Time in open arm before self-admin

Time spent in the open arm during the first time point of elevated plus maze before self admin

Tags: Behavior · Heroin · Elevated plus maze

Project: u01_peter_kalivas

3 loci · 3 genes with independent associations · 3 total associated genes

Significant Loci

# Chr Start pos End pos # assoc genes # joint models Best TWAS P Best GWAS P Cond GWAS P Joint genes
1 chr3 153329192 154718613 1 1 5.91e-08 5.71e-02 4.89e-01 Slc35c2
2 chr5 151116412 152307872 1 1 4.25e-08 3.20e-03 2.57e-01 Emc1
3 chr7 14449451 15768722 1 1 2.37e-08 4.91e-01 1.00e+00 LOC102551633

Pleiotropic Associations

Trait Chi2 ratio # genes+ # genes++ % genes++ Corr Corr P Genes
Body weight 1.74 1 0 0 0 1e+00 Emc1
Parametrial fat weight 14.02 1 1 33.3 0 1e+00 Slc35c2
Number of licking bursts 7.96 1 0 0 0 1e+00 Emc1
Patch foraging indifference point 0 sec 7.74 1 0 0 0 1e+00 LOC102551633
Patch foraging total patch changes 0 sec 7.23 1 0 0 0 1e+00 LOC102551633
Patch foraging total patch changes 12 sec 4.78 1 0 0 0 1e+00 Slc35c2
Patch foraging total patch changes 6 sec 5.65 1 0 0 0 1e+00 LOC102551633
Locomotor activity 4.19 1 0 0 0 1e+00 LOC102551633
Locomotor testing distance 3.92 1 0 0 0 1e+00 LOC102551633
Light reinforcement 2 9.1 1 0 0 0 1e+00 Slc35c2
Reaction time number correct 4.21 1 0 0 0 1e+00 Emc1
Reaction time trials correct on left 4.21 1 0 0 0 1e+00 Emc1
Reaction time trials on left 4.15 1 0 0 0 1e+00 Emc1
Reaction time omissions 6.2 1 0 0 0 1e+00 Slc35c2
Reaction time trials completed 4.15 1 0 0 0 1e+00 Emc1
Reaction time trials AUC 4.12 1 0 0 0 1e+00 Emc1
Conditioned reinforcement - actives 6.27 1 0 0 0 1e+00 LOC102551633
Conditioned reinforcement - inactives 5.74 1 0 0 0 1e+00 LOC102551633
Conditioned locomotion 30.34 2 1 33.3 0 1e+00 LOC102551633 Slc35c2
Intermittent access intake day 1-15 change 12.16 2 0 0 0 1e+00 Emc1 Slc35c2
Intermittent access intake escalation 7.7 2 0 0 0 1e+00 Emc1 Slc35c2
Intermittent access intake escalation 2 13.41 1 0 0 0 1e+00 LOC102551633
Intermitt. access escalation Index 57.91 1 1 33.3 0 1e+00 LOC102551633
Intermittent access day 1 total infusions 19.51 1 0 0 0 1e+00 LOC102551633
Intermittent access day 15 total infusions 5.7 2 0 0 0 1e+00 Emc1 LOC102551633
Intermittent access terminal intake (last 3 days) 31.99 2 1 33.3 0 1e+00 Emc1 LOC102551633
Intermittent access total infusions 12.85 1 0 0 0 1e+00 LOC102551633
Intermittent access day 15 total locomotion 19.33 2 1 33.3 0 1e+00 LOC102551633 Slc35c2
Intermittent access total locomotion 10.55 2 0 0 0 1e+00 LOC102551633 Slc35c2
Lifetime Intake 15.71 1 0 0 0 1e+00 LOC102551633
Incentive Sensitization - Responses 8.44 1 0 0 0 1e+00 LOC102551633
Incentive Sensitization - Breakpoint 6.89 1 0 0 0 1e+00 LOC102551633
Progressive ratio test 1 active lever presses 16.85 1 0 0 0 1e+00 LOC102551633
Progressive ratio test 1 breakpoint 36.73 1 1 33.3 0 1e+00 LOC102551633
Progressive ratio test 1 inactive lever presses 30.05 1 1 33.3 0 1e+00 LOC102551633
Progressive ratio test 2 inactive lever presses 22.31 1 0 0 0 1e+00 LOC102551633
Short access day 1 total inactive lever presses 7.07 1 0 0 0 1e+00 LOC102551633
Short access day 10 total inactive lever presses 11.23 2 0 0 0 1e+00 LOC102551633 Slc35c2
Short access day 1 total infusions 71.59 1 1 33.3 0 1e+00 LOC102551633
Short access day 10 total infusions 30.94 1 1 33.3 0 1e+00 LOC102551633
Short access total infusions 43.84 1 1 33.3 0 1e+00 LOC102551633
Short access day 1 locomotion 22.2 1 0 0 0 1e+00 LOC102551633
One hour access (shock baseline) 6.09 1 0 0 0 1e+00 LOC102551633
Number of responses in last shaping day 16.84 1 0 0 0 1e+00 LOC102551633
Locomotion distance, session 1 5.65 1 0 0 0 1e+00 Emc1
Degree of sensitization distance 11.08 1 0 0 0 1e+00 LOC102551633
Condit. Reinf. active minus inactive responses 10.59 1 0 0 0 1e+00 Emc1
Condit. Reinf. active-inactive response ratio 6.83 1 0 0 0 1e+00 Emc1
Condit. Reinf. active responses 13.7 1 0 0 0 1e+00 Emc1
Incentive salience index mean 6.27 1 0 0 0 1e+00 Emc1
Novel to familiar place preference ratio 11.89 1 0 0 0 1e+00 Emc1
Novelty place preference 11.97 1 0 0 0 1e+00 Emc1
Time in novel zone, NPP test 10.41 1 0 0 0 1e+00 Emc1
Pavlov. Cond. lever latency 5.45 1 0 0 0 1e+00 LOC102551633
Pavlov. Cond. latency score 4.54 1 0 0 0 1e+00 LOC102551633
Pavlov. Cond. lever contacts 5.74 1 0 0 0 1e+00 LOC102551633
Bone: cortical area 6.14 1 0 0 0 1e+00 Slc35c2
Bone: cortical thickness 10.4 1 0 0 0 1e+00 Slc35c2
Bone: final force 3.95 1 0 0 0 1e+00 LOC102551633
Bone: final moment 3.68 1 0 0 0 1e+00 LOC102551633
Bone: maximum force 3.84 1 0 0 0 1e+00 LOC102551633
Bone: maximum moment 3.51 1 0 0 0 1e+00 LOC102551633
Bone: stiffness 4.3 2 0 0 0 1e+00 Emc1 LOC102551633
Distance traveled before self-admin 30.86 2 1 33.3 0 1e+00 LOC102551633 Slc35c2
Distance traveled after self-admin 27.05 2 1 33.3 0 1e+00 LOC102551633 Slc35c2
Diff in mean of infusions in LGA sessions 5.75 1 0 0 0 1e+00 Emc1
Extinction: sum of active levers before priming 28.64 2 1 33.3 0 1e+00 LOC102551633 Slc35c2
Delta ambulatory time before/after self-admin 13.21 1 0 0 0 1e+00 LOC102551633
Time in closed arm before self-admin 19.47 2 0 0 0 1e+00 Emc1 Slc35c2
Time in closed arm after self-admin 6.68 2 0 0 0 1e+00 Emc1 LOC102551633
Time in open arm after self-admin 10.71 2 0 0 0 1e+00 LOC102551633 Slc35c2
Sum of active levers in priming session hrs 5-6 18.99 1 0 0 0 1e+00 LOC102551633
Time to tail flick, vehicle, before self-admin 30.15 2 1 33.3 0 1e+00 Emc1 LOC102551633
Time to tail flick, vehicle, after self-admin 51.7 1 1 33.3 0 1e+00 LOC102551633
Time to tail flick, test, before self-admin 19.7 1 0 0 0 1e+00 Emc1
Delta time to tail flick, vehicle, before/after SA 68.48 2 1 33.3 0 1e+00 LOC102551633 Slc35c2
Ambulatory time before self-admin 9.91 2 0 0 0 1e+00 LOC102551633 Slc35c2
Ambulatory time after self-admin 12.5 2 0 0 0 1e+00 LOC102551633 Slc35c2
Total heroin consumption 30.8 1 1 33.3 0 1e+00 LOC102551633
Delay disc. indifference point, 16s delay 12.72 1 0 0 0 1e+00 Slc35c2
Fecal boli incidents, locomotor time 1 11.06 2 0 0 0 1e+00 Emc1 Slc35c2
Distance moved, locomotor task time 1 12.57 1 0 0 0 1e+00 Emc1
Vertical activity count, locomotor time 1 7.34 1 0 0 0 1e+00 Emc1
Bouts of movement, locomotor time 2 12.09 1 0 0 0 1e+00 Slc35c2
Total resting periods, locomotor time 2 16.17 1 0 0 0 1e+00 Slc35c2
Rest time, locomotor task time 2 7.29 1 0 0 0 1e+00 Slc35c2
Distance moved, locomotor task time 2 9.53 1 0 0 0 1e+00 Slc35c2
Seeking ratio, delayed vs. immediate footshock 9.35 1 0 0 0 1e+00 LOC102551633
Locomotion in novel chamber 6.8 1 0 0 0 1e+00 Emc1
Locomotion in novel chamber post-restriction 7.77 1 0 0 0 1e+00 Emc1
Co content in liver 12.69 1 0 0 0 1e+00 LOC102551633
Fe content in liver 7.51 1 0 0 0 1e+00 LOC102551633
K content in liver 11.66 1 0 0 0 1e+00 LOC102551633
Na content in liver 44.6 1 1 33.3 0 1e+00 LOC102551633
Rb content in liver 16.75 1 0 0 0 1e+00 LOC102551633
Se content in liver 12.37 1 0 0 0 1e+00 LOC102551633

Associations by panel

Tissue RNA modality # hits % hits/tests Avg chisq
Adipose alternative polyA 0 0 1.13
Adipose alternative TSS 0 0 1.17
Adipose gene expression 0 0 1.06
Adipose isoform ratio 0 0 1.09
Adipose intron excision ratio 0 0 1.04
Adipose mRNA stability 0 0 1.09
BLA alternative polyA 0 0 1.18
BLA alternative TSS 0 0 1.08
BLA gene expression 0 0 1.08
BLA isoform ratio 0 0 1.09
BLA intron excision ratio 0 0 1.03
BLA mRNA stability 0 0 1.12
Brain alternative polyA 0 0 1.12
Brain alternative TSS 0 0 1.12
Brain gene expression 0 0 1.09
Brain isoform ratio 0 0 1.09
Brain intron excision ratio 0 0 1.04
Brain mRNA stability 0 0 1.08
Eye alternative polyA 0 0 1.2
Eye alternative TSS 0 0 1.2
Eye gene expression 0 0 1.13
Eye isoform ratio 0 0 0.95
Eye intron excision ratio 0 0 1.15
Eye mRNA stability 0 0 1.25
IL alternative polyA 0 0 1.21
IL alternative TSS 0 0 1.01
IL gene expression 0 0 1.06
IL isoform ratio 0 0 1.13
IL intron excision ratio 0 0 0.95
IL mRNA stability 0 0 1.11
LHb alternative polyA 0 0 1.13
LHb alternative TSS 0 0 1.03
LHb gene expression 0 0 1.05
LHb isoform ratio 0 0 1.09
LHb intron excision ratio 0 0 0.89
LHb mRNA stability 0 0 1.1
Liver alternative polyA 0 0 1.09
Liver alternative TSS 0 0 1.04
Liver gene expression 0 0 1.09
Liver isoform ratio 0 0 1.03
Liver intron excision ratio 0 0 1.03
Liver mRNA stability 0 0 1.08
NAcc alternative polyA 1 0 1.15
NAcc alternative TSS 0 0 1.16
NAcc gene expression 0 0 1.08
NAcc isoform ratio 0 0 1.1
NAcc intron excision ratio 0 0 1.04
NAcc mRNA stability 0 0 1.1
OFC alternative polyA 0 0 1.27
OFC alternative TSS 0 0 1.16
OFC gene expression 0 0 1.03
OFC isoform ratio 0 0 1.13
OFC intron excision ratio 0 0 0.99
OFC mRNA stability 0 0 1.08
PL alternative polyA 0 0 1.18
PL alternative TSS 0 0 1.11
PL gene expression 0 0 1.08
PL isoform ratio 0 0 1.09
PL intron excision ratio 0 0 1.07
PL mRNA stability 0 0 1.13
pVTA alternative polyA 0 0 1.15
pVTA alternative TSS 0 0 1.18
pVTA gene expression 0 0 1.08
pVTA isoform ratio 0 0 1.1
pVTA intron excision ratio 1 0 1.04
pVTA mRNA stability 0 0 1.12
RMTg alternative polyA 1 0.2 1.17
RMTg alternative TSS 0 0 1.08
RMTg gene expression 0 0 1.08
RMTg isoform ratio 0 0 1.14
RMTg intron excision ratio 0 0 1.01
RMTg mRNA stability 0 0 1.06