Hub : Genes

Wnt11

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 pVTA mRNA stability Wnt11 0.04 0.03 5.1e-03 0.01 0.01 0 0.01 6.5e-02 6.1e-02 1.4e-01 9.5e-02
2 BLA gene expression Wnt11 0.28 0.13 8.8e-13 0.19 0.21 0.19 0.18 2.6e-10 1.7e-11 2.4e-10 1.2e-09
3 BLA alternative polyA XM_006229718.5 0.08 0.06 4.9e-03 0.03 0.04 0.01 0.03 1.6e-02 3.9e-03 5.2e-02 1.2e-02
4 BLA alternative polyA XM_006229718.5 0.08 0.06 3.3e-03 0.03 0.04 0.03 0.03 1.8e-02 2.3e-03 1.6e-02 1.2e-02
5 pVTA alternative polyA NM_080401.1 0.25 0.13 3.5e-14 0.18 0.18 0.18 0.19 2.6e-14 4.5e-14 2.6e-14 4.8e-15
6 pVTA alternative polyA NM_080401.1 0.24 0.12 7.2e-14 0.17 0.17 0.18 0.19 8.1e-14 7.5e-14 2.9e-14 4.4e-15
7 PL alternative polyA XM_006229718.5 0.08 0.05 3.8e-07 0.06 0.07 0.07 0.07 1.3e-06 4.1e-08 5.6e-08 9.3e-08
8 Brain alternative polyA XM_006229718.5 0.09 0.06 6.7e-06 0.05 0.06 0.05 0.05 9.4e-06 5.7e-06 2.9e-05 1.7e-05
9 Brain alternative polyA XM_006229718.5 0.09 0.06 5.8e-06 0.06 0.06 0.05 0.05 7.4e-06 5.2e-06 2.8e-05 2.3e-05
10 PL alternative polyA XM_006229718.5 0.09 0.06 1.4e-07 0.06 0.07 0.07 0.07 5.7e-07 1.7e-08 4.3e-08 3.8e-08
11 pVTA alternative polyA XM_006229718.5 0.23 0.12 6.1e-14 0.17 0.17 0.18 0.19 6.3e-14 6.9e-14 2.9e-14 3.4e-15
12 pVTA alternative polyA XM_006229718.5 0.24 0.12 2.2e-14 0.18 0.18 0.18 0.19 1.4e-14 3.0e-14 2.0e-14 2.1e-15
13 RMTg gene expression Wnt11 0.14 0.1 8.4e-03 0.06 0.04 0.06 0.07 1.4e-02 3.6e-02 1.0e-02 7.5e-03
14 PL gene expression Wnt11 0.13 0.08 1.8e-11 0.09 0.09 0.08 0.08 1.6e-09 4.1e-10 2.1e-09 1.7e-09
15 NAcc alternative polyA XM_006229718.5 0.16 0.08 0.0e+00 0.15 0.16 0.16 0.16 8.5e-22 2.5e-23 2.7e-23 2.0e-23
16 NAcc alternative polyA XM_006229718.5 0.15 0.08 0.0e+00 0.15 0.16 0.16 0.16 9.7e-22 3.5e-23 6.6e-23 2.2e-23
17 IL gene expression Wnt11 0.4 0.17 4.6e-05 0.05 0.06 0.06 0.06 2.6e-02 1.8e-02 1.4e-02 1.6e-02
18 NAcc gene expression Wnt11 0.02 0.01 9.5e-03 0 0.01 0.01 0.01 8.6e-02 1.2e-02 8.5e-03 3.9e-02
19 LHb gene expression Wnt11 0.83 0.11 8.5e-03 0.08 0.03 0 0.04 7.4e-03 8.6e-02 3.3e-01 3.8e-02
20 Adipose alternative TSS XM_006229718.5 0.04 0.03 8.2e-04 0.01 0.01 0.02 0.01 3.9e-02 1.2e-02 4.9e-03 2.5e-02
21 Adipose alternative TSS XM_006229718.5 0.05 0.04 1.6e-04 0.01 0.02 0.02 0.01 1.7e-02 6.2e-03 4.4e-03 1.0e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21
Bone: apparent density0.10.10.30.2-0.00.20.2-0.6-0.60.30.40.40.30.40.30.5-0.40.40.40.30.10.5-0.30.1
Area under the delay curve0.00.10.2-0.2-0.2-0.3-0.30.30.3-0.3-0.2-0.2-0.3-0.2-0.1-0.10.0-0.2-0.2-0.1-0.5-0.10.30.3
BMI with tail0.51.710.10.20.01.11.10.30.41.31.01.01.4-0.3-0.3-1.4-1.02.12.11.23.21.71.30.7
BMI without tail0.63.013.2-0.5-0.80.70.80.91.21.20.80.91.3-1.1-1.0-2.1-2.12.32.42.43.62.91.81.3
Body weight0.73.215.8-0.3-0.70.90.91.01.31.31.01.01.5-1.1-1.0-2.2-1.92.32.32.14.02.92.11.5
Weight adjusted by age0.10.41.4-0.5-0.5-0.0-0.00.60.70.1-0.1-0.10.1-0.8-0.8-0.9-0.80.40.41.01.20.90.2-0.1
Bone surface1.01.95.0-1.7-2.0-1.4-1.41.41.4-1.1-1.1-1.1-1.1-1.6-1.7-1.4-2.2-0.7-0.72.10.21.70.40.8
Bone volume0.40.82.9-1.0-1.3-0.7-0.60.80.9-0.4-0.4-0.4-0.4-1.0-1.0-1.0-1.70.00.01.70.61.50.50.6
Breakpoint value in progressive ratio session0.50.92.21.11.30.70.7-1.1-1.20.60.60.60.51.11.11.21.50.30.3-1.4-0.6-1.3-0.5-0.6
Number of licking bursts1.44.16.72.52.32.62.6-2.2-2.02.52.62.62.52.02.01.61.52.12.1-1.41.4-0.10.70.9
Context. condit. distance diff. score2.42.95.2-2.1-1.7-2.1-2.21.51.3-2.1-2.3-2.3-2.1-1.3-1.4-1.0-1.2-1.6-1.51.1-0.9-0.2-2.0-2.1
Locomotion velocity, session 10.50.52.20.81.00.40.4-0.4-0.50.10.30.20.10.50.50.81.5-0.2-0.2-1.1-1.3-1.50.3-0.0
Locomotion distance, session 10.60.71.4-0.6-0.2-0.9-0.90.80.7-1.1-1.1-1.1-1.1-0.6-0.6-0.50.6-1.2-1.2-0.3-1.1-1.2-0.2-0.5
Locomotion velocity, session 20.10.21.60.10.10.10.10.20.3-0.00.20.10.0-0.2-0.2-0.40.20.10.00.2-0.3-0.01.31.0
Locomotion distance, session 20.10.20.4-0.4-0.2-0.4-0.50.60.5-0.5-0.5-0.5-0.5-0.5-0.5-0.60.1-0.4-0.50.2-0.4-0.40.60.2
Locomotion velocity, session 30.50.52.7-0.6-0.1-0.7-0.70.40.3-0.8-1.0-1.0-0.8-0.3-0.3-0.20.3-0.5-0.50.0-0.6-1.0-1.3-1.7
Locomotion distance, session 30.91.02.0-0.8-0.3-1.1-1.10.70.6-1.2-1.4-1.4-1.3-0.5-0.5-0.30.4-1.1-1.1-0.3-1.2-1.3-1.1-1.4
Stereotopy head waving bouts, day 30.50.61.10.70.50.90.9-0.9-0.70.91.01.01.00.70.70.30.11.01.0-0.40.50.60.70.8
Stereotopy head waving duration, day 30.20.30.4-0.6-0.6-0.6-0.60.40.4-0.6-0.6-0.6-0.6-0.5-0.6-0.4-0.4-0.5-0.50.5-0.60.1-0.1-0.1
Locomotion velocity, session 70.50.62.30.50.80.40.4-0.9-1.00.30.10.10.31.00.90.70.80.50.5-0.60.1-0.8-1.4-1.5
Locomotion distance, session 70.10.10.30.20.40.30.30.20.20.30.10.10.3-0.1-0.0-0.30.30.40.40.10.6-0.10.0-0.2
Stereotopy head waving bouts, day 71.31.52.9-1.4-1.3-1.7-1.70.80.6-1.7-1.6-1.6-1.7-0.7-0.7-0.4-0.6-1.7-1.70.1-1.6-0.3-0.9-0.9
Stereotopy head waving duration, day 71.62.03.5-1.8-1.8-1.9-1.91.31.2-1.8-1.7-1.7-1.8-1.3-1.3-1.1-1.3-1.6-1.61.0-1.20.3-0.3-0.3
Locomotion velocity, session 81.41.62.8-1.5-1.7-1.7-1.61.21.2-1.6-1.4-1.4-1.6-1.2-1.2-0.7-1.4-1.4-1.41.2-1.20.6-0.4-0.0
Locomotion distance, session 81.52.23.8-1.8-1.5-1.9-1.91.61.4-1.9-1.9-1.9-1.9-1.4-1.4-1.2-0.8-1.5-1.50.9-1.0-0.3-0.8-1.1
Degree of sensitization distance1.01.13.30.3-0.10.80.90.00.21.01.11.11.1-0.2-0.2-0.6-0.91.21.21.01.81.71.51.6
Degree of sensitization stereotypy3.03.46.2-2.1-1.9-2.5-2.51.61.4-2.5-2.3-2.3-2.5-1.3-1.3-0.9-0.9-2.5-2.50.5-2.0-0.4-0.8-0.8
Conditioned locomotion0.20.20.70.20.4-0.0-0.0-0.4-0.5-0.1-0.2-0.2-0.20.50.40.60.6-0.3-0.3-0.5-0.7-0.8-0.7-0.7
Cocaine response after cond. corrected0.81.32.31.51.31.51.5-0.8-0.71.41.41.51.40.80.90.51.01.11.1-0.81.1-0.10.90.9
Cocaine response after cond. not corrected0.20.30.80.80.80.70.7-0.2-0.10.60.70.60.60.30.40.20.90.20.2-0.70.3-0.40.60.6
Cocaine response before conditioning1.11.42.8-1.2-1.1-1.5-1.51.11.0-1.6-1.4-1.4-1.6-0.9-0.9-0.3-0.4-1.6-1.60.1-1.7-0.4-0.5-0.4
Saline control response1.41.93.4-1.5-1.6-1.4-1.31.81.8-1.3-1.2-1.2-1.2-1.8-1.7-1.8-1.4-1.2-1.21.4-0.00.90.80.9
Bone: connectivity density0.20.30.7-0.5-0.7-0.6-0.6-0.4-0.4-0.5-0.4-0.4-0.50.0-0.10.4-0.8-0.4-0.40.4-0.70.5-0.9-0.2
Bone: cortical apparent density0.91.52.81.51.11.51.5-1.2-1.01.51.71.71.51.01.01.00.71.31.3-0.90.60.30.91.2
Bone: cortical area0.40.72.3-0.8-0.9-0.4-0.40.80.8-0.2-0.4-0.3-0.1-0.9-1.0-1.2-1.40.20.21.51.51.30.10.0
Bone: cortical porosity0.91.02.0-0.7-0.3-1.1-1.10.70.6-1.3-1.3-1.3-1.3-0.4-0.3-0.20.4-1.4-1.4-0.4-1.3-1.3-0.9-1.1
Bone: cortical porosity0.80.82.0-0.7-0.3-1.0-1.00.60.5-1.2-1.2-1.2-1.2-0.3-0.2-0.10.4-1.3-1.3-0.4-1.4-1.2-0.8-0.9
Bone: cortical thickness0.20.40.90.70.70.80.7-0.6-0.60.70.50.60.70.60.60.40.50.70.7-0.31.0-0.2-0.6-0.6
Bone: cortical thickness0.10.10.3-0.2-0.1-0.2-0.20.50.5-0.3-0.4-0.4-0.2-0.2-0.1-0.50.1-0.2-0.20.00.3-0.3-0.2-0.4
Bone: cortical tissue density0.91.42.61.51.21.51.5-1.2-1.11.41.61.61.41.11.11.10.81.21.2-1.00.40.10.91.1
Condit. Reinf. active minus inactive responses0.30.42.1-0.3-0.50.10.10.20.30.30.20.20.4-0.4-0.4-0.7-1.00.80.81.01.41.10.30.1
Condit. Reinf. active-inactive response ratio0.70.83.0-0.9-1.2-0.4-0.40.70.7-0.1-0.2-0.2-0.0-0.9-1.0-1.0-1.70.40.41.51.31.70.20.3
Condit. Reinf. active responses0.20.21.30.10.10.50.5-0.2-0.20.60.40.40.60.10.1-0.2-0.30.80.90.41.20.50.2-0.1
Condit. Reinf. inactive responses0.20.30.70.60.80.50.5-0.5-0.50.40.30.30.40.60.70.40.80.30.3-0.60.1-0.8-0.2-0.4
Incentive salience index mean0.20.31.7-0.3-0.40.10.10.10.10.30.20.20.4-0.2-0.2-0.5-0.80.80.80.81.30.90.1-0.1
Condit. Reinf. lever presses0.00.00.2-0.3-0.3-0.1-0.1-0.1-0.10.0-0.0-0.00.00.10.10.0-0.40.30.30.20.30.4-0.3-0.3
Condit. Reinf. active minus inactive responses4.57.012.1-3.2-3.1-2.8-2.83.53.5-2.6-2.6-2.6-2.4-3.3-3.3-3.4-2.7-2.0-2.02.90.41.50.70.4
Condit. Reinf. active-inactive response ratio0.50.81.7-1.1-0.8-0.9-0.91.31.3-0.9-1.1-1.1-0.8-1.2-1.1-1.3-0.5-0.6-0.50.90.40.1-0.1-0.5
Condit. Reinf. active responses7.711.119.8-3.9-4.1-3.3-3.34.44.4-3.0-3.0-3.0-2.8-4.3-4.2-4.4-3.7-2.4-2.43.80.62.41.61.3
Condit. Reinf. inactive responses4.36.311.0-2.8-3.2-2.4-2.33.23.3-2.0-1.8-1.8-1.9-3.2-3.1-3.3-3.1-1.7-1.72.80.32.32.22.0
Condit. Reinf. lever presses15.923.035.2-5.8-5.8-5.5-5.55.95.8-5.2-5.0-5.0-5.1-5.7-5.6-5.3-4.7-4.5-4.54.5-1.32.20.90.8
Condit. Reinf. lever reinforcers received8.712.221.3-4.2-4.3-3.6-3.64.64.6-3.3-3.3-3.3-3.1-4.4-4.3-4.6-3.8-2.6-2.63.90.52.31.41.1
Conditioned reinforcement - actives0.31.42.4-1.3-1.1-1.5-1.51.31.2-1.5-1.5-1.5-1.5-1.0-0.9-0.8-0.6-1.4-1.40.7-1.0-0.4-0.6-0.7
Conditioned reinforcement - inactives0.10.31.00.60.60.30.3-0.6-0.60.10.30.30.10.70.81.00.9-0.4-0.4-0.8-1.0-0.8-0.20.2
Conditioned locomotion1.62.45.4-1.2-0.7-1.7-1.81.41.2-2.0-2.0-2.0-2.0-1.1-1.0-0.60.3-2.3-2.30.0-2.0-1.6-0.9-1.1
Patch foraging indifference point 0 sec2.67.411.8-3.4-3.4-3.3-3.33.02.9-3.1-3.1-3.1-3.0-3.0-3.0-2.7-2.8-2.7-2.72.6-0.81.1-0.4-0.3
Patch foraging indifference point AUC0.10.31.4-0.4-0.7-0.1-0.10.30.40.10.10.10.1-0.4-0.4-0.6-1.00.30.30.60.71.20.50.7
Delay disc. indifference point, 0s delay0.80.91.9-1.0-0.9-0.9-0.91.41.4-0.9-0.9-0.9-0.8-1.3-1.3-1.4-0.6-0.7-0.60.8-0.00.20.90.4
Delay disc. indifference point, 16s delay0.10.10.50.20.20.00.0-0.3-0.3-0.00.10.1-0.10.40.40.50.4-0.0-0.0-0.6-0.7-0.3-0.10.0
Delay disc. indifference point, 2s delay1.01.11.8-1.2-1.1-1.3-1.31.31.2-1.3-1.2-1.2-1.2-1.3-1.4-1.1-0.6-1.2-1.20.8-0.70.10.30.2
Delay disc. indifference point, 24s delay0.61.01.61.20.91.11.1-1.1-1.01.21.31.21.11.11.11.00.51.11.1-1.00.40.00.20.6
Delay disc. indifference point, 4s delay0.80.93.0-0.6-0.6-0.4-0.41.51.6-0.4-0.4-0.4-0.4-1.4-1.3-1.6-0.4-0.2-0.20.90.30.31.71.2
Delay disc. indifference point, 8s delay0.10.20.5-0.6-0.7-0.7-0.70.30.3-0.6-0.6-0.6-0.6-0.2-0.2-0.1-0.6-0.6-0.60.2-0.50.3-0.4-0.2
Indifference point function ln k0.61.93.5-1.3-0.8-1.6-1.71.10.9-1.8-1.8-1.8-1.8-0.9-1.0-0.50.0-1.9-1.90.2-1.7-1.2-1.1-1.3
Indifference point function log k0.61.93.5-1.3-0.8-1.6-1.71.10.9-1.8-1.8-1.8-1.8-0.9-1.0-0.50.0-1.9-1.90.2-1.7-1.2-1.1-1.3
Patch foraging total patch changes 0 sec2.26.410.0-3.2-3.1-3.0-3.02.82.7-2.9-2.8-2.8-2.8-2.8-2.8-2.5-2.5-2.5-2.52.4-0.81.1-0.3-0.1
Patch foraging total patch changes 12 sec1.31.85.1-1.7-2.0-1.3-1.21.31.4-0.9-1.0-1.0-0.9-1.4-1.4-1.7-2.2-0.5-0.51.90.81.90.30.5
Patch foraging total patch changes 18 sec1.33.06.4-2.1-2.3-1.6-1.62.02.1-1.3-1.4-1.3-1.2-2.2-2.3-2.2-2.5-0.7-0.72.50.61.90.90.7
Patch foraging total patch changes 24 sec0.20.71.8-0.8-0.8-0.5-0.51.21.2-0.5-0.5-0.5-0.4-1.1-1.1-1.3-0.8-0.2-0.21.00.50.71.00.6
Patch foraging total patch changes 6 sec1.32.23.5-1.9-1.8-1.9-1.91.41.3-1.8-1.8-1.8-1.8-1.4-1.4-1.0-1.5-1.6-1.61.3-0.60.5-1.1-0.7
Patch foraging time to switch 0 sec1.45.48.82.93.02.62.6-2.8-2.82.42.32.32.32.82.82.72.71.81.8-2.60.3-1.5-0.4-0.6
Patch foraging water rate 0 sec1.34.87.4-2.7-2.5-2.5-2.52.72.7-2.4-2.4-2.4-2.4-2.6-2.6-2.5-2.0-1.9-1.92.2-0.60.60.20.2
Patch foraging water rate 12 sec0.62.53.7-1.8-1.6-1.9-1.91.81.7-1.9-1.9-1.9-1.9-1.8-1.8-1.5-1.0-1.6-1.61.4-1.1-0.20.1-0.2
Patch foraging water rate 18 sec0.30.61.2-1.0-0.9-0.8-0.81.01.0-0.8-0.8-0.8-0.8-1.0-1.0-1.0-0.8-0.5-0.51.1-0.10.40.20.1
Patch foraging water rate 24 sec1.01.42.7-1.1-0.6-1.4-1.40.90.7-1.6-1.7-1.7-1.6-0.7-0.8-0.40.0-1.4-1.40.3-1.5-1.2-1.3-1.4
Patch foraging water rate 6 sec0.60.91.6-1.0-0.8-1.2-1.20.80.7-1.2-1.2-1.2-1.3-0.7-0.7-0.4-0.4-1.2-1.20.4-1.1-0.5-0.8-0.6
Seeking ratio, delayed vs. immediate footshock1.52.23.91.92.01.81.8-1.7-1.61.71.61.61.61.61.61.41.71.41.4-1.30.5-0.90.1-0.0
Distance traveled before self-admin0.20.40.80.70.50.70.7-0.9-0.90.70.70.70.70.80.80.70.30.50.5-0.50.20.1-0.20.0
Distance traveled after self-admin0.91.64.11.41.70.90.9-1.4-1.50.60.70.70.61.51.51.72.00.10.1-2.0-1.1-1.8-0.8-0.8
Extensor digitorum longus weight0.31.34.90.1-0.40.70.8-0.10.11.11.01.01.1-0.2-0.3-0.8-1.41.61.61.12.22.11.11.3
Bone: elastic displacement1.01.32.21.41.51.21.1-1.4-1.51.00.90.90.91.41.31.51.30.80.8-1.2-0.0-0.9-0.9-0.7
Bone: elastic work1.41.84.01.51.51.21.2-1.8-1.91.01.01.00.91.81.82.01.40.70.7-1.6-0.4-1.0-1.3-0.9
Bone: endosteal estimation1.02.46.8-1.7-2.1-1.0-1.01.61.8-0.6-0.7-0.7-0.5-1.8-1.8-2.1-2.6-0.1-0.12.41.32.51.21.1
Bone: endosteal perimeter1.53.68.2-2.2-2.6-1.6-1.62.12.1-1.3-1.2-1.2-1.2-2.3-2.3-2.6-2.9-0.7-0.72.70.82.41.51.3
Epididymis fat weight0.31.54.41.21.31.61.5-0.9-0.91.61.21.31.61.01.10.20.71.71.8-0.32.10.10.2-0.5
Delta time in closed arm before/after self-admin1.31.22.30.90.41.21.2-0.8-0.71.41.51.51.40.60.60.3-0.41.51.50.21.21.31.31.5
Delta time in open arm before/after self-admin1.92.23.9-1.8-1.9-1.5-1.51.91.9-1.4-1.4-1.4-1.3-1.8-1.8-1.8-1.9-1.0-1.02.00.11.20.40.5
Diff in mean of infusions in LGA sessions3.15.69.33.03.02.82.7-2.7-2.72.52.52.52.42.72.72.52.72.12.1-2.60.4-1.5-0.1-0.3
Delay discount exponential model param0.00.10.20.10.20.30.3-0.3-0.30.30.20.20.30.20.10.1-0.00.20.20.10.50.1-0.4-0.4
Extinction: sum of active levers before priming0.10.21.4-0.0-0.00.20.20.50.50.20.20.20.2-0.5-0.5-0.7-0.10.20.20.40.50.31.20.9
Active lever presses in extinction session 63.13.17.4-1.3-0.7-1.9-2.01.00.8-2.2-2.2-2.2-2.3-0.7-0.7-0.10.7-2.6-2.6-0.6-2.7-2.0-1.9-1.8
Bone: final force0.00.10.3-0.2-0.3-0.2-0.20.10.1-0.2-0.1-0.1-0.2-0.1-0.10.1-0.4-0.4-0.40.20.20.3-0.5-0.1
Bone: final moment0.10.10.4-0.4-0.6-0.4-0.30.20.2-0.3-0.2-0.2-0.3-0.3-0.3-0.1-0.7-0.4-0.40.50.20.6-0.30.0
Food consumed during 24 hour testing period1.22.44.3-1.7-1.8-2.0-1.91.41.4-1.9-1.5-1.6-1.9-1.3-1.3-1.0-1.2-2.1-2.10.9-2.00.50.60.6
Glucose0.00.10.30.10.30.30.30.10.10.30.10.10.3-0.2-0.2-0.40.10.40.40.10.6-0.10.40.1
Heart weight0.61.01.5-1.2-1.1-1.2-1.21.00.9-1.1-1.2-1.2-1.1-1.0-1.0-0.8-1.0-1.0-1.00.9-0.20.3-0.9-0.6
Delay discount hyperbolic model param0.10.10.40.30.30.30.3-0.5-0.50.30.20.20.30.40.40.40.10.20.2-0.10.3-0.1-0.6-0.6
Intermittent access intake day 1-15 change0.42.04.2-1.5-1.3-1.8-1.81.31.2-1.9-1.7-1.7-1.9-1.2-1.2-0.7-0.5-2.1-2.00.5-1.6-0.4-0.3-0.3
Intermittent access intake escalation0.42.34.7-1.6-1.5-1.9-1.91.41.3-2.0-1.8-1.9-2.0-1.3-1.3-0.8-0.6-2.2-2.20.6-1.7-0.4-0.4-0.3
Intermittent access intake escalation 20.81.42.4-1.4-1.3-1.5-1.51.11.0-1.5-1.5-1.5-1.5-1.0-0.9-0.7-0.7-1.5-1.50.6-1.1-0.1-0.5-0.4
Intermitt. access day 1 inactive lever presses0.22.43.81.91.81.61.6-1.9-1.91.51.61.61.41.91.91.91.71.01.0-1.9-0.2-0.8-0.30.1
Intermitt. access day 15 inactive lever presses0.42.13.81.71.81.41.4-1.9-1.91.31.31.31.21.91.92.01.80.80.8-1.8-0.2-1.2-0.7-0.6
Intermitt. access escalation Index0.10.20.60.1-0.10.00.0-0.7-0.70.10.20.20.10.60.60.7-0.10.00.0-0.3-0.40.2-0.8-0.3
Intermittent access day 1 total infusions0.20.60.9-0.9-0.9-1.0-1.00.80.8-0.9-0.9-0.9-0.9-0.8-0.8-0.5-0.8-0.8-0.80.7-0.60.3-0.1-0.0
Intermittent access day 15 total infusions1.02.34.5-1.6-1.5-2.0-1.91.51.4-2.0-1.8-1.8-2.0-1.4-1.4-0.8-0.8-2.1-2.10.8-1.7-0.2-0.3-0.1
Intermittent access terminal intake (last 3 days)1.42.43.9-1.8-1.8-2.0-2.01.61.5-2.0-1.9-1.9-1.9-1.5-1.4-1.0-1.2-1.9-1.91.2-1.20.1-0.4-0.3
Intermittent access total infusions1.11.32.0-1.4-1.4-1.4-1.41.31.3-1.3-1.2-1.2-1.3-1.2-1.2-1.0-1.2-1.1-1.11.2-0.50.5-0.00.1
Intermittent access day 1 locomotion0.10.20.8-0.4-0.3-0.6-0.60.10.0-0.6-0.6-0.6-0.60.10.10.3-0.1-0.7-0.7-0.1-0.8-0.2-0.9-0.6
Intermittent access day 15 total locomotion0.51.83.6-1.4-1.1-1.7-1.71.31.1-1.8-1.8-1.8-1.8-1.1-1.0-0.6-0.3-1.9-1.90.5-1.6-0.7-0.6-0.7
Intermittent access total locomotion0.70.81.3-1.1-1.0-1.1-1.11.00.9-1.1-1.1-1.1-1.2-0.8-0.8-0.6-0.6-1.2-1.20.7-0.70.0-0.3-0.2
Intermittent access standard deviation0.10.61.3-0.6-0.7-0.2-0.20.91.0-0.1-0.1-0.1-0.0-0.8-0.8-1.0-1.00.20.21.10.81.11.11.0
Left kidney weight0.21.75.3-0.5-0.80.30.40.91.10.60.50.60.8-1.2-1.2-1.8-1.51.21.21.82.32.02.11.6
Right kidney weight0.32.26.3-0.6-1.10.20.31.11.30.60.50.50.7-1.3-1.3-2.1-1.91.21.22.12.42.52.52.0
Cocaine induced anxiety0.61.62.41.31.21.41.4-1.6-1.51.51.41.41.51.51.51.20.71.41.4-1.00.90.0-0.4-0.2
Post-drug Anxiety1.21.42.11.31.11.41.4-1.5-1.41.41.41.41.41.41.41.20.61.31.3-1.00.70.10.10.3
Baseline Anxiety0.10.20.4-0.5-0.6-0.5-0.50.50.5-0.4-0.3-0.3-0.4-0.6-0.6-0.4-0.6-0.4-0.40.5-0.30.40.50.6
Tail length0.84.313.0-0.8-1.50.40.41.51.90.80.80.81.0-1.8-1.8-2.6-2.92.01.93.13.13.63.02.9
Length with tail0.62.68.6-0.7-1.10.30.31.41.60.70.50.50.8-1.5-1.5-2.1-2.11.51.52.42.92.71.91.7
Length without tail0.10.30.60.80.80.80.7-0.3-0.30.70.70.70.70.40.40.30.70.50.5-0.60.5-0.20.40.3
Times rat made contact with spout0.70.71.80.50.10.80.9-0.6-0.51.01.11.11.00.30.30.1-0.61.11.10.60.91.31.11.3
Lifetime Intake1.31.62.5-1.5-1.5-1.6-1.61.41.3-1.5-1.5-1.5-1.5-1.3-1.2-1.0-1.1-1.3-1.31.1-0.80.3-0.2-0.1
Liver weight, left0.61.14.10.40.10.90.90.20.41.01.01.11.1-0.2-0.1-0.8-0.51.31.30.51.61.22.01.9
Liver weight, right2.33.99.51.61.12.32.3-0.6-0.32.52.52.52.60.40.5-0.6-0.12.72.70.42.91.73.12.6
Locomotor activity0.61.01.8-1.3-1.3-1.1-1.11.11.1-1.0-1.0-1.0-0.9-1.2-1.2-1.2-1.2-0.7-0.71.3-0.20.50.10.1
Locomotor testing distance0.92.35.4-1.8-1.8-1.3-1.31.91.9-1.1-1.2-1.2-1.0-2.0-2.0-2.2-2.0-0.5-0.52.30.81.30.70.4
Locomotor testing rearing0.31.03.3-0.9-1.0-0.3-0.31.11.2-0.1-0.2-0.20.0-1.2-1.1-1.6-1.60.50.61.81.61.40.80.5
Locomotion in novel chamber0.71.01.8-1.0-0.7-1.2-1.20.90.7-1.3-1.3-1.3-1.4-0.5-0.5-0.6-0.1-1.4-1.40.2-1.3-0.7-0.4-0.5
Locomotion in novel chamber post-restriction1.33.96.8-2.1-1.7-2.4-2.51.91.6-2.6-2.6-2.6-2.6-1.6-1.6-1.3-0.6-2.6-2.60.7-2.1-0.9-1.1-1.1
Fecal boli incidents, locomotor time 10.20.61.1-0.7-0.6-1.0-1.00.60.5-1.0-1.0-1.0-1.1-0.7-0.8-0.3-0.1-1.1-1.10.4-1.1-0.5-0.6-0.5
Change in fecal boli incidents, locomotor task0.50.61.10.90.90.80.8-0.8-0.80.70.80.80.71.01.10.80.80.50.5-1.0-0.0-0.50.30.2
Time >=10cm from walls, locomotor time 11.51.93.5-1.5-1.1-1.7-1.81.21.0-1.8-1.9-1.9-1.8-1.0-0.9-0.6-0.4-1.7-1.70.4-1.5-0.6-1.2-1.2
Bouts of movement, locomotor time 10.10.10.2-0.1-0.0-0.1-0.10.50.5-0.2-0.2-0.2-0.2-0.4-0.4-0.50.2-0.1-0.10.0-0.2-0.20.40.2
Total resting periods, locomotor time 10.10.10.40.10.3-0.0-0.00.10.1-0.2-0.1-0.1-0.2-0.0-0.00.00.6-0.1-0.1-0.4-0.6-0.7-0.0-0.1
Rest time, locomotor task time 10.30.41.60.80.80.40.4-0.3-0.30.20.40.30.20.60.60.61.3-0.1-0.1-1.3-0.9-1.10.30.3
Distance moved, locomotor task time 10.30.83.1-0.8-1.1-0.3-0.30.60.7-0.0-0.2-0.10.0-0.7-0.7-1.0-1.70.50.41.81.41.70.40.3
Vertical activity count, locomotor time 10.11.03.2-1.3-1.4-0.9-0.90.80.8-0.6-0.8-0.8-0.6-0.9-1.0-1.1-1.8-0.3-0.31.61.01.5-0.4-0.4
Time >=10cm from walls, locomotor time 20.30.92.0-1.0-0.9-0.9-0.91.41.4-0.9-1.0-1.0-0.9-1.3-1.2-1.3-0.5-0.7-0.70.8-0.10.10.40.2
Bouts of movement, locomotor time 20.20.81.8-0.8-0.8-0.7-0.71.31.3-0.7-0.6-0.6-0.7-1.3-1.3-1.2-0.6-0.4-0.30.9-0.00.40.90.7
Total resting periods, locomotor time 20.10.41.1-0.5-0.5-0.5-0.51.01.0-0.5-0.5-0.5-0.5-1.0-1.1-0.9-0.3-0.3-0.30.6-0.10.10.80.6
Rest time, locomotor task time 21.11.83.01.71.61.61.6-1.7-1.61.51.61.61.51.51.41.51.31.21.2-1.30.2-0.40.10.3
Distance moved, locomotor task time 21.72.24.2-1.8-1.7-1.5-1.52.02.0-1.4-1.5-1.5-1.3-1.8-1.8-2.1-1.5-1.0-1.01.80.40.80.3-0.0
Vertical activity count, locomotor time 20.61.42.9-1.6-1.6-1.1-1.11.41.4-0.9-1.1-1.1-0.8-1.4-1.4-1.7-1.7-0.5-0.51.60.91.20.2-0.0
Light reinforcement 10.52.13.51.71.51.81.8-1.5-1.31.81.91.91.81.31.31.01.01.51.5-1.21.10.00.90.9
Light reinforcement 20.00.10.40.30.30.10.10.00.00.00.10.10.0-0.00.00.10.6-0.4-0.4-0.7-0.3-0.40.40.4
Bone: marrow area0.92.26.3-1.6-2.0-0.9-0.91.51.6-0.5-0.5-0.5-0.4-1.6-1.6-1.9-2.5-0.0-0.02.31.42.51.21.1
Bone: maximum diameter1.73.47.1-2.3-2.5-1.7-1.72.02.0-1.4-1.5-1.5-1.3-2.2-2.3-2.4-2.7-0.9-0.92.60.92.10.60.5
Bone: maximum force0.10.20.8-0.5-0.7-0.6-0.50.00.0-0.4-0.4-0.4-0.4-0.1-0.10.2-0.7-0.6-0.60.2-0.10.5-0.9-0.4
Bone: maximum moment0.20.30.9-0.7-0.9-0.7-0.60.20.2-0.5-0.4-0.4-0.5-0.3-0.3-0.1-1.0-0.6-0.60.40.00.8-0.6-0.1
Mean time between licks in bursts0.74.18.2-2.1-2.6-1.6-1.52.52.7-1.2-1.0-1.0-1.1-2.6-2.6-2.9-2.7-0.8-0.82.60.82.52.22.0
Mean num. licks in bursts1.23.35.5-2.3-2.2-2.3-2.32.01.9-2.2-2.2-2.2-2.1-1.9-2.0-1.6-1.7-1.7-1.71.7-1.00.6-0.4-0.5
Cd content in liver0.60.62.50.60.51.01.0-0.5-0.41.10.90.91.10.30.30.0-0.01.31.30.11.60.60.40.1
Co content in liver0.60.82.0-1.0-1.1-0.6-0.61.01.0-0.4-0.5-0.5-0.4-1.1-1.2-1.2-1.30.10.11.40.71.10.50.3
Cu content in liver0.70.94.60.0-0.20.50.50.30.50.70.70.70.8-0.5-0.6-1.2-0.61.01.00.91.41.22.11.6
Fe content in liver0.00.00.10.20.20.20.2-0.2-0.20.10.10.10.10.20.20.00.3-0.1-0.1-0.30.2-0.2-0.3-0.2
K content in liver0.20.20.50.40.20.40.4-0.7-0.70.50.60.60.50.60.60.40.10.50.4-0.4-0.10.30.60.5
Mg content in liver0.10.10.4-0.2-0.1-0.3-0.30.10.0-0.3-0.3-0.3-0.3-0.1-0.1-0.10.2-0.3-0.3-0.2-0.6-0.30.2-0.0
Mn content in liver1.11.23.51.11.30.60.6-1.3-1.40.30.40.40.21.41.41.41.8-0.3-0.3-1.9-1.3-1.7-0.8-0.7
Na content in liver0.70.81.9-0.8-0.7-1.1-1.10.80.7-1.2-1.1-1.1-1.2-0.7-0.7-0.3-0.1-1.4-1.40.1-1.2-0.5-0.3-0.2
Rb content in liver0.20.21.0-0.6-0.7-0.4-0.40.10.1-0.2-0.3-0.3-0.2-0.2-0.3-0.3-1.00.10.10.70.40.8-0.3-0.3
Se content in liver5.16.010.43.13.22.62.6-2.8-2.82.32.42.32.22.92.92.83.21.61.6-3.2-0.1-2.0-0.5-0.5
Sr content in liver0.20.20.7-0.4-0.1-0.5-0.50.10.0-0.6-0.6-0.6-0.6-0.1-0.1-0.10.1-0.5-0.50.1-0.5-0.6-0.8-0.8
Zn content in liver1.61.84.7-1.6-1.6-1.2-1.21.71.7-1.0-1.1-1.0-0.9-1.8-1.9-2.2-1.6-0.5-0.51.80.71.21.10.5
Bone: minimum diameter0.91.77.0-0.7-1.20.10.20.60.70.50.40.40.6-1.1-1.1-1.6-2.21.01.02.12.32.71.41.4
Time in familiar zone, hab. session 10.20.20.60.30.10.40.4-0.3-0.20.50.60.60.50.40.40.2-0.20.50.5-0.20.20.60.80.8
Time in novel zone, hab. session 10.10.10.50.10.20.30.30.10.10.30.10.10.3-0.2-0.2-0.2-0.00.30.30.40.70.1-0.1-0.2
Total zone transitions, hab. session 10.30.51.5-0.4-0.2-0.7-0.7-0.0-0.1-0.8-0.7-0.7-0.9-0.0-0.10.40.2-1.0-1.0-0.2-1.2-0.8-1.0-0.8
Total locomotion distance, hab. session 11.01.43.71.00.71.51.5-0.8-0.71.61.51.51.70.70.70.3-0.01.71.70.11.91.00.60.7
Locomotion velocity, hab. session 10.60.82.60.70.51.11.1-0.6-0.51.21.11.11.30.50.40.2-0.11.31.30.21.60.80.30.3
Time in familiar zone, hab. session 21.01.13.4-1.4-1.6-1.1-1.00.90.9-0.8-0.7-0.7-0.7-1.0-1.1-1.2-1.8-0.4-0.41.40.21.50.60.6
Time in novel zone, hab. session 20.40.42.30.91.20.60.6-0.3-0.30.40.30.30.30.40.40.41.50.10.1-0.8-0.1-1.4-0.1-0.4
Total zone transitions, hab. session 21.31.73.6-1.2-0.9-1.6-1.60.90.7-1.7-1.7-1.7-1.7-0.7-0.7-0.4-0.0-1.9-1.9-0.0-1.3-0.9-1.4-1.4
Total locomotion distance, hab. session 20.40.52.80.3-0.10.70.7-0.4-0.30.90.80.80.90.20.1-0.3-0.50.80.80.31.71.20.60.6
Locomotion velocity, hab. session 20.50.73.30.40.10.80.8-0.4-0.31.00.91.01.10.20.2-0.4-0.41.01.00.31.81.20.80.8
Novel to familiar place preference ratio0.10.10.3-0.2-0.0-0.3-0.30.20.2-0.4-0.4-0.4-0.4-0.2-0.2-0.30.3-0.6-0.6-0.2-0.2-0.5-0.0-0.0
Novelty place preference0.10.10.3-0.00.1-0.1-0.20.20.2-0.2-0.3-0.3-0.2-0.2-0.1-0.30.4-0.4-0.4-0.3-0.2-0.60.10.0
Time in novel zone, NPP test0.10.10.3-0.2-0.1-0.3-0.40.40.4-0.4-0.5-0.5-0.4-0.3-0.3-0.40.3-0.6-0.5-0.1-0.2-0.50.1-0.0
Total zone transitions, NPP test0.20.31.1-0.10.0-0.5-0.50.30.2-0.6-0.5-0.5-0.6-0.1-0.00.20.6-1.0-1.0-0.7-1.0-0.9-0.4-0.4
Total locomotion distance, NPP test1.01.53.01.31.21.61.6-0.8-0.71.61.61.61.70.80.90.20.81.41.4-0.71.70.31.00.7
Locomotion velocity, NPP test1.42.03.81.71.51.91.9-1.0-0.91.91.81.81.91.11.10.41.11.61.6-0.91.80.11.00.7
Intraocular pressure0.71.12.7-0.8-0.4-1.1-1.20.40.2-1.3-1.4-1.4-1.3-0.3-0.40.10.2-1.5-1.50.1-1.2-1.1-1.7-1.6
Delta distance traveled before/after self-admin0.60.72.0-0.4-0.1-0.8-0.80.40.3-1.0-1.0-1.0-1.0-0.3-0.30.10.6-1.2-1.2-0.5-1.4-1.3-0.8-0.8
Delta ambulatory time before/after self-admin0.50.82.3-0.4-0.0-0.8-0.90.30.2-1.0-1.0-1.0-1.1-0.1-0.10.20.7-1.3-1.3-0.7-1.5-1.5-1.0-1.0
Parametrial fat weight0.20.51.00.80.60.90.9-0.5-0.40.90.90.90.90.30.20.00.20.90.9-0.01.00.40.81.0
Pavlov. Cond. lever latency0.70.92.11.21.41.01.0-0.9-0.90.80.70.70.81.01.10.91.40.50.5-1.20.1-1.0-0.5-0.6
Pavlov. Cond. magazine entry latency2.33.05.6-2.2-2.4-1.9-1.91.91.8-1.7-1.7-1.7-1.6-2.0-2.1-2.0-2.2-1.2-1.22.00.21.4-0.00.1
Pavlov. Cond. change in total contacts0.40.50.9-0.9-0.9-0.8-0.80.70.7-0.7-0.7-0.7-0.7-0.7-0.7-0.8-0.7-0.6-0.60.60.00.40.10.1
Pavlov. Cond. index score1.62.04.4-1.9-2.1-1.5-1.51.51.5-1.2-1.2-1.2-1.1-1.6-1.7-1.7-2.1-0.7-0.71.80.31.50.40.4
Pavlov. Cond. latency score1.51.94.1-1.9-2.0-1.5-1.51.41.4-1.3-1.3-1.3-1.2-1.6-1.7-1.6-2.0-0.8-0.81.70.21.40.20.3
Pavlov. Cond. lever contacts0.50.62.0-1.0-1.3-0.8-0.70.70.8-0.5-0.5-0.5-0.5-0.9-0.9-0.9-1.4-0.1-0.11.10.21.10.50.5
Pavlov. Cond. magazine entry number2.22.85.12.22.31.91.8-1.8-1.81.61.71.71.52.02.12.02.11.11.1-2.0-0.3-1.3-0.1-0.1
Pavlov. Cond. intertrial magazine entries1.82.24.21.92.11.81.8-1.3-1.31.61.51.51.61.61.71.21.91.51.5-1.50.4-1.10.40.1
Pavlov. Cond. lever-magazine prob. diff.1.21.53.7-1.6-1.9-1.3-1.31.21.2-1.1-1.0-1.0-1.0-1.4-1.5-1.4-1.9-0.6-0.61.60.21.40.40.5
Pavlov. Cond. response bias0.60.82.1-1.2-1.4-0.9-0.90.80.8-0.7-0.7-0.7-0.6-1.0-1.1-1.0-1.4-0.4-0.41.20.31.10.30.3
Pavlov. Cond. lever latency17.124.135.76.05.95.85.8-5.9-5.85.65.55.45.45.65.55.24.45.05.0-4.11.7-1.7-0.2-0.1
Pavlov. Cond. magazine entry latency4.46.29.9-3.0-2.8-3.2-3.12.72.5-3.1-3.1-3.1-3.1-2.4-2.4-2.0-1.9-2.8-2.81.6-1.30.2-1.2-1.1
Pavlov. Cond. change in total contacts6.616.125.3-4.8-4.5-4.7-4.75.04.9-4.6-4.6-4.6-4.5-4.7-4.6-4.5-3.2-4.0-3.93.3-1.20.9-0.0-0.4
Pavlov. Cond. index score11.417.927.0-5.2-5.0-5.1-5.15.14.9-4.9-4.9-4.9-4.8-4.7-4.6-4.4-3.7-4.3-4.23.5-1.51.2-0.4-0.5
Pavlov. Cond. latency score10.016.023.9-4.9-4.6-4.9-4.94.74.6-4.7-4.7-4.7-4.6-4.4-4.3-4.0-3.4-4.2-4.13.1-1.60.9-0.6-0.7
Pavlov. Cond. lever contacts15.422.734.1-5.8-5.7-5.7-5.65.85.6-5.4-5.3-5.3-5.3-5.4-5.3-5.0-4.4-4.7-4.74.1-1.51.70.10.0
Pavlov. Cond. magazine entry number6.38.213.03.53.13.53.5-3.3-3.13.53.63.63.43.02.92.72.03.03.0-2.01.2-0.11.11.4
Pavlov. Cond. intertrial magazine entries0.51.14.10.1-0.40.60.60.30.40.80.80.80.8-0.6-0.6-0.9-1.10.90.91.21.41.72.02.0
Pavlov. Cond. lever-magazine prob. diff.10.716.524.8-5.0-4.8-4.9-4.84.94.8-4.7-4.7-4.6-4.6-4.6-4.5-4.3-3.5-4.0-4.03.4-1.31.2-0.2-0.4
Pavlov. Cond. response bias16.623.035.0-5.9-5.7-5.7-5.75.75.6-5.5-5.4-5.4-5.3-5.4-5.3-5.0-4.4-4.7-4.74.1-1.51.6-0.2-0.3
Time in closed arm before self-admin0.61.02.1-0.9-0.5-1.1-1.20.60.4-1.3-1.3-1.3-1.3-0.3-0.3-0.10.1-1.3-1.3-0.2-1.2-0.9-1.5-1.3
Time in closed arm after self-admin0.80.92.11.11.10.80.8-1.3-1.30.60.80.70.51.31.31.51.20.30.3-1.3-0.8-0.9-0.4-0.1
Time in open arm before self-admin1.51.82.91.71.71.71.6-1.5-1.41.61.61.61.61.31.31.21.41.31.3-1.30.7-0.50.40.1
Time in open arm after self-admin0.60.72.0-0.9-1.0-0.4-0.40.80.9-0.2-0.3-0.3-0.2-0.9-0.9-1.1-1.40.20.21.41.01.30.50.5
Bone: periosteal estimation1.02.36.0-1.6-1.9-1.0-0.91.71.8-0.6-0.7-0.7-0.5-1.8-1.8-2.1-2.4-0.1-0.12.41.72.30.90.7
Bone: periosteal perimeter1.22.46.7-1.8-2.1-1.2-1.11.51.6-0.8-0.8-0.8-0.7-1.8-1.8-2.0-2.6-0.3-0.32.41.12.31.21.1
Bone: post-yield work0.20.41.8-0.8-1.1-0.7-0.70.20.3-0.5-0.4-0.4-0.5-0.5-0.6-0.2-1.3-0.4-0.40.9-0.11.1-0.40.2
Progressive ratio test 1 active lever presses0.10.30.80.30.4-0.1-0.1-0.4-0.5-0.2-0.2-0.2-0.20.50.50.70.7-0.5-0.5-0.6-0.9-0.9-0.6-0.5
Progressive ratio test 1 breakpoint0.10.20.70.20.4-0.1-0.1-0.4-0.5-0.2-0.1-0.2-0.20.50.50.70.6-0.5-0.5-0.6-0.8-0.8-0.6-0.5
Progressive ratio test 1 inactive lever presses0.20.51.60.50.50.20.2-1.0-1.00.20.30.20.11.01.01.20.6-0.1-0.1-0.9-0.7-0.6-1.0-0.7
Progressive ratio test 2 active lever presses0.50.71.1-0.9-0.9-0.9-0.91.11.1-0.8-0.9-0.9-0.8-1.1-1.1-0.9-0.7-0.7-0.71.0-0.10.20.30.1
Progressive ratio test 2 breakpoint0.50.71.1-1.0-0.9-0.9-0.91.11.1-0.9-0.9-0.9-0.9-1.1-1.0-0.9-0.7-0.7-0.71.0-0.20.20.20.0
Progressive ratio test 2 inactive lever presses0.10.20.4-0.6-0.5-0.5-0.50.50.5-0.6-0.6-0.6-0.6-0.5-0.5-0.4-0.4-0.4-0.40.6-0.2-0.0-0.3-0.3
Incentive Sensitization - Responses0.61.62.7-1.5-1.5-1.3-1.31.61.6-1.2-1.2-1.2-1.1-1.6-1.6-1.5-1.4-0.9-0.91.60.10.80.50.2
Incentive Sensitization - Breakpoint0.61.42.4-1.5-1.4-1.3-1.31.51.5-1.2-1.2-1.2-1.1-1.5-1.5-1.5-1.3-0.9-0.91.50.00.70.40.1
Sum of active levers in priming session hrs 5-60.10.10.3-0.00.1-0.1-0.10.50.5-0.2-0.1-0.1-0.1-0.5-0.5-0.40.3-0.2-0.2-0.2-0.2-0.20.50.3
Progressive ratio0.20.51.2-0.6-0.5-0.8-0.80.20.1-0.8-0.9-0.9-0.8-0.1-0.1-0.0-0.0-1.1-1.1-0.2-0.8-0.4-1.0-0.8
Food seeking constrained by brief footshock1.92.44.8-1.7-1.8-1.4-1.42.12.2-1.3-1.2-1.2-1.2-2.1-2.0-2.0-1.7-1.0-1.01.7-0.01.21.21.3
Seeking ratio, punishment vs. effort0.51.22.9-0.8-1.0-0.3-0.31.31.4-0.1-0.1-0.1-0.1-1.4-1.4-1.5-1.50.40.31.61.01.61.71.6
Retroperitoneal fat weight2.19.327.62.21.63.53.6-1.4-1.03.93.63.64.00.90.9-0.6-0.64.74.71.05.32.93.12.7
Reaction time number correct0.20.72.6-0.00.2-0.5-0.5-0.3-0.5-0.7-0.6-0.6-0.70.50.50.70.8-1.0-1.0-0.8-1.6-1.4-1.1-0.9
Reaction time mean minus median0.31.73.2-1.4-1.6-1.1-1.11.71.7-1.0-1.0-1.0-0.9-1.8-1.8-1.7-1.6-0.7-0.71.60.31.30.80.8
Reaction time mean minus median AUC0.31.72.8-1.5-1.6-1.4-1.41.71.6-1.3-1.2-1.2-1.3-1.7-1.7-1.5-1.4-1.2-1.21.3-0.30.90.50.6
Reaction time num false alarms1.52.54.11.71.51.91.9-1.7-1.62.01.91.92.01.81.91.30.81.81.8-1.11.60.20.20.1
Reaction time num false alarms AUC0.71.62.71.41.31.51.5-1.4-1.31.51.51.51.51.61.61.10.91.31.3-1.10.9-0.10.20.0
Reaction time trials correct on left0.20.72.6-0.00.2-0.5-0.5-0.3-0.5-0.7-0.6-0.6-0.70.50.50.70.8-1.0-1.0-0.8-1.6-1.4-1.1-0.9
Reaction time trials on left0.20.72.7-0.10.2-0.5-0.6-0.3-0.4-0.7-0.6-0.6-0.80.50.50.70.8-1.0-1.0-0.8-1.6-1.4-1.1-0.9
Reaction time mean0.20.52.00.60.30.80.80.10.20.80.90.90.8-0.2-0.1-0.2-0.20.80.80.20.91.01.11.4
Reaction time mean AUC0.30.72.01.00.71.11.1-0.3-0.21.11.21.21.10.20.30.20.31.01.0-0.20.70.61.21.4
Median of all reaction times0.50.91.81.10.81.21.2-0.5-0.41.21.31.31.20.40.50.40.41.11.1-0.40.70.61.01.3
Reaction time omissions0.20.31.1-0.2-0.20.00.00.80.80.10.10.10.1-0.8-0.7-0.9-0.4-0.0-0.00.60.70.71.01.0
Reaction time false alarm rate1.31.83.31.51.21.71.7-1.2-1.11.81.71.71.81.31.40.80.61.71.7-0.81.60.50.60.4
Reaction time premature initiation rate1.62.57.8-1.7-2.1-0.9-0.91.61.7-0.5-0.7-0.6-0.4-1.7-1.7-2.1-2.80.20.22.71.92.70.50.6
Reaction time premature initiations0.61.74.6-1.7-1.9-1.2-1.21.41.4-1.0-1.1-1.1-0.9-1.4-1.4-1.6-2.1-0.5-0.52.10.81.6-0.3-0.0
Std. dev. reaction times0.31.13.0-0.8-1.0-0.3-0.31.21.3-0.1-0.1-0.1-0.0-1.3-1.3-1.5-1.50.30.31.51.21.71.31.3
Reaction time trials completed0.20.72.7-0.10.2-0.5-0.6-0.3-0.4-0.7-0.6-0.6-0.80.50.50.70.8-1.0-1.0-0.8-1.6-1.4-1.1-0.9
Reaction time trials AUC0.10.52.0-0.10.1-0.5-0.5-0.1-0.2-0.7-0.6-0.6-0.70.30.30.40.7-0.9-0.9-0.6-1.4-1.2-0.8-0.7
Run reversals in cocaine runway, females1.61.85.70.3-0.31.01.1-0.10.11.41.41.41.5-0.1-0.1-0.6-1.51.91.91.22.42.41.61.7
Run reversals in cocaine runway, males0.10.10.50.1-0.1-0.1-0.00.10.1-0.10.10.1-0.1-0.3-0.30.3-0.0-0.2-0.20.0-0.70.10.20.7
Latency to leave start box in cocaine runway1.82.43.71.91.81.81.8-1.8-1.71.81.91.81.81.71.71.41.41.51.5-1.70.5-0.40.40.4
Latency to leave start box in cocaine runway, F2.02.54.21.81.52.02.0-1.7-1.62.02.02.02.01.51.51.01.01.71.7-1.21.30.30.80.8
Latency to leave start box in cocaine runway, M0.40.41.20.60.70.30.3-0.6-0.60.20.30.20.20.70.70.90.90.10.1-1.1-0.7-0.9-0.4-0.3
Std. dev. time between licks in bursts0.71.33.9-1.0-1.4-0.4-0.41.11.3-0.1-0.1-0.1-0.0-1.1-1.1-1.6-1.80.20.21.51.12.01.61.4
Total sessions with >9 infusions1.51.83.2-1.7-1.7-1.8-1.81.41.3-1.7-1.6-1.6-1.7-1.2-1.1-1.0-1.3-1.6-1.61.0-0.90.3-0.3-0.3
Short access day 1 total inactive lever presses0.00.10.60.10.0-0.0-0.00.30.3-0.10.10.1-0.1-0.2-0.2-0.10.1-0.1-0.10.2-0.4-0.10.80.8
Short access day 10 total inactive lever presses0.21.42.31.41.41.21.2-1.5-1.51.11.11.11.11.51.41.51.20.90.9-1.30.1-0.7-0.6-0.5
Short access day 1 total infusions1.52.94.6-2.1-2.2-1.9-1.92.12.1-1.8-1.7-1.7-1.8-2.0-1.9-1.8-1.9-1.3-1.31.9-0.51.00.60.6
Short access day 10 total infusions0.50.81.4-1.2-1.2-1.2-1.11.11.0-1.1-1.0-1.0-1.1-0.8-0.8-0.8-1.0-0.9-0.90.8-0.40.4-0.1-0.0
Short access total infusions1.21.82.9-1.6-1.6-1.7-1.71.51.4-1.6-1.6-1.6-1.6-1.2-1.2-1.1-1.2-1.5-1.51.0-0.90.3-0.1-0.1
Short access day 1 locomotion1.93.25.6-2.0-1.8-2.3-2.31.61.4-2.4-2.3-2.3-2.4-1.3-1.3-0.9-1.0-2.4-2.40.9-1.8-0.3-1.1-0.9
Short access day 10 total locomotion0.41.52.4-1.5-1.4-1.5-1.51.51.4-1.5-1.5-1.5-1.4-1.2-1.1-1.2-1.0-1.4-1.40.9-0.50.3-0.4-0.4
Short access total locomotion0.71.12.2-1.1-1.0-1.3-1.30.70.6-1.4-1.3-1.3-1.4-0.4-0.3-0.2-0.5-1.5-1.50.2-1.2-0.3-1.0-0.8
One hour access (0.3 mA shock)1.01.11.9-1.3-1.1-1.3-1.31.21.2-1.2-1.4-1.4-1.2-1.1-1.1-1.0-0.9-0.9-0.91.1-0.30.1-0.5-0.6
Compulsive drug intake0.60.82.70.51.00.20.1-0.7-0.9-0.0-0.2-0.2-0.10.90.81.01.4-0.4-0.3-1.3-0.9-1.6-1.4-1.6
One hour access (shock baseline)0.61.62.4-1.5-1.5-1.5-1.51.51.5-1.5-1.5-1.5-1.5-1.4-1.3-1.1-1.2-1.3-1.31.2-0.70.4-0.10.1
Social response proportion0.60.71.41.00.71.11.1-0.6-0.51.11.21.21.10.70.80.50.41.11.1-0.50.60.40.80.9
Social responses1.01.32.70.90.61.31.4-0.7-0.51.51.51.51.50.70.80.1-0.11.61.6-0.01.61.01.11.1
Social time2.33.66.92.42.62.12.1-2.1-2.11.91.81.81.82.32.31.92.61.31.3-2.30.2-1.7-0.3-0.1
Soleus weight0.82.48.30.3-0.51.11.2-0.3-0.01.51.61.61.6-0.1-0.1-0.8-1.72.02.01.42.62.91.92.2
Bone: stiffness0.10.20.40.40.00.30.3-0.6-0.50.40.60.50.40.50.50.6-0.1-0.1-0.1-0.40.30.5-0.20.4
Tibialis anterior weight0.10.52.0-0.5-0.9-0.2-0.20.50.60.00.00.00.1-0.7-0.7-0.9-1.30.30.31.00.91.40.60.9
Time to tail flick, vehicle, before self-admin0.10.10.6-0.4-0.5-0.2-0.2-0.0-0.0-0.1-0.2-0.2-0.1-0.0-0.1-0.1-0.80.30.30.50.60.6-0.6-0.5
Time to tail flick, vehicle, after self-admin0.61.22.0-1.4-1.4-1.3-1.31.11.1-1.2-1.2-1.2-1.2-1.1-1.2-1.0-1.2-1.1-1.11.1-0.40.7-0.3-0.2
Time to tail flick, test, before self-admin0.50.62.0-0.5-0.8-0.1-0.10.60.70.10.10.10.2-0.7-0.7-0.9-1.30.50.51.31.11.40.80.9
Time to tail flick, test, after self-admin0.50.51.4-0.1-0.20.30.30.50.60.40.30.40.4-0.6-0.5-0.9-0.60.80.80.91.11.01.21.0
Delta time to tail flick, vehicle, before/after SA1.01.12.2-1.1-0.9-1.3-1.31.01.0-1.3-1.3-1.3-1.3-1.0-1.0-0.7-0.4-1.5-1.50.5-1.1-0.2-0.3-0.3
Delta time to tail flick, test, before/after SA0.30.41.10.80.90.60.6-0.6-0.60.50.50.50.40.70.70.71.00.40.4-0.9-0.3-0.8-0.1-0.2
Tibia length1.54.27.8-2.2-1.7-2.5-2.61.81.6-2.6-2.8-2.8-2.6-1.7-1.8-1.1-0.6-2.4-2.40.8-1.6-1.0-2.1-2.2
Ambulatory time before self-admin0.20.71.41.01.00.70.7-1.1-1.20.60.70.70.61.11.11.21.00.30.3-1.1-0.4-0.7-0.6-0.4
Ambulatory time after self-admin0.91.55.61.21.60.50.5-1.1-1.20.20.20.20.11.21.21.52.2-0.4-0.4-2.0-1.6-2.4-1.0-1.0
Bone: tissue strength1.11.25.90.30.6-0.2-0.2-0.9-1.1-0.4-0.4-0.5-0.50.90.81.51.1-0.8-0.8-1.2-1.2-1.5-2.4-2.0
Total heroin consumption0.00.00.20.20.10.10.10.00.00.10.20.10.1-0.1-0.10.10.20.00.0-0.4-0.0-0.10.10.1
Bone: trabecular number0.61.12.81.00.90.91.0-1.7-1.71.00.90.90.91.51.41.50.40.90.9-0.70.2-0.1-1.0-0.6
Bone: trabecular spacing0.91.32.7-1.0-0.7-1.2-1.21.61.6-1.4-1.3-1.3-1.3-1.4-1.4-1.10.0-1.4-1.40.5-1.0-0.70.2-0.2
Bone: trabecular thickness0.50.71.90.60.30.90.9-0.6-0.51.01.01.01.10.50.5-0.0-0.41.41.40.31.31.00.50.7
Bone: trabecular tissue density0.91.53.01.41.11.61.6-0.8-0.61.61.71.71.60.80.80.60.51.41.4-0.61.20.61.21.3
Water consumed over 24 hours0.50.91.61.10.91.11.1-1.2-1.21.11.21.21.11.21.31.00.61.00.9-0.60.20.10.40.4
Number of responses in last shaping day1.11.43.50.80.51.31.3-1.1-0.91.51.41.41.51.01.00.5-0.41.91.90.21.81.30.10.2