Total sessions with >9 infusions

Tags: Behavior · Cocaine · Short access

Project: p50_paul_meyer_2020

2 loci · 2 genes with independent associations · 2 total associated genes

Significant Loci

# Chr Start pos End pos # assoc genes # joint models Best TWAS P Best GWAS P Cond GWAS P Joint genes
1 chr4 95890735 97085238 1 1 2.90e-11 4.14e-01 1.23e-41 Serbp1
2 chr19 32676171 34074113 1 1 3.08e-13 7.96e-02 1.49e-02 Zdhhc1

Pleiotropic Associations

Trait Chi2 ratio # genes+ # genes++ % genes++ Corr Corr P Genes
BMI without tail 5.19 1 0 0 0 1e+00 Serbp1
Epididymis fat weight 3.94 1 0 0 0 1e+00 Zdhhc1
Left kidney weight 12.42 1 1 50 0 1e+00 Zdhhc1
Right kidney weight 10.82 2 1 50 0 1e+00 Serbp1 Zdhhc1
Tail length 2.86 1 0 0 0 1e+00 Serbp1
Length with tail 3.13 1 0 0 0 1e+00 Serbp1
Liver weight, left 7.79 1 0 0 0 1e+00 Serbp1
Parametrial fat weight 9.49 1 0 0 0 1e+00 Zdhhc1
Retroperitoneal fat weight 2.92 2 0 0 0 1e+00 Serbp1 Zdhhc1
Intraocular pressure 4.98 2 0 0 0 1e+00 Serbp1 Zdhhc1
Patch foraging indifference point AUC 10 2 0 0 0 1e+00 Serbp1 Zdhhc1
Patch foraging total patch changes 12 sec 3.95 1 0 0 0 1e+00 Zdhhc1
Patch foraging total patch changes 18 sec 7.52 2 0 0 0 1e+00 Serbp1 Zdhhc1
Patch foraging total patch changes 24 sec 6.8 1 0 0 0 1e+00 Zdhhc1
Patch foraging total patch changes 6 sec 5.84 2 0 0 0 1e+00 Serbp1 Zdhhc1
Patch foraging water rate 0 sec 6.51 1 0 0 0 1e+00 Serbp1
Patch foraging water rate 12 sec 4.1 1 0 0 0 1e+00 Serbp1
Patch foraging water rate 18 sec 5.76 2 0 0 0 1e+00 Serbp1 Zdhhc1
Patch foraging water rate 6 sec 6.12 1 0 0 0 1e+00 Zdhhc1
Locomotor activity 5.94 2 0 0 0 1e+00 Serbp1 Zdhhc1
Locomotor testing rearing 6.23 1 0 0 0 1e+00 Zdhhc1
Light reinforcement 1 9.14 2 0 0 0 1e+00 Serbp1 Zdhhc1
Light reinforcement 2 5.98 2 0 0 0 1e+00 Serbp1 Zdhhc1
Reaction time number correct 6.37 1 0 0 0 1e+00 Zdhhc1
Reaction time mean minus median AUC 6.75 1 0 0 0 1e+00 Zdhhc1
Reaction time trials correct on left 6.37 1 0 0 0 1e+00 Zdhhc1
Reaction time trials on left 6.86 1 0 0 0 1e+00 Zdhhc1
Reaction time mean 24.17 1 1 50 0 1e+00 Zdhhc1
Reaction time mean AUC 11.98 2 0 0 0 1e+00 Serbp1 Zdhhc1
Median of all reaction times 26.45 1 1 50 0 1e+00 Zdhhc1
Reaction time omissions 4.8 1 0 0 0 1e+00 Serbp1
Reaction time premature initiations 6.63 1 0 0 0 1e+00 Serbp1
Std. dev. reaction times 8.62 1 0 0 0 1e+00 Zdhhc1
Reaction time trials completed 6.86 1 0 0 0 1e+00 Zdhhc1
Reaction time trials AUC 6.44 1 0 0 0 1e+00 Zdhhc1
Social response proportion 10.93 1 0 0 0 1e+00 Zdhhc1
Social time 4.57 1 0 0 0 1e+00 Serbp1
Conditioned locomotion 5.5 1 0 0 0 1e+00 Zdhhc1
Conditioned locomotion 7.31 2 0 0 0 1e+00 Serbp1 Zdhhc1
Intermitt. access day 15 inactive lever presses 6.97 2 0 0 0 1e+00 Serbp1 Zdhhc1
Intermittent access day 1 total infusions 10.73 2 0 0 0 1e+00 Serbp1 Zdhhc1
Intermittent access day 15 total infusions 12.61 2 0 0 0 1e+00 Serbp1 Zdhhc1
Intermittent access terminal intake (last 3 days) 22.01 2 1 50 0 1e+00 Serbp1 Zdhhc1
Intermittent access total infusions 11.48 2 0 0 0 1e+00 Serbp1 Zdhhc1
Intermittent access standard deviation 5.46 1 0 0 0 1e+00 Serbp1
Post-drug Anxiety 8.64 1 0 0 0 1e+00 Zdhhc1
Lifetime Intake 11.68 2 0 0 0 1e+00 Serbp1 Zdhhc1
Incentive Sensitization - Responses 29.92 1 1 50 0 1e+00 Zdhhc1
Incentive Sensitization - Breakpoint 30.58 1 1 50 0 1e+00 Zdhhc1
Progressive ratio test 1 active lever presses 17.21 2 0 0 0 1e+00 Serbp1 Zdhhc1
Progressive ratio test 1 breakpoint 17.07 2 1 50 0 1e+00 Serbp1 Zdhhc1
Progressive ratio test 1 inactive lever presses 8.4 2 0 0 0 1e+00 Serbp1 Zdhhc1
Progressive ratio test 2 active lever presses 18.39 2 1 50 0 1e+00 Serbp1 Zdhhc1
Progressive ratio test 2 breakpoint 15.45 2 0 0 0 1e+00 Serbp1 Zdhhc1
Progressive ratio test 2 inactive lever presses 6.75 1 0 0 0 1e+00 Serbp1
Short access day 1 total inactive lever presses 51.32 1 1 50 0 1e+00 Serbp1
Short access day 10 total inactive lever presses 21.75 2 1 50 0 1e+00 Serbp1 Zdhhc1
Short access day 1 total infusions 18.97 2 0 0 0 1e+00 Serbp1 Zdhhc1
Short access day 10 total infusions 7.41 1 0 0 0 1e+00 Zdhhc1
Short access total infusions 8.98 2 0 0 0 1e+00 Serbp1 Zdhhc1
Short access day 1 locomotion 8.45 1 0 0 0 1e+00 Serbp1
Compulsive drug intake 12.43 1 0 0 0 1e+00 Serbp1
One hour access (shock baseline) 14.65 1 0 0 0 1e+00 Zdhhc1
Number of responses in last shaping day 10.31 2 0 0 0 1e+00 Serbp1 Zdhhc1
Locomotion velocity, session 7 6.12 1 0 0 0 1e+00 Serbp1
Bone surface 3.9 1 0 0 0 1e+00 Zdhhc1
Bone volume 4.11 1 0 0 0 1e+00 Zdhhc1
Bone: trabecular number 3.43 1 0 0 0 1e+00 Zdhhc1
Distance traveled before self-admin 50.41 1 1 50 0 1e+00 Zdhhc1
Delta time in closed arm before/after self-admin 10.9 1 0 0 0 1e+00 Serbp1
Delta time in open arm before/after self-admin 18.29 2 0 0 0 1e+00 Serbp1 Zdhhc1
Diff in mean of infusions in LGA sessions 18.85 1 0 0 0 1e+00 Serbp1
Extinction: sum of active levers before priming 6.15 1 0 0 0 1e+00 Zdhhc1
Active lever presses in extinction session 6 19.55 2 1 50 0 1e+00 Serbp1 Zdhhc1
Delta ambulatory time before/after self-admin 16.57 1 0 0 0 1e+00 Zdhhc1
Time in closed arm before self-admin 12.91 2 0 0 0 1e+00 Serbp1 Zdhhc1
Time in closed arm after self-admin 7.39 2 0 0 0 1e+00 Serbp1 Zdhhc1
Sum of active levers in priming session hrs 5-6 8.73 1 0 0 0 1e+00 Serbp1
Time to tail flick, vehicle, before self-admin 16.84 2 0 0 0 1e+00 Serbp1 Zdhhc1
Time to tail flick, vehicle, after self-admin 50.98 1 1 50 0 1e+00 Serbp1
Time to tail flick, test, before self-admin 5.82 1 0 0 0 1e+00 Serbp1
Time to tail flick, test, after self-admin 5.3 1 0 0 0 1e+00 Zdhhc1
Delta time to tail flick, vehicle, before/after SA 9.85 1 0 0 0 1e+00 Serbp1
Ambulatory time before self-admin 34.4 1 1 50 0 1e+00 Zdhhc1
Ambulatory time after self-admin 17.94 1 0 0 0 1e+00 Serbp1
Total heroin consumption 10.71 1 0 0 0 1e+00 Serbp1
Delay disc. indifference point, 2s delay 7.52 1 0 0 0 1e+00 Zdhhc1
Change in fecal boli incidents, locomotor task 13.85 1 0 0 0 1e+00 Serbp1
Time >=10cm from walls, locomotor time 1 16 1 0 0 0 1e+00 Zdhhc1
Rest time, locomotor task time 1 11.28 2 0 0 0 1e+00 Serbp1 Zdhhc1
Distance moved, locomotor task time 1 5.4 1 0 0 0 1e+00 Zdhhc1
Vertical activity count, locomotor time 1 8.46 2 0 0 0 1e+00 Serbp1 Zdhhc1
Time >=10cm from walls, locomotor time 2 5.83 1 0 0 0 1e+00 Zdhhc1
Rest time, locomotor task time 2 15.61 1 0 0 0 1e+00 Zdhhc1
Distance moved, locomotor task time 2 17.95 1 0 0 0 1e+00 Zdhhc1
Vertical activity count, locomotor time 2 9.06 2 0 0 0 1e+00 Serbp1 Zdhhc1
Seeking ratio, delayed vs. immediate footshock 5.96 1 0 0 0 1e+00 Serbp1
Locomotion in novel chamber post-restriction 18.24 1 0 0 0 1e+00 Serbp1
Progressive ratio 22.47 1 0 0 0 1e+00 Zdhhc1
Seeking ratio, punishment vs. effort 9.83 1 0 0 0 1e+00 Zdhhc1
Latency to leave start box in cocaine runway, F 9.76 1 0 0 0 1e+00 Zdhhc1
Latency to leave start box in cocaine runway, M 42.07 1 1 50 0 1e+00 Zdhhc1

Associations by panel

Tissue RNA modality # hits % hits/tests Avg chisq
Adipose alternative polyA 0 0 1.08
Adipose alternative TSS 0 0 1.11
Adipose gene expression 0 0 1.1
Adipose isoform ratio 0 0 1.13
Adipose intron excision ratio 0 0 1.09
Adipose mRNA stability 0 0 1.12
BLA alternative polyA 0 0 1.04
BLA alternative TSS 0 0 1.11
BLA gene expression 0 0 1.13
BLA isoform ratio 0 0 1.12
BLA intron excision ratio 0 0 1.06
BLA mRNA stability 0 0 1.13
Brain alternative polyA 0 0 1.1
Brain alternative TSS 0 0 1.09
Brain gene expression 0 0 1.1
Brain isoform ratio 0 0 1.1
Brain intron excision ratio 0 0 1.06
Brain mRNA stability 0 0 1.11
Eye alternative polyA 0 0 1.06
Eye alternative TSS 0 0 1.08
Eye gene expression 0 0 1.18
Eye isoform ratio 0 0 1.09
Eye intron excision ratio 0 0 1.05
Eye mRNA stability 0 0 1.15
IL alternative polyA 0 0 1.07
IL alternative TSS 0 0 1.1
IL gene expression 0 0 1.1
IL isoform ratio 0 0 1.07
IL intron excision ratio 0 0 0.98
IL mRNA stability 0 0 1.15
LHb alternative polyA 0 0 1.03
LHb alternative TSS 0 0 1.14
LHb gene expression 0 0 1.13
LHb isoform ratio 0 0 1.05
LHb intron excision ratio 0 0 1.04
LHb mRNA stability 0 0 1.13
Liver alternative polyA 0 0 1.08
Liver alternative TSS 0 0 1.21
Liver gene expression 0 0 1.13
Liver isoform ratio 1 0 1.14
Liver intron excision ratio 0 0 1.14
Liver mRNA stability 0 0 1.14
NAcc alternative polyA 0 0 1.11
NAcc alternative TSS 0 0 1.11
NAcc gene expression 0 0 1.11
NAcc isoform ratio 0 0 1.11
NAcc intron excision ratio 0 0 1.08
NAcc mRNA stability 1 0 1.17
OFC alternative polyA 0 0 1.08
OFC alternative TSS 0 0 1.26
OFC gene expression 0 0 1.09
OFC isoform ratio 0 0 0.99
OFC intron excision ratio 0 0 1.06
OFC mRNA stability 0 0 1.14
PL alternative polyA 0 0 1.09
PL alternative TSS 0 0 1.08
PL gene expression 0 0 1.1
PL isoform ratio 0 0 1.13
PL intron excision ratio 0 0 1.08
PL mRNA stability 0 0 1.14
pVTA alternative polyA 0 0 1.16
pVTA alternative TSS 0 0 1.1
pVTA gene expression 0 0 1.11
pVTA isoform ratio 0 0 1.11
pVTA intron excision ratio 0 0 1.08
pVTA mRNA stability 0 0 1.2
RMTg alternative polyA 0 0 1.11
RMTg alternative TSS 0 0 1.44
RMTg gene expression 0 0 1.09
RMTg isoform ratio 0 0 1.09
RMTg intron excision ratio 0 0 1.1
RMTg mRNA stability 0 0 1.13