LOC134484907

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	BLA	gene expression	LOC134484907	0.07	0.05	5.0e-03	0.03	0.04	0.03	0.03	1.1e-02	5.0e-03	7.1e-03	8.8e-03
2	IC	gene expression	LOC134484907	0.22	0.12	7.8e-08	0.07	0.14	0.14	0.12	4.8e-04	1.3e-06	2.5e-06	1.0e-05
3	OFC	gene expression	LOC134484907	0.39	0.16	3.1e-07	0.25	0.28	0.27	0.27	1.4e-06	2.8e-07	4.4e-07	4.5e-07
4	PL	gene expression	LOC134484907	0.13	0.06	2.3e-15	0.15	0.15	0.15	0.15	3.9e-16	1.9e-16	2.3e-16	3.5e-16
5	Brain	gene expression	LOC134484907	0.06	0.04	5.5e-05	0.03	0.02	0.03	0.02	2.1e-03	2.2e-03	2.1e-03	2.3e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5
Bone: apparent density	0.1	0.1	0.2	0.3	0.3	0.3	0.5	-0.2
Area under the delay curve	0.2	0.3	0.5	-0.4	-0.4	-0.4	-0.5	0.7
BMI with tail	1.0	3.6	5.4	1.5	1.7	2.0	1.9	-2.3
BMI without tail	0.7	3.6	6.1	1.2	1.6	2.0	2.0	-2.5
Body weight	0.9	3.8	5.7	1.3	1.7	2.1	2.0	-2.4
Weight adjusted by age	0.1	0.2	0.3	0.2	0.3	0.4	0.4	-0.5
Bone surface	0.6	1.1	1.8	-1.4	-1.2	-1.0	-0.8	0.9
Bone volume	0.1	0.1	0.3	-0.5	-0.4	-0.2	-0.0	0.1
Breakpoint value in progressive ratio session	0.1	0.2	0.5	0.7	0.5	0.4	0.3	-0.3
Number of licking bursts	1.8	5.6	6.3	2.5	2.5	2.4	2.3	-2.1
Context. condit. distance diff. score	2.3	2.8	3.3	-1.8	-1.8	-1.7	-1.6	1.5
Locomotion velocity, session 1	0.1	0.1	0.2	0.0	-0.1	-0.3	-0.4	0.3
Locomotion distance, session 1	1.0	1.3	1.7	-1.0	-1.1	-1.1	-1.3	1.1
Locomotion velocity, session 2	0.0	0.0	0.1	-0.2	-0.2	-0.2	-0.3	0.2
Locomotion distance, session 2	0.2	0.3	0.4	-0.5	-0.5	-0.5	-0.6	0.6
Locomotion velocity, session 3	0.3	0.3	0.4	-0.5	-0.6	-0.6	-0.6	0.5
Locomotion distance, session 3	1.1	1.3	1.6	-1.0	-1.1	-1.2	-1.3	1.1
Stereotopy head waving bouts, day 3	0.6	0.7	0.8	0.8	0.9	0.9	0.9	-0.8
Stereotopy head waving duration, day 3	0.3	0.4	0.4	-0.6	-0.6	-0.6	-0.6	0.6
Locomotion velocity, session 7	0.2	0.2	0.3	0.5	0.5	0.4	0.4	-0.4
Locomotion distance, session 7	0.2	0.2	0.2	0.4	0.4	0.5	0.4	-0.4
Stereotopy head waving bouts, day 7	2.6	3.0	3.2	-1.7	-1.7	-1.8	-1.7	1.7
Stereotopy head waving duration, day 7	2.6	3.2	3.5	-1.9	-1.8	-1.8	-1.7	1.7
Locomotion velocity, session 8	2.2	2.6	2.9	-1.7	-1.6	-1.6	-1.5	1.6
Locomotion distance, session 8	2.0	2.8	3.0	-1.7	-1.7	-1.7	-1.7	1.6
Degree of sensitization distance	1.1	1.2	1.5	0.9	1.0	1.2	1.2	-1.1
Degree of sensitization stereotypy	5.8	6.4	6.6	-2.5	-2.5	-2.6	-2.6	2.5
Conditioned locomotion	0.0	0.0	0.0	-0.0	-0.1	-0.2	-0.2	0.2
Cocaine response after cond. corrected	1.0	1.5	1.7	1.3	1.3	1.3	1.1	-1.0
Cocaine response after cond. not corrected	0.1	0.1	0.2	0.5	0.4	0.4	0.2	-0.1
Cocaine response before conditioning	2.2	2.7	2.9	-1.6	-1.6	-1.7	-1.6	1.7
Saline control response	1.2	1.7	2.2	-1.5	-1.3	-1.2	-1.3	1.2
Bone: connectivity density	0.2	0.3	0.4	-0.6	-0.6	-0.6	-0.4	0.5
Bone: cortical apparent density	1.0	1.6	1.8	1.3	1.3	1.3	1.2	-1.1
Bone: cortical area	0.0	0.0	0.1	-0.1	0.0	0.2	0.3	-0.1
Bone: cortical porosity	1.4	1.5	1.7	-1.0	-1.2	-1.2	-1.3	1.3
Bone: cortical porosity	1.3	1.4	1.6	-1.0	-1.1	-1.2	-1.3	1.3
Bone: cortical thickness	0.5	0.8	0.9	1.0	0.9	0.9	0.9	-0.6
Bone: cortical thickness	0.0	0.0	0.1	-0.1	-0.1	-0.0	-0.2	0.3
Bone: cortical tissue density	0.9	1.4	1.6	1.3	1.3	1.2	1.2	-1.0
Condit. Reinf. active minus inactive responses	0.4	0.5	1.0	0.4	0.5	0.7	0.7	-1.0
Condit. Reinf. active-inactive response ratio	0.1	0.1	0.3	-0.1	0.0	0.2	0.4	-0.6
Condit. Reinf. active responses	0.5	0.7	1.1	0.7	0.7	0.8	0.8	-1.1
Condit. Reinf. inactive responses	0.2	0.2	0.3	0.6	0.5	0.5	0.4	-0.4
Incentive salience index mean	0.4	0.5	1.0	0.4	0.5	0.7	0.7	-1.0
Condit. Reinf. lever presses	0.0	0.0	0.1	0.1	0.1	0.1	0.2	-0.3
Condit. Reinf. active minus inactive responses	3.4	5.2	7.0	-2.6	-2.4	-2.1	-2.2	2.0
Condit. Reinf. active-inactive response ratio	0.3	0.4	0.6	-0.7	-0.7	-0.6	-0.7	0.5
Condit. Reinf. active responses	5.4	7.7	10.7	-3.3	-3.0	-2.5	-2.6	2.4
Condit. Reinf. inactive responses	2.8	4.2	6.1	-2.5	-2.2	-1.9	-1.9	1.7
Condit. Reinf. lever presses	17.5	25.3	30.8	-5.5	-5.2	-4.9	-4.9	4.6
Condit. Reinf. lever reinforcers received	6.5	9.0	12.3	-3.5	-3.2	-2.8	-2.9	2.6
Conditioned reinforcement - actives	0.5	2.0	2.1	-1.4	-1.4	-1.4	-1.4	1.3
Conditioned reinforcement - inactives	0.0	0.1	0.2	0.0	-0.1	-0.3	-0.3	0.4
Conditioned locomotion	2.9	4.3	4.8	-1.9	-2.0	-2.1	-2.2	2.2
Patch foraging indifference point 0 sec	2.8	8.0	9.7	-3.1	-3.0	-2.8	-2.7	2.5
Patch foraging indifference point AUC	0.0	0.0	0.1	-0.1	0.0	0.1	0.2	-0.3
Delay disc. indifference point, 0s delay	0.7	0.8	0.9	-0.9	-0.9	-0.8	-0.9	1.0
Delay disc. indifference point, 16s delay	0.0	0.0	0.1	-0.1	-0.1	-0.2	-0.2	0.4
Delay disc. indifference point, 2s delay	1.7	1.8	2.2	-1.3	-1.3	-1.3	-1.4	1.5
Delay disc. indifference point, 24s delay	0.6	1.0	1.1	1.0	1.1	1.0	1.0	-0.8
Delay disc. indifference point, 4s delay	0.3	0.3	0.4	-0.6	-0.5	-0.4	-0.6	0.5
Delay disc. indifference point, 8s delay	0.3	0.5	0.7	-0.7	-0.7	-0.7	-0.6	0.8
Indifference point function ln k	1.1	3.2	3.5	-1.6	-1.8	-1.8	-1.8	1.9
Indifference point function log k	1.1	3.2	3.5	-1.6	-1.8	-1.8	-1.8	1.9
Patch foraging total patch changes 0 sec	2.4	7.0	8.5	-2.9	-2.8	-2.6	-2.5	2.4
Patch foraging total patch changes 12 sec	0.4	0.5	1.1	-1.0	-0.8	-0.6	-0.5	0.4
Patch foraging total patch changes 18 sec	0.5	1.2	2.1	-1.5	-1.3	-1.0	-0.9	0.7
Patch foraging total patch changes 24 sec	0.0	0.1	0.3	-0.5	-0.4	-0.3	-0.4	0.2
Patch foraging total patch changes 6 sec	1.5	2.6	3.0	-1.7	-1.7	-1.6	-1.5	1.5
Patch foraging time to switch 0 sec	1.3	4.9	6.5	2.5	2.3	2.1	2.0	-1.9
Patch foraging water rate 0 sec	1.4	5.1	6.3	-2.5	-2.4	-2.2	-2.2	2.0
Patch foraging water rate 12 sec	0.8	3.3	3.6	-1.9	-1.9	-1.8	-1.8	1.7
Patch foraging water rate 18 sec	0.2	0.5	0.7	-0.9	-0.8	-0.7	-0.7	0.6
Patch foraging water rate 24 sec	1.5	2.1	2.3	-1.4	-1.5	-1.5	-1.5	1.4
Patch foraging water rate 6 sec	1.0	1.5	1.7	-1.2	-1.2	-1.3	-1.2	1.3
Seeking ratio, delayed vs. immediate footshock	1.8	2.5	3.0	1.7	1.7	1.5	1.5	-1.5
Distance traveled before self-admin	0.2	0.4	0.4	0.6	0.6	0.6	0.6	-0.5
Distance traveled after self-admin	0.1	0.2	0.5	0.7	0.5	0.3	0.2	-0.1
Extensor digitorum longus weight	0.4	1.7	2.5	0.9	1.2	1.4	1.5	-1.6
Bone: elastic displacement	0.7	0.9	1.3	1.1	1.0	0.9	0.9	-0.7
Bone: elastic work	0.6	0.7	1.2	1.1	1.0	0.7	0.9	-0.6
Bone: endosteal estimation	0.1	0.3	0.8	-0.9	-0.6	-0.3	-0.2	0.0
Bone: endosteal perimeter	0.6	1.4	2.6	-1.6	-1.3	-1.0	-0.9	0.8
Epididymis fat weight	0.7	3.8	4.4	1.9	1.9	2.0	1.9	-2.1
Delta time in closed arm before/after self-admin	1.8	1.7	2.0	1.2	1.3	1.3	1.4	-1.3
Delta time in open arm before/after self-admin	1.3	1.5	2.3	-1.5	-1.3	-1.2	-1.1	1.0
Diff in mean of infusions in LGA sessions	3.0	5.4	7.0	2.7	2.5	2.3	2.2	-2.0
Delay discount exponential model param	0.2	0.2	0.5	0.4	0.4	0.4	0.5	-0.7
Extinction: sum of active levers before priming	0.0	0.0	0.0	0.1	0.1	0.2	0.1	-0.1
Active lever presses in extinction session 6	5.8	5.8	6.6	-2.1	-2.3	-2.5	-2.5	2.6
Bone: final force	0.0	0.1	0.2	-0.2	-0.2	-0.2	-0.1	0.4
Bone: final moment	0.1	0.1	0.2	-0.3	-0.3	-0.3	-0.2	0.5
Food consumed during 24 hour testing period	2.4	4.8	4.9	-2.2	-2.1	-2.2	-2.2	2.2
Glucose	0.1	0.2	0.3	0.3	0.3	0.4	0.3	-0.6
Heart weight	0.6	0.9	1.1	-1.1	-1.0	-0.9	-0.9	0.8
Delay discount hyperbolic model param	0.2	0.2	0.5	0.4	0.4	0.4	0.5	-0.7
Intermittent access intake day 1-15 change	0.8	4.2	4.7	-1.9	-2.0	-2.0	-2.1	2.2
Intermittent access intake escalation	0.9	4.7	5.2	-2.1	-2.1	-2.2	-2.2	2.3
Intermittent access intake escalation 2	1.4	2.4	2.5	-1.5	-1.6	-1.6	-1.5	1.6
Intermitt. access day 1 inactive lever presses	0.1	1.4	2.0	1.4	1.3	1.1	1.1	-0.9
Intermitt. access day 15 inactive lever presses	0.2	1.2	1.9	1.4	1.2	1.1	1.0	-0.8
Intermitt. access escalation Index	0.0	0.0	0.0	0.0	0.0	-0.0	0.1	0.1
Intermittent access day 1 total infusions	0.3	0.8	1.0	-1.0	-0.9	-0.9	-0.9	0.8
Intermittent access day 15 total infusions	1.9	4.7	5.0	-2.1	-2.1	-2.2	-2.1	2.2
Intermittent access terminal intake (last 3 days)	2.2	3.8	3.9	-2.0	-2.0	-1.9	-1.9	2.0
Intermittent access total infusions	1.3	1.5	1.8	-1.3	-1.3	-1.2	-1.1	1.1
Intermittent access day 1 locomotion	0.2	0.4	0.4	-0.6	-0.6	-0.7	-0.6	0.6
Intermittent access day 15 total locomotion	0.9	3.4	3.6	-1.8	-1.8	-1.9	-1.9	1.9
Intermittent access total locomotion	1.0	1.2	1.3	-1.1	-1.1	-1.1	-1.1	1.1
Intermittent access standard deviation	0.0	0.0	0.0	-0.2	-0.1	0.1	0.1	-0.2
Left kidney weight	0.1	0.8	1.5	0.5	0.7	1.0	1.0	-1.2
Right kidney weight	0.1	0.7	1.5	0.3	0.6	1.0	0.9	-1.2
Cocaine induced anxiety	0.9	2.5	2.6	1.6	1.6	1.5	1.6	-1.5
Post-drug Anxiety	1.6	1.8	2.0	1.4	1.4	1.3	1.4	-1.2
Baseline Anxiety	0.2	0.3	0.4	-0.6	-0.6	-0.5	-0.5	0.6
Tail length	0.3	1.5	2.6	0.5	0.9	1.3	1.4	-1.6
Length with tail	0.3	1.2	2.0	0.5	0.8	1.2	1.2	-1.4
Length without tail	0.1	0.4	0.5	0.7	0.7	0.7	0.5	-0.4
Times rat made contact with spout	0.8	0.9	1.2	0.8	0.9	1.0	1.1	-1.0
Lifetime Intake	1.8	2.2	2.5	-1.6	-1.5	-1.5	-1.4	1.4
Liver weight, left	0.6	1.1	1.3	0.8	1.0	1.1	1.0	-1.1
Liver weight, right	3.5	6.0	7.0	2.2	2.4	2.6	2.4	-2.6
Locomotor activity	0.5	0.8	1.1	-1.1	-1.0	-0.9	-0.8	0.7
Locomotor testing distance	0.3	0.7	1.3	-1.2	-0.9	-0.7	-0.7	0.5
Locomotor testing rearing	0.0	0.2	0.5	-0.1	0.1	0.4	0.4	-0.7
Locomotion in novel chamber	1.3	1.8	1.9	-1.3	-1.3	-1.4	-1.4	1.3
Locomotion in novel chamber post-restriction	2.2	6.5	6.7	-2.5	-2.6	-2.6	-2.6	2.5
Fecal boli incidents, locomotor time 1	0.5	1.4	1.4	-1.1	-1.1	-1.2	-1.2	1.2
Change in fecal boli incidents, locomotor task	0.5	0.5	0.6	0.8	0.7	0.7	0.6	-0.7
Time >=10cm from walls, locomotor time 1	2.6	3.2	3.4	-1.7	-1.8	-1.9	-1.8	1.7
Bouts of movement, locomotor time 1	0.1	0.1	0.1	-0.3	-0.3	-0.3	-0.4	0.3
Total resting periods, locomotor time 1	0.1	0.1	0.1	-0.2	-0.2	-0.3	-0.4	0.4
Rest time, locomotor task time 1	0.0	0.0	0.1	0.1	0.0	-0.2	-0.3	0.3
Distance moved, locomotor task time 1	0.0	0.1	0.3	-0.0	0.1	0.3	0.5	-0.5
Vertical activity count, locomotor time 1	0.0	0.1	0.3	-0.5	-0.4	-0.2	-0.0	0.0
Time >=10cm from walls, locomotor time 2	0.3	0.7	0.9	-0.9	-0.9	-0.8	-0.9	0.7
Bouts of movement, locomotor time 2	0.2	0.5	0.7	-0.8	-0.7	-0.7	-0.8	0.5
Total resting periods, locomotor time 2	0.1	0.3	0.4	-0.6	-0.6	-0.5	-0.6	0.5
Rest time, locomotor task time 2	0.9	1.5	2.0	1.4	1.3	1.2	1.2	-1.0
Distance moved, locomotor task time 2	1.0	1.3	1.9	-1.4	-1.2	-1.0	-1.1	0.9
Vertical activity count, locomotor time 2	0.1	0.3	0.6	-0.8	-0.7	-0.4	-0.4	0.3
Light reinforcement 1	0.6	2.7	3.0	1.7	1.7	1.7	1.6	-1.4
Light reinforcement 2	0.1	0.1	0.3	-0.1	-0.2	-0.2	-0.4	0.6
Bone: marrow area	0.1	0.2	0.6	-0.8	-0.5	-0.2	-0.1	-0.1
Bone: maximum diameter	0.7	1.4	2.4	-1.5	-1.3	-1.0	-0.9	1.0
Bone: maximum force	0.1	0.3	0.4	-0.5	-0.5	-0.5	-0.4	0.7
Bone: maximum moment	0.2	0.3	0.5	-0.6	-0.6	-0.5	-0.4	0.7
Mean time between licks in bursts	0.3	1.5	2.7	-1.6	-1.3	-1.0	-1.1	1.0
Mean num. licks in bursts	1.5	4.0	4.8	-2.2	-2.1	-2.0	-1.9	1.8
Cd content in liver	1.5	1.7	2.1	1.2	1.2	1.3	1.3	-1.5
Co content in liver	0.1	0.1	0.2	-0.5	-0.3	-0.2	-0.1	-0.1
Cu content in liver	0.5	0.5	0.8	0.5	0.7	0.9	0.7	-0.8
Fe content in liver	0.0	0.0	0.1	0.1	0.1	0.1	0.0	0.3
K content in liver	0.1	0.1	0.1	0.3	0.4	0.3	0.3	-0.3
Mg content in liver	0.2	0.2	0.2	-0.4	-0.4	-0.4	-0.5	0.3
Mn content in liver	0.1	0.1	0.2	0.4	0.2	0.0	-0.1	0.2
Na content in liver	1.7	1.9	2.2	-1.3	-1.3	-1.4	-1.4	1.5
Rb content in liver	0.0	0.0	0.0	-0.2	-0.1	-0.0	0.1	-0.1
Se content in liver	3.3	3.9	5.8	2.4	2.2	1.9	1.7	-1.6
Sr content in liver	0.2	0.2	0.3	-0.4	-0.5	-0.5	-0.5	0.3
Zn content in liver	0.5	0.5	1.0	-1.0	-0.8	-0.6	-0.7	0.4
Bone: minimum diameter	0.3	0.6	0.9	0.3	0.6	0.8	1.0	-1.0
Time in familiar zone, hab. session 1	0.1	0.2	0.2	0.4	0.4	0.4	0.4	-0.3
Time in novel zone, hab. session 1	0.2	0.2	0.3	0.4	0.4	0.4	0.4	-0.5
Total zone transitions, hab. session 1	0.6	0.9	1.3	-0.8	-0.9	-1.0	-0.9	1.2
Total locomotion distance, hab. session 1	2.2	3.1	3.4	1.6	1.7	1.8	1.8	-1.8
Locomotion velocity, hab. session 1	1.4	2.0	2.2	1.3	1.4	1.5	1.5	-1.4
Time in familiar zone, hab. session 2	0.3	0.4	0.7	-0.8	-0.7	-0.6	-0.4	0.4
Time in novel zone, hab. session 2	0.1	0.1	0.2	0.4	0.3	0.2	0.0	-0.2
Total zone transitions, hab. session 2	2.3	2.9	3.6	-1.5	-1.6	-1.7	-1.8	1.9
Total locomotion distance, hab. session 2	0.7	0.9	1.2	0.8	0.9	1.1	1.0	-0.9
Locomotion velocity, hab. session 2	0.9	1.2	1.5	0.9	1.1	1.2	1.1	-1.0
Novel to familiar place preference ratio	0.2	0.2	0.3	-0.4	-0.4	-0.4	-0.6	0.4
Novelty place preference	0.1	0.1	0.2	-0.2	-0.3	-0.3	-0.4	0.2
Time in novel zone, NPP test	0.2	0.2	0.3	-0.4	-0.5	-0.5	-0.6	0.4
Total zone transitions, NPP test	0.4	0.7	1.0	-0.6	-0.7	-0.8	-0.9	1.0
Total locomotion distance, NPP test	1.8	2.5	2.9	1.6	1.6	1.7	1.4	-1.5
Locomotion velocity, NPP test	2.3	3.4	3.9	1.9	1.9	2.0	1.7	-1.7
Intraocular pressure	0.8	1.3	1.6	-1.1	-1.2	-1.3	-1.2	0.8
Delta distance traveled before/after self-admin	1.1	1.2	1.6	-0.9	-1.0	-1.1	-1.2	1.3
Delta ambulatory time before/after self-admin	0.8	1.3	1.6	-0.9	-1.1	-1.2	-1.2	1.3
Parametrial fat weight	0.3	0.8	0.9	0.9	0.9	0.9	0.9	-0.9
Pavlov. Cond. lever latency	0.4	0.6	0.9	0.9	0.8	0.7	0.6	-0.6
Pavlov. Cond. magazine entry latency	1.6	2.0	3.0	-1.7	-1.5	-1.3	-1.3	1.1
Pavlov. Cond. change in total contacts	0.4	0.4	0.6	-0.8	-0.7	-0.6	-0.7	0.6
Pavlov. Cond. index score	0.8	1.0	1.7	-1.3	-1.1	-0.9	-0.8	0.7
Pavlov. Cond. latency score	0.8	1.1	1.7	-1.3	-1.1	-1.0	-0.9	0.7
Pavlov. Cond. lever contacts	0.1	0.2	0.4	-0.6	-0.5	-0.4	-0.3	0.2
Pavlov. Cond. magazine entry number	1.4	1.7	2.6	1.6	1.5	1.2	1.2	-1.0
Pavlov. Cond. intertrial magazine entries	1.9	2.3	2.8	1.7	1.6	1.5	1.3	-1.4
Pavlov. Cond. lever-magazine prob. diff.	0.6	0.8	1.3	-1.2	-1.0	-0.8	-0.7	0.6
Pavlov. Cond. response bias	0.2	0.3	0.6	-0.8	-0.6	-0.5	-0.4	0.3
Pavlov. Cond. lever latency	20.8	29.2	34.2	5.8	5.6	5.3	5.3	-5.0
Pavlov. Cond. magazine entry latency	6.0	8.6	9.3	-3.0	-3.0	-2.9	-2.8	2.8
Pavlov. Cond. change in total contacts	7.7	18.6	21.7	-4.7	-4.5	-4.2	-4.3	3.9
Pavlov. Cond. index score	13.7	21.5	25.1	-5.0	-4.8	-4.5	-4.5	4.2
Pavlov. Cond. latency score	12.5	20.0	22.9	-4.8	-4.6	-4.4	-4.4	4.1
Pavlov. Cond. lever contacts	18.1	26.7	31.6	-5.6	-5.4	-5.0	-5.0	4.7
Pavlov. Cond. magazine entry number	7.7	10.0	11.2	3.3	3.3	3.1	3.2	-2.9
Pavlov. Cond. intertrial magazine entries	0.3	0.6	0.9	0.5	0.7	0.9	0.8	-1.0
Pavlov. Cond. lever-magazine prob. diff.	12.7	19.5	22.9	-4.8	-4.6	-4.3	-4.3	4.0
Pavlov. Cond. response bias	19.4	26.9	31.8	-5.6	-5.4	-5.1	-5.0	4.7
Time in closed arm before self-admin	0.8	1.4	1.5	-1.1	-1.2	-1.2	-1.2	1.2
Time in closed arm after self-admin	0.1	0.2	0.4	0.6	0.5	0.3	0.3	-0.1
Time in open arm before self-admin	1.9	2.3	2.8	1.7	1.6	1.5	1.4	-1.4
Time in open arm after self-admin	0.0	0.0	0.1	-0.3	-0.1	0.0	0.1	-0.3
Bone: periosteal estimation	0.1	0.2	0.6	-0.8	-0.5	-0.2	-0.1	0.1
Bone: periosteal perimeter	0.2	0.5	1.1	-1.1	-0.8	-0.5	-0.4	0.4
Bone: post-yield work	0.2	0.3	0.5	-0.7	-0.6	-0.6	-0.3	0.5
Progressive ratio test 1 active lever presses	0.1	0.1	0.3	-0.1	-0.2	-0.4	-0.3	0.5
Progressive ratio test 1 breakpoint	0.1	0.1	0.3	-0.1	-0.2	-0.3	-0.3	0.5
Progressive ratio test 1 inactive lever presses	0.0	0.0	0.1	0.2	0.1	0.0	0.1	0.1
Progressive ratio test 2 active lever presses	0.4	0.5	0.7	-0.8	-0.8	-0.7	-0.7	0.6
Progressive ratio test 2 breakpoint	0.5	0.6	0.7	-0.8	-0.8	-0.7	-0.7	0.6
Progressive ratio test 2 inactive lever presses	0.1	0.2	0.2	-0.5	-0.5	-0.4	-0.4	0.4
Incentive Sensitization - Responses	0.4	1.0	1.5	-1.2	-1.1	-1.0	-0.9	0.8
Incentive Sensitization - Breakpoint	0.4	1.0	1.4	-1.2	-1.1	-0.9	-0.9	0.8
Sum of active levers in priming session hrs 5-6	0.1	0.1	0.1	-0.2	-0.2	-0.2	-0.4	0.3
Progressive ratio	0.2	0.7	0.8	-0.8	-0.8	-0.8	-0.8	0.9
Food seeking constrained by brief footshock	1.4	1.7	2.4	-1.6	-1.4	-1.2	-1.2	1.0
Seeking ratio, punishment vs. effort	0.0	0.0	0.2	-0.4	-0.2	-0.0	-0.0	-0.1
Retroperitoneal fat weight	4.3	19.1	22.1	3.9	4.2	4.6	4.5	-4.7
Reaction time number correct	0.2	0.8	1.0	-0.7	-0.8	-1.0	-1.0	1.0
Reaction time mean minus median	0.1	0.8	1.3	-1.1	-1.0	-0.8	-0.8	0.6
Reaction time mean minus median AUC	0.2	1.6	2.0	-1.4	-1.3	-1.2	-1.2	1.1
Reaction time num false alarms	2.5	4.2	4.4	2.1	2.1	2.1	2.1	-2.0
Reaction time num false alarms AUC	1.0	2.3	2.5	1.6	1.6	1.5	1.5	-1.4
Reaction time trials correct on left	0.2	0.8	1.0	-0.7	-0.8	-1.0	-1.0	1.0
Reaction time trials on left	0.3	0.9	1.1	-0.7	-0.8	-1.0	-1.0	1.0
Reaction time mean	0.2	0.5	0.5	0.6	0.7	0.7	0.7	-0.7
Reaction time mean AUC	0.3	0.8	0.8	0.9	0.9	0.9	0.9	-0.9
Median of all reaction times	0.6	0.9	1.0	0.9	1.0	1.0	1.0	-0.9
Reaction time omissions	0.0	0.0	0.0	-0.1	0.0	0.1	-0.0	-0.1
Reaction time false alarm rate	2.5	3.4	3.6	1.8	1.9	1.9	1.9	-1.8
Reaction time premature initiation rate	0.1	0.1	0.4	-0.6	-0.3	0.0	0.2	-0.3
Reaction time premature initiations	0.2	0.5	1.1	-1.1	-0.8	-0.6	-0.5	0.3
Std. dev. reaction times	0.0	0.0	0.1	-0.3	-0.1	0.1	0.1	-0.3
Reaction time trials completed	0.3	0.9	1.1	-0.7	-0.8	-1.0	-1.0	1.0
Reaction time trials AUC	0.2	0.8	1.0	-0.7	-0.8	-0.9	-1.0	0.9
Run reversals in cocaine runway, females	2.3	2.6	3.6	1.2	1.4	1.7	1.8	-1.9
Run reversals in cocaine runway, males	0.1	0.1	0.1	-0.3	-0.2	-0.3	-0.3	0.3
Latency to leave start box in cocaine runway	1.9	2.7	3.1	1.7	1.7	1.6	1.5	-1.5
Latency to leave start box in cocaine runway, F	2.8	3.5	3.8	1.9	1.9	1.9	1.8	-1.8
Latency to leave start box in cocaine runway, M	0.0	0.0	0.1	0.2	0.2	0.0	0.0	-0.1
Std. dev. time between licks in bursts	0.0	0.0	0.2	-0.4	-0.2	0.0	0.0	-0.2
Total sessions with >9 infusions	2.2	2.7	3.0	-1.7	-1.7	-1.6	-1.6	1.6
Short access day 1 total inactive lever presses	0.0	0.1	0.2	-0.2	-0.2	-0.3	-0.3	0.5
Short access day 10 total inactive lever presses	0.2	1.2	1.5	1.2	1.1	1.0	1.0	-1.0
Short access day 1 total infusions	1.5	3.0	3.8	-1.9	-1.8	-1.7	-1.6	1.7
Short access day 10 total infusions	0.7	1.1	1.3	-1.1	-1.1	-1.0	-1.0	1.1
Short access total infusions	1.9	2.7	2.9	-1.7	-1.7	-1.6	-1.6	1.7
Short access day 1 locomotion	3.3	5.4	5.6	-2.3	-2.4	-2.4	-2.3	2.3
Short access day 10 total locomotion	0.5	1.8	2.1	-1.5	-1.4	-1.3	-1.3	1.2
Short access total locomotion	1.3	1.9	2.0	-1.3	-1.4	-1.4	-1.3	1.4
One hour access (0.3 mA shock)	0.8	1.0	1.3	-1.1	-1.1	-1.0	-1.0	0.8
Compulsive drug intake	0.0	0.0	0.1	0.2	0.0	-0.1	-0.2	0.1
One hour access (shock baseline)	0.8	2.1	2.4	-1.6	-1.5	-1.4	-1.4	1.4
Social response proportion	0.7	0.9	1.0	1.0	1.0	1.0	1.0	-0.8
Social responses	1.8	2.3	2.5	1.4	1.5	1.6	1.6	-1.6
Social time	1.8	2.8	3.9	2.0	1.8	1.6	1.4	-1.4
Soleus weight	1.0	2.8	3.8	1.3	1.6	1.8	1.9	-1.7
Bone: stiffness	0.0	0.0	0.1	0.2	0.3	0.2	0.2	0.1
Tibialis anterior weight	0.0	0.0	0.1	-0.2	0.0	0.1	0.2	-0.2
Time to tail flick, vehicle, before self-admin	0.0	0.0	0.1	0.1	0.1	0.2	0.3	-0.2
Time to tail flick, vehicle, after self-admin	0.7	1.3	1.6	-1.3	-1.2	-1.1	-1.0	1.1
Time to tail flick, test, before self-admin	0.1	0.1	0.2	0.0	0.2	0.3	0.4	-0.4
Time to tail flick, test, after self-admin	0.2	0.2	0.4	0.3	0.4	0.5	0.5	-0.6
Delta time to tail flick, vehicle, before/after SA	1.9	2.0	2.1	-1.4	-1.4	-1.4	-1.4	1.4
Delta time to tail flick, test, before/after SA	0.1	0.1	0.2	0.5	0.4	0.3	0.2	-0.2
Tibia length	2.0	5.6	5.9	-2.3	-2.4	-2.4	-2.4	2.3
Ambulatory time before self-admin	0.1	0.2	0.4	0.6	0.5	0.4	0.4	-0.3
Ambulatory time after self-admin	0.1	0.1	0.2	0.3	0.0	-0.2	-0.3	0.4
Bone: tissue strength	0.2	0.2	0.5	-0.1	-0.3	-0.5	-0.4	0.7
Total heroin consumption	0.0	0.0	0.0	0.1	0.1	0.1	0.0	-0.1
Bone: trabecular number	0.5	1.0	1.3	1.1	1.0	0.9	1.1	-0.9
Bone: trabecular spacing	1.4	2.0	2.4	-1.4	-1.4	-1.4	-1.5	1.4
Bone: trabecular thickness	1.0	1.4	1.7	1.0	1.1	1.2	1.3	-1.2
Bone: trabecular tissue density	1.1	2.0	2.3	1.5	1.5	1.5	1.4	-1.2
Water consumed over 24 hours	0.5	0.9	1.1	1.0	1.0	0.9	1.0	-0.8
Number of responses in last shaping day	2.4	3.1	3.6	1.6	1.7	1.8	1.9	-1.9