LOC120097342

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	gene expression	LOC120097342	0.15	0.11	4.8e-06	0.03	0.03	0.03	0.03	3.5e-04	1.5e-04	4.4e-04	5.0e-04
2	Adipose	alternative polyA	XR_005494590.2	0.04	0.03	2.7e-03	0.01	0.01	0.01	0.01	7.6e-03	9.6e-03	7.5e-03	8.9e-03
3	Brain	gene expression	LOC120097342	0.06	0.05	1.4e-05	0.04	0.04	0.04	0.04	7.7e-05	1.8e-04	2.4e-04	2.0e-04
4	Brain	isoform ratio	XR_005494587.2	0.07	0.07	1.6e-04	0.04	0.03	0.03	0.04	1.3e-04	1.1e-03	4.0e-04	3.1e-04
5	Brain	alternative polyA	XR_010060654.1	0.17	0.16	2.9e-03	0.01	0.01	0.02	0.01	1.3e-02	1.5e-02	8.2e-03	3.3e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5
Bone: apparent density	0.5	0.9	1.8	-1.2	0.6	-0.6	-0.6	-1.4
Area under the delay curve	0.5	0.5	0.9	1.0	-0.9	0.8	0.6	0.2
BMI with tail	0.1	0.4	0.6	-0.8	0.5	-0.5	-0.3	-0.8
BMI without tail	1.2	3.6	5.2	-2.3	1.8	-1.7	-1.6	-2.0
Body weight	0.8	3.6	5.6	-2.4	2.0	-2.0	-1.8	-1.0
Weight adjusted by age	1.6	2.5	3.3	-1.6	1.8	-1.7	-1.8	-0.6
Bone surface	0.6	1.1	1.5	-1.2	0.9	-0.9	-0.9	-1.2
Bone volume	0.4	0.8	1.1	-1.1	0.8	-0.7	-0.8	-1.0
Breakpoint value in progressive ratio session	1.7	2.0	2.6	1.6	-1.6	1.6	1.5	0.1
Number of licking bursts	0.3	0.4	0.7	-0.8	0.8	-0.8	-0.4	-0.2
Context. condit. distance diff. score	1.0	1.3	2.0	1.0	-1.4	1.4	1.2	-0.1
Locomotion velocity, session 1	1.2	1.3	1.8	1.3	-1.2	1.2	1.0	0.8
Locomotion distance, session 1	1.1	1.3	2.2	1.3	-1.4	1.5	0.7	0.5
Locomotion velocity, session 2	1.2	1.4	1.7	1.3	-1.2	1.2	1.0	1.2
Locomotion distance, session 2	2.8	3.8	5.3	2.3	-1.9	1.9	1.6	2.1
Locomotion velocity, session 3	0.4	0.5	0.8	-0.5	0.9	-0.9	-0.8	0.2
Locomotion distance, session 3	0.3	0.4	0.6	0.7	-0.5	0.5	0.5	0.7
Stereotopy head waving bouts, day 3	1.5	1.8	2.2	-1.5	1.2	-1.2	-1.5	-1.3
Stereotopy head waving duration, day 3	0.3	0.3	1.5	-0.2	-0.1	0.1	-0.2	-1.2
Locomotion velocity, session 7	3.7	4.0	6.6	2.0	-2.5	2.6	1.7	0.5
Locomotion distance, session 7	5.5	6.9	9.1	2.8	-3.0	3.0	2.4	1.7
Stereotopy head waving bouts, day 7	0.4	0.4	0.8	-0.8	0.4	-0.3	-0.6	-0.9
Stereotopy head waving duration, day 7	0.6	0.7	1.3	-0.9	0.6	-0.6	-0.9	-1.1
Locomotion velocity, session 8	3.3	4.0	5.9	1.7	-2.4	2.4	2.2	0.7
Locomotion distance, session 8	3.4	4.9	6.7	2.3	-2.6	2.6	2.1	1.1
Degree of sensitization distance	0.9	1.0	1.3	1.0	-1.2	1.2	1.0	0.4
Degree of sensitization stereotypy	0.2	0.2	0.3	-0.6	0.3	-0.2	-0.4	-0.6
Conditioned locomotion	0.5	0.5	0.8	0.9	-0.8	0.9	0.6	0.2
Cocaine response after cond. corrected	0.8	1.0	1.3	-1.1	1.2	-1.1	-0.9	0.5
Cocaine response after cond. not corrected	0.2	0.3	0.4	-0.4	0.5	-0.5	-0.4	0.7
Cocaine response before conditioning	0.7	0.8	1.3	1.1	-1.1	1.0	0.7	-0.2
Saline control response	0.2	0.3	0.6	-0.2	0.5	-0.5	-0.6	-0.8
Bone: connectivity density	0.8	1.3	3.9	-1.3	0.6	-0.6	-0.5	-2.0
Bone: cortical apparent density	0.3	0.4	0.6	0.6	-0.8	0.7	0.8	0.0
Bone: cortical area	0.2	0.4	0.7	-0.3	0.6	-0.6	-0.5	0.8
Bone: cortical porosity	0.1	0.1	0.2	-0.5	0.3	-0.3	-0.2	-0.5
Bone: cortical porosity	0.6	0.7	0.9	-1.0	0.8	-0.8	-0.7	-0.8
Bone: cortical thickness	0.4	0.7	2.4	0.7	-0.6	0.5	0.4	1.5
Bone: cortical thickness	2.0	2.3	5.8	1.7	-1.1	1.1	0.8	2.4
Bone: cortical tissue density	0.3	0.4	0.6	0.6	-0.8	0.7	0.8	0.0
Condit. Reinf. active minus inactive responses	0.9	1.0	1.3	-1.2	0.9	-0.9	-1.1	-0.9
Condit. Reinf. active-inactive response ratio	2.8	3.0	4.0	-2.0	1.5	-1.5	-1.6	-2.0
Condit. Reinf. active responses	0.3	0.4	0.8	-0.6	0.6	-0.6	-0.9	-0.5
Condit. Reinf. inactive responses	0.3	0.3	0.6	0.8	-0.5	0.5	0.2	0.8
Incentive salience index mean	0.4	0.5	0.7	-0.8	0.6	-0.6	-0.8	-0.8
Condit. Reinf. lever presses	0.2	0.3	0.4	0.5	-0.6	0.6	0.6	-0.0
Condit. Reinf. active minus inactive responses	3.2	4.2	5.8	2.4	-2.1	2.1	2.1	1.5
Condit. Reinf. active-inactive response ratio	3.4	4.0	4.9	2.1	-2.1	2.1	2.2	1.2
Condit. Reinf. active responses	2.8	4.0	6.6	2.6	-1.9	1.9	1.8	1.8
Condit. Reinf. inactive responses	0.2	0.3	0.6	0.3	0.5	-0.5	-0.8	0.6
Condit. Reinf. lever presses	7.7	10.7	15.9	4.0	-3.5	3.4	3.2	1.9
Condit. Reinf. lever reinforcers received	3.2	4.5	7.0	2.7	-2.0	2.0	1.9	2.0
Conditioned reinforcement - actives	0.5	0.9	3.9	0.2	0.2	-0.2	0.5	2.0
Conditioned reinforcement - inactives	0.8	1.2	1.5	-1.2	1.2	-1.2	-0.9	0.8
Conditioned locomotion	0.3	0.4	0.9	-0.4	0.9	-1.0	-0.4	0.2
Patch foraging indifference point 0 sec	0.6	1.2	1.8	1.3	-1.1	1.0	1.1	0.9
Patch foraging indifference point AUC	0.1	0.2	0.8	-0.2	-0.1	0.1	0.2	-0.9
Delay disc. indifference point, 0s delay	0.9	0.9	1.7	-0.8	1.1	-1.0	-1.3	-0.2
Delay disc. indifference point, 16s delay	2.5	2.7	4.2	2.1	-1.8	1.8	1.6	0.6
Delay disc. indifference point, 2s delay	0.1	0.1	0.3	-0.4	0.2	-0.1	-0.6	-0.3
Delay disc. indifference point, 24s delay	0.9	1.1	1.7	1.3	-1.2	1.2	0.9	0.0
Delay disc. indifference point, 4s delay	0.2	0.3	0.5	-0.7	0.3	-0.3	-0.7	-0.5
Delay disc. indifference point, 8s delay	0.6	0.7	1.6	1.2	-0.8	0.8	0.7	0.0
Indifference point function ln k	2.1	3.6	4.5	2.1	-1.8	1.8	1.6	2.1
Indifference point function log k	2.1	3.6	4.5	2.1	-1.8	1.8	1.6	2.1
Patch foraging total patch changes 0 sec	0.9	1.6	2.4	1.6	-1.2	1.2	1.3	1.1
Patch foraging total patch changes 12 sec	0.7	0.9	2.5	-0.7	0.8	-0.8	-0.6	-1.6
Patch foraging total patch changes 18 sec	0.0	0.0	0.1	0.1	0.0	0.0	0.2	-0.3
Patch foraging total patch changes 24 sec	0.3	0.6	0.9	-0.6	0.9	-0.9	-0.4	-0.7
Patch foraging total patch changes 6 sec	0.1	0.2	0.8	-0.0	0.0	-0.1	0.1	-0.9
Patch foraging time to switch 0 sec	3.7	7.6	8.8	-2.8	2.9	-3.0	-2.8	-2.2
Patch foraging water rate 0 sec	3.3	7.0	8.3	2.8	-2.7	2.7	2.9	2.0
Patch foraging water rate 12 sec	8.4	17.6	20.2	4.4	-4.2	4.3	4.5	3.4
Patch foraging water rate 18 sec	5.5	8.5	9.6	3.0	-3.0	3.1	3.1	2.3
Patch foraging water rate 24 sec	3.5	4.9	6.5	2.1	-2.3	2.4	2.6	1.5
Patch foraging water rate 6 sec	7.3	10.7	11.9	3.4	-3.4	3.5	3.4	2.6
Seeking ratio, delayed vs. immediate footshock	0.3	0.4	0.5	-0.7	0.7	-0.6	-0.6	-0.1
Distance traveled before self-admin	0.2	0.3	0.8	-0.5	0.3	-0.3	-0.5	-0.9
Distance traveled after self-admin	0.6	0.8	1.2	-1.0	0.6	-0.6	-0.9	-1.1
Extensor digitorum longus weight	0.1	0.3	0.6	0.8	-0.6	0.5	0.6	0.1
Bone: elastic displacement	1.9	2.2	3.7	1.5	-1.2	1.2	1.4	1.9
Bone: elastic work	0.7	0.9	1.2	0.8	-0.8	0.8	1.0	1.1
Bone: endosteal estimation	1.4	3.0	3.8	-1.7	1.9	-1.9	-1.7	-1.2
Bone: endosteal perimeter	1.0	2.2	2.9	-1.5	1.7	-1.7	-1.3	-0.9
Epididymis fat weight	0.3	1.0	2.5	-1.3	0.4	-0.4	-0.5	-1.6
Delta time in closed arm before/after self-admin	0.2	0.2	0.3	-0.2	0.5	-0.6	-0.1	-0.4
Delta time in open arm before/after self-admin	0.4	0.4	0.7	0.3	-0.8	0.8	0.6	0.6
Diff in mean of infusions in LGA sessions	0.6	0.7	1.3	0.7	-1.0	1.1	0.8	0.4
Delay discount exponential model param	0.7	0.8	1.2	-1.1	1.0	-1.0	-0.7	-0.3
Extinction: sum of active levers before priming	0.2	0.2	0.3	0.4	-0.5	0.5	0.4	-0.3
Active lever presses in extinction session 6	0.5	0.5	0.8	0.9	-0.7	0.7	0.7	0.4
Bone: final force	0.0	0.1	0.2	0.3	-0.0	0.0	-0.3	0.4
Bone: final moment	0.0	0.1	0.2	0.3	-0.1	0.1	-0.1	0.5
Food consumed during 24 hour testing period	0.5	0.7	1.9	-0.9	0.6	-0.5	-0.5	-1.4
Glucose	0.2	0.4	0.8	0.1	-0.5	0.5	0.6	-0.9
Heart weight	1.6	2.5	3.9	1.7	-1.3	1.3	1.7	2.0
Delay discount hyperbolic model param	0.3	0.4	0.6	-0.7	0.8	-0.7	-0.5	-0.1
Intermittent access intake day 1-15 change	0.3	0.5	0.7	0.7	-0.8	0.8	0.9	0.4
Intermittent access intake escalation	0.1	0.2	0.3	0.2	-0.5	0.5	0.5	-0.2
Intermittent access intake escalation 2	0.1	0.2	0.5	-0.3	0.4	-0.4	-0.1	-0.7
Intermitt. access day 1 inactive lever presses	0.2	0.7	1.0	-0.6	1.0	-1.0	-1.0	0.1
Intermitt. access day 15 inactive lever presses	0.3	0.6	1.1	-0.2	1.0	-1.1	-0.3	0.9
Intermitt. access escalation Index	0.1	0.1	0.3	0.0	-0.4	0.5	0.0	0.3
Intermittent access day 1 total infusions	0.3	0.5	1.9	0.4	0.1	-0.1	0.4	1.4
Intermittent access day 15 total infusions	0.4	0.6	1.1	0.7	-0.5	0.5	1.1	0.8
Intermittent access terminal intake (last 3 days)	0.2	0.3	0.7	0.4	-0.1	0.1	0.8	0.8
Intermittent access total infusions	0.4	0.4	1.0	0.5	-0.2	0.2	0.9	1.0
Intermittent access day 1 locomotion	0.2	0.3	0.5	-0.2	0.7	-0.7	-0.5	0.2
Intermittent access day 15 total locomotion	0.1	0.2	0.3	0.6	-0.2	0.1	0.4	0.5
Intermittent access total locomotion	0.1	0.1	0.4	-0.1	0.5	-0.6	-0.1	-0.1
Intermittent access standard deviation	0.1	0.2	0.6	-0.1	0.3	-0.3	0.2	0.8
Left kidney weight	0.3	1.2	1.8	-1.2	1.3	-1.3	-0.9	0.2
Right kidney weight	0.1	0.6	0.8	-0.9	0.9	-0.9	-0.6	0.5
Cocaine induced anxiety	0.8	1.1	1.8	-0.8	1.3	-1.3	-0.8	-0.9
Post-drug Anxiety	0.0	0.1	0.2	0.2	-0.1	0.0	0.4	0.2
Baseline Anxiety	2.1	2.4	3.2	1.3	-1.6	1.6	1.4	1.8
Tail length	1.3	5.1	7.0	-2.6	2.4	-2.4	-2.3	-1.5
Length with tail	0.7	3.2	4.8	-2.2	1.9	-1.8	-1.9	-0.8
Length without tail	0.4	1.2	1.6	-1.2	1.2	-1.2	-1.2	0.2
Times rat made contact with spout	0.2	0.2	0.3	0.1	-0.5	0.5	0.5	-0.1
Lifetime Intake	0.5	0.6	1.7	0.6	-0.2	0.2	0.9	1.3
Liver weight, left	4.9	8.1	11.7	-3.4	2.8	-2.7	-2.6	-2.7
Liver weight, right	2.1	3.7	5.2	-2.3	1.8	-1.7	-1.7	-2.0
Locomotor activity	1.4	2.2	2.8	1.7	-1.5	1.5	1.5	1.0
Locomotor testing distance	0.6	1.0	1.6	1.3	-1.0	0.9	0.9	0.9
Locomotor testing rearing	0.2	0.5	1.0	0.7	-0.6	0.5	0.5	1.0
Locomotion in novel chamber	0.6	0.8	1.2	1.0	-0.9	0.9	1.1	0.1
Locomotion in novel chamber post-restriction	5.5	9.0	11.9	3.0	-3.5	3.4	3.2	1.5
Fecal boli incidents, locomotor time 1	1.5	2.1	3.0	-1.3	1.7	-1.7	-1.6	-0.7
Change in fecal boli incidents, locomotor task	1.2	1.1	1.8	0.8	-1.3	1.2	1.3	0.3
Time >=10cm from walls, locomotor time 1	0.4	0.5	1.3	-0.4	0.5	-0.5	-0.6	-1.1
Bouts of movement, locomotor time 1	0.0	0.0	0.1	0.1	0.2	-0.2	-0.0	-0.3
Total resting periods, locomotor time 1	0.1	0.2	0.3	0.6	-0.3	0.3	0.5	-0.0
Rest time, locomotor task time 1	0.3	0.4	0.5	0.7	-0.6	0.5	0.7	0.6
Distance moved, locomotor task time 1	0.3	0.5	0.8	-0.9	0.7	-0.6	-0.8	-0.5
Vertical activity count, locomotor time 1	0.3	0.7	1.3	-1.1	0.7	-0.6	-0.7	-0.9
Time >=10cm from walls, locomotor time 2	0.6	0.9	2.0	-0.8	0.9	-0.9	-1.4	-0.7
Bouts of movement, locomotor time 2	0.2	0.3	0.5	0.1	0.6	-0.7	-0.6	0.1
Total resting periods, locomotor time 2	0.2	0.3	0.6	0.2	0.7	-0.7	-0.6	0.2
Rest time, locomotor task time 2	0.2	0.2	0.7	0.0	0.4	-0.4	-0.1	0.9
Distance moved, locomotor task time 2	1.2	1.5	2.7	-1.4	1.0	-1.0	-1.6	-1.0
Vertical activity count, locomotor time 2	1.9	2.6	3.5	-1.9	1.6	-1.5	-1.8	-1.3
Light reinforcement 1	0.1	0.2	0.4	-0.3	0.6	-0.7	-0.5	-0.1
Light reinforcement 2	0.2	0.3	1.0	-0.4	0.4	-0.3	-0.2	1.0
Bone: marrow area	1.3	2.9	3.6	-1.7	1.9	-1.9	-1.7	-1.2
Bone: maximum diameter	0.4	0.8	1.3	-0.7	1.1	-1.1	-0.8	0.5
Bone: maximum force	0.1	0.1	0.2	0.4	-0.3	0.3	0.1	0.4
Bone: maximum moment	0.1	0.2	0.3	0.5	-0.5	0.5	0.4	0.5
Mean time between licks in bursts	0.1	0.1	0.2	-0.4	0.5	-0.5	-0.2	0.0
Mean num. licks in bursts	0.5	0.8	1.4	0.8	-1.1	1.2	0.7	-0.0
Cd content in liver	0.4	0.5	1.0	-0.7	0.6	-0.6	-1.0	0.1
Co content in liver	0.4	0.5	2.1	0.6	0.1	-0.1	-0.0	1.4
Cu content in liver	3.0	3.5	5.6	-1.6	2.0	-2.0	-2.4	-1.2
Fe content in liver	0.0	0.0	0.0	0.1	0.1	-0.1	-0.1	-0.0
K content in liver	1.6	1.6	2.3	-1.0	1.5	-1.5	-1.5	-0.1
Mg content in liver	1.3	1.4	2.3	-0.9	1.4	-1.3	-1.5	-0.4
Mn content in liver	1.2	1.3	2.0	-0.8	1.4	-1.4	-1.4	-0.0
Na content in liver	2.0	2.1	2.5	-1.3	1.6	-1.6	-1.6	-1.1
Rb content in liver	1.6	1.9	3.1	-1.1	1.3	-1.3	-1.4	-1.8
Se content in liver	2.5	3.0	4.3	-1.5	2.1	-2.1	-2.0	-0.3
Sr content in liver	0.3	0.2	0.3	0.5	-0.5	0.5	0.5	0.0
Zn content in liver	0.1	0.1	0.2	0.4	0.1	-0.1	-0.3	0.1
Bone: minimum diameter	2.3	4.1	5.3	-2.3	2.2	-2.2	-1.9	-1.5
Time in familiar zone, hab. session 1	0.2	0.2	0.2	0.2	-0.5	0.5	0.4	-0.4
Time in novel zone, hab. session 1	0.2	0.2	0.5	0.6	0.0	-0.1	-0.2	0.7
Total zone transitions, hab. session 1	0.4	0.6	1.2	1.0	-0.5	0.5	0.6	1.1
Total locomotion distance, hab. session 1	2.3	3.3	4.8	-1.6	2.2	-2.2	-2.1	-0.3
Locomotion velocity, hab. session 1	3.0	4.3	5.8	-2.2	2.4	-2.4	-2.2	-0.5
Time in familiar zone, hab. session 2	0.6	0.7	1.1	0.9	-1.0	1.0	0.4	0.5
Time in novel zone, hab. session 2	0.4	0.4	0.8	-0.7	0.8	-0.9	-0.4	-0.4
Total zone transitions, hab. session 2	0.8	1.0	1.4	1.2	-1.0	1.0	1.0	0.7
Total locomotion distance, hab. session 2	1.1	1.5	2.1	-1.2	1.4	-1.4	-1.3	-0.2
Locomotion velocity, hab. session 2	1.0	1.4	2.1	-1.0	1.4	-1.5	-1.3	0.1
Novel to familiar place preference ratio	0.1	0.1	0.5	0.3	-0.2	0.2	0.1	0.7
Novelty place preference	0.3	0.3	0.9	0.6	-0.4	0.4	0.2	0.9
Time in novel zone, NPP test	0.7	0.8	1.4	1.0	-0.8	0.8	0.6	1.2
Total zone transitions, NPP test	0.8	1.2	1.8	1.0	-1.3	1.3	1.2	0.2
Total locomotion distance, NPP test	0.9	1.2	1.6	-1.3	1.2	-1.2	-1.1	-0.5
Locomotion velocity, NPP test	1.2	1.7	2.2	-1.5	1.5	-1.4	-1.4	-0.5
Intraocular pressure	0.7	1.0	1.4	1.0	-1.1	1.1	1.2	0.1
Delta distance traveled before/after self-admin	0.0	0.0	0.1	0.1	-0.3	0.3	0.1	0.1
Delta ambulatory time before/after self-admin	0.1	0.1	0.3	0.3	-0.5	0.5	0.3	0.1
Parametrial fat weight	0.1	0.2	0.4	-0.3	-0.4	0.5	0.6	0.4
Pavlov. Cond. lever latency	0.3	0.3	0.8	-0.1	0.6	-0.7	0.0	0.9
Pavlov. Cond. magazine entry latency	1.7	2.2	2.9	1.6	-1.7	1.7	1.3	1.2
Pavlov. Cond. change in total contacts	0.2	0.2	0.6	0.1	-0.7	0.8	0.2	-0.3
Pavlov. Cond. index score	0.6	0.7	1.2	0.9	-1.1	1.1	0.6	0.3
Pavlov. Cond. latency score	0.3	0.3	0.6	0.6	-0.8	0.8	0.3	0.1
Pavlov. Cond. lever contacts	0.2	0.2	0.5	0.1	-0.4	0.4	-0.2	-0.7
Pavlov. Cond. magazine entry number	1.5	1.9	2.8	-1.5	1.7	-1.6	-1.2	-0.9
Pavlov. Cond. intertrial magazine entries	0.5	0.6	0.9	-0.9	0.6	-0.5	-0.9	-0.9
Pavlov. Cond. lever-magazine prob. diff.	0.7	0.9	1.5	0.8	-1.2	1.2	0.7	0.2
Pavlov. Cond. response bias	0.6	0.8	1.4	0.8	-1.2	1.2	0.7	0.1
Pavlov. Cond. lever latency	14.9	20.3	27.1	-5.2	4.7	-4.7	-4.4	-3.2
Pavlov. Cond. magazine entry latency	5.1	6.2	7.8	2.6	-2.8	2.8	2.6	1.3
Pavlov. Cond. change in total contacts	7.1	11.4	15.6	3.9	-3.4	3.4	3.4	2.6
Pavlov. Cond. index score	9.8	13.2	17.1	4.1	-3.8	3.8	3.6	2.6
Pavlov. Cond. latency score	9.5	12.6	15.9	4.0	-3.8	3.8	3.6	2.3
Pavlov. Cond. lever contacts	13.1	18.1	24.3	4.9	-4.5	4.4	4.2	3.0
Pavlov. Cond. magazine entry number	7.5	9.3	11.2	-3.3	3.3	-3.2	-3.2	-1.9
Pavlov. Cond. intertrial magazine entries	2.4	3.7	5.1	-1.9	2.3	-2.2	-2.0	-0.9
Pavlov. Cond. lever-magazine prob. diff.	8.5	11.4	14.5	3.8	-3.6	3.6	3.4	2.3
Pavlov. Cond. response bias	14.0	19.0	25.7	5.1	-4.5	4.4	4.2	3.4
Time in closed arm before self-admin	0.1	0.1	0.3	0.0	-0.5	0.6	0.1	-0.2
Time in closed arm after self-admin	0.4	0.5	2.0	-0.5	-0.0	0.1	-0.3	-1.4
Time in open arm before self-admin	0.6	0.6	1.3	-0.2	1.1	-1.2	-0.6	0.5
Time in open arm after self-admin	0.1	0.1	0.6	0.1	0.0	-0.1	0.1	0.8
Bone: periosteal estimation	1.0	2.1	3.0	-1.5	1.7	-1.7	-1.5	-0.4
Bone: periosteal perimeter	0.3	0.5	0.8	-0.5	0.9	-0.9	-0.5	0.4
Bone: post-yield work	0.0	0.0	0.1	0.2	-0.3	0.2	0.1	-0.3
Progressive ratio test 1 active lever presses	0.5	0.6	2.9	0.2	0.2	-0.2	0.5	1.7
Progressive ratio test 1 breakpoint	0.4	0.5	2.3	0.0	0.3	-0.3	0.3	1.5
Progressive ratio test 1 inactive lever presses	0.5	0.7	2.1	-0.4	0.7	-0.7	-0.5	1.5
Progressive ratio test 2 active lever presses	0.3	0.4	1.1	0.4	-0.2	0.1	0.8	1.0
Progressive ratio test 2 breakpoint	0.4	0.4	1.1	0.4	-0.2	0.2	0.9	1.0
Progressive ratio test 2 inactive lever presses	0.8	1.2	3.0	1.0	-0.6	0.5	1.3	1.7
Incentive Sensitization - Responses	0.0	0.0	0.1	0.2	-0.2	0.2	0.3	-0.0
Incentive Sensitization - Breakpoint	0.1	0.2	0.3	0.4	-0.4	0.4	0.5	0.1
Sum of active levers in priming session hrs 5-6	1.6	1.5	2.3	1.1	-1.4	1.5	1.2	0.7
Progressive ratio	0.1	0.1	0.4	0.3	0.2	-0.3	-0.1	0.7
Food seeking constrained by brief footshock	0.4	0.4	1.3	-0.5	0.4	-0.3	-0.7	-1.1
Seeking ratio, punishment vs. effort	1.0	1.5	3.3	-1.4	0.8	-0.6	-1.1	-1.8
Retroperitoneal fat weight	0.9	4.0	8.1	-2.9	1.7	-1.6	-1.7	-1.9
Reaction time number correct	0.0	0.1	0.1	0.3	-0.2	0.2	0.1	0.3
Reaction time mean minus median	0.1	0.4	0.7	0.7	-0.5	0.4	0.5	0.8
Reaction time mean minus median AUC	0.0	0.1	0.2	0.3	-0.2	0.2	0.3	0.4
Reaction time num false alarms	2.1	2.9	3.8	-1.8	1.9	-2.0	-1.9	-0.5
Reaction time num false alarms AUC	1.3	2.0	2.6	-1.6	1.6	-1.6	-1.4	-0.7
Reaction time trials correct on left	0.0	0.1	0.1	0.3	-0.2	0.2	0.1	0.3
Reaction time trials on left	0.0	0.1	0.1	0.3	-0.2	0.3	0.2	0.4
Reaction time mean	0.1	0.1	0.5	0.0	0.3	-0.3	0.1	0.7
Reaction time mean AUC	0.1	0.2	0.3	-0.3	0.5	-0.6	-0.1	0.3
Median of all reaction times	0.1	0.2	0.4	-0.1	0.4	-0.5	0.1	0.6
Reaction time omissions	0.2	0.3	0.5	0.6	-0.6	0.6	0.7	0.4
Reaction time false alarm rate	0.9	1.2	1.6	-1.3	1.2	-1.3	-1.0	-0.5
Reaction time premature initiation rate	0.4	0.6	1.0	1.0	-0.7	0.7	0.8	0.6
Reaction time premature initiations	0.5	0.8	1.2	1.1	-0.9	0.9	0.9	0.6
Std. dev. reaction times	0.0	0.1	0.3	0.3	0.1	-0.1	0.1	0.6
Reaction time trials completed	0.0	0.1	0.1	0.3	-0.2	0.3	0.2	0.4
Reaction time trials AUC	0.0	0.1	0.2	0.4	-0.2	0.3	0.1	0.4
Run reversals in cocaine runway, females	0.1	0.1	0.3	-0.4	0.2	-0.2	-0.5	-0.5
Run reversals in cocaine runway, males	3.5	3.5	4.8	1.8	-2.2	2.2	2.0	1.0
Latency to leave start box in cocaine runway	2.9	3.3	5.7	-1.6	2.3	-2.4	-1.7	-0.2
Latency to leave start box in cocaine runway, F	4.0	4.5	7.0	-1.9	2.6	-2.6	-2.2	-0.6
Latency to leave start box in cocaine runway, M	0.2	0.2	0.4	-0.2	0.6	-0.6	-0.1	0.3
Std. dev. time between licks in bursts	1.2	1.6	2.1	-1.4	1.3	-1.3	-1.2	-1.1
Total sessions with >9 infusions	0.3	0.3	1.4	0.1	0.3	-0.4	0.1	1.2
Short access day 1 total inactive lever presses	0.2	0.2	0.7	0.3	0.1	-0.1	0.6	0.8
Short access day 10 total inactive lever presses	0.2	0.4	1.2	-0.4	0.3	-0.3	-0.6	-1.1
Short access day 1 total infusions	0.1	0.1	0.4	0.2	-0.1	0.1	0.4	0.6
Short access day 10 total infusions	0.3	0.4	0.7	-0.4	0.8	-0.8	-0.3	0.8
Short access total infusions	0.3	0.4	1.6	0.2	0.3	-0.3	0.3	1.3
Short access day 1 locomotion	0.5	0.6	2.1	0.7	-0.1	0.1	0.6	1.4
Short access day 10 total locomotion	0.0	0.1	0.2	0.2	0.2	-0.2	0.0	-0.4
Short access total locomotion	0.3	0.3	0.6	-0.2	0.8	-0.8	-0.5	0.3
One hour access (0.3 mA shock)	1.2	1.4	2.4	1.3	-0.8	0.8	1.3	1.5
Compulsive drug intake	0.4	0.5	0.8	0.6	-0.9	0.9	0.4	0.8
One hour access (shock baseline)	0.7	1.1	1.9	1.2	-0.7	0.7	1.4	1.0
Social response proportion	0.2	0.3	0.6	-0.3	0.5	-0.6	-0.1	-0.8
Social responses	0.2	0.2	0.5	0.7	-0.3	0.2	0.7	-0.2
Social time	1.3	1.7	2.5	-1.3	1.5	-1.6	-1.0	-1.1
Soleus weight	0.5	1.5	2.1	-1.2	1.4	-1.5	-1.4	-0.3
Bone: stiffness	0.0	0.0	0.0	-0.0	-0.0	0.0	-0.2	0.1
Tibialis anterior weight	0.1	0.2	0.5	0.5	-0.2	0.2	0.3	0.7
Time to tail flick, vehicle, before self-admin	0.6	0.6	0.8	0.9	-0.8	0.8	0.8	0.3
Time to tail flick, vehicle, after self-admin	0.3	0.3	0.5	0.6	-0.6	0.6	0.5	0.7
Time to tail flick, test, before self-admin	1.1	1.1	1.4	-1.1	1.1	-1.0	-1.2	-0.9
Time to tail flick, test, after self-admin	2.7	2.8	3.9	-1.4	1.9	-2.0	-1.7	-1.1
Delta time to tail flick, vehicle, before/after SA	0.1	0.1	0.5	0.2	-0.1	0.1	0.1	0.7
Delta time to tail flick, test, before/after SA	0.4	0.4	0.9	-0.4	0.9	-0.9	-0.5	-0.2
Tibia length	0.8	2.1	3.1	-1.2	1.7	-1.7	-1.6	-0.7
Ambulatory time before self-admin	0.1	0.1	0.6	-0.3	-0.0	0.0	-0.1	-0.8
Ambulatory time after self-admin	0.1	0.1	0.5	-0.2	-0.2	0.2	0.0	-0.7
Bone: tissue strength	0.8	0.8	2.4	-0.3	-0.7	0.7	0.7	-1.5
Total heroin consumption	2.1	2.5	3.3	1.7	-1.8	1.8	1.7	0.4
Bone: trabecular number	0.3	0.5	1.8	-0.7	0.2	-0.2	-0.3	-1.3
Bone: trabecular spacing	0.1	0.1	0.2	0.4	-0.2	0.2	0.4	0.1
Bone: trabecular thickness	0.1	0.1	0.2	-0.4	0.3	-0.3	-0.3	0.1
Bone: trabecular tissue density	0.5	0.8	1.1	-0.3	1.0	-1.0	-0.9	0.9
Water consumed over 24 hours	0.1	0.1	0.2	-0.0	-0.4	0.4	0.3	-0.5
Number of responses in last shaping day	3.0	3.3	3.9	-1.8	2.0	-1.9	-1.8	-1.5