Hub : Genes

Pde2a

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 BLA mRNA stability Pde2a 0.15 0.11 6.9e-04 0.02 0.04 0.03 0.03 1.8e-02 2.3e-03 1.6e-02 7.8e-03
2 Brain mRNA stability Pde2a 0.09 0.04 9.1e-11 0.11 0.12 0.11 0.1 2.6e-10 5.6e-11 2.9e-10 7.0e-10
3 Liver gene expression Pde2a 0.04 0.03 1.1e-04 0.02 0.02 0.02 0.02 1.9e-03 3.1e-03 1.3e-03 4.1e-03
4 IL mRNA stability Pde2a 0.3 0.15 6.6e-05 0.09 0.11 0.04 0.07 3.9e-03 1.2e-03 4.2e-02 7.2e-03
5 NAcc mRNA stability Pde2a 0.03 0.02 8.4e-04 0.02 0.02 0.01 0.02 4.4e-03 8.9e-04 5.7e-03 1.4e-03
6 Brain gene expression Pde2a 0.1 0.06 1.7e-07 0.05 0.08 0.06 0.07 9.2e-06 9.2e-08 1.3e-06 6.3e-07
7 Brain alternative TSS NM_001270604.2 0.04 0.03 7.4e-03 0.01 0.02 0.01 0.01 3.5e-02 1.1e-02 3.1e-02 2.6e-02
8 Brain alternative TSS NM_001143847.2 0.04 0.03 5.8e-03 0.01 0.02 0.01 0.01 1.8e-02 7.5e-03 2.2e-02 2.9e-02
9 OFC mRNA stability Pde2a 0.19 0.13 8.9e-03 0.11 0.05 0.03 0.08 1.2e-03 2.7e-02 5.3e-02 6.8e-03
10 Brain isoform ratio NM_001143847.2 0.05 0.03 2.8e-03 0 0.02 0.01 0.01 1.0e-01 9.8e-03 2.6e-02 3.2e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10
Bone: apparent density0.20.30.8-0.6-0.20.6-0.00.00.5-0.90.80.20.7
Area under the delay curve0.50.51.1-1.0-1.1-0.4-1.0-1.0-0.60.2-0.20.3-0.5
BMI with tail0.51.66.71.10.7-0.61.11.11.7-0.80.9-2.60.9
BMI without tail0.40.92.21.51.0-0.20.50.7-0.41.4-1.3-0.0-0.9
Body weight0.62.66.70.80.0-1.1-0.5-0.5-1.92.6-2.51.2-2.3
Weight adjusted by age0.40.51.10.90.7-0.00.20.3-0.61.1-1.00.8-0.7
Bone surface0.30.62.70.40.51.20.30.3-0.80.4-0.41.6-0.1
Bone volume0.30.52.70.20.20.80.10.0-0.80.4-0.51.7-0.3
Breakpoint value in progressive ratio session0.40.51.10.30.4-0.10.60.50.9-0.70.8-1.10.8
Number of licking bursts1.92.35.1-2.1-2.2-2.3-2.0-1.90.2-0.10.0-0.5-0.7
Context. condit. distance diff. score1.92.35.32.22.31.92.12.00.4-0.00.1-0.40.8
Locomotion velocity, session 11.31.42.80.10.40.40.80.81.7-1.61.6-1.41.5
Locomotion distance, session 11.41.83.01.41.61.51.71.71.1-0.91.0-0.61.3
Locomotion velocity, session 20.60.71.21.01.00.61.11.10.8-0.40.5-1.00.7
Locomotion distance, session 20.71.02.11.41.30.71.51.40.8-0.30.5-0.70.7
Locomotion velocity, session 30.40.51.40.70.91.20.90.80.2-0.30.30.60.6
Locomotion distance, session 31.21.43.60.91.31.91.31.40.7-0.90.9-0.41.3
Stereotopy head waving bouts, day 30.70.81.5-0.5-0.8-1.0-0.9-0.9-1.01.0-1.10.6-1.2
Stereotopy head waving duration, day 30.20.20.40.60.60.40.60.60.3-0.20.2-0.30.4
Locomotion velocity, session 70.30.31.00.20.30.00.50.51.0-0.70.7-0.50.7
Locomotion distance, session 70.20.30.7-0.5-0.6-0.8-0.6-0.6-0.20.3-0.30.5-0.5
Stereotopy head waving bouts, day 71.92.26.71.72.02.61.81.90.2-0.30.30.41.0
Stereotopy head waving duration, day 72.22.67.22.02.22.72.02.10.3-0.20.30.11.1
Locomotion velocity, session 80.60.71.71.21.31.21.11.1-0.20.3-0.20.60.2
Locomotion distance, session 81.92.86.82.62.51.82.42.30.30.20.0-0.70.7
Degree of sensitization distance2.92.95.2-0.5-1.2-2.2-1.5-1.6-1.72.0-2.01.1-2.3
Degree of sensitization stereotypy3.64.011.42.42.83.42.52.60.2-0.20.30.61.2
Conditioned locomotion0.81.01.7-0.9-1.1-1.3-1.0-1.3-1.10.7-0.70.6-1.0
Cocaine response after cond. corrected0.70.82.4-1.1-1.2-1.6-1.2-1.10.00.1-0.2-0.2-0.6
Cocaine response after cond. not corrected0.20.30.7-0.4-0.4-0.5-0.2-0.10.8-0.60.6-0.80.4
Cocaine response before conditioning2.83.45.61.62.12.42.22.21.6-1.41.5-1.12.0
Saline control response1.51.94.60.90.70.80.20.1-2.01.8-1.82.2-1.3
Bone: connectivity density1.22.03.70.10.71.41.01.11.8-1.81.8-1.11.9
Bone: cortical apparent density1.82.35.4-1.4-1.8-2.3-1.8-1.9-0.90.9-1.01.1-1.5
Bone: cortical area0.60.92.20.50.1-0.1-0.1-0.2-1.31.3-1.31.5-1.1
Bone: cortical porosity0.20.21.0-0.10.21.00.20.2-0.1-0.50.50.30.6
Bone: cortical porosity0.20.20.7-0.20.10.80.20.1-0.2-0.40.40.50.4
Bone: cortical thickness0.00.10.20.1-0.1-0.50.10.00.3-0.20.2-0.40.1
Bone: cortical thickness0.00.00.10.20.0-0.10.1-0.0-0.30.2-0.2-0.1-0.2
Bone: cortical tissue density1.72.25.4-1.4-1.8-2.3-1.8-1.8-0.80.9-0.91.0-1.4
Condit. Reinf. active minus inactive responses1.11.34.80.0-0.2-0.3-0.6-0.5-1.41.4-1.42.2-1.3
Condit. Reinf. active-inactive response ratio1.71.86.7-0.1-0.30.0-0.8-0.7-1.81.5-1.62.6-1.4
Condit. Reinf. active responses1.01.23.6-0.5-0.7-0.6-0.9-0.9-1.41.1-1.11.9-1.2
Condit. Reinf. inactive responses0.10.10.4-0.4-0.5-0.6-0.3-0.4-0.1-0.10.1-0.2-0.2
Incentive salience index mean0.81.03.5-0.2-0.4-0.1-0.6-0.6-1.41.1-1.11.9-1.1
Condit. Reinf. lever presses0.00.10.3-0.1-0.10.5-0.0-0.0-0.3-0.00.00.5-0.0
Condit. Reinf. active minus inactive responses3.44.27.52.72.42.31.71.7-1.92.1-2.02.1-1.0
Condit. Reinf. active-inactive response ratio0.90.92.11.41.41.41.21.2-0.20.3-0.30.60.2
Condit. Reinf. active responses4.46.19.83.12.62.31.71.7-2.72.9-2.82.6-1.6
Condit. Reinf. inactive responses2.83.56.72.01.41.20.80.7-2.52.6-2.51.9-1.8
Condit. Reinf. lever presses7.09.522.04.74.33.93.53.4-1.82.2-2.01.9-0.4
Condit. Reinf. lever reinforcers received4.56.411.03.32.92.72.02.0-2.62.8-2.62.5-1.4
Conditioned reinforcement - actives0.60.61.40.70.81.21.00.90.2-0.60.6-0.10.8
Conditioned reinforcement - inactives0.81.01.5-1.0-1.2-1.2-1.1-1.2-1.00.6-0.70.7-1.0
Conditioned locomotion2.02.44.51.61.82.12.01.90.9-1.01.1-0.71.5
Patch foraging indifference point 0 sec1.11.84.22.01.91.91.71.6-0.30.4-0.30.30.3
Patch foraging indifference point AUC0.50.61.40.30.0-0.5-0.3-0.3-0.91.2-1.20.8-1.0
Delay disc. indifference point, 0s delay0.30.30.70.80.60.70.50.4-0.60.6-0.60.4-0.4
Delay disc. indifference point, 16s delay1.01.01.9-1.3-1.3-0.6-1.3-1.4-0.90.3-0.40.9-0.7
Delay disc. indifference point, 2s delay0.50.61.60.10.00.5-0.2-0.2-1.31.0-1.01.1-0.8
Delay disc. indifference point, 24s delay1.41.42.9-1.6-1.7-1.5-1.5-1.7-0.60.1-0.20.3-0.8
Delay disc. indifference point, 4s delay0.90.92.20.40.1-0.0-0.2-0.2-1.51.5-1.51.0-1.3
Delay disc. indifference point, 8s delay0.10.10.4-0.6-0.6-0.3-0.5-0.5-0.2-0.10.1-0.1-0.1
Indifference point function ln k0.81.02.30.50.81.51.11.00.8-1.21.2-0.11.3
Indifference point function log k0.81.02.30.50.81.51.11.00.8-1.21.2-0.11.3
Patch foraging total patch changes 0 sec0.91.53.82.01.81.71.61.6-0.20.4-0.30.10.3
Patch foraging total patch changes 12 sec0.91.22.90.90.50.00.10.0-1.51.7-1.60.9-1.3
Patch foraging total patch changes 18 sec0.40.51.21.10.90.80.70.7-0.60.7-0.60.4-0.3
Patch foraging total patch changes 24 sec0.91.12.41.00.60.20.10.1-1.31.6-1.51.3-1.2
Patch foraging total patch changes 6 sec0.20.31.01.00.90.40.80.80.00.2-0.1-0.10.1
Patch foraging time to switch 0 sec1.62.56.2-2.5-2.3-1.9-1.9-1.90.6-1.00.8-1.10.0
Patch foraging water rate 0 sec1.11.84.22.01.91.71.71.6-0.30.5-0.41.00.2
Patch foraging water rate 12 sec2.43.67.42.72.61.92.62.61.3-0.50.7-1.01.3
Patch foraging water rate 18 sec1.62.26.22.52.31.31.92.00.10.7-0.50.30.2
Patch foraging water rate 24 sec1.11.52.51.21.31.11.61.41.1-1.01.1-0.81.3
Patch foraging water rate 6 sec1.11.63.21.71.71.21.81.70.8-0.50.6-0.21.0
Seeking ratio, delayed vs. immediate footshock1.01.12.4-1.2-0.8-0.5-0.4-0.31.3-1.51.5-1.11.1
Distance traveled before self-admin0.40.41.5-0.5-0.6-1.2-0.5-0.50.7-0.20.2-1.1-0.0
Distance traveled after self-admin0.60.71.10.60.80.40.90.91.0-0.80.8-0.80.9
Extensor digitorum longus weight0.10.30.9-0.1-0.4-0.9-0.5-0.4-0.20.6-0.6-0.3-0.7
Bone: elastic displacement1.31.43.3-0.9-0.5-0.3-0.1-0.01.7-1.71.6-1.81.3
Bone: elastic work2.53.27.0-0.8-0.3-0.00.30.42.6-2.52.5-2.62.1
Bone: endosteal estimation1.02.26.50.60.30.5-0.3-0.2-2.11.9-1.92.6-1.6
Bone: endosteal perimeter1.02.04.81.10.81.00.20.3-1.91.8-1.82.2-1.3
Epididymis fat weight0.41.02.7-0.6-1.0-1.6-1.2-1.1-0.51.0-1.0-0.0-1.3
Delta time in closed arm before/after self-admin2.92.95.4-1.1-1.7-2.3-1.9-1.9-1.31.6-1.70.7-2.0
Delta time in open arm before/after self-admin1.01.02.71.01.11.70.80.8-1.00.6-0.61.5-0.1
Diff in mean of infusions in LGA sessions2.02.24.6-2.1-2.0-1.4-2.1-2.0-1.00.5-0.60.8-1.1
Delay discount exponential model param0.40.41.11.01.10.40.90.90.4-0.00.1-0.10.4
Extinction: sum of active levers before priming0.00.00.2-0.2-0.2-0.5-0.1-0.10.1-0.10.1-0.30.0
Active lever presses in extinction session 62.62.64.51.41.82.12.01.91.2-1.31.3-0.71.8
Bone: final force1.42.34.7-1.2-1.4-1.2-1.5-1.7-1.71.1-1.22.2-1.5
Bone: final moment1.11.94.1-0.9-1.1-1.0-1.3-1.4-1.71.2-1.22.0-1.5
Food consumed during 24 hour testing period2.32.77.21.92.22.72.12.20.4-0.50.6-0.21.2
Glucose0.50.81.20.50.80.70.91.01.1-0.91.0-0.81.1
Heart weight0.50.72.01.01.11.41.01.0-0.10.1-0.00.50.3
Delay discount hyperbolic model param0.40.40.80.80.90.30.90.80.6-0.30.3-0.20.5
Intermittent access intake day 1-15 change2.01.93.31.61.71.21.81.81.2-0.70.8-1.41.2
Intermittent access intake escalation2.02.03.31.51.61.31.81.81.2-0.91.0-1.41.3
Intermittent access intake escalation 20.20.20.70.60.3-0.10.50.50.4-0.00.1-0.80.1
Intermitt. access day 1 inactive lever presses1.41.53.1-1.5-1.8-1.3-1.6-1.7-1.00.4-0.50.5-1.0
Intermitt. access day 15 inactive lever presses0.20.20.40.40.50.50.60.50.0-0.30.30.10.4
Intermitt. access escalation Index0.10.10.3-0.1-0.20.2-0.2-0.2-0.50.3-0.30.5-0.3
Intermittent access day 1 total infusions0.50.61.80.50.50.70.30.2-1.10.8-0.81.3-0.5
Intermittent access day 15 total infusions0.50.61.21.11.01.01.10.9-0.40.1-0.10.30.3
Intermittent access terminal intake (last 3 days)0.40.40.90.90.80.80.80.7-0.60.4-0.40.5-0.1
Intermittent access total infusions0.30.30.60.60.50.60.50.4-0.80.5-0.40.7-0.2
Intermittent access day 1 locomotion0.10.10.4-0.4-0.30.4-0.2-0.2-0.4-0.20.10.60.1
Intermittent access day 15 total locomotion1.21.32.81.11.31.71.51.40.6-0.80.9-0.51.2
Intermittent access total locomotion0.30.40.90.80.81.00.80.7-0.2-0.00.10.20.3
Intermittent access standard deviation0.20.21.00.50.3-0.10.50.50.4-0.20.3-1.00.3
Left kidney weight0.51.53.51.71.1-0.10.60.7-1.11.9-1.70.9-1.2
Right kidney weight0.41.12.91.00.5-0.50.10.1-1.21.7-1.61.0-1.4
Cocaine induced anxiety2.12.45.4-2.3-2.3-2.0-2.0-2.1-0.3-0.20.10.0-0.6
Post-drug Anxiety1.82.13.1-1.5-1.6-1.4-1.8-1.7-1.31.0-1.11.4-1.4
Baseline Anxiety0.91.02.21.00.91.10.50.6-1.11.1-1.11.5-0.6
Tail length3.811.625.01.50.70.1-0.9-0.6-4.65.0-5.04.9-4.1
Length with tail2.910.622.10.7-0.2-0.8-1.4-1.3-4.54.7-4.74.3-4.2
Length without tail0.20.30.6-0.6-0.7-0.6-0.6-0.8-0.60.4-0.40.4-0.6
Times rat made contact with spout0.40.40.6-0.6-0.7-0.5-0.8-0.7-0.70.6-0.60.6-0.8
Lifetime Intake0.50.51.11.01.01.00.80.8-0.60.4-0.40.6-0.0
Liver weight, left3.55.68.2-2.1-2.6-2.4-2.9-2.8-2.31.8-2.01.9-2.5
Liver weight, right5.59.112.2-2.2-2.9-3.0-3.4-3.3-3.12.8-2.92.8-3.5
Locomotor activity0.30.41.51.21.00.40.90.8-0.00.4-0.3-0.10.0
Locomotor testing distance1.01.64.72.21.81.01.51.4-0.61.1-0.90.5-0.3
Locomotor testing rearing0.81.33.11.00.60.10.10.1-1.41.8-1.71.3-1.4
Locomotion in novel chamber1.31.63.00.30.40.61.00.81.6-1.61.7-1.71.6
Locomotion in novel chamber post-restriction1.62.05.01.21.52.21.71.70.8-1.11.1-0.41.5
Fecal boli incidents, locomotor time 10.60.71.6-1.3-1.10.2-0.6-0.70.1-1.11.0-0.40.6
Change in fecal boli incidents, locomotor task0.20.10.60.0-0.0-0.8-0.3-0.20.10.4-0.40.5-0.4
Time >=10cm from walls, locomotor time 10.20.20.80.50.50.70.40.3-0.40.1-0.10.90.1
Bouts of movement, locomotor time 10.20.30.7-0.5-0.40.2-0.5-0.5-0.80.3-0.40.8-0.4
Total resting periods, locomotor time 10.10.10.3-0.6-0.40.2-0.3-0.4-0.2-0.30.30.20.1
Rest time, locomotor task time 10.10.10.5-0.6-0.30.0-0.4-0.4-0.3-0.20.10.70.0
Distance moved, locomotor task time 10.10.10.30.40.2-0.30.10.1-0.20.6-0.5-0.2-0.5
Vertical activity count, locomotor time 10.30.30.70.1-0.3-0.4-0.3-0.3-0.80.8-0.80.4-0.8
Time >=10cm from walls, locomotor time 21.61.75.20.90.60.30.1-0.0-1.81.7-1.72.3-1.3
Bouts of movement, locomotor time 23.13.35.8-0.8-1.2-1.3-1.6-1.7-2.42.1-2.12.0-2.3
Total resting periods, locomotor time 22.72.84.3-1.0-1.4-1.4-1.7-1.8-2.11.7-1.81.5-2.0
Rest time, locomotor task time 21.01.22.2-1.5-1.4-1.5-1.1-1.10.7-0.80.7-1.10.2
Distance moved, locomotor task time 21.31.53.21.81.51.11.11.1-1.11.3-1.21.2-0.6
Vertical activity count, locomotor time 21.11.22.80.2-0.2-0.3-0.5-0.5-1.71.5-1.51.4-1.4
Light reinforcement 10.71.32.7-1.1-1.1-1.6-0.7-0.61.6-1.11.1-1.30.6
Light reinforcement 22.63.57.00.91.30.71.71.82.7-1.92.0-2.52.2
Bone: marrow area1.02.16.20.40.10.4-0.4-0.3-2.11.9-1.92.5-1.6
Bone: maximum diameter1.01.94.41.31.01.00.50.5-1.81.8-1.72.1-1.2
Bone: maximum force0.71.34.1-0.8-0.9-0.6-1.0-1.1-1.40.9-0.92.0-1.1
Bone: maximum moment0.50.82.8-0.4-0.5-0.3-0.7-0.7-1.20.8-0.81.7-0.9
Mean time between licks in bursts4.15.713.21.70.90.1-0.1-0.1-3.43.6-3.52.7-2.9
Mean num. licks in bursts1.51.84.31.91.92.11.71.6-0.40.3-0.20.80.4
Cd content in liver0.30.30.8-0.9-0.9-0.5-0.9-0.7-0.10.1-0.1-0.1-0.3
Co content in liver1.72.05.10.40.10.3-0.4-0.4-2.31.9-1.91.9-1.6
Cu content in liver1.01.22.70.20.00.2-0.4-0.3-1.61.5-1.51.6-1.3
Fe content in liver0.40.40.7-0.8-0.8-0.2-0.9-0.8-0.80.4-0.50.5-0.6
K content in liver0.40.41.0-0.5-0.8-1.0-0.6-0.7-0.50.4-0.4-0.5-0.7
Mg content in liver0.10.10.20.40.30.20.30.3-0.10.1-0.1-0.4-0.0
Mn content in liver1.11.32.6-1.0-0.7-0.5-0.2-0.31.5-1.61.6-1.51.2
Na content in liver0.30.41.60.40.61.20.60.70.1-0.40.4-0.10.6
Rb content in liver0.20.31.10.30.31.00.20.2-0.80.4-0.40.8-0.2
Se content in liver1.72.05.5-2.3-2.1-1.3-1.6-1.60.7-1.21.1-0.70.3
Sr content in liver2.32.13.71.11.31.01.51.51.8-1.21.3-1.91.6
Zn content in liver2.22.55.62.42.32.02.12.10.30.10.1-0.50.8
Bone: minimum diameter1.63.16.30.2-0.3-0.7-0.9-0.9-2.52.5-2.52.1-2.3
Time in familiar zone, hab. session 10.10.10.30.50.4-0.10.20.3-0.20.5-0.5-0.2-0.3
Time in novel zone, hab. session 10.40.40.8-0.9-0.9-0.6-0.9-0.8-0.20.0-0.10.8-0.3
Total zone transitions, hab. session 10.71.01.80.60.91.41.01.11.0-1.01.0-0.41.2
Total locomotion distance, hab. session 11.62.33.8-0.6-1.0-1.9-1.4-1.4-1.41.7-1.81.3-1.9
Locomotion velocity, hab. session 11.21.72.9-0.4-0.9-1.7-1.1-1.1-1.31.5-1.51.0-1.7
Time in familiar zone, hab. session 21.11.13.21.00.80.30.30.2-1.21.4-1.31.8-0.9
Time in novel zone, hab. session 21.21.23.5-0.00.10.20.60.51.5-1.41.4-1.91.2
Total zone transitions, hab. session 21.92.55.02.02.22.22.12.10.6-0.40.5-0.11.1
Total locomotion distance, hab. session 21.72.35.40.7-0.0-1.4-0.5-0.6-1.82.3-2.21.4-2.1
Locomotion velocity, hab. session 21.92.66.00.6-0.2-1.6-0.6-0.8-1.92.4-2.41.3-2.3
Novel to familiar place preference ratio1.51.63.3-0.7-0.9-0.8-1.1-1.3-1.81.3-1.31.5-1.5
Novelty place preference1.41.53.1-0.6-0.8-0.8-1.0-1.2-1.81.3-1.31.4-1.4
Time in novel zone, NPP test1.51.53.4-0.4-0.7-0.7-0.9-1.1-1.91.4-1.41.5-1.5
Total zone transitions, NPP test1.41.92.71.11.31.41.61.61.4-1.21.3-1.31.5
Total locomotion distance, NPP test0.50.62.30.4-0.2-1.5-0.3-0.3-0.31.1-1.0-0.4-1.1
Locomotion velocity, NPP test0.40.62.60.2-0.4-1.6-0.4-0.4-0.10.8-0.8-0.6-0.9
Intraocular pressure1.31.84.0-0.00.61.20.81.01.7-1.91.9-0.62.0
Delta distance traveled before/after self-admin0.91.03.00.91.11.50.80.7-1.00.6-0.61.7-0.1
Delta ambulatory time before/after self-admin0.80.92.80.91.21.71.11.0-0.40.0-0.01.20.4
Parametrial fat weight0.20.42.0-0.2-0.3-0.6-0.20.01.0-0.40.4-1.40.3
Pavlov. Cond. lever latency0.30.41.1-0.5-0.5-1.1-0.3-0.30.9-0.60.6-0.70.3
Pavlov. Cond. magazine entry latency1.31.73.92.01.81.61.41.4-0.81.1-1.00.5-0.3
Pavlov. Cond. change in total contacts0.60.71.90.40.41.00.10.1-1.30.9-0.91.4-0.6
Pavlov. Cond. index score1.01.23.01.51.41.71.11.1-1.00.9-0.80.7-0.3
Pavlov. Cond. latency score0.91.12.61.31.21.60.90.9-1.10.9-0.90.8-0.4
Pavlov. Cond. lever contacts0.30.41.20.60.61.10.40.4-0.80.6-0.60.5-0.3
Pavlov. Cond. magazine entry number1.31.74.4-1.8-1.8-2.1-1.5-1.50.6-0.60.5-0.6-0.1
Pavlov. Cond. intertrial magazine entries0.50.61.5-1.2-1.1-0.9-0.9-1.00.0-0.30.20.5-0.1
Pavlov. Cond. lever-magazine prob. diff.0.81.02.91.31.31.71.01.0-0.80.7-0.60.5-0.1
Pavlov. Cond. response bias0.40.51.21.00.91.10.70.7-0.70.7-0.60.4-0.2
Pavlov. Cond. lever latency8.211.027.8-5.3-4.9-4.1-4.1-4.01.2-1.91.6-1.1-0.1
Pavlov. Cond. magazine entry latency4.55.110.73.33.22.33.13.11.1-0.30.5-1.61.4
Pavlov. Cond. change in total contacts7.710.625.75.14.94.24.24.2-0.71.4-1.10.50.5
Pavlov. Cond. index score7.09.023.34.84.53.63.93.9-0.61.3-1.00.20.5
Pavlov. Cond. latency score6.98.621.74.74.43.53.93.9-0.21.0-0.7-0.10.7
Pavlov. Cond. lever contacts8.211.227.55.24.94.24.14.0-1.41.9-1.71.30.0
Pavlov. Cond. magazine entry number5.66.914.9-3.9-3.8-3.1-3.6-3.6-0.70.0-0.21.1-1.4
Pavlov. Cond. intertrial magazine entries1.31.73.1-0.5-0.8-0.6-1.2-1.1-1.81.6-1.61.5-1.6
Pavlov. Cond. lever-magazine prob. diff.6.68.422.14.74.43.43.83.7-0.61.4-1.10.10.3
Pavlov. Cond. response bias9.012.230.65.55.24.44.54.4-1.01.6-1.40.70.4
Time in closed arm before self-admin2.52.85.21.92.22.12.32.11.0-0.91.0-0.51.6
Time in closed arm after self-admin0.30.30.6-0.8-0.7-0.7-0.5-0.60.3-0.50.4-0.40.1
Time in open arm before self-admin2.42.65.7-2.2-2.3-2.4-1.9-1.80.7-0.70.6-1.5-0.2
Time in open arm after self-admin0.30.30.6-0.2-0.4-0.4-0.6-0.5-0.70.7-0.70.6-0.7
Bone: periosteal estimation0.91.85.00.60.30.4-0.2-0.1-1.91.8-1.82.2-1.4
Bone: periosteal perimeter0.81.32.61.10.80.70.40.4-1.51.5-1.41.6-1.0
Bone: post-yield work0.10.21.20.40.30.10.20.1-0.30.4-0.31.1-0.2
Progressive ratio test 1 active lever presses0.00.00.1-0.00.10.20.10.1-0.0-0.00.00.20.1
Progressive ratio test 1 breakpoint0.00.00.1-0.10.00.1-0.1-0.0-0.20.1-0.10.3-0.1
Progressive ratio test 1 inactive lever presses0.10.10.20.10.00.40.10.0-0.40.1-0.10.4-0.1
Progressive ratio test 2 active lever presses0.30.31.10.20.10.50.0-0.0-1.10.6-0.61.0-0.5
Progressive ratio test 2 breakpoint0.40.41.30.20.10.50.0-0.0-1.10.7-0.71.1-0.6
Progressive ratio test 2 inactive lever presses0.10.10.40.30.30.60.50.3-0.4-0.20.20.30.3
Incentive Sensitization - Responses0.70.72.00.60.30.60.20.1-1.41.0-1.01.2-0.8
Incentive Sensitization - Breakpoint0.50.51.20.70.50.70.40.3-1.10.8-0.80.9-0.5
Sum of active levers in priming session hrs 5-60.20.20.30.50.6-0.00.60.50.3-0.10.1-0.30.2
Progressive ratio0.60.71.10.40.60.80.80.81.0-1.01.0-0.91.1
Food seeking constrained by brief footshock0.91.12.11.10.90.60.40.5-1.21.5-1.41.2-1.0
Seeking ratio, punishment vs. effort1.31.63.70.60.1-0.4-0.3-0.3-1.71.9-1.91.5-1.7
Retroperitoneal fat weight2.27.114.6-1.5-2.5-3.8-2.9-2.7-1.92.8-2.90.5-3.4
Reaction time number correct0.40.51.10.30.40.30.70.60.7-0.90.9-1.10.9
Reaction time mean minus median0.30.40.90.60.30.30.10.0-0.90.9-0.90.5-0.7
Reaction time mean minus median AUC0.20.20.40.60.40.50.40.3-0.70.5-0.50.3-0.3
Reaction time num false alarms2.23.06.1-2.1-2.4-2.5-2.2-2.3-0.80.6-0.70.3-1.4
Reaction time num false alarms AUC1.62.14.6-1.9-2.1-2.1-1.9-2.0-0.60.2-0.3-0.1-1.0
Reaction time trials correct on left0.40.51.10.30.40.30.70.60.7-0.90.9-1.10.9
Reaction time trials on left0.40.61.40.30.40.30.70.60.8-0.90.9-1.20.9
Reaction time mean1.92.74.7-1.7-2.1-2.0-2.1-2.2-1.31.0-1.10.4-1.7
Reaction time mean AUC1.92.54.6-1.9-2.2-1.9-2.1-2.1-1.10.7-0.80.4-1.4
Median of all reaction times2.23.15.8-2.1-2.4-2.3-2.3-2.4-1.10.7-0.80.1-1.5
Reaction time omissions0.40.51.8-0.5-0.8-1.2-0.6-0.6-0.10.1-0.1-1.4-0.4
Reaction time false alarm rate1.72.34.8-1.8-2.1-2.2-2.0-2.0-0.70.6-0.70.3-1.3
Reaction time premature initiation rate1.21.64.11.20.70.50.10.2-1.52.0-2.01.3-1.5
Reaction time premature initiations0.50.71.41.20.90.70.50.6-0.81.1-1.00.2-0.7
Std. dev. reaction times1.52.13.7-0.6-1.1-1.0-1.3-1.4-1.91.7-1.71.1-1.9
Reaction time trials completed0.40.61.40.30.40.30.70.60.8-0.90.9-1.20.9
Reaction time trials AUC0.20.30.90.30.30.10.60.40.5-0.60.6-0.90.6
Run reversals in cocaine runway, females1.31.33.60.60.1-1.1-0.4-0.3-1.01.9-1.80.5-1.7
Run reversals in cocaine runway, males0.20.20.6-0.8-0.6-0.0-0.4-0.40.2-0.60.5-0.20.3
Latency to leave start box in cocaine runway0.70.71.7-1.3-1.2-0.9-1.3-1.1-0.00.1-0.1-0.1-0.5
Latency to leave start box in cocaine runway, F1.21.32.5-1.3-1.4-1.1-1.6-1.4-0.80.8-0.80.6-1.1
Latency to leave start box in cocaine runway, M0.60.61.3-0.6-0.30.2-0.1-0.01.0-1.11.1-0.90.9
Std. dev. time between licks in bursts2.73.36.60.4-0.2-0.8-0.8-0.8-2.42.6-2.52.4-2.4
Total sessions with >9 infusions2.72.95.82.32.42.22.32.30.6-0.40.6-0.31.3
Short access day 1 total inactive lever presses0.50.61.3-1.2-1.1-0.4-0.9-1.0-0.80.0-0.10.7-0.4
Short access day 10 total inactive lever presses0.30.40.9-0.9-0.9-0.7-0.6-0.70.1-0.40.4-0.40.0
Short access day 1 total infusions0.80.81.51.21.11.00.90.8-0.90.8-0.71.0-0.3
Short access day 10 total infusions0.60.71.21.11.01.10.70.7-0.90.7-0.70.9-0.3
Short access total infusions0.60.61.41.21.11.00.90.8-0.60.6-0.50.6-0.1
Short access day 1 locomotion2.02.13.21.01.41.81.61.61.2-1.41.5-0.91.8
Short access day 10 total locomotion0.20.20.50.70.50.30.60.50.00.1-0.0-0.70.1
Short access total locomotion0.20.20.40.30.40.70.60.60.3-0.50.5-0.40.6
One hour access (0.3 mA shock)0.60.72.11.51.20.91.21.1-0.20.4-0.3-0.10.1
Compulsive drug intake0.70.71.7-0.6-0.30.00.10.11.1-1.31.3-0.81.1
One hour access (shock baseline)0.70.81.61.30.90.70.70.6-1.11.1-1.00.7-0.7
Social response proportion0.50.51.8-0.2-0.7-1.3-0.6-0.7-0.40.7-0.6-0.7-0.9
Social responses1.72.24.2-0.4-1.1-2.1-1.2-1.4-1.61.8-1.70.6-2.0
Social time0.81.01.9-1.4-1.3-1.4-0.9-1.00.7-0.80.7-1.10.2
Soleus weight0.92.74.9-0.6-1.3-1.9-1.6-1.5-1.72.0-2.00.9-2.2
Bone: stiffness3.04.87.7-1.7-2.0-1.9-2.3-2.4-2.41.8-1.92.8-2.3
Tibialis anterior weight0.31.12.00.1-0.3-0.7-0.6-0.6-1.31.4-1.41.2-1.4
Time to tail flick, vehicle, before self-admin0.10.10.30.40.50.50.50.4-0.10.1-0.10.30.1
Time to tail flick, vehicle, after self-admin1.21.34.51.01.42.11.31.3-0.0-0.40.40.60.9
Time to tail flick, test, before self-admin0.70.71.80.70.71.10.30.5-0.90.9-0.91.4-0.5
Time to tail flick, test, after self-admin2.02.14.60.30.0-0.1-0.6-0.5-2.02.0-2.02.1-1.8
Delta time to tail flick, vehicle, before/after SA0.70.71.90.50.81.40.80.90.4-0.80.8-0.11.0
Delta time to tail flick, test, before/after SA0.20.20.8-0.2-0.4-0.9-0.4-0.4-0.10.3-0.3-0.3-0.4
Tibia length0.30.93.80.91.11.91.21.0-0.5-0.20.20.80.6
Ambulatory time before self-admin0.50.51.3-0.7-0.7-1.1-0.5-0.50.8-0.50.5-1.00.2
Ambulatory time after self-admin0.50.50.90.50.80.70.90.80.8-0.70.8-0.20.9
Bone: tissue strength2.32.34.30.30.70.71.21.12.1-2.02.0-1.82.0
Total heroin consumption0.50.61.81.31.20.51.21.00.10.2-0.1-0.20.2
Bone: trabecular number0.61.02.4-0.9-0.50.3-0.1-0.01.3-1.51.5-0.81.2
Bone: trabecular spacing1.01.32.41.51.51.11.61.50.8-0.40.5-1.00.9
Bone: trabecular thickness1.92.24.2-1.2-1.3-1.1-1.6-1.6-1.71.2-1.32.1-1.6
Bone: trabecular tissue density5.88.210.9-2.1-2.7-2.9-3.1-3.2-3.12.6-2.72.7-3.3
Water consumed over 24 hours0.20.30.8-0.9-0.7-0.3-0.4-0.40.5-0.70.70.00.4
Number of responses in last shaping day0.80.91.9-0.6-0.7-0.3-0.8-0.9-1.30.9-0.91.4-1.0