Hub : Traits

Incentive Sensitization - Breakpoint

Tags: Behavior · Motivation · Progressive ratio

Project: p50_paul_meyer_2020

5 loci · 5 genes with independent associations · 5 total associated genes

Significant Loci

#	Chr	Start pos	End pos	# assoc genes	# joint models	Best TWAS P	Best GWAS P	Cond GWAS P	Joint genes
1	chr1	88613126	89913275	1	1	1.31e-08	7.43e-03	1.09e-01	Zfp575
2	chr2	144511896	145907690	1	1	6.27e-08	1.32e-01	5.49e-18	Mindy4b
3	chr5	118282290	119677504	1	1	1.35e-08	3.53e-01	1.00e+00	Atg4c
4	chr7	92127461	93066096	1	1	7.12e-09	6.06e-01	1.00e+00	Ndufb9
5	chr9	83390749	84777604	1	1	0.00e+00	3.33e-01	1.00e+00	Retreg2

Pleiotropic Associations

Trait	Chi2 ratio	# genes+	# genes++	% genes++	Corr	Corr P	Genes
BMI with tail	296.8	3	3	60	0	1.00e+00	Mindy4b Ndufb9 Retreg2
BMI without tail	19088.19	3	2	40	0	1.00e+00	Mindy4b Ndufb9 Retreg2
Body weight	8.05	3	2	40	0	1.00e+00	Mindy4b Ndufb9 Retreg2
Epididymis fat weight	18141.5	2	1	20	0	1.00e+00	Ndufb9 Retreg2
Glucose	186.74	3	1	20	0	1.00e+00	Atg4c Ndufb9 Retreg2
Heart weight	1536.76	2	1	20	0	1.00e+00	Ndufb9 Retreg2
Left kidney weight	18352.75	3	2	40	0	1.00e+00	Mindy4b Ndufb9 Retreg2
Right kidney weight	20206.48	2	2	40	0	1.00e+00	Ndufb9 Retreg2
Tail length	28919.24	1	1	20	0	1.00e+00	Retreg2
Length with tail	746.74	2	2	40	0	1.00e+00	Ndufb9 Retreg2
Length without tail	11812.29	4	1	20	1	1.93e-04	Mindy4b Ndufb9 Retreg2 Zfp575
Liver weight, left	1747.19	2	1	20	0	1.00e+00	Ndufb9 Retreg2
Liver weight, right	19.08	3	1	20	0	1.00e+00	Mindy4b Ndufb9 Retreg2
Parametrial fat weight	181.56	1	1	20	0	1.00e+00	Retreg2
Retroperitoneal fat weight	1316.13	3	2	40	0	1.00e+00	Atg4c Mindy4b Retreg2
Intraocular pressure	10386.52	1	1	20	0	1.00e+00	Retreg2
Extensor digitorum longus weight	540.26	2	1	20	0	1.00e+00	Mindy4b Retreg2
Soleus weight	12.63	2	1	20	0	1.00e+00	Ndufb9 Retreg2
Tibialis anterior weight	1158.38	1	1	20	0	1.00e+00	Retreg2
Tibia length	385.43	2	1	20	0	1.00e+00	Ndufb9 Retreg2
Number of licking bursts	67424.86	1	1	20	0	1.00e+00	Retreg2
Food consumed during 24 hour testing period	35509.41	1	1	20	0	1.00e+00	Retreg2
Times rat made contact with spout	41.61	2	1	20	0	1.00e+00	Ndufb9 Retreg2
Mean time between licks in bursts	55817.09	2	1	20	0	1.00e+00	Ndufb9 Retreg2
Mean num. licks in bursts	56750.08	1	1	20	0	1.00e+00	Retreg2
Std. dev. time between licks in bursts	29750.31	1	1	20	0	1.00e+00	Retreg2
Water consumed over 24 hours	34168.6	1	1	20	0	1.00e+00	Retreg2
Patch foraging indifference point 0 sec	19587.91	2	1	20	0	1.00e+00	Atg4c Retreg2
Patch foraging indifference point AUC	25072.33	2	1	20	0	1.00e+00	Ndufb9 Retreg2
Indifference point function ln k	27852.12	2	2	40	0	1.00e+00	Ndufb9 Retreg2
Indifference point function log k	27852.12	2	2	40	0	1.00e+00	Ndufb9 Retreg2
Patch foraging total patch changes 0 sec	20976.22	2	1	20	0	1.00e+00	Atg4c Retreg2
Patch foraging total patch changes 12 sec	788.55	3	2	40	0	1.00e+00	Atg4c Ndufb9 Retreg2
Patch foraging total patch changes 18 sec	13490.4	3	1	20	0	1.00e+00	Atg4c Ndufb9 Retreg2
Patch foraging total patch changes 24 sec	24966.79	3	2	40	0	1.00e+00	Mindy4b Ndufb9 Retreg2
Patch foraging total patch changes 6 sec	1954.82	4	2	40	-1	3.94e-04	Atg4c Mindy4b Ndufb9 Retreg2
Patch foraging time to switch 0 sec	33254.99	2	2	40	0	1.00e+00	Ndufb9 Retreg2
Patch foraging water rate 0 sec	30219.01	2	1	20	0	1.00e+00	Ndufb9 Retreg2
Patch foraging water rate 12 sec	70639.93	1	1	20	0	1.00e+00	Retreg2
Patch foraging water rate 18 sec	16866.98	2	1	20	0	1.00e+00	Ndufb9 Retreg2
Patch foraging water rate 24 sec	1033.47	1	1	20	0	1.00e+00	Retreg2
Patch foraging water rate 6 sec	219.86	4	2	40	0.99	1.45e-02	Atg4c Ndufb9 Retreg2 Zfp575
Locomotor testing distance	13837.71	2	1	20	0	1.00e+00	Ndufb9 Retreg2
Locomotor testing rearing	21135.22	3	1	20	0	1.00e+00	Mindy4b Ndufb9 Retreg2
Light reinforcement 1	22108.34	3	1	20	0	1.00e+00	Atg4c Mindy4b Retreg2
Light reinforcement 2	12249.52	3	1	20	0	1.00e+00	Mindy4b Ndufb9 Retreg2
Reaction time number correct	31744.5	2	2	40	0	1.00e+00	Ndufb9 Retreg2
Reaction time mean minus median	59977.3	2	1	20	0	1.00e+00	Ndufb9 Retreg2
Reaction time mean minus median AUC	62002.11	2	2	40	0	1.00e+00	Ndufb9 Retreg2
Reaction time num false alarms	15357.42	1	1	20	0	1.00e+00	Retreg2
Reaction time num false alarms AUC	35016.83	1	1	20	0	1.00e+00	Retreg2
Reaction time trials correct on left	31744.5	2	2	40	0	1.00e+00	Ndufb9 Retreg2
Reaction time trials on left	30449.82	2	2	40	0	1.00e+00	Ndufb9 Retreg2
Reaction time mean	9919.69	3	2	40	0	1.00e+00	Atg4c Mindy4b Retreg2
Reaction time mean AUC	12933.07	3	2	40	0	1.00e+00	Atg4c Mindy4b Retreg2
Median of all reaction times	2646.1	3	2	40	0	1.00e+00	Atg4c Mindy4b Retreg2
Reaction time omissions	2795.93	3	1	20	0	1.00e+00	Mindy4b Ndufb9 Retreg2
Reaction time false alarm rate	108.16	2	1	20	0	1.00e+00	Ndufb9 Retreg2
Reaction time premature initiation rate	4871.37	2	1	20	0	1.00e+00	Mindy4b Retreg2
Reaction time premature initiations	26874.85	2	1	20	0	1.00e+00	Mindy4b Retreg2
Std. dev. reaction times	20292.58	3	1	20	0	1.00e+00	Mindy4b Ndufb9 Retreg2
Reaction time trials completed	30449.82	2	2	40	0	1.00e+00	Ndufb9 Retreg2
Reaction time trials AUC	31071.82	2	1	20	0	1.00e+00	Ndufb9 Retreg2
Social response proportion	2935.42	3	1	20	0	1.00e+00	Atg4c Mindy4b Retreg2
Social responses	635.8	2	1	20	0	1.00e+00	Ndufb9 Retreg2
Social time	11650.06	1	1	20	0	1.00e+00	Retreg2
Conditioned locomotion	1400.08	1	1	20	0	1.00e+00	Retreg2
Cocaine response after cond. corrected	9569.48	2	1	20	0	1.00e+00	Atg4c Retreg2
Cocaine response after cond. not corrected	9290.03	2	1	20	0	1.00e+00	Atg4c Retreg2
Cocaine response before conditioning	655.41	1	1	20	0	1.00e+00	Retreg2
Saline control response	3160.68	1	1	20	0	1.00e+00	Retreg2
Condit. Reinf. active minus inactive responses	14521.56	1	1	20	0	1.00e+00	Retreg2
Condit. Reinf. active-inactive response ratio	14360.59	2	1	20	0	1.00e+00	Ndufb9 Retreg2
Condit. Reinf. active responses	2302.04	1	1	20	0	1.00e+00	Retreg2
Condit. Reinf. inactive responses	5447.51	2	1	20	0	1.00e+00	Mindy4b Retreg2
Condit. Reinf. lever presses	1935.17	2	1	20	0	1.00e+00	Ndufb9 Retreg2
Condit. Reinf. lever reinforcers received	469.54	1	1	20	0	1.00e+00	Retreg2
Pavlov. Cond. lever latency	2531.81	1	1	20	0	1.00e+00	Retreg2
Pavlov. Cond. magazine entry latency	13282.18	1	1	20	0	1.00e+00	Retreg2
Pavlov. Cond. change in total contacts	19909.31	2	1	20	0	1.00e+00	Ndufb9 Retreg2
Pavlov. Cond. index score	12744.53	1	1	20	0	1.00e+00	Retreg2
Pavlov. Cond. latency score	16150.81	1	1	20	0	1.00e+00	Retreg2
Pavlov. Cond. lever contacts	5331.08	1	1	20	0	1.00e+00	Retreg2
Pavlov. Cond. magazine entry number	2009.54	2	1	20	0	1.00e+00	Atg4c Retreg2
Pavlov. Cond. intertrial magazine entries	34989.79	1	1	20	0	1.00e+00	Retreg2
Pavlov. Cond. lever-magazine prob. diff.	11800.43	1	1	20	0	1.00e+00	Retreg2
Pavlov. Cond. response bias	1164.95	1	1	20	0	1.00e+00	Retreg2
Conditioned reinforcement - actives	33615.25	3	2	40	0	1.00e+00	Mindy4b Ndufb9 Retreg2
Conditioned reinforcement - inactives	21643.05	3	2	40	0	1.00e+00	Atg4c Ndufb9 Retreg2
Conditioned locomotion	3477.64	3	3	60	0	1.00e+00	Mindy4b Ndufb9 Retreg2
Intermittent access intake day 1-15 change	42631.37	3	1	20	0	1.00e+00	Atg4c Mindy4b Retreg2
Intermittent access intake escalation	42029.41	3	2	40	0	1.00e+00	Atg4c Mindy4b Retreg2
Intermittent access intake escalation 2	18090.71	2	1	20	0	1.00e+00	Mindy4b Retreg2
Intermitt. access day 1 inactive lever presses	90309.52	2	1	20	0	1.00e+00	Ndufb9 Retreg2
Intermitt. access day 15 inactive lever presses	61868.22	2	2	40	0	1.00e+00	Ndufb9 Retreg2
Intermitt. access escalation Index	31107.24	3	1	20	0	1.00e+00	Mindy4b Ndufb9 Retreg2
Intermittent access day 1 total infusions	22045.38	3	1	20	0	1.00e+00	Atg4c Mindy4b Retreg2
Intermittent access day 15 total infusions	24371.34	2	1	20	0	1.00e+00	Retreg2 Zfp575
Intermittent access terminal intake (last 3 days)	12404.64	2	1	20	0	1.00e+00	Retreg2 Zfp575
Intermittent access total infusions	97.41	2	1	20	0	1.00e+00	Retreg2 Zfp575
Intermittent access day 1 locomotion	17488.68	2	1	20	0	1.00e+00	Mindy4b Retreg2
Intermittent access day 15 total locomotion	42776.3	2	1	20	0	1.00e+00	Atg4c Retreg2
Intermittent access total locomotion	37.49	4	1	20	-0.86	1.39e-01	Mindy4b Ndufb9 Retreg2 Zfp575
Intermittent access standard deviation	113962.95	1	1	20	0	1.00e+00	Retreg2
Cocaine induced anxiety	23061.5	3	2	40	0	1.00e+00	Ndufb9 Retreg2 Zfp575
Post-drug Anxiety	1597.19	3	2	40	0	1.00e+00	Ndufb9 Retreg2 Zfp575
Baseline Anxiety	11237.13	3	2	40	0	1.00e+00	Mindy4b Ndufb9 Retreg2
Lifetime Intake	833.15	2	1	20	0	1.00e+00	Retreg2 Zfp575
Incentive Sensitization - Responses	14289.35	5	5	100	1	1.75e-07	Atg4c Mindy4b Ndufb9 Retreg2 Zfp575
Progressive ratio test 1 active lever presses	15996.07	2	1	20	0	1.00e+00	Ndufb9 Retreg2
Progressive ratio test 1 breakpoint	15154.62	2	1	20	0	1.00e+00	Ndufb9 Retreg2
Progressive ratio test 1 inactive lever presses	20749.19	3	2	40	0	1.00e+00	Atg4c Ndufb9 Retreg2
Progressive ratio test 2 active lever presses	3059.71	5	1	20	1	1.26e-07	Atg4c Mindy4b Ndufb9 Retreg2 Zfp575
Progressive ratio test 2 breakpoint	1716.87	5	1	20	1	1.36e-05	Atg4c Mindy4b Ndufb9 Retreg2 Zfp575
Progressive ratio test 2 inactive lever presses	36254.71	2	1	20	0	1.00e+00	Ndufb9 Retreg2
Total sessions with >9 infusions	499.81	4	1	20	1	4.57e-04	Atg4c Mindy4b Retreg2 Zfp575
Short access day 1 total inactive lever presses	9870.67	4	4	80	1	8.01e-04	Mindy4b Ndufb9 Retreg2 Zfp575
Short access day 10 total inactive lever presses	138842.31	1	1	20	0	1.00e+00	Retreg2
Short access day 1 total infusions	19195.42	2	1	20	0	1.00e+00	Retreg2 Zfp575
Short access day 10 total infusions	5682.82	4	2	40	1	8.87e-04	Atg4c Mindy4b Ndufb9 Retreg2
Short access total infusions	4396.25	2	1	20	0	1.00e+00	Mindy4b Retreg2
Short access day 1 locomotion	8284.43	3	2	40	0	1.00e+00	Ndufb9 Retreg2 Zfp575
Short access day 10 total locomotion	44107.69	2	2	40	0	1.00e+00	Mindy4b Retreg2
Short access total locomotion	6236.8	3	2	40	0	1.00e+00	Mindy4b Ndufb9 Retreg2
Compulsive drug intake	4677.41	4	1	20	1	1.00e-03	Mindy4b Ndufb9 Retreg2 Zfp575
One hour access (0.3 mA shock)	594.44	4	2	40	-0.98	1.50e-02	Mindy4b Ndufb9 Retreg2 Zfp575
One hour access (shock baseline)	27501.24	2	1	20	0	1.00e+00	Retreg2 Zfp575
Number of responses in last shaping day	4548.47	3	1	20	0	1.00e+00	Mindy4b Retreg2 Zfp575
Context. condit. distance diff. score	212.47	1	1	20	0	1.00e+00	Retreg2
Locomotion velocity, session 1	1769.63	2	1	20	0	1.00e+00	Ndufb9 Retreg2
Locomotion distance, session 1	1024.77	1	1	20	0	1.00e+00	Retreg2
Locomotion velocity, session 2	724.26	3	1	20	0	1.00e+00	Atg4c Mindy4b Retreg2
Locomotion distance, session 2	508.11	1	1	20	0	1.00e+00	Retreg2
Locomotion velocity, session 3	507.49	1	1	20	0	1.00e+00	Retreg2
Locomotion distance, session 3	4009.46	1	1	20	0	1.00e+00	Retreg2
Stereotopy head waving bouts, day 3	1361.96	1	1	20	0	1.00e+00	Retreg2
Stereotopy head waving duration, day 3	2872.44	1	1	20	0	1.00e+00	Retreg2
Locomotion velocity, session 7	292.79	1	1	20	0	1.00e+00	Retreg2
Locomotion distance, session 7	435.3	2	1	20	0	1.00e+00	Ndufb9 Retreg2
Stereotopy head waving bouts, day 7	1279.33	2	2	40	0	1.00e+00	Ndufb9 Retreg2
Stereotopy head waving duration, day 7	1081.37	2	2	40	0	1.00e+00	Ndufb9 Retreg2
Locomotion velocity, session 8	409.23	1	1	20	0	1.00e+00	Retreg2
Locomotion distance, session 8	147.88	1	1	20	0	1.00e+00	Retreg2
Degree of sensitization distance	3670.85	1	1	20	0	1.00e+00	Retreg2
Degree of sensitization stereotypy	1029.63	2	1	20	0	1.00e+00	Ndufb9 Retreg2
Condit. Reinf. active minus inactive responses	327.4	3	1	20	0	1.00e+00	Atg4c Mindy4b Retreg2
Condit. Reinf. active-inactive response ratio	88.36	3	1	20	0	1.00e+00	Atg4c Mindy4b Retreg2
Condit. Reinf. active responses	929.52	3	1	20	0	1.00e+00	Atg4c Mindy4b Retreg2
Condit. Reinf. inactive responses	2347.53	2	1	20	0	1.00e+00	Ndufb9 Retreg2
Incentive salience index mean	1776.71	2	1	20	0	1.00e+00	Atg4c Retreg2
Condit. Reinf. lever presses	5282.33	1	1	20	0	1.00e+00	Retreg2
Time in familiar zone, hab. session 1	11168.49	1	1	20	0	1.00e+00	Retreg2
Time in novel zone, hab. session 1	4621.25	2	1	20	0	1.00e+00	Atg4c Retreg2
Total zone transitions, hab. session 1	221.7	2	1	20	0	1.00e+00	Ndufb9 Retreg2
Total locomotion distance, hab. session 1	394.1	1	1	20	0	1.00e+00	Retreg2
Locomotion velocity, hab. session 1	266.96	1	1	20	0	1.00e+00	Retreg2
Time in familiar zone, hab. session 2	5880.03	1	1	20	0	1.00e+00	Retreg2
Time in novel zone, hab. session 2	3159.43	2	1	20	0	1.00e+00	Atg4c Retreg2
Total zone transitions, hab. session 2	35.66	2	1	20	0	1.00e+00	Ndufb9 Retreg2
Total locomotion distance, hab. session 2	22.17	1	1	20	0	1.00e+00	Retreg2
Locomotion velocity, hab. session 2	31.27	1	1	20	0	1.00e+00	Retreg2
Novel to familiar place preference ratio	7674.27	2	1	20	0	1.00e+00	Atg4c Retreg2
Novelty place preference	7469.82	2	1	20	0	1.00e+00	Atg4c Retreg2
Time in novel zone, NPP test	5350.38	2	1	20	0	1.00e+00	Atg4c Retreg2
Total zone transitions, NPP test	980.79	2	2	40	0	1.00e+00	Ndufb9 Retreg2
Total locomotion distance, NPP test	1687.31	1	1	20	0	1.00e+00	Retreg2
Locomotion velocity, NPP test	953.07	1	1	20	0	1.00e+00	Retreg2
Pavlov. Cond. lever latency	168.22	3	1	20	0	1.00e+00	Atg4c Ndufb9 Retreg2
Pavlov. Cond. change in total contacts	1037.76	1	1	20	0	1.00e+00	Retreg2
Pavlov. Cond. index score	195.36	2	1	20	0	1.00e+00	Atg4c Retreg2
Pavlov. Cond. latency score	404.63	1	1	20	0	1.00e+00	Retreg2
Pavlov. Cond. lever contacts	232.62	3	1	20	0	1.00e+00	Atg4c Ndufb9 Retreg2
Pavlov. Cond. magazine entry number	491.61	1	1	20	0	1.00e+00	Retreg2
Pavlov. Cond. intertrial magazine entries	69.21	2	1	20	0	1.00e+00	Ndufb9 Retreg2
Pavlov. Cond. lever-magazine prob. diff.	212.16	2	1	20	0	1.00e+00	Atg4c Retreg2
Pavlov. Cond. response bias	296.22	2	1	20	0	1.00e+00	Atg4c Retreg2
Bone: apparent density	2735.95	2	1	20	0	1.00e+00	Ndufb9 Retreg2
Bone surface	6197.68	1	1	20	0	1.00e+00	Retreg2
Bone volume	8624.75	1	1	20	0	1.00e+00	Retreg2
Bone: connectivity density	841.82	2	1	20	0	1.00e+00	Ndufb9 Retreg2
Bone: cortical apparent density	6014.36	2	1	20	0	1.00e+00	Ndufb9 Retreg2
Bone: cortical area	2293.91	2	1	20	0	1.00e+00	Ndufb9 Retreg2
Bone: cortical porosity	221.79	2	1	20	0	1.00e+00	Ndufb9 Retreg2
Bone: cortical porosity	560.57	2	1	20	0	1.00e+00	Ndufb9 Retreg2
Bone: cortical thickness	128.8	3	1	20	0	1.00e+00	Mindy4b Ndufb9 Retreg2
Bone: cortical thickness	1464.97	2	1	20	0	1.00e+00	Ndufb9 Retreg2
Bone: cortical tissue density	6505.97	2	1	20	0	1.00e+00	Ndufb9 Retreg2
Bone: elastic displacement	7604.03	1	1	20	0	1.00e+00	Retreg2
Bone: elastic work	361.86	1	1	20	0	1.00e+00	Retreg2
Bone: endosteal estimation	2974.46	3	1	20	0	1.00e+00	Mindy4b Ndufb9 Retreg2
Bone: endosteal perimeter	11863.6	1	1	20	0	1.00e+00	Retreg2
Bone: final force	1600.36	1	1	20	0	1.00e+00	Retreg2
Bone: final moment	219.15	1	1	20	0	1.00e+00	Retreg2
Bone: marrow area	4718.77	2	1	20	0	1.00e+00	Ndufb9 Retreg2
Bone: maximum diameter	3037.24	2	1	20	0	1.00e+00	Ndufb9 Retreg2
Bone: maximum force	8697.09	1	1	20	0	1.00e+00	Retreg2
Bone: maximum moment	2996.54	2	1	20	0	1.00e+00	Ndufb9 Retreg2
Bone: minimum diameter	4100.86	1	1	20	0	1.00e+00	Retreg2
Bone: periosteal estimation	9791.57	1	1	20	0	1.00e+00	Retreg2
Bone: periosteal perimeter	11400.25	1	1	20	0	1.00e+00	Retreg2
Bone: post-yield work	6839.22	2	1	20	0	1.00e+00	Mindy4b Retreg2
Bone: stiffness	9032.86	1	1	20	0	1.00e+00	Retreg2
Bone: tissue strength	2995.95	1	1	20	0	1.00e+00	Retreg2
Bone: trabecular number	5387.39	2	2	40	0	1.00e+00	Ndufb9 Retreg2
Bone: trabecular spacing	3988.39	2	2	40	0	1.00e+00	Ndufb9 Retreg2
Bone: trabecular thickness	8476.26	1	1	20	0	1.00e+00	Retreg2
Bone: trabecular tissue density	7288.68	2	2	40	0	1.00e+00	Ndufb9 Retreg2
Breakpoint value in progressive ratio session	37605.61	1	1	20	0	1.00e+00	Retreg2
Distance traveled before self-admin	12646.75	4	2	40	-1	7.63e-04	Atg4c Ndufb9 Retreg2 Zfp575
Distance traveled after self-admin	10842.81	3	2	40	0	1.00e+00	Atg4c Retreg2 Zfp575
Delta time in closed arm before/after self-admin	91.45	3	1	20	0	1.00e+00	Atg4c Ndufb9 Retreg2
Delta time in open arm before/after self-admin	7574.84	2	1	20	0	1.00e+00	Atg4c Retreg2
Diff in mean of infusions in LGA sessions	12228.39	3	2	40	0	1.00e+00	Atg4c Ndufb9 Retreg2
Extinction: sum of active levers before priming	9473.6	3	2	40	0	1.00e+00	Mindy4b Ndufb9 Retreg2
Active lever presses in extinction session 6	738.98	1	1	20	0	1.00e+00	Retreg2
Delta distance traveled before/after self-admin	1485.64	2	2	40	0	1.00e+00	Ndufb9 Retreg2
Delta ambulatory time before/after self-admin	10289.08	3	1	20	0	1.00e+00	Atg4c Ndufb9 Retreg2
Time in closed arm before self-admin	13438.3	2	1	20	0	1.00e+00	Atg4c Retreg2
Time in closed arm after self-admin	4591.18	1	1	20	0	1.00e+00	Retreg2
Time in open arm before self-admin	1772.52	5	2	40	1	1.85e-05	Atg4c Mindy4b Ndufb9 Retreg2 Zfp575
Time in open arm after self-admin	261.21	2	2	40	0	1.00e+00	Ndufb9 Retreg2
Sum of active levers in priming session hrs 5-6	496.26	2	1	20	0	1.00e+00	Ndufb9 Retreg2
Time to tail flick, vehicle, before self-admin	4460.73	3	1	20	0	1.00e+00	Mindy4b Ndufb9 Retreg2
Time to tail flick, vehicle, after self-admin	10545.29	4	1	20	-1	5.85e-04	Mindy4b Ndufb9 Retreg2 Zfp575
Time to tail flick, test, before self-admin	2051.23	4	2	40	0.99	5.18e-03	Atg4c Ndufb9 Retreg2 Zfp575
Time to tail flick, test, after self-admin	504.65	3	3	60	0	1.00e+00	Mindy4b Ndufb9 Retreg2
Delta time to tail flick, vehicle, before/after SA	4908.61	2	1	20	0	1.00e+00	Mindy4b Retreg2
Delta time to tail flick, test, before/after SA	5241.49	3	2	40	0	1.00e+00	Mindy4b Ndufb9 Retreg2
Ambulatory time before self-admin	39448.07	2	2	40	0	1.00e+00	Atg4c Retreg2
Ambulatory time after self-admin	13342.05	2	2	40	0	1.00e+00	Atg4c Retreg2
Total heroin consumption	128.55	2	1	20	0	1.00e+00	Atg4c Retreg2
Area under the delay curve	8275.39	3	2	40	0	1.00e+00	Atg4c Mindy4b Retreg2
Delay disc. indifference point, 0s delay	1084.93	2	1	20	0	1.00e+00	Mindy4b Retreg2
Delay disc. indifference point, 16s delay	7333.77	3	2	40	0	1.00e+00	Atg4c Mindy4b Retreg2
Delay disc. indifference point, 2s delay	60.41	3	1	20	0	1.00e+00	Atg4c Mindy4b Retreg2
Delay disc. indifference point, 24s delay	16221.71	2	1	20	0	1.00e+00	Atg4c Retreg2
Delay disc. indifference point, 4s delay	170.26	4	2	40	0.94	5.75e-02	Atg4c Mindy4b Ndufb9 Retreg2
Delay disc. indifference point, 8s delay	16687.82	2	1	20	0	1.00e+00	Atg4c Retreg2
Delay discount exponential model param	5653.27	3	2	40	0	1.00e+00	Atg4c Mindy4b Retreg2
Delay discount hyperbolic model param	4106.2	3	2	40	0	1.00e+00	Atg4c Mindy4b Retreg2
Fecal boli incidents, locomotor time 1	30605	2	1	20	0	1.00e+00	Atg4c Retreg2
Change in fecal boli incidents, locomotor task	1904.41	3	2	40	0	1.00e+00	Mindy4b Ndufb9 Retreg2
Time >=10cm from walls, locomotor time 1	3262.42	4	1	20	0.99	5.31e-03	Atg4c Mindy4b Ndufb9 Retreg2
Bouts of movement, locomotor time 1	5395.51	2	1	20	0	1.00e+00	Ndufb9 Retreg2
Total resting periods, locomotor time 1	2793.59	1	1	20	0	1.00e+00	Retreg2
Rest time, locomotor task time 1	11183.83	2	1	20	0	1.00e+00	Ndufb9 Retreg2
Distance moved, locomotor task time 1	34443.92	2	2	40	0	1.00e+00	Ndufb9 Retreg2
Vertical activity count, locomotor time 1	71180.23	2	1	20	0	1.00e+00	Retreg2 Zfp575
Time >=10cm from walls, locomotor time 2	35595.55	2	2	40	0	1.00e+00	Mindy4b Retreg2
Bouts of movement, locomotor time 2	41021.38	2	1	20	0	1.00e+00	Mindy4b Retreg2
Total resting periods, locomotor time 2	49524.91	2	1	20	0	1.00e+00	Mindy4b Retreg2
Rest time, locomotor task time 2	8506.21	3	1	20	0	1.00e+00	Atg4c Ndufb9 Retreg2
Distance moved, locomotor task time 2	2834.01	3	1	20	0	1.00e+00	Atg4c Mindy4b Retreg2
Vertical activity count, locomotor time 2	17863.79	3	2	40	0	1.00e+00	Atg4c Mindy4b Retreg2
Weight adjusted by age	23614.28	3	2	40	0	1.00e+00	Ndufb9 Retreg2 Zfp575
Seeking ratio, delayed vs. immediate footshock	4491.19	3	1	20	0	1.00e+00	Mindy4b Retreg2 Zfp575
Locomotion in novel chamber	1993.33	2	2	40	0	1.00e+00	Ndufb9 Retreg2
Locomotion in novel chamber post-restriction	21811.96	3	1	20	0	1.00e+00	Mindy4b Ndufb9 Retreg2
Progressive ratio	22646.19	3	2	40	0	1.00e+00	Mindy4b Ndufb9 Retreg2
Food seeking constrained by brief footshock	475.92	4	1	20	1	1.23e-03	Atg4c Ndufb9 Retreg2 Zfp575
Seeking ratio, punishment vs. effort	20653.58	2	2	40	0	1.00e+00	Ndufb9 Retreg2
Run reversals in cocaine runway, females	9406.04	1	1	20	0	1.00e+00	Retreg2
Run reversals in cocaine runway, males	3884.61	2	2	40	0	1.00e+00	Ndufb9 Retreg2
Latency to leave start box in cocaine runway	16290.75	1	1	20	0	1.00e+00	Retreg2
Latency to leave start box in cocaine runway, F	2400.69	3	2	40	0	1.00e+00	Mindy4b Ndufb9 Retreg2
Latency to leave start box in cocaine runway, M	582.13	3	1	20	0	1.00e+00	Ndufb9 Retreg2 Zfp575
Co content in liver	1133.25	1	1	20	0	1.00e+00	Retreg2
Cu content in liver	28.08	2	1	20	0	1.00e+00	Ndufb9 Retreg2
Fe content in liver	1344.53	1	1	20	0	1.00e+00	Retreg2
K content in liver	1519.62	1	1	20	0	1.00e+00	Retreg2
Mg content in liver	6026.97	1	1	20	0	1.00e+00	Retreg2
Mn content in liver	537.3	2	2	40	0	1.00e+00	Ndufb9 Retreg2
Na content in liver	2013.84	2	1	20	0	1.00e+00	Ndufb9 Retreg2
Rb content in liver	71.08	2	2	40	0	1.00e+00	Ndufb9 Retreg2
Se content in liver	8.63	1	0	0	0	1.00e+00	Ndufb9
Zn content in liver	1887.46	2	2	40	0	1.00e+00	Ndufb9 Retreg2

Associations by panel

Tissue	RNA modality	# hits	% hits/tests	Avg chisq
Adipose	alternative polyA	0	0	1.03
Adipose	alternative TSS	0	0	0.97
Adipose	gene expression	0	0	1
Adipose	isoform ratio	0	0	0.99
Adipose	intron excision ratio	0	0	0.99
Adipose	mRNA stability	1	0	1.03
BLA	alternative polyA	0	0	1.1
BLA	alternative TSS	0	0	1.03
BLA	gene expression	0	0	1.04
BLA	isoform ratio	0	0	1.02
BLA	intron excision ratio	0	0	0.97
BLA	mRNA stability	0	0	1.01
Brain	alternative polyA	0	0	1.07
Brain	alternative TSS	0	0	1.04
Brain	gene expression	0	0	1.03
Brain	isoform ratio	0	0	1.05
Brain	intron excision ratio	0	0	0.99
Brain	mRNA stability	0	0	1.04
Eye	alternative polyA	0	0	0.94
Eye	alternative TSS	0	0	1.17
Eye	gene expression	0	0	1.09
Eye	isoform ratio	0	0	1.06
Eye	intron excision ratio	0	0	1.05
Eye	mRNA stability	0	0	1.08
IC	alternative polyA	0	0	1.06
IC	alternative TSS	0	0	1.11
IC	gene expression	0	0	1.04
IC	isoform ratio	0	0	1.03
IC	intron excision ratio	1	0	0.96
IC	mRNA stability	0	0	1.04
IL	alternative polyA	0	0	1.12
IL	alternative TSS	0	0	1.08
IL	gene expression	0	0	1
IL	isoform ratio	0	0	1.03
IL	intron excision ratio	0	0	0.91
IL	mRNA stability	0	0	1.07
LHb	alternative polyA	0	0	1.15
LHb	alternative TSS	0	0	1.1
LHb	gene expression	0	0	1
LHb	isoform ratio	0	0	1.05
LHb	intron excision ratio	0	0	0.88
LHb	mRNA stability	0	0	1.03
Liver	alternative polyA	0	0	1.05
Liver	alternative TSS	0	0	1
Liver	gene expression	0	0	1.02
Liver	isoform ratio	0	0	1.05
Liver	intron excision ratio	0	0	0.99
Liver	mRNA stability	0	0	1.02
NAcc	alternative polyA	1	0	21.51
NAcc	alternative TSS	0	0	1.03
NAcc	gene expression	0	0	1.02
NAcc	isoform ratio	0	0	1.01
NAcc	intron excision ratio	1	0	0.99
NAcc	mRNA stability	0	0	1.06
OFC	alternative polyA	0	0	1.08
OFC	alternative TSS	0	0	1.06
OFC	gene expression	0	0	1.01
OFC	isoform ratio	0	0	1.04
OFC	intron excision ratio	0	0	0.81
OFC	mRNA stability	0	0	1.09
PL	alternative polyA	0	0	1.1
PL	alternative TSS	0	0	1.02
PL	gene expression	0	0	1.01
PL	isoform ratio	0	0	1.01
PL	intron excision ratio	0	0	0.99
PL	mRNA stability	1	0	1.05
pVTA	alternative polyA	0	0	1.08
pVTA	alternative TSS	0	0	1.05
pVTA	gene expression	0	0	1.03
pVTA	isoform ratio	0	0	1.04
pVTA	intron excision ratio	0	0	0.96
pVTA	mRNA stability	0	0	1.09
RMTg	alternative polyA	0	0	0.95
RMTg	alternative TSS	0	0	1.16
RMTg	gene expression	0	0	1
RMTg	isoform ratio	0	0	1.03
RMTg	intron excision ratio	0	0	0.93
RMTg	mRNA stability	0	0	1.13