Hub : Genes

Pde2a

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 NAcc gene expression Pde2a 0.05 0.03 7.9e-07 0.04 0.04 0.03 0.04 2.5e-07 1.5e-06 6.8e-06 3.2e-06
2 Liver gene expression Pde2a 0.06 0.04 2.4e-06 0.01 0.03 0.03 0.02 1.3e-02 2.8e-04 2.5e-04 1.4e-03
3 BLA alternative TSS NM_001143847.2 0.06 0.04 9.6e-03 0.04 0.01 0.01 0.03 3.8e-03 9.8e-02 5.7e-02 6.7e-03
4 BLA mRNA stability Pde2a 0.16 0.12 3.9e-04 0.03 0.05 0.02 0.04 7.6e-03 1.6e-03 2.3e-02 4.0e-03
5 NAcc mRNA stability Pde2a 0.02 0.02 4.2e-04 0.03 0.02 0.02 0.03 3.5e-05 1.6e-04 3.8e-04 6.3e-05
6 Brain mRNA stability Pde2a 0.09 0.05 3.0e-10 0.12 0.11 0.1 0.12 1.8e-11 1.5e-10 4.9e-10 4.3e-11
7 IC gene expression Pde2a 0.19 0.11 1.0e-04 0.06 0.1 0.08 0.07 1.1e-03 7.5e-05 2.6e-04 5.5e-04
8 Brain isoform ratio NM_001143847.2 0.04 0.03 8.8e-03 0.03 0.01 0.02 0.02 1.2e-03 4.2e-02 7.8e-03 8.8e-03
9 Brain gene expression Pde2a 0.1 0.06 3.4e-07 0.05 0.06 0.06 0.06 1.5e-05 1.6e-06 2.8e-06 2.0e-06
10 IL mRNA stability Pde2a 0.28 0.16 2.3e-04 0.08 0.09 0.11 0.06 5.0e-03 3.8e-03 1.7e-03 1.6e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10
Bone: apparent density0.20.41.10.60.0-0.6-0.60.30.30.7-1.00.60.8
Area under the delay curve0.30.41.40.0-0.60.1-1.01.20.7-0.00.2-0.60.6
BMI with tail0.51.75.4-0.2-0.90.42.0-1.6-0.20.81.31.0-2.3
BMI without tail0.42.17.8-1.10.51.42.8-2.1-0.6-0.71.80.1-0.9
Body weight0.52.08.2-1.0-0.51.41.6-0.60.9-1.72.9-1.5-0.4
Weight adjusted by age0.10.30.6-0.30.20.60.6-0.3-0.6-0.80.4-0.40.6
Bone surface0.30.71.7-1.31.21.00.20.00.0-0.90.3-0.81.1
Bone volume0.20.30.6-0.80.60.7-0.00.20.3-0.70.4-0.70.7
Breakpoint value in progressive ratio session0.40.62.20.9-0.6-1.5-0.50.20.10.9-0.40.7-1.1
Number of licking bursts0.92.86.32.5-2.5-1.6-2.01.71.81.0-0.40.31.4
Context. condit. distance diff. score2.02.44.6-1.62.01.42.1-2.1-2.1-0.80.30.2-1.0
Locomotion velocity, session 11.11.23.00.90.1-0.90.2-0.8-0.81.7-1.51.7-1.1
Locomotion distance, session 11.31.73.4-0.81.60.41.5-1.8-1.80.6-0.51.0-1.8
Locomotion velocity, session 20.70.81.9-0.60.80.51.2-1.2-1.10.6-0.00.7-1.4
Locomotion distance, session 21.21.65.8-0.80.90.91.6-1.6-1.50.50.20.8-2.4
Locomotion velocity, session 30.40.51.5-0.71.2-0.40.7-0.9-1.0-0.3-0.10.1-0.5
Locomotion distance, session 30.70.82.7-0.61.60.20.9-1.2-1.30.1-0.90.7-0.2
Stereotopy head waving bouts, day 30.50.61.10.1-0.8-0.2-0.60.91.0-0.71.1-1.00.6
Stereotopy head waving duration, day 30.10.20.4-0.40.50.00.6-0.6-0.5-0.10.20.2-0.4
Locomotion velocity, session 70.40.51.10.8-0.1-0.00.3-0.7-0.80.9-0.81.1-0.5
Locomotion distance, session 70.20.20.80.5-0.90.6-0.50.40.40.10.1-0.1-0.0
Stereotopy head waving bouts, day 72.02.38.7-2.02.90.81.7-1.6-1.8-0.8-0.10.00.0
Stereotopy head waving duration, day 72.02.58.3-2.12.90.92.0-1.8-1.9-0.70.10.0-0.4
Locomotion velocity, session 80.81.02.4-1.51.50.71.2-1.0-1.1-0.90.5-0.3-0.5
Locomotion distance, session 82.53.77.1-1.82.21.62.7-2.6-2.5-0.60.80.3-2.4
Degree of sensitization distance1.41.63.90.0-1.71.0-0.61.21.4-1.12.0-1.60.1
Degree of sensitization stereotypy3.43.812.1-2.63.51.32.3-2.2-2.3-1.20.1-0.1-0.2
Conditioned locomotion0.70.91.40.5-1.0-1.1-1.01.21.1-0.60.9-1.0-0.9
Cocaine response after cond. corrected0.71.02.51.3-1.6-1.2-1.10.91.00.6-0.10.10.8
Cocaine response after cond. not corrected0.30.41.10.8-0.7-0.8-0.30.00.21.0-0.80.80.4
Cocaine response before conditioning1.72.14.4-1.12.10.41.7-2.0-2.00.6-1.31.4-0.5
Saline control response1.52.14.9-2.21.51.70.70.0-0.1-2.01.6-1.80.5
Bone: connectivity density0.81.24.00.30.8-0.50.2-0.8-0.91.5-2.01.70.4
Bone: cortical apparent density0.91.54.31.3-2.1-1.3-1.41.51.60.20.4-0.30.5
Bone: cortical area0.30.41.4-1.10.20.30.30.10.2-0.81.2-0.9-0.2
Bone: cortical porosity0.10.10.3-0.10.4-0.4-0.40.40.2-0.1-0.4-0.2-0.5
Bone: cortical porosity0.10.10.5-0.30.7-0.3-0.20.30.0-0.1-0.4-0.2-0.3
Bone: cortical thickness0.30.41.60.4-0.6-1.2-0.0-0.10.00.9-0.20.7-0.8
Bone: cortical thickness0.10.20.7-0.5-0.00.00.2-0.1-0.0-0.30.6-0.4-0.8
Bone: cortical tissue density0.91.54.31.3-2.1-1.3-1.41.51.60.30.3-0.20.5
Condit. Reinf. active minus inactive responses0.70.82.2-0.90.00.8-0.10.40.5-1.51.2-1.40.6
Condit. Reinf. active-inactive response ratio1.41.53.4-1.10.21.4-0.30.60.7-1.91.2-1.81.3
Condit. Reinf. active responses0.50.71.8-0.4-0.30.3-0.60.90.9-1.01.2-1.4-0.1
Condit. Reinf. inactive responses0.30.32.10.4-0.5-0.5-0.30.40.40.50.30.0-1.4
Incentive salience index mean0.50.71.9-1.00.11.0-0.20.50.6-1.11.2-1.4-0.1
Condit. Reinf. lever presses0.20.31.1-0.90.70.90.2-0.2-0.10.10.2-0.2-1.0
Condit. Reinf. active minus inactive responses4.36.614.3-3.73.03.82.5-1.6-1.6-2.92.4-2.0-0.3
Condit. Reinf. active-inactive response ratio0.71.12.6-1.31.61.61.2-0.9-1.0-0.70.4-0.3-0.0
Condit. Reinf. active responses6.99.922.1-4.53.24.72.8-1.6-1.6-3.73.3-2.9-0.7
Condit. Reinf. inactive responses3.95.812.1-3.51.93.41.7-0.7-0.7-3.03.1-2.7-1.1
Condit. Reinf. lever presses11.015.933.1-5.84.85.74.4-3.1-3.2-3.43.1-2.2-2.3
Condit. Reinf. lever reinforcers received7.710.924.2-4.83.64.93.0-1.8-1.8-3.73.3-2.8-1.0
Conditioned reinforcement - actives0.10.51.2-1.00.90.50.5-0.6-0.70.2-0.50.2-1.1
Conditioned reinforcement - inactives0.30.72.10.5-1.0-0.6-1.41.51.10.0-0.0-0.60.3
Conditioned locomotion1.42.15.1-1.21.90.81.3-1.5-1.70.8-1.11.1-2.3
Patch foraging indifference point 0 sec0.61.84.2-2.11.91.61.9-1.3-0.5-0.90.8-0.4-0.9
Patch foraging indifference point AUC0.20.51.3-1.10.10.60.4-0.20.0-0.91.1-0.80.8
Delay disc. indifference point, 0s delay0.91.12.4-1.51.01.40.9-0.5-0.4-0.91.4-0.8-0.7
Delay disc. indifference point, 16s delay0.71.02.80.6-1.0-0.3-1.41.71.3-0.40.3-0.91.1
Delay disc. indifference point, 2s delay0.80.82.0-1.20.81.40.10.3-0.2-1.11.2-1.3-0.2
Delay disc. indifference point, 24s delay1.01.63.41.4-1.8-1.5-1.81.91.20.20.1-0.50.6
Delay disc. indifference point, 4s delay1.31.43.3-1.50.61.40.50.20.1-1.61.8-1.7-0.0
Delay disc. indifference point, 8s delay0.10.20.6-0.1-0.50.1-0.70.80.40.2-0.3-0.20.2
Indifference point function ln k0.20.61.7-0.01.20.10.5-0.7-0.80.5-0.90.7-1.3
Indifference point function log k0.20.61.7-0.01.20.10.5-0.7-0.80.5-0.90.7-1.3
Patch foraging total patch changes 0 sec0.61.63.8-1.91.71.61.9-1.3-0.4-0.70.7-0.3-0.7
Patch foraging total patch changes 12 sec0.91.23.3-1.60.41.10.8-0.20.1-1.51.8-1.40.1
Patch foraging total patch changes 18 sec0.61.55.9-2.41.21.81.2-0.7-0.4-1.01.0-0.80.0
Patch foraging total patch changes 24 sec0.41.32.6-1.60.41.60.9-0.30.1-1.51.6-1.20.6
Patch foraging total patch changes 6 sec0.30.41.2-0.80.60.51.1-0.9-0.6-0.50.5-0.0-0.5
Patch foraging time to switch 0 sec0.93.37.32.7-2.2-2.4-2.41.91.21.5-1.40.70.7
Patch foraging water rate 0 sec0.62.24.4-2.11.91.91.9-1.5-1.2-1.20.9-0.5-0.8
Patch foraging water rate 12 sec0.83.37.7-1.71.61.12.7-2.8-2.20.4-0.01.2-2.3
Patch foraging water rate 18 sec1.12.45.6-1.61.71.92.4-2.1-1.6-0.90.9-0.0-1.1
Patch foraging water rate 24 sec0.81.23.1-0.61.00.01.3-1.6-1.00.7-0.61.1-1.7
Patch foraging water rate 6 sec1.01.53.0-1.41.31.21.7-1.6-1.00.4-0.10.8-1.7
Seeking ratio, delayed vs. immediate footshock1.11.63.41.5-0.7-1.6-1.10.60.71.8-1.81.40.7
Distance traveled before self-admin0.20.41.11.0-1.0-0.70.1-0.5-0.40.6-0.10.7-0.1
Distance traveled after self-admin0.81.53.11.00.1-1.20.7-1.3-1.51.4-1.11.8-1.3
Extensor digitorum longus weight0.10.20.80.1-0.90.4-0.10.20.6-0.00.6-0.30.6
Bone: elastic displacement1.51.94.01.8-0.7-2.0-0.80.10.02.0-1.91.80.2
Bone: elastic work2.53.37.62.2-0.7-2.5-0.7-0.3-0.32.8-2.72.60.2
Bone: endosteal estimation1.02.55.5-1.91.02.40.50.10.3-2.31.8-2.11.4
Bone: endosteal perimeter1.22.86.3-2.41.52.51.0-0.3-0.2-2.21.9-2.00.7
Epididymis fat weight0.10.72.21.1-1.5-0.9-0.50.51.10.6-0.40.4-0.1
Delta time in closed arm before/after self-admin1.41.34.10.5-2.0-0.4-1.11.51.6-0.10.5-0.61.5
Delta time in open arm before/after self-admin1.41.73.5-1.71.91.81.0-0.7-0.9-1.61.0-1.30.4
Diff in mean of infusions in LGA sessions1.83.38.01.8-1.6-2.1-2.82.52.00.1-0.1-0.81.8
Delay discount exponential model param0.20.31.1-0.10.6-0.00.9-1.0-0.6-0.1-0.10.5-0.5
Extinction: sum of active levers before priming0.10.10.5-0.30.20.10.00.30.1-0.40.5-0.5-0.7
Active lever presses in extinction session 61.91.96.5-0.51.40.31.3-1.5-1.70.8-0.91.3-2.6
Bone: final force0.71.23.00.4-1.1-0.6-1.41.71.7-0.70.7-1.20.5
Bone: final moment0.50.92.20.3-0.8-0.3-1.11.51.4-0.70.8-1.20.4
Food consumed during 24 hour testing period1.42.77.9-2.12.81.81.9-1.9-1.8-0.3-0.10.3-1.1
Glucose0.20.41.4-0.10.6-0.50.5-0.7-0.30.6-1.20.70.0
Heart weight0.30.51.4-1.21.10.50.6-0.5-0.5-0.90.1-0.6-0.3
Delay discount hyperbolic model param0.20.31.10.20.5-0.30.8-1.0-0.60.1-0.30.6-0.5
Intermittent access intake day 1-15 change0.42.45.3-0.71.50.51.8-2.2-2.31.3-0.81.5-1.8
Intermittent access intake escalation0.52.55.6-0.81.90.51.8-2.3-2.41.1-0.91.5-1.5
Intermittent access intake escalation 20.40.71.3-0.80.90.71.0-1.0-1.10.5-0.40.6-0.9
Intermitt. access day 1 inactive lever presses0.11.53.71.1-1.7-0.7-1.91.91.70.50.0-0.50.1
Intermitt. access day 15 inactive lever presses0.10.30.90.6-0.5-1.0-0.70.4-0.20.6-0.70.4-0.3
Intermitt. access escalation Index0.00.10.3-0.30.20.5-0.10.00.1-0.10.0-0.20.6
Intermittent access day 1 total infusions0.30.92.9-1.71.41.10.7-0.3-0.2-0.90.3-0.7-0.5
Intermittent access day 15 total infusions0.51.33.3-1.61.80.81.2-1.2-1.3-0.1-0.20.1-1.2
Intermittent access terminal intake (last 3 days)0.81.43.6-1.91.71.21.2-1.1-1.2-0.50.2-0.3-1.1
Intermittent access total infusions1.21.44.0-2.01.61.41.3-1.0-1.0-0.70.4-0.5-0.9
Intermittent access day 1 locomotion0.10.20.6-0.60.80.2-0.40.50.6-0.2-0.3-0.40.4
Intermittent access day 15 total locomotion0.31.12.7-0.81.60.40.8-0.9-1.11.0-1.21.0-1.4
Intermittent access total locomotion0.40.51.9-1.11.40.70.6-0.5-0.5-0.2-0.2-0.1-0.6
Intermittent access standard deviation0.10.73.0-0.30.10.60.9-1.0-1.10.30.70.2-1.7
Left kidney weight0.10.82.9-0.9-0.21.11.2-0.70.1-0.91.7-0.7-0.5
Right kidney weight0.21.54.6-1.0-0.51.81.0-0.20.6-1.72.1-1.40.1
Cocaine induced anxiety0.92.65.72.0-1.9-1.7-2.42.31.60.9-0.90.00.6
Post-drug Anxiety2.12.45.11.8-1.6-1.6-2.22.31.6-0.3-0.1-0.81.4
Baseline Anxiety0.60.93.0-0.91.00.80.6-0.30.1-1.71.2-1.20.7
Tail length1.26.316.8-2.01.12.50.70.40.9-4.13.5-3.62.8
Length with tail1.35.715.0-1.90.72.20.60.41.3-3.93.6-3.62.1
Length without tail0.10.40.9-0.1-0.10.2-0.20.30.9-0.80.8-1.00.8
Times rat made contact with spout0.30.41.00.3-0.30.3-0.60.80.9-0.20.5-0.71.0
Lifetime Intake1.41.74.4-2.11.81.51.5-1.2-1.2-0.70.4-0.4-1.0
Liver weight, left0.71.13.00.0-1.10.7-0.91.11.7-0.71.0-1.21.3
Liver weight, right1.42.44.50.6-2.00.1-1.01.42.1-1.32.1-1.61.9
Locomotor activity0.30.51.4-0.70.60.51.2-0.8-0.6-0.40.6-0.0-1.2
Locomotor testing distance0.71.83.3-1.81.31.61.8-1.0-0.5-1.31.6-0.8-0.9
Locomotor testing rearing0.41.33.8-1.40.51.20.9-0.10.3-1.62.0-1.40.1
Locomotion in novel chamber0.71.03.6-0.1-0.20.00.2-0.3-0.01.7-1.21.4-1.9
Locomotion in novel chamber post-restriction0.51.44.3-1.52.11.31.2-1.2-1.10.3-0.60.5-1.1
Fecal boli incidents, locomotor time 10.51.35.4-0.2-0.30.6-1.31.30.41.2-1.30.3-2.3
Change in fecal boli incidents, locomotor task0.90.97.60.8-0.5-0.60.2-0.30.3-0.60.20.02.8
Time >=10cm from walls, locomotor time 10.20.31.1-1.00.60.90.4-0.2-0.2-0.70.1-0.40.0
Bouts of movement, locomotor time 10.30.40.9-0.40.10.4-0.70.90.8-0.70.3-1.00.4
Total resting periods, locomotor time 10.10.10.60.0-0.00.1-0.70.80.4-0.0-0.2-0.30.1
Rest time, locomotor task time 10.20.31.10.3-0.0-0.3-0.70.40.2-0.0-0.90.11.1
Distance moved, locomotor task time 10.00.10.5-0.40.00.20.5-0.3-0.1-0.10.7-0.2-0.4
Vertical activity count, locomotor time 10.10.41.6-0.80.00.70.10.30.2-0.41.3-0.8-0.9
Time >=10cm from walls, locomotor time 20.71.95.6-1.70.61.20.7-0.0-0.3-2.41.7-1.91.1
Bouts of movement, locomotor time 20.72.45.7-0.6-1.00.4-0.81.61.5-2.12.1-2.41.6
Total resting periods, locomotor time 20.52.04.0-0.3-1.10.1-1.11.71.6-1.61.7-2.01.6
Rest time, locomotor task time 20.91.53.31.8-1.5-1.6-1.40.90.81.2-1.10.80.8
Distance moved, locomotor task time 21.52.05.0-2.21.61.31.6-1.0-1.3-1.41.4-1.1-0.7
Vertical activity count, locomotor time 20.41.02.6-1.20.21.00.10.5-0.2-1.31.6-1.5-0.8
Light reinforcement 10.52.35.72.1-1.9-2.4-0.80.40.61.8-1.21.60.9
Light reinforcement 21.12.56.11.20.6-1.11.2-1.8-1.62.0-1.72.5-1.1
Bone: marrow area0.92.34.8-1.80.82.20.30.20.4-2.21.7-2.01.4
Bone: maximum diameter1.12.36.2-2.51.41.41.2-0.6-0.5-2.11.8-1.70.4
Bone: maximum force0.20.51.20.2-0.5-0.4-0.91.11.1-0.40.3-0.70.6
Bone: maximum moment0.10.20.6-0.0-0.2-0.2-0.50.70.8-0.40.3-0.60.5
Mean time between licks in bursts0.95.613.8-3.00.82.51.10.20.1-3.73.7-3.40.1
Mean num. licks in bursts0.92.45.8-2.32.41.71.8-1.5-1.4-1.10.6-0.5-1.0
Cd content in liver0.50.61.20.2-0.4-0.1-0.91.11.0-0.60.5-0.91.0
Co content in liver1.51.74.2-1.70.61.60.40.50.3-2.11.8-1.90.4
Cu content in liver1.11.32.7-1.30.21.40.00.60.6-1.61.5-1.71.0
Fe content in liver0.00.00.10.1-0.0-0.1-0.30.30.30.0-0.0-0.10.3
K content in liver0.40.41.00.2-0.70.1-0.30.50.7-0.10.9-0.6-1.0
Mg content in liver0.30.31.6-0.30.40.30.7-0.6-0.50.30.20.3-1.3
Mn content in liver1.41.63.51.6-0.6-1.7-0.5-0.1-0.11.9-1.71.7-0.4
Na content in liver0.80.93.0-0.91.70.71.2-1.3-1.20.0-0.10.3-0.5
Rb content in liver0.20.30.9-0.70.90.6-0.20.40.4-0.40.2-0.70.3
Se content in liver3.44.08.42.9-1.9-2.8-2.21.51.52.1-2.01.31.0
Sr content in liver1.51.33.1-0.10.9-0.21.3-1.7-1.80.9-1.11.5-0.4
Zn content in liver2.02.34.5-2.11.42.11.9-1.5-1.4-1.01.2-0.5-1.2
Bone: minimum diameter1.22.36.2-1.60.11.30.20.60.9-2.22.5-2.30.8
Time in familiar zone, hab. session 10.10.10.2-0.10.10.40.5-0.4-0.3-0.50.5-0.20.4
Time in novel zone, hab. session 10.40.40.80.4-0.8-0.5-0.90.90.9-0.0-0.3-0.20.9
Total zone transitions, hab. session 10.50.61.7-0.21.3-0.60.6-1.1-1.00.5-0.80.9-0.3
Total locomotion distance, hab. session 10.91.22.50.4-1.50.2-0.61.01.2-1.21.6-1.41.0
Locomotion velocity, hab. session 10.60.82.50.3-1.30.1-0.40.81.0-1.01.6-1.20.2
Time in familiar zone, hab. session 21.41.64.8-1.30.62.20.9-0.4-0.4-2.01.4-1.30.3
Time in novel zone, hab. session 21.11.23.70.7-0.1-1.50.1-0.5-0.41.9-1.21.6-1.1
Total zone transitions, hab. session 21.72.25.7-1.42.40.22.0-2.1-2.1-0.30.10.5-1.3
Total locomotion distance, hab. session 21.21.66.9-0.8-0.60.70.60.10.4-1.92.6-1.8-0.4
Locomotion velocity, hab. session 21.31.77.5-0.7-0.70.80.50.20.5-2.02.7-1.9-0.3
Novel to familiar place preference ratio1.01.33.3-0.4-0.4-0.3-0.91.41.4-1.41.5-1.80.1
Novelty place preference0.91.23.1-0.5-0.3-0.3-0.71.31.2-1.51.6-1.80.0
Time in novel zone, NPP test1.01.33.5-0.6-0.3-0.1-0.61.21.1-1.61.7-1.9-0.1
Total zone transitions, NPP test1.11.74.3-0.61.3-0.21.3-1.6-1.51.2-0.81.4-2.1
Total locomotion distance, NPP test0.40.51.70.2-1.20.20.5-0.20.1-0.11.3-0.2-1.3
Locomotion velocity, NPP test0.30.51.90.5-1.4-0.20.3-0.10.20.21.0-0.0-1.1
Intraocular pressure0.81.25.60.20.9-0.7-0.1-0.6-0.71.4-2.41.70.0
Delta distance traveled before/after self-admin0.70.73.1-1.11.80.50.7-0.7-0.8-0.5-0.0-0.0-1.0
Delta ambulatory time before/after self-admin0.40.73.0-0.91.70.50.7-0.7-0.9-0.2-0.30.2-1.0
Parametrial fat weight0.71.64.51.3-0.5-1.40.5-1.3-0.71.9-1.22.10.8
Pavlov. Cond. lever latency0.91.13.81.9-1.3-1.6-0.50.20.20.9-0.81.00.5
Pavlov. Cond. magazine entry latency2.73.59.3-2.72.13.02.0-1.7-1.5-1.41.2-0.8-0.8
Pavlov. Cond. change in total contacts1.11.23.1-1.71.21.80.30.10.0-1.30.8-1.30.3
Pavlov. Cond. index score2.02.56.6-2.52.02.61.4-1.0-1.0-1.31.0-1.0-0.6
Pavlov. Cond. latency score1.82.36.5-2.61.92.41.2-0.8-0.8-1.31.0-1.1-0.7
Pavlov. Cond. lever contacts0.81.03.2-1.81.31.60.7-0.5-0.5-0.80.6-0.7-0.1
Pavlov. Cond. magazine entry number2.43.08.42.7-2.2-2.9-1.61.21.11.4-1.11.00.5
Pavlov. Cond. intertrial magazine entries0.80.92.71.3-0.8-1.6-1.21.21.00.5-0.30.00.3
Pavlov. Cond. lever-magazine prob. diff.1.62.05.6-2.31.92.41.2-0.9-0.9-1.10.8-0.8-0.4
Pavlov. Cond. response bias1.31.64.5-1.91.62.11.3-1.1-1.0-0.90.7-0.5-0.5
Pavlov. Cond. lever latency12.717.935.56.0-5.2-5.2-5.24.14.23.1-2.81.42.9
Pavlov. Cond. magazine entry latency4.36.111.9-2.22.72.33.5-3.3-3.3-0.10.50.9-3.1
Pavlov. Cond. change in total contacts6.215.126.4-5.15.14.44.9-4.0-4.1-2.72.5-1.1-2.7
Pavlov. Cond. index score8.813.923.0-4.84.54.44.8-3.9-4.0-2.32.3-0.9-3.3
Pavlov. Cond. latency score7.812.521.5-4.54.34.04.6-3.8-4.0-1.92.0-0.5-3.2
Pavlov. Cond. lever contacts11.216.633.8-5.85.15.04.9-3.7-3.9-3.12.9-1.6-2.8
Pavlov. Cond. magazine entry number6.58.515.53.0-3.6-3.0-3.93.63.70.8-0.9-0.43.1
Pavlov. Cond. intertrial magazine entries0.71.53.6-0.7-0.20.4-0.71.21.3-1.71.5-1.91.5
Pavlov. Cond. lever-magazine prob. diff.8.513.121.7-4.64.34.44.7-3.7-3.9-2.32.3-0.9-3.1
Pavlov. Cond. response bias13.118.131.7-5.65.35.35.3-4.3-4.4-2.72.6-1.1-3.4
Time in closed arm before self-admin1.01.83.6-1.01.90.61.8-1.9-1.9-0.50.30.3-1.5
Time in closed arm after self-admin0.50.51.10.9-1.0-1.1-0.90.70.80.5-0.40.4-0.1
Time in open arm before self-admin2.53.05.62.1-2.4-1.9-1.81.21.22.2-1.81.50.6
Time in open arm after self-admin0.20.21.6-0.40.10.60.00.1-0.1-0.40.2-0.41.3
Bone: periosteal estimation0.71.63.5-1.90.81.60.6-0.10.2-1.71.6-1.60.7
Bone: periosteal perimeter0.81.64.0-2.01.11.61.1-0.7-0.5-1.41.5-1.20.1
Bone: post-yield work0.10.10.3-0.30.00.30.3-0.1-0.1-0.60.4-0.30.4
Progressive ratio test 1 active lever presses0.10.10.4-0.10.60.0-0.1-0.0-0.20.2-0.70.30.2
Progressive ratio test 1 breakpoint0.10.10.5-0.10.60.0-0.10.0-0.20.2-0.70.20.4
Progressive ratio test 1 inactive lever presses0.10.20.50.1-0.0-0.2-0.60.60.60.5-0.70.1-0.1
Progressive ratio test 2 active lever presses0.20.31.1-1.01.10.50.3-0.1-0.1-0.30.0-0.4-0.2
Progressive ratio test 2 breakpoint0.20.31.3-1.01.10.60.4-0.1-0.1-0.3-0.0-0.4-0.2
Progressive ratio test 2 inactive lever presses0.10.42.2-0.60.80.10.4-0.3-0.60.3-0.40.2-1.5
Incentive Sensitization - Responses0.20.41.2-1.10.90.70.6-0.1-0.0-0.60.5-0.7-0.6
Incentive Sensitization - Breakpoint0.20.41.0-1.01.00.60.7-0.3-0.2-0.40.4-0.4-0.8
Sum of active levers in priming session hrs 5-60.30.30.8-0.20.4-0.30.6-0.6-0.9-0.00.10.1-0.9
Progressive ratio0.51.42.6-0.51.50.81.3-1.6-1.60.9-0.91.2-1.0
Food seeking constrained by brief footshock1.31.63.1-1.60.91.61.4-1.0-1.1-1.51.7-1.00.2
Seeking ratio, punishment vs. effort0.61.45.2-0.9-0.30.80.30.30.4-1.92.3-1.80.4
Retroperitoneal fat weight0.73.19.31.9-3.0-0.7-1.01.12.50.21.5-0.52.6
Reaction time number correct0.10.51.40.30.3-1.20.3-0.6-0.50.6-0.50.7-1.2
Reaction time mean minus median0.10.81.8-1.30.31.30.5-0.10.1-1.01.2-1.0-0.7
Reaction time mean minus median AUC0.10.71.6-1.30.61.10.6-0.2-0.1-0.80.9-0.8-1.2
Reaction time num false alarms1.72.96.91.5-2.5-1.0-2.02.42.60.10.4-0.71.4
Reaction time num false alarms AUC0.92.15.41.2-2.1-0.8-1.82.22.30.30.1-0.50.6
Reaction time trials correct on left0.10.51.40.30.3-1.20.3-0.6-0.50.6-0.50.7-1.2
Reaction time trials on left0.10.51.50.30.2-1.10.3-0.7-0.50.6-0.50.7-1.2
Reaction time mean0.81.74.20.7-1.9-0.2-1.82.11.7-0.41.0-1.30.1
Reaction time mean AUC0.71.74.51.0-1.8-0.5-2.02.11.7-0.20.7-1.10.1
Median of all reaction times1.42.25.41.3-2.3-0.6-2.22.31.9-0.10.6-1.10.2
Reaction time omissions0.20.30.8-0.0-0.70.4-0.30.40.90.10.7-0.4-0.4
Reaction time false alarm rate1.52.05.11.1-2.2-0.3-1.72.12.30.20.3-0.61.0
Reaction time premature initiation rate1.32.15.0-1.80.62.21.1-0.5-0.6-1.91.9-1.60.9
Reaction time premature initiations0.41.12.1-1.40.71.41.1-0.8-0.8-1.21.3-0.9-0.1
Std. dev. reaction times0.51.64.0-0.9-0.71.2-0.71.41.3-1.51.8-2.00.3
Reaction time trials completed0.10.51.50.30.2-1.10.3-0.7-0.50.6-0.50.7-1.2
Reaction time trials AUC0.10.31.10.20.1-1.00.3-0.6-0.30.4-0.30.5-1.1
Run reversals in cocaine runway, females0.80.93.3-0.4-0.40.90.5-0.10.5-1.21.8-1.11.3
Run reversals in cocaine runway, males0.30.30.80.4-0.00.2-0.80.60.40.7-0.90.30.1
Latency to leave start box in cocaine runway1.21.74.71.6-1.7-1.3-1.61.40.70.3-0.3-0.12.2
Latency to leave start box in cocaine runway, F1.72.15.51.2-1.8-1.1-1.81.91.2-0.50.4-1.02.3
Latency to leave start box in cocaine runway, M0.60.51.60.8-0.3-0.5-0.1-0.2-0.51.2-1.11.20.1
Std. dev. time between licks in bursts1.42.67.3-1.6-0.31.70.20.70.7-2.42.7-2.50.1
Total sessions with >9 infusions1.61.94.3-2.12.01.91.6-1.3-1.1-1.00.6-0.5-0.8
Short access day 1 total inactive lever presses0.10.30.8-0.20.10.2-0.70.90.3-0.40.3-0.9-0.4
Short access day 10 total inactive lever presses0.11.02.40.9-1.4-0.6-1.61.51.10.7-0.4-0.10.1
Short access day 1 total infusions1.42.86.6-2.61.82.21.4-0.8-0.8-1.81.6-1.5-1.3
Short access day 10 total infusions1.11.84.5-2.12.01.81.5-1.2-1.0-0.80.5-0.5-0.7
Short access total infusions1.42.04.8-2.22.01.81.5-1.3-1.2-1.00.6-0.6-0.7
Short access day 1 locomotion0.91.44.2-1.42.11.31.0-1.0-0.80.3-0.80.5-1.7
Short access day 10 total locomotion0.41.53.0-1.61.61.51.3-1.1-1.1-0.10.6-0.1-1.7
Short access total locomotion0.40.62.0-0.81.40.60.6-0.7-0.70.5-0.70.6-0.9
One hour access (0.3 mA shock)0.91.02.6-1.61.21.31.2-1.0-1.00.0-0.10.2-1.1
Compulsive drug intake1.21.84.11.5-0.5-1.8-0.70.10.11.9-2.01.8-0.7
One hour access (shock baseline)0.92.34.8-2.21.71.91.9-1.5-1.6-0.70.9-0.4-1.5
Social response proportion0.40.52.10.6-1.5-0.5-0.30.51.00.20.7-0.2-0.7
Social responses1.21.65.10.0-1.60.2-0.61.22.2-0.91.9-1.4-0.1
Social time1.32.07.12.3-1.6-2.7-1.31.00.91.2-0.70.7-0.0
Soleus weight0.51.63.2-0.0-1.70.8-0.81.31.7-1.01.8-1.60.9
Bone: stiffness1.22.35.10.6-1.6-0.5-1.92.22.3-0.91.1-1.71.1
Tibialis anterior weight0.20.72.0-0.5-0.50.8-0.10.60.8-1.11.4-1.30.5
Time to tail flick, vehicle, before self-admin0.60.72.2-0.41.20.11.2-1.5-1.30.0-0.00.30.2
Time to tail flick, vehicle, after self-admin0.20.51.7-1.11.30.70.3-0.2-0.8-0.80.1-0.6-0.0
Time to tail flick, test, before self-admin1.31.54.6-1.11.11.20.7-0.2-0.1-1.80.9-1.32.1
Time to tail flick, test, after self-admin1.51.64.2-1.0-0.11.2-0.10.60.3-2.01.7-2.01.5
Delta time to tail flick, vehicle, before/after SA0.20.20.6-0.50.20.7-0.60.80.3-0.2-0.2-0.4-0.4
Delta time to tail flick, test, before/after SA0.30.41.60.6-1.3-0.7-0.60.30.30.60.00.3-0.4
Tibia length0.61.75.2-1.72.11.60.9-0.7-0.7-0.60.4-0.5-2.3
Ambulatory time before self-admin0.20.51.51.2-1.0-1.1-0.1-0.2-0.10.7-0.40.8-0.1
Ambulatory time after self-admin0.71.22.20.60.7-0.90.8-1.3-1.50.8-0.91.4-1.3
Bone: tissue strength1.81.84.51.30.2-1.50.3-0.9-0.92.0-1.92.1-0.9
Total heroin consumption0.40.52.6-0.40.4-0.00.9-0.8-0.5-0.10.60.1-1.6
Bone: trabecular number0.71.43.11.4-0.2-1.5-0.80.20.11.6-1.81.40.8
Bone: trabecular spacing1.11.64.6-0.91.20.91.6-1.7-1.50.40.00.7-2.2
Bone: trabecular thickness1.21.63.10.5-1.0-0.6-1.41.81.7-1.10.8-1.41.6
Bone: trabecular tissue density2.74.79.90.9-2.5-0.9-2.43.03.1-1.52.0-2.51.3
Water consumed over 24 hours0.10.30.50.7-0.2-0.6-0.60.30.50.6-0.60.40.5
Number of responses in last shaping day1.31.74.20.2-1.30.0-1.62.02.0-0.70.7-1.41.3