Hub : Genes

Pgm2l1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 pVTA gene expression Pgm2l1 0.09 0.07 4.8e-05 0.01 0.04 0.05 0.03 2.0e-02 5.1e-04 1.3e-04 2.0e-03
2 BLA gene expression Pgm2l1 0.45 0.16 0.0e+00 0.28 0.35 0.36 0.37 3.6e-15 3.0e-19 4.7e-20 1.5e-20
3 Adipose gene expression Pgm2l1 0.14 0.09 3.0e-09 0.07 0.06 0.04 0.07 3.6e-08 8.9e-07 1.2e-05 5.9e-08
4 NAcc gene expression Pgm2l1 0.31 0.15 0.0e+00 0.18 0.17 0.18 0.17 3.8e-26 9.5e-26 6.9e-26 1.1e-25
5 Brain gene expression Pgm2l1 0.58 0.17 0.0e+00 0.35 0.52 0.52 0.52 1.4e-33 2.2e-55 1.7e-55 1.9e-55
6 IC gene expression Pgm2l1 0.52 0.13 0.0e+00 0.22 0.42 0.41 0.41 9.2e-10 8.1e-19 1.4e-18 1.9e-18
7 PL gene expression Pgm2l1 0.31 0.14 0.0e+00 0.28 0.34 0.33 0.33 1.5e-30 1.1e-37 1.4e-36 2.0e-37
8 OFC gene expression Pgm2l1 0.58 0.17 2.4e-12 0.33 0.33 0.34 0.34 1.1e-08 1.6e-08 9.1e-09 6.4e-09
9 IL gene expression Pgm2l1 0.66 0.17 1.0e-10 0.16 0.17 0.18 0.18 9.8e-05 7.3e-05 5.0e-05 4.2e-05
10 Adipose mRNA stability Pgm2l1 0.03 0.03 6.7e-03 0.01 0 0 0 1.6e-02 2.1e-01 1.5e-01 1.0e-01

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10
Bone: apparent density0.20.31.10.50.40.90.80.30.30.2-0.2-0.2-1.0
Area under the delay curve0.10.10.20.40.00.10.10.10.10.30.40.40.3
BMI with tail0.41.34.50.00.4-0.7-0.90.70.40.71.81.82.1
BMI without tail0.61.98.0-0.8-0.3-1.7-1.8-0.0-0.30.11.51.52.8
Body weight0.52.410.3-0.30.1-1.5-1.50.50.20.72.02.03.2
Weight adjusted by age0.10.20.80.1-0.4-0.6-0.6-0.2-0.2-0.00.30.30.9
Bone surface0.51.01.4-1.2-1.1-1.1-1.1-1.1-1.0-1.0-0.8-0.80.6
Bone volume0.20.40.5-0.7-0.7-0.6-0.7-0.7-0.7-0.6-0.5-0.50.2
Breakpoint value in progressive ratio session0.80.92.21.10.71.51.50.70.80.60.10.1-1.3
Number of licking bursts4.06.58.12.82.82.42.42.82.82.82.62.6-0.1
Context. condit. distance diff. score2.83.34.3-2.0-2.0-1.7-1.6-2.0-2.0-2.1-1.9-1.9-0.3
Locomotion velocity, session 10.30.31.50.30.30.80.80.10.2-0.0-0.5-0.5-1.2
Locomotion distance, session 11.11.32.1-1.2-1.2-0.7-0.7-1.3-1.2-1.3-1.4-1.4-0.5
Locomotion velocity, session 20.10.10.1-0.3-0.3-0.2-0.3-0.3-0.3-0.2-0.2-0.20.3
Locomotion distance, session 20.60.81.0-1.0-1.0-0.7-0.7-1.0-1.0-1.0-1.0-1.0-0.1
Locomotion velocity, session 31.01.11.9-1.0-1.1-0.5-0.6-1.2-1.1-1.2-1.4-1.4-0.8
Locomotion distance, session 31.71.83.1-1.3-1.4-0.7-0.7-1.5-1.4-1.6-1.7-1.7-1.0
Stereotopy head waving bouts, day 30.60.71.10.80.80.30.40.90.91.01.01.00.6
Stereotopy head waving duration, day 30.20.20.3-0.4-0.5-0.3-0.3-0.4-0.4-0.5-0.6-0.6-0.2
Locomotion velocity, session 70.20.20.50.40.40.60.60.30.40.3-0.1-0.1-0.7
Locomotion distance, session 70.10.20.20.50.50.40.40.50.50.50.20.2-0.1
Stereotopy head waving bouts, day 73.13.54.6-2.0-2.1-1.7-1.7-2.1-2.1-2.1-1.8-1.8-0.2
Stereotopy head waving duration, day 73.34.05.4-2.2-2.3-1.9-2.0-2.2-2.3-2.2-1.8-1.80.3
Locomotion velocity, session 80.91.01.3-1.1-1.1-0.9-0.9-1.1-1.1-1.1-1.1-1.10.0
Locomotion distance, session 82.73.95.0-2.2-2.2-2.0-1.8-2.2-2.2-2.2-2.0-2.00.1
Degree of sensitization distance1.61.73.21.01.10.10.21.31.21.51.81.81.6
Degree of sensitization stereotypy6.36.89.0-2.9-3.0-2.4-2.4-3.0-3.0-3.0-2.6-2.60.0
Conditioned locomotion0.10.20.70.20.10.50.5-0.00.1-0.1-0.4-0.4-0.8
Cocaine response after cond. corrected2.22.63.41.81.71.31.31.91.81.81.91.90.4
Cocaine response after cond. not corrected0.50.60.90.90.80.60.70.90.90.90.90.90.1
Cocaine response before conditioning2.53.04.1-1.8-1.9-1.3-1.3-2.0-1.9-2.0-2.0-2.0-0.7
Saline control response1.41.93.1-1.5-1.6-1.8-1.7-1.3-1.4-1.2-0.8-0.81.1
Bone: connectivity density0.20.31.1-0.1-0.10.50.4-0.2-0.1-0.3-0.7-0.7-1.1
Bone: cortical apparent density2.02.83.71.81.91.61.61.91.91.91.51.5-0.2
Bone: cortical area0.10.20.8-0.4-0.4-0.6-0.7-0.2-0.2-0.10.00.00.9
Bone: cortical porosity0.91.02.0-0.9-1.1-0.5-0.4-1.0-1.0-1.1-1.4-1.4-0.9
Bone: cortical porosity1.11.22.1-1.0-1.2-0.6-0.5-1.1-1.1-1.2-1.4-1.4-0.8
Bone: cortical thickness0.30.40.70.70.70.90.90.70.70.70.20.2-0.6
Bone: cortical thickness0.20.20.5-0.5-0.5-0.3-0.3-0.5-0.5-0.5-0.7-0.7-0.2
Bone: cortical tissue density2.02.73.61.81.91.71.61.81.81.81.41.4-0.3
Condit. Reinf. active minus inactive responses0.20.20.9-0.3-0.3-0.6-0.6-0.1-0.2-0.00.20.20.9
Condit. Reinf. active-inactive response ratio0.40.51.5-0.6-0.6-1.0-1.0-0.4-0.5-0.30.10.11.2
Condit. Reinf. active responses0.00.00.3-0.00.0-0.2-0.20.10.10.20.20.20.5
Condit. Reinf. inactive responses0.00.00.10.20.20.30.30.10.10.1-0.1-0.1-0.3
Incentive salience index mean0.20.20.8-0.5-0.4-0.7-0.7-0.3-0.3-0.2-0.0-0.00.9
Condit. Reinf. lever presses0.20.30.4-0.6-0.6-0.5-0.6-0.5-0.5-0.4-0.4-0.40.4
Condit. Reinf. active minus inactive responses6.58.413.3-3.4-3.2-3.6-3.6-3.0-3.0-2.7-1.7-1.72.3
Condit. Reinf. active-inactive response ratio1.51.72.4-1.5-1.5-1.5-1.6-1.4-1.4-1.3-0.9-0.90.8
Condit. Reinf. active responses8.411.819.2-3.9-3.8-4.3-4.4-3.4-3.5-3.0-1.9-1.93.0
Condit. Reinf. inactive responses4.45.79.9-2.7-2.6-3.1-3.1-2.3-2.4-2.0-1.1-1.12.4
Condit. Reinf. lever presses16.723.132.3-5.6-5.4-5.7-5.7-5.0-5.1-4.7-3.4-3.42.9
Condit. Reinf. lever reinforcers received9.713.521.4-4.2-4.1-4.6-4.6-3.7-3.8-3.3-2.1-2.13.1
Conditioned reinforcement - actives1.52.63.5-1.9-1.7-1.2-1.4-1.8-1.8-1.8-1.8-1.8-0.3
Conditioned reinforcement - inactives0.20.20.40.70.60.50.60.50.40.40.30.3-0.4
Conditioned locomotion3.34.36.6-2.2-1.9-1.3-1.3-2.4-2.2-2.4-2.6-2.6-1.1
Patch foraging indifference point 0 sec3.25.98.7-2.6-2.9-2.6-2.5-2.7-2.7-2.6-2.1-2.10.8
Patch foraging indifference point AUC0.20.31.5-0.0-0.1-0.5-0.60.20.10.30.60.61.2
Delay disc. indifference point, 0s delay1.01.11.6-1.1-1.3-1.3-1.3-1.2-1.2-1.0-0.6-0.60.9
Delay disc. indifference point, 16s delay0.10.10.20.40.20.40.40.20.20.20.10.1-0.3
Delay disc. indifference point, 2s delay0.60.61.5-0.9-0.8-1.1-1.1-0.6-0.7-0.40.20.21.2
Delay disc. indifference point, 24s delay1.01.11.71.31.11.31.31.01.11.00.70.7-0.6
Delay disc. indifference point, 4s delay0.90.92.8-0.8-1.0-1.3-1.3-0.7-0.7-0.40.10.11.7
Delay disc. indifference point, 8s delay0.00.00.20.5-0.20.10.1-0.0-0.00.10.20.20.1
Indifference point function ln k1.52.74.5-1.5-1.6-0.7-0.8-1.9-1.7-1.9-2.1-2.1-1.2
Indifference point function log k1.52.74.5-1.5-1.6-0.7-0.8-1.9-1.7-1.9-2.1-2.1-1.2
Patch foraging total patch changes 0 sec2.64.87.1-2.4-2.7-2.4-2.3-2.4-2.4-2.3-1.8-1.80.9
Patch foraging total patch changes 12 sec0.91.12.8-1.0-1.2-1.5-1.4-0.8-0.8-0.5-0.2-0.21.7
Patch foraging total patch changes 18 sec1.82.85.0-1.9-2.0-2.1-2.2-1.6-1.8-1.5-0.8-0.81.4
Patch foraging total patch changes 24 sec0.61.02.5-1.1-0.8-1.6-1.4-0.7-0.8-0.50.00.01.6
Patch foraging total patch changes 6 sec0.71.11.5-1.1-1.2-1.0-1.0-1.2-1.1-1.0-1.1-1.10.4
Patch foraging time to switch 0 sec2.44.97.22.32.72.72.52.42.42.21.61.6-1.2
Patch foraging water rate 0 sec2.34.97.0-2.4-2.6-2.4-2.2-2.5-2.5-2.3-1.9-1.90.7
Patch foraging water rate 12 sec1.63.44.2-2.0-2.0-1.8-1.6-2.0-2.0-2.0-2.0-2.0-0.2
Patch foraging water rate 18 sec1.01.52.7-1.5-1.3-1.6-1.4-1.3-1.3-1.2-0.9-0.90.7
Patch foraging water rate 24 sec1.72.34.2-1.5-1.5-0.8-0.8-1.6-1.6-1.7-2.0-2.0-1.0
Patch foraging water rate 6 sec1.11.62.2-1.4-1.4-1.1-0.9-1.4-1.4-1.4-1.5-1.5-0.4
Seeking ratio, delayed vs. immediate footshock1.11.32.10.91.41.41.31.31.20.90.50.5-1.3
Distance traveled before self-admin0.81.01.71.01.01.31.01.11.11.10.80.8-0.2
Distance traveled after self-admin0.70.83.60.20.61.41.20.30.40.0-0.5-0.5-1.9
Extensor digitorum longus weight0.31.22.90.70.80.0-0.01.00.91.21.61.61.7
Bone: elastic displacement1.92.34.21.71.62.02.01.41.51.30.60.6-1.5
Bone: elastic work1.72.34.41.71.52.12.11.41.51.20.40.4-1.7
Bone: endosteal estimation1.12.46.4-1.6-1.4-2.2-2.3-1.2-1.2-0.90.10.12.5
Bone: endosteal perimeter1.43.16.2-1.9-1.7-2.4-2.5-1.5-1.5-1.2-0.4-0.42.4
Epididymis fat weight0.41.42.41.21.20.90.71.41.21.21.51.50.3
Delta time in closed arm before/after self-admin2.92.74.71.31.70.80.71.91.71.92.22.21.2
Delta time in open arm before/after self-admin2.42.43.9-1.8-1.8-2.0-1.9-1.5-1.7-1.5-1.0-1.00.9
Diff in mean of infusions in LGA sessions4.85.98.32.62.92.42.72.72.72.52.02.0-1.1
Delay discount exponential model param0.10.10.2-0.4-0.0-0.1-0.1-0.2-0.2-0.3-0.4-0.4-0.3
Extinction: sum of active levers before priming0.10.10.20.1-0.1-0.1-0.20.0-0.00.00.40.40.4
Active lever presses in extinction session 63.53.56.6-1.2-1.9-0.2-0.3-2.1-1.9-2.1-2.6-2.6-1.9
Bone: final force0.10.10.20.40.30.40.40.40.40.40.20.2-0.2
Bone: final moment0.00.00.00.20.10.20.20.20.20.20.00.0-0.0
Food consumed during 24 hour testing period3.64.96.4-2.5-2.5-2.0-2.0-2.5-2.5-2.5-2.3-2.30.0
Glucose0.00.00.10.10.20.20.10.10.20.20.20.20.1
Heart weight0.91.42.1-1.4-1.2-1.0-1.3-1.3-1.3-1.3-1.0-1.00.3
Delay discount hyperbolic model param0.10.10.3-0.30.10.10.1-0.1-0.1-0.3-0.5-0.5-0.6
Intermittent access intake day 1-15 change0.51.12.1-1.0-1.1-0.7-0.6-1.1-1.0-1.0-1.5-1.5-0.4
Intermittent access intake escalation0.71.42.5-1.2-1.3-0.8-0.8-1.3-1.2-1.2-1.6-1.6-0.4
Intermittent access intake escalation 20.91.01.4-1.1-1.1-1.0-0.8-1.2-1.0-0.9-1.2-1.20.1
Intermitt. access day 1 inactive lever presses0.52.03.31.51.81.21.31.51.51.51.41.40.1
Intermitt. access day 15 inactive lever presses0.30.71.50.91.01.21.00.60.70.50.20.2-1.1
Intermitt. access escalation Index0.00.00.1-0.3-0.0-0.2-0.2-0.3-0.2-0.2-0.1-0.10.1
Intermittent access day 1 total infusions1.21.92.9-1.7-1.5-1.4-1.5-1.4-1.5-1.6-1.2-1.20.1
Intermittent access day 15 total infusions1.72.63.3-1.8-1.7-1.4-1.4-1.7-1.7-1.8-1.8-1.8-0.3
Intermittent access terminal intake (last 3 days)2.43.14.1-1.9-2.0-1.6-1.6-2.0-2.0-1.9-1.9-1.90.0
Intermittent access total infusions2.02.33.4-1.8-1.6-1.8-1.8-1.6-1.7-1.6-1.2-1.20.4
Intermittent access day 1 locomotion0.30.40.9-0.7-0.4-0.2-0.5-0.6-0.7-0.8-0.9-0.9-0.4
Intermittent access day 15 total locomotion1.11.93.7-1.3-1.3-0.7-0.8-1.4-1.4-1.6-1.9-1.9-0.8
Intermittent access total locomotion0.91.11.6-1.2-1.1-0.9-1.0-1.1-1.2-1.3-1.2-1.2-0.3
Intermittent access standard deviation0.10.21.0-0.3-0.4-0.5-0.7-0.3-0.2-0.10.10.11.0
Left kidney weight0.20.94.9-0.3-0.3-1.1-1.10.1-0.10.30.90.92.2
Right kidney weight0.31.57.6-0.6-0.4-1.6-1.5-0.0-0.20.31.01.02.8
Cocaine induced anxiety1.52.13.51.81.61.91.71.41.51.40.90.9-0.8
Post-drug Anxiety2.42.63.61.81.91.81.71.71.71.71.41.4-0.5
Baseline Anxiety0.20.20.6-0.4-0.3-0.8-0.6-0.3-0.3-0.30.10.10.5
Tail length0.72.611.9-0.9-0.6-2.2-2.1-0.2-0.30.21.41.43.4
Length with tail0.41.88.1-0.7-0.5-1.9-1.70.0-0.20.21.11.12.8
Length without tail0.10.30.50.50.60.30.30.70.60.60.60.60.2
Times rat made contact with spout0.60.61.20.70.70.30.30.80.80.91.11.10.7
Lifetime Intake2.32.84.2-2.1-1.8-2.0-1.9-1.7-1.8-1.8-1.3-1.30.3
Liver weight, left0.40.72.30.30.5-0.3-0.30.70.60.81.21.21.5
Liver weight, right1.62.85.51.31.50.30.41.71.61.92.32.31.8
Locomotor activity0.71.11.7-0.8-1.2-0.7-0.7-1.2-1.2-1.1-1.3-1.30.0
Locomotor testing distance1.32.33.3-1.6-1.8-1.7-1.8-1.7-1.6-1.4-1.1-1.11.2
Locomotor testing rearing0.30.72.4-0.6-0.8-1.2-1.2-0.5-0.6-0.30.00.01.6
Locomotion in novel chamber1.11.53.2-0.9-1.1-0.3-0.3-1.5-1.2-1.3-1.8-1.8-0.8
Locomotion in novel chamber post-restriction1.82.93.9-2.0-1.7-1.5-1.5-1.9-1.9-1.9-1.8-1.8-0.1
Fecal boli incidents, locomotor time 10.81.22.4-1.0-1.0-0.4-0.4-1.2-1.1-1.2-1.5-1.5-0.8
Change in fecal boli incidents, locomotor task0.70.71.30.51.10.70.71.01.01.00.90.90.0
Time >=10cm from walls, locomotor time 12.32.43.2-1.5-1.8-1.3-1.3-1.8-1.8-1.8-1.7-1.7-0.3
Bouts of movement, locomotor time 10.20.30.4-0.6-0.6-0.4-0.4-0.6-0.6-0.6-0.4-0.40.0
Total resting periods, locomotor time 10.20.30.4-0.6-0.4-0.1-0.1-0.6-0.5-0.7-0.6-0.6-0.6
Rest time, locomotor task time 10.10.21.0-0.10.10.40.4-0.0-0.1-0.3-0.4-0.4-1.0
Distance moved, locomotor task time 10.20.31.60.3-0.1-0.5-0.50.00.10.30.70.71.3
Vertical activity count, locomotor time 10.10.31.1-0.2-0.5-0.8-0.8-0.2-0.3-0.10.20.21.1
Time >=10cm from walls, locomotor time 21.21.72.6-1.3-1.5-1.6-1.6-1.3-1.3-1.2-1.1-1.10.8
Bouts of movement, locomotor time 20.30.52.1-0.9-0.4-1.0-1.0-0.3-0.3-0.10.20.21.5
Total resting periods, locomotor time 20.20.31.5-0.5-0.1-0.6-0.60.00.10.20.40.41.2
Rest time, locomotor task time 22.63.24.51.92.02.02.02.12.01.81.51.5-1.0
Distance moved, locomotor task time 22.63.14.6-1.5-2.1-2.1-2.1-2.0-1.9-1.7-1.2-1.21.4
Vertical activity count, locomotor time 20.81.12.1-0.9-1.3-1.4-1.4-1.0-1.0-0.8-0.4-0.41.3
Light reinforcement 11.74.36.52.62.12.22.22.32.22.21.81.8-0.6
Light reinforcement 20.20.40.90.80.30.90.90.40.40.3-0.2-0.2-0.9
Bone: marrow area0.92.06.1-1.4-1.2-2.0-2.1-1.0-1.0-0.70.20.22.5
Bone: maximum diameter1.32.44.4-1.7-1.6-2.0-2.1-1.4-1.4-1.2-0.6-0.61.8
Bone: maximum force0.00.00.10.30.10.20.20.20.20.2-0.0-0.0-0.1
Bone: maximum moment0.00.00.00.0-0.1-0.0-0.00.0-0.00.0-0.1-0.10.0
Mean time between licks in bursts1.74.28.7-2.1-2.1-2.9-2.9-1.6-1.8-1.3-0.3-0.32.9
Mean num. licks in bursts3.35.26.8-2.5-2.6-2.2-2.2-2.5-2.5-2.5-2.3-2.30.3
Cd content in liver0.60.71.20.80.80.40.40.90.80.91.11.10.8
Co content in liver1.01.22.2-1.1-1.1-1.5-1.5-0.9-1.0-0.8-0.3-0.31.5
Cu content in liver0.60.74.0-0.3-0.3-1.0-1.00.0-0.10.20.80.82.0
Fe content in liver0.00.10.10.30.20.30.30.30.20.20.20.20.0
K content in liver0.30.30.40.40.40.10.10.50.50.60.70.70.6
Mg content in liver0.10.10.2-0.4-0.3-0.4-0.4-0.3-0.3-0.3-0.2-0.20.4
Mn content in liver0.80.92.50.91.01.41.40.60.80.5-0.1-0.1-1.6
Na content in liver0.50.50.7-0.9-0.8-0.8-0.8-0.8-0.8-0.8-0.7-0.70.0
Rb content in liver0.30.40.5-0.7-0.7-0.7-0.7-0.6-0.6-0.6-0.4-0.40.3
Se content in liver4.35.18.02.62.62.82.82.32.32.11.41.4-1.6
Sr content in liver0.20.20.4-0.4-0.4-0.1-0.1-0.5-0.4-0.5-0.6-0.6-0.6
Zn content in liver2.52.84.7-1.9-1.9-2.2-2.2-1.6-1.7-1.4-0.8-0.81.6
Bone: minimum diameter0.71.26.2-0.5-0.3-1.2-1.3-0.0-0.10.31.01.02.5
Time in familiar zone, hab. session 10.10.10.40.10.2-0.2-0.20.20.20.30.50.50.6
Time in novel zone, hab. session 10.30.30.40.60.50.60.60.50.50.50.40.4-0.2
Total zone transitions, hab. session 10.20.31.0-0.2-0.20.20.3-0.3-0.3-0.4-0.9-0.9-1.0
Total locomotion distance, hab. session 11.11.62.71.11.20.40.41.41.31.51.71.71.3
Locomotion velocity, hab. session 10.60.91.40.80.80.20.31.00.91.11.21.21.1
Time in familiar zone, hab. session 21.51.62.6-1.5-1.4-1.6-1.6-1.2-1.3-1.2-0.8-0.81.0
Time in novel zone, hab. session 20.40.40.90.70.61.00.90.50.60.40.10.1-0.8
Total zone transitions, hab. session 21.62.13.0-1.5-1.6-1.0-1.0-1.6-1.6-1.7-1.7-1.7-0.6
Total locomotion distance, hab. session 20.40.62.60.20.2-0.5-0.50.40.30.61.01.01.6
Locomotion velocity, hab. session 20.60.83.10.30.4-0.4-0.40.70.50.81.31.31.8
Novel to familiar place preference ratio0.00.10.1-0.2-0.3-0.3-0.2-0.3-0.3-0.3-0.2-0.2-0.1
Novelty place preference0.10.10.1-0.2-0.3-0.3-0.2-0.3-0.3-0.3-0.2-0.2-0.1
Time in novel zone, NPP test0.20.20.3-0.5-0.5-0.5-0.4-0.5-0.5-0.5-0.4-0.4-0.1
Total zone transitions, NPP test0.30.40.9-0.6-0.6-0.0-0.1-0.7-0.6-0.7-0.9-0.9-0.6
Total locomotion distance, NPP test0.81.02.00.80.90.30.21.00.91.11.41.41.2
Locomotion velocity, NPP test1.11.62.81.11.30.60.51.31.31.41.71.71.1
Intraocular pressure0.40.51.3-0.5-0.5-0.0-0.1-0.7-0.6-0.7-1.1-1.1-0.8
Delta distance traveled before/after self-admin2.02.13.2-1.7-1.2-1.0-1.0-1.6-1.6-1.8-1.7-1.7-0.8
Delta ambulatory time before/after self-admin1.72.13.2-1.7-1.2-1.0-0.9-1.6-1.6-1.8-1.7-1.7-0.9
Parametrial fat weight0.71.72.51.51.40.91.01.61.41.51.51.50.2
Pavlov. Cond. lever latency1.51.92.61.61.61.51.61.51.51.31.01.0-0.8
Pavlov. Cond. magazine entry latency3.24.15.8-2.3-2.4-2.4-2.4-2.1-2.2-2.0-1.4-1.41.3
Pavlov. Cond. change in total contacts1.41.52.1-1.4-1.4-1.5-1.4-1.3-1.3-1.2-0.9-0.90.8
Pavlov. Cond. index score2.83.65.1-2.1-2.2-2.2-2.3-2.0-2.0-1.8-1.3-1.31.2
Pavlov. Cond. latency score2.73.54.8-2.1-2.2-2.1-2.2-1.9-2.0-1.8-1.3-1.31.2
Pavlov. Cond. lever contacts1.31.62.4-1.5-1.5-1.4-1.5-1.3-1.3-1.2-0.9-0.90.9
Pavlov. Cond. magazine entry number3.34.25.92.32.42.42.42.22.22.01.51.5-1.2
Pavlov. Cond. intertrial magazine entries0.91.11.71.21.21.31.31.11.11.00.70.7-0.8
Pavlov. Cond. lever-magazine prob. diff.2.32.84.0-1.9-2.0-2.0-2.0-1.8-1.8-1.6-1.1-1.11.1
Pavlov. Cond. response bias1.51.92.7-1.6-1.6-1.6-1.7-1.4-1.5-1.3-1.0-1.00.9
Pavlov. Cond. lever latency18.525.233.65.85.75.75.75.45.45.04.04.0-2.5
Pavlov. Cond. magazine entry latency4.75.67.3-2.7-2.7-2.4-2.4-2.6-2.6-2.5-2.3-2.30.4
Pavlov. Cond. change in total contacts11.919.025.2-5.0-5.0-4.9-4.9-4.7-4.7-4.4-3.5-3.52.0
Pavlov. Cond. index score13.818.624.7-5.0-4.9-4.9-4.8-4.6-4.6-4.3-3.5-3.52.0
Pavlov. Cond. latency score12.316.321.9-4.7-4.6-4.5-4.5-4.3-4.3-4.1-3.4-3.41.8
Pavlov. Cond. lever contacts17.223.831.5-5.6-5.6-5.6-5.6-5.2-5.2-4.8-3.8-3.82.5
Pavlov. Cond. magazine entry number7.99.812.63.53.63.23.23.43.43.32.92.9-0.6
Pavlov. Cond. intertrial magazine entries0.40.62.70.10.1-0.6-0.60.30.30.51.11.11.6
Pavlov. Cond. lever-magazine prob. diff.12.817.122.7-4.8-4.7-4.8-4.7-4.4-4.4-4.1-3.3-3.32.0
Pavlov. Cond. response bias18.124.632.5-5.7-5.7-5.6-5.6-5.3-5.3-5.0-4.0-4.02.3
Time in closed arm before self-admin2.43.05.3-1.6-1.6-0.8-0.9-2.0-1.9-2.1-2.3-2.3-1.1
Time in closed arm after self-admin0.60.71.90.61.01.41.10.60.70.5-0.1-0.1-1.1
Time in open arm before self-admin3.63.95.72.42.01.82.12.22.22.21.91.9-0.3
Time in open arm after self-admin0.30.31.10.1-0.3-0.8-0.50.10.00.20.60.61.1
Bone: periosteal estimation0.81.74.5-1.3-1.2-1.8-1.9-1.0-1.0-0.7-0.0-0.02.1
Bone: periosteal perimeter0.91.63.7-1.3-1.2-1.8-1.8-1.0-1.0-0.8-0.2-0.21.9
Bone: post-yield work0.00.00.1-0.2-0.2-0.3-0.3-0.2-0.2-0.10.00.00.3
Progressive ratio test 1 active lever presses0.10.10.5-0.30.20.20.10.0-0.1-0.3-0.3-0.3-0.7
Progressive ratio test 1 breakpoint0.10.10.4-0.30.20.20.10.0-0.1-0.2-0.3-0.3-0.6
Progressive ratio test 1 inactive lever presses0.10.10.30.10.30.30.20.40.1-0.10.20.2-0.6
Progressive ratio test 2 active lever presses0.40.50.8-0.7-0.8-0.9-0.9-0.7-0.8-0.7-0.5-0.50.3
Progressive ratio test 2 breakpoint0.50.50.8-0.8-0.8-0.9-0.9-0.7-0.8-0.7-0.6-0.60.3
Progressive ratio test 2 inactive lever presses0.20.40.6-0.4-0.7-0.4-0.5-0.6-0.7-0.8-0.7-0.7-0.5
Incentive Sensitization - Responses0.60.91.7-0.7-1.3-1.3-1.1-1.0-1.0-0.8-0.7-0.70.6
Incentive Sensitization - Breakpoint0.70.91.6-0.7-1.3-1.2-1.0-1.0-1.0-0.8-0.8-0.80.5
Sum of active levers in priming session hrs 5-60.20.20.40.5-0.40.40.4-0.2-0.1-0.2-0.5-0.5-0.6
Progressive ratio0.40.61.2-0.5-0.9-0.3-0.5-0.9-0.8-0.9-1.1-1.1-0.5
Food seeking constrained by brief footshock1.01.22.3-1.1-1.3-1.4-1.5-1.0-1.0-0.8-0.4-0.41.5
Seeking ratio, punishment vs. effort0.60.84.1-0.6-0.3-1.1-1.0-0.0-0.10.10.90.92.0
Retroperitoneal fat weight2.812.022.33.33.31.61.63.83.53.94.74.72.5
Reaction time number correct0.50.92.3-0.2-0.60.30.4-0.8-0.6-0.8-1.4-1.4-1.5
Reaction time mean minus median0.30.81.5-0.9-1.1-1.2-1.1-0.8-0.9-0.7-0.3-0.30.8
Reaction time mean minus median AUC0.61.42.2-1.3-1.5-1.3-1.2-1.2-1.3-1.3-1.0-1.00.2
Reaction time num false alarms2.23.13.81.91.91.61.61.91.91.91.91.90.2
Reaction time num false alarms AUC1.01.51.91.41.31.31.11.31.31.31.31.30.0
Reaction time trials correct on left0.50.92.3-0.2-0.60.30.4-0.8-0.6-0.8-1.4-1.4-1.5
Reaction time trials on left0.50.92.4-0.2-0.60.40.5-0.8-0.6-0.8-1.4-1.4-1.5
Reaction time mean0.91.52.41.41.20.80.91.31.21.31.61.60.2
Reaction time mean AUC1.11.82.51.51.41.01.21.51.41.41.61.6-0.2
Median of all reaction times1.82.53.41.91.71.31.41.71.61.71.81.8-0.2
Reaction time omissions0.20.30.70.60.30.20.10.60.50.60.80.80.6
Reaction time false alarm rate1.72.43.81.51.71.11.01.71.61.71.91.90.7
Reaction time premature initiation rate1.21.66.2-1.1-0.9-1.7-1.9-0.6-0.7-0.30.50.52.5
Reaction time premature initiations0.71.32.3-1.3-1.3-1.4-1.5-1.1-1.1-0.9-0.5-0.51.3
Std. dev. reaction times0.30.52.2-0.2-0.2-0.8-0.70.1-0.00.30.80.81.5
Reaction time trials completed0.50.92.4-0.2-0.60.40.5-0.8-0.6-0.8-1.4-1.4-1.5
Reaction time trials AUC0.40.71.6-0.2-0.60.30.4-0.8-0.5-0.7-1.3-1.3-1.3
Run reversals in cocaine runway, females2.42.35.60.91.0-0.2-0.21.41.21.52.42.42.1
Run reversals in cocaine runway, males0.10.10.10.20.30.40.20.30.20.20.30.3-0.3
Latency to leave start box in cocaine runway4.34.96.92.32.41.51.72.62.52.62.52.50.4
Latency to leave start box in cocaine runway, F4.65.38.32.22.41.21.42.72.52.72.92.91.1
Latency to leave start box in cocaine runway, M0.40.30.60.60.70.70.80.60.60.50.20.2-0.7
Std. dev. time between licks in bursts1.01.45.9-0.8-0.8-1.6-1.6-0.4-0.5-0.10.60.62.4
Total sessions with >9 infusions2.73.25.9-2.4-1.8-2.2-2.3-1.7-1.9-1.8-1.2-1.20.8
Short access day 1 total inactive lever presses0.00.10.2-0.30.1-0.4-0.20.40.0-0.10.30.30.0
Short access day 10 total inactive lever presses0.30.71.31.11.11.11.10.80.90.80.40.4-0.6
Short access day 1 total infusions3.34.37.4-2.7-2.3-2.7-2.7-1.9-2.2-2.0-1.1-1.11.3
Short access day 10 total infusions1.82.33.7-1.9-1.6-1.8-1.9-1.6-1.6-1.5-1.0-1.00.8
Short access total infusions2.53.24.9-2.2-1.9-2.2-2.2-1.7-1.9-1.9-1.2-1.20.6
Short access day 1 locomotion2.53.24.2-2.0-2.0-1.6-1.7-1.9-2.0-2.1-1.8-1.8-0.2
Short access day 10 total locomotion1.12.02.7-1.6-1.5-1.3-1.4-1.6-1.5-1.4-1.5-1.50.6
Short access total locomotion0.81.01.4-1.0-1.0-0.6-0.9-1.1-1.1-1.1-1.2-1.2-0.2
One hour access (0.3 mA shock)1.61.92.3-1.5-1.4-1.4-1.4-1.5-1.4-1.4-1.4-1.40.2
Compulsive drug intake0.91.14.11.10.41.41.60.30.40.2-0.6-0.6-2.0
One hour access (shock baseline)2.03.14.8-2.2-1.8-2.1-2.0-1.8-1.8-1.8-1.5-1.50.7
Social response proportion0.50.61.00.61.00.30.40.90.91.00.90.90.6
Social responses0.81.12.20.70.9-0.10.11.10.91.11.51.51.3
Social time2.12.94.11.92.02.02.01.91.91.61.01.0-1.3
Soleus weight0.82.46.60.90.9-0.1-0.21.31.21.62.22.22.6
Bone: stiffness0.61.01.31.01.10.70.71.11.11.11.11.10.3
Tibialis anterior weight0.10.31.9-0.1-0.1-0.5-0.60.20.10.30.60.61.4
Time to tail flick, vehicle, before self-admin0.30.30.6-0.3-0.5-0.3-0.3-0.7-0.5-0.6-0.8-0.8-0.1
Time to tail flick, vehicle, after self-admin1.41.83.4-1.8-1.5-1.3-1.6-1.2-1.4-1.5-1.1-1.10.3
Time to tail flick, test, before self-admin0.50.51.7-0.4-0.5-1.0-1.0-0.4-0.4-0.20.60.61.3
Time to tail flick, test, after self-admin0.40.51.9-0.2-0.2-1.0-0.8-0.1-0.10.10.70.71.4
Delta time to tail flick, vehicle, before/after SA0.60.61.4-1.2-0.9-0.8-1.1-0.5-0.8-0.8-0.3-0.30.3
Delta time to tail flick, test, before/after SA0.30.40.60.60.80.60.70.70.70.70.40.4-0.4
Tibia length2.05.67.7-2.5-2.6-1.7-1.7-2.7-2.6-2.7-2.8-2.8-0.7
Ambulatory time before self-admin0.71.02.40.91.11.61.21.01.11.00.50.5-0.7
Ambulatory time after self-admin0.81.04.2-0.60.10.90.6-0.4-0.3-0.7-1.2-1.2-2.0
Bone: tissue strength0.80.83.80.50.31.21.20.20.2-0.0-0.6-0.6-1.9
Total heroin consumption0.10.10.20.0-0.4-0.10.1-0.2-0.2-0.3-0.4-0.4-0.4
Bone: trabecular number0.91.53.01.31.31.71.71.01.21.00.40.4-1.5
Bone: trabecular spacing0.91.21.7-1.2-1.3-1.1-1.1-1.2-1.2-1.2-1.0-1.00.2
Bone: trabecular thickness0.60.70.91.00.90.90.80.90.91.00.80.8-0.1
Bone: trabecular tissue density2.03.04.41.81.81.11.11.91.92.02.12.10.9
Water consumed over 24 hours0.30.40.70.70.70.80.80.70.70.60.40.4-0.5
Number of responses in last shaping day0.60.71.40.60.80.30.10.80.80.91.21.20.9