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Time to tail flick, test, after self-admin

Time in sec to remove tail from noxious stimuli under test conditions in the second tail flick after self admin

Tags: Behavior · Heroin

Project: u01_peter_kalivas

1 loci · 1 genes with independent associations · 1 total associated genes

Significant Loci

#	Chr	Start pos	End pos	# assoc genes	# joint models	Best TWAS P	Best GWAS P	Cond GWAS P	Joint genes
1	10	24428451	25820407	1	1	9.94e-11	4.05e-02	6.17e-06	Mat2b

Pleiotropic Associations

Trait	Chi2 ratio	# genes+	# genes++	% genes++	Corr	Corr P	Genes
BMI with tail	2.93	1	0	0	0	1e+00	Mat2b
BMI without tail	4.33	1	0	0	0	1e+00	Mat2b
Length with tail	3.19	1	0	0	0	1e+00	Mat2b
Length without tail	4.91	1	0	0	0	1e+00	Mat2b
Parametrial fat weight	2.94	1	0	0	0	1e+00	Mat2b
Intraocular pressure	5.91	1	0	0	0	1e+00	Mat2b
Delay discounting water rate 0 sec	3.64	1	0	0	0	1e+00	Mat2b
Delay discounting water rate 6 sec	5.73	1	0	0	0	1e+00	Mat2b
Reaction time number correct	6.22	1	0	0	0	1e+00	Mat2b
Reaction time num false alarms	8.26	1	0	0	0	1e+00	Mat2b
Reaction time num false alarms AUC	7.83	1	0	0	0	1e+00	Mat2b
Reaction time trials correct on left	6.22	1	0	0	0	1e+00	Mat2b
Reaction time trials on left	7.21	1	0	0	0	1e+00	Mat2b
Reaction time omissions	16.62	1	0	0	0	1e+00	Mat2b
Reaction time trials completed	7.21	1	0	0	0	1e+00	Mat2b
Reaction time trials AUC	7.56	1	0	0	0	1e+00	Mat2b
Conditioned reinforcement - actives	9.35	1	0	0	0	1e+00	Mat2b
Conditioned locomotion	6.34	1	0	0	0	1e+00	Mat2b
Intermittent access intake day 1-15 change	21.2	1	0	0	0	1e+00	Mat2b
Intermittent access intake escalation	5.4	1	0	0	0	1e+00	Mat2b
Intermittent access intake escalation 2	15.6	1	0	0	0	1e+00	Mat2b
Intermitt. access day 15 inactive lever presses	7.64	1	0	0	0	1e+00	Mat2b
Intermitt. access escalation Index	9.99	1	0	0	0	1e+00	Mat2b
Intermittent access day 15 total locomotion	4.8	1	0	0	0	1e+00	Mat2b
Intermittent access standard deviation	19.32	1	0	0	0	1e+00	Mat2b
Cocaine induced anxiety	6.51	1	0	0	0	1e+00	Mat2b
Post-drug Anxiety	13.07	1	0	0	0	1e+00	Mat2b
Compulsive drug intake	5.22	1	0	0	0	1e+00	Mat2b
One hour access (shock baseline)	6.71	1	0	0	0	1e+00	Mat2b
Locomotion velocity, session 3	5.18	1	0	0	0	1e+00	Mat2b
Total zone transitions, hab. session 2	5.2	1	0	0	0	1e+00	Mat2b
Total locomotion distance, hab. session 2	4.65	1	0	0	0	1e+00	Mat2b
Locomotion velocity, hab. session 2	4.91	1	0	0	0	1e+00	Mat2b
Total zone transitions, NPP test	3.66	1	0	0	0	1e+00	Mat2b
Total locomotion distance, NPP test	3.84	1	0	0	0	1e+00	Mat2b
Locomotion velocity, NPP test	3.66	1	0	0	0	1e+00	Mat2b
Breakpoint value in progressive ratio session	4.67	1	0	0	0	1e+00	Mat2b
Delta time in closed arm before/after self-admin	5.36	1	0	0	0	1e+00	Mat2b
Delta time in open arm before/after self-admin	8.07	1	0	0	0	1e+00	Mat2b
Diff in mean of infusions in LGA sessions	4.99	1	0	0	0	1e+00	Mat2b
Time in closed arm after self-admin	6.4	1	0	0	0	1e+00	Mat2b
Time in open arm after self-admin	4.71	1	0	0	0	1e+00	Mat2b
Sum of active levers in priming session hrs 5-6	7.68	1	0	0	0	1e+00	Mat2b
Delta time to tail flick, test, before/after SA	6.08	1	0	0	0	1e+00	Mat2b
Total heroin consumption	7.63	1	0	0	0	1e+00	Mat2b
Area under the delay curve	7.99	1	0	0	0	1e+00	Mat2b
Delay disc. indifference point, 0s delay	10.66	1	0	0	0	1e+00	Mat2b
Delay disc. indifference point, 16s delay	5.86	1	0	0	0	1e+00	Mat2b
Delay discount exponential model param	6.9	1	0	0	0	1e+00	Mat2b
Delay discount hyperbolic model param	6.47	1	0	0	0	1e+00	Mat2b
Time >=10cm from walls, locomotor time 1	6.53	1	0	0	0	1e+00	Mat2b
Bouts of movement, locomotor time 1	5.2	1	0	0	0	1e+00	Mat2b
Run reversals in cocaine runway, males	9.11	1	0	0	0	1e+00	Mat2b

Associations by panel

Tissue	RNA modality	# hits	% hits/tests	Avg chisq
Adipose	alternative polyA	0	0	1.03
Adipose	alternative TSS	0	0	1.19
Adipose	gene expression	0	0	1.04
Adipose	isoform ratio	0	0	1.08
Adipose	intron excision ratio	0	0	1.07
Adipose	mRNA stability	0	0	1
BLA	alternative polyA	0	0	1.04
BLA	alternative TSS	0	0	1.05
BLA	gene expression	0	0	1.02
BLA	isoform ratio	0	0	1.04
BLA	intron excision ratio	0	0	1.07
BLA	mRNA stability	0	0	0.99
Brain	alternative polyA	0	0	1.03
Brain	alternative TSS	0	0	0.97
Brain	gene expression	0	0	1.02
Brain	isoform ratio	0	0	0.99
Brain	intron excision ratio	0	0	1.07
Brain	mRNA stability	0	0	1
Eye	alternative polyA	0	0	1.1
Eye	alternative TSS	0	0	1.07
Eye	gene expression	0	0	0.95
Eye	isoform ratio	0	0	0.95
Eye	intron excision ratio	0	0	1.01
Eye	mRNA stability	0	0	0.94
IL	alternative polyA	0	0	1.03
IL	alternative TSS	0	0	0.93
IL	gene expression	0	0	0.99
IL	isoform ratio	0	0	1.01
IL	intron excision ratio	0	0	1.09
IL	mRNA stability	0	0	1.01
LHb	alternative polyA	0	0	0.94
LHb	alternative TSS	0	0	0.92
LHb	gene expression	0	0	1.03
LHb	isoform ratio	0	0	0.94
LHb	intron excision ratio	0	0	1.19
LHb	mRNA stability	0	0	1.06
Liver	alternative polyA	0	0	1.07
Liver	alternative TSS	0	0	0.99
Liver	gene expression	0	0	1.06
Liver	isoform ratio	0	0	1.01
Liver	intron excision ratio	2	0	1.08
Liver	mRNA stability	0	0	1.02
NAcc	alternative polyA	0	0	1.02
NAcc	alternative TSS	0	0	0.94
NAcc	gene expression	0	0	0.98
NAcc	isoform ratio	0	0	0.95
NAcc	intron excision ratio	0	0	1.2
NAcc	mRNA stability	0	0	1.01
OFC	alternative polyA	0	0	0.9
OFC	alternative TSS	0	0	1.12
OFC	gene expression	0	0	0.97
OFC	isoform ratio	0	0	1.03
OFC	intron excision ratio	0	0	1.12
OFC	mRNA stability	0	0	1.01
PL	alternative polyA	0	0	1.04
PL	alternative TSS	0	0	1.05
PL	gene expression	0	0	0.98
PL	isoform ratio	0	0	1
PL	intron excision ratio	0	0	1.12
PL	mRNA stability	0	0	0.97