Hub : Traits

Delay discounting water rate 18 sec

Delay discounting using a sequential patch depletion procedure, water consumption rate during the last two sessions with an experimenter-imposed delay of 18 sec

Tags: Behavior · Delay discounting

Project: p50_david_dietz

9 significantly associated models · 2 unique genes

Significant Loci

# chr p0 p1 # assoc genes # joint models best TWAS P best SNP P cond SNP P % var exp joint genes
1 1 140614300 142727457 2 1 1.9e-10 3.5e-09 0.36 98 Grm5

p0: physical position of the start of the locus. p1: physical position of the end of the locus. # joint models: number of models selected by step-wise conditional analysis.

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Left kidney weight 2.8 2 0 0 0.00 1.0e+00 Grm5 Ctsc
Liver weight, right 5.2 1 0 0 0.00 1.0e+00 Grm5
Intraocular pressure 12.9 2 0 0 1.00 5.0e-11 Grm5 Ctsc
Mean time between licks in bursts 7.4 2 0 0 -1.00 1.7e-06 Grm5 Ctsc
Delay discounting time to switch 0 sec 9.4 2 0 0 -1.00 3.5e-10 Grm5 Ctsc
Delay discounting water rate 0 sec 6.7 2 0 0 1.00 1.0e-05 Grm5 Ctsc
Delay discounting water rate 12 sec 14.2 2 2 200 1.00 9.7e-10 Grm5 Ctsc
Delay discounting water rate 24 sec 7.5 2 0 0 1.00 9.4e-10 Grm5 Ctsc
Delay discounting water rate 6 sec 8.1 2 0 0 1.00 8.4e-11 Grm5 Ctsc
Locomotor activity 5.4 2 0 0 1.00 4.0e-04 Grm5 Ctsc
Light reinforcement 1 11.4 2 0 0 -0.99 5.0e-08 Grm5 Ctsc
Light reinforcement 2 21.1 2 2 200 -0.98 1.9e-06 Grm5 Ctsc
Reaction time num false alarms 14.5 2 0 0 -1.00 1.1e-09 Grm5 Ctsc
Reaction time num false alarms AUC 11.3 2 0 0 -1.00 6.0e-10 Grm5 Ctsc
Reaction time false alarm rate 14.5 2 0 0 -1.00 2.2e-10 Grm5 Ctsc
Short access day 1 total infusions 8.7 2 0 0 -1.00 1.9e-06 Grm5 Ctsc
Locomotion velocity, session 1 16.4 2 0 0 0.99 1.6e-07 Grm5 Ctsc
Locomotion velocity, session 2 8.0 2 0 0 1.00 3.2e-05 Grm5 Ctsc
Locomotion distance, session 3 10.1 2 0 0 1.00 2.8e-05 Grm5 Ctsc
Stereotopy head waving bouts, day 3 9.3 2 0 0 -0.99 2.2e-07 Grm5 Ctsc
Locomotion velocity, session 8 7.9 2 0 0 1.00 5.8e-09 Grm5 Ctsc
Total zone transitions, hab. session 1 7.2 2 0 0 1.00 2.5e-04 Grm5 Ctsc
Total locomotion distance, hab. session 1 29.1 2 2 200 -0.99 4.8e-07 Grm5 Ctsc
Locomotion velocity, hab. session 1 29.6 2 2 200 -0.99 6.4e-07 Grm5 Ctsc
Total locomotion distance, hab. session 2 37.2 2 2 200 -0.99 5.6e-07 Grm5 Ctsc
Locomotion velocity, hab. session 2 34.2 2 2 200 -0.99 8.2e-07 Grm5 Ctsc
Total locomotion distance, NPP test 39.2 2 2 200 -0.98 1.4e-06 Grm5 Ctsc
Locomotion velocity, NPP test 37.9 2 2 200 -0.98 1.4e-06 Grm5 Ctsc
Bone: minimum diameter 4.2 1 0 0 0.00 1.0e+00 Ctsc
Time to tail flick, vehicle, after self-admin 8.0 1 0 0 0.00 1.0e+00 Grm5
Vertical activity count, locomotor time 2 9.1 2 0 0 0.00 1.0e+00 Grm5 Ctsc
Latency to leave start box in cocaine runway 10.8 2 0 0 -0.99 4.2e-07 Grm5 Ctsc
Latency to leave start box in cocaine runway, F 9.6 1 0 0 0.00 1.0e+00 Ctsc
Latency to leave start box in cocaine runway, M 8.8 2 0 0 0.00 1.0e+00 Grm5 Ctsc
Cd content in liver 7.7 2 0 0 -1.00 2.4e-07 Grm5 Ctsc

chisq ratio: Average Chi2 statistic for the selected genes in the secondary trait, divided by the average statistic for all genes in the secondary trait. # genes+: Shared significant genes at Bonferroni correction. # genes++: Shared significant genes at transcriptome-wide significance. % genes++: Number of [++] genes as a percentage of primary trait’s total joint genes. corr: Correlation of effect sizes across the [+] genes.

Associations by panel

tissue modality # hits % hits/tests avg chisq
Adipose alternative polyA 0 0.000 1.3
Adipose alternative TSS 0 0.000 1.3
Adipose gene expression 0 0.000 1.3
Adipose isoform ratio 0 0.000 1.3
Adipose intron excision ratio 0 0.000 1.3
Adipose mRNA stability 0 0.000 1.3
BLA alternative polyA 2 0.167 1.4
BLA alternative TSS 0 0.000 1.3
BLA gene expression 1 0.016 1.3
BLA isoform ratio 0 0.000 1.3
BLA intron excision ratio 0 0.000 1.4
BLA mRNA stability 1 0.049 1.4
Brain alternative polyA 0 0.000 1.3
Brain alternative TSS 0 0.000 1.3
Brain gene expression 1 0.011 1.4
Brain isoform ratio 1 0.032 1.3
Brain intron excision ratio 0 0.000 1.4
Brain mRNA stability 0 0.000 1.3
Eye alternative polyA 0 0.000 1.0
Eye alternative TSS 0 0.000 1.1
Eye gene expression 1 0.089 1.2
Eye isoform ratio 0 0.000 1.2
Eye intron excision ratio 0 0.000 1.2
Eye mRNA stability 0 0.000 1.2
IL alternative polyA 0 0.000 1.4
IL alternative TSS 0 0.000 1.2
IL gene expression 1 0.027 1.3
IL isoform ratio 0 0.000 1.3
IL intron excision ratio 0 0.000 1.4
IL mRNA stability 0 0.000 1.4
LHb alternative polyA 0 0.000 1.3
LHb alternative TSS 0 0.000 1.4
LHb gene expression 0 0.000 1.4
LHb isoform ratio 0 0.000 1.4
LHb intron excision ratio 0 0.000 1.3
LHb mRNA stability 0 0.000 1.3
Liver alternative polyA 0 0.000 1.3
Liver alternative TSS 0 0.000 1.3
Liver gene expression 0 0.000 1.4
Liver isoform ratio 0 0.000 1.3
Liver intron excision ratio 0 0.000 1.3
Liver mRNA stability 0 0.000 1.3
NAcc alternative polyA 0 0.000 1.3
NAcc alternative TSS 0 0.000 1.4
NAcc gene expression 0 0.000 1.3
NAcc isoform ratio 0 0.000 1.3
NAcc intron excision ratio 0 0.000 1.3
NAcc mRNA stability 0 0.000 1.3
OFC alternative polyA 0 0.000 1.4
OFC alternative TSS 0 0.000 1.3
OFC gene expression 0 0.000 1.3
OFC isoform ratio 0 0.000 1.3
OFC intron excision ratio 0 0.000 1.3
OFC mRNA stability 0 0.000 1.3
PL alternative polyA 0 0.000 1.4
PL alternative TSS 0 0.000 1.4
PL gene expression 0 0.000 1.4
PL isoform ratio 0 0.000 1.4
PL intron excision ratio 0 0.000 1.3
PL mRNA stability 1 0.034 1.3

avg chisq: Average Chi2 (squared Z-score) across all models in this panel for this trait.