Hub : Genes

Wnt11

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 pVTA mRNA stability Wnt11 0.04 0.03 5.1e-03 0.01 0.01 0 0.01 6.5e-02 6.1e-02 1.3e-01 9.7e-02
2 BLA gene expression Wnt11 0.28 0.13 8.8e-13 0.19 0.21 0.19 0.18 2.6e-10 1.7e-11 1.6e-10 1.1e-09
3 BLA alternative polyA XM_006229718.5 0.08 0.06 4.9e-03 0.03 0.04 0.02 0.03 1.6e-02 3.9e-03 2.1e-02 1.2e-02
4 BLA alternative polyA XM_006229718.5 0.08 0.06 3.3e-03 0.03 0.04 0.03 0.03 1.8e-02 2.3e-03 1.6e-02 1.1e-02
5 pVTA alternative polyA NM_080401.1 0.25 0.13 3.5e-14 0.18 0.18 0.18 0.19 2.6e-14 4.5e-14 2.7e-14 4.8e-15
6 pVTA alternative polyA NM_080401.1 0.24 0.12 7.2e-14 0.17 0.17 0.18 0.19 8.1e-14 7.5e-14 2.9e-14 4.6e-15
7 PL alternative polyA XM_006229718.5 0.08 0.05 3.8e-07 0.06 0.07 0.07 0.07 1.3e-06 4.1e-08 5.4e-08 9.1e-08
8 Brain alternative polyA XM_006229718.5 0.09 0.06 6.7e-06 0.05 0.06 0.05 0.05 9.4e-06 5.7e-06 2.9e-05 1.5e-05
9 Brain alternative polyA XM_006229718.5 0.09 0.06 5.8e-06 0.06 0.06 0.05 0.05 7.4e-06 5.2e-06 2.8e-05 2.2e-05
10 PL alternative polyA XM_006229718.5 0.09 0.06 1.4e-07 0.06 0.07 0.07 0.07 5.7e-07 1.7e-08 4.5e-08 4.3e-08
11 pVTA alternative polyA XM_006229718.5 0.23 0.12 6.1e-14 0.17 0.17 0.18 0.19 6.3e-14 6.9e-14 2.6e-14 3.3e-15
12 pVTA alternative polyA XM_006229718.5 0.24 0.12 2.2e-14 0.18 0.18 0.18 0.19 1.4e-14 3.0e-14 2.3e-14 2.1e-15
13 RMTg gene expression Wnt11 0.14 0.1 8.4e-03 0.06 0.04 0.06 0.07 1.4e-02 3.6e-02 1.0e-02 7.4e-03
14 PL gene expression Wnt11 0.13 0.08 1.8e-11 0.09 0.09 0.08 0.08 1.6e-09 4.1e-10 2.1e-09 1.7e-09
15 NAcc alternative polyA XM_006229718.5 0.16 0.08 0.0e+00 0.15 0.16 0.16 0.16 8.5e-22 2.5e-23 2.6e-23 2.0e-23
16 NAcc alternative polyA XM_006229718.5 0.15 0.08 0.0e+00 0.15 0.16 0.16 0.16 9.7e-22 3.5e-23 6.6e-23 2.2e-23
17 IL gene expression Wnt11 0.4 0.17 4.6e-05 0.05 0.06 0.06 0.06 2.6e-02 1.8e-02 1.4e-02 1.5e-02
18 LHb gene expression Wnt11 0.83 0.11 8.5e-03 0.08 0.03 0 0.04 7.4e-03 8.6e-02 3.3e-01 3.1e-02
19 Adipose alternative TSS XM_006229718.5 0.04 0.03 8.2e-04 0.01 0.01 0.02 0.01 3.9e-02 1.2e-02 4.9e-03 2.3e-02
20 Adipose alternative TSS XM_006229718.5 0.05 0.04 1.6e-04 0.01 0.02 0.02 0.01 1.7e-02 6.2e-03 4.4e-03 9.8e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20
Bone: apparent density0.10.10.30.2-0.00.20.2-0.6-0.60.30.40.40.30.40.30.5-0.40.40.4-0.3-0.50.3-0.2
Area under the delay curve0.00.10.1-0.2-0.2-0.3-0.30.30.3-0.3-0.2-0.2-0.3-0.2-0.1-0.10.0-0.2-0.20.10.1-0.3-0.3
BMI with tail0.41.34.30.20.01.11.10.30.41.31.01.01.4-0.3-0.3-1.4-1.02.12.1-1.2-1.7-1.2-0.7
BMI without tail0.82.58.3-0.5-0.80.70.80.91.21.20.80.91.3-1.1-1.0-2.1-2.12.32.4-2.4-2.9-1.7-1.4
Body weight0.62.58.2-0.3-0.70.90.91.01.31.31.01.01.5-1.1-1.0-2.2-1.92.32.3-2.1-2.9-2.0-1.6
Weight adjusted by age0.20.31.0-0.5-0.5-0.0-0.00.60.70.1-0.1-0.10.1-0.8-0.8-0.9-0.80.40.4-1.0-0.9-0.10.0
Bone surface1.12.05.0-1.7-2.0-1.4-1.41.41.4-1.1-1.1-1.1-1.1-1.6-1.7-1.4-2.2-0.7-0.7-2.1-1.7-0.4-0.8
Bone volume0.50.92.9-1.0-1.3-0.7-0.60.80.9-0.4-0.4-0.4-0.4-1.0-1.0-1.0-1.70.00.0-1.7-1.5-0.4-0.6
Breakpoint value in progressive ratio session0.80.92.21.11.30.70.7-1.1-1.20.60.60.60.51.11.11.21.50.30.31.41.30.50.7
Number of licking bursts2.64.26.72.52.32.62.6-2.2-2.02.52.62.62.52.02.01.61.52.12.11.40.1-0.6-1.0
Context. condit. distance diff. score2.53.05.2-2.1-1.7-2.1-2.21.51.3-2.1-2.3-2.3-2.1-1.3-1.4-1.0-1.2-1.6-1.5-1.10.22.02.1
Locomotion velocity, session 10.40.52.20.81.00.40.4-0.4-0.50.10.30.20.10.50.50.81.5-0.2-0.21.11.5-0.30.0
Locomotion distance, session 10.50.71.4-0.6-0.2-0.9-0.90.80.7-1.1-1.1-1.1-1.1-0.6-0.6-0.50.6-1.2-1.20.31.20.20.6
Locomotion velocity, session 20.10.21.80.10.10.10.10.20.3-0.00.20.10.0-0.2-0.2-0.40.20.10.0-0.20.0-1.3-1.0
Locomotion distance, session 20.20.20.4-0.4-0.2-0.4-0.50.60.5-0.5-0.5-0.5-0.5-0.5-0.5-0.60.1-0.4-0.5-0.20.4-0.7-0.2
Locomotion velocity, session 30.50.52.7-0.6-0.1-0.7-0.70.40.3-0.8-1.0-1.0-0.8-0.3-0.3-0.20.3-0.5-0.5-0.01.01.31.7
Locomotion distance, session 30.90.92.0-0.8-0.3-1.1-1.10.70.6-1.2-1.4-1.4-1.3-0.5-0.5-0.30.4-1.1-1.10.31.31.01.4
Stereotopy head waving bouts, day 30.50.61.10.70.50.90.9-0.8-0.70.91.01.01.00.70.70.30.11.01.00.4-0.6-0.7-0.8
Stereotopy head waving duration, day 30.20.30.4-0.6-0.6-0.6-0.60.40.4-0.6-0.6-0.6-0.6-0.5-0.6-0.4-0.4-0.5-0.5-0.5-0.10.00.1
Locomotion velocity, session 70.50.62.20.50.80.40.4-0.9-1.00.30.10.10.31.00.90.70.80.50.50.60.81.41.5
Locomotion distance, session 70.00.10.20.20.40.30.30.20.20.30.10.10.3-0.1-0.0-0.30.30.40.4-0.10.1-0.00.2
Stereotopy head waving bouts, day 71.31.52.9-1.4-1.3-1.7-1.70.80.6-1.7-1.6-1.6-1.7-0.7-0.7-0.4-0.6-1.7-1.7-0.20.30.80.9
Stereotopy head waving duration, day 71.72.13.5-1.8-1.8-1.9-1.91.31.2-1.8-1.7-1.7-1.8-1.3-1.3-1.1-1.3-1.6-1.6-1.0-0.30.20.3
Locomotion velocity, session 81.41.72.8-1.5-1.7-1.7-1.61.21.2-1.6-1.4-1.4-1.6-1.2-1.2-0.7-1.4-1.4-1.4-1.2-0.60.30.1
Locomotion distance, session 81.52.23.8-1.8-1.5-1.9-1.91.61.4-1.9-1.9-1.9-1.9-1.4-1.4-1.2-0.8-1.5-1.5-0.90.30.81.1
Degree of sensitization distance0.91.03.10.3-0.10.80.90.00.21.01.11.11.1-0.2-0.2-0.6-0.91.21.2-1.0-1.7-1.5-1.6
Degree of sensitization stereotypy3.13.46.2-2.1-1.9-2.5-2.51.61.4-2.5-2.3-2.3-2.5-1.3-1.3-0.9-0.9-2.5-2.5-0.50.40.70.9
Conditioned locomotion0.20.20.70.20.4-0.0-0.0-0.4-0.5-0.1-0.2-0.2-0.20.50.40.60.6-0.3-0.30.50.80.70.7
Cocaine response after cond. corrected1.11.32.31.51.31.51.5-0.8-0.71.41.41.51.40.80.90.51.01.11.10.80.1-0.9-0.9
Cocaine response after cond. not corrected0.30.30.80.80.80.70.7-0.2-0.10.60.70.60.60.30.40.20.90.20.20.70.4-0.6-0.6
Cocaine response before conditioning1.11.32.5-1.2-1.1-1.5-1.51.11.0-1.6-1.4-1.4-1.6-0.9-0.9-0.3-0.4-1.6-1.6-0.10.40.50.4
Saline control response1.52.03.4-1.5-1.6-1.4-1.31.81.8-1.3-1.2-1.2-1.2-1.8-1.7-1.8-1.4-1.2-1.2-1.4-0.9-0.9-0.9
Bone: connectivity density0.20.30.8-0.5-0.7-0.6-0.6-0.4-0.4-0.5-0.4-0.4-0.50.0-0.10.4-0.8-0.4-0.4-0.4-0.50.90.2
Bone: cortical apparent density1.11.52.81.51.11.51.5-1.2-1.01.51.71.71.51.01.01.00.71.31.30.9-0.3-0.9-1.2
Bone: cortical area0.40.62.1-0.8-0.9-0.4-0.40.80.8-0.2-0.4-0.3-0.1-0.9-1.0-1.2-1.40.20.2-1.5-1.3-0.1-0.1
Bone: cortical porosity0.90.92.0-0.7-0.3-1.1-1.10.70.6-1.3-1.3-1.3-1.3-0.4-0.3-0.20.4-1.4-1.40.41.30.91.1
Bone: cortical porosity0.70.81.7-0.7-0.3-1.0-1.00.60.5-1.2-1.2-1.2-1.2-0.3-0.2-0.10.4-1.3-1.30.41.20.70.9
Bone: cortical thickness0.20.40.60.70.70.80.7-0.6-0.60.70.50.60.70.60.60.40.50.70.70.30.20.60.6
Bone: cortical thickness0.10.10.3-0.2-0.1-0.2-0.20.50.5-0.3-0.4-0.4-0.2-0.2-0.1-0.50.1-0.2-0.2-0.00.30.20.4
Bone: cortical tissue density1.11.52.61.51.21.51.5-1.2-1.11.41.61.61.41.11.11.10.81.21.21.0-0.1-0.8-1.1
Condit. Reinf. active minus inactive responses0.30.31.3-0.3-0.50.10.10.20.30.30.20.20.4-0.4-0.4-0.7-1.00.80.8-1.0-1.1-0.2-0.1
Condit. Reinf. active-inactive response ratio0.70.73.0-0.9-1.2-0.4-0.40.70.7-0.1-0.2-0.2-0.0-0.9-1.0-1.0-1.70.40.4-1.6-1.7-0.2-0.3
Condit. Reinf. active responses0.10.20.70.10.10.50.5-0.2-0.20.60.40.40.60.10.1-0.2-0.30.80.9-0.4-0.5-0.10.1
Condit. Reinf. inactive responses0.20.30.70.60.80.50.5-0.5-0.50.40.30.30.40.60.70.40.80.30.30.60.80.20.4
Incentive salience index mean0.20.20.8-0.3-0.40.10.10.10.10.30.20.20.4-0.2-0.2-0.5-0.80.80.8-0.8-0.9-0.00.1
Condit. Reinf. lever presses0.00.00.2-0.3-0.3-0.1-0.1-0.1-0.10.0-0.0-0.00.00.10.10.0-0.40.30.3-0.2-0.40.30.3
Condit. Reinf. active minus inactive responses5.77.312.1-3.2-3.1-2.8-2.83.53.5-2.6-2.6-2.6-2.4-3.3-3.3-3.4-2.7-2.0-2.0-2.9-1.5-0.8-0.4
Condit. Reinf. active-inactive response ratio0.70.81.7-1.1-0.8-0.9-0.91.31.3-0.9-1.1-1.1-0.8-1.2-1.1-1.3-0.5-0.6-0.5-0.9-0.10.10.4
Condit. Reinf. active responses8.411.719.8-3.9-4.1-3.3-3.34.44.4-3.0-3.0-3.0-2.8-4.3-4.2-4.4-3.7-2.4-2.4-3.8-2.4-1.7-1.3
Condit. Reinf. inactive responses5.26.711.0-2.8-3.2-2.4-2.33.23.3-2.0-1.8-1.8-1.9-3.2-3.1-3.3-3.1-1.7-1.7-2.8-2.3-2.3-2.0
Condit. Reinf. lever presses17.424.135.2-5.8-5.8-5.5-5.55.95.8-5.2-5.0-5.0-5.1-5.7-5.6-5.3-4.7-4.5-4.5-4.5-2.2-1.1-0.8
Condit. Reinf. lever reinforcers received9.212.821.3-4.2-4.3-3.6-3.64.64.6-3.3-3.3-3.3-3.1-4.4-4.3-4.6-3.8-2.6-2.6-3.9-2.3-1.6-1.1
Conditioned reinforcement - actives0.81.42.4-1.3-1.1-1.5-1.51.31.2-1.5-1.5-1.5-1.5-1.0-0.9-0.8-0.6-1.4-1.4-0.70.40.50.7
Conditioned reinforcement - inactives0.20.30.90.60.60.30.3-0.6-0.60.10.30.30.10.70.81.00.9-0.4-0.40.80.80.2-0.2
Conditioned locomotion1.82.35.4-1.2-0.7-1.7-1.81.41.3-2.0-2.0-2.0-2.0-1.1-1.0-0.60.3-2.3-2.3-0.01.60.81.1
Patch foraging indifference point 0 sec4.27.811.8-3.4-3.4-3.3-3.33.02.9-3.1-3.1-3.1-3.0-3.0-3.0-2.7-2.8-2.7-2.7-2.6-1.10.40.3
Patch foraging indifference point AUC0.20.31.4-0.4-0.7-0.1-0.10.30.40.10.10.10.1-0.4-0.4-0.6-1.00.30.3-0.6-1.2-0.5-0.7
Delay disc. indifference point, 0s delay0.80.91.9-1.0-0.9-0.9-0.91.41.4-0.9-0.9-0.9-0.8-1.3-1.3-1.4-0.6-0.7-0.6-0.8-0.2-0.9-0.4
Delay disc. indifference point, 16s delay0.10.10.40.20.20.00.0-0.3-0.3-0.00.10.1-0.10.40.40.50.4-0.0-0.00.60.30.1-0.0
Delay disc. indifference point, 2s delay1.11.21.8-1.2-1.1-1.3-1.31.31.2-1.3-1.2-1.2-1.2-1.3-1.4-1.1-0.6-1.2-1.2-0.8-0.1-0.4-0.1
Delay disc. indifference point, 24s delay0.91.01.61.20.91.11.1-1.1-1.01.21.31.21.11.11.11.00.51.11.11.0-0.0-0.2-0.6
Delay disc. indifference point, 4s delay0.90.93.3-0.6-0.6-0.4-0.41.51.6-0.4-0.4-0.4-0.4-1.4-1.3-1.6-0.4-0.2-0.2-0.9-0.3-1.8-1.2
Delay disc. indifference point, 8s delay0.20.20.5-0.6-0.7-0.7-0.70.30.3-0.6-0.6-0.6-0.6-0.2-0.2-0.1-0.6-0.6-0.6-0.2-0.30.40.2
Indifference point function ln k1.01.83.5-1.3-0.8-1.6-1.71.10.9-1.8-1.8-1.8-1.8-0.9-1.0-0.50.0-1.9-1.9-0.21.21.11.3
Indifference point function log k1.01.83.5-1.3-0.8-1.6-1.71.10.9-1.8-1.8-1.8-1.8-0.9-1.0-0.50.0-1.9-1.9-0.21.21.11.3
Patch foraging total patch changes 0 sec3.66.710.0-3.2-3.1-3.0-3.02.82.7-2.9-2.8-2.8-2.8-2.8-2.8-2.5-2.5-2.5-2.5-2.4-1.10.20.1
Patch foraging total patch changes 12 sec1.41.95.1-1.7-2.0-1.3-1.21.31.4-0.9-1.0-1.0-0.9-1.4-1.4-1.7-2.2-0.5-0.5-1.9-1.9-0.3-0.5
Patch foraging total patch changes 18 sec2.13.26.4-2.1-2.3-1.6-1.62.02.1-1.3-1.4-1.3-1.2-2.2-2.3-2.2-2.5-0.7-0.7-2.5-1.9-0.9-0.8
Patch foraging total patch changes 24 sec0.40.71.8-0.8-0.8-0.5-0.51.21.2-0.5-0.5-0.5-0.4-1.1-1.1-1.3-0.8-0.2-0.2-1.0-0.7-1.0-0.6
Patch foraging total patch changes 6 sec1.52.33.5-1.9-1.8-1.9-1.91.41.3-1.8-1.8-1.8-1.8-1.4-1.4-1.0-1.5-1.6-1.6-1.3-0.51.10.7
Patch foraging time to switch 0 sec2.85.78.82.93.02.62.6-2.8-2.82.42.32.32.32.82.82.72.71.81.82.61.50.50.6
Patch foraging water rate 0 sec2.45.07.4-2.7-2.5-2.5-2.52.72.7-2.4-2.4-2.4-2.4-2.6-2.6-2.5-2.0-1.9-1.9-2.2-0.6-0.3-0.2
Patch foraging water rate 12 sec1.22.53.7-1.8-1.6-1.9-1.91.81.7-1.9-1.9-1.9-1.9-1.8-1.8-1.5-1.0-1.6-1.6-1.40.2-0.20.2
Patch foraging water rate 18 sec0.40.61.2-1.0-0.9-0.8-0.81.01.0-0.8-0.8-0.8-0.8-1.0-1.0-1.0-0.8-0.5-0.5-1.1-0.4-0.2-0.1
Patch foraging water rate 24 sec1.01.42.7-1.1-0.6-1.4-1.40.90.7-1.6-1.7-1.7-1.6-0.7-0.8-0.40.0-1.4-1.4-0.31.21.31.5
Patch foraging water rate 6 sec0.60.81.6-1.0-0.8-1.2-1.20.80.7-1.2-1.2-1.2-1.3-0.7-0.7-0.4-0.4-1.2-1.2-0.40.50.70.6
Seeking ratio, delayed vs. immediate footshock1.92.33.91.92.01.81.8-1.7-1.61.71.61.61.61.61.61.41.71.41.41.30.9-0.10.0
Distance traveled before self-admin0.30.40.80.70.50.70.7-0.9-0.90.70.70.70.70.80.80.70.30.50.50.5-0.10.2-0.0
Distance traveled after self-admin1.31.64.11.41.70.90.9-1.4-1.50.60.70.70.61.51.51.72.00.10.12.01.80.80.8
Extensor digitorum longus weight0.31.14.50.1-0.40.70.8-0.10.11.11.01.01.1-0.2-0.3-0.8-1.41.61.6-1.1-2.1-1.0-1.3
Bone: elastic displacement1.21.32.21.41.51.21.1-1.4-1.51.00.90.90.91.41.31.51.30.80.81.20.91.00.7
Bone: elastic work1.51.94.01.51.51.21.2-1.8-1.91.01.01.00.91.81.82.01.40.70.71.61.01.40.9
Bone: endosteal estimation1.12.46.8-1.7-2.1-1.0-1.01.71.8-0.6-0.7-0.7-0.5-1.8-1.8-2.1-2.6-0.1-0.1-2.4-2.5-1.1-1.1
Bone: endosteal perimeter1.83.88.2-2.2-2.6-1.6-1.62.12.1-1.3-1.2-1.2-1.2-2.3-2.3-2.6-2.9-0.7-0.7-2.7-2.4-1.6-1.3
Epididymis fat weight0.41.43.11.21.31.61.5-0.9-0.91.61.21.31.61.01.10.20.71.71.80.3-0.1-0.10.5
Delta time in closed arm before/after self-admin1.31.22.30.90.41.21.2-0.8-0.71.41.51.51.40.60.60.3-0.41.51.5-0.2-1.3-1.3-1.5
Delta time in open arm before/after self-admin2.42.43.9-1.8-1.9-1.5-1.51.91.9-1.4-1.4-1.4-1.3-1.8-1.8-1.8-1.9-1.0-1.0-2.0-1.2-0.5-0.5
Diff in mean of infusions in LGA sessions4.85.99.33.03.02.82.7-2.7-2.72.52.52.52.42.72.72.52.72.12.12.61.50.20.3
Delay discount exponential model param0.10.10.20.10.20.30.3-0.3-0.30.30.20.20.30.20.10.1-0.00.20.2-0.1-0.10.40.4
Extinction: sum of active levers before priming0.20.21.5-0.0-0.00.20.20.50.50.20.20.20.2-0.5-0.5-0.7-0.10.20.2-0.4-0.3-1.2-0.9
Active lever presses in extinction session 62.92.96.9-1.3-0.7-1.9-2.01.00.8-2.2-2.2-2.2-2.3-0.7-0.7-0.10.7-2.6-2.60.62.01.81.9
Bone: final force0.00.10.3-0.2-0.3-0.2-0.20.10.1-0.2-0.1-0.1-0.2-0.1-0.10.1-0.4-0.4-0.4-0.2-0.30.50.1
Bone: final moment0.10.10.4-0.4-0.6-0.4-0.30.20.2-0.3-0.2-0.2-0.3-0.3-0.3-0.1-0.7-0.4-0.4-0.5-0.60.3-0.0
Food consumed during 24 hour testing period1.72.34.3-1.7-1.8-2.0-1.91.41.4-1.9-1.5-1.6-1.9-1.3-1.3-1.0-1.2-2.1-2.1-1.0-0.5-0.8-0.6
Glucose0.00.10.20.10.30.30.30.10.10.30.10.10.3-0.2-0.2-0.40.10.40.4-0.10.1-0.4-0.1
Heart weight0.71.01.5-1.2-1.1-1.2-1.21.00.9-1.1-1.2-1.2-1.1-1.0-1.0-0.8-1.0-1.0-1.0-0.9-0.30.90.6
Delay discount hyperbolic model param0.10.10.50.30.30.30.3-0.5-0.50.30.20.20.30.40.40.40.10.20.20.10.10.70.6
Intermittent access intake day 1-15 change1.02.04.2-1.5-1.3-1.8-1.81.31.2-1.9-1.7-1.7-1.9-1.2-1.2-0.7-0.5-2.1-2.0-0.50.40.30.4
Intermittent access intake escalation1.12.34.7-1.6-1.5-1.9-1.91.41.3-2.0-1.8-1.9-2.0-1.3-1.3-0.8-0.6-2.2-2.2-0.60.40.30.4
Intermittent access intake escalation 21.21.42.4-1.4-1.3-1.5-1.51.11.0-1.5-1.5-1.5-1.5-1.0-0.9-0.7-0.7-1.5-1.5-0.60.10.40.4
Intermitt. access day 1 inactive lever presses0.72.53.81.91.81.61.6-1.9-1.91.51.61.61.41.91.91.91.71.01.01.90.80.3-0.1
Intermitt. access day 15 inactive lever presses1.12.23.81.71.81.41.4-1.9-1.91.31.31.31.21.91.92.01.80.80.81.81.20.80.6
Intermitt. access escalation Index0.10.20.60.1-0.10.00.0-0.7-0.70.10.20.20.10.60.60.7-0.10.00.00.3-0.20.80.3
Intermittent access day 1 total infusions0.40.60.9-0.9-0.9-1.0-1.00.80.8-0.9-0.9-0.9-0.9-0.8-0.8-0.5-0.8-0.8-0.8-0.7-0.30.10.0
Intermittent access day 15 total infusions1.62.34.5-1.6-1.5-2.0-1.91.51.4-2.0-1.8-1.8-2.0-1.4-1.4-0.8-0.8-2.1-2.1-0.80.20.20.2
Intermittent access terminal intake (last 3 days)1.92.43.9-1.8-1.8-2.0-2.01.61.5-2.0-1.9-1.9-1.9-1.5-1.4-1.0-1.2-1.9-1.9-1.2-0.10.30.3
Intermittent access total infusions1.11.32.0-1.4-1.4-1.4-1.41.31.3-1.3-1.2-1.2-1.3-1.2-1.2-1.0-1.2-1.1-1.1-1.2-0.5-0.0-0.1
Intermittent access day 1 locomotion0.20.20.8-0.4-0.3-0.6-0.60.10.0-0.6-0.6-0.6-0.60.10.10.3-0.1-0.7-0.70.10.20.90.6
Intermittent access day 15 total locomotion1.01.83.6-1.4-1.1-1.7-1.71.31.1-1.8-1.8-1.8-1.8-1.1-1.0-0.6-0.3-1.9-1.9-0.50.70.60.7
Intermittent access total locomotion0.70.81.3-1.1-1.0-1.1-1.11.00.9-1.1-1.1-1.1-1.2-0.8-0.8-0.6-0.6-1.2-1.2-0.7-0.00.20.3
Intermittent access standard deviation0.30.61.3-0.6-0.7-0.2-0.20.91.0-0.1-0.1-0.1-0.0-0.8-0.8-1.0-1.00.20.2-1.1-1.1-1.1-1.0
Left kidney weight0.31.54.3-0.5-0.80.30.40.91.10.60.50.60.8-1.2-1.2-1.8-1.51.21.2-1.8-2.0-2.1-1.6
Right kidney weight0.52.16.2-0.6-1.10.20.31.11.30.60.50.50.7-1.3-1.3-2.1-1.91.21.2-2.1-2.5-2.5-2.0
Cocaine induced anxiety1.11.62.41.31.21.41.4-1.6-1.51.51.41.41.51.51.51.20.71.41.41.0-0.00.50.2
Post-drug Anxiety1.41.42.11.31.11.41.4-1.5-1.41.41.41.41.41.41.41.20.61.31.31.0-0.1-0.0-0.3
Baseline Anxiety0.20.20.4-0.5-0.6-0.5-0.50.50.5-0.4-0.3-0.3-0.4-0.6-0.6-0.4-0.6-0.4-0.4-0.5-0.4-0.5-0.6
Tail length1.04.013.0-0.8-1.50.40.41.61.90.80.80.81.0-1.8-1.8-2.6-2.92.01.9-3.1-3.6-3.0-2.9
Length with tail0.52.37.5-0.7-1.10.30.31.41.60.70.50.50.8-1.5-1.5-2.1-2.11.51.5-2.4-2.7-1.9-1.7
Length without tail0.10.30.60.80.80.80.7-0.3-0.30.70.70.70.70.40.40.30.70.50.50.60.2-0.4-0.3
Times rat made contact with spout0.60.71.80.50.10.80.9-0.6-0.51.01.11.11.00.30.30.1-0.61.11.1-0.6-1.3-1.0-1.3
Lifetime Intake1.31.62.5-1.5-1.5-1.6-1.61.41.3-1.5-1.5-1.5-1.5-1.3-1.2-1.0-1.1-1.3-1.3-1.1-0.30.10.1
Liver weight, left0.61.04.10.40.10.90.90.20.41.01.01.11.1-0.2-0.1-0.8-0.51.31.3-0.5-1.2-2.0-1.9
Liver weight, right2.13.79.21.61.12.32.3-0.6-0.32.52.52.52.60.40.5-0.6-0.12.72.7-0.4-1.7-3.0-2.6
Locomotor activity0.71.01.8-1.3-1.3-1.1-1.11.11.1-1.0-1.0-1.0-0.9-1.2-1.2-1.2-1.2-0.7-0.7-1.3-0.5-0.1-0.1
Locomotor testing distance1.32.45.3-1.8-1.8-1.3-1.31.91.9-1.1-1.2-1.2-1.0-2.0-2.0-2.2-2.0-0.5-0.5-2.3-1.3-0.7-0.4
Locomotor testing rearing0.51.03.2-0.9-1.0-0.3-0.31.11.2-0.1-0.2-0.20.0-1.2-1.1-1.6-1.60.50.6-1.8-1.4-0.8-0.6
Locomotion in novel chamber0.70.91.8-1.0-0.7-1.2-1.20.90.7-1.3-1.3-1.3-1.4-0.5-0.5-0.6-0.1-1.4-1.4-0.20.70.40.5
Locomotion in novel chamber post-restriction2.43.86.8-2.1-1.7-2.4-2.51.91.6-2.6-2.6-2.6-2.6-1.6-1.6-1.3-0.6-2.6-2.6-0.70.91.01.1
Fecal boli incidents, locomotor time 10.40.61.1-0.7-0.6-1.0-1.00.60.5-1.0-1.0-1.0-1.1-0.7-0.8-0.3-0.1-1.1-1.1-0.40.50.60.5
Change in fecal boli incidents, locomotor task0.60.61.10.90.90.80.8-0.8-0.80.70.80.80.71.01.10.80.80.50.51.00.5-0.3-0.2
Time >=10cm from walls, locomotor time 11.71.83.5-1.5-1.1-1.7-1.81.21.0-1.8-1.9-1.9-1.8-1.0-0.9-0.6-0.4-1.7-1.7-0.40.61.11.2
Bouts of movement, locomotor time 10.10.10.2-0.1-0.0-0.1-0.10.50.5-0.2-0.2-0.2-0.2-0.4-0.4-0.50.2-0.1-0.1-0.00.2-0.4-0.2
Total resting periods, locomotor time 10.10.10.40.10.3-0.0-0.00.10.1-0.2-0.1-0.1-0.2-0.0-0.00.00.6-0.1-0.10.40.7-0.00.1
Rest time, locomotor task time 10.30.41.60.80.80.40.4-0.3-0.30.20.40.30.20.60.60.61.3-0.1-0.11.31.1-0.3-0.3
Distance moved, locomotor task time 10.50.73.1-0.8-1.1-0.3-0.30.60.7-0.0-0.2-0.10.0-0.7-0.7-1.0-1.70.50.4-1.7-1.7-0.4-0.4
Vertical activity count, locomotor time 10.41.03.2-1.3-1.4-0.9-0.90.80.8-0.6-0.8-0.8-0.6-0.9-1.0-1.1-1.8-0.3-0.3-1.6-1.50.40.4
Time >=10cm from walls, locomotor time 20.60.92.0-1.0-0.9-0.9-0.91.41.4-0.9-1.0-1.0-0.9-1.3-1.2-1.3-0.5-0.7-0.7-0.8-0.1-0.5-0.2
Bouts of movement, locomotor time 20.50.81.8-0.8-0.8-0.7-0.71.31.3-0.7-0.6-0.6-0.7-1.3-1.3-1.2-0.6-0.4-0.3-0.9-0.4-1.0-0.7
Total resting periods, locomotor time 20.20.41.1-0.5-0.5-0.5-0.51.01.0-0.5-0.5-0.5-0.5-1.0-1.1-0.9-0.3-0.3-0.3-0.6-0.1-0.9-0.6
Rest time, locomotor task time 21.51.93.01.71.61.61.6-1.7-1.61.51.61.61.51.51.41.51.31.21.21.30.4-0.1-0.3
Distance moved, locomotor task time 22.02.34.2-1.8-1.7-1.5-1.52.02.0-1.4-1.5-1.5-1.3-1.8-1.8-2.1-1.5-1.0-1.0-1.8-0.8-0.3-0.0
Vertical activity count, locomotor time 21.11.42.9-1.6-1.6-1.1-1.11.41.4-0.9-1.1-1.1-0.8-1.4-1.4-1.6-1.7-0.5-0.5-1.6-1.2-0.2-0.0
Light reinforcement 10.92.13.51.71.51.81.8-1.5-1.31.81.91.91.81.31.31.01.01.51.51.2-0.0-0.9-0.9
Light reinforcement 20.10.10.40.30.30.10.10.00.00.00.10.10.0-0.00.00.10.6-0.4-0.40.70.4-0.4-0.4
Bone: marrow area1.02.26.3-1.6-2.0-0.9-0.91.51.6-0.5-0.5-0.5-0.4-1.6-1.6-1.9-2.5-0.0-0.0-2.3-2.5-1.2-1.1
Bone: maximum diameter1.93.57.1-2.3-2.5-1.7-1.72.02.0-1.4-1.5-1.5-1.3-2.2-2.3-2.4-2.7-0.9-0.9-2.6-2.1-0.7-0.5
Bone: maximum force0.10.20.8-0.5-0.7-0.6-0.50.00.0-0.4-0.4-0.4-0.4-0.1-0.10.2-0.7-0.6-0.6-0.2-0.50.90.4
Bone: maximum moment0.20.30.9-0.7-0.9-0.7-0.60.20.2-0.5-0.4-0.4-0.5-0.3-0.3-0.1-1.0-0.6-0.6-0.4-0.80.60.1
Mean time between licks in bursts1.84.38.2-2.1-2.6-1.6-1.52.52.7-1.2-1.0-1.0-1.1-2.6-2.6-2.9-2.7-0.8-0.8-2.6-2.5-2.3-2.0
Mean num. licks in bursts2.23.55.5-2.3-2.2-2.3-2.32.01.9-2.2-2.2-2.2-2.1-1.9-2.0-1.6-1.7-1.7-1.7-1.7-0.60.30.6
Cd content in liver0.50.51.80.60.51.01.0-0.5-0.41.10.90.91.10.30.30.1-0.01.31.3-0.1-0.6-0.3-0.1
Co content in liver0.70.82.0-1.0-1.1-0.6-0.61.01.0-0.4-0.5-0.5-0.4-1.1-1.2-1.2-1.30.10.1-1.4-1.1-0.5-0.3
Cu content in liver0.70.84.50.0-0.20.50.50.30.50.70.70.70.8-0.5-0.6-1.2-0.61.01.0-0.9-1.2-2.1-1.6
Fe content in liver0.00.00.10.20.20.20.2-0.2-0.20.10.10.10.10.20.20.00.3-0.1-0.10.30.20.30.1
K content in liver0.30.20.50.40.20.40.4-0.7-0.70.50.60.60.50.60.60.40.10.50.40.4-0.3-0.6-0.5
Mg content in liver0.10.10.1-0.2-0.1-0.3-0.30.10.0-0.3-0.3-0.3-0.3-0.1-0.1-0.10.2-0.3-0.30.20.3-0.20.0
Mn content in liver1.11.23.51.11.30.60.6-1.3-1.40.30.40.40.21.41.41.41.8-0.3-0.31.91.70.70.7
Na content in liver0.70.81.9-0.8-0.7-1.1-1.10.80.7-1.2-1.1-1.1-1.2-0.7-0.7-0.3-0.1-1.4-1.4-0.10.50.20.3
Rb content in liver0.20.21.0-0.6-0.7-0.4-0.40.10.1-0.2-0.3-0.3-0.2-0.2-0.3-0.3-1.00.10.1-0.7-0.80.40.3
Se content in liver5.46.310.43.13.22.62.6-2.8-2.82.32.42.32.22.92.92.83.21.61.63.22.00.60.4
Sr content in liver0.20.20.7-0.4-0.1-0.5-0.50.10.0-0.6-0.6-0.6-0.6-0.1-0.1-0.10.1-0.5-0.5-0.10.60.80.8
Zn content in liver1.71.94.7-1.6-1.6-1.2-1.21.71.7-1.0-1.1-1.0-0.9-1.8-1.9-2.2-1.6-0.5-0.5-1.8-1.2-1.1-0.5
Bone: minimum diameter0.81.57.0-0.7-1.20.10.20.60.70.50.40.40.6-1.1-1.1-1.6-2.21.01.0-2.1-2.7-1.4-1.5
Time in familiar zone, hab. session 10.20.20.60.30.10.40.4-0.3-0.20.50.60.60.50.40.40.2-0.20.50.50.2-0.6-0.8-0.8
Time in novel zone, hab. session 10.00.00.10.10.20.30.30.10.10.30.10.10.3-0.2-0.2-0.2-0.00.30.3-0.4-0.10.20.2
Total zone transitions, hab. session 10.30.41.1-0.4-0.2-0.7-0.7-0.0-0.1-0.8-0.7-0.7-0.9-0.0-0.10.40.2-1.0-1.00.10.81.00.8
Total locomotion distance, hab. session 10.91.32.91.00.71.51.5-0.8-0.71.61.51.51.70.70.70.3-0.01.71.7-0.1-1.0-0.5-0.7
Locomotion velocity, hab. session 10.50.71.70.70.51.11.1-0.6-0.51.21.11.11.30.50.40.2-0.11.31.3-0.2-0.8-0.2-0.3
Time in familiar zone, hab. session 21.11.13.4-1.4-1.6-1.1-1.00.90.9-0.8-0.7-0.7-0.7-1.0-1.1-1.2-1.8-0.4-0.4-1.4-1.5-0.6-0.6
Time in novel zone, hab. session 20.40.42.30.91.20.60.6-0.3-0.30.40.30.30.30.40.40.41.50.10.10.81.40.10.4
Total zone transitions, hab. session 21.31.63.6-1.2-0.9-1.6-1.60.90.7-1.7-1.7-1.7-1.7-0.7-0.7-0.4-0.0-1.9-1.90.00.91.31.4
Total locomotion distance, hab. session 20.30.41.40.3-0.10.70.7-0.4-0.30.90.80.80.90.20.1-0.3-0.50.80.8-0.3-1.2-0.5-0.7
Locomotion velocity, hab. session 20.40.51.50.40.10.80.8-0.4-0.31.00.91.01.10.20.2-0.4-0.41.01.0-0.3-1.2-0.7-0.8
Novel to familiar place preference ratio0.10.10.3-0.2-0.0-0.3-0.30.20.2-0.4-0.4-0.4-0.4-0.2-0.2-0.30.3-0.6-0.60.20.5-0.00.0
Novelty place preference0.10.10.3-0.00.1-0.1-0.20.20.2-0.2-0.3-0.3-0.2-0.2-0.1-0.30.4-0.4-0.40.30.6-0.2-0.0
Time in novel zone, NPP test0.10.10.3-0.2-0.1-0.3-0.40.40.4-0.4-0.5-0.5-0.4-0.3-0.3-0.40.3-0.6-0.50.10.5-0.10.0
Total zone transitions, NPP test0.20.30.9-0.10.0-0.5-0.50.30.2-0.6-0.5-0.5-0.6-0.1-0.00.20.6-1.0-1.00.70.90.30.4
Total locomotion distance, NPP test1.01.42.81.31.21.61.6-0.8-0.71.61.61.61.70.80.90.20.81.41.40.7-0.3-0.9-0.7
Locomotion velocity, NPP test1.42.03.81.71.51.91.9-1.0-0.91.91.81.81.91.11.10.41.11.61.60.9-0.1-0.9-0.7
Intraocular pressure0.81.12.7-0.8-0.4-1.1-1.20.40.2-1.3-1.4-1.4-1.3-0.3-0.40.10.2-1.5-1.5-0.11.11.61.6
Delta distance traveled before/after self-admin0.60.61.6-0.4-0.1-0.8-0.80.40.3-1.0-1.0-1.0-1.0-0.3-0.30.10.6-1.2-1.20.51.30.70.8
Delta ambulatory time before/after self-admin0.60.72.2-0.4-0.0-0.8-0.90.30.2-1.0-1.0-1.0-1.1-0.1-0.10.20.7-1.3-1.30.71.50.91.0
Parametrial fat weight0.20.51.00.80.60.90.9-0.5-0.40.90.90.90.90.30.20.00.20.90.90.0-0.4-0.8-1.0
Pavlov. Cond. lever latency0.70.92.11.21.41.01.0-0.9-0.90.80.70.70.81.01.10.91.40.50.51.21.00.50.6
Pavlov. Cond. magazine entry latency2.43.15.6-2.2-2.4-1.9-1.91.91.8-1.7-1.7-1.7-1.6-2.0-2.1-2.0-2.2-1.2-1.2-2.0-1.4-0.0-0.1
Pavlov. Cond. change in total contacts0.40.50.9-0.9-0.9-0.8-0.80.70.7-0.7-0.7-0.7-0.7-0.7-0.7-0.8-0.7-0.6-0.6-0.6-0.4-0.1-0.1
Pavlov. Cond. index score1.62.14.4-1.9-2.1-1.5-1.51.51.5-1.2-1.2-1.2-1.1-1.6-1.7-1.7-2.1-0.7-0.7-1.8-1.5-0.4-0.4
Pavlov. Cond. latency score1.62.04.1-1.9-2.0-1.5-1.51.41.4-1.3-1.3-1.3-1.2-1.6-1.7-1.6-2.0-0.8-0.8-1.7-1.4-0.2-0.3
Pavlov. Cond. lever contacts0.60.72.0-1.0-1.3-0.8-0.70.70.8-0.5-0.5-0.5-0.5-0.9-0.9-0.9-1.4-0.1-0.1-1.1-1.1-0.5-0.5
Pavlov. Cond. magazine entry number2.43.05.12.22.31.91.8-1.8-1.81.61.71.71.52.02.12.02.11.11.12.01.30.10.1
Pavlov. Cond. intertrial magazine entries1.92.34.21.92.11.81.8-1.3-1.31.61.51.51.61.61.71.21.91.51.51.51.1-0.4-0.1
Pavlov. Cond. lever-magazine prob. diff.1.31.63.7-1.6-1.9-1.3-1.31.21.2-1.1-1.0-1.0-1.0-1.4-1.5-1.4-1.9-0.6-0.6-1.6-1.4-0.4-0.5
Pavlov. Cond. response bias0.70.82.1-1.2-1.4-0.9-0.90.80.8-0.7-0.7-0.7-0.6-1.0-1.1-1.0-1.4-0.4-0.4-1.2-1.1-0.3-0.4
Pavlov. Cond. lever latency18.525.235.76.05.95.85.8-5.9-5.85.65.55.45.45.65.55.24.45.05.04.11.70.40.1
Pavlov. Cond. magazine entry latency5.36.49.9-3.0-2.8-3.2-3.12.72.5-3.1-3.1-3.1-3.1-2.4-2.4-2.0-1.9-2.8-2.8-1.6-0.21.11.1
Pavlov. Cond. change in total contacts10.516.925.3-4.8-4.5-4.7-4.75.04.9-4.6-4.6-4.6-4.5-4.7-4.6-4.5-3.2-4.0-3.9-3.3-0.9-0.20.4
Pavlov. Cond. index score13.918.727.0-5.2-5.0-5.1-5.15.14.9-4.9-4.9-4.9-4.8-4.7-4.6-4.4-3.7-4.3-4.2-3.5-1.20.20.6
Pavlov. Cond. latency score12.616.723.9-4.9-4.6-4.9-4.94.74.6-4.7-4.7-4.7-4.6-4.4-4.3-4.0-3.4-4.2-4.1-3.1-0.90.40.7
Pavlov. Cond. lever contacts17.223.834.1-5.8-5.7-5.7-5.65.85.6-5.4-5.3-5.3-5.3-5.4-5.3-5.0-4.4-4.7-4.7-4.1-1.7-0.30.0
Pavlov. Cond. magazine entry number6.98.513.03.53.13.53.5-3.3-3.13.53.63.63.43.02.92.72.03.03.02.00.1-1.0-1.4
Pavlov. Cond. intertrial magazine entries0.71.04.10.1-0.40.60.60.30.40.80.80.80.8-0.6-0.6-0.9-1.10.90.9-1.2-1.7-2.0-2.0
Pavlov. Cond. lever-magazine prob. diff.12.917.224.8-5.0-4.8-4.9-4.84.94.8-4.7-4.7-4.6-4.6-4.6-4.5-4.3-3.5-4.0-4.0-3.4-1.20.10.4
Pavlov. Cond. response bias17.724.035.0-5.9-5.7-5.7-5.75.75.6-5.5-5.4-5.4-5.3-5.4-5.3-5.0-4.4-4.7-4.7-4.1-1.6-0.00.3
Time in closed arm before self-admin0.71.02.0-0.9-0.5-1.1-1.20.50.4-1.3-1.3-1.3-1.3-0.3-0.3-0.10.1-1.3-1.30.20.91.41.3
Time in closed arm after self-admin0.90.92.11.11.10.80.8-1.3-1.30.60.80.70.51.31.31.51.20.30.31.30.90.40.1
Time in open arm before self-admin1.71.92.91.71.71.71.6-1.5-1.41.61.61.61.61.31.31.21.41.31.31.30.5-0.4-0.1
Time in open arm after self-admin0.60.62.0-0.9-1.0-0.4-0.40.80.9-0.2-0.3-0.3-0.2-0.9-0.9-1.1-1.40.20.2-1.4-1.3-0.5-0.5
Bone: periosteal estimation1.12.36.0-1.6-1.9-1.0-0.91.71.8-0.6-0.7-0.7-0.5-1.8-1.8-2.1-2.4-0.1-0.1-2.4-2.3-0.9-0.8
Bone: periosteal perimeter1.42.46.7-1.8-2.1-1.2-1.11.51.6-0.8-0.8-0.8-0.7-1.8-1.8-2.0-2.6-0.3-0.3-2.4-2.3-1.2-1.1
Bone: post-yield work0.30.41.8-0.8-1.1-0.7-0.70.20.3-0.5-0.4-0.4-0.5-0.5-0.6-0.2-1.3-0.4-0.4-0.9-1.10.4-0.2
Progressive ratio test 1 active lever presses0.20.20.80.30.4-0.1-0.1-0.4-0.5-0.2-0.2-0.2-0.20.50.50.70.7-0.5-0.50.60.90.60.5
Progressive ratio test 1 breakpoint0.20.20.70.20.4-0.1-0.1-0.4-0.5-0.2-0.1-0.2-0.20.50.50.70.6-0.5-0.50.60.80.60.5
Progressive ratio test 1 inactive lever presses0.30.51.60.50.50.20.2-1.0-1.00.20.30.20.11.01.01.20.6-0.1-0.10.90.61.10.7
Progressive ratio test 2 active lever presses0.60.71.1-0.9-0.9-0.9-0.91.11.1-0.8-0.9-0.9-0.8-1.1-1.1-0.9-0.7-0.7-0.7-1.0-0.2-0.3-0.1
Progressive ratio test 2 breakpoint0.60.71.1-1.0-0.9-0.9-0.91.11.1-0.9-0.9-0.9-0.9-1.1-1.0-0.9-0.7-0.7-0.7-1.0-0.2-0.3-0.0
Progressive ratio test 2 inactive lever presses0.10.20.4-0.6-0.5-0.5-0.50.50.5-0.6-0.6-0.6-0.6-0.5-0.5-0.4-0.4-0.4-0.4-0.60.00.30.3
Incentive Sensitization - Responses1.21.72.7-1.5-1.5-1.3-1.31.61.6-1.2-1.2-1.2-1.1-1.6-1.6-1.5-1.4-0.9-0.9-1.6-0.8-0.5-0.2
Incentive Sensitization - Breakpoint1.21.52.4-1.5-1.4-1.3-1.31.51.5-1.2-1.2-1.2-1.1-1.5-1.5-1.5-1.3-0.9-0.9-1.5-0.7-0.4-0.1
Sum of active levers in priming session hrs 5-60.10.10.3-0.00.1-0.1-0.10.50.5-0.2-0.1-0.1-0.1-0.5-0.5-0.40.3-0.2-0.20.20.2-0.6-0.3
Progressive ratio0.30.51.2-0.6-0.5-0.8-0.80.20.1-0.8-0.9-0.9-0.8-0.1-0.1-0.0-0.0-1.1-1.10.20.40.90.8
Food seeking constrained by brief footshock2.12.54.8-1.7-1.8-1.4-1.42.12.2-1.3-1.2-1.2-1.2-2.1-2.0-2.0-1.7-1.0-1.0-1.7-1.2-1.3-1.3
Seeking ratio, punishment vs. effort0.91.23.0-0.8-1.0-0.3-0.31.31.4-0.1-0.1-0.1-0.1-1.4-1.4-1.5-1.50.40.3-1.6-1.6-1.7-1.6
Retroperitoneal fat weight1.98.322.22.21.63.53.6-1.4-1.03.93.63.64.00.90.9-0.6-0.64.74.7-1.0-2.9-3.0-2.8
Reaction time number correct0.30.62.0-0.00.2-0.5-0.5-0.3-0.5-0.7-0.6-0.6-0.70.50.50.70.8-1.0-1.00.81.41.10.9
Reaction time mean minus median0.71.73.2-1.4-1.6-1.1-1.11.71.7-1.0-1.0-1.0-0.9-1.8-1.8-1.7-1.6-0.7-0.7-1.6-1.3-0.8-0.8
Reaction time mean minus median AUC0.71.82.8-1.5-1.6-1.4-1.41.71.6-1.3-1.2-1.2-1.3-1.7-1.7-1.5-1.4-1.2-1.2-1.3-0.9-0.6-0.6
Reaction time num false alarms1.82.54.11.71.51.91.9-1.7-1.62.01.91.92.01.81.91.30.81.81.81.1-0.2-0.1-0.1
Reaction time num false alarms AUC1.11.62.71.41.31.51.5-1.4-1.31.51.51.51.51.61.61.10.91.31.31.10.1-0.1-0.0
Reaction time trials correct on left0.30.62.0-0.00.2-0.5-0.5-0.3-0.5-0.7-0.6-0.6-0.70.50.50.70.8-1.0-1.00.81.41.10.9
Reaction time trials on left0.30.62.1-0.10.2-0.5-0.6-0.3-0.4-0.7-0.6-0.6-0.80.50.50.70.8-1.0-1.00.81.41.00.9
Reaction time mean0.30.52.00.60.30.80.80.10.20.80.90.90.8-0.2-0.1-0.2-0.20.80.8-0.2-1.0-1.2-1.4
Reaction time mean AUC0.50.72.01.00.71.11.1-0.3-0.21.11.21.21.10.20.30.20.31.01.00.2-0.6-1.2-1.4
Median of all reaction times0.60.91.81.10.81.21.2-0.5-0.41.21.31.31.20.40.50.40.41.11.10.4-0.6-1.0-1.3
Reaction time omissions0.20.31.2-0.2-0.20.00.00.80.80.10.10.10.1-0.8-0.7-0.9-0.4-0.0-0.0-0.6-0.7-1.1-0.9
Reaction time false alarm rate1.31.83.31.51.21.71.7-1.2-1.11.81.71.71.81.31.40.80.61.71.70.8-0.5-0.5-0.4
Reaction time premature initiation rate1.72.47.8-1.7-2.1-0.9-0.91.61.7-0.5-0.7-0.6-0.4-1.7-1.7-2.1-2.80.20.2-2.7-2.7-0.4-0.6
Reaction time premature initiations1.01.84.6-1.7-1.9-1.2-1.21.41.4-1.0-1.1-1.1-0.9-1.4-1.4-1.6-2.1-0.5-0.5-2.1-1.60.30.0
Std. dev. reaction times0.61.13.0-0.8-1.0-0.3-0.31.21.3-0.1-0.1-0.1-0.0-1.3-1.3-1.5-1.50.30.3-1.5-1.7-1.3-1.3
Reaction time trials completed0.30.62.1-0.10.2-0.5-0.6-0.3-0.4-0.7-0.6-0.6-0.80.50.50.70.8-1.0-1.00.81.41.00.9
Reaction time trials AUC0.20.41.5-0.10.1-0.5-0.5-0.1-0.2-0.7-0.6-0.6-0.70.30.30.40.7-0.9-0.90.61.20.80.7
Run reversals in cocaine runway, females1.61.65.70.3-0.31.01.1-0.10.11.41.41.41.5-0.1-0.1-0.6-1.51.91.9-1.2-2.4-1.5-1.7
Run reversals in cocaine runway, males0.00.00.40.1-0.1-0.1-0.00.10.1-0.10.10.1-0.1-0.3-0.30.3-0.0-0.2-0.2-0.0-0.1-0.3-0.6
Latency to leave start box in cocaine runway2.22.53.71.91.81.81.8-1.8-1.71.81.91.81.81.71.71.41.41.51.51.70.4-0.3-0.4
Latency to leave start box in cocaine runway, F2.22.54.21.81.52.02.0-1.7-1.62.02.02.02.01.51.51.01.01.71.71.2-0.3-0.8-0.8
Latency to leave start box in cocaine runway, M0.40.31.20.60.70.30.3-0.6-0.60.20.30.20.20.70.70.90.90.10.11.10.90.40.4
Std. dev. time between licks in bursts0.91.33.9-1.0-1.4-0.4-0.41.11.3-0.1-0.1-0.1-0.0-1.1-1.1-1.6-1.80.20.2-1.5-2.0-1.6-1.4
Total sessions with >9 infusions1.61.93.2-1.7-1.7-1.8-1.81.41.3-1.7-1.6-1.6-1.7-1.2-1.1-1.0-1.3-1.6-1.6-1.0-0.30.30.3
Short access day 1 total inactive lever presses0.10.10.70.10.0-0.0-0.00.30.3-0.10.10.1-0.1-0.2-0.2-0.10.1-0.1-0.1-0.20.1-0.8-0.8
Short access day 10 total inactive lever presses0.61.42.31.41.41.21.2-1.5-1.51.11.11.11.11.51.41.51.20.90.91.30.70.70.5
Short access day 1 total infusions2.33.04.6-2.1-2.2-1.9-1.92.12.1-1.8-1.7-1.7-1.8-2.0-1.9-1.8-1.9-1.3-1.3-1.9-1.0-0.7-0.6
Short access day 10 total infusions0.70.91.4-1.2-1.2-1.2-1.11.11.0-1.1-1.0-1.0-1.1-0.8-0.8-0.8-1.0-0.9-0.9-0.8-0.40.10.1
Short access total infusions1.41.82.9-1.6-1.6-1.7-1.71.51.4-1.6-1.6-1.6-1.6-1.2-1.2-1.1-1.2-1.5-1.5-1.0-0.30.10.1
Short access day 1 locomotion2.63.25.6-2.0-1.8-2.3-2.31.61.4-2.4-2.3-2.3-2.4-1.3-1.3-0.9-1.0-2.4-2.4-0.90.31.00.9
Short access day 10 total locomotion0.91.62.4-1.5-1.4-1.5-1.51.51.4-1.5-1.5-1.5-1.4-1.2-1.1-1.2-1.0-1.4-1.4-0.9-0.30.40.4
Short access total locomotion0.91.02.2-1.1-1.0-1.3-1.30.70.6-1.4-1.3-1.3-1.4-0.4-0.3-0.2-0.5-1.5-1.5-0.20.31.00.8
One hour access (0.3 mA shock)1.01.21.9-1.3-1.1-1.3-1.31.21.2-1.2-1.4-1.4-1.2-1.1-1.1-1.0-0.9-0.9-0.9-1.0-0.10.50.6
Compulsive drug intake0.70.82.70.51.00.20.1-0.7-0.9-0.0-0.2-0.2-0.10.90.81.01.4-0.4-0.31.31.61.41.6
One hour access (shock baseline)1.11.72.4-1.5-1.5-1.5-1.51.51.5-1.5-1.5-1.5-1.5-1.4-1.3-1.1-1.2-1.3-1.3-1.2-0.40.0-0.1
Social response proportion0.70.81.41.00.71.11.1-0.6-0.51.11.21.21.10.70.80.50.41.11.10.5-0.4-0.8-0.9
Social responses0.91.22.70.90.61.31.4-0.7-0.51.51.51.51.50.70.80.2-0.11.61.60.0-1.0-1.0-1.1
Social time2.83.86.92.42.62.12.1-2.1-2.11.91.81.81.82.32.31.92.61.31.32.31.70.30.1
Soleus weight0.72.28.30.3-0.51.11.2-0.3-0.01.51.61.61.6-0.1-0.1-0.8-1.72.02.0-1.4-2.9-1.9-2.3
Bone: stiffness0.10.20.40.40.00.30.3-0.6-0.50.40.60.50.40.50.50.6-0.1-0.1-0.10.4-0.50.2-0.4
Tibialis anterior weight0.10.52.0-0.5-0.9-0.2-0.20.50.60.00.00.00.1-0.7-0.7-0.9-1.30.30.3-1.0-1.4-0.6-0.9
Time to tail flick, vehicle, before self-admin0.10.10.6-0.4-0.5-0.2-0.2-0.0-0.0-0.1-0.2-0.2-0.1-0.0-0.1-0.1-0.80.30.3-0.5-0.60.70.5
Time to tail flick, vehicle, after self-admin0.91.22.0-1.4-1.4-1.3-1.31.11.1-1.2-1.2-1.2-1.2-1.1-1.2-1.0-1.2-1.1-1.1-1.1-0.70.30.2
Time to tail flick, test, before self-admin0.50.52.0-0.5-0.8-0.1-0.10.60.70.10.10.10.2-0.7-0.7-0.9-1.30.50.5-1.3-1.4-0.8-0.9
Time to tail flick, test, after self-admin0.40.41.3-0.1-0.20.30.30.50.60.40.30.40.4-0.6-0.5-0.9-0.60.80.8-0.9-1.0-1.2-1.0
Delta time to tail flick, vehicle, before/after SA1.11.12.2-1.1-0.9-1.3-1.31.01.0-1.3-1.3-1.3-1.3-1.0-1.0-0.7-0.4-1.5-1.5-0.50.20.20.3
Delta time to tail flick, test, before/after SA0.40.41.10.80.90.60.6-0.6-0.60.50.50.50.40.70.70.71.00.40.40.90.80.10.2
Tibia length1.64.37.8-2.2-1.7-2.5-2.61.81.6-2.6-2.8-2.8-2.6-1.7-1.8-1.1-0.6-2.4-2.4-0.81.02.02.2
Ambulatory time before self-admin0.50.71.41.01.00.70.7-1.1-1.20.60.70.70.61.11.11.21.00.30.31.10.70.60.5
Ambulatory time after self-admin1.21.55.61.21.60.50.5-1.1-1.20.20.20.20.11.21.21.52.2-0.4-0.42.02.40.91.1
Bone: tissue strength1.21.26.00.30.6-0.2-0.2-0.9-1.1-0.4-0.4-0.5-0.50.90.81.51.1-0.8-0.81.21.52.42.0
Total heroin consumption0.00.00.20.20.10.10.10.00.00.10.20.10.1-0.1-0.10.10.20.00.00.40.1-0.2-0.1
Bone: trabecular number0.71.22.81.00.90.91.0-1.7-1.71.00.90.90.91.51.41.50.40.90.90.70.11.10.6
Bone: trabecular spacing1.01.32.7-1.0-0.7-1.2-1.21.61.6-1.4-1.3-1.3-1.3-1.4-1.4-1.10.0-1.4-1.4-0.50.7-0.30.2
Bone: trabecular thickness0.50.71.90.60.30.90.9-0.6-0.51.01.01.01.10.50.5-0.0-0.41.41.4-0.3-1.0-0.5-0.8
Bone: trabecular tissue density1.01.53.01.41.11.61.6-0.8-0.61.61.71.71.60.80.80.60.51.41.40.6-0.6-1.2-1.3
Water consumed over 24 hours0.71.01.61.10.91.11.1-1.2-1.21.11.21.21.11.21.31.00.61.00.90.6-0.1-0.3-0.4
Number of responses in last shaping day1.21.33.50.80.51.31.3-1.1-0.91.51.41.41.51.01.00.5-0.41.91.9-0.2-1.3-0.0-0.2