Hub : Traits

Short access day 1 total infusions

Tags: Behavior · Cocaine · Short access

Project: p50_paul_meyer_2020

2 loci · 2 genes with independent associations · 2 total associated genes

Significant Loci

#	Chr	Start pos	End pos	# assoc genes	# joint models	Best TWAS P	Best GWAS P	Cond GWAS P	Joint genes
1	chr7	14449451	15768722	1	1	2.45e-18	3.84e-02	1.00e+00	LOC102551633
2	chr8	33211184	34601262	1	1	2.28e-13	1.41e-01	3.26e-19	Ddx25

Pleiotropic Associations

Trait	Chi2 ratio	# genes+	# genes++	% genes++	Corr	Corr P	Genes
BMI with tail	1.62	1	0	0	0	1e+00	Ddx25
BMI without tail	4.08	1	0	0	0	1e+00	Ddx25
Right kidney weight	2.2	1	0	0	0	1e+00	Ddx25
Tail length	6.06	1	0	0	0	1e+00	Ddx25
Length without tail	5.12	1	0	0	0	1e+00	Ddx25
Parametrial fat weight	2.79	1	0	0	0	1e+00	Ddx25
Patch foraging indifference point 0 sec	7.74	1	0	0	0	1e+00	LOC102551633
Patch foraging total patch changes 0 sec	7.23	1	0	0	0	1e+00	LOC102551633
Patch foraging total patch changes 6 sec	5.65	1	0	0	0	1e+00	LOC102551633
Locomotor activity	4.34	2	0	0	0	1e+00	Ddx25 LOC102551633
Locomotor testing distance	4.33	2	0	0	0	1e+00	Ddx25 LOC102551633
Locomotor testing rearing	3.33	1	0	0	0	1e+00	Ddx25
Reaction time mean minus median AUC	3.91	1	0	0	0	1e+00	Ddx25
Reaction time mean	4.79	1	0	0	0	1e+00	Ddx25
Conditioned reinforcement - actives	6.27	1	0	0	0	1e+00	LOC102551633
Conditioned reinforcement - inactives	10.35	2	0	0	0	1e+00	Ddx25 LOC102551633
Conditioned locomotion	53.64	1	1	50	0	1e+00	LOC102551633
Intermittent access intake day 1-15 change	78.98	1	1	50	0	1e+00	Ddx25
Intermittent access intake escalation	41.26	1	1	50	0	1e+00	Ddx25
Intermittent access intake escalation 2	23.26	2	1	50	0	1e+00	Ddx25 LOC102551633
Intermitt. access day 1 inactive lever presses	25.7	1	1	50	0	1e+00	Ddx25
Intermitt. access day 15 inactive lever presses	40.88	1	1	50	0	1e+00	Ddx25
Intermitt. access escalation Index	36.25	2	1	50	0	1e+00	Ddx25 LOC102551633
Intermittent access day 1 total infusions	19.51	1	0	0	0	1e+00	LOC102551633
Intermittent access day 15 total infusions	25.14	2	1	50	0	1e+00	Ddx25 LOC102551633
Intermittent access terminal intake (last 3 days)	51.19	2	2	100	0	1e+00	Ddx25 LOC102551633
Intermittent access total infusions	19.1	2	1	50	0	1e+00	Ddx25 LOC102551633
Intermittent access day 15 total locomotion	32.88	1	1	50	0	1e+00	LOC102551633
Intermittent access total locomotion	12.95	1	0	0	0	1e+00	LOC102551633
Intermittent access standard deviation	15.54	1	0	0	0	1e+00	Ddx25
Cocaine induced anxiety	12.68	1	0	0	0	1e+00	Ddx25
Baseline Anxiety	5.61	1	0	0	0	1e+00	Ddx25
Lifetime Intake	29.35	2	1	50	0	1e+00	Ddx25 LOC102551633
Incentive Sensitization - Responses	13.59	2	0	0	0	1e+00	Ddx25 LOC102551633
Incentive Sensitization - Breakpoint	14.11	2	0	0	0	1e+00	Ddx25 LOC102551633
Progressive ratio test 1 active lever presses	12.89	2	0	0	0	1e+00	Ddx25 LOC102551633
Progressive ratio test 1 breakpoint	21.79	2	1	50	0	1e+00	Ddx25 LOC102551633
Progressive ratio test 1 inactive lever presses	22.06	2	1	50	0	1e+00	Ddx25 LOC102551633
Progressive ratio test 2 active lever presses	15.63	1	0	0	0	1e+00	Ddx25
Progressive ratio test 2 breakpoint	18.9	1	0	0	0	1e+00	Ddx25
Progressive ratio test 2 inactive lever presses	30.23	2	1	50	0	1e+00	Ddx25 LOC102551633
Total sessions with >9 infusions	18.87	1	0	0	0	1e+00	Ddx25
Short access day 1 total inactive lever presses	7.07	1	0	0	0	1e+00	LOC102551633
Short access day 10 total inactive lever presses	17.14	1	0	0	0	1e+00	LOC102551633
Short access day 10 total infusions	31.95	2	2	100	0	1e+00	Ddx25 LOC102551633
Short access total infusions	49.2	2	2	100	0	1e+00	Ddx25 LOC102551633
Short access day 1 locomotion	22.2	1	0	0	0	1e+00	LOC102551633
Short access day 10 total locomotion	11.38	1	0	0	0	1e+00	Ddx25
One hour access (0.3 mA shock)	70.35	1	1	50	0	1e+00	Ddx25
One hour access (shock baseline)	23.24	2	1	50	0	1e+00	Ddx25 LOC102551633
Number of responses in last shaping day	23.83	2	1	50	0	1e+00	Ddx25 LOC102551633
Locomotion distance, session 3	4.8	1	0	0	0	1e+00	LOC102551633
Degree of sensitization distance	11.08	1	0	0	0	1e+00	LOC102551633
Pavlov. Cond. lever latency	5.45	1	0	0	0	1e+00	LOC102551633
Pavlov. Cond. latency score	4.54	1	0	0	0	1e+00	LOC102551633
Pavlov. Cond. lever contacts	5.74	1	0	0	0	1e+00	LOC102551633
Bone: cortical area	7.52	1	0	0	0	1e+00	Ddx25
Bone: cortical thickness	4.39	1	0	0	0	1e+00	Ddx25
Bone: cortical thickness	5.77	1	0	0	0	1e+00	Ddx25
Bone: final force	4.62	2	0	0	0	1e+00	Ddx25 LOC102551633
Bone: final moment	4.16	2	0	0	0	1e+00	Ddx25 LOC102551633
Bone: maximum force	5.29	2	0	0	0	1e+00	Ddx25 LOC102551633
Bone: maximum moment	4.67	2	0	0	0	1e+00	Ddx25 LOC102551633
Bone: minimum diameter	3.6	1	0	0	0	1e+00	Ddx25
Bone: periosteal estimation	3.75	1	0	0	0	1e+00	Ddx25
Bone: stiffness	4.85	2	0	0	0	1e+00	Ddx25 LOC102551633
Bone: trabecular thickness	4.3	1	0	0	0	1e+00	Ddx25
Distance traveled before self-admin	35.02	2	1	50	0	1e+00	Ddx25 LOC102551633
Distance traveled after self-admin	29.34	2	1	50	0	1e+00	Ddx25 LOC102551633
Delta time in closed arm before/after self-admin	6.42	1	0	0	0	1e+00	Ddx25
Extinction: sum of active levers before priming	24.99	2	0	0	0	1e+00	Ddx25 LOC102551633
Active lever presses in extinction session 6	9.49	1	0	0	0	1e+00	Ddx25
Delta distance traveled before/after self-admin	6.76	1	0	0	0	1e+00	Ddx25
Delta ambulatory time before/after self-admin	13.84	2	0	0	0	1e+00	Ddx25 LOC102551633
Time in closed arm after self-admin	7.65	1	0	0	0	1e+00	LOC102551633
Time in open arm before self-admin	28.75	1	1	50	0	1e+00	LOC102551633
Time in open arm after self-admin	5.82	1	0	0	0	1e+00	LOC102551633
Sum of active levers in priming session hrs 5-6	18.99	1	0	0	0	1e+00	LOC102551633
Time to tail flick, vehicle, before self-admin	31.43	2	1	50	0	1e+00	Ddx25 LOC102551633
Time to tail flick, vehicle, after self-admin	51.7	1	1	50	0	1e+00	LOC102551633
Time to tail flick, test, before self-admin	5.88	1	0	0	0	1e+00	Ddx25
Delta time to tail flick, vehicle, before/after SA	122.63	1	1	50	0	1e+00	LOC102551633
Ambulatory time before self-admin	19.83	2	1	50	0	1e+00	Ddx25 LOC102551633
Ambulatory time after self-admin	11.15	2	0	0	0	1e+00	Ddx25 LOC102551633
Total heroin consumption	19.85	2	1	50	0	1e+00	Ddx25 LOC102551633
Seeking ratio, delayed vs. immediate footshock	9.35	1	0	0	0	1e+00	LOC102551633
Run reversals in cocaine runway, males	8.37	1	0	0	0	1e+00	Ddx25
Latency to leave start box in cocaine runway	5.91	1	0	0	0	1e+00	Ddx25
Latency to leave start box in cocaine runway, M	10.76	1	0	0	0	1e+00	Ddx25
Co content in liver	12.69	1	0	0	0	1e+00	LOC102551633
Fe content in liver	7.51	1	0	0	0	1e+00	LOC102551633
K content in liver	11.66	1	0	0	0	1e+00	LOC102551633
Na content in liver	44.6	1	1	50	0	1e+00	LOC102551633
Rb content in liver	16.75	1	0	0	0	1e+00	LOC102551633
Se content in liver	12.37	1	0	0	0	1e+00	LOC102551633
Sr content in liver	9.74	1	0	0	0	1e+00	Ddx25

Associations by panel

Tissue	RNA modality	# hits	% hits/tests	Avg chisq
Adipose	alternative polyA	0	0	0.99
Adipose	alternative TSS	0	0	1.06
Adipose	gene expression	1	0	1.04
Adipose	isoform ratio	0	0	1.09
Adipose	intron excision ratio	0	0	1.16
Adipose	mRNA stability	0	0	1.06
BLA	alternative polyA	0	0	1.03
BLA	alternative TSS	0	0	1.06
BLA	gene expression	0	0	1.08
BLA	isoform ratio	0	0	1.05
BLA	intron excision ratio	0	0	1.04
BLA	mRNA stability	0	0	1.06
Brain	alternative polyA	0	0	1.07
Brain	alternative TSS	0	0	1.01
Brain	gene expression	0	0	1.07
Brain	isoform ratio	0	0	1.04
Brain	intron excision ratio	0	0	1.07
Brain	mRNA stability	0	0	1.05
Eye	alternative polyA	0	0	1.17
Eye	alternative TSS	0	0	1.04
Eye	gene expression	0	0	1.1
Eye	isoform ratio	0	0	1.02
Eye	intron excision ratio	0	0	1.06
Eye	mRNA stability	0	0	1.08
IL	alternative polyA	0	0	1.15
IL	alternative TSS	0	0	0.94
IL	gene expression	0	0	1.03
IL	isoform ratio	0	0	1.03
IL	intron excision ratio	0	0	1.05
IL	mRNA stability	0	0	1.1
LHb	alternative polyA	0	0	1.1
LHb	alternative TSS	0	0	1.09
LHb	gene expression	0	0	1.07
LHb	isoform ratio	0	0	1.09
LHb	intron excision ratio	0	0	1.08
LHb	mRNA stability	0	0	1.15
Liver	alternative polyA	0	0	1.05
Liver	alternative TSS	0	0	1.14
Liver	gene expression	0	0	1.08
Liver	isoform ratio	0	0	1.07
Liver	intron excision ratio	0	0	1.1
Liver	mRNA stability	0	0	1.05
NAcc	alternative polyA	0	0	1.09
NAcc	alternative TSS	0	0	1.02
NAcc	gene expression	0	0	1.06
NAcc	isoform ratio	0	0	1.08
NAcc	intron excision ratio	0	0	1.09
NAcc	mRNA stability	0	0	1.07
OFC	alternative polyA	0	0	1.14
OFC	alternative TSS	0	0	1.08
OFC	gene expression	0	0	1.02
OFC	isoform ratio	0	0	1.06
OFC	intron excision ratio	0	0	1.06
OFC	mRNA stability	0	0	1.06
PL	alternative polyA	0	0	1.1
PL	alternative TSS	0	0	0.99
PL	gene expression	0	0	1.06
PL	isoform ratio	0	0	1.1
PL	intron excision ratio	0	0	1.07
PL	mRNA stability	0	0	1.09
pVTA	alternative polyA	0	0	1.18
pVTA	alternative TSS	0	0	1.07
pVTA	gene expression	0	0	1.09
pVTA	isoform ratio	0	0	1.13
pVTA	intron excision ratio	0	0	1.08
pVTA	mRNA stability	0	0	1.09
RMTg	alternative polyA	1	0.2	1.16
RMTg	alternative TSS	0	0	1.16
RMTg	gene expression	0	0	1.09
RMTg	isoform ratio	0	0	1.12
RMTg	intron excision ratio	0	0	1.17
RMTg	mRNA stability	0	0	1.1