Total sessions with >9 infusions

Tags: Behavior · Cocaine · Short access

Project: p50_paul_meyer_2020

2 loci · 2 genes with independent associations · 2 total associated genes

Significant Loci

#	Chr	Start pos	End pos	# assoc genes	# joint models	Best TWAS P	Best GWAS P	Cond GWAS P	Joint genes
1	chr4	95890735	97085238	1	1	2.90e-11	4.14e-01	1.23e-41	Serbp1
2	chr19	32676171	34074113	1	1	3.08e-13	7.96e-02	1.49e-02	Zdhhc1

Pleiotropic Associations

Trait	Chi² ratio	# genes⁺	# genes⁺⁺	% genes⁺⁺	Corr P	Genes
BMI without tail	5.19	1	0	0	1e+00	Serbp1
Epididymis fat weight	3.94	1	0	0	1e+00	Zdhhc1
Left kidney weight	12.42	1	1	50	1e+00	Zdhhc1
Right kidney weight	10.82	2	1	50	1e+00	Serbp1 Zdhhc1
Tail length	2.86	1	0	0	1e+00	Serbp1
Length with tail	3.13	1	0	0	1e+00	Serbp1
Liver weight, left	7.79	1	0	0	1e+00	Serbp1
Parametrial fat weight	9.49	1	0	0	1e+00	Zdhhc1
Retroperitoneal fat weight	2.92	2	0	0	1e+00	Serbp1 Zdhhc1
Intraocular pressure	4.98	2	0	0	1e+00	Serbp1 Zdhhc1
Patch foraging indifference point AUC	10	2	0	0	1e+00	Serbp1 Zdhhc1
Patch foraging total patch changes 12 sec	3.95	1	0	0	1e+00	Zdhhc1
Patch foraging total patch changes 18 sec	7.52	2	0	0	1e+00	Serbp1 Zdhhc1
Patch foraging total patch changes 24 sec	6.8	1	0	0	1e+00	Zdhhc1
Patch foraging total patch changes 6 sec	5.84	2	0	0	1e+00	Serbp1 Zdhhc1
Patch foraging water rate 0 sec	6.51	1	0	0	1e+00	Serbp1
Patch foraging water rate 12 sec	4.1	1	0	0	1e+00	Serbp1
Patch foraging water rate 18 sec	5.76	2	0	0	1e+00	Serbp1 Zdhhc1
Patch foraging water rate 6 sec	6.12	1	0	0	1e+00	Zdhhc1
Locomotor activity	5.94	2	0	0	1e+00	Serbp1 Zdhhc1
Locomotor testing rearing	6.23	1	0	0	1e+00	Zdhhc1
Light reinforcement 1	9.14	2	0	0	1e+00	Serbp1 Zdhhc1
Light reinforcement 2	5.98	2	0	0	1e+00	Serbp1 Zdhhc1
Reaction time number correct	6.37	1	0	0	1e+00	Zdhhc1
Reaction time mean minus median AUC	6.75	1	0	0	1e+00	Zdhhc1
Reaction time trials correct on left	6.37	1	0	0	1e+00	Zdhhc1
Reaction time trials on left	6.86	1	0	0	1e+00	Zdhhc1
Reaction time mean	24.17	1	1	50	1e+00	Zdhhc1
Reaction time mean AUC	11.98	2	0	0	1e+00	Serbp1 Zdhhc1
Median of all reaction times	26.45	1	1	50	1e+00	Zdhhc1
Reaction time omissions	4.8	1	0	0	1e+00	Serbp1
Reaction time premature initiations	6.63	1	0	0	1e+00	Serbp1
Std. dev. reaction times	8.62	1	0	0	1e+00	Zdhhc1
Reaction time trials completed	6.86	1	0	0	1e+00	Zdhhc1
Reaction time trials AUC	6.44	1	0	0	1e+00	Zdhhc1
Social response proportion	10.93	1	0	0	1e+00	Zdhhc1
Social time	4.57	1	0	0	1e+00	Serbp1
Conditioned locomotion	5.5	1	0	0	1e+00	Zdhhc1
Conditioned locomotion	7.31	2	0	0	1e+00	Serbp1 Zdhhc1
Intermitt. access day 15 inactive lever presses	6.97	2	0	0	1e+00	Serbp1 Zdhhc1
Intermittent access day 1 total infusions	10.73	2	0	0	1e+00	Serbp1 Zdhhc1
Intermittent access day 15 total infusions	12.61	2	0	0	1e+00	Serbp1 Zdhhc1
Intermittent access terminal intake (last 3 days)	22.01	2	1	50	1e+00	Serbp1 Zdhhc1
Intermittent access total infusions	11.48	2	0	0	1e+00	Serbp1 Zdhhc1
Intermittent access standard deviation	5.46	1	0	0	1e+00	Serbp1
Post-drug Anxiety	8.64	1	0	0	1e+00	Zdhhc1
Lifetime Intake	11.68	2	0	0	1e+00	Serbp1 Zdhhc1
Incentive Sensitization - Responses	29.92	1	1	50	1e+00	Zdhhc1
Incentive Sensitization - Breakpoint	30.58	1	1	50	1e+00	Zdhhc1
Progressive ratio test 1 active lever presses	17.21	2	0	0	1e+00	Serbp1 Zdhhc1
Progressive ratio test 1 breakpoint	17.07	2	1	50	1e+00	Serbp1 Zdhhc1
Progressive ratio test 1 inactive lever presses	8.4	2	0	0	1e+00	Serbp1 Zdhhc1
Progressive ratio test 2 active lever presses	18.39	2	1	50	1e+00	Serbp1 Zdhhc1
Progressive ratio test 2 breakpoint	15.45	2	0	0	1e+00	Serbp1 Zdhhc1
Progressive ratio test 2 inactive lever presses	6.75	1	0	0	1e+00	Serbp1
Short access day 1 total inactive lever presses	51.32	1	1	50	1e+00	Serbp1
Short access day 10 total inactive lever presses	21.75	2	1	50	1e+00	Serbp1 Zdhhc1
Short access day 1 total infusions	18.97	2	0	0	1e+00	Serbp1 Zdhhc1
Short access day 10 total infusions	7.41	1	0	0	1e+00	Zdhhc1
Short access total infusions	8.98	2	0	0	1e+00	Serbp1 Zdhhc1
Short access day 1 locomotion	8.45	1	0	0	1e+00	Serbp1
Compulsive drug intake	12.43	1	0	0	1e+00	Serbp1
One hour access (shock baseline)	14.65	1	0	0	1e+00	Zdhhc1
Number of responses in last shaping day	10.31	2	0	0	1e+00	Serbp1 Zdhhc1
Locomotion velocity, session 7	6.12	1	0	0	1e+00	Serbp1
Bone surface	3.9	1	0	0	1e+00	Zdhhc1
Bone volume	4.11	1	0	0	1e+00	Zdhhc1
Bone: trabecular number	3.43	1	0	0	1e+00	Zdhhc1
Distance traveled before self-admin	50.41	1	1	50	1e+00	Zdhhc1
Delta time in closed arm before/after self-admin	10.9	1	0	0	1e+00	Serbp1
Delta time in open arm before/after self-admin	18.29	2	0	0	1e+00	Serbp1 Zdhhc1
Diff in mean of infusions in LGA sessions	18.85	1	0	0	1e+00	Serbp1
Extinction: sum of active levers before priming	6.15	1	0	0	1e+00	Zdhhc1
Active lever presses in extinction session 6	19.55	2	1	50	1e+00	Serbp1 Zdhhc1
Delta ambulatory time before/after self-admin	16.57	1	0	0	1e+00	Zdhhc1
Time in closed arm before self-admin	12.91	2	0	0	1e+00	Serbp1 Zdhhc1
Time in closed arm after self-admin	7.39	2	0	0	1e+00	Serbp1 Zdhhc1
Sum of active levers in priming session hrs 5-6	8.73	1	0	0	1e+00	Serbp1
Time to tail flick, vehicle, before self-admin	16.84	2	0	0	1e+00	Serbp1 Zdhhc1
Time to tail flick, vehicle, after self-admin	50.98	1	1	50	1e+00	Serbp1
Time to tail flick, test, before self-admin	5.82	1	0	0	1e+00	Serbp1
Time to tail flick, test, after self-admin	5.3	1	0	0	1e+00	Zdhhc1
Delta time to tail flick, vehicle, before/after SA	9.85	1	0	0	1e+00	Serbp1
Ambulatory time before self-admin	34.4	1	1	50	1e+00	Zdhhc1
Ambulatory time after self-admin	17.94	1	0	0	1e+00	Serbp1
Total heroin consumption	10.71	1	0	0	1e+00	Serbp1
Delay disc. indifference point, 2s delay	7.52	1	0	0	1e+00	Zdhhc1
Change in fecal boli incidents, locomotor task	13.85	1	0	0	1e+00	Serbp1
Time >=10cm from walls, locomotor time 1	16	1	0	0	1e+00	Zdhhc1
Rest time, locomotor task time 1	11.28	2	0	0	1e+00	Serbp1 Zdhhc1
Distance moved, locomotor task time 1	5.4	1	0	0	1e+00	Zdhhc1
Vertical activity count, locomotor time 1	8.46	2	0	0	1e+00	Serbp1 Zdhhc1
Time >=10cm from walls, locomotor time 2	5.83	1	0	0	1e+00	Zdhhc1
Rest time, locomotor task time 2	15.61	1	0	0	1e+00	Zdhhc1
Distance moved, locomotor task time 2	17.95	1	0	0	1e+00	Zdhhc1
Vertical activity count, locomotor time 2	9.06	2	0	0	1e+00	Serbp1 Zdhhc1
Seeking ratio, delayed vs. immediate footshock	5.96	1	0	0	1e+00	Serbp1
Locomotion in novel chamber post-restriction	18.24	1	0	0	1e+00	Serbp1
Progressive ratio	22.47	1	0	0	1e+00	Zdhhc1
Seeking ratio, punishment vs. effort	9.83	1	0	0	1e+00	Zdhhc1
Latency to leave start box in cocaine runway, F	9.76	1	0	0	1e+00	Zdhhc1
Latency to leave start box in cocaine runway, M	42.07	1	1	50	1e+00	Zdhhc1

Associations by panel

Tissue	RNA modality	# hits	Avg chisq
Adipose	alternative polyA	0	1.08
Adipose	alternative TSS	0	1.11
Adipose	gene expression	0	1.1
Adipose	isoform ratio	0	1.13
Adipose	intron excision ratio	0	1.09
Adipose	mRNA stability	0	1.12
BLA	alternative polyA	0	1.04
BLA	alternative TSS	0	1.11
BLA	gene expression	0	1.13
BLA	isoform ratio	0	1.12
BLA	intron excision ratio	0	1.06
BLA	mRNA stability	0	1.13
Brain	alternative polyA	0	1.1
Brain	alternative TSS	0	1.09
Brain	gene expression	0	1.1
Brain	isoform ratio	0	1.1
Brain	intron excision ratio	0	1.06
Brain	mRNA stability	0	1.11
Eye	alternative polyA	0	1.06
Eye	alternative TSS	0	1.08
Eye	gene expression	0	1.18
Eye	isoform ratio	0	1.09
Eye	intron excision ratio	0	1.05
Eye	mRNA stability	0	1.15
IL	alternative polyA	0	1.07
IL	alternative TSS	0	1.1
IL	gene expression	0	1.1
IL	isoform ratio	0	1.07
IL	intron excision ratio	0	0.98
IL	mRNA stability	0	1.15
LHb	alternative polyA	0	1.03
LHb	alternative TSS	0	1.14
LHb	gene expression	0	1.13
LHb	isoform ratio	0	1.05
LHb	intron excision ratio	0	1.04
LHb	mRNA stability	0	1.13
Liver	alternative polyA	0	1.08
Liver	alternative TSS	0	1.21
Liver	gene expression	0	1.13
Liver	isoform ratio	1	1.14
Liver	intron excision ratio	0	1.14
Liver	mRNA stability	0	1.14
NAcc	alternative polyA	0	1.11
NAcc	alternative TSS	0	1.11
NAcc	gene expression	0	1.11
NAcc	isoform ratio	0	1.11
NAcc	intron excision ratio	0	1.08
NAcc	mRNA stability	1	1.17
OFC	alternative polyA	0	1.08
OFC	alternative TSS	0	1.26
OFC	gene expression	0	1.09
OFC	isoform ratio	0	0.99
OFC	intron excision ratio	0	1.06
OFC	mRNA stability	0	1.14
PL	alternative polyA	0	1.09
PL	alternative TSS	0	1.08
PL	gene expression	0	1.1
PL	isoform ratio	0	1.13
PL	intron excision ratio	0	1.08
PL	mRNA stability	0	1.14
pVTA	alternative polyA	0	1.16
pVTA	alternative TSS	0	1.1
pVTA	gene expression	0	1.11
pVTA	isoform ratio	0	1.11
pVTA	intron excision ratio	0	1.08
pVTA	mRNA stability	0	1.2
RMTg	alternative polyA	0	1.11
RMTg	alternative TSS	0	1.44
RMTg	gene expression	0	1.09
RMTg	isoform ratio	0	1.09
RMTg	intron excision ratio	0	1.1
RMTg	mRNA stability	0	1.13