Hub : Traits

Short access day 1 total infusions

Tags: Behavior · Cocaine · Short access

Project: p50_paul_meyer_2020

4 significantly associated models · 3 unique genes

Significant Loci

# chr p0 p1 # assoc genes # joint models best TWAS P best SNP P cond SNP P % var exp joint genes
1 10 46789397 48185455 1 1 3.3e-16 0.171 1.0e+00 100 Trim16
2 10 62271668 63667097 1 1 3.7e-08 0.149 4.7e-18 -3510 Eral1
3 11 39057816 40174684 1 1 7.2e-11 0.017 1.0e+00 100 Epha6

p0: physical position of the start of the locus. p1: physical position of the end of the locus. # joint models: number of models selected by step-wise conditional analysis.

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Heart weight 6.1 2 0 0 0.00 1.000 Trim16 Epha6
Liver weight, left 7.8 1 0 0 0.00 1.000 Trim16
Parametrial fat weight 16.6 1 1 33 0.00 1.000 Epha6
Intraocular pressure 22.0 2 1 33 0.00 1.000 Trim16 Epha6
Tibia length 2.4 1 0 0 0.00 1.000 Epha6
Number of licking bursts 19.2 1 0 0 0.00 1.000 Trim16
Food consumed during 24 hour testing period 13.0 3 0 0 0.00 1.000 Trim16 Eral1 Epha6
Times rat made contact with spout 16.4 3 0 0 -0.98 0.022 Trim16 Eral1 Epha6
Mean time between licks in bursts 5.6 1 0 0 0.00 1.000 Eral1
Mean num. licks in bursts 31.3 2 1 33 0.00 1.000 Trim16 Eral1
Std. dev. time between licks in bursts 9.6 2 0 0 0.00 1.000 Trim16 Eral1
Water consumed over 24 hours 18.3 2 1 33 0.00 1.000 Trim16 Epha6
Indifference point 0 sec 7.9 1 0 0 0.00 1.000 Trim16
Delay discounting total patch changes 0 sec 8.5 1 0 0 0.00 1.000 Trim16
Delay discounting total patch changes 12 sec 11.7 1 0 0 0.00 1.000 Epha6
Delay discounting total patch changes 18 sec 24.0 2 1 33 0.00 1.000 Trim16 Epha6
Delay discounting total patch changes 6 sec 9.4 2 0 0 0.00 1.000 Trim16 Epha6
Delay discounting water rate 0 sec 15.1 1 0 0 0.00 1.000 Trim16
Delay discounting water rate 18 sec 10.7 1 0 0 0.00 1.000 Epha6
Delay discounting water rate 6 sec 7.2 1 0 0 0.00 1.000 Trim16
Locomotor activity 6.2 2 0 0 0.00 1.000 Trim16 Epha6
Locomotor testing distance 8.0 1 0 0 0.00 1.000 Epha6
Reaction time number correct 7.5 1 0 0 0.00 1.000 Trim16
Reaction time trials correct on left 7.5 1 0 0 0.00 1.000 Trim16
Reaction time trials on left 6.9 1 0 0 0.00 1.000 Trim16
Reaction time premature initiation rate 7.8 2 0 0 0.00 1.000 Trim16 Epha6
Reaction time premature initiations 5.8 1 0 0 0.00 1.000 Epha6
Reaction time trials completed 6.9 1 0 0 0.00 1.000 Trim16
Reaction time trials AUC 6.0 1 0 0 0.00 1.000 Trim16
Social time 25.9 1 1 33 0.00 1.000 Trim16
Conditioned locomotion 14.7 1 0 0 0.00 1.000 Epha6
Cocaine response after cond. corrected 14.6 1 0 0 0.00 1.000 Trim16
Cocaine response after cond. not corrected 16.0 1 0 0 0.00 1.000 Trim16
Cocaine response before conditioning 6.7 1 0 0 0.00 1.000 Epha6
Condit. Reinf. lever presses 6.5 2 0 0 0.00 1.000 Trim16 Epha6
Pavlov. Cond. lever latency 5.9 1 0 0 0.00 1.000 Epha6
Pavlov. Cond. lever contacts 7.0 1 0 0 0.00 1.000 Epha6
Pavlov. Cond. magazine entry number 6.5 1 0 0 0.00 1.000 Epha6
Conditioned reinforcement - actives 21.1 1 0 0 0.00 1.000 Epha6
Conditioned reinforcement - inactives 27.0 1 1 33 0.00 1.000 Epha6
Intermittent access intake escalation 2 6.5 1 0 0 0.00 1.000 Eral1
Intermitt. access day 1 inactive lever presses 21.2 2 1 33 0.00 1.000 Trim16 Eral1
Intermitt. access day 15 inactive lever presses 19.8 1 0 0 0.00 1.000 Eral1
Intermitt. access escalation Index 27.6 1 0 0 0.00 1.000 Trim16
Intermittent access day 1 total infusions 10.6 1 0 0 0.00 1.000 Epha6
Intermittent access day 15 total infusions 13.7 1 0 0 0.00 1.000 Epha6
Intermittent access terminal intake (last 3 days) 19.4 1 0 0 0.00 1.000 Epha6
Intermittent access total infusions 17.6 1 0 0 0.00 1.000 Epha6
Intermittent access day 1 locomotion 12.8 1 0 0 0.00 1.000 Trim16
Intermittent access total locomotion 8.6 2 0 0 0.00 1.000 Trim16 Eral1
Cocaine induced anxiety 20.8 2 1 33 0.00 1.000 Trim16 Epha6
Post-drug Anxiety 8.2 2 0 0 0.00 1.000 Trim16 Epha6
Baseline Anxiety 22.5 2 1 33 0.00 1.000 Trim16 Epha6
Lifetime Intake 31.6 1 1 33 0.00 1.000 Epha6
Incentive Sensitization - Responses 9.3 1 0 0 0.00 1.000 Epha6
Incentive Sensitization - Breakpoint 8.8 1 0 0 0.00 1.000 Epha6
Progressive ratio test 1 active lever presses 25.4 1 1 33 0.00 1.000 Epha6
Progressive ratio test 1 breakpoint 30.1 1 1 33 0.00 1.000 Epha6
Progressive ratio test 1 inactive lever presses 9.7 2 0 0 0.00 1.000 Trim16 Epha6
Progressive ratio test 2 active lever presses 31.2 1 1 33 0.00 1.000 Epha6
Progressive ratio test 2 breakpoint 24.1 1 1 33 0.00 1.000 Epha6
Progressive ratio test 2 inactive lever presses 29.3 1 1 33 0.00 1.000 Epha6
Total sessions with >9 infusions 15.1 2 0 0 0.00 1.000 Trim16 Epha6
Short access day 1 total inactive lever presses 9.0 2 0 0 0.00 1.000 Trim16 Epha6
Short access total infusions 32.8 2 1 33 0.00 1.000 Eral1 Epha6
Short access day 1 locomotion 28.2 2 1 33 0.00 1.000 Trim16 Eral1
Short access day 10 total locomotion 14.3 1 0 0 0.00 1.000 Trim16
Short access total locomotion 16.9 2 0 0 0.00 1.000 Trim16 Eral1
Compulsive drug intake 11.9 1 0 0 0.00 1.000 Trim16
One hour access (0.3 mA shock) 33.5 1 1 33 0.00 1.000 Epha6
One hour access (shock baseline) 19.6 1 0 0 0.00 1.000 Epha6
Number of responses in last shaping day 25.6 1 1 33 0.00 1.000 Trim16
Locomotion distance, session 1 17.4 2 1 33 0.00 1.000 Trim16 Epha6
Locomotion distance, session 2 15.7 1 0 0 0.00 1.000 Trim16
Stereotopy head waving bouts, day 3 8.9 1 0 0 0.00 1.000 Epha6
Locomotion velocity, session 7 6.8 1 0 0 0.00 1.000 Epha6
Locomotion distance, session 7 12.3 1 0 0 0.00 1.000 Epha6
Stereotopy head waving bouts, day 7 25.4 1 1 33 0.00 1.000 Trim16
Stereotopy head waving duration, day 7 6.5 1 0 0 0.00 1.000 Trim16
Locomotion distance, session 8 5.0 1 0 0 0.00 1.000 Epha6
Degree of sensitization stereotypy 7.4 1 0 0 0.00 1.000 Trim16
Condit. Reinf. active minus inactive responses 9.4 1 0 0 0.00 1.000 Epha6
Condit. Reinf. active-inactive response ratio 8.4 1 0 0 0.00 1.000 Epha6
Condit. Reinf. active responses 7.5 1 0 0 0.00 1.000 Epha6
Incentive salience index mean 8.3 2 0 0 0.00 1.000 Trim16 Epha6
Condit. Reinf. lever presses 8.2 1 0 0 0.00 1.000 Epha6
Time in familiar zone, hab. session 1 9.3 1 0 0 0.00 1.000 Epha6
Time in novel zone, hab. session 1 6.7 1 0 0 0.00 1.000 Epha6
Total zone transitions, hab. session 1 22.8 2 1 33 0.00 1.000 Trim16 Epha6
Total locomotion distance, hab. session 1 21.6 2 1 33 0.00 1.000 Trim16 Epha6
Locomotion velocity, hab. session 1 19.2 2 1 33 0.00 1.000 Trim16 Epha6
Time in familiar zone, hab. session 2 22.8 2 1 33 0.00 1.000 Trim16 Epha6
Time in novel zone, hab. session 2 25.2 1 1 33 0.00 1.000 Epha6
Total zone transitions, hab. session 2 7.4 1 0 0 0.00 1.000 Epha6
Total locomotion distance, hab. session 2 9.3 2 0 0 0.00 1.000 Trim16 Epha6
Locomotion velocity, hab. session 2 8.7 2 0 0 0.00 1.000 Trim16 Epha6
Total locomotion distance, NPP test 4.5 1 0 0 0.00 1.000 Trim16
Pavlov. Cond. lever latency 14.6 1 0 0 0.00 1.000 Epha6
Pavlov. Cond. magazine entry latency 31.3 2 2 67 0.00 1.000 Trim16 Epha6
Pavlov. Cond. change in total contacts 7.3 1 0 0 0.00 1.000 Epha6
Pavlov. Cond. index score 19.8 2 1 33 0.00 1.000 Trim16 Epha6
Pavlov. Cond. latency score 16.9 2 1 33 0.00 1.000 Trim16 Epha6
Pavlov. Cond. lever contacts 20.5 1 1 33 0.00 1.000 Epha6
Pavlov. Cond. magazine entry number 17.9 2 1 33 0.00 1.000 Trim16 Epha6
Pavlov. Cond. intertrial magazine entries 14.4 1 0 0 0.00 1.000 Trim16
Pavlov. Cond. lever-magazine prob. diff. 18.7 2 1 33 0.00 1.000 Trim16 Epha6
Pavlov. Cond. response bias 19.2 2 1 33 0.00 1.000 Trim16 Epha6
Bone surface 4.2 1 0 0 0.00 1.000 Epha6
Bone: connectivity density 4.6 1 0 0 0.00 1.000 Epha6
Bone: cortical apparent density 18.1 1 0 0 0.00 1.000 Trim16
Bone: cortical porosity 21.5 1 0 0 0.00 1.000 Trim16
Bone: cortical porosity 27.4 1 1 33 0.00 1.000 Trim16
Bone: cortical thickness 13.4 1 0 0 0.00 1.000 Epha6
Bone: cortical tissue density 19.6 1 0 0 0.00 1.000 Trim16
Bone: elastic work 5.8 1 0 0 0.00 1.000 Trim16
Bone: endosteal estimation 3.3 1 0 0 0.00 1.000 Epha6
Bone: marrow area 3.0 1 0 0 0.00 1.000 Epha6
Bone: maximum diameter 6.1 1 0 0 0.00 1.000 Epha6
Bone: periosteal perimeter 4.9 1 0 0 0.00 1.000 Epha6
Bone: post-yield work 16.2 1 0 0 0.00 1.000 Trim16
Bone: stiffness 7.0 1 0 0 0.00 1.000 Epha6
Bone: tissue strength 7.4 1 0 0 0.00 1.000 Trim16
Breakpoint value in progressive ratio session 7.3 1 0 0 0.00 1.000 Eral1
Distance traveled before self-admin 58.4 1 1 33 0.00 1.000 Eral1
Distance traveled after self-admin 7.5 1 0 0 0.00 1.000 Eral1
Delta time in open arm before/after self-admin 8.0 1 0 0 0.00 1.000 Eral1
Extinction: sum of active levers before priming 8.2 1 0 0 0.00 1.000 Eral1
Active lever presses in extinction session 6 20.2 1 0 0 0.00 1.000 Eral1
Delta distance traveled before/after self-admin 8.5 1 0 0 0.00 1.000 Eral1
Delta ambulatory time before/after self-admin 37.5 1 1 33 0.00 1.000 Eral1
Time in open arm after self-admin 10.5 1 0 0 0.00 1.000 Eral1
Time to tail flick, vehicle, before self-admin 10.1 1 0 0 0.00 1.000 Eral1
Time to tail flick, test, before self-admin 6.5 1 0 0 0.00 1.000 Epha6
Delta time to tail flick, vehicle, before/after SA 8.0 1 0 0 0.00 1.000 Epha6
Ambulatory time before self-admin 49.1 1 1 33 0.00 1.000 Eral1
Ambulatory time after self-admin 6.6 1 0 0 0.00 1.000 Eral1
Area under the delay curve 26.0 2 1 33 0.00 1.000 Eral1 Epha6
Delay disc. indifference point, 0s delay 11.5 1 0 0 0.00 1.000 Epha6
Delay disc. indifference point, 16s delay 35.2 2 1 33 0.00 1.000 Trim16 Eral1
Delay disc. indifference point, 24s delay 9.5 1 0 0 0.00 1.000 Eral1
Delay disc. indifference point, 4s delay 8.7 2 0 0 0.00 1.000 Eral1 Epha6
Delay disc. indifference point, 8s delay 39.9 2 1 33 0.00 1.000 Eral1 Epha6
Delay discount exponential model param 21.4 2 1 33 0.00 1.000 Eral1 Epha6
Delay discount hyperbolic model param 18.2 2 1 33 0.00 1.000 Eral1 Epha6
Bouts of movement, locomotor time 1 7.9 1 0 0 0.00 1.000 Epha6
Rest time, locomotor task time 1 15.2 1 0 0 0.00 1.000 Eral1
Vertical activity count, locomotor time 1 7.2 1 0 0 0.00 1.000 Epha6
Time >=10cm from walls, locomotor time 2 39.8 1 1 33 0.00 1.000 Eral1
Rest time, locomotor task time 2 5.6 2 0 0 0.00 1.000 Eral1 Epha6
Distance moved, locomotor task time 2 10.0 2 0 0 0.00 1.000 Trim16 Eral1
Vertical activity count, locomotor time 2 8.7 1 0 0 0.00 1.000 Eral1
Seeking ratio, delayed vs. immediate footshock 11.1 1 0 0 0.00 1.000 Epha6
Locomotion in novel chamber post-restriction 14.7 2 0 0 0.00 1.000 Eral1 Epha6
Progressive ratio 27.9 1 1 33 0.00 1.000 Eral1
Food seeking constrained by brief footshock 14.0 1 0 0 0.00 1.000 Eral1
Seeking ratio, punishment vs. effort 10.2 1 0 0 0.00 1.000 Eral1
Run reversals in cocaine runway, females 11.6 1 0 0 0.00 1.000 Trim16
Run reversals in cocaine runway, males 48.1 1 1 33 0.00 1.000 Eral1
Latency to leave start box in cocaine runway 10.1 3 0 0 -0.60 0.401 Trim16 Eral1 Epha6
Latency to leave start box in cocaine runway, F 7.3 1 0 0 0.00 1.000 Trim16
Latency to leave start box in cocaine runway, M 38.5 1 1 33 0.00 1.000 Eral1
Cu content in liver 6.2 1 0 0 0.00 1.000 Trim16
K content in liver 8.3 1 0 0 0.00 1.000 Trim16
Mg content in liver 28.9 1 1 33 0.00 1.000 Trim16
Na content in liver 10.2 1 0 0 0.00 1.000 Epha6
Rb content in liver 24.8 1 1 33 0.00 1.000 Trim16
Se content in liver 14.0 2 0 0 0.00 1.000 Trim16 Epha6

chisq ratio: Average Chi2 statistic for the selected genes in the secondary trait, divided by the average statistic for all genes in the secondary trait. # genes+: Shared significant genes at Bonferroni correction. # genes++: Shared significant genes at transcriptome-wide significance. % genes++: Number of [++] genes as a percentage of primary trait’s total joint genes. corr: Correlation of effect sizes across the [+] genes.

Associations by panel

tissue modality # hits % hits/tests avg chisq
Adipose alternative polyA 0 0.000 1.15
Adipose alternative TSS 0 0.000 1.19
Adipose gene expression 1 0.012 1.07
Adipose isoform ratio 0 0.000 1.06
Adipose intron excision ratio 0 0.000 1.14
Adipose mRNA stability 0 0.000 1.05
BLA alternative polyA 0 0.000 0.97
BLA alternative TSS 0 0.000 1.05
BLA gene expression 0 0.000 1.08
BLA isoform ratio 0 0.000 1.05
BLA intron excision ratio 0 0.000 1.05
BLA mRNA stability 0 0.000 1.09
Brain alternative polyA 0 0.000 0.98
Brain alternative TSS 0 0.000 1.01
Brain gene expression 0 0.000 1.07
Brain isoform ratio 0 0.000 1.09
Brain intron excision ratio 0 0.000 1.03
Brain mRNA stability 0 0.000 1.06
Eye alternative polyA 0 0.000 1.06
Eye alternative TSS 0 0.000 0.94
Eye gene expression 0 0.000 1.15
Eye isoform ratio 0 0.000 1.02
Eye intron excision ratio 0 0.000 0.95
Eye mRNA stability 0 0.000 1.09
IL alternative polyA 0 0.000 0.95
IL alternative TSS 0 0.000 1.03
IL gene expression 0 0.000 1.03
IL isoform ratio 0 0.000 0.98
IL intron excision ratio 0 0.000 1.05
IL mRNA stability 0 0.000 1.12
LHb alternative polyA 0 0.000 0.96
LHb alternative TSS 0 0.000 1.19
LHb gene expression 0 0.000 1.08
LHb isoform ratio 0 0.000 1.04
LHb intron excision ratio 0 0.000 1.09
LHb mRNA stability 0 0.000 1.11
Liver alternative polyA 0 0.000 1.06
Liver alternative TSS 0 0.000 1.06
Liver gene expression 0 0.000 1.08
Liver isoform ratio 0 0.000 1.13
Liver intron excision ratio 0 0.000 1.09
Liver mRNA stability 0 0.000 1.04
NAcc alternative polyA 0 0.000 0.92
NAcc alternative TSS 0 0.000 1.08
NAcc gene expression 0 0.000 1.06
NAcc isoform ratio 0 0.000 1.03
NAcc intron excision ratio 0 0.000 1.10
NAcc mRNA stability 0 0.000 1.10
OFC alternative polyA 0 0.000 1.11
OFC alternative TSS 0 0.000 0.91
OFC gene expression 0 0.000 1.06
OFC isoform ratio 0 0.000 1.07
OFC intron excision ratio 0 0.000 1.04
OFC mRNA stability 0 0.000 1.09
PL alternative polyA 0 0.000 0.98
PL alternative TSS 2 0.170 1.11
PL gene expression 1 0.014 1.08
PL isoform ratio 0 0.000 1.05
PL intron excision ratio 0 0.000 1.07
PL mRNA stability 0 0.000 1.10

avg chisq: Average Chi2 (squared Z-score) across all models in this panel for this trait.