Hub : Traits

Time in open arm before self-admin

Time spent in the open arm during the first time point of elevated plus maze before self admin

Tags: Behavior · Heroin · Elevated plus maze

Project: u01_peter_kalivas

3 loci · 3 genes with independent associations · 3 total associated genes

Significant Loci

#	Chr	Start pos	End pos	# assoc genes	# joint models	Best TWAS P	Best GWAS P	Cond GWAS P	Joint genes
1	chr3	153329192	154718613	1	1	5.91e-08	5.71e-02	4.89e-01	Slc35c2
2	chr5	151116412	152307872	1	1	4.25e-08	3.20e-03	2.57e-01	Emc1
3	chr7	14449451	15768722	1	1	2.37e-08	4.91e-01	1.00e+00	LOC102551633

Pleiotropic Associations

Trait	Chi2 ratio	# genes+	# genes++	% genes++	Corr	Corr P	Genes
Body weight	1.74	1	0	0	0	1e+00	Emc1
Parametrial fat weight	14.02	1	1	33.3	0	1e+00	Slc35c2
Number of licking bursts	7.96	1	0	0	0	1e+00	Emc1
Patch foraging indifference point 0 sec	7.74	1	0	0	0	1e+00	LOC102551633
Patch foraging total patch changes 0 sec	7.23	1	0	0	0	1e+00	LOC102551633
Patch foraging total patch changes 12 sec	4.78	1	0	0	0	1e+00	Slc35c2
Patch foraging total patch changes 6 sec	5.65	1	0	0	0	1e+00	LOC102551633
Locomotor activity	4.19	1	0	0	0	1e+00	LOC102551633
Locomotor testing distance	3.92	1	0	0	0	1e+00	LOC102551633
Light reinforcement 2	9.1	1	0	0	0	1e+00	Slc35c2
Reaction time number correct	4.21	1	0	0	0	1e+00	Emc1
Reaction time trials correct on left	4.21	1	0	0	0	1e+00	Emc1
Reaction time trials on left	4.15	1	0	0	0	1e+00	Emc1
Reaction time omissions	6.2	1	0	0	0	1e+00	Slc35c2
Reaction time trials completed	4.15	1	0	0	0	1e+00	Emc1
Reaction time trials AUC	4.12	1	0	0	0	1e+00	Emc1
Conditioned reinforcement - actives	6.27	1	0	0	0	1e+00	LOC102551633
Conditioned reinforcement - inactives	5.74	1	0	0	0	1e+00	LOC102551633
Conditioned locomotion	30.34	2	1	33.3	0	1e+00	LOC102551633 Slc35c2
Intermittent access intake day 1-15 change	12.16	2	0	0	0	1e+00	Emc1 Slc35c2
Intermittent access intake escalation	7.7	2	0	0	0	1e+00	Emc1 Slc35c2
Intermittent access intake escalation 2	13.41	1	0	0	0	1e+00	LOC102551633
Intermitt. access escalation Index	57.91	1	1	33.3	0	1e+00	LOC102551633
Intermittent access day 1 total infusions	19.51	1	0	0	0	1e+00	LOC102551633
Intermittent access day 15 total infusions	5.7	2	0	0	0	1e+00	Emc1 LOC102551633
Intermittent access terminal intake (last 3 days)	31.99	2	1	33.3	0	1e+00	Emc1 LOC102551633
Intermittent access total infusions	12.85	1	0	0	0	1e+00	LOC102551633
Intermittent access day 15 total locomotion	19.33	2	1	33.3	0	1e+00	LOC102551633 Slc35c2
Intermittent access total locomotion	10.55	2	0	0	0	1e+00	LOC102551633 Slc35c2
Lifetime Intake	15.71	1	0	0	0	1e+00	LOC102551633
Incentive Sensitization - Responses	8.44	1	0	0	0	1e+00	LOC102551633
Incentive Sensitization - Breakpoint	6.89	1	0	0	0	1e+00	LOC102551633
Progressive ratio test 1 active lever presses	16.85	1	0	0	0	1e+00	LOC102551633
Progressive ratio test 1 breakpoint	36.73	1	1	33.3	0	1e+00	LOC102551633
Progressive ratio test 1 inactive lever presses	30.05	1	1	33.3	0	1e+00	LOC102551633
Progressive ratio test 2 inactive lever presses	22.31	1	0	0	0	1e+00	LOC102551633
Short access day 1 total inactive lever presses	7.07	1	0	0	0	1e+00	LOC102551633
Short access day 10 total inactive lever presses	11.23	2	0	0	0	1e+00	LOC102551633 Slc35c2
Short access day 1 total infusions	71.59	1	1	33.3	0	1e+00	LOC102551633
Short access day 10 total infusions	30.94	1	1	33.3	0	1e+00	LOC102551633
Short access total infusions	43.84	1	1	33.3	0	1e+00	LOC102551633
Short access day 1 locomotion	22.2	1	0	0	0	1e+00	LOC102551633
One hour access (shock baseline)	6.09	1	0	0	0	1e+00	LOC102551633
Number of responses in last shaping day	16.84	1	0	0	0	1e+00	LOC102551633
Locomotion distance, session 1	5.65	1	0	0	0	1e+00	Emc1
Degree of sensitization distance	11.08	1	0	0	0	1e+00	LOC102551633
Condit. Reinf. active minus inactive responses	10.59	1	0	0	0	1e+00	Emc1
Condit. Reinf. active-inactive response ratio	6.83	1	0	0	0	1e+00	Emc1
Condit. Reinf. active responses	13.7	1	0	0	0	1e+00	Emc1
Incentive salience index mean	6.27	1	0	0	0	1e+00	Emc1
Novel to familiar place preference ratio	11.89	1	0	0	0	1e+00	Emc1
Novelty place preference	11.97	1	0	0	0	1e+00	Emc1
Time in novel zone, NPP test	10.41	1	0	0	0	1e+00	Emc1
Pavlov. Cond. lever latency	5.45	1	0	0	0	1e+00	LOC102551633
Pavlov. Cond. latency score	4.54	1	0	0	0	1e+00	LOC102551633
Pavlov. Cond. lever contacts	5.74	1	0	0	0	1e+00	LOC102551633
Bone: cortical area	6.14	1	0	0	0	1e+00	Slc35c2
Bone: cortical thickness	10.4	1	0	0	0	1e+00	Slc35c2
Bone: final force	3.95	1	0	0	0	1e+00	LOC102551633
Bone: final moment	3.68	1	0	0	0	1e+00	LOC102551633
Bone: maximum force	3.84	1	0	0	0	1e+00	LOC102551633
Bone: maximum moment	3.51	1	0	0	0	1e+00	LOC102551633
Bone: stiffness	4.3	2	0	0	0	1e+00	Emc1 LOC102551633
Distance traveled before self-admin	30.86	2	1	33.3	0	1e+00	LOC102551633 Slc35c2
Distance traveled after self-admin	27.05	2	1	33.3	0	1e+00	LOC102551633 Slc35c2
Diff in mean of infusions in LGA sessions	5.75	1	0	0	0	1e+00	Emc1
Extinction: sum of active levers before priming	28.64	2	1	33.3	0	1e+00	LOC102551633 Slc35c2
Delta ambulatory time before/after self-admin	13.21	1	0	0	0	1e+00	LOC102551633
Time in closed arm before self-admin	19.47	2	0	0	0	1e+00	Emc1 Slc35c2
Time in closed arm after self-admin	6.68	2	0	0	0	1e+00	Emc1 LOC102551633
Time in open arm after self-admin	10.71	2	0	0	0	1e+00	LOC102551633 Slc35c2
Sum of active levers in priming session hrs 5-6	18.99	1	0	0	0	1e+00	LOC102551633
Time to tail flick, vehicle, before self-admin	30.15	2	1	33.3	0	1e+00	Emc1 LOC102551633
Time to tail flick, vehicle, after self-admin	51.7	1	1	33.3	0	1e+00	LOC102551633
Time to tail flick, test, before self-admin	19.7	1	0	0	0	1e+00	Emc1
Delta time to tail flick, vehicle, before/after SA	68.48	2	1	33.3	0	1e+00	LOC102551633 Slc35c2
Ambulatory time before self-admin	9.91	2	0	0	0	1e+00	LOC102551633 Slc35c2
Ambulatory time after self-admin	12.5	2	0	0	0	1e+00	LOC102551633 Slc35c2
Total heroin consumption	30.8	1	1	33.3	0	1e+00	LOC102551633
Delay disc. indifference point, 16s delay	12.72	1	0	0	0	1e+00	Slc35c2
Fecal boli incidents, locomotor time 1	11.06	2	0	0	0	1e+00	Emc1 Slc35c2
Distance moved, locomotor task time 1	12.57	1	0	0	0	1e+00	Emc1
Vertical activity count, locomotor time 1	7.34	1	0	0	0	1e+00	Emc1
Bouts of movement, locomotor time 2	12.09	1	0	0	0	1e+00	Slc35c2
Total resting periods, locomotor time 2	16.17	1	0	0	0	1e+00	Slc35c2
Rest time, locomotor task time 2	7.29	1	0	0	0	1e+00	Slc35c2
Distance moved, locomotor task time 2	9.53	1	0	0	0	1e+00	Slc35c2
Seeking ratio, delayed vs. immediate footshock	9.35	1	0	0	0	1e+00	LOC102551633
Locomotion in novel chamber	6.8	1	0	0	0	1e+00	Emc1
Locomotion in novel chamber post-restriction	7.77	1	0	0	0	1e+00	Emc1
Co content in liver	12.69	1	0	0	0	1e+00	LOC102551633
Fe content in liver	7.51	1	0	0	0	1e+00	LOC102551633
K content in liver	11.66	1	0	0	0	1e+00	LOC102551633
Na content in liver	44.6	1	1	33.3	0	1e+00	LOC102551633
Rb content in liver	16.75	1	0	0	0	1e+00	LOC102551633
Se content in liver	12.37	1	0	0	0	1e+00	LOC102551633

Associations by panel

Tissue	RNA modality	# hits	% hits/tests	Avg chisq
Adipose	alternative polyA	0	0	1.13
Adipose	alternative TSS	0	0	1.17
Adipose	gene expression	0	0	1.06
Adipose	isoform ratio	0	0	1.09
Adipose	intron excision ratio	0	0	1.04
Adipose	mRNA stability	0	0	1.09
BLA	alternative polyA	0	0	1.18
BLA	alternative TSS	0	0	1.08
BLA	gene expression	0	0	1.08
BLA	isoform ratio	0	0	1.09
BLA	intron excision ratio	0	0	1.03
BLA	mRNA stability	0	0	1.12
Brain	alternative polyA	0	0	1.12
Brain	alternative TSS	0	0	1.12
Brain	gene expression	0	0	1.09
Brain	isoform ratio	0	0	1.09
Brain	intron excision ratio	0	0	1.04
Brain	mRNA stability	0	0	1.08
Eye	alternative polyA	0	0	1.2
Eye	alternative TSS	0	0	1.2
Eye	gene expression	0	0	1.13
Eye	isoform ratio	0	0	0.95
Eye	intron excision ratio	0	0	1.15
Eye	mRNA stability	0	0	1.25
IL	alternative polyA	0	0	1.21
IL	alternative TSS	0	0	1.01
IL	gene expression	0	0	1.06
IL	isoform ratio	0	0	1.13
IL	intron excision ratio	0	0	0.95
IL	mRNA stability	0	0	1.11
LHb	alternative polyA	0	0	1.13
LHb	alternative TSS	0	0	1.03
LHb	gene expression	0	0	1.05
LHb	isoform ratio	0	0	1.09
LHb	intron excision ratio	0	0	0.89
LHb	mRNA stability	0	0	1.1
Liver	alternative polyA	0	0	1.09
Liver	alternative TSS	0	0	1.04
Liver	gene expression	0	0	1.09
Liver	isoform ratio	0	0	1.03
Liver	intron excision ratio	0	0	1.03
Liver	mRNA stability	0	0	1.08
NAcc	alternative polyA	1	0	1.15
NAcc	alternative TSS	0	0	1.16
NAcc	gene expression	0	0	1.08
NAcc	isoform ratio	0	0	1.1
NAcc	intron excision ratio	0	0	1.04
NAcc	mRNA stability	0	0	1.1
OFC	alternative polyA	0	0	1.27
OFC	alternative TSS	0	0	1.16
OFC	gene expression	0	0	1.03
OFC	isoform ratio	0	0	1.13
OFC	intron excision ratio	0	0	0.99
OFC	mRNA stability	0	0	1.08
PL	alternative polyA	0	0	1.18
PL	alternative TSS	0	0	1.11
PL	gene expression	0	0	1.08
PL	isoform ratio	0	0	1.09
PL	intron excision ratio	0	0	1.07
PL	mRNA stability	0	0	1.13
pVTA	alternative polyA	0	0	1.15
pVTA	alternative TSS	0	0	1.18
pVTA	gene expression	0	0	1.08
pVTA	isoform ratio	0	0	1.1
pVTA	intron excision ratio	1	0	1.04
pVTA	mRNA stability	0	0	1.12
RMTg	alternative polyA	1	0.2	1.17
RMTg	alternative TSS	0	0	1.08
RMTg	gene expression	0	0	1.08
RMTg	isoform ratio	0	0	1.14
RMTg	intron excision ratio	0	0	1.01
RMTg	mRNA stability	0	0	1.06