Pde2a

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	NAcc	gene expression	Pde2a	0.05	0.03	7.9e-07	0.04	0.04	0.03	0.04	2.5e-07	1.5e-06	6.8e-06	3.4e-06
2	Liver	gene expression	Pde2a	0.06	0.04	2.4e-06	0.01	0.03	0.03	0.02	1.3e-02	2.8e-04	2.5e-04	1.1e-03
3	BLA	mRNA stability	Pde2a	0.16	0.12	3.9e-04	0.03	0.05	0.02	0.04	7.6e-03	1.6e-03	2.3e-02	3.6e-03
4	NAcc	mRNA stability	Pde2a	0.02	0.02	4.2e-04	0.03	0.02	0.02	0.03	3.5e-05	1.6e-04	3.8e-04	6.4e-05
5	Brain	mRNA stability	Pde2a	0.09	0.05	3.0e-10	0.12	0.11	0.11	0.12	1.8e-11	1.5e-10	4.7e-10	4.9e-11
6	IC	gene expression	Pde2a	0.19	0.11	1.0e-04	0.06	0.1	0.08	0.07	1.1e-03	7.5e-05	2.6e-04	5.3e-04
7	Brain	isoform ratio	NM_001143847.2	0.04	0.03	8.8e-03	0.03	0.01	0.02	0.02	1.2e-03	4.2e-02	7.8e-03	9.1e-03
8	Brain	gene expression	Pde2a	0.1	0.06	3.4e-07	0.05	0.06	0.06	0.06	1.5e-05	1.6e-06	2.8e-06	2.1e-06
9	IL	mRNA stability	Pde2a	0.28	0.16	2.3e-04	0.08	0.09	0.11	0.06	5.0e-03	3.8e-03	1.6e-03	1.5e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6	7	8	9
Bone: apparent density	0.2	0.4	1.1	-0.6	-0.0	-0.6	-0.3	-0.3	0.7	1.0	0.6	-0.8
Area under the delay curve	0.4	0.5	1.4	-0.0	0.6	-1.0	-1.2	-0.7	-0.0	-0.2	-0.6	-0.6
BMI with tail	0.5	1.8	5.4	0.2	0.9	2.0	1.6	0.2	0.8	-1.3	1.0	2.3
BMI without tail	0.7	2.1	7.8	1.1	-0.5	2.8	2.1	0.6	-0.7	-1.8	0.1	0.9
Body weight	0.5	2.0	8.2	1.0	0.5	1.6	0.6	-0.9	-1.7	-2.9	-1.5	0.4
Weight adjusted by age	0.2	0.3	0.6	0.3	-0.2	0.6	0.3	0.6	-0.8	-0.4	-0.4	-0.6
Bone surface	0.4	0.6	1.7	1.3	-1.2	0.2	-0.0	-0.0	-0.9	-0.3	-0.8	-1.1
Bone volume	0.2	0.3	0.6	0.8	-0.6	-0.0	-0.2	-0.3	-0.7	-0.4	-0.7	-0.7
Breakpoint value in progressive ratio session	0.4	0.5	1.2	-0.9	0.6	-0.5	-0.2	-0.1	0.9	0.4	0.7	1.1
Number of licking bursts	1.8	2.9	6.3	-2.5	2.5	-2.0	-1.7	-1.8	1.0	0.4	0.3	-1.4
Context. condit. distance diff. score	2.0	2.4	4.6	1.6	-2.0	2.1	2.1	2.1	-0.8	-0.3	0.2	1.0
Locomotion velocity, session 1	1.2	1.3	3.0	-0.9	-0.1	0.2	0.8	0.8	1.7	1.5	1.7	1.1
Locomotion distance, session 1	1.5	1.9	3.4	0.8	-1.6	1.5	1.8	1.8	0.6	0.5	1.0	1.8
Locomotion velocity, session 2	0.7	0.8	1.9	0.6	-0.8	1.2	1.2	1.1	0.6	0.0	0.7	1.4
Locomotion distance, session 2	1.2	1.7	5.8	0.8	-0.9	1.6	1.6	1.5	0.5	-0.2	0.8	2.4
Locomotion velocity, session 3	0.5	0.5	1.5	0.7	-1.2	0.7	0.9	1.0	-0.3	0.1	0.1	0.5
Locomotion distance, session 3	0.9	0.9	2.7	0.6	-1.6	0.9	1.2	1.3	0.1	0.9	0.7	0.2
Stereotopy head waving bouts, day 3	0.6	0.7	1.1	-0.1	0.8	-0.6	-0.9	-1.0	-0.7	-1.1	-1.0	-0.6
Stereotopy head waving duration, day 3	0.1	0.2	0.4	0.4	-0.5	0.6	0.6	0.5	-0.1	-0.2	0.2	0.4
Locomotion velocity, session 7	0.5	0.5	1.1	-0.8	0.1	0.3	0.7	0.8	0.9	0.8	1.1	0.5
Locomotion distance, session 7	0.1	0.2	0.8	-0.5	0.9	-0.5	-0.4	-0.4	0.1	-0.1	-0.1	0.0
Stereotopy head waving bouts, day 7	2.2	2.5	8.7	2.0	-2.9	1.7	1.6	1.8	-0.8	0.1	0.0	-0.0
Stereotopy head waving duration, day 7	2.2	2.6	8.3	2.1	-2.9	2.0	1.8	1.9	-0.7	-0.1	0.0	0.4
Locomotion velocity, session 8	0.9	1.1	2.4	1.5	-1.5	1.2	1.0	1.1	-0.9	-0.5	-0.3	0.5
Locomotion distance, session 8	2.6	3.8	7.1	1.8	-2.2	2.7	2.6	2.5	-0.6	-0.8	0.3	2.4
Degree of sensitization distance	1.6	1.6	3.9	-0.0	1.7	-0.6	-1.2	-1.4	-1.1	-2.0	-1.6	-0.1
Degree of sensitization stereotypy	3.7	4.0	12.1	2.6	-3.5	2.3	2.2	2.3	-1.2	-0.1	-0.1	0.2
Conditioned locomotion	0.7	0.8	1.4	-0.5	1.0	-1.0	-1.2	-1.1	-0.6	-0.9	-1.0	0.9
Cocaine response after cond. corrected	0.8	0.9	2.5	-1.3	1.6	-1.1	-0.9	-1.0	0.6	0.1	0.1	-0.8
Cocaine response after cond. not corrected	0.4	0.4	1.1	-0.8	0.7	-0.3	-0.0	-0.2	1.0	0.8	0.8	-0.4
Cocaine response before conditioning	1.9	2.3	4.4	1.1	-2.1	1.7	2.0	2.0	0.6	1.3	1.4	0.5
Saline control response	1.5	2.0	4.9	2.2	-1.5	0.7	-0.0	0.1	-2.0	-1.6	-1.8	-0.5
Bone: connectivity density	0.8	1.3	4.0	-0.3	-0.8	0.2	0.8	0.9	1.5	2.0	1.7	-0.4
Bone: cortical apparent density	1.1	1.5	4.3	-1.3	2.1	-1.4	-1.5	-1.6	0.2	-0.4	-0.3	-0.5
Bone: cortical area	0.3	0.5	1.4	1.1	-0.2	0.3	-0.1	-0.2	-0.8	-1.2	-0.9	0.1
Bone: cortical porosity	0.1	0.1	0.3	0.1	-0.4	-0.4	-0.4	-0.2	-0.1	0.4	-0.2	0.5
Bone: cortical porosity	0.1	0.1	0.5	0.3	-0.7	-0.2	-0.3	-0.0	-0.1	0.4	-0.2	0.3
Bone: cortical thickness	0.2	0.3	0.9	-0.4	0.6	-0.0	0.1	-0.0	0.9	0.2	0.7	0.8
Bone: cortical thickness	0.2	0.2	0.7	0.5	0.0	0.2	0.1	0.0	-0.3	-0.6	-0.4	0.8
Bone: cortical tissue density	1.1	1.5	4.3	-1.3	2.1	-1.4	-1.5	-1.6	0.3	-0.3	-0.2	-0.5
Condit. Reinf. active minus inactive responses	0.7	0.8	2.2	0.9	-0.0	-0.1	-0.4	-0.5	-1.5	-1.2	-1.4	-0.6
Condit. Reinf. active-inactive response ratio	1.3	1.4	3.4	1.1	-0.2	-0.3	-0.6	-0.7	-1.9	-1.2	-1.8	-1.3
Condit. Reinf. active responses	0.6	0.7	1.8	0.4	0.3	-0.6	-0.9	-0.9	-1.0	-1.2	-1.4	0.1
Condit. Reinf. inactive responses	0.3	0.3	2.1	-0.4	0.5	-0.3	-0.4	-0.4	0.5	-0.3	0.0	1.4
Incentive salience index mean	0.6	0.7	1.9	1.0	-0.1	-0.2	-0.5	-0.6	-1.1	-1.2	-1.4	0.1
Condit. Reinf. lever presses	0.2	0.3	1.1	0.9	-0.7	0.2	0.2	0.1	0.1	-0.2	-0.2	1.0
Condit. Reinf. active minus inactive responses	4.4	5.7	13.4	3.7	-3.0	2.5	1.6	1.6	-2.9	-2.4	-2.0	0.3
Condit. Reinf. active-inactive response ratio	0.8	1.0	2.6	1.3	-1.6	1.2	0.9	1.0	-0.7	-0.4	-0.3	0.0
Condit. Reinf. active responses	6.1	8.5	20.1	4.5	-3.2	2.8	1.6	1.6	-3.7	-3.3	-2.9	0.7
Condit. Reinf. inactive responses	4.0	5.1	12.1	3.5	-1.9	1.7	0.7	0.7	-3.0	-3.1	-2.7	1.1
Condit. Reinf. lever presses	10.2	14.1	33.1	5.8	-4.8	4.4	3.1	3.2	-3.4	-3.1	-2.2	2.3
Condit. Reinf. lever reinforcers received	6.7	9.4	22.9	4.8	-3.6	3.0	1.8	1.8	-3.7	-3.3	-2.8	1.0
Conditioned reinforcement - actives	0.3	0.5	1.2	1.0	-0.9	0.5	0.6	0.7	0.2	0.5	0.2	1.1
Conditioned reinforcement - inactives	0.5	0.8	2.1	-0.5	1.0	-1.4	-1.5	-1.1	0.0	0.0	-0.6	-0.3
Conditioned locomotion	1.8	2.3	5.2	1.2	-1.9	1.3	1.5	1.7	0.8	1.1	1.1	2.3
Patch foraging indifference point 0 sec	0.9	1.7	4.2	2.1	-1.9	1.9	1.3	0.5	-0.9	-0.8	-0.4	0.9
Patch foraging indifference point AUC	0.4	0.5	1.3	1.1	-0.1	0.4	0.2	-0.0	-0.9	-1.1	-0.8	-0.8
Delay disc. indifference point, 0s delay	0.9	1.0	2.4	1.5	-1.0	0.9	0.5	0.4	-0.9	-1.4	-0.8	0.7
Delay disc. indifference point, 16s delay	1.0	1.1	2.8	-0.6	1.0	-1.4	-1.7	-1.3	-0.4	-0.3	-0.9	-1.1
Delay disc. indifference point, 2s delay	0.6	0.7	1.6	1.2	-0.8	0.1	-0.3	0.2	-1.1	-1.2	-1.3	0.2
Delay disc. indifference point, 24s delay	1.4	1.5	3.4	-1.4	1.8	-1.8	-1.9	-1.2	0.2	-0.1	-0.5	-0.6
Delay disc. indifference point, 4s delay	1.2	1.3	3.3	1.5	-0.6	0.5	-0.2	-0.1	-1.6	-1.8	-1.7	0.0
Delay disc. indifference point, 8s delay	0.2	0.2	0.6	0.1	0.5	-0.7	-0.8	-0.4	0.2	0.3	-0.2	-0.2
Indifference point function ln k	0.4	0.7	1.7	0.0	-1.2	0.5	0.7	0.8	0.5	0.9	0.7	1.3
Indifference point function log k	0.4	0.7	1.7	0.0	-1.2	0.5	0.7	0.8	0.5	0.9	0.7	1.3
Patch foraging total patch changes 0 sec	0.8	1.6	3.8	1.9	-1.7	1.9	1.3	0.4	-0.7	-0.7	-0.3	0.7
Patch foraging total patch changes 12 sec	0.9	1.2	3.3	1.6	-0.3	0.8	0.2	-0.1	-1.5	-1.8	-1.4	-0.1
Patch foraging total patch changes 18 sec	0.9	1.3	5.9	2.4	-1.2	1.2	0.7	0.4	-1.0	-1.0	-0.8	-0.0
Patch foraging total patch changes 24 sec	0.6	1.1	2.5	1.6	-0.4	0.9	0.3	-0.1	-1.5	-1.6	-1.2	-0.6
Patch foraging total patch changes 6 sec	0.3	0.5	1.2	0.8	-0.6	1.1	0.9	0.6	-0.5	-0.5	-0.0	0.5
Patch foraging time to switch 0 sec	1.5	3.1	7.3	-2.7	2.2	-2.4	-1.9	-1.2	1.5	1.4	0.7	-0.7
Patch foraging water rate 0 sec	1.0	2.1	4.4	2.1	-1.9	1.9	1.5	1.2	-1.2	-0.9	-0.5	0.8
Patch foraging water rate 12 sec	1.7	3.6	7.7	1.7	-1.6	2.7	2.8	2.2	0.4	0.0	1.2	2.3
Patch foraging water rate 18 sec	1.5	2.3	5.6	1.6	-1.7	2.4	2.1	1.6	-0.9	-0.9	-0.0	1.1
Patch foraging water rate 24 sec	0.9	1.3	3.1	0.6	-1.0	1.3	1.6	1.0	0.7	0.6	1.1	1.7
Patch foraging water rate 6 sec	1.1	1.6	3.0	1.4	-1.3	1.7	1.6	1.0	0.4	0.1	0.8	1.7
Seeking ratio, delayed vs. immediate footshock	1.2	1.5	3.4	-1.5	0.7	-1.1	-0.6	-0.7	1.8	1.8	1.4	-0.7
Distance traveled before self-admin	0.3	0.4	1.1	-1.0	1.0	0.1	0.5	0.4	0.6	0.1	0.7	0.1
Distance traveled after self-admin	1.2	1.5	3.1	-1.0	-0.1	0.7	1.3	1.5	1.4	1.1	1.8	1.3
Extensor digitorum longus weight	0.1	0.2	0.8	-0.1	0.9	-0.1	-0.2	-0.6	-0.0	-0.6	-0.3	-0.6
Bone: elastic displacement	1.5	1.7	3.9	-1.8	0.7	-0.8	-0.1	-0.0	2.0	1.9	1.8	-0.2
Bone: elastic work	2.3	3.0	7.6	-2.2	0.7	-0.7	0.3	0.3	2.8	2.7	2.6	-0.2
Bone: endosteal estimation	1.0	2.2	5.2	1.9	-1.0	0.5	-0.1	-0.3	-2.3	-1.8	-2.1	-1.4
Bone: endosteal perimeter	1.1	2.4	5.8	2.4	-1.5	1.0	0.3	0.2	-2.2	-1.9	-2.0	-0.7
Epididymis fat weight	0.2	0.6	2.2	-1.1	1.5	-0.5	-0.5	-1.1	0.6	0.4	0.4	0.1
Delta time in closed arm before/after self-admin	1.6	1.5	4.1	-0.5	2.0	-1.1	-1.5	-1.6	-0.1	-0.5	-0.6	-1.5
Delta time in open arm before/after self-admin	1.6	1.5	3.5	1.7	-1.9	1.0	0.7	0.9	-1.6	-1.0	-1.3	-0.4
Diff in mean of infusions in LGA sessions	2.6	3.1	8.0	-1.8	1.6	-2.8	-2.5	-2.0	0.1	0.1	-0.8	-1.8
Delay discount exponential model param	0.3	0.3	1.1	0.1	-0.6	0.9	1.0	0.6	-0.1	0.1	0.5	0.5
Extinction: sum of active levers before priming	0.1	0.2	0.5	0.3	-0.2	0.0	-0.3	-0.1	-0.4	-0.5	-0.5	0.7
Active lever presses in extinction session 6	2.1	2.1	6.5	0.5	-1.4	1.3	1.5	1.7	0.8	0.9	1.3	2.6
Bone: final force	0.8	1.3	3.0	-0.4	1.1	-1.4	-1.7	-1.7	-0.7	-0.7	-1.2	-0.5
Bone: final moment	0.6	1.0	2.2	-0.3	0.8	-1.1	-1.5	-1.4	-0.7	-0.8	-1.2	-0.4
Food consumed during 24 hour testing period	2.0	2.7	7.9	2.1	-2.8	1.9	1.9	1.8	-0.3	0.1	0.3	1.1
Glucose	0.2	0.4	1.4	0.1	-0.6	0.5	0.7	0.3	0.6	1.2	0.7	-0.0
Heart weight	0.3	0.5	1.4	1.2	-1.1	0.6	0.5	0.5	-0.9	-0.1	-0.6	0.3
Delay discount hyperbolic model param	0.3	0.3	1.1	-0.2	-0.5	0.8	1.0	0.6	0.1	0.3	0.6	0.5
Intermittent access intake day 1-15 change	1.3	2.7	5.3	0.7	-1.5	1.8	2.2	2.3	1.3	0.8	1.5	1.8
Intermittent access intake escalation	1.3	2.7	5.6	0.8	-1.9	1.8	2.3	2.4	1.1	0.9	1.5	1.5
Intermittent access intake escalation 2	0.6	0.7	1.3	0.8	-0.9	1.0	1.0	1.1	0.5	0.4	0.6	0.9
Intermitt. access day 1 inactive lever presses	0.4	1.6	3.7	-1.1	1.7	-1.9	-1.9	-1.7	0.5	-0.0	-0.5	-0.1
Intermitt. access day 15 inactive lever presses	0.1	0.3	0.5	-0.6	0.5	-0.7	-0.4	0.2	0.6	0.7	0.4	0.3
Intermitt. access escalation Index	0.0	0.1	0.3	0.3	-0.2	-0.1	-0.0	-0.1	-0.1	-0.0	-0.2	-0.6
Intermittent access day 1 total infusions	0.5	0.8	2.9	1.7	-1.4	0.7	0.3	0.2	-0.9	-0.3	-0.7	0.5
Intermittent access day 15 total infusions	0.9	1.3	3.2	1.6	-1.8	1.2	1.2	1.3	-0.1	0.2	0.1	1.2
Intermittent access terminal intake (last 3 days)	1.0	1.4	3.6	1.9	-1.7	1.2	1.1	1.2	-0.5	-0.2	-0.3	1.1
Intermittent access total infusions	1.1	1.3	4.0	2.0	-1.6	1.3	1.0	1.0	-0.7	-0.4	-0.5	0.9
Intermittent access day 1 locomotion	0.2	0.3	0.6	0.6	-0.8	-0.4	-0.5	-0.6	-0.2	0.3	-0.4	-0.4
Intermittent access day 15 total locomotion	0.7	1.2	2.7	0.8	-1.6	0.8	0.9	1.1	1.0	1.2	1.0	1.4
Intermittent access total locomotion	0.4	0.5	1.9	1.1	-1.4	0.6	0.5	0.5	-0.2	0.2	-0.1	0.6
Intermittent access standard deviation	0.4	0.7	3.0	0.3	-0.1	0.9	1.0	1.1	0.3	-0.7	0.2	1.7
Left kidney weight	0.2	0.8	2.9	0.9	0.2	1.2	0.7	-0.1	-0.9	-1.7	-0.7	0.5
Right kidney weight	0.3	1.3	4.6	1.0	0.5	1.0	0.2	-0.6	-1.7	-2.1	-1.4	-0.1
Cocaine induced anxiety	1.8	2.6	5.7	-2.0	2.0	-2.4	-2.3	-1.6	0.9	0.9	0.0	-0.6
Post-drug Anxiety	2.2	2.4	5.1	-1.8	1.6	-2.2	-2.3	-1.6	-0.3	0.1	-0.8	-1.4
Baseline Anxiety	0.8	1.0	3.0	0.9	-1.0	0.6	0.3	-0.1	-1.7	-1.2	-1.2	-0.7
Tail length	1.6	6.3	16.8	2.0	-1.1	0.7	-0.4	-0.9	-4.1	-3.5	-3.6	-2.8
Length with tail	1.3	5.8	15.0	1.9	-0.7	0.6	-0.4	-1.3	-3.9	-3.6	-3.6	-2.1
Length without tail	0.1	0.4	0.9	0.1	0.1	-0.2	-0.3	-0.9	-0.8	-0.8	-1.0	-0.8
Times rat made contact with spout	0.4	0.4	1.0	-0.3	0.3	-0.6	-0.8	-0.9	-0.2	-0.5	-0.7	-1.0
Lifetime Intake	1.4	1.7	4.4	2.1	-1.8	1.5	1.2	1.2	-0.7	-0.4	-0.4	1.0
Liver weight, left	0.7	1.2	3.0	-0.0	1.1	-0.9	-1.1	-1.7	-0.7	-1.0	-1.2	-1.3
Liver weight, right	1.5	2.7	4.5	-0.6	2.0	-1.0	-1.4	-2.1	-1.3	-2.1	-1.6	-1.9
Locomotor activity	0.4	0.6	1.4	0.7	-0.6	1.2	0.8	0.6	-0.4	-0.6	-0.0	1.2
Locomotor testing distance	0.9	1.7	3.3	1.8	-1.3	1.8	1.0	0.5	-1.3	-1.6	-0.8	0.9
Locomotor testing rearing	0.6	1.3	3.8	1.4	-0.5	0.9	0.1	-0.3	-1.6	-2.0	-1.4	-0.1
Locomotion in novel chamber	0.9	1.1	3.6	0.1	0.2	0.2	0.3	0.0	1.7	1.2	1.4	1.9
Locomotion in novel chamber post-restriction	0.8	1.4	4.3	1.5	-2.1	1.2	1.2	1.1	0.3	0.6	0.5	1.1
Fecal boli incidents, locomotor time 1	0.9	1.4	5.4	0.2	0.3	-1.3	-1.3	-0.4	1.2	1.3	0.3	2.3
Change in fecal boli incidents, locomotor task	1.0	1.0	7.6	-0.8	0.5	0.2	0.3	-0.3	-0.6	-0.2	0.0	-2.8
Time >=10cm from walls, locomotor time 1	0.2	0.3	1.1	1.0	-0.6	0.4	0.2	0.2	-0.7	-0.1	-0.4	-0.0
Bouts of movement, locomotor time 1	0.4	0.4	0.9	0.4	-0.1	-0.7	-0.9	-0.8	-0.7	-0.3	-1.0	-0.4
Total resting periods, locomotor time 1	0.1	0.2	0.6	-0.0	0.0	-0.7	-0.8	-0.4	-0.0	0.2	-0.3	-0.1
Rest time, locomotor task time 1	0.2	0.3	1.1	-0.3	0.0	-0.7	-0.4	-0.2	-0.0	0.9	0.1	-1.1
Distance moved, locomotor task time 1	0.1	0.1	0.5	0.4	-0.0	0.5	0.3	0.1	-0.1	-0.7	-0.2	0.4
Vertical activity count, locomotor time 1	0.2	0.4	1.6	0.8	-0.0	0.1	-0.3	-0.2	-0.4	-1.3	-0.8	0.9
Time >=10cm from walls, locomotor time 2	1.3	1.9	5.6	1.7	-0.6	0.7	0.0	0.3	-2.4	-1.7	-1.9	-1.1
Bouts of movement, locomotor time 2	1.7	2.7	5.7	0.6	1.0	-0.8	-1.6	-1.5	-2.1	-2.1	-2.4	-1.6
Total resting periods, locomotor time 2	1.3	2.2	4.0	0.3	1.1	-1.1	-1.7	-1.6	-1.6	-1.7	-2.0	-1.6
Rest time, locomotor task time 2	1.1	1.4	3.3	-1.8	1.5	-1.4	-0.9	-0.8	1.2	1.1	0.8	-0.8
Distance moved, locomotor task time 2	1.7	2.1	5.0	2.2	-1.6	1.6	1.0	1.3	-1.4	-1.4	-1.1	0.7
Vertical activity count, locomotor time 2	0.7	1.0	2.6	1.2	-0.2	0.1	-0.5	0.2	-1.3	-1.6	-1.5	0.8
Light reinforcement 1	0.8	1.9	4.6	-2.1	1.9	-0.8	-0.4	-0.6	1.8	1.2	1.6	-0.9
Light reinforcement 2	1.7	2.6	6.1	-1.2	-0.6	1.2	1.8	1.6	2.0	1.7	2.5	1.1
Bone: marrow area	0.9	2.0	4.6	1.8	-0.8	0.3	-0.2	-0.4	-2.2	-1.7	-2.0	-1.4
Bone: maximum diameter	1.2	2.3	6.2	2.5	-1.4	1.2	0.6	0.5	-2.1	-1.8	-1.7	-0.4
Bone: maximum force	0.3	0.5	1.2	-0.2	0.5	-0.9	-1.1	-1.1	-0.4	-0.3	-0.7	-0.6
Bone: maximum moment	0.1	0.3	0.6	0.0	0.2	-0.5	-0.7	-0.8	-0.4	-0.3	-0.6	-0.5
Mean time between licks in bursts	2.3	5.5	13.8	3.0	-0.8	1.1	-0.2	-0.1	-3.7	-3.7	-3.4	-0.1
Mean num. licks in bursts	1.5	2.4	5.8	2.3	-2.4	1.8	1.5	1.4	-1.1	-0.6	-0.5	1.0
Cd content in liver	0.6	0.6	1.2	-0.2	0.4	-0.9	-1.1	-1.0	-0.6	-0.5	-0.9	-1.0
Co content in liver	1.4	1.7	4.2	1.7	-0.6	0.4	-0.5	-0.3	-2.1	-1.8	-1.9	-0.4
Cu content in liver	1.0	1.2	2.7	1.3	-0.2	0.0	-0.6	-0.6	-1.6	-1.5	-1.7	-1.0
Fe content in liver	0.0	0.0	0.1	-0.1	0.0	-0.3	-0.3	-0.3	0.0	0.0	-0.1	-0.3
K content in liver	0.4	0.4	1.0	-0.2	0.7	-0.3	-0.5	-0.7	-0.1	-0.9	-0.6	1.0
Mg content in liver	0.3	0.3	1.6	0.3	-0.4	0.7	0.6	0.5	0.3	-0.2	0.3	1.3
Mn content in liver	1.3	1.4	3.5	-1.6	0.6	-0.5	0.1	0.1	1.9	1.7	1.7	0.4
Na content in liver	0.9	1.0	3.0	0.9	-1.7	1.2	1.3	1.2	0.0	0.1	0.3	0.5
Rb content in liver	0.2	0.3	0.9	0.7	-0.9	-0.2	-0.4	-0.4	-0.4	-0.2	-0.7	-0.3
Se content in liver	3.0	3.6	8.4	-2.9	1.9	-2.2	-1.5	-1.5	2.1	2.0	1.3	-1.0
Sr content in liver	1.7	1.4	3.1	0.1	-0.9	1.3	1.7	1.8	0.9	1.1	1.5	0.4
Zn content in liver	1.8	2.1	4.5	2.1	-1.4	1.9	1.5	1.4	-1.0	-1.2	-0.5	1.2
Bone: minimum diameter	1.3	2.3	6.2	1.6	-0.1	0.2	-0.6	-0.9	-2.2	-2.5	-2.3	-0.8
Time in familiar zone, hab. session 1	0.1	0.1	0.2	0.1	-0.1	0.5	0.4	0.3	-0.5	-0.5	-0.2	-0.4
Time in novel zone, hab. session 1	0.4	0.4	0.8	-0.4	0.8	-0.9	-0.9	-0.9	-0.0	0.3	-0.2	-0.9
Total zone transitions, hab. session 1	0.5	0.7	1.7	0.2	-1.3	0.6	1.1	1.0	0.5	0.8	0.9	0.3
Total locomotion distance, hab. session 1	1.0	1.4	2.5	-0.4	1.5	-0.6	-1.0	-1.2	-1.2	-1.6	-1.4	-1.0
Locomotion velocity, hab. session 1	0.7	0.9	2.5	-0.3	1.3	-0.4	-0.8	-1.0	-1.0	-1.6	-1.2	-0.2
Time in familiar zone, hab. session 2	1.1	1.2	3.8	1.3	-0.6	0.9	0.4	0.4	-2.0	-1.4	-1.3	-0.3
Time in novel zone, hab. session 2	1.1	1.1	3.7	-0.7	0.1	0.1	0.5	0.4	1.9	1.2	1.6	1.1
Total zone transitions, hab. session 2	1.9	2.5	5.7	1.4	-2.4	2.0	2.1	2.1	-0.3	-0.1	0.5	1.3
Total locomotion distance, hab. session 2	1.3	1.7	6.9	0.8	0.6	0.6	-0.1	-0.4	-1.9	-2.6	-1.8	0.4
Locomotion velocity, hab. session 2	1.4	1.9	7.5	0.7	0.7	0.5	-0.2	-0.5	-2.0	-2.7	-1.9	0.3
Novel to familiar place preference ratio	1.3	1.4	3.3	0.4	0.4	-0.9	-1.4	-1.4	-1.4	-1.5	-1.8	-0.1
Novelty place preference	1.2	1.3	3.1	0.5	0.3	-0.7	-1.3	-1.2	-1.5	-1.6	-1.8	-0.0
Time in novel zone, NPP test	1.3	1.4	3.5	0.6	0.3	-0.6	-1.2	-1.1	-1.6	-1.7	-1.9	0.1
Total zone transitions, NPP test	1.3	1.8	4.3	0.6	-1.4	1.3	1.6	1.5	1.2	0.8	1.4	2.1
Total locomotion distance, NPP test	0.4	0.6	1.7	-0.2	1.2	0.5	0.2	-0.1	-0.1	-1.3	-0.2	1.3
Locomotion velocity, NPP test	0.4	0.5	1.9	-0.5	1.4	0.3	0.1	-0.2	0.2	-1.0	-0.0	1.1
Intraocular pressure	0.9	1.3	5.6	-0.2	-0.9	-0.1	0.6	0.7	1.4	2.4	1.7	-0.0
Delta distance traveled before/after self-admin	0.7	0.8	3.1	1.1	-1.8	0.7	0.7	0.8	-0.5	0.0	-0.0	1.0
Delta ambulatory time before/after self-admin	0.6	0.8	3.0	0.9	-1.7	0.7	0.7	0.9	-0.2	0.3	0.2	1.0
Parametrial fat weight	0.7	1.6	4.5	-1.3	0.5	0.5	1.3	0.7	1.9	1.2	2.1	-0.8
Pavlov. Cond. lever latency	0.7	0.9	3.8	-1.9	1.3	-0.5	-0.2	-0.2	0.9	0.8	1.0	-0.5
Pavlov. Cond. magazine entry latency	2.2	2.8	7.1	2.7	-2.1	2.0	1.7	1.5	-1.4	-1.2	-0.8	0.8
Pavlov. Cond. change in total contacts	0.9	0.9	2.8	1.7	-1.2	0.3	-0.1	-0.0	-1.3	-0.8	-1.3	-0.3
Pavlov. Cond. index score	1.6	2.0	6.5	2.5	-2.0	1.4	1.0	1.0	-1.3	-1.0	-1.0	0.6
Pavlov. Cond. latency score	1.5	1.9	6.5	2.6	-1.9	1.2	0.8	0.8	-1.3	-1.0	-1.1	0.7
Pavlov. Cond. lever contacts	0.7	0.8	3.2	1.8	-1.3	0.7	0.5	0.5	-0.8	-0.6	-0.7	0.1
Pavlov. Cond. magazine entry number	1.9	2.5	7.4	-2.7	2.2	-1.6	-1.2	-1.1	1.4	1.1	1.0	-0.5
Pavlov. Cond. intertrial magazine entries	0.6	0.7	1.7	-1.3	0.8	-1.2	-1.2	-1.0	0.5	0.3	0.0	-0.3
Pavlov. Cond. lever-magazine prob. diff.	1.3	1.6	5.1	2.3	-1.9	1.2	0.9	0.9	-1.1	-0.8	-0.8	0.4
Pavlov. Cond. response bias	1.0	1.3	3.6	1.9	-1.6	1.3	1.1	1.0	-0.9	-0.7	-0.5	0.5
Pavlov. Cond. lever latency	12.4	16.8	35.5	-6.0	5.2	-5.2	-4.1	-4.2	3.1	2.8	1.4	-2.9
Pavlov. Cond. magazine entry latency	5.1	6.2	11.9	2.2	-2.7	3.5	3.3	3.3	-0.1	-0.5	0.9	3.1
Pavlov. Cond. change in total contacts	9.1	14.6	26.4	5.1	-5.1	4.9	4.0	4.1	-2.7	-2.5	-1.1	2.7
Pavlov. Cond. index score	9.9	13.3	23.0	4.8	-4.5	4.8	3.9	4.0	-2.3	-2.3	-0.9	3.3
Pavlov. Cond. latency score	9.1	12.1	21.5	4.5	-4.3	4.6	3.8	4.0	-1.9	-2.0	-0.5	3.2
Pavlov. Cond. lever contacts	11.4	15.7	33.8	5.8	-5.1	4.9	3.7	3.9	-3.1	-2.9	-1.6	2.9
Pavlov. Cond. magazine entry number	6.8	8.4	15.5	-3.0	3.6	-3.9	-3.6	-3.7	0.8	0.9	-0.4	-3.1
Pavlov. Cond. intertrial magazine entries	1.1	1.7	3.6	0.7	0.2	-0.7	-1.2	-1.3	-1.7	-1.5	-1.9	-1.5
Pavlov. Cond. lever-magazine prob. diff.	9.3	12.4	21.7	4.6	-4.3	4.7	3.7	3.9	-2.3	-2.3	-0.9	3.1
Pavlov. Cond. response bias	12.5	17.0	31.7	5.6	-5.3	5.3	4.3	4.4	-2.7	-2.6	-1.1	3.4
Time in closed arm before self-admin	1.5	1.9	3.6	1.0	-1.9	1.8	1.9	1.9	-0.5	-0.3	0.3	1.5
Time in closed arm after self-admin	0.4	0.5	1.0	-0.9	1.0	-0.9	-0.7	-0.8	0.5	0.4	0.4	0.1
Time in open arm before self-admin	2.7	3.0	5.6	-2.1	2.4	-1.8	-1.2	-1.2	2.2	1.8	1.5	-0.6
Time in open arm after self-admin	0.2	0.2	1.6	0.4	-0.1	0.0	-0.1	0.1	-0.4	-0.2	-0.4	-1.3
Bone: periosteal estimation	0.7	1.5	3.5	1.9	-0.8	0.6	0.1	-0.2	-1.7	-1.6	-1.6	-0.7
Bone: periosteal perimeter	0.8	1.5	4.0	2.0	-1.1	1.1	0.7	0.5	-1.4	-1.5	-1.2	-0.1
Bone: post-yield work	0.1	0.1	0.3	0.3	-0.0	0.3	0.1	0.1	-0.6	-0.4	-0.3	-0.4
Progressive ratio test 1 active lever presses	0.1	0.1	0.4	0.1	-0.6	-0.1	0.0	0.2	0.2	0.7	0.3	-0.2
Progressive ratio test 1 breakpoint	0.1	0.1	0.5	0.1	-0.6	-0.1	-0.0	0.2	0.2	0.7	0.2	-0.4
Progressive ratio test 1 inactive lever presses	0.1	0.2	0.5	-0.1	0.0	-0.6	-0.6	-0.6	0.5	0.7	0.1	0.1
Progressive ratio test 2 active lever presses	0.2	0.3	1.1	1.0	-1.1	0.3	0.1	0.1	-0.3	-0.0	-0.4	0.2
Progressive ratio test 2 breakpoint	0.3	0.3	1.3	1.0	-1.1	0.4	0.1	0.1	-0.3	0.0	-0.4	0.2
Progressive ratio test 2 inactive lever presses	0.3	0.5	2.2	0.6	-0.8	0.4	0.3	0.6	0.3	0.4	0.2	1.5
Incentive Sensitization - Responses	0.3	0.4	1.2	1.1	-0.9	0.6	0.1	0.0	-0.6	-0.5	-0.7	0.6
Incentive Sensitization - Breakpoint	0.3	0.4	1.0	1.0	-1.0	0.7	0.3	0.2	-0.4	-0.4	-0.4	0.8
Sum of active levers in priming session hrs 5-6	0.3	0.3	0.8	0.2	-0.4	0.6	0.6	0.9	-0.0	-0.1	0.1	0.9
Progressive ratio	1.0	1.5	2.6	0.5	-1.5	1.3	1.6	1.6	0.9	0.9	1.2	1.0
Food seeking constrained by brief footshock	1.2	1.5	3.1	1.6	-0.9	1.4	1.0	1.1	-1.5	-1.7	-1.0	-0.2
Seeking ratio, punishment vs. effort	1.0	1.5	5.2	0.9	0.3	0.3	-0.3	-0.4	-1.9	-2.3	-1.8	-0.4
Retroperitoneal fat weight	0.8	3.4	9.2	-1.9	3.0	-1.0	-1.1	-2.5	0.2	-1.5	-0.5	-2.6
Reaction time number correct	0.2	0.4	1.4	-0.3	-0.3	0.3	0.6	0.5	0.6	0.5	0.7	1.2
Reaction time mean minus median	0.3	0.7	1.7	1.3	-0.3	0.5	0.1	-0.1	-1.0	-1.2	-1.0	0.7
Reaction time mean minus median AUC	0.3	0.7	1.6	1.3	-0.6	0.6	0.2	0.1	-0.8	-0.9	-0.8	1.2
Reaction time num false alarms	2.2	3.1	6.9	-1.5	2.5	-2.0	-2.4	-2.6	0.1	-0.4	-0.7	-1.4
Reaction time num false alarms AUC	1.4	2.2	5.4	-1.2	2.1	-1.8	-2.2	-2.3	0.3	-0.1	-0.5	-0.6
Reaction time trials correct on left	0.2	0.4	1.4	-0.3	-0.3	0.3	0.6	0.5	0.6	0.5	0.7	1.2
Reaction time trials on left	0.2	0.4	1.5	-0.3	-0.2	0.3	0.7	0.5	0.6	0.5	0.7	1.2
Reaction time mean	1.2	1.9	4.2	-0.7	1.9	-1.8	-2.1	-1.7	-0.4	-1.0	-1.3	-0.1
Reaction time mean AUC	1.2	1.9	4.5	-1.0	1.8	-2.0	-2.1	-1.7	-0.2	-0.7	-1.1	-0.1
Median of all reaction times	1.7	2.4	5.4	-1.3	2.3	-2.2	-2.3	-1.9	-0.1	-0.6	-1.1	-0.2
Reaction time omissions	0.2	0.3	0.8	0.0	0.7	-0.3	-0.4	-0.9	0.1	-0.7	-0.4	0.4
Reaction time false alarm rate	1.6	2.2	5.1	-1.1	2.2	-1.7	-2.1	-2.3	0.2	-0.3	-0.6	-1.0
Reaction time premature initiation rate	1.3	1.8	3.7	1.8	-0.6	1.1	0.5	0.6	-1.9	-1.9	-1.6	-0.9
Reaction time premature initiations	0.5	1.0	2.0	1.4	-0.7	1.1	0.8	0.8	-1.2	-1.3	-0.9	0.1
Std. dev. reaction times	0.9	1.6	4.0	0.9	0.7	-0.7	-1.4	-1.3	-1.5	-1.8	-2.0	-0.3
Reaction time trials completed	0.2	0.4	1.5	-0.3	-0.2	0.3	0.7	0.5	0.6	0.5	0.7	1.2
Reaction time trials AUC	0.1	0.2	1.1	-0.2	-0.1	0.3	0.6	0.3	0.4	0.3	0.5	1.1
Run reversals in cocaine runway, females	0.9	0.9	3.3	0.4	0.4	0.5	0.1	-0.5	-1.2	-1.8	-1.1	-1.3
Run reversals in cocaine runway, males	0.3	0.3	0.8	-0.4	0.0	-0.8	-0.6	-0.4	0.7	0.9	0.3	-0.1
Latency to leave start box in cocaine runway	1.5	1.7	4.7	-1.6	1.7	-1.6	-1.4	-0.7	0.3	0.3	-0.1	-2.2
Latency to leave start box in cocaine runway, F	1.9	2.2	5.5	-1.2	1.8	-1.8	-1.9	-1.2	-0.5	-0.4	-1.0	-2.3
Latency to leave start box in cocaine runway, M	0.6	0.6	1.6	-0.8	0.3	-0.1	0.2	0.5	1.2	1.1	1.2	-0.1
Std. dev. time between licks in bursts	1.9	2.5	7.3	1.6	0.3	0.2	-0.7	-0.7	-2.4	-2.7	-2.5	-0.1
Total sessions with >9 infusions	1.4	1.8	4.3	2.1	-2.0	1.6	1.3	1.1	-1.0	-0.6	-0.5	0.8
Short access day 1 total inactive lever presses	0.2	0.3	0.8	0.2	-0.1	-0.7	-0.9	-0.3	-0.4	-0.3	-0.9	0.4
Short access day 10 total inactive lever presses	0.4	1.0	2.4	-0.9	1.4	-1.6	-1.5	-1.1	0.7	0.4	-0.1	-0.1
Short access day 1 total infusions	1.9	2.5	6.6	2.6	-1.8	1.4	0.8	0.8	-1.8	-1.6	-1.5	1.3
Short access day 10 total infusions	1.3	1.6	4.5	2.1	-2.0	1.5	1.2	1.0	-0.8	-0.5	-0.5	0.7
Short access total infusions	1.4	1.8	4.8	2.2	-2.0	1.5	1.3	1.2	-1.0	-0.6	-0.6	0.7
Short access day 1 locomotion	1.1	1.4	4.2	1.4	-2.1	1.0	1.0	0.8	0.3	0.8	0.5	1.7
Short access day 10 total locomotion	0.8	1.4	3.0	1.6	-1.6	1.3	1.1	1.1	-0.1	-0.6	-0.1	1.7
Short access total locomotion	0.6	0.7	2.0	0.8	-1.4	0.6	0.7	0.7	0.5	0.7	0.6	0.9
One hour access (0.3 mA shock)	0.8	1.0	2.6	1.6	-1.2	1.2	1.0	1.0	0.0	0.1	0.2	1.1
Compulsive drug intake	1.4	1.6	4.1	-1.5	0.5	-0.7	-0.1	-0.1	1.9	2.0	1.8	0.7
One hour access (shock baseline)	1.4	2.2	4.8	2.2	-1.7	1.9	1.5	1.6	-0.7	-0.9	-0.4	1.5
Social response proportion	0.5	0.5	2.1	-0.6	1.5	-0.3	-0.5	-1.0	0.2	-0.7	-0.2	0.7
Social responses	1.4	1.8	5.1	-0.0	1.6	-0.6	-1.2	-2.2	-0.9	-1.9	-1.4	0.1
Social time	1.1	1.5	5.2	-2.3	1.6	-1.3	-1.0	-0.9	1.2	0.7	0.7	0.0
Soleus weight	0.6	1.7	3.2	0.0	1.7	-0.8	-1.3	-1.7	-1.0	-1.8	-1.6	-0.9
Bone: stiffness	1.5	2.5	5.1	-0.6	1.6	-1.9	-2.2	-2.3	-0.9	-1.1	-1.7	-1.1
Tibialis anterior weight	0.2	0.8	2.0	0.5	0.5	-0.1	-0.6	-0.8	-1.1	-1.4	-1.3	-0.5
Time to tail flick, vehicle, before self-admin	0.8	0.8	2.2	0.4	-1.2	1.2	1.5	1.3	0.0	0.0	0.3	-0.2
Time to tail flick, vehicle, after self-admin	0.4	0.5	1.7	1.1	-1.3	0.3	0.2	0.8	-0.8	-0.1	-0.6	0.0
Time to tail flick, test, before self-admin	1.4	1.5	4.5	1.1	-1.1	0.7	0.2	0.1	-1.8	-0.9	-1.3	-2.1
Time to tail flick, test, after self-admin	1.6	1.6	4.2	1.0	0.1	-0.1	-0.6	-0.3	-2.0	-1.7	-2.0	-1.5
Delta time to tail flick, vehicle, before/after SA	0.2	0.2	0.6	0.5	-0.2	-0.6	-0.8	-0.3	-0.2	0.2	-0.4	0.4
Delta time to tail flick, test, before/after SA	0.3	0.3	1.6	-0.6	1.3	-0.6	-0.3	-0.3	0.6	-0.0	0.3	0.3
Tibia length	0.6	1.7	5.2	1.7	-2.1	0.9	0.7	0.7	-0.6	-0.4	-0.5	2.3
Ambulatory time before self-admin	0.3	0.4	1.5	-1.2	1.0	-0.1	0.2	0.1	0.7	0.4	0.8	0.1
Ambulatory time after self-admin	1.0	1.2	2.2	-0.6	-0.7	0.8	1.3	1.5	0.8	0.9	1.4	1.3
Bone: tissue strength	1.8	1.8	4.5	-1.3	-0.2	0.3	0.9	0.9	2.0	1.9	2.1	0.9
Total heroin consumption	0.5	0.6	2.6	0.4	-0.4	0.9	0.8	0.5	-0.1	-0.6	0.1	1.6
Bone: trabecular number	0.8	1.3	3.1	-1.4	0.2	-0.8	-0.2	-0.1	1.6	1.8	1.4	-0.8
Bone: trabecular spacing	1.3	1.7	4.6	0.9	-1.2	1.6	1.7	1.5	0.4	-0.0	0.7	2.2
Bone: trabecular thickness	1.4	1.7	3.1	-0.5	1.0	-1.4	-1.8	-1.7	-1.1	-0.8	-1.4	-1.6
Bone: trabecular tissue density	3.5	5.2	9.9	-0.9	2.6	-2.4	-3.0	-3.1	-1.5	-2.0	-2.5	-1.3
Water consumed over 24 hours	0.2	0.2	0.5	-0.7	0.2	-0.6	-0.3	-0.5	0.6	0.6	0.4	-0.5
Number of responses in last shaping day	1.7	1.9	4.2	-0.2	1.3	-1.6	-2.0	-2.0	-0.7	-0.7	-1.4	-1.3