Short access day 1 total infusions

Tags: Behavior · Cocaine · Short access

Project: p50_paul_meyer_2020

2 loci · 2 genes with independent associations · 2 total associated genes

Significant Loci

# Chr Start pos End pos # assoc genes # joint models Best TWAS P Best GWAS P Cond GWAS P Joint genes
1 chr7 14449451 15768722 1 1 2.45e-18 3.84e-02 1.00e+00 LOC102551633
2 chr8 33211184 34601262 1 1 2.28e-13 1.41e-01 3.26e-19 Ddx25

Pleiotropic Associations

Trait Chi2 ratio # genes+ # genes++ % genes++ Corr Corr P Genes
BMI with tail 1.62 1 0 0 0 1e+00 Ddx25
BMI without tail 4.08 1 0 0 0 1e+00 Ddx25
Right kidney weight 2.2 1 0 0 0 1e+00 Ddx25
Tail length 6.06 1 0 0 0 1e+00 Ddx25
Length without tail 5.12 1 0 0 0 1e+00 Ddx25
Parametrial fat weight 2.79 1 0 0 0 1e+00 Ddx25
Patch foraging indifference point 0 sec 7.74 1 0 0 0 1e+00 LOC102551633
Patch foraging total patch changes 0 sec 7.23 1 0 0 0 1e+00 LOC102551633
Patch foraging total patch changes 6 sec 5.65 1 0 0 0 1e+00 LOC102551633
Locomotor activity 4.34 2 0 0 0 1e+00 Ddx25 LOC102551633
Locomotor testing distance 4.33 2 0 0 0 1e+00 Ddx25 LOC102551633
Locomotor testing rearing 3.33 1 0 0 0 1e+00 Ddx25
Reaction time mean minus median AUC 3.91 1 0 0 0 1e+00 Ddx25
Reaction time mean 4.79 1 0 0 0 1e+00 Ddx25
Conditioned reinforcement - actives 6.27 1 0 0 0 1e+00 LOC102551633
Conditioned reinforcement - inactives 10.35 2 0 0 0 1e+00 Ddx25 LOC102551633
Conditioned locomotion 53.64 1 1 50 0 1e+00 LOC102551633
Intermittent access intake day 1-15 change 78.98 1 1 50 0 1e+00 Ddx25
Intermittent access intake escalation 41.26 1 1 50 0 1e+00 Ddx25
Intermittent access intake escalation 2 23.26 2 1 50 0 1e+00 Ddx25 LOC102551633
Intermitt. access day 1 inactive lever presses 25.7 1 1 50 0 1e+00 Ddx25
Intermitt. access day 15 inactive lever presses 40.88 1 1 50 0 1e+00 Ddx25
Intermitt. access escalation Index 36.25 2 1 50 0 1e+00 Ddx25 LOC102551633
Intermittent access day 1 total infusions 19.51 1 0 0 0 1e+00 LOC102551633
Intermittent access day 15 total infusions 25.14 2 1 50 0 1e+00 Ddx25 LOC102551633
Intermittent access terminal intake (last 3 days) 51.19 2 2 100 0 1e+00 Ddx25 LOC102551633
Intermittent access total infusions 19.1 2 1 50 0 1e+00 Ddx25 LOC102551633
Intermittent access day 15 total locomotion 32.88 1 1 50 0 1e+00 LOC102551633
Intermittent access total locomotion 12.95 1 0 0 0 1e+00 LOC102551633
Intermittent access standard deviation 15.54 1 0 0 0 1e+00 Ddx25
Cocaine induced anxiety 12.68 1 0 0 0 1e+00 Ddx25
Baseline Anxiety 5.61 1 0 0 0 1e+00 Ddx25
Lifetime Intake 29.35 2 1 50 0 1e+00 Ddx25 LOC102551633
Incentive Sensitization - Responses 13.59 2 0 0 0 1e+00 Ddx25 LOC102551633
Incentive Sensitization - Breakpoint 14.11 2 0 0 0 1e+00 Ddx25 LOC102551633
Progressive ratio test 1 active lever presses 12.89 2 0 0 0 1e+00 Ddx25 LOC102551633
Progressive ratio test 1 breakpoint 21.79 2 1 50 0 1e+00 Ddx25 LOC102551633
Progressive ratio test 1 inactive lever presses 22.06 2 1 50 0 1e+00 Ddx25 LOC102551633
Progressive ratio test 2 active lever presses 15.63 1 0 0 0 1e+00 Ddx25
Progressive ratio test 2 breakpoint 18.9 1 0 0 0 1e+00 Ddx25
Progressive ratio test 2 inactive lever presses 30.23 2 1 50 0 1e+00 Ddx25 LOC102551633
Total sessions with >9 infusions 18.87 1 0 0 0 1e+00 Ddx25
Short access day 1 total inactive lever presses 7.07 1 0 0 0 1e+00 LOC102551633
Short access day 10 total inactive lever presses 17.14 1 0 0 0 1e+00 LOC102551633
Short access day 10 total infusions 31.95 2 2 100 0 1e+00 Ddx25 LOC102551633
Short access total infusions 49.2 2 2 100 0 1e+00 Ddx25 LOC102551633
Short access day 1 locomotion 22.2 1 0 0 0 1e+00 LOC102551633
Short access day 10 total locomotion 11.38 1 0 0 0 1e+00 Ddx25
One hour access (0.3 mA shock) 70.35 1 1 50 0 1e+00 Ddx25
One hour access (shock baseline) 23.24 2 1 50 0 1e+00 Ddx25 LOC102551633
Number of responses in last shaping day 23.83 2 1 50 0 1e+00 Ddx25 LOC102551633
Locomotion distance, session 3 4.8 1 0 0 0 1e+00 LOC102551633
Degree of sensitization distance 11.08 1 0 0 0 1e+00 LOC102551633
Pavlov. Cond. lever latency 5.45 1 0 0 0 1e+00 LOC102551633
Pavlov. Cond. latency score 4.54 1 0 0 0 1e+00 LOC102551633
Pavlov. Cond. lever contacts 5.74 1 0 0 0 1e+00 LOC102551633
Bone: cortical area 7.52 1 0 0 0 1e+00 Ddx25
Bone: cortical thickness 4.39 1 0 0 0 1e+00 Ddx25
Bone: cortical thickness 5.77 1 0 0 0 1e+00 Ddx25
Bone: final force 4.62 2 0 0 0 1e+00 Ddx25 LOC102551633
Bone: final moment 4.16 2 0 0 0 1e+00 Ddx25 LOC102551633
Bone: maximum force 5.29 2 0 0 0 1e+00 Ddx25 LOC102551633
Bone: maximum moment 4.67 2 0 0 0 1e+00 Ddx25 LOC102551633
Bone: minimum diameter 3.6 1 0 0 0 1e+00 Ddx25
Bone: periosteal estimation 3.75 1 0 0 0 1e+00 Ddx25
Bone: stiffness 4.85 2 0 0 0 1e+00 Ddx25 LOC102551633
Bone: trabecular thickness 4.3 1 0 0 0 1e+00 Ddx25
Distance traveled before self-admin 35.02 2 1 50 0 1e+00 Ddx25 LOC102551633
Distance traveled after self-admin 29.34 2 1 50 0 1e+00 Ddx25 LOC102551633
Delta time in closed arm before/after self-admin 6.42 1 0 0 0 1e+00 Ddx25
Extinction: sum of active levers before priming 24.99 2 0 0 0 1e+00 Ddx25 LOC102551633
Active lever presses in extinction session 6 9.49 1 0 0 0 1e+00 Ddx25
Delta distance traveled before/after self-admin 6.76 1 0 0 0 1e+00 Ddx25
Delta ambulatory time before/after self-admin 13.84 2 0 0 0 1e+00 Ddx25 LOC102551633
Time in closed arm after self-admin 7.65 1 0 0 0 1e+00 LOC102551633
Time in open arm before self-admin 28.75 1 1 50 0 1e+00 LOC102551633
Time in open arm after self-admin 5.82 1 0 0 0 1e+00 LOC102551633
Sum of active levers in priming session hrs 5-6 18.99 1 0 0 0 1e+00 LOC102551633
Time to tail flick, vehicle, before self-admin 31.43 2 1 50 0 1e+00 Ddx25 LOC102551633
Time to tail flick, vehicle, after self-admin 51.7 1 1 50 0 1e+00 LOC102551633
Time to tail flick, test, before self-admin 5.88 1 0 0 0 1e+00 Ddx25
Delta time to tail flick, vehicle, before/after SA 122.63 1 1 50 0 1e+00 LOC102551633
Ambulatory time before self-admin 19.83 2 1 50 0 1e+00 Ddx25 LOC102551633
Ambulatory time after self-admin 11.15 2 0 0 0 1e+00 Ddx25 LOC102551633
Total heroin consumption 19.85 2 1 50 0 1e+00 Ddx25 LOC102551633
Seeking ratio, delayed vs. immediate footshock 9.35 1 0 0 0 1e+00 LOC102551633
Run reversals in cocaine runway, males 8.37 1 0 0 0 1e+00 Ddx25
Latency to leave start box in cocaine runway 5.91 1 0 0 0 1e+00 Ddx25
Latency to leave start box in cocaine runway, M 10.76 1 0 0 0 1e+00 Ddx25
Co content in liver 12.69 1 0 0 0 1e+00 LOC102551633
Fe content in liver 7.51 1 0 0 0 1e+00 LOC102551633
K content in liver 11.66 1 0 0 0 1e+00 LOC102551633
Na content in liver 44.6 1 1 50 0 1e+00 LOC102551633
Rb content in liver 16.75 1 0 0 0 1e+00 LOC102551633
Se content in liver 12.37 1 0 0 0 1e+00 LOC102551633
Sr content in liver 9.74 1 0 0 0 1e+00 Ddx25

Associations by panel

Tissue RNA modality # hits % hits/tests Avg chisq
Adipose alternative polyA 0 0 0.99
Adipose alternative TSS 0 0 1.06
Adipose gene expression 1 0 1.04
Adipose isoform ratio 0 0 1.09
Adipose intron excision ratio 0 0 1.16
Adipose mRNA stability 0 0 1.06
BLA alternative polyA 0 0 1.03
BLA alternative TSS 0 0 1.06
BLA gene expression 0 0 1.08
BLA isoform ratio 0 0 1.05
BLA intron excision ratio 0 0 1.04
BLA mRNA stability 0 0 1.06
Brain alternative polyA 0 0 1.07
Brain alternative TSS 0 0 1.01
Brain gene expression 0 0 1.07
Brain isoform ratio 0 0 1.04
Brain intron excision ratio 0 0 1.07
Brain mRNA stability 0 0 1.05
Eye alternative polyA 0 0 1.17
Eye alternative TSS 0 0 1.04
Eye gene expression 0 0 1.1
Eye isoform ratio 0 0 1.02
Eye intron excision ratio 0 0 1.06
Eye mRNA stability 0 0 1.08
IL alternative polyA 0 0 1.15
IL alternative TSS 0 0 0.94
IL gene expression 0 0 1.03
IL isoform ratio 0 0 1.03
IL intron excision ratio 0 0 1.05
IL mRNA stability 0 0 1.1
LHb alternative polyA 0 0 1.1
LHb alternative TSS 0 0 1.09
LHb gene expression 0 0 1.07
LHb isoform ratio 0 0 1.09
LHb intron excision ratio 0 0 1.08
LHb mRNA stability 0 0 1.15
Liver alternative polyA 0 0 1.05
Liver alternative TSS 0 0 1.14
Liver gene expression 0 0 1.08
Liver isoform ratio 0 0 1.07
Liver intron excision ratio 0 0 1.1
Liver mRNA stability 0 0 1.05
NAcc alternative polyA 0 0 1.09
NAcc alternative TSS 0 0 1.02
NAcc gene expression 0 0 1.06
NAcc isoform ratio 0 0 1.08
NAcc intron excision ratio 0 0 1.09
NAcc mRNA stability 0 0 1.07
OFC alternative polyA 0 0 1.14
OFC alternative TSS 0 0 1.08
OFC gene expression 0 0 1.02
OFC isoform ratio 0 0 1.06
OFC intron excision ratio 0 0 1.06
OFC mRNA stability 0 0 1.06
PL alternative polyA 0 0 1.1
PL alternative TSS 0 0 0.99
PL gene expression 0 0 1.06
PL isoform ratio 0 0 1.1
PL intron excision ratio 0 0 1.07
PL mRNA stability 0 0 1.09
pVTA alternative polyA 0 0 1.18
pVTA alternative TSS 0 0 1.07
pVTA gene expression 0 0 1.09
pVTA isoform ratio 0 0 1.13
pVTA intron excision ratio 0 0 1.08
pVTA mRNA stability 0 0 1.09
RMTg alternative polyA 1 0.2 1.16
RMTg alternative TSS 0 0 1.16
RMTg gene expression 0 0 1.09
RMTg isoform ratio 0 0 1.12
RMTg intron excision ratio 0 0 1.17
RMTg mRNA stability 0 0 1.1