Hub : Traits

Time to tail flick, vehicle, after self-admin

Time in sec to remove tail from noxious stimuli under vehicle conditions in the second tail flick after self admin

Tags: Behavior · Heroin

Project: u01_peter_kalivas

1 significantly associated model · 1 unique gene

Significant Loci

# chr p0 p1 # assoc genes # joint models best TWAS P best SNP P cond SNP P % var exp joint genes
1 8 108584253 109845634 1 1 2.2e-07 0.21 0.053 -135 Ccdc71

p0: physical position of the start of the locus. p1: physical position of the end of the locus. # joint models: number of models selected by step-wise conditional analysis.

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
BMI with tail 1.9 1 0 0 0 1 Ccdc71
Body weight 1.8 1 0 0 0 1 Ccdc71
Heart weight 11.6 1 0 0 0 1 Ccdc71
Liver weight, left 5.1 1 0 0 0 1 Ccdc71
Indifference point AUC 6.2 1 0 0 0 1 Ccdc71
Indifference point function ln k 5.3 1 0 0 0 1 Ccdc71
Indifference point function log k 5.3 1 0 0 0 1 Ccdc71
Delay discounting total patch changes 18 sec 4.5 1 0 0 0 1 Ccdc71
Delay discounting total patch changes 6 sec 4.1 1 0 0 0 1 Ccdc71
Locomotor activity 9.0 1 0 0 0 1 Ccdc71
Locomotor testing distance 8.0 1 0 0 0 1 Ccdc71
Light reinforcement 2 2.9 1 0 0 0 1 Ccdc71
Reaction time num false alarms 5.8 1 0 0 0 1 Ccdc71
Reaction time num false alarms AUC 5.6 1 0 0 0 1 Ccdc71
Reaction time false alarm rate 7.4 1 0 0 0 1 Ccdc71
Short access day 10 total inactive lever presses 5.6 1 0 0 0 1 Ccdc71
Short access day 1 locomotion 9.4 1 0 0 0 1 Ccdc71
Short access total locomotion 4.4 1 0 0 0 1 Ccdc71
One hour access (0.3 mA shock) 4.6 1 0 0 0 1 Ccdc71
Locomotion velocity, session 2 4.6 1 0 0 0 1 Ccdc71
Locomotion distance, session 2 3.1 1 0 0 0 1 Ccdc71
Condit. Reinf. active minus inactive responses 3.9 1 0 0 0 1 Ccdc71
Total zone transitions, hab. session 2 4.7 1 0 0 0 1 Ccdc71
Total zone transitions, NPP test 5.3 1 0 0 0 1 Ccdc71
Pavlov. Cond. change in total contacts 6.2 1 0 0 0 1 Ccdc71
Delta time in closed arm before/after self-admin 7.6 1 0 0 0 1 Ccdc71
Active lever presses in extinction session 6 9.2 1 0 0 0 1 Ccdc71
Time in open arm after self-admin 4.2 1 0 0 0 1 Ccdc71
Time to tail flick, test, before self-admin 5.2 1 0 0 0 1 Ccdc71
Delta time to tail flick, vehicle, before/after SA 14.7 1 0 0 0 1 Ccdc71
Total heroin consumption 11.7 1 0 0 0 1 Ccdc71
Delay disc. indifference point, 0s delay 11.7 1 0 0 0 1 Ccdc71
Delay disc. indifference point, 4s delay 8.2 1 0 0 0 1 Ccdc71
Fecal boli incidents, locomotor time 1 3.7 1 0 0 0 1 Ccdc71
Rest time, locomotor task time 1 4.0 1 0 0 0 1 Ccdc71
Distance moved, locomotor task time 1 8.4 1 0 0 0 1 Ccdc71
Vertical activity count, locomotor time 1 13.2 1 0 0 0 1 Ccdc71
Rest time, locomotor task time 2 5.4 1 0 0 0 1 Ccdc71
Distance moved, locomotor task time 2 12.1 1 0 0 0 1 Ccdc71
Vertical activity count, locomotor time 2 13.6 1 0 0 0 1 Ccdc71
Weight adjusted by age 9.6 1 0 0 0 1 Ccdc71
Run reversals in cocaine runway, females 10.4 1 0 0 0 1 Ccdc71
Run reversals in cocaine runway, males 7.9 1 0 0 0 1 Ccdc71
Latency to leave start box in cocaine runway, M 11.2 1 0 0 0 1 Ccdc71
Fe content in liver 3.8 1 0 0 0 1 Ccdc71
Rb content in liver 5.2 1 0 0 0 1 Ccdc71

chisq ratio: Average Chi2 statistic for the selected genes in the secondary trait, divided by the average statistic for all genes in the secondary trait. # genes+: Shared significant genes at Bonferroni correction. # genes++: Shared significant genes at transcriptome-wide significance. % genes++: Number of [++] genes as a percentage of primary trait’s total joint genes. corr: Correlation of effect sizes across the [+] genes.

Associations by panel

tissue modality # hits % hits/tests avg chisq
Adipose alternative polyA 0 0.00 1.06
Adipose alternative TSS 0 0.00 1.05
Adipose gene expression 0 0.00 1.08
Adipose isoform ratio 0 0.00 1.06
Adipose intron excision ratio 0 0.00 1.02
Adipose mRNA stability 0 0.00 1.09
BLA alternative polyA 0 0.00 1.11
BLA alternative TSS 0 0.00 1.05
BLA gene expression 0 0.00 1.12
BLA isoform ratio 0 0.00 1.09
BLA intron excision ratio 0 0.00 1.09
BLA mRNA stability 0 0.00 1.06
Brain alternative polyA 0 0.00 1.11
Brain alternative TSS 0 0.00 1.03
Brain gene expression 0 0.00 1.08
Brain isoform ratio 0 0.00 1.07
Brain intron excision ratio 0 0.00 1.05
Brain mRNA stability 0 0.00 1.06
Eye alternative polyA 0 0.00 0.94
Eye alternative TSS 0 0.00 1.29
Eye gene expression 0 0.00 1.08
Eye isoform ratio 0 0.00 1.15
Eye intron excision ratio 0 0.00 0.97
Eye mRNA stability 0 0.00 0.95
IL alternative polyA 0 0.00 0.98
IL alternative TSS 0 0.00 0.98
IL gene expression 0 0.00 1.03
IL isoform ratio 0 0.00 0.99
IL intron excision ratio 0 0.00 1.04
IL mRNA stability 0 0.00 1.09
LHb alternative polyA 0 0.00 1.07
LHb alternative TSS 0 0.00 1.02
LHb gene expression 0 0.00 1.10
LHb isoform ratio 1 0.13 1.13
LHb intron excision ratio 0 0.00 1.02
LHb mRNA stability 0 0.00 1.05
Liver alternative polyA 0 0.00 1.08
Liver alternative TSS 0 0.00 1.12
Liver gene expression 0 0.00 1.08
Liver isoform ratio 0 0.00 1.09
Liver intron excision ratio 0 0.00 1.00
Liver mRNA stability 0 0.00 1.10
NAcc alternative polyA 0 0.00 1.09
NAcc alternative TSS 0 0.00 1.00
NAcc gene expression 0 0.00 1.08
NAcc isoform ratio 0 0.00 1.11
NAcc intron excision ratio 0 0.00 1.05
NAcc mRNA stability 0 0.00 1.11
OFC alternative polyA 0 0.00 1.10
OFC alternative TSS 0 0.00 1.15
OFC gene expression 0 0.00 1.06
OFC isoform ratio 0 0.00 1.04
OFC intron excision ratio 0 0.00 1.03
OFC mRNA stability 0 0.00 1.04
PL alternative polyA 0 0.00 1.05
PL alternative TSS 0 0.00 1.07
PL gene expression 0 0.00 1.09
PL isoform ratio 0 0.00 1.05
PL intron excision ratio 0 0.00 1.05
PL mRNA stability 0 0.00 1.10

avg chisq: Average Chi2 (squared Z-score) across all models in this panel for this trait.