Emsy

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Brain	gene expression	Emsy	0.05	0.03	2.8e-04	0.02	0.04	0.04	0.04	2.4e-03	9.6e-05	1.3e-04	2.0e-04
2	Eye	intron excision ratio	chr1_162350411_162353811	0.42	0.24	6.4e-03	0.07	0.06	0.03	0.09	2.9e-02	4.1e-02	1.0e-01	1.5e-02
3	NAcc	intron excision ratio	chr1_162305509_162306332	0.02	0.01	8.2e-03	0.02	0.01	0.01	0.01	1.4e-03	4.2e-03	4.4e-03	2.8e-03
4	PL	gene expression	Emsy	0.04	0.03	7.8e-04	0.02	0.03	0.02	0.03	4.1e-03	4.5e-04	3.6e-03	3.5e-04
5	Brain	intron excision ratio	chr1_162346755_162350236	0.05	0.03	1.0e-03	0.02	0.02	0.01	0.02	2.4e-03	6.3e-03	3.2e-02	7.9e-03
6	Adipose	gene expression	Emsy	0.42	0.12	0.0e+00	0.35	0.35	0.35	0.35	8.5e-41	9.0e-40	3.5e-40	1.1e-40
7	Adipose	intron excision ratio	chr1_162363010_162364604	0.1	0.06	5.4e-10	0.07	0.06	0.05	0.07	3.7e-08	2.9e-07	1.4e-06	8.5e-08
8	Adipose	mRNA stability	Emsy	0.05	0.03	1.8e-04	0	0.01	0.01	0	1.6e-01	3.1e-02	2.1e-02	1.3e-01

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6	7	8
Bone: apparent density	0.1	0.1	0.4	0.3	0.6	0.4	0.3	-0.3	-0.0	0.5	-0.3
Area under the delay curve	0.1	0.2	0.4	-0.3	-0.2	-0.4	-0.2	0.7	0.3	-0.5	-0.3
BMI with tail	1.3	4.4	9.5	0.9	-0.4	1.9	2.0	-2.6	-2.6	2.0	3.1
BMI without tail	2.7	8.2	15.7	0.5	-1.3	2.3	2.2	-3.7	-3.8	3.2	4.0
Body weight	1.7	7.6	14.6	0.7	-1.1	2.1	2.1	-3.8	-3.7	2.7	3.8
Weight adjusted by age	0.6	0.9	1.8	-0.1	-0.7	0.4	0.4	-1.2	-1.4	1.1	1.4
Bone surface	0.7	1.3	2.3	-1.4	-1.4	-0.8	-1.0	-1.2	-1.0	1.5	0.3
Bone volume	0.5	0.9	2.3	-0.6	-0.9	0.0	-0.2	-1.4	-1.2	1.5	0.8
Breakpoint value in progressive ratio session	0.8	0.9	1.8	0.8	1.2	0.3	0.4	1.2	1.1	-1.3	-0.9
Number of licking bursts	1.7	2.7	6.7	2.6	2.1	2.4	2.1	-0.5	-0.3	-0.6	0.4
Context. condit. distance diff. score	1.2	1.4	4.3	-2.1	-1.3	-1.7	-1.4	0.0	0.1	0.2	-0.7
Locomotion velocity, session 1	0.8	0.8	2.4	0.4	0.6	-0.3	-0.1	1.2	1.2	-1.5	-0.9
Locomotion distance, session 1	0.7	0.8	1.5	-0.9	-0.5	-1.2	-1.0	0.8	0.7	-1.2	-0.6
Locomotion velocity, session 2	0.0	0.1	0.2	-0.0	-0.4	0.0	0.0	-0.1	-0.4	-0.1	0.3
Locomotion distance, session 2	0.1	0.2	0.5	-0.5	-0.6	-0.4	-0.4	0.0	-0.2	-0.7	0.1
Locomotion velocity, session 3	0.2	0.2	0.5	-0.7	-0.3	-0.6	-0.3	0.0	0.1	-0.7	-0.2
Locomotion distance, session 3	0.9	1.0	2.3	-1.1	-0.5	-1.3	-0.9	0.8	0.7	-1.5	-0.6
Stereotopy head waving bouts, day 3	0.3	0.4	0.9	0.9	0.4	0.8	0.9	-0.3	-0.2	0.5	0.6
Stereotopy head waving duration, day 3	0.1	0.2	0.4	-0.6	-0.6	-0.5	-0.5	-0.1	0.0	0.3	-0.2
Locomotion velocity, session 7	0.2	0.2	0.7	0.4	0.8	0.4	0.7	-0.0	0.1	-0.6	-0.1
Locomotion distance, session 7	0.2	0.2	0.5	0.2	0.2	0.5	0.5	-0.7	-0.6	-0.2	0.4
Stereotopy head waving bouts, day 7	1.3	1.4	3.4	-1.6	-1.0	-1.8	-1.6	0.8	0.8	-0.2	-0.9
Stereotopy head waving duration, day 7	1.2	1.5	3.3	-1.8	-1.5	-1.7	-1.7	0.0	0.0	0.5	-0.5
Locomotion velocity, session 8	1.0	1.2	2.4	-1.5	-1.2	-1.6	-1.5	0.1	0.4	0.1	-0.8
Locomotion distance, session 8	0.9	1.3	3.4	-1.8	-1.4	-1.7	-1.4	0.1	0.1	-0.3	-0.5
Degree of sensitization distance	1.6	1.7	3.0	0.8	-0.1	1.3	1.0	-1.7	-1.6	1.7	1.2
Degree of sensitization stereotypy	2.9	3.1	7.2	-2.3	-1.6	-2.7	-2.5	1.1	0.9	-0.4	-1.3
Conditioned locomotion	0.2	0.3	0.9	0.0	0.2	-0.2	-0.3	0.7	0.7	-1.0	-0.4
Cocaine response after cond. corrected	0.6	0.7	1.9	1.4	1.0	1.1	1.1	-0.2	-0.2	-0.4	0.4
Cocaine response after cond. not corrected	0.2	0.2	0.4	0.6	0.6	0.2	0.3	0.3	0.3	-0.6	-0.3
Cocaine response before conditioning	1.2	1.5	2.7	-1.4	-0.7	-1.6	-1.5	1.1	1.1	-0.3	-1.4
Saline control response	1.0	1.4	3.1	-1.4	-1.8	-1.1	-1.5	-1.0	-1.0	0.6	0.2
Bone: connectivity density	0.2	0.3	1.1	-0.4	0.2	-0.4	-0.5	0.4	0.5	0.3	-1.0
Bone: cortical apparent density	0.6	0.9	2.4	1.5	1.2	1.2	1.3	0.1	0.1	-0.0	0.1
Bone: cortical area	0.8	1.3	2.9	-0.4	-0.8	0.2	-0.0	-1.7	-1.6	1.7	1.1
Bone: cortical porosity	1.1	1.1	1.8	-1.1	-0.4	-1.3	-1.3	1.0	1.0	-1.1	-1.2
Bone: cortical porosity	0.9	1.0	1.5	-1.0	-0.4	-1.2	-1.2	1.0	1.0	-1.1	-1.0
Bone: cortical thickness	0.2	0.3	0.7	0.7	0.8	0.7	0.7	-0.4	-0.3	0.3	0.1
Bone: cortical thickness	0.0	0.0	0.1	-0.3	-0.3	-0.1	-0.2	-0.1	-0.2	-0.1	-0.1
Bone: cortical tissue density	0.6	0.8	2.3	1.5	1.2	1.1	1.2	0.2	0.3	-0.2	0.0
Condit. Reinf. active minus inactive responses	1.0	1.2	2.8	0.1	-0.3	0.5	0.8	-1.7	-1.5	1.2	1.3
Condit. Reinf. active-inactive response ratio	1.1	1.2	2.8	-0.4	-0.7	0.2	0.3	-1.7	-1.5	1.6	1.1
Condit. Reinf. active responses	0.6	0.8	1.9	0.4	0.2	0.6	0.9	-1.4	-1.2	0.6	1.1
Condit. Reinf. inactive responses	0.1	0.2	0.5	0.5	0.5	0.3	0.5	-0.2	-0.0	-0.7	0.2
Incentive salience index mean	0.8	0.9	2.2	0.1	-0.2	0.6	0.8	-1.5	-1.3	1.0	1.3
Condit. Reinf. lever presses	0.1	0.1	0.3	-0.0	0.0	0.3	0.3	-0.4	-0.3	0.2	0.6
Condit. Reinf. active minus inactive responses	3.9	5.0	10.4	-2.9	-3.2	-2.3	-2.2	-2.1	-2.0	1.0	1.0
Condit. Reinf. active-inactive response ratio	0.5	0.6	1.2	-1.0	-1.1	-0.7	-0.5	-0.8	-0.9	0.0	0.6
Condit. Reinf. active responses	5.9	8.2	17.3	-3.5	-4.2	-2.7	-2.7	-2.8	-2.7	2.0	1.6
Condit. Reinf. inactive responses	3.8	4.9	10.5	-2.4	-3.2	-1.9	-2.0	-2.2	-2.0	2.1	1.4
Condit. Reinf. lever presses	10.9	15.1	31.8	-5.6	-5.6	-4.9	-4.9	-1.9	-1.7	1.7	0.2
Condit. Reinf. lever reinforcers received	6.3	8.8	18.6	-3.8	-4.3	-3.0	-2.9	-2.7	-2.6	1.8	1.5
Conditioned reinforcement - actives	0.6	1.0	2.2	-1.5	-1.1	-1.5	-1.4	0.2	0.4	-0.2	-0.7
Conditioned reinforcement - inactives	0.6	0.8	1.8	0.3	0.8	-0.3	-0.4	1.3	1.3	-0.8	-1.3
Conditioned locomotion	2.0	2.6	5.1	-1.8	-1.1	-2.1	-2.2	1.2	1.1	-1.4	-1.5
Patch foraging indifference point 0 sec	2.5	4.7	10.8	-3.3	-2.9	-2.7	-2.9	-0.9	-0.9	1.1	-0.2
Patch foraging indifference point AUC	0.3	0.4	1.1	-0.1	-0.5	0.1	0.1	-0.8	-0.8	1.0	0.8
Delay disc. indifference point, 0s delay	0.5	0.6	1.5	-1.0	-1.2	-1.0	-0.7	-0.5	-0.7	0.1	0.5
Delay disc. indifference point, 16s delay	0.3	0.4	0.8	0.1	0.4	-0.3	0.1	0.9	0.8	-0.7	-0.8
Delay disc. indifference point, 2s delay	0.7	0.8	1.7	-1.3	-1.2	-1.2	-1.2	0.2	-0.1	-0.4	-0.3
Delay disc. indifference point, 24s delay	0.6	0.7	1.5	1.2	1.1	1.2	1.1	0.5	0.4	0.0	0.1
Delay disc. indifference point, 4s delay	0.6	0.6	1.7	-0.6	-1.3	-0.4	-0.3	-0.6	-1.0	0.0	1.0
Delay disc. indifference point, 8s delay	0.2	0.2	0.4	-0.6	-0.3	-0.6	-0.6	0.5	0.2	-0.1	-0.4
Indifference point function ln k	1.0	1.8	3.0	-1.7	-0.9	-1.7	-1.7	1.0	1.0	-1.2	-1.2
Indifference point function log k	1.0	1.8	3.0	-1.7	-0.9	-1.7	-1.7	1.0	1.0	-1.2	-1.2
Patch foraging total patch changes 0 sec	2.2	4.1	9.2	-3.0	-2.7	-2.5	-2.8	-0.8	-0.8	0.9	-0.2
Patch foraging total patch changes 12 sec	1.4	1.8	3.8	-1.2	-1.6	-0.5	-0.8	-1.5	-1.5	2.0	1.1
Patch foraging total patch changes 18 sec	1.9	2.8	5.1	-1.6	-2.2	-0.8	-1.0	-1.9	-1.9	2.2	1.3
Patch foraging total patch changes 24 sec	0.5	0.9	2.1	-0.7	-1.1	-0.3	-0.3	-1.3	-1.5	0.7	1.0
Patch foraging total patch changes 6 sec	1.0	1.5	3.3	-1.8	-1.2	-1.8	-1.8	-0.3	-0.1	0.5	-0.6
Patch foraging time to switch 0 sec	1.7	3.4	8.1	2.7	2.9	1.9	2.0	1.2	1.1	-1.2	-0.5
Patch foraging water rate 0 sec	1.5	3.1	6.8	-2.6	-2.6	-2.0	-2.1	-1.1	-1.0	0.7	0.3
Patch foraging water rate 12 sec	0.7	1.5	3.8	-1.9	-1.9	-1.4	-1.6	-0.4	-0.3	0.2	-0.0
Patch foraging water rate 18 sec	0.3	0.5	1.2	-0.9	-1.1	-0.4	-0.5	-0.5	-0.7	0.6	0.5
Patch foraging water rate 24 sec	0.8	1.1	2.1	-1.4	-0.8	-1.4	-1.3	0.6	0.6	-0.9	-0.8
Patch foraging water rate 6 sec	0.4	0.6	1.3	-1.2	-0.8	-1.1	-1.2	0.2	0.3	-0.1	-0.7
Seeking ratio, delayed vs. immediate footshock	1.2	1.4	3.2	1.8	1.7	1.5	1.6	0.4	0.6	-0.6	0.2
Distance traveled before self-admin	0.2	0.2	0.6	0.7	0.8	0.5	0.5	0.2	0.2	-0.1	0.0
Distance traveled after self-admin	1.4	1.7	3.2	1.0	1.6	0.1	0.3	1.7	1.6	-1.8	-1.2
Extensor digitorum longus weight	0.6	2.5	5.8	0.7	-0.2	1.5	1.4	-1.8	-1.8	2.4	1.6
Bone: elastic displacement	0.8	1.0	2.5	1.2	1.6	0.8	0.9	0.5	0.7	-0.8	-1.0
Bone: elastic work	1.2	1.5	4.1	1.3	2.0	0.6	0.8	1.1	1.2	-0.9	-1.4
Bone: endosteal estimation	1.4	3.1	5.8	-1.1	-1.9	-0.1	-0.4	-2.2	-2.3	2.4	1.9
Bone: endosteal perimeter	1.7	3.6	6.8	-1.7	-2.6	-0.7	-1.1	-2.1	-2.1	2.2	1.9
Epididymis fat weight	0.6	1.9	3.3	1.4	0.9	1.8	1.8	-1.2	-1.2	0.2	1.7
Delta time in closed arm before/after self-admin	1.2	1.1	2.0	1.2	0.5	1.4	1.4	-0.9	-0.8	1.1	0.9
Delta time in open arm before/after self-admin	1.6	1.6	3.4	-1.6	-1.8	-1.0	-1.2	-1.0	-0.8	1.4	0.5
Diff in mean of infusions in LGA sessions	3.0	3.7	7.8	2.8	2.8	2.1	2.3	1.1	1.0	-1.4	-0.3
Delay discount exponential model param	0.1	0.1	0.4	0.2	0.2	0.3	0.2	-0.7	-0.3	0.5	0.3
Extinction: sum of active levers before priming	0.2	0.3	0.7	0.0	-0.6	0.3	0.2	-0.8	-0.7	0.2	0.6
Active lever presses in extinction session 6	4.1	4.0	6.5	-2.0	-0.6	-2.6	-2.4	1.8	1.6	-2.0	-2.4
Bone: final force	0.1	0.1	0.3	-0.2	0.3	-0.4	-0.5	-0.1	0.1	0.5	-0.6
Bone: final moment	0.1	0.2	0.5	-0.3	0.0	-0.4	-0.5	-0.3	-0.2	0.7	-0.4
Food consumed during 24 hour testing period	1.5	2.0	5.0	-1.8	-1.7	-2.1	-2.2	0.2	0.3	-0.2	-0.6
Glucose	0.1	0.2	0.6	0.1	-0.2	0.3	0.4	-0.4	-0.5	-0.1	0.8
Heart weight	0.4	0.6	1.5	-1.2	-0.9	-1.0	-1.1	-0.3	-0.3	0.5	-0.0
Delay discount hyperbolic model param	0.1	0.1	0.2	0.3	0.4	0.3	0.2	-0.4	-0.0	0.3	0.1
Intermittent access intake day 1-15 change	1.0	2.1	4.5	-1.8	-1.2	-2.1	-2.0	0.7	0.8	-0.8	-1.2
Intermittent access intake escalation	1.1	2.3	5.0	-1.9	-1.3	-2.2	-2.2	0.7	0.8	-0.8	-1.3
Intermittent access intake escalation 2	1.0	1.2	2.6	-1.5	-1.0	-1.6	-1.6	0.4	0.4	-0.2	-0.8
Intermitt. access day 1 inactive lever presses	0.5	1.8	4.1	1.7	2.0	1.1	1.2	1.4	1.2	-0.8	-0.9
Intermitt. access day 15 inactive lever presses	0.9	1.8	4.0	1.5	2.0	0.9	0.9	1.4	1.3	-1.2	-1.1
Intermitt. access escalation Index	0.1	0.2	0.4	0.2	0.6	-0.0	0.0	0.6	0.6	0.0	-0.5
Intermittent access day 1 total infusions	0.3	0.4	1.0	-0.9	-0.7	-1.0	-0.9	0.0	0.2	0.3	-0.4
Intermittent access day 15 total infusions	1.5	2.3	4.8	-1.9	-1.3	-2.2	-2.2	0.7	0.8	-0.5	-1.4
Intermittent access terminal intake (last 3 days)	1.4	1.8	4.1	-1.9	-1.5	-2.0	-2.0	0.0	0.2	0.1	-0.8
Intermittent access total infusions	0.7	0.9	1.8	-1.3	-1.2	-1.3	-1.2	-0.2	-0.0	0.7	-0.3
Intermittent access day 1 locomotion	0.3	0.3	0.7	-0.5	-0.0	-0.6	-0.7	0.6	0.7	-0.1	-0.8
Intermittent access day 15 total locomotion	1.0	1.8	3.9	-1.7	-1.1	-2.0	-1.9	0.7	0.8	-0.7	-1.2
Intermittent access total locomotion	0.5	0.7	1.5	-1.1	-0.9	-1.1	-1.2	0.1	0.2	0.1	-0.4
Intermittent access standard deviation	0.3	0.7	1.6	-0.3	-0.9	0.3	0.1	-0.9	-1.0	1.3	0.9
Left kidney weight	0.9	4.1	8.9	0.2	-1.3	1.2	1.0	-2.7	-2.8	2.3	3.0
Right kidney weight	1.1	4.8	9.4	0.1	-1.5	1.1	1.0	-2.9	-3.1	2.6	3.0
Cocaine induced anxiety	0.8	1.1	2.3	1.5	1.4	1.4	1.5	0.1	0.1	-0.1	0.4
Post-drug Anxiety	0.9	0.9	2.1	1.5	1.3	1.3	1.2	0.2	0.2	-0.1	0.2
Baseline Anxiety	0.1	0.1	0.3	-0.5	-0.6	-0.4	-0.5	-0.1	-0.1	0.2	-0.2
Tail length	2.4	9.3	17.7	0.2	-2.0	2.0	1.6	-4.2	-4.2	3.8	3.7
Length with tail	1.4	5.9	13.4	0.1	-1.4	1.5	1.3	-3.7	-3.5	2.7	3.0
Length without tail	0.1	0.2	0.5	0.7	0.6	0.4	0.5	-0.2	-0.0	-0.6	0.2
Times rat made contact with spout	0.8	0.9	1.5	0.9	0.1	1.2	1.0	-1.2	-1.1	0.8	0.8
Lifetime Intake	0.9	1.1	2.3	-1.5	-1.3	-1.5	-1.4	0.0	0.2	0.4	-0.5
Liver weight, left	0.8	1.3	1.9	0.8	-0.2	1.4	1.2	-1.2	-1.3	1.3	1.4
Liver weight, right	2.7	4.7	7.2	2.1	0.3	2.7	2.5	-2.2	-2.3	1.5	2.7
Locomotor activity	0.6	1.0	1.9	-1.1	-1.4	-0.7	-0.8	-1.2	-0.9	0.8	0.6
Locomotor testing distance	1.6	2.8	5.1	-1.4	-2.1	-0.3	-0.7	-2.3	-2.1	1.7	1.7
Locomotor testing rearing	1.1	2.3	5.0	-0.4	-1.3	0.8	0.4	-2.2	-2.1	1.7	1.8
Locomotion in novel chamber	0.7	0.9	1.8	-1.3	-0.8	-1.2	-1.4	0.6	0.6	-0.7	-0.7
Locomotion in novel chamber post-restriction	1.9	3.1	6.6	-2.5	-1.7	-2.5	-2.6	0.5	0.2	-0.9	-1.3
Fecal boli incidents, locomotor time 1	0.4	0.6	1.3	-1.0	-0.5	-1.1	-1.0	0.1	0.3	-0.5	-1.0
Change in fecal boli incidents, locomotor task	0.4	0.4	0.7	0.8	0.8	0.7	0.6	0.6	0.6	-0.6	-0.1
Time >=10cm from walls, locomotor time 1	1.4	1.5	3.1	-1.8	-1.0	-1.7	-1.6	0.6	0.7	-0.7	-1.2
Bouts of movement, locomotor time 1	0.1	0.1	0.2	-0.2	-0.3	-0.4	0.0	-0.1	-0.4	-0.3	-0.0
Total resting periods, locomotor time 1	0.2	0.2	0.5	-0.1	0.1	-0.5	0.0	0.5	0.2	-0.7	-0.6
Rest time, locomotor task time 1	0.6	0.7	1.9	0.4	0.6	-0.1	0.1	1.4	1.0	-1.2	-0.9
Distance moved, locomotor task time 1	1.0	1.4	3.0	-0.3	-1.0	0.5	0.2	-1.5	-1.4	1.7	1.7
Vertical activity count, locomotor time 1	0.5	1.2	2.4	-0.8	-1.1	-0.1	-0.5	-1.2	-1.3	1.6	1.3
Time >=10cm from walls, locomotor time 2	0.3	0.5	1.5	-1.1	-1.2	-0.8	-0.6	-0.2	-0.5	0.0	0.3
Bouts of movement, locomotor time 2	0.2	0.4	1.2	-0.8	-1.1	-0.6	-0.3	-0.6	-0.4	0.3	0.0
Total resting periods, locomotor time 2	0.1	0.2	0.6	-0.6	-0.8	-0.5	-0.2	-0.5	-0.2	0.1	-0.1
Rest time, locomotor task time 2	0.9	1.2	2.6	1.6	1.6	1.4	1.3	0.1	0.4	-0.5	-0.3
Distance moved, locomotor task time 2	1.4	1.7	3.9	-1.6	-2.0	-1.0	-1.1	-0.8	-1.2	0.9	1.2
Vertical activity count, locomotor time 2	1.0	1.3	2.4	-1.1	-1.5	-0.4	-0.6	-1.0	-1.3	1.3	1.4
Light reinforcement 1	0.5	1.2	3.4	1.8	1.5	1.4	1.5	-0.1	-0.1	-0.4	0.2
Light reinforcement 2	0.2	0.3	0.5	0.1	0.2	-0.5	-0.4	0.6	0.5	-0.7	-0.6
Bone: marrow area	1.3	2.9	5.6	-1.0	-1.8	0.0	-0.3	-2.2	-2.2	2.4	1.9
Bone: maximum diameter	1.6	3.0	5.1	-1.8	-2.3	-0.9	-1.2	-2.0	-1.9	2.1	1.2
Bone: maximum force	0.2	0.3	0.7	-0.4	0.2	-0.7	-0.8	0.1	0.2	0.5	-0.8
Bone: maximum moment	0.2	0.3	0.6	-0.5	-0.0	-0.7	-0.8	-0.0	-0.0	0.7	-0.7
Mean time between licks in bursts	1.4	3.4	7.4	-1.6	-2.7	-1.0	-1.1	-1.8	-2.1	1.8	2.0
Mean num. licks in bursts	1.4	2.2	5.2	-2.3	-2.1	-1.8	-1.7	-0.3	-0.4	1.2	-0.1
Cd content in liver	1.0	1.2	1.9	0.9	0.5	1.3	1.4	-1.3	-1.1	0.8	1.1
Co content in liver	0.9	1.0	2.2	-0.6	-1.2	0.1	0.0	-1.1	-1.3	1.5	1.2
Cu content in liver	1.5	1.7	3.8	0.4	-0.8	1.0	0.8	-1.5	-1.8	1.5	1.9
Fe content in liver	0.0	0.0	0.1	0.1	0.3	0.0	-0.2	-0.0	-0.1	-0.2	-0.1
K content in liver	0.2	0.2	0.6	0.5	0.3	0.3	0.4	0.8	0.5	0.3	0.2
Mg content in liver	0.2	0.2	0.5	-0.3	-0.2	-0.5	-0.3	0.7	0.6	-0.3	-0.2
Mn content in liver	1.4	1.6	2.8	0.7	1.3	-0.2	-0.1	1.7	1.7	-1.7	-1.4
Na content in liver	1.0	1.1	1.9	-1.1	-0.6	-1.3	-1.4	0.9	0.9	-0.7	-1.1
Rb content in liver	0.1	0.2	0.9	-0.3	-0.3	0.1	0.1	-0.0	-0.1	1.0	0.4
Se content in liver	3.4	4.0	9.7	2.7	3.1	1.5	1.9	1.6	1.6	-1.9	-1.0
Sr content in liver	0.2	0.2	0.4	-0.5	-0.1	-0.4	-0.4	-0.2	-0.0	-0.5	-0.6
Zn content in liver	1.7	1.9	4.0	-1.3	-2.0	-0.7	-0.6	-1.3	-1.7	1.3	1.6
Bone: minimum diameter	2.1	3.7	7.3	0.0	-1.1	1.0	0.7	-2.6	-2.6	2.7	2.4
Time in familiar zone, hab. session 1	0.1	0.1	0.3	0.5	0.2	0.5	0.5	-0.1	0.0	0.1	0.2
Time in novel zone, hab. session 1	0.2	0.2	0.5	0.2	0.1	0.3	0.3	-0.7	-0.7	0.5	0.4
Total zone transitions, hab. session 1	0.7	1.0	1.9	-0.6	0.1	-1.0	-1.0	0.8	1.1	-1.2	-1.4
Total locomotion distance, hab. session 1	1.3	1.8	2.8	1.4	0.8	1.7	1.7	-1.4	-1.2	0.9	1.4
Locomotion velocity, hab. session 1	0.8	1.2	1.7	1.1	0.6	1.3	1.3	-1.2	-1.1	0.7	1.1
Time in familiar zone, hab. session 2	1.0	1.0	2.0	-1.0	-1.4	-0.5	-0.6	-1.2	-0.9	1.3	1.0
Time in novel zone, hab. session 2	0.4	0.4	1.2	0.4	0.7	0.2	0.3	0.8	0.4	-1.1	-0.6
Total zone transitions, hab. session 2	1.4	1.8	3.8	-1.5	-0.5	-2.0	-1.8	0.9	0.7	-1.3	-1.4
Total locomotion distance, hab. session 2	0.7	0.9	1.9	0.7	0.2	0.8	0.7	-1.2	-1.4	0.9	1.1
Locomotion velocity, hab. session 2	0.8	1.1	2.2	0.8	0.2	1.0	0.9	-1.2	-1.5	1.0	1.2
Novel to familiar place preference ratio	0.2	0.2	0.4	-0.4	-0.1	-0.6	-0.5	0.2	-0.0	-0.4	-0.5
Novelty place preference	0.1	0.1	0.2	-0.2	-0.1	-0.4	-0.4	0.2	-0.1	-0.4	-0.3
Time in novel zone, NPP test	0.1	0.2	0.4	-0.4	-0.2	-0.6	-0.5	0.1	-0.1	-0.4	-0.4
Total zone transitions, NPP test	0.6	0.9	1.7	-0.4	0.2	-1.1	-0.9	1.2	1.0	-1.3	-1.1
Total locomotion distance, NPP test	0.8	1.1	2.3	1.5	1.0	1.2	1.4	-0.6	-0.9	0.2	1.2
Locomotion velocity, NPP test	1.1	1.5	3.2	1.8	1.2	1.5	1.6	-0.5	-0.8	0.1	1.2
Intraocular pressure	0.7	1.0	2.3	-1.1	-0.3	-1.5	-1.4	0.4	0.5	-0.9	-1.1
Delta distance traveled before/after self-admin	1.0	1.0	1.5	-0.8	-0.1	-1.2	-1.1	1.1	1.0	-1.1	-1.2
Delta ambulatory time before/after self-admin	0.9	1.2	1.7	-0.8	-0.1	-1.3	-1.1	1.2	1.1	-1.3	-1.3
Parametrial fat weight	0.2	0.5	0.9	0.9	0.5	0.8	0.9	-0.6	-0.7	0.1	0.5
Pavlov. Cond. lever latency	0.3	0.4	1.1	0.9	1.1	0.5	0.6	0.4	0.5	-0.5	-0.4
Pavlov. Cond. magazine entry latency	1.6	2.1	3.9	-1.9	-2.0	-1.2	-1.3	-1.5	-1.3	1.2	0.6
Pavlov. Cond. change in total contacts	0.3	0.3	0.6	-0.8	-0.7	-0.6	-0.6	-0.4	-0.5	-0.0	0.2
Pavlov. Cond. index score	1.2	1.5	2.9	-1.4	-1.7	-0.7	-0.8	-1.3	-1.3	1.1	0.9
Pavlov. Cond. latency score	1.0	1.3	2.6	-1.5	-1.6	-0.8	-0.9	-1.2	-1.2	1.0	0.8
Pavlov. Cond. lever contacts	0.4	0.4	0.8	-0.7	-0.9	-0.1	-0.2	-0.7	-0.8	0.7	0.7
Pavlov. Cond. magazine entry number	1.6	2.0	3.9	1.8	2.0	1.1	1.2	1.5	1.4	-1.0	-0.8
Pavlov. Cond. intertrial magazine entries	1.1	1.3	2.9	1.7	1.5	1.3	1.7	0.6	0.2	-0.5	0.3
Pavlov. Cond. lever-magazine prob. diff.	0.9	1.1	2.2	-1.3	-1.5	-0.5	-0.7	-1.1	-1.1	1.1	0.8
Pavlov. Cond. response bias	0.5	0.6	1.1	-0.8	-1.0	-0.4	-0.4	-1.0	-1.0	0.7	0.7
Pavlov. Cond. lever latency	11.3	15.4	34.9	5.9	5.6	5.1	5.3	1.1	1.1	-0.8	0.2
Pavlov. Cond. magazine entry latency	3.4	4.1	9.7	-3.1	-2.3	-2.8	-2.8	0.3	0.3	-0.0	-1.1
Pavlov. Cond. change in total contacts	6.3	10.1	23.7	-4.9	-4.6	-4.1	-4.1	-1.0	-1.2	0.5	0.0
Pavlov. Cond. index score	8.3	11.2	26.7	-5.2	-4.7	-4.4	-4.4	-0.8	-0.9	0.6	-0.3
Pavlov. Cond. latency score	7.6	10.1	24.1	-4.9	-4.3	-4.3	-4.3	-0.6	-0.6	0.3	-0.5
Pavlov. Cond. lever contacts	10.5	14.5	32.8	-5.7	-5.4	-4.9	-5.0	-1.2	-1.2	0.9	-0.1
Pavlov. Cond. magazine entry number	4.0	5.0	12.8	3.6	2.9	3.0	3.0	0.2	0.3	0.1	0.5
Pavlov. Cond. intertrial magazine entries	1.2	1.8	3.7	0.5	-0.6	0.8	0.7	-1.9	-1.8	1.8	1.6
Pavlov. Cond. lever-magazine prob. diff.	7.7	10.2	24.3	-4.9	-4.5	-4.2	-4.2	-0.8	-0.9	0.6	-0.2
Pavlov. Cond. response bias	10.6	14.4	33.6	-5.8	-5.4	-4.9	-5.0	-1.1	-1.1	0.9	-0.1
Time in closed arm before self-admin	0.8	1.0	1.5	-1.1	-0.3	-1.2	-1.2	1.0	0.8	-0.9	-0.9
Time in closed arm after self-admin	1.0	1.1	1.9	0.9	1.2	0.2	0.4	1.4	1.3	-1.1	-1.2
Time in open arm before self-admin	1.1	1.1	2.8	1.7	1.5	1.3	1.4	0.1	0.0	-0.7	0.2
Time in open arm after self-admin	0.9	1.0	2.5	-0.5	-0.9	0.2	-0.0	-1.4	-1.1	1.6	1.1
Bone: periosteal estimation	1.5	3.1	6.0	-1.1	-1.8	-0.0	-0.4	-2.3	-2.4	2.4	1.9
Bone: periosteal perimeter	1.6	2.8	4.4	-1.2	-2.0	-0.3	-0.6	-2.1	-2.0	2.1	1.8
Bone: post-yield work	0.1	0.2	0.4	-0.6	-0.4	-0.4	-0.6	-0.1	-0.1	0.5	-0.4
Progressive ratio test 1 active lever presses	0.4	0.5	1.1	-0.0	0.5	-0.6	-0.5	0.8	1.0	-0.7	-1.1
Progressive ratio test 1 breakpoint	0.4	0.5	1.1	-0.0	0.5	-0.6	-0.5	0.8	1.0	-0.7	-1.0
Progressive ratio test 1 inactive lever presses	0.4	0.6	1.4	0.4	1.0	-0.2	-0.1	1.0	1.1	-0.5	-1.2
Progressive ratio test 2 active lever presses	0.4	0.5	1.0	-0.9	-1.0	-0.8	-0.8	-0.5	-0.4	0.3	0.2
Progressive ratio test 2 breakpoint	0.4	0.5	1.0	-0.9	-1.0	-0.9	-0.8	-0.5	-0.4	0.3	0.1
Progressive ratio test 2 inactive lever presses	0.1	0.1	0.3	-0.6	-0.4	-0.5	-0.5	-0.2	-0.0	0.2	-0.1
Incentive Sensitization - Responses	0.8	1.1	2.5	-1.4	-1.6	-0.9	-1.0	-1.0	-0.9	0.7	0.6
Incentive Sensitization - Breakpoint	0.8	1.0	2.2	-1.3	-1.5	-0.9	-1.0	-0.9	-0.8	0.6	0.6
Sum of active levers in priming session hrs 5-6	0.1	0.1	0.3	-0.2	-0.3	-0.2	-0.1	0.1	0.0	-0.6	-0.2
Progressive ratio	0.4	0.6	1.3	-0.8	-0.2	-1.0	-1.1	0.7	0.7	-0.5	-0.7
Food seeking constrained by brief footshock	1.4	1.7	4.4	-1.5	-2.1	-1.0	-1.2	-1.4	-1.1	1.2	0.6
Seeking ratio, punishment vs. effort	1.0	1.5	3.4	-0.4	-1.4	0.2	0.2	-1.8	-1.6	1.6	1.3
Retroperitoneal fat weight	3.3	14.3	22.8	3.3	0.9	4.8	4.5	-3.8	-3.8	3.1	4.6
Reaction time number correct	0.7	1.3	2.1	-0.5	0.3	-1.2	-0.9	1.3	1.4	-1.4	-1.4
Reaction time mean minus median	0.5	1.2	2.7	-1.2	-1.6	-0.7	-0.8	-1.1	-1.1	1.2	0.5
Reaction time mean minus median AUC	0.4	1.1	2.5	-1.4	-1.6	-1.1	-1.3	-0.6	-0.6	0.6	-0.0
Reaction time num false alarms	1.2	1.7	4.0	2.0	1.7	1.6	1.8	-0.2	-0.1	0.3	0.9
Reaction time num false alarms AUC	0.6	1.0	2.5	1.6	1.4	1.0	1.3	0.1	0.2	-0.0	0.6
Reaction time trials correct on left	0.7	1.3	2.1	-0.5	0.3	-1.2	-0.9	1.3	1.4	-1.4	-1.4
Reaction time trials on left	0.7	1.3	2.1	-0.5	0.3	-1.3	-0.9	1.4	1.4	-1.5	-1.4
Reaction time mean	0.2	0.4	0.8	0.6	0.1	0.9	0.7	-0.4	-0.5	0.9	0.1
Reaction time mean AUC	0.3	0.4	1.1	1.0	0.5	1.1	0.9	-0.1	-0.2	0.5	-0.1
Median of all reaction times	0.4	0.6	1.4	1.1	0.7	1.2	1.0	0.1	-0.0	0.5	-0.2
Reaction time omissions	0.2	0.2	0.7	-0.1	-0.5	0.1	-0.1	-0.8	-0.8	0.2	0.5
Reaction time false alarm rate	1.1	1.5	3.1	1.8	1.4	1.6	1.7	-0.4	-0.4	0.5	1.0
Reaction time premature initiation rate	2.5	3.5	6.8	-1.0	-1.8	0.3	0.0	-2.6	-2.5	2.6	2.0
Reaction time premature initiations	1.0	1.7	2.8	-1.3	-1.6	-0.6	-0.6	-1.7	-1.6	1.5	1.0
Std. dev. reaction times	0.7	1.3	3.0	-0.5	-1.2	0.3	0.1	-1.5	-1.5	1.7	1.1
Reaction time trials completed	0.7	1.3	2.1	-0.5	0.3	-1.3	-0.9	1.4	1.4	-1.5	-1.4
Reaction time trials AUC	0.5	1.0	1.6	-0.5	0.1	-1.2	-0.8	1.1	1.2	-1.3	-1.2
Run reversals in cocaine runway, females	3.3	3.3	4.9	1.0	-0.1	1.9	1.7	-2.2	-2.1	2.2	2.2
Run reversals in cocaine runway, males	0.3	0.3	1.2	-0.0	0.1	-0.3	-0.3	0.7	0.6	-0.1	-1.1
Latency to leave start box in cocaine runway	1.3	1.5	3.5	1.9	1.7	1.4	1.5	0.8	0.4	-0.6	-0.0
Latency to leave start box in cocaine runway, F	1.4	1.5	3.8	2.0	1.5	1.6	1.7	-0.0	-0.4	-0.1	0.9
Latency to leave start box in cocaine runway, M	0.7	0.7	1.3	0.4	0.7	0.1	0.2	1.2	1.1	-0.9	-1.1
Std. dev. time between licks in bursts	1.3	1.7	4.0	-0.5	-1.5	0.0	0.0	-1.9	-1.7	1.1	2.0
Total sessions with >9 infusions	1.1	1.3	2.9	-1.7	-1.3	-1.6	-1.7	0.1	0.4	0.2	-0.6
Short access day 1 total inactive lever presses	0.0	0.1	0.1	-0.0	-0.2	-0.1	-0.2	0.3	0.3	-0.1	-0.4
Short access day 10 total inactive lever presses	0.4	1.0	2.6	1.3	1.6	1.0	1.0	0.9	0.7	-0.6	-0.5
Short access day 1 total infusions	1.3	1.7	4.2	-1.9	-2.0	-1.5	-1.6	-0.6	-0.4	1.0	0.1
Short access day 10 total infusions	0.4	0.6	1.2	-1.1	-1.0	-1.1	-0.9	-0.1	0.1	0.5	-0.2
Short access total infusions	1.0	1.2	2.7	-1.6	-1.4	-1.6	-1.6	0.1	0.3	0.3	-0.5
Short access day 1 locomotion	2.2	2.7	5.8	-2.3	-1.4	-2.4	-2.4	0.7	0.8	-0.5	-1.4
Short access day 10 total locomotion	0.5	1.0	2.4	-1.5	-1.4	-1.2	-1.4	-0.2	-0.2	0.3	-0.0
Short access total locomotion	0.9	1.1	2.3	-1.3	-0.6	-1.3	-1.5	0.7	0.8	-0.3	-1.0
One hour access (0.3 mA shock)	0.6	0.7	1.7	-1.3	-1.1	-1.1	-1.0	-0.4	-0.3	0.4	-0.0
Compulsive drug intake	0.7	0.8	2.8	0.2	0.9	-0.5	-0.1	1.1	0.9	-1.7	-0.9
One hour access (shock baseline)	0.7	1.1	2.4	-1.5	-1.4	-1.3	-1.4	-0.1	-0.0	0.6	-0.4
Social response proportion	0.4	0.5	1.2	1.0	0.7	1.0	1.1	-0.1	-0.2	0.0	0.2
Social responses	1.2	1.5	2.5	1.3	0.6	1.5	1.6	-1.2	-1.3	0.9	1.2
Social time	1.7	2.3	5.1	2.1	2.3	1.4	1.5	1.1	0.9	-1.5	-0.7
Soleus weight	1.4	4.1	8.9	1.1	-0.2	2.1	1.7	-2.2	-2.3	3.0	2.4
Bone: stiffness	0.1	0.2	0.6	0.4	0.8	-0.1	-0.2	0.2	0.4	0.2	-0.7
Tibialis anterior weight	0.2	0.7	2.5	-0.2	-0.6	0.2	0.2	-1.1	-1.1	1.6	0.7
Time to tail flick, vehicle, before self-admin	0.2	0.2	0.6	-0.1	-0.1	0.3	0.3	-0.6	-0.4	0.8	0.5
Time to tail flick, vehicle, after self-admin	0.6	0.8	1.7	-1.3	-1.1	-1.1	-1.2	-0.4	-0.2	0.7	-0.2
Time to tail flick, test, before self-admin	0.9	0.9	2.3	-0.1	-0.8	0.5	0.4	-1.1	-1.2	1.5	1.2
Time to tail flick, test, after self-admin	0.9	0.9	1.7	0.2	-0.6	0.8	0.8	-1.1	-1.3	1.1	1.3
Delta time to tail flick, vehicle, before/after SA	1.1	1.0	2.2	-1.3	-0.9	-1.5	-1.5	0.4	0.4	-0.3	-0.9
Delta time to tail flick, test, before/after SA	0.4	0.4	0.6	0.6	0.7	0.4	0.5	0.6	0.6	-0.8	-0.5
Tibia length	1.0	2.8	6.3	-2.5	-1.5	-2.4	-2.3	0.4	0.4	-0.8	-1.2
Ambulatory time before self-admin	0.4	0.6	1.2	0.8	1.1	0.3	0.3	0.8	0.9	-1.0	-0.6
Ambulatory time after self-admin	1.7	2.0	4.6	0.5	1.3	-0.4	-0.2	1.9	1.8	-2.1	-1.6
Bone: tissue strength	1.6	1.7	4.2	-0.0	1.3	-0.8	-0.6	1.5	1.6	-1.3	-2.1
Total heroin consumption	0.0	0.0	0.1	0.1	0.1	0.1	0.1	0.3	0.1	-0.3	-0.3
Bone: trabecular number	0.5	0.8	2.6	1.1	1.6	0.9	1.0	0.4	0.5	-0.0	-0.6
Bone: trabecular spacing	0.7	1.0	1.8	-1.3	-1.3	-1.3	-1.4	0.1	-0.0	-0.8	-0.3
Bone: trabecular thickness	0.9	1.1	1.8	0.9	0.4	1.3	1.3	-1.2	-0.9	1.2	0.9
Bone: trabecular tissue density	0.7	1.0	2.4	1.6	0.9	1.4	1.3	-0.5	-0.4	0.6	0.6
Water consumed over 24 hours	0.4	0.5	1.3	1.2	0.9	1.0	0.9	-0.2	0.0	0.1	0.1
Number of responses in last shaping day	1.7	1.9	3.8	1.3	0.8	2.0	1.8	-1.1	-0.9	1.4	1.3