Hub : Traits

Progressive ratio test 1 active lever presses

Tags: Behavior · Motivation · Progressive ratio

Project: p50_paul_meyer_2020

2 significantly associated models · 2 unique genes

Significant Loci

# chr p0 p1 # assoc genes # joint models best TWAS P best SNP P cond SNP P % var exp joint genes
1 11 39057816 40174684 1 1 1.9e-07 0.00079 1.00 100 Epha6
2 16 44034037 45431861 1 1 1.8e-07 0.00504 0.39 91 Trappc11

p0: physical position of the start of the locus. p1: physical position of the end of the locus. # joint models: number of models selected by step-wise conditional analysis.

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
BMI with tail 4.0 1 0 0 0 1 Trappc11
BMI without tail 4.3 1 0 0 0 1 Trappc11
Epididymis fat weight 2.6 1 0 0 0 1 Trappc11
Parametrial fat weight 14.7 1 1 50 0 1 Epha6
Tibia length 1.8 1 0 0 0 1 Epha6
Food consumed during 24 hour testing period 5.7 1 0 0 0 1 Epha6
Times rat made contact with spout 14.8 1 0 0 0 1 Epha6
Water consumed over 24 hours 16.4 1 0 0 0 1 Epha6
Delay discounting total patch changes 12 sec 8.8 1 0 0 0 1 Epha6
Delay discounting total patch changes 18 sec 10.0 1 0 0 0 1 Epha6
Delay discounting total patch changes 6 sec 9.5 1 0 0 0 1 Epha6
Delay discounting water rate 18 sec 11.1 1 0 0 0 1 Epha6
Delay discounting water rate 24 sec 4.3 1 0 0 0 1 Trappc11
Locomotor activity 5.8 1 0 0 0 1 Epha6
Locomotor testing distance 7.0 1 0 0 0 1 Epha6
Light reinforcement 2 4.0 1 0 0 0 1 Epha6
Reaction time premature initiation rate 6.8 2 0 0 0 1 Trappc11 Epha6
Reaction time premature initiations 5.8 1 0 0 0 1 Epha6
Social response proportion 11.0 1 0 0 0 1 Trappc11
Conditioned locomotion 16.0 1 0 0 0 1 Epha6
Cocaine response before conditioning 7.1 1 0 0 0 1 Epha6
Condit. Reinf. lever presses 5.6 1 0 0 0 1 Epha6
Pavlov. Cond. lever latency 4.4 1 0 0 0 1 Epha6
Pavlov. Cond. lever contacts 4.2 1 0 0 0 1 Epha6
Pavlov. Cond. magazine entry number 4.3 1 0 0 0 1 Epha6
Conditioned reinforcement - actives 20.7 1 0 0 0 1 Epha6
Conditioned reinforcement - inactives 22.3 1 0 0 0 1 Epha6
Conditioned locomotion 9.7 1 0 0 0 1 Trappc11
Intermittent access day 1 total infusions 10.5 2 0 0 0 1 Trappc11 Epha6
Intermittent access day 15 total infusions 9.4 2 0 0 0 1 Trappc11 Epha6
Intermittent access terminal intake (last 3 days) 12.8 2 0 0 0 1 Trappc11 Epha6
Intermittent access total infusions 14.5 2 0 0 0 1 Trappc11 Epha6
Intermittent access day 1 locomotion 12.2 1 0 0 0 1 Trappc11
Intermittent access total locomotion 10.9 1 0 0 0 1 Trappc11
Cocaine induced anxiety 13.1 1 0 0 0 1 Epha6
Baseline Anxiety 17.8 1 0 0 0 1 Epha6
Lifetime Intake 19.7 2 1 50 0 1 Trappc11 Epha6
Incentive Sensitization - Responses 10.0 2 0 0 0 1 Trappc11 Epha6
Incentive Sensitization - Breakpoint 8.8 2 0 0 0 1 Trappc11 Epha6
Progressive ratio test 1 breakpoint 28.0 2 1 50 0 1 Trappc11 Epha6
Progressive ratio test 1 inactive lever presses 8.6 2 0 0 0 1 Trappc11 Epha6
Progressive ratio test 2 active lever presses 26.2 2 1 50 0 1 Trappc11 Epha6
Progressive ratio test 2 breakpoint 23.5 2 1 50 0 1 Trappc11 Epha6
Progressive ratio test 2 inactive lever presses 19.3 2 1 50 0 1 Trappc11 Epha6
Total sessions with >9 infusions 13.1 1 0 0 0 1 Epha6
Short access day 1 total inactive lever presses 9.2 2 0 0 0 1 Trappc11 Epha6
Short access day 1 total infusions 19.6 2 1 50 0 1 Trappc11 Epha6
Short access total infusions 21.6 2 1 50 0 1 Trappc11 Epha6
Short access day 1 locomotion 9.7 1 0 0 0 1 Trappc11
Short access total locomotion 11.1 1 0 0 0 1 Trappc11
One hour access (0.3 mA shock) 23.3 2 1 50 0 1 Trappc11 Epha6
One hour access (shock baseline) 18.9 2 0 0 0 1 Trappc11 Epha6
Number of responses in last shaping day 10.9 1 0 0 0 1 Trappc11
Locomotion distance, session 1 8.8 1 0 0 0 1 Epha6
Stereotopy head waving bouts, day 3 5.1 1 0 0 0 1 Epha6
Locomotion velocity, session 7 5.9 1 0 0 0 1 Epha6
Locomotion distance, session 7 13.3 1 0 0 0 1 Epha6
Stereotopy head waving bouts, day 7 4.8 1 0 0 0 1 Trappc11
Stereotopy head waving duration, day 7 8.4 1 0 0 0 1 Trappc11
Locomotion distance, session 8 4.5 1 0 0 0 1 Epha6
Degree of sensitization stereotypy 6.6 1 0 0 0 1 Trappc11
Condit. Reinf. active minus inactive responses 4.8 1 0 0 0 1 Epha6
Condit. Reinf. active-inactive response ratio 7.4 1 0 0 0 1 Epha6
Condit. Reinf. active responses 5.2 1 0 0 0 1 Epha6
Incentive salience index mean 5.0 1 0 0 0 1 Epha6
Condit. Reinf. lever presses 5.4 1 0 0 0 1 Epha6
Time in familiar zone, hab. session 1 8.7 1 0 0 0 1 Epha6
Time in novel zone, hab. session 1 6.7 1 0 0 0 1 Epha6
Locomotion velocity, hab. session 1 4.0 1 0 0 0 1 Epha6
Time in familiar zone, hab. session 2 22.6 1 0 0 0 1 Epha6
Time in novel zone, hab. session 2 20.3 1 0 0 0 1 Epha6
Total zone transitions, hab. session 2 4.8 1 0 0 0 1 Epha6
Total locomotion distance, hab. session 2 7.5 1 0 0 0 1 Epha6
Locomotion velocity, hab. session 2 7.2 1 0 0 0 1 Epha6
Novelty place preference 5.5 1 0 0 0 1 Epha6
Total zone transitions, NPP test 3.7 1 0 0 0 1 Epha6
Pavlov. Cond. lever latency 9.6 1 0 0 0 1 Epha6
Pavlov. Cond. magazine entry latency 27.7 1 1 50 0 1 Epha6
Pavlov. Cond. change in total contacts 6.4 1 0 0 0 1 Epha6
Pavlov. Cond. index score 19.3 1 0 0 0 1 Epha6
Pavlov. Cond. latency score 17.9 1 0 0 0 1 Epha6
Pavlov. Cond. lever contacts 15.4 1 0 0 0 1 Epha6
Pavlov. Cond. magazine entry number 10.9 1 0 0 0 1 Epha6
Pavlov. Cond. lever-magazine prob. diff. 18.3 1 0 0 0 1 Epha6
Pavlov. Cond. response bias 19.5 1 0 0 0 1 Epha6
Bone surface 4.2 1 0 0 0 1 Epha6
Bone: connectivity density 4.6 1 0 0 0 1 Epha6
Bone: cortical thickness 8.9 2 0 0 0 1 Trappc11 Epha6
Bone: elastic displacement 6.6 1 0 0 0 1 Trappc11
Bone: elastic work 6.3 1 0 0 0 1 Trappc11
Bone: endosteal estimation 3.3 1 0 0 0 1 Epha6
Bone: marrow area 3.0 1 0 0 0 1 Epha6
Bone: maximum diameter 4.8 1 0 0 0 1 Epha6
Bone: periosteal estimation 2.7 1 0 0 0 1 Epha6
Bone: periosteal perimeter 3.1 1 0 0 0 1 Epha6
Bone: stiffness 6.1 1 0 0 0 1 Epha6
Distance traveled after self-admin 12.1 1 0 0 0 1 Trappc11
Time to tail flick, test, before self-admin 5.5 1 0 0 0 1 Epha6
Delta time to tail flick, vehicle, before/after SA 7.9 1 0 0 0 1 Epha6
Ambulatory time after self-admin 11.2 1 0 0 0 1 Trappc11
Total heroin consumption 4.8 1 0 0 0 1 Epha6
Area under the delay curve 6.5 1 0 0 0 1 Epha6
Delay disc. indifference point, 0s delay 11.2 1 0 0 0 1 Epha6
Delay disc. indifference point, 4s delay 10.2 1 0 0 0 1 Epha6
Delay disc. indifference point, 8s delay 7.9 1 0 0 0 1 Epha6
Delay discount exponential model param 6.6 1 0 0 0 1 Epha6
Delay discount hyperbolic model param 6.7 1 0 0 0 1 Epha6
Vertical activity count, locomotor time 1 7.2 1 0 0 0 1 Epha6
Time >=10cm from walls, locomotor time 2 9.3 1 0 0 0 1 Trappc11
Seeking ratio, delayed vs. immediate footshock 10.9 1 0 0 0 1 Epha6
Locomotion in novel chamber post-restriction 15.1 1 0 0 0 1 Epha6
Latency to leave start box in cocaine runway 6.8 1 0 0 0 1 Epha6
Na content in liver 11.0 1 0 0 0 1 Epha6
Se content in liver 9.1 1 0 0 0 1 Epha6

chisq ratio: Average Chi2 statistic for the selected genes in the secondary trait, divided by the average statistic for all genes in the secondary trait. # genes+: Shared significant genes at Bonferroni correction. # genes++: Shared significant genes at transcriptome-wide significance. % genes++: Number of [++] genes as a percentage of primary trait’s total joint genes. corr: Correlation of effect sizes across the [+] genes.

Associations by panel

tissue modality # hits % hits/tests avg chisq
Adipose alternative polyA 0 0.000 1.02
Adipose alternative TSS 0 0.000 1.12
Adipose gene expression 0 0.000 1.04
Adipose isoform ratio 0 0.000 1.03
Adipose intron excision ratio 0 0.000 1.00
Adipose mRNA stability 0 0.000 1.05
BLA alternative polyA 0 0.000 1.10
BLA alternative TSS 0 0.000 0.96
BLA gene expression 0 0.000 1.03
BLA isoform ratio 0 0.000 0.96
BLA intron excision ratio 0 0.000 0.98
BLA mRNA stability 0 0.000 1.08
Brain alternative polyA 0 0.000 1.04
Brain alternative TSS 0 0.000 0.99
Brain gene expression 0 0.000 1.04
Brain isoform ratio 0 0.000 1.03
Brain intron excision ratio 0 0.000 0.99
Brain mRNA stability 0 0.000 1.04
Eye alternative polyA 0 0.000 1.51
Eye alternative TSS 0 0.000 1.13
Eye gene expression 0 0.000 1.10
Eye isoform ratio 0 0.000 1.13
Eye intron excision ratio 0 0.000 1.04
Eye mRNA stability 0 0.000 1.16
IL alternative polyA 0 0.000 1.05
IL alternative TSS 0 0.000 1.13
IL gene expression 0 0.000 1.03
IL isoform ratio 0 0.000 1.03
IL intron excision ratio 0 0.000 1.04
IL mRNA stability 0 0.000 1.14
LHb alternative polyA 0 0.000 1.11
LHb alternative TSS 0 0.000 0.96
LHb gene expression 0 0.000 1.07
LHb isoform ratio 0 0.000 1.05
LHb intron excision ratio 0 0.000 0.96
LHb mRNA stability 0 0.000 1.10
Liver alternative polyA 0 0.000 0.98
Liver alternative TSS 0 0.000 1.05
Liver gene expression 0 0.000 1.03
Liver isoform ratio 0 0.000 1.06
Liver intron excision ratio 0 0.000 1.06
Liver mRNA stability 0 0.000 1.07
NAcc alternative polyA 0 0.000 1.02
NAcc alternative TSS 0 0.000 1.09
NAcc gene expression 1 0.016 1.03
NAcc isoform ratio 0 0.000 1.04
NAcc intron excision ratio 0 0.000 0.99
NAcc mRNA stability 0 0.000 1.06
OFC alternative polyA 0 0.000 1.22
OFC alternative TSS 0 0.000 0.95
OFC gene expression 0 0.000 1.06
OFC isoform ratio 0 0.000 1.05
OFC intron excision ratio 0 0.000 0.99
OFC mRNA stability 0 0.000 1.10
PL alternative polyA 0 0.000 1.08
PL alternative TSS 1 0.085 1.14
PL gene expression 0 0.000 1.03
PL isoform ratio 0 0.000 1.04
PL intron excision ratio 0 0.000 0.96
PL mRNA stability 0 0.000 1.08

avg chisq: Average Chi2 (squared Z-score) across all models in this panel for this trait.