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Time to tail flick, test, after self-admin

Time in sec to remove tail from noxious stimuli under test conditions in the second tail flick after self admin

Tags: Behavior · Heroin

Project: u01_peter_kalivas

2 significantly associated models · 1 unique gene

Significant Loci

# chr p0 p1 # assoc genes # joint models best TWAS P best SNP P cond SNP P % var exp joint genes
1 10 24428451 25820407 1 1 9.9e-11 0.041 6.2e-06 -387 Mat2b

p0: physical position of the start of the locus. p1: physical position of the end of the locus. # joint models: number of models selected by step-wise conditional analysis.

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
BMI with tail 2.9 1 0 0 0 1 Mat2b
BMI without tail 4.3 1 0 0 0 1 Mat2b
Length with tail 3.2 1 0 0 0 1 Mat2b
Length without tail 4.9 1 0 0 0 1 Mat2b
Parametrial fat weight 2.9 1 0 0 0 1 Mat2b
Intraocular pressure 5.9 1 0 0 0 1 Mat2b
Delay discounting water rate 0 sec 3.6 1 0 0 0 1 Mat2b
Delay discounting water rate 6 sec 5.7 1 0 0 0 1 Mat2b
Reaction time number correct 6.2 1 0 0 0 1 Mat2b
Reaction time num false alarms 8.3 1 0 0 0 1 Mat2b
Reaction time num false alarms AUC 7.8 1 0 0 0 1 Mat2b
Reaction time trials correct on left 6.2 1 0 0 0 1 Mat2b
Reaction time trials on left 7.2 1 0 0 0 1 Mat2b
Reaction time omissions 16.6 1 0 0 0 1 Mat2b
Reaction time trials completed 7.2 1 0 0 0 1 Mat2b
Reaction time trials AUC 7.6 1 0 0 0 1 Mat2b
Conditioned reinforcement - actives 9.3 1 0 0 0 1 Mat2b
Conditioned locomotion 6.3 1 0 0 0 1 Mat2b
Intermittent access intake day 1-15 change 21.2 1 0 0 0 1 Mat2b
Intermittent access intake escalation 5.4 1 0 0 0 1 Mat2b
Intermittent access intake escalation 2 15.6 1 0 0 0 1 Mat2b
Intermitt. access day 15 inactive lever presses 7.6 1 0 0 0 1 Mat2b
Intermitt. access escalation Index 10.0 1 0 0 0 1 Mat2b
Intermittent access day 15 total locomotion 4.8 1 0 0 0 1 Mat2b
Intermittent access standard deviation 19.3 1 0 0 0 1 Mat2b
Cocaine induced anxiety 6.5 1 0 0 0 1 Mat2b
Post-drug Anxiety 13.1 1 0 0 0 1 Mat2b
Compulsive drug intake 5.2 1 0 0 0 1 Mat2b
One hour access (shock baseline) 6.7 1 0 0 0 1 Mat2b
Locomotion velocity, session 3 5.2 1 0 0 0 1 Mat2b
Total zone transitions, hab. session 2 5.2 1 0 0 0 1 Mat2b
Total locomotion distance, hab. session 2 4.7 1 0 0 0 1 Mat2b
Locomotion velocity, hab. session 2 4.9 1 0 0 0 1 Mat2b
Total zone transitions, NPP test 3.7 1 0 0 0 1 Mat2b
Total locomotion distance, NPP test 3.8 1 0 0 0 1 Mat2b
Locomotion velocity, NPP test 3.7 1 0 0 0 1 Mat2b
Breakpoint value in progressive ratio session 4.7 1 0 0 0 1 Mat2b
Delta time in closed arm before/after self-admin 5.4 1 0 0 0 1 Mat2b
Delta time in open arm before/after self-admin 8.1 1 0 0 0 1 Mat2b
Diff in mean of infusions in LGA sessions 5.0 1 0 0 0 1 Mat2b
Time in closed arm after self-admin 6.4 1 0 0 0 1 Mat2b
Time in open arm after self-admin 4.7 1 0 0 0 1 Mat2b
Sum of active levers in priming session hrs 5-6 7.7 1 0 0 0 1 Mat2b
Delta time to tail flick, test, before/after SA 6.1 1 0 0 0 1 Mat2b
Total heroin consumption 7.6 1 0 0 0 1 Mat2b
Area under the delay curve 8.0 1 0 0 0 1 Mat2b
Delay disc. indifference point, 0s delay 10.7 1 0 0 0 1 Mat2b
Delay disc. indifference point, 16s delay 5.9 1 0 0 0 1 Mat2b
Delay discount exponential model param 6.9 1 0 0 0 1 Mat2b
Delay discount hyperbolic model param 6.5 1 0 0 0 1 Mat2b
Time >=10cm from walls, locomotor time 1 6.5 1 0 0 0 1 Mat2b
Bouts of movement, locomotor time 1 5.2 1 0 0 0 1 Mat2b
Run reversals in cocaine runway, males 9.1 1 0 0 0 1 Mat2b

chisq ratio: Average Chi2 statistic for the selected genes in the secondary trait, divided by the average statistic for all genes in the secondary trait. # genes+: Shared significant genes at Bonferroni correction. # genes++: Shared significant genes at transcriptome-wide significance. % genes++: Number of [++] genes as a percentage of primary trait’s total joint genes. corr: Correlation of effect sizes across the [+] genes.

Associations by panel

tissue modality # hits % hits/tests avg chisq
Adipose alternative polyA 0 0.000 1.03
Adipose alternative TSS 0 0.000 1.19
Adipose gene expression 0 0.000 1.04
Adipose isoform ratio 0 0.000 1.08
Adipose intron excision ratio 0 0.000 1.07
Adipose mRNA stability 0 0.000 1.00
BLA alternative polyA 0 0.000 1.04
BLA alternative TSS 0 0.000 1.05
BLA gene expression 0 0.000 1.02
BLA isoform ratio 0 0.000 1.04
BLA intron excision ratio 0 0.000 1.07
BLA mRNA stability 0 0.000 0.99
Brain alternative polyA 0 0.000 1.03
Brain alternative TSS 0 0.000 0.97
Brain gene expression 0 0.000 1.02
Brain isoform ratio 0 0.000 0.99
Brain intron excision ratio 0 0.000 1.07
Brain mRNA stability 0 0.000 1.00
Eye alternative polyA 0 0.000 1.10
Eye alternative TSS 0 0.000 1.07
Eye gene expression 0 0.000 0.95
Eye isoform ratio 0 0.000 0.95
Eye intron excision ratio 0 0.000 1.01
Eye mRNA stability 0 0.000 0.94
IL alternative polyA 0 0.000 1.03
IL alternative TSS 0 0.000 0.93
IL gene expression 0 0.000 0.99
IL isoform ratio 0 0.000 1.01
IL intron excision ratio 0 0.000 1.09
IL mRNA stability 0 0.000 1.01
LHb alternative polyA 0 0.000 0.94
LHb alternative TSS 0 0.000 0.92
LHb gene expression 0 0.000 1.03
LHb isoform ratio 0 0.000 0.94
LHb intron excision ratio 0 0.000 1.19
LHb mRNA stability 0 0.000 1.06
Liver alternative polyA 0 0.000 1.07
Liver alternative TSS 0 0.000 0.99
Liver gene expression 0 0.000 1.06
Liver isoform ratio 0 0.000 1.01
Liver intron excision ratio 2 0.046 1.08
Liver mRNA stability 0 0.000 1.02
NAcc alternative polyA 0 0.000 1.02
NAcc alternative TSS 0 0.000 0.94
NAcc gene expression 0 0.000 0.98
NAcc isoform ratio 0 0.000 0.95
NAcc intron excision ratio 0 0.000 1.20
NAcc mRNA stability 0 0.000 1.01
OFC alternative polyA 0 0.000 0.90
OFC alternative TSS 0 0.000 1.12
OFC gene expression 0 0.000 0.97
OFC isoform ratio 0 0.000 1.03
OFC intron excision ratio 0 0.000 1.12
OFC mRNA stability 0 0.000 1.01
PL alternative polyA 0 0.000 1.04
PL alternative TSS 0 0.000 1.05
PL gene expression 0 0.000 0.98
PL isoform ratio 0 0.000 1.00
PL intron excision ratio 0 0.000 1.12
PL mRNA stability 0 0.000 0.97

avg chisq: Average Chi2 (squared Z-score) across all models in this panel for this trait.