Rhog

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Liver	gene expression	Rhog	0.18	0.09	1.8e-15	0.12	0.12	0.11	0.11	4.4e-13	4.3e-13	2.4e-12	1.3e-12
2	Adipose	gene expression	Rhog	0.03	0.02	9.0e-03	0.01	0	0	0	1.2e-02	2.2e-01	2.9e-01	7.2e-02
3	Liver	mRNA stability	Rhog	0.05	0.05	7.8e-03	0.02	0.01	0	0.01	4.7e-03	2.8e-02	3.6e-01	1.1e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3
Bone: apparent density	0.4	0.7	1.4	-0.5	0.7	1.2
Area under the delay curve	0.8	0.8	0.9	-0.9	0.9	0.9
BMI with tail	0.1	0.4	0.7	-0.7	0.8	0.3
BMI without tail	0.9	1.8	2.5	1.2	-1.2	-1.6
Body weight	0.9	3.6	8.8	0.9	-1.1	-3.0
Weight adjusted by age	1.8	2.1	2.5	1.4	-1.6	-1.4
Bone surface	0.3	0.6	0.9	1.0	-0.9	-0.1
Bone volume	0.2	0.3	0.4	0.7	-0.6	-0.2
Breakpoint value in progressive ratio session	0.6	0.7	1.1	-0.5	0.8	1.0
Number of licking bursts	3.3	3.9	6.1	-2.5	2.3	0.6
Context. condit. distance diff. score	2.7	3.2	5.2	2.3	-2.1	-0.3
Locomotion velocity, session 1	1.1	1.1	2.0	-0.7	1.0	1.4
Locomotion distance, session 1	0.3	0.4	0.5	0.7	-0.6	0.5
Locomotion velocity, session 2	0.2	0.2	0.7	0.1	0.2	0.8
Locomotion distance, session 2	0.1	0.1	0.2	0.5	-0.3	0.3
Locomotion velocity, session 3	0.5	0.5	0.9	0.9	-0.8	0.4
Locomotion distance, session 3	0.8	0.9	1.2	1.1	-0.9	0.8
Stereotopy head waving bouts, day 3	0.2	0.3	0.7	-0.1	-0.1	-0.9
Stereotopy head waving duration, day 3	0.2	0.2	0.3	0.6	-0.5	-0.1
Locomotion velocity, session 7	0.3	0.4	0.8	-0.3	0.5	0.9
Locomotion distance, session 7	0.2	0.2	0.3	-0.5	0.5	-0.2
Stereotopy head waving bouts, day 7	2.6	2.9	4.6	2.2	-2.0	0.2
Stereotopy head waving duration, day 7	2.6	3.1	5.0	2.2	-2.1	0.2
Locomotion velocity, session 8	1.0	1.2	2.1	1.4	-1.2	0.0
Locomotion distance, session 8	2.0	2.9	4.6	2.1	-2.0	-0.5
Degree of sensitization distance	1.1	1.2	3.1	-0.5	0.4	-1.7
Degree of sensitization stereotypy	4.9	5.3	8.5	2.9	-2.7	0.1
Conditioned locomotion	0.4	0.4	0.6	-0.7	0.6	-0.6
Cocaine response after cond. corrected	1.0	1.1	1.9	-1.4	1.2	0.1
Cocaine response after cond. not corrected	0.6	0.6	0.8	-0.9	0.9	0.5
Cocaine response before conditioning	1.0	1.3	1.8	1.4	-1.1	0.9
Saline control response	2.6	3.4	3.6	1.9	-1.9	-1.8
Bone: connectivity density	1.0	1.6	4.2	-0.4	0.7	2.0
Bone: cortical apparent density	1.0	1.3	1.9	-1.4	1.2	-0.8
Bone: cortical area	0.4	0.6	1.1	0.6	-0.6	-1.0
Bone: cortical porosity	0.1	0.1	0.2	0.4	-0.3	0.4
Bone: cortical porosity	0.1	0.2	0.2	0.4	-0.4	0.4
Bone: cortical thickness	0.2	0.3	0.5	-0.6	0.7	0.4
Bone: cortical thickness	0.0	0.0	0.0	0.1	-0.1	-0.1
Bone: cortical tissue density	1.0	1.3	1.9	-1.4	1.2	-0.7
Condit. Reinf. active minus inactive responses	1.2	1.4	1.9	0.9	-1.2	-1.4
Condit. Reinf. active-inactive response ratio	1.7	1.9	2.5	1.1	-1.4	-1.6
Condit. Reinf. active responses	0.3	0.3	0.7	0.2	-0.4	-0.9
Condit. Reinf. inactive responses	0.3	0.4	0.6	-0.8	0.7	0.2
Incentive salience index mean	0.5	0.5	0.9	0.5	-0.7	-0.9
Condit. Reinf. lever presses	0.0	0.0	0.1	-0.1	-0.0	0.3
Condit. Reinf. active minus inactive responses	7.5	9.3	12.0	3.5	-3.4	-2.2
Condit. Reinf. active-inactive response ratio	1.3	1.4	2.1	1.5	-1.3	-0.4
Condit. Reinf. active responses	9.8	13.6	16.0	4.0	-3.9	-3.0
Condit. Reinf. inactive responses	6.0	7.3	7.6	2.7	-2.8	-2.7
Condit. Reinf. lever presses	14.0	19.0	25.9	5.1	-4.8	-2.7
Condit. Reinf. lever reinforcers received	10.1	14.2	17.6	4.2	-4.1	-2.8
Conditioned reinforcement - actives	0.2	0.2	0.3	0.4	-0.2	0.5
Conditioned reinforcement - inactives	0.3	0.4	0.5	-0.7	0.4	-0.7
Conditioned locomotion	0.6	0.8	1.3	1.2	-0.8	0.6
Patch foraging indifference point 0 sec	2.0	3.3	4.7	2.2	-2.1	-0.9
Patch foraging indifference point AUC	0.7	0.8	1.1	0.7	-1.0	-1.0
Delay disc. indifference point, 0s delay	0.3	0.4	0.6	0.7	-0.7	-0.2
Delay disc. indifference point, 16s delay	0.5	0.5	0.7	-0.8	0.7	0.6
Delay disc. indifference point, 2s delay	0.3	0.3	0.3	0.5	-0.6	-0.5
Delay disc. indifference point, 24s delay	1.4	1.4	2.2	-1.5	1.3	0.5
Delay disc. indifference point, 4s delay	0.5	0.5	0.5	0.7	-0.7	-0.7
Delay disc. indifference point, 8s delay	0.8	0.8	0.9	-0.8	1.0	0.9
Indifference point function ln k	0.1	0.2	0.4	0.4	-0.2	0.6
Indifference point function log k	0.1	0.2	0.4	0.4	-0.2	0.6
Patch foraging total patch changes 0 sec	1.7	2.7	3.8	2.0	-1.8	-0.9
Patch foraging total patch changes 12 sec	1.5	1.9	2.2	1.3	-1.4	-1.5
Patch foraging total patch changes 18 sec	0.9	1.2	1.7	1.2	-1.3	-0.6
Patch foraging total patch changes 24 sec	2.0	2.5	2.7	1.4	-1.6	-1.6
Patch foraging total patch changes 6 sec	1.2	1.8	2.4	1.4	-1.6	-1.0
Patch foraging time to switch 0 sec	3.9	6.1	7.9	-2.7	2.8	1.7
Patch foraging water rate 0 sec	3.0	4.8	6.1	2.4	-2.5	-1.6
Patch foraging water rate 12 sec	1.4	2.1	3.1	1.8	-1.7	-0.6
Patch foraging water rate 18 sec	2.7	3.6	5.0	2.2	-2.0	-1.4
Patch foraging water rate 24 sec	0.1	0.2	0.4	0.6	-0.4	-0.1
Patch foraging water rate 6 sec	0.5	0.7	1.2	1.1	-0.9	0.1
Seeking ratio, delayed vs. immediate footshock	2.5	2.9	3.5	-1.6	1.6	1.9
Distance traveled before self-admin	0.6	0.6	0.7	-0.8	0.7	0.8
Distance traveled after self-admin	0.2	0.2	0.4	0.4	-0.3	0.6
Extensor digitorum longus weight	0.1	0.3	0.5	-0.7	0.7	-0.2
Bone: elastic displacement	1.9	2.2	2.5	-1.5	1.6	1.3
Bone: elastic work	3.1	3.9	4.2	-1.9	2.0	2.0
Bone: endosteal estimation	1.1	2.5	3.1	1.4	-1.5	-1.8
Bone: endosteal perimeter	1.6	3.3	3.5	1.8	-1.9	-1.7
Epididymis fat weight	0.4	0.9	1.2	-0.8	0.8	-1.1
Delta time in closed arm before/after self-admin	0.8	0.8	1.1	-0.9	0.7	-1.1
Delta time in open arm before/after self-admin	2.7	2.6	4.0	1.7	-2.0	-0.9
Diff in mean of infusions in LGA sessions	1.0	1.1	1.9	-1.4	1.0	-0.5
Delay discount exponential model param	1.1	1.2	1.2	1.1	-1.1	-1.1
Extinction: sum of active levers before priming	0.3	0.2	0.5	-0.5	0.7	0.1
Active lever presses in extinction session 6	1.4	1.3	1.8	1.3	-1.2	0.8
Bone: final force	0.2	0.4	0.6	-0.6	0.5	-0.8
Bone: final moment	0.2	0.3	0.8	-0.3	0.2	-0.9
Food consumed during 24 hour testing period	2.0	2.4	4.0	2.0	-1.8	0.0
Glucose	0.2	0.4	1.1	0.0	0.1	1.0
Heart weight	1.4	2.0	2.7	1.5	-1.6	-1.1
Delay discount hyperbolic model param	0.6	0.7	0.7	0.8	-0.8	-0.8
Intermittent access intake day 1-15 change	0.5	0.5	0.9	0.9	-0.9	0.1
Intermittent access intake escalation	0.4	0.4	0.5	0.7	-0.7	0.3
Intermittent access intake escalation 2	0.0	0.0	0.0	-0.2	0.1	-0.2
Intermitt. access day 1 inactive lever presses	0.8	0.9	1.6	-1.3	0.9	-0.5
Intermitt. access day 15 inactive lever presses	0.7	0.8	1.3	0.8	-1.1	-0.7
Intermitt. access escalation Index	0.2	0.2	0.5	0.0	-0.2	-0.7
Intermittent access day 1 total infusions	0.5	0.6	0.9	0.9	-0.8	-0.3
Intermittent access day 15 total infusions	0.4	0.5	0.7	0.9	-0.9	-0.1
Intermittent access terminal intake (last 3 days)	0.4	0.4	0.6	0.8	-0.7	-0.3
Intermittent access total infusions	0.2	0.2	0.3	0.6	-0.5	-0.1
Intermittent access day 1 locomotion	0.1	0.1	0.3	-0.1	0.1	0.6
Intermittent access day 15 total locomotion	0.5	0.6	0.7	0.8	-0.7	0.8
Intermittent access total locomotion	0.3	0.3	0.5	0.7	-0.6	0.2
Intermittent access standard deviation	0.1	0.1	0.1	-0.3	0.3	0.1
Left kidney weight	1.6	4.4	5.7	1.8	-2.0	-2.4
Right kidney weight	1.0	2.9	4.5	1.3	-1.5	-2.1
Cocaine induced anxiety	2.3	2.6	4.3	-2.1	1.9	0.1
Post-drug Anxiety	0.5	0.6	1.5	-0.5	0.1	-1.2
Baseline Anxiety	2.7	2.8	4.0	1.8	-2.0	-1.2
Tail length	6.4	19.5	26.6	3.8	-4.2	-5.2
Length with tail	3.7	13.4	24.3	2.6	-3.0	-4.9
Length without tail	0.1	0.3	0.4	-0.6	0.4	-0.5
Times rat made contact with spout	0.2	0.2	0.3	-0.6	0.5	-0.2
Lifetime Intake	0.5	0.5	0.9	0.9	-0.9	-0.2
Liver weight, left	1.3	2.0	2.9	-1.7	1.6	-0.8
Liver weight, right	1.2	2.1	3.8	-1.3	0.9	-1.9
Locomotor activity	0.4	0.6	0.8	0.9	-0.7	-0.7
Locomotor testing distance	1.4	2.4	3.5	1.9	-1.6	-1.1
Locomotor testing rearing	0.7	1.1	1.2	1.1	-0.9	-1.1
Locomotion in novel chamber	0.5	0.6	1.0	-0.5	0.7	1.0
Locomotion in novel chamber post-restriction	0.6	0.7	1.2	0.8	-0.5	1.1
Fecal boli incidents, locomotor time 1	1.9	2.1	2.6	-1.6	1.6	1.1
Change in fecal boli incidents, locomotor task	0.0	0.0	0.0	0.2	0.0	0.1
Time >=10cm from walls, locomotor time 1	0.5	0.5	0.7	0.9	-0.8	-0.3
Bouts of movement, locomotor time 1	0.2	0.2	0.6	0.3	-0.8	-0.1
Total resting periods, locomotor time 1	0.1	0.1	0.2	-0.2	-0.2	0.5
Rest time, locomotor task time 1	0.0	0.0	0.0	0.0	-0.0	0.0
Distance moved, locomotor task time 1	0.0	0.0	0.1	0.0	0.0	-0.3
Vertical activity count, locomotor time 1	0.1	0.1	0.3	-0.2	0.1	-0.5
Time >=10cm from walls, locomotor time 2	2.9	3.1	3.6	1.8	-1.9	-1.6
Bouts of movement, locomotor time 2	0.2	0.2	0.5	-0.1	-0.2	-0.7
Total resting periods, locomotor time 2	0.1	0.2	0.3	-0.5	0.3	-0.3
Rest time, locomotor task time 2	2.7	3.1	4.0	-2.0	2.0	1.1
Distance moved, locomotor task time 2	2.6	3.0	3.8	2.0	-1.9	-1.2
Vertical activity count, locomotor time 2	0.3	0.4	0.5	0.5	-0.5	-0.7
Light reinforcement 1	2.2	4.0	5.3	-2.1	2.3	1.5
Light reinforcement 2	1.1	1.5	3.8	-0.4	0.8	2.0
Bone: marrow area	0.9	2.0	2.8	1.2	-1.3	-1.7
Bone: maximum diameter	1.9	3.6	4.0	2.0	-2.0	-1.7
Bone: maximum force	0.1	0.1	0.3	-0.2	0.2	-0.5
Bone: maximum moment	0.1	0.1	0.3	0.0	-0.0	-0.5
Mean time between licks in bursts	7.4	10.4	12.8	2.9	-3.1	-3.6
Mean num. licks in bursts	2.6	3.1	5.0	2.2	-2.0	-0.6
Cd content in liver	0.6	0.7	1.0	-1.0	1.0	0.3
Co content in liver	2.4	2.8	3.1	1.6	-1.8	-1.7
Cu content in liver	1.2	1.4	1.6	1.1	-1.2	-1.3
Fe content in liver	0.0	0.0	0.0	-0.2	-0.0	-0.1
K content in liver	0.4	0.4	0.7	-0.8	0.7	-0.3
Mg content in liver	0.0	0.0	0.0	0.1	-0.1	-0.1
Mn content in liver	2.9	3.3	3.6	-1.7	1.9	1.8
Na content in liver	0.2	0.3	0.3	0.5	-0.4	0.6
Rb content in liver	0.4	0.5	0.8	0.8	-0.9	-0.1
Se content in liver	4.8	5.9	7.0	-2.6	2.6	2.0
Sr content in liver	0.2	0.2	0.5	0.4	-0.1	0.7
Zn content in liver	2.1	2.3	3.6	1.9	-1.7	-0.5
Bone: minimum diameter	1.0	1.9	4.2	0.8	-0.9	-2.1
Time in familiar zone, hab. session 1	0.2	0.2	0.3	0.5	-0.3	-0.5
Time in novel zone, hab. session 1	0.1	0.1	0.3	-0.5	0.3	-0.1
Total zone transitions, hab. session 1	0.3	0.4	0.8	0.4	-0.3	0.9
Total locomotion distance, hab. session 1	0.8	1.1	3.3	-0.2	0.2	-1.8
Locomotion velocity, hab. session 1	0.6	0.8	2.4	-0.3	0.3	-1.5
Time in familiar zone, hab. session 2	3.6	3.7	4.0	1.9	-1.9	-2.0
Time in novel zone, hab. session 2	2.0	2.0	2.9	-1.2	1.3	1.7
Total zone transitions, hab. session 2	2.3	3.0	4.4	2.1	-2.0	-0.5
Total locomotion distance, hab. session 2	2.3	3.0	7.0	0.9	-1.0	-2.7
Locomotion velocity, hab. session 2	2.2	2.9	7.3	0.8	-0.9	-2.7
Novel to familiar place preference ratio	0.8	0.9	2.0	0.3	-0.7	-1.4
Novelty place preference	0.9	0.9	2.0	0.3	-0.7	-1.4
Time in novel zone, NPP test	1.2	1.2	2.5	0.6	-0.9	-1.6
Total zone transitions, NPP test	0.3	0.4	1.1	0.2	-0.0	1.0
Total locomotion distance, NPP test	0.4	0.6	1.3	-0.4	0.5	-1.1
Locomotion velocity, NPP test	0.4	0.6	0.7	-0.8	0.8	-0.8
Intraocular pressure	0.7	0.9	2.7	0.1	-0.0	1.7
Delta distance traveled before/after self-admin	2.0	2.2	2.7	1.7	-1.5	-1.2
Delta ambulatory time before/after self-admin	1.4	1.5	2.3	1.5	-1.4	-0.6
Parametrial fat weight	0.6	1.2	1.2	-1.1	1.1	1.1
Pavlov. Cond. lever latency	0.5	0.7	1.0	-0.9	1.0	0.3
Pavlov. Cond. magazine entry latency	2.8	3.6	4.8	2.2	-2.2	-1.2
Pavlov. Cond. change in total contacts	1.0	1.0	1.6	1.2	-1.2	-0.4
Pavlov. Cond. index score	1.8	2.3	3.3	1.8	-1.8	-0.6
Pavlov. Cond. latency score	1.6	2.0	2.9	1.7	-1.7	-0.5
Pavlov. Cond. lever contacts	0.5	0.6	1.0	0.9	-1.0	-0.2
Pavlov. Cond. magazine entry number	2.3	2.9	4.2	-2.0	2.0	0.6
Pavlov. Cond. intertrial magazine entries	0.9	1.1	1.4	-1.2	1.2	0.8
Pavlov. Cond. lever-magazine prob. diff.	1.4	1.8	2.6	1.6	-1.6	-0.4
Pavlov. Cond. response bias	0.9	1.0	1.5	1.2	-1.2	-0.5
Pavlov. Cond. lever latency	15.7	21.2	29.7	-5.5	5.1	2.8
Pavlov. Cond. magazine entry latency	2.9	3.4	5.8	2.4	-2.0	-0.6
Pavlov. Cond. change in total contacts	13.2	18.2	27.0	5.2	-4.8	-2.2
Pavlov. Cond. index score	11.4	14.7	21.5	4.6	-4.2	-2.2
Pavlov. Cond. latency score	9.9	12.4	18.6	4.3	-3.9	-1.8
Pavlov. Cond. lever contacts	16.4	22.3	31.2	5.6	-5.3	-2.8
Pavlov. Cond. magazine entry number	5.8	7.1	11.4	-3.4	3.0	0.9
Pavlov. Cond. intertrial magazine entries	0.4	0.5	1.1	0.3	-0.6	-1.0
Pavlov. Cond. lever-magazine prob. diff.	11.4	14.5	20.9	4.6	-4.2	-2.3
Pavlov. Cond. response bias	16.3	22.2	31.9	5.6	-5.3	-2.6
Time in closed arm before self-admin	1.7	1.9	3.1	1.8	-1.6	-0.1
Time in closed arm after self-admin	0.3	0.3	0.5	-0.7	0.7	0.3
Time in open arm before self-admin	5.0	5.5	7.8	-2.8	2.7	1.1
Time in open arm after self-admin	0.1	0.1	0.2	-0.0	-0.2	-0.4
Bone: periosteal estimation	0.7	1.5	2.1	1.1	-1.1	-1.4
Bone: periosteal perimeter	1.2	2.0	2.2	1.4	-1.4	-1.5
Bone: post-yield work	0.1	0.1	0.2	0.4	-0.3	-0.2
Progressive ratio test 1 active lever presses	0.0	0.0	0.1	0.1	-0.1	0.3
Progressive ratio test 1 breakpoint	0.0	0.0	0.0	0.1	-0.1	0.2
Progressive ratio test 1 inactive lever presses	0.0	0.0	0.0	0.0	-0.2	0.0
Progressive ratio test 2 active lever presses	0.0	0.0	0.1	0.3	-0.2	0.1
Progressive ratio test 2 breakpoint	0.1	0.1	0.1	0.4	-0.3	-0.0
Progressive ratio test 2 inactive lever presses	0.0	0.0	0.1	0.2	-0.3	0.0
Incentive Sensitization - Responses	0.3	0.3	0.5	0.7	-0.6	-0.4
Incentive Sensitization - Breakpoint	0.2	0.2	0.3	0.6	-0.5	-0.2
Sum of active levers in priming session hrs 5-6	0.0	0.0	0.1	0.3	-0.2	0.1
Progressive ratio	0.0	0.0	0.0	0.2	-0.2	0.2
Food seeking constrained by brief footshock	2.4	2.9	3.6	1.6	-1.6	-1.9
Seeking ratio, punishment vs. effort	0.7	0.9	1.4	0.9	-0.7	-1.2
Retroperitoneal fat weight	1.1	3.5	4.0	-2.0	1.7	-1.9
Reaction time number correct	0.1	0.1	0.3	0.0	-0.0	0.6
Reaction time mean minus median	0.5	0.7	1.2	0.7	-0.7	-1.1
Reaction time mean minus median AUC	0.3	0.4	0.5	0.6	-0.5	-0.7
Reaction time num false alarms	1.8	2.5	3.9	-2.0	1.9	0.0
Reaction time num false alarms AUC	1.8	2.5	3.8	-2.0	1.9	0.3
Reaction time trials correct on left	0.1	0.1	0.3	0.0	-0.0	0.6
Reaction time trials on left	0.1	0.1	0.4	-0.0	0.0	0.6
Reaction time mean	1.4	1.9	3.0	-1.7	1.6	-0.4
Reaction time mean AUC	1.6	2.2	3.5	-1.9	1.8	-0.1
Median of all reaction times	2.3	3.1	4.9	-2.2	2.1	0.0
Reaction time omissions	0.8	1.0	1.5	-1.2	1.2	0.5
Reaction time false alarm rate	1.8	2.4	3.7	-1.9	1.9	0.1
Reaction time premature initiation rate	2.6	3.5	5.7	1.5	-1.6	-2.4
Reaction time premature initiations	1.4	1.9	2.9	1.2	-1.2	-1.7
Std. dev. reaction times	0.4	0.5	1.4	-0.3	0.2	-1.2
Reaction time trials completed	0.1	0.1	0.4	-0.0	0.0	0.6
Reaction time trials AUC	0.0	0.0	0.1	0.0	-0.1	0.3
Run reversals in cocaine runway, females	1.2	1.2	2.8	0.6	-0.6	-1.7
Run reversals in cocaine runway, males	0.5	0.5	0.6	-0.8	0.6	0.8
Latency to leave start box in cocaine runway	1.4	1.5	2.4	-1.4	1.5	0.5
Latency to leave start box in cocaine runway, F	0.9	0.9	1.4	-1.1	1.2	-0.5
Latency to leave start box in cocaine runway, M	1.9	1.8	3.1	-1.0	1.2	1.8
Std. dev. time between licks in bursts	2.2	2.7	5.4	1.0	-1.2	-2.3
Total sessions with >9 infusions	1.5	1.6	3.0	1.7	-1.2	0.6
Short access day 1 total inactive lever presses	0.2	0.2	0.5	-0.7	0.2	-0.2
Short access day 10 total inactive lever presses	0.5	0.5	1.0	-1.0	0.8	0.1
Short access day 1 total infusions	1.1	1.2	1.7	1.3	-1.2	-0.5
Short access day 10 total infusions	0.7	0.8	1.3	1.1	-1.0	-0.4
Short access total infusions	1.0	1.1	1.6	1.2	-1.3	-0.5
Short access day 1 locomotion	0.5	0.6	1.2	0.6	-0.4	1.1
Short access day 10 total locomotion	0.2	0.2	0.4	-0.1	0.4	0.6
Short access total locomotion	0.3	0.3	0.8	-0.0	0.4	0.9
One hour access (0.3 mA shock)	0.3	0.3	0.6	0.8	-0.6	-0.1
Compulsive drug intake	0.3	0.3	0.5	-0.5	0.3	0.7
One hour access (shock baseline)	0.5	0.6	0.8	0.9	-0.7	-0.7
Social response proportion	0.4	0.4	1.0	-0.5	0.2	-1.0
Social responses	0.6	0.8	2.0	-0.6	0.3	-1.4
Social time	2.7	3.5	4.3	-1.9	2.1	1.7
Soleus weight	0.4	1.1	2.9	-0.6	0.4	-1.7
Bone: stiffness	0.5	0.8	1.8	-0.7	0.4	-1.4
Tibialis anterior weight	0.2	0.5	1.3	0.3	-0.4	-1.2
Time to tail flick, vehicle, before self-admin	0.7	0.8	1.0	0.7	-1.0	-0.9
Time to tail flick, vehicle, after self-admin	1.2	1.2	2.0	1.4	-1.3	-0.2
Time to tail flick, test, before self-admin	2.3	2.3	3.3	1.6	-1.8	-1.0
Time to tail flick, test, after self-admin	3.9	4.0	5.9	1.5	-1.9	-2.4
Delta time to tail flick, vehicle, before/after SA	0.3	0.3	0.6	0.5	-0.1	0.8
Delta time to tail flick, test, before/after SA	0.3	0.2	0.5	-0.3	0.2	-0.7
Tibia length	0.4	1.0	1.6	1.3	-1.2	0.2
Ambulatory time before self-admin	1.0	1.0	1.1	-1.0	1.1	1.0
Ambulatory time after self-admin	0.3	0.3	0.4	0.6	-0.4	0.7
Bone: tissue strength	1.2	1.2	2.9	-0.5	0.7	1.7
Total heroin consumption	0.5	0.6	1.0	1.0	-0.9	-0.3
Bone: trabecular number	1.9	2.9	4.1	-1.4	1.7	2.0
Bone: trabecular spacing	0.4	0.5	0.7	0.9	-0.8	0.0
Bone: trabecular thickness	0.2	0.3	0.8	-0.2	0.1	-0.9
Bone: trabecular tissue density	1.2	1.7	3.5	-1.0	0.7	-1.9
Water consumed over 24 hours	0.5	0.7	0.9	-0.9	0.9	0.5
Number of responses in last shaping day	0.1	0.1	0.1	-0.2	0.2	-0.3