Extinction: sum of active levers before priming

Sum of active levers on first 2 hours of within-session extinction-prime test

Tags: Behavior · Heroin

2 loci · 2 genes with independent associations · 2 total associated genes

Significant Loci

#	Chr	Start pos	End pos	# assoc genes	# joint models	Best TWAS P	Best GWAS P	Cond GWAS P	Joint genes
1	chr3	153329192	154718613	1	1	2.65e-08	1.07e-02	4.45e-04	Slc35c2
2	chr4	10085840	10964652	1	1	6.01e-14	6.97e-02	1.00e+00	Abcb8

Pleiotropic Associations

Trait	Chi² ratio	# genes⁺	# genes⁺⁺	% genes⁺⁺	Corr P	Genes
BMI with tail	2.61	1	0	0	1e+00	Abcb8
BMI without tail	2.45	1	0	0	1e+00	Abcb8
Right kidney weight	1.88	1	0	0	1e+00	Abcb8
Length without tail	2.32	1	0	0	1e+00	Abcb8
Parametrial fat weight	14.02	1	1	50	1e+00	Slc35c2
Food consumed during 24 hour testing period	4.57	1	0	0	1e+00	Abcb8
Patch foraging indifference point 0 sec	6.28	1	0	0	1e+00	Abcb8
Patch foraging total patch changes 0 sec	6.05	1	0	0	1e+00	Abcb8
Patch foraging total patch changes 12 sec	4.78	1	0	0	1e+00	Slc35c2
Patch foraging total patch changes 6 sec	4.53	2	0	0	1e+00	Abcb8 Slc35c2
Patch foraging water rate 12 sec	7.82	1	0	0	1e+00	Abcb8
Light reinforcement 2	9.1	1	0	0	1e+00	Slc35c2
Reaction time num false alarms	4.36	1	0	0	1e+00	Abcb8
Reaction time omissions	9.77	2	0	0	1e+00	Abcb8 Slc35c2
Reaction time premature initiations	5.75	1	0	0	1e+00	Abcb8
Cocaine response after cond. corrected	4.68	1	0	0	1e+00	Abcb8
Conditioned reinforcement - actives	10.78	1	0	0	1e+00	Abcb8
Conditioned locomotion	7.04	1	0	0	1e+00	Slc35c2
Intermittent access intake day 1-15 change	18.47	1	0	0	1e+00	Slc35c2
Intermittent access intake escalation	7.85	1	0	0	1e+00	Slc35c2
Intermittent access intake escalation 2	20.96	1	0	0	1e+00	Abcb8
Intermittent access day 1 locomotion	5.26	1	0	0	1e+00	Slc35c2
Intermittent access day 15 total locomotion	5.77	1	0	0	1e+00	Slc35c2
Intermittent access total locomotion	6.41	2	0	0	1e+00	Abcb8 Slc35c2
Cocaine induced anxiety	7.96	1	0	0	1e+00	Abcb8
Baseline Anxiety	11.67	1	0	0	1e+00	Abcb8
Incentive Sensitization - Responses	11.93	1	0	0	1e+00	Abcb8
Incentive Sensitization - Breakpoint	11.74	1	0	0	1e+00	Abcb8
Short access day 1 total inactive lever presses	23.74	1	0	0	1e+00	Abcb8
Short access day 10 total inactive lever presses	5	2	0	0	1e+00	Abcb8 Slc35c2
Short access day 10 total infusions	8.23	1	0	0	1e+00	Abcb8
Short access day 1 locomotion	14.94	1	0	0	1e+00	Abcb8
Short access day 10 total locomotion	6.24	1	0	0	1e+00	Abcb8
Compulsive drug intake	14.15	1	0	0	1e+00	Abcb8
Number of responses in last shaping day	11.75	1	0	0	1e+00	Abcb8
Stereotopy head waving duration, day 7	4.21	1	0	0	1e+00	Abcb8
Condit. Reinf. active minus inactive responses	16.72	1	0	0	1e+00	Abcb8
Condit. Reinf. active-inactive response ratio	8.58	1	0	0	1e+00	Abcb8
Condit. Reinf. active responses	16.06	1	0	0	1e+00	Abcb8
Incentive salience index mean	13.29	1	0	0	1e+00	Abcb8
Condit. Reinf. lever presses	4.61	1	0	0	1e+00	Abcb8
Time in novel zone, hab. session 1	8.85	1	0	0	1e+00	Abcb8
Locomotion velocity, NPP test	4.03	1	0	0	1e+00	Slc35c2
Pavlov. Cond. intertrial magazine entries	5.02	1	0	0	1e+00	Abcb8
Bone: apparent density	4.12	1	0	0	1e+00	Abcb8
Bone volume	3.86	1	0	0	1e+00	Abcb8
Bone: connectivity density	3.27	1	0	0	1e+00	Abcb8
Bone: cortical area	6.52	2	0	0	1e+00	Abcb8 Slc35c2
Bone: cortical thickness	7.54	2	0	0	1e+00	Abcb8 Slc35c2
Bone: maximum diameter	3.67	1	0	0	1e+00	Abcb8
Bone: periosteal perimeter	3.51	1	0	0	1e+00	Abcb8
Bone: trabecular number	6.09	1	0	0	1e+00	Abcb8
Bone: trabecular thickness	5.88	1	0	0	1e+00	Abcb8
Distance traveled before self-admin	10.05	2	0	0	1e+00	Abcb8 Slc35c2
Distance traveled after self-admin	9.45	2	0	0	1e+00	Abcb8 Slc35c2
Delta time in open arm before/after self-admin	9.79	1	0	0	1e+00	Abcb8
Active lever presses in extinction session 6	6.45	1	0	0	1e+00	Abcb8
Delta distance traveled before/after self-admin	6.32	1	0	0	1e+00	Abcb8
Delta ambulatory time before/after self-admin	4.98	1	0	0	1e+00	Abcb8
Time in closed arm before self-admin	18.14	2	0	0	1e+00	Abcb8 Slc35c2
Time in closed arm after self-admin	34.42	1	1	50	1e+00	Abcb8
Time in open arm before self-admin	27.11	1	1	50	1e+00	Slc35c2
Time in open arm after self-admin	20.17	2	1	50	1e+00	Abcb8 Slc35c2
Sum of active levers in priming session hrs 5-6	35.31	1	1	50	1e+00	Abcb8
Time to tail flick, vehicle, before self-admin	10.56	2	0	0	1e+00	Abcb8 Slc35c2
Time to tail flick, vehicle, after self-admin	8.93	1	0	0	1e+00	Abcb8
Time to tail flick, test, after self-admin	13.81	1	0	0	1e+00	Abcb8
Delta time to tail flick, vehicle, before/after SA	25.19	2	1	50	1e+00	Abcb8 Slc35c2
Delta time to tail flick, test, before/after SA	23.62	1	0	0	1e+00	Abcb8
Ambulatory time before self-admin	10.39	2	0	0	1e+00	Abcb8 Slc35c2
Ambulatory time after self-admin	13.83	2	0	0	1e+00	Abcb8 Slc35c2
Delay disc. indifference point, 16s delay	12.72	1	0	0	1e+00	Slc35c2
Delay disc. indifference point, 4s delay	22.33	1	0	0	1e+00	Abcb8
Fecal boli incidents, locomotor time 1	13.14	1	0	0	1e+00	Slc35c2
Bouts of movement, locomotor time 1	19.6	1	0	0	1e+00	Abcb8
Total resting periods, locomotor time 1	13.99	1	0	0	1e+00	Abcb8
Vertical activity count, locomotor time 1	6.85	1	0	0	1e+00	Abcb8
Bouts of movement, locomotor time 2	12.99	2	0	0	1e+00	Abcb8 Slc35c2
Total resting periods, locomotor time 2	13.58	2	0	0	1e+00	Abcb8 Slc35c2
Rest time, locomotor task time 2	7.29	1	0	0	1e+00	Slc35c2
Distance moved, locomotor task time 2	7.44	2	0	0	1e+00	Abcb8 Slc35c2
Vertical activity count, locomotor time 2	4.78	1	0	0	1e+00	Abcb8
Weight adjusted by age	5.54	1	0	0	1e+00	Abcb8
Locomotion in novel chamber	11.46	1	0	0	1e+00	Abcb8
Food seeking constrained by brief footshock	19.3	1	0	0	1e+00	Abcb8
Run reversals in cocaine runway, females	18.55	1	0	0	1e+00	Abcb8
K content in liver	5.2	1	0	0	1e+00	Abcb8

Associations by panel

Tissue	RNA modality	# hits	Avg chisq
Adipose	alternative polyA	0	0.98
Adipose	alternative TSS	0	0.99
Adipose	gene expression	0	1.02
Adipose	isoform ratio	0	0.97
Adipose	intron excision ratio	0	0.84
Adipose	mRNA stability	0	1.01
BLA	alternative polyA	0	1.03
BLA	alternative TSS	0	0.96
BLA	gene expression	0	1.03
BLA	isoform ratio	0	1.03
BLA	intron excision ratio	0	0.92
BLA	mRNA stability	0	0.98
Brain	alternative polyA	0	1
Brain	alternative TSS	0	1.03
Brain	gene expression	0	1.02
Brain	isoform ratio	0	1.01
Brain	intron excision ratio	0	0.95
Brain	mRNA stability	0	1.01
Eye	alternative polyA	0	1.15
Eye	alternative TSS	0	1.15
Eye	gene expression	0	1.04
Eye	isoform ratio	0	1.1
Eye	intron excision ratio	0	0.94
Eye	mRNA stability	0	0.84
IL	alternative polyA	0	1.06
IL	alternative TSS	0	1.03
IL	gene expression	0	1
IL	isoform ratio	0	1.11
IL	intron excision ratio	0	0.91
IL	mRNA stability	0	1
LHb	alternative polyA	0	1.01
LHb	alternative TSS	0	1.1
LHb	gene expression	0	0.98
LHb	isoform ratio	0	1
LHb	intron excision ratio	0	0.88
LHb	mRNA stability	0	1
Liver	alternative polyA	1	0.94
Liver	alternative TSS	0	1.06
Liver	gene expression	0	0.97
Liver	isoform ratio	0	0.99
Liver	intron excision ratio	0	0.91
Liver	mRNA stability	0	1.03
NAcc	alternative polyA	0	1.03
NAcc	alternative TSS	0	1.01
NAcc	gene expression	0	1.02
NAcc	isoform ratio	0	1.04
NAcc	intron excision ratio	0	0.96
NAcc	mRNA stability	0	0.99
OFC	alternative polyA	0	1.03
OFC	alternative TSS	0	1.07
OFC	gene expression	0	1
OFC	isoform ratio	0	1.02
OFC	intron excision ratio	0	0.87
OFC	mRNA stability	0	1
PL	alternative polyA	0	0.96
PL	alternative TSS	0	1.02
PL	gene expression	0	1
PL	isoform ratio	0	1.04
PL	intron excision ratio	0	1
PL	mRNA stability	0	0.99
pVTA	alternative polyA	0	1.03
pVTA	alternative TSS	0	1.03
pVTA	gene expression	0	1.01
pVTA	isoform ratio	0	1.03
pVTA	intron excision ratio	1	0.92
pVTA	mRNA stability	0	0.98
RMTg	alternative polyA	0	1.29
RMTg	alternative TSS	0	0.87
RMTg	gene expression	0	0.99
RMTg	isoform ratio	0	1.11
RMTg	intron excision ratio	0	0.95
RMTg	mRNA stability	0	1.01