTg	intron excision ratio	0	0	0.88
RMTg	mRNA stability	0	0	0.95