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Time to tail flick, test, after self-admin

Time in sec to remove tail from noxious stimuli under test conditions in the second tail flick after self admin

Tags: Behavior · Heroin

Project: u01_peter_kalivas

1 locus · 1 gene with independent associations · 2 total associated genes

Significant Loci

#	Chr	Start pos	End pos	# assoc genes	# joint models	Best TWAS P	Best GWAS P	Cond GWAS P	Joint genes
1	chr10	24428451	25820407	2	1	1.48e-10	4.05e-02	7.31e-05	Mat2b

Pleiotropic Associations

Trait	Chi2 ratio	# genes+	# genes++	% genes++	Corr	Corr P	Genes
BMI with tail	2.93	1	0	0	0	1e+00	Mat2b
BMI without tail	4.21	1	0	0	0	1e+00	Mat2b
Epididymis fat weight	2.19	1	0	0	0	1e+00	Mat2b
Length with tail	2.87	1	0	0	0	1e+00	Mat2b
Length without tail	4.18	1	0	0	0	1e+00	Mat2b
Parametrial fat weight	3.12	1	0	0	0	1e+00	Mat2b
Intraocular pressure	5.74	1	0	0	0	1e+00	Mat2b
Patch foraging water rate 0 sec	3.66	1	0	0	0	1e+00	Mat2b
Patch foraging water rate 6 sec	5.89	1	0	0	0	1e+00	Mat2b
Reaction time number correct	5.05	1	0	0	0	1e+00	Mat2b
Reaction time num false alarms	8.81	1	0	0	0	1e+00	Mat2b
Reaction time num false alarms AUC	8.39	1	0	0	0	1e+00	Mat2b
Reaction time trials correct on left	5.05	1	0	0	0	1e+00	Mat2b
Reaction time trials on left	5.94	1	0	0	0	1e+00	Mat2b
Reaction time omissions	17	1	0	0	0	1e+00	Mat2b
Reaction time trials completed	5.94	1	0	0	0	1e+00	Mat2b
Reaction time trials AUC	6.24	1	0	0	0	1e+00	Mat2b
Conditioned reinforcement - actives	8.45	1	0	0	0	1e+00	Mat2b
Conditioned locomotion	5.89	1	0	0	0	1e+00	Mat2b
Intermittent access intake day 1-15 change	22.32	1	0	0	0	1e+00	Mat2b
Intermittent access intake escalation	5.75	1	0	0	0	1e+00	Mat2b
Intermittent access intake escalation 2	16.14	1	0	0	0	1e+00	Mat2b
Intermitt. access day 15 inactive lever presses	6.77	1	0	0	0	1e+00	Mat2b
Intermitt. access escalation Index	9.85	1	0	0	0	1e+00	Mat2b
Intermittent access day 15 total locomotion	5.03	1	0	0	0	1e+00	Mat2b
Intermittent access standard deviation	20.47	1	0	0	0	1e+00	Mat2b
Cocaine induced anxiety	6.28	1	0	0	0	1e+00	Mat2b
Post-drug Anxiety	13.05	1	0	0	0	1e+00	Mat2b
Compulsive drug intake	5.78	1	0	0	0	1e+00	Mat2b
One hour access (shock baseline)	6.77	1	0	0	0	1e+00	Mat2b
Locomotion velocity, session 3	5.46	1	0	0	0	1e+00	Mat2b
Total zone transitions, hab. session 2	5.57	1	0	0	0	1e+00	Mat2b
Total locomotion distance, hab. session 2	5.14	1	0	0	0	1e+00	Mat2b
Locomotion velocity, hab. session 2	5.46	1	0	0	0	1e+00	Mat2b
Total zone transitions, NPP test	4.15	1	0	0	0	1e+00	Mat2b
Total locomotion distance, NPP test	4.27	1	0	0	0	1e+00	Mat2b
Locomotion velocity, NPP test	4.22	1	0	0	0	1e+00	Mat2b
Breakpoint value in progressive ratio session	4.68	1	0	0	0	1e+00	Mat2b
Delta time in closed arm before/after self-admin	5.79	1	0	0	0	1e+00	Mat2b
Delta time in open arm before/after self-admin	7.7	1	0	0	0	1e+00	Mat2b
Diff in mean of infusions in LGA sessions	5.4	1	0	0	0	1e+00	Mat2b
Time in closed arm after self-admin	7.33	1	0	0	0	1e+00	Mat2b
Time in open arm after self-admin	4.57	1	0	0	0	1e+00	Mat2b
Sum of active levers in priming session hrs 5-6	8.75	1	0	0	0	1e+00	Mat2b
Time to tail flick, test, before self-admin	5.33	1	0	0	0	1e+00	Mat2b
Delta time to tail flick, test, before/after SA	5.61	1	0	0	0	1e+00	Mat2b
Total heroin consumption	7.86	1	0	0	0	1e+00	Mat2b
Area under the delay curve	8.22	1	0	0	0	1e+00	Mat2b
Delay disc. indifference point, 0s delay	11.42	1	0	0	0	1e+00	Mat2b
Delay disc. indifference point, 16s delay	6.05	1	0	0	0	1e+00	Mat2b
Delay discount exponential model param	7.02	1	0	0	0	1e+00	Mat2b
Delay discount hyperbolic model param	6.47	1	0	0	0	1e+00	Mat2b
Time >=10cm from walls, locomotor time 1	6.68	1	0	0	0	1e+00	Mat2b
Bouts of movement, locomotor time 1	5.3	1	0	0	0	1e+00	Mat2b
Run reversals in cocaine runway, males	10.19	1	0	0	0	1e+00	Mat2b
Mn content in liver	4.5	1	0	0	0	1e+00	Mat2b

Associations by panel

Tissue	RNA modality	# hits	% hits/tests	Avg chisq
Adipose	alternative polyA	0	0	1.04
Adipose	alternative TSS	0	0	1.09
Adipose	gene expression	0	0	1.04
Adipose	isoform ratio	0	0	1.06
Adipose	intron excision ratio	0	0	1.1
Adipose	mRNA stability	0	0	1.01
BLA	alternative polyA	0	0	0.98
BLA	alternative TSS	0	0	0.99
BLA	gene expression	0	0	1.04
BLA	isoform ratio	0	0	1.05
BLA	intron excision ratio	0	0	1.06
BLA	mRNA stability	0	0	1.04
Brain	alternative polyA	0	0	1.03
Brain	alternative TSS	0	0	0.94
Brain	gene expression	0	0	1.02
Brain	isoform ratio	0	0	0.98
Brain	intron excision ratio	0	0	1.05
Brain	mRNA stability	0	0	1.01
Eye	alternative polyA	0	0	0.73
Eye	alternative TSS	0	0	0.94
Eye	gene expression	0	0	1.02
Eye	isoform ratio	0	0	0.9
Eye	intron excision ratio	0	0	1.05
Eye	mRNA stability	0	0	1.01
IL	alternative polyA	0	0	1.04
IL	alternative TSS	0	0	0.89
IL	gene expression	0	0	0.96
IL	isoform ratio	0	0	1.04
IL	intron excision ratio	0	0	1.12
IL	mRNA stability	0	0	1.06
LHb	alternative polyA	0	0	0.94
LHb	alternative TSS	0	0	1.15
LHb	gene expression	0	0	1.03
LHb	isoform ratio	0	0	1.04
LHb	intron excision ratio	0	0	1.17
LHb	mRNA stability	0	0	1.02
Liver	alternative polyA	0	0	1.02
Liver	alternative TSS	0	0	1.04
Liver	gene expression	0	0	1.05
Liver	isoform ratio	0	0	1.06
Liver	intron excision ratio	2	0	1.11
Liver	mRNA stability	0	0	1.04
NAcc	alternative polyA	0	0	1
NAcc	alternative TSS	0	0	1.02
NAcc	gene expression	0	0	1
NAcc	isoform ratio	0	0	1.05
NAcc	intron excision ratio	0	0	1.12
NAcc	mRNA stability	0	0	1.02
OFC	alternative polyA	0	0	1.04
OFC	alternative TSS	0	0	0.97
OFC	gene expression	0	0	0.99
OFC	isoform ratio	0	0	1.05
OFC	intron excision ratio	0	0	1.13
OFC	mRNA stability	0	0	1.07
PL	alternative polyA	0	0	1.01
PL	alternative TSS	0	0	1
PL	gene expression	0	0	0.99
PL	isoform ratio	0	0	1.04
PL	intron excision ratio	0	0	1.11
PL	mRNA stability	0	0	1
pVTA	alternative polyA	0	0	1.07
pVTA	alternative TSS	0	0	0.96
pVTA	gene expression	0	0	1.03
pVTA	isoform ratio	0	0	1.08
pVTA	intron excision ratio	0	0	1.24
pVTA	mRNA stability	0	0	1.08
RMTg	alternative polyA	0	0	1.24
RMTg	alternative TSS	0	0	1.05
RMTg	gene expression	0	0	1.03
RMTg	isoform ratio	0	0	0.99
RMTg	intron excision ratio	0	0	1.07
RMTg	mRNA stability	0	0	1.05