Hub : Traits

Short access day 1 total infusions

Tags: Behavior · Cocaine · Short access

Project: p50_paul_meyer_2020

3 loci · 3 genes with independent associations · 3 total associated genes

Significant Loci

#	Chr	Start pos	End pos	# assoc genes	# joint models	Best TWAS P	Best GWAS P	Cond GWAS P	Joint genes
1	10	46789397	48185455	1	1	3.34e-16	1.71e-01	1.00e+00	Trim16
2	10	62271668	63667097	1	1	3.68e-08	1.49e-01	4.71e-18	Eral1
3	11	39057816	40174684	1	1	7.18e-11	1.66e-02	1.00e+00	Epha6

Pleiotropic Associations

Trait	Chi2 ratio	# genes+	# genes++	% genes++	Corr	Corr P	Genes
Heart weight	6.12	2	0	0	0	1.00e+00	Trim16 Epha6
Liver weight, left	7.8	1	0	0	0	1.00e+00	Trim16
Parametrial fat weight	16.59	1	1	33.3	0	1.00e+00	Epha6
Intraocular pressure	22.02	2	1	33.3	0	1.00e+00	Trim16 Epha6
Tibia length	2.39	1	0	0	0	1.00e+00	Epha6
Number of licking bursts	19.25	1	0	0	0	1.00e+00	Trim16
Food consumed during 24 hour testing period	12.98	3	0	0	0	1.00e+00	Trim16 Eral1 Epha6
Times rat made contact with spout	16.4	3	0	0	-0.98	2.15e-02	Trim16 Eral1 Epha6
Mean time between licks in bursts	5.57	1	0	0	0	1.00e+00	Eral1
Mean num. licks in bursts	31.3	2	1	33.3	0	1.00e+00	Trim16 Eral1
Std. dev. time between licks in bursts	9.63	2	0	0	0	1.00e+00	Trim16 Eral1
Water consumed over 24 hours	18.33	2	1	33.3	0	1.00e+00	Trim16 Epha6
Indifference point 0 sec	7.93	1	0	0	0	1.00e+00	Trim16
Delay discounting total patch changes 0 sec	8.46	1	0	0	0	1.00e+00	Trim16
Delay discounting total patch changes 12 sec	11.65	1	0	0	0	1.00e+00	Epha6
Delay discounting total patch changes 18 sec	24.01	2	1	33.3	0	1.00e+00	Trim16 Epha6
Delay discounting total patch changes 6 sec	9.37	2	0	0	0	1.00e+00	Trim16 Epha6
Delay discounting water rate 0 sec	15.05	1	0	0	0	1.00e+00	Trim16
Delay discounting water rate 18 sec	10.67	1	0	0	0	1.00e+00	Epha6
Delay discounting water rate 6 sec	7.21	1	0	0	0	1.00e+00	Trim16
Locomotor activity	6.23	2	0	0	0	1.00e+00	Trim16 Epha6
Locomotor testing distance	7.95	1	0	0	0	1.00e+00	Epha6
Reaction time number correct	7.52	1	0	0	0	1.00e+00	Trim16
Reaction time trials correct on left	7.52	1	0	0	0	1.00e+00	Trim16
Reaction time trials on left	6.91	1	0	0	0	1.00e+00	Trim16
Reaction time premature initiation rate	7.78	2	0	0	0	1.00e+00	Trim16 Epha6
Reaction time premature initiations	5.85	1	0	0	0	1.00e+00	Epha6
Reaction time trials completed	6.91	1	0	0	0	1.00e+00	Trim16
Reaction time trials AUC	5.96	1	0	0	0	1.00e+00	Trim16
Social time	25.91	1	1	33.3	0	1.00e+00	Trim16
Conditioned locomotion	14.73	1	0	0	0	1.00e+00	Epha6
Cocaine response after cond. corrected	14.58	1	0	0	0	1.00e+00	Trim16
Cocaine response after cond. not corrected	16	1	0	0	0	1.00e+00	Trim16
Cocaine response before conditioning	6.74	1	0	0	0	1.00e+00	Epha6
Condit. Reinf. lever presses	6.48	2	0	0	0	1.00e+00	Trim16 Epha6
Pavlov. Cond. lever latency	5.89	1	0	0	0	1.00e+00	Epha6
Pavlov. Cond. lever contacts	7.02	1	0	0	0	1.00e+00	Epha6
Pavlov. Cond. magazine entry number	6.55	1	0	0	0	1.00e+00	Epha6
Conditioned reinforcement - actives	21.15	1	0	0	0	1.00e+00	Epha6
Conditioned reinforcement - inactives	27.02	1	1	33.3	0	1.00e+00	Epha6
Intermittent access intake escalation 2	6.45	1	0	0	0	1.00e+00	Eral1
Intermitt. access day 1 inactive lever presses	21.22	2	1	33.3	0	1.00e+00	Trim16 Eral1
Intermitt. access day 15 inactive lever presses	19.83	1	0	0	0	1.00e+00	Eral1
Intermitt. access escalation Index	27.6	1	0	0	0	1.00e+00	Trim16
Intermittent access day 1 total infusions	10.58	1	0	0	0	1.00e+00	Epha6
Intermittent access day 15 total infusions	13.65	1	0	0	0	1.00e+00	Epha6
Intermittent access terminal intake (last 3 days)	19.39	1	0	0	0	1.00e+00	Epha6
Intermittent access total infusions	17.65	1	0	0	0	1.00e+00	Epha6
Intermittent access day 1 locomotion	12.82	1	0	0	0	1.00e+00	Trim16
Intermittent access total locomotion	8.6	2	0	0	0	1.00e+00	Trim16 Eral1
Cocaine induced anxiety	20.82	2	1	33.3	0	1.00e+00	Trim16 Epha6
Post-drug Anxiety	8.24	2	0	0	0	1.00e+00	Trim16 Epha6
Baseline Anxiety	22.49	2	1	33.3	0	1.00e+00	Trim16 Epha6
Lifetime Intake	31.57	1	1	33.3	0	1.00e+00	Epha6
Incentive Sensitization - Responses	9.27	1	0	0	0	1.00e+00	Epha6
Incentive Sensitization - Breakpoint	8.83	1	0	0	0	1.00e+00	Epha6
Progressive ratio test 1 active lever presses	25.44	1	1	33.3	0	1.00e+00	Epha6
Progressive ratio test 1 breakpoint	30.13	1	1	33.3	0	1.00e+00	Epha6
Progressive ratio test 1 inactive lever presses	9.65	2	0	0	0	1.00e+00	Trim16 Epha6
Progressive ratio test 2 active lever presses	31.2	1	1	33.3	0	1.00e+00	Epha6
Progressive ratio test 2 breakpoint	24.05	1	1	33.3	0	1.00e+00	Epha6
Progressive ratio test 2 inactive lever presses	29.3	1	1	33.3	0	1.00e+00	Epha6
Total sessions with >9 infusions	15.05	2	0	0	0	1.00e+00	Trim16 Epha6
Short access day 1 total inactive lever presses	8.97	2	0	0	0	1.00e+00	Trim16 Epha6
Short access total infusions	32.76	2	1	33.3	0	1.00e+00	Eral1 Epha6
Short access day 1 locomotion	28.18	2	1	33.3	0	1.00e+00	Trim16 Eral1
Short access day 10 total locomotion	14.27	1	0	0	0	1.00e+00	Trim16
Short access total locomotion	16.94	2	0	0	0	1.00e+00	Trim16 Eral1
Compulsive drug intake	11.93	1	0	0	0	1.00e+00	Trim16
One hour access (0.3 mA shock)	33.5	1	1	33.3	0	1.00e+00	Epha6
One hour access (shock baseline)	19.56	1	0	0	0	1.00e+00	Epha6
Number of responses in last shaping day	25.55	1	1	33.3	0	1.00e+00	Trim16
Locomotion distance, session 1	17.37	2	1	33.3	0	1.00e+00	Trim16 Epha6
Locomotion distance, session 2	15.7	1	0	0	0	1.00e+00	Trim16
Stereotopy head waving bouts, day 3	8.94	1	0	0	0	1.00e+00	Epha6
Locomotion velocity, session 7	6.82	1	0	0	0	1.00e+00	Epha6
Locomotion distance, session 7	12.27	1	0	0	0	1.00e+00	Epha6
Stereotopy head waving bouts, day 7	25.38	1	1	33.3	0	1.00e+00	Trim16
Stereotopy head waving duration, day 7	6.53	1	0	0	0	1.00e+00	Trim16
Locomotion distance, session 8	5.02	1	0	0	0	1.00e+00	Epha6
Degree of sensitization stereotypy	7.41	1	0	0	0	1.00e+00	Trim16
Condit. Reinf. active minus inactive responses	9.43	1	0	0	0	1.00e+00	Epha6
Condit. Reinf. active-inactive response ratio	8.4	1	0	0	0	1.00e+00	Epha6
Condit. Reinf. active responses	7.45	1	0	0	0	1.00e+00	Epha6
Incentive salience index mean	8.35	2	0	0	0	1.00e+00	Trim16 Epha6
Condit. Reinf. lever presses	8.2	1	0	0	0	1.00e+00	Epha6
Time in familiar zone, hab. session 1	9.26	1	0	0	0	1.00e+00	Epha6
Time in novel zone, hab. session 1	6.66	1	0	0	0	1.00e+00	Epha6
Total zone transitions, hab. session 1	22.76	2	1	33.3	0	1.00e+00	Trim16 Epha6
Total locomotion distance, hab. session 1	21.63	2	1	33.3	0	1.00e+00	Trim16 Epha6
Locomotion velocity, hab. session 1	19.17	2	1	33.3	0	1.00e+00	Trim16 Epha6
Time in familiar zone, hab. session 2	22.8	2	1	33.3	0	1.00e+00	Trim16 Epha6
Time in novel zone, hab. session 2	25.18	1	1	33.3	0	1.00e+00	Epha6
Total zone transitions, hab. session 2	7.43	1	0	0	0	1.00e+00	Epha6
Total locomotion distance, hab. session 2	9.29	2	0	0	0	1.00e+00	Trim16 Epha6
Locomotion velocity, hab. session 2	8.71	2	0	0	0	1.00e+00	Trim16 Epha6
Total locomotion distance, NPP test	4.55	1	0	0	0	1.00e+00	Trim16
Pavlov. Cond. lever latency	14.56	1	0	0	0	1.00e+00	Epha6
Pavlov. Cond. magazine entry latency	31.27	2	2	66.7	0	1.00e+00	Trim16 Epha6
Pavlov. Cond. change in total contacts	7.31	1	0	0	0	1.00e+00	Epha6
Pavlov. Cond. index score	19.78	2	1	33.3	0	1.00e+00	Trim16 Epha6
Pavlov. Cond. latency score	16.89	2	1	33.3	0	1.00e+00	Trim16 Epha6
Pavlov. Cond. lever contacts	20.49	1	1	33.3	0	1.00e+00	Epha6
Pavlov. Cond. magazine entry number	17.9	2	1	33.3	0	1.00e+00	Trim16 Epha6
Pavlov. Cond. intertrial magazine entries	14.36	1	0	0	0	1.00e+00	Trim16
Pavlov. Cond. lever-magazine prob. diff.	18.69	2	1	33.3	0	1.00e+00	Trim16 Epha6
Pavlov. Cond. response bias	19.16	2	1	33.3	0	1.00e+00	Trim16 Epha6
Bone surface	4.2	1	0	0	0	1.00e+00	Epha6
Bone: connectivity density	4.61	1	0	0	0	1.00e+00	Epha6
Bone: cortical apparent density	18.12	1	0	0	0	1.00e+00	Trim16
Bone: cortical porosity	21.5	1	0	0	0	1.00e+00	Trim16
Bone: cortical porosity	27.37	1	1	33.3	0	1.00e+00	Trim16
Bone: cortical thickness	13.39	1	0	0	0	1.00e+00	Epha6
Bone: cortical tissue density	19.62	1	0	0	0	1.00e+00	Trim16
Bone: elastic work	5.85	1	0	0	0	1.00e+00	Trim16
Bone: endosteal estimation	3.29	1	0	0	0	1.00e+00	Epha6
Bone: marrow area	2.98	1	0	0	0	1.00e+00	Epha6
Bone: maximum diameter	6.08	1	0	0	0	1.00e+00	Epha6
Bone: periosteal perimeter	4.91	1	0	0	0	1.00e+00	Epha6
Bone: post-yield work	16.22	1	0	0	0	1.00e+00	Trim16
Bone: stiffness	6.97	1	0	0	0	1.00e+00	Epha6
Bone: tissue strength	7.44	1	0	0	0	1.00e+00	Trim16
Breakpoint value in progressive ratio session	7.34	1	0	0	0	1.00e+00	Eral1
Distance traveled before self-admin	58.43	1	1	33.3	0	1.00e+00	Eral1
Distance traveled after self-admin	7.49	1	0	0	0	1.00e+00	Eral1
Delta time in open arm before/after self-admin	8.04	1	0	0	0	1.00e+00	Eral1
Extinction: sum of active levers before priming	8.22	1	0	0	0	1.00e+00	Eral1
Active lever presses in extinction session 6	20.19	1	0	0	0	1.00e+00	Eral1
Delta distance traveled before/after self-admin	8.53	1	0	0	0	1.00e+00	Eral1
Delta ambulatory time before/after self-admin	37.49	1	1	33.3	0	1.00e+00	Eral1
Time in open arm after self-admin	10.52	1	0	0	0	1.00e+00	Eral1
Time to tail flick, vehicle, before self-admin	10.06	1	0	0	0	1.00e+00	Eral1
Time to tail flick, test, before self-admin	6.51	1	0	0	0	1.00e+00	Epha6
Delta time to tail flick, vehicle, before/after SA	8	1	0	0	0	1.00e+00	Epha6
Ambulatory time before self-admin	49.07	1	1	33.3	0	1.00e+00	Eral1
Ambulatory time after self-admin	6.62	1	0	0	0	1.00e+00	Eral1
Area under the delay curve	26.04	2	1	33.3	0	1.00e+00	Eral1 Epha6
Delay disc. indifference point, 0s delay	11.52	1	0	0	0	1.00e+00	Epha6
Delay disc. indifference point, 16s delay	35.23	2	1	33.3	0	1.00e+00	Trim16 Eral1
Delay disc. indifference point, 24s delay	9.47	1	0	0	0	1.00e+00	Eral1
Delay disc. indifference point, 4s delay	8.65	2	0	0	0	1.00e+00	Eral1 Epha6
Delay disc. indifference point, 8s delay	39.89	2	1	33.3	0	1.00e+00	Eral1 Epha6
Delay discount exponential model param	21.45	2	1	33.3	0	1.00e+00	Eral1 Epha6
Delay discount hyperbolic model param	18.19	2	1	33.3	0	1.00e+00	Eral1 Epha6
Bouts of movement, locomotor time 1	7.86	1	0	0	0	1.00e+00	Epha6
Rest time, locomotor task time 1	15.21	1	0	0	0	1.00e+00	Eral1
Vertical activity count, locomotor time 1	7.25	1	0	0	0	1.00e+00	Epha6
Time >=10cm from walls, locomotor time 2	39.82	1	1	33.3	0	1.00e+00	Eral1
Rest time, locomotor task time 2	5.62	2	0	0	0	1.00e+00	Eral1 Epha6
Distance moved, locomotor task time 2	9.99	2	0	0	0	1.00e+00	Trim16 Eral1
Vertical activity count, locomotor time 2	8.68	1	0	0	0	1.00e+00	Eral1
Seeking ratio, delayed vs. immediate footshock	11.05	1	0	0	0	1.00e+00	Epha6
Locomotion in novel chamber post-restriction	14.73	2	0	0	0	1.00e+00	Eral1 Epha6
Progressive ratio	27.88	1	1	33.3	0	1.00e+00	Eral1
Food seeking constrained by brief footshock	13.98	1	0	0	0	1.00e+00	Eral1
Seeking ratio, punishment vs. effort	10.23	1	0	0	0	1.00e+00	Eral1
Run reversals in cocaine runway, females	11.6	1	0	0	0	1.00e+00	Trim16
Run reversals in cocaine runway, males	48.09	1	1	33.3	0	1.00e+00	Eral1
Latency to leave start box in cocaine runway	10.1	3	0	0	-0.6	4.01e-01	Trim16 Eral1 Epha6
Latency to leave start box in cocaine runway, F	7.35	1	0	0	0	1.00e+00	Trim16
Latency to leave start box in cocaine runway, M	38.49	1	1	33.3	0	1.00e+00	Eral1
Cu content in liver	6.23	1	0	0	0	1.00e+00	Trim16
K content in liver	8.32	1	0	0	0	1.00e+00	Trim16
Mg content in liver	28.9	1	1	33.3	0	1.00e+00	Trim16
Na content in liver	10.19	1	0	0	0	1.00e+00	Epha6
Rb content in liver	24.76	1	1	33.3	0	1.00e+00	Trim16
Se content in liver	14	2	0	0	0	1.00e+00	Trim16 Epha6

Associations by panel

Tissue	RNA modality	# hits	% hits/tests	Avg chisq
Adipose	alternative polyA	0	0	1.15
Adipose	alternative TSS	0	0	1.19
Adipose	gene expression	1	0	1.07
Adipose	isoform ratio	0	0	1.06
Adipose	intron excision ratio	0	0	1.14
Adipose	mRNA stability	0	0	1.05
BLA	alternative polyA	0	0	0.97
BLA	alternative TSS	0	0	1.05
BLA	gene expression	0	0	1.08
BLA	isoform ratio	0	0	1.05
BLA	intron excision ratio	0	0	1.05
BLA	mRNA stability	0	0	1.09
Brain	alternative polyA	0	0	0.98
Brain	alternative TSS	0	0	1.01
Brain	gene expression	0	0	1.07
Brain	isoform ratio	0	0	1.09
Brain	intron excision ratio	0	0	1.03
Brain	mRNA stability	0	0	1.06
Eye	alternative polyA	0	0	1.06
Eye	alternative TSS	0	0	0.94
Eye	gene expression	0	0	1.15
Eye	isoform ratio	0	0	1.02
Eye	intron excision ratio	0	0	0.95
Eye	mRNA stability	0	0	1.09
IL	alternative polyA	0	0	0.95
IL	alternative TSS	0	0	1.03
IL	gene expression	0	0	1.03
IL	isoform ratio	0	0	0.98
IL	intron excision ratio	0	0	1.05
IL	mRNA stability	0	0	1.12
LHb	alternative polyA	0	0	0.96
LHb	alternative TSS	0	0	1.19
LHb	gene expression	0	0	1.08
LHb	isoform ratio	0	0	1.04
LHb	intron excision ratio	0	0	1.09
LHb	mRNA stability	0	0	1.11
Liver	alternative polyA	0	0	1.06
Liver	alternative TSS	0	0	1.06
Liver	gene expression	0	0	1.08
Liver	isoform ratio	0	0	1.13
Liver	intron excision ratio	0	0	1.09
Liver	mRNA stability	0	0	1.04
NAcc	alternative polyA	0	0	0.92
NAcc	alternative TSS	0	0	1.08
NAcc	gene expression	0	0	1.06
NAcc	isoform ratio	0	0	1.03
NAcc	intron excision ratio	0	0	1.1
NAcc	mRNA stability	0	0	1.1
OFC	alternative polyA	0	0	1.11
OFC	alternative TSS	0	0	0.91
OFC	gene expression	0	0	1.06
OFC	isoform ratio	0	0	1.07
OFC	intron excision ratio	0	0	1.04
OFC	mRNA stability	0	0	1.09
PL	alternative polyA	0	0	0.98
PL	alternative TSS	2	0.2	1.11
PL	gene expression	1	0	1.08
PL	isoform ratio	0	0	1.05
PL	intron excision ratio	0	0	1.07
PL	mRNA stability	0	0	1.1