Active lever presses in extinction session 6

Number of active lever presses of Extinction session 6

Tags: Behavior · Heroin

Project: u01_peter_kalivas

1 locus · 1 gene with independent associations · 1 total associated gene

Significant Loci

# Chr Start pos End pos # assoc genes # joint models Best TWAS P Best GWAS P Cond GWAS P Joint genes
1 chr4 95890735 97085238 1 1 1.09e-07 1.42e-01 1.37e-15 Serbp1

Pleiotropic Associations

Trait Chi2 ratio # genes+ # genes++ % genes++ Corr Corr P Genes
BMI without tail 5.19 1 0 0 0 1e+00 Serbp1
Body weight 1.05 1 0 0 0 1e+00 Serbp1
Right kidney weight 8.78 1 0 0 0 1e+00 Serbp1
Tail length 2.86 1 0 0 0 1e+00 Serbp1
Length with tail 3.13 1 0 0 0 1e+00 Serbp1
Liver weight, left 7.79 1 0 0 0 1e+00 Serbp1
Retroperitoneal fat weight 3.15 1 0 0 0 1e+00 Serbp1
Intraocular pressure 5.48 1 0 0 0 1e+00 Serbp1
Patch foraging indifference point AUC 12.17 1 0 0 0 1e+00 Serbp1
Patch foraging total patch changes 18 sec 10.94 1 0 0 0 1e+00 Serbp1
Patch foraging total patch changes 6 sec 7.52 1 0 0 0 1e+00 Serbp1
Patch foraging water rate 0 sec 6.51 1 0 0 0 1e+00 Serbp1
Patch foraging water rate 12 sec 4.1 1 0 0 0 1e+00 Serbp1
Patch foraging water rate 18 sec 5.55 1 0 0 0 1e+00 Serbp1
Locomotor activity 3.36 1 0 0 0 1e+00 Serbp1
Light reinforcement 1 8.51 1 0 0 0 1e+00 Serbp1
Light reinforcement 2 7.05 1 0 0 0 1e+00 Serbp1
Reaction time mean AUC 4.32 1 0 0 0 1e+00 Serbp1
Median of all reaction times 2.95 1 0 0 0 1e+00 Serbp1
Reaction time omissions 4.8 1 0 0 0 1e+00 Serbp1
Reaction time premature initiation rate 3.29 1 0 0 0 1e+00 Serbp1
Reaction time premature initiations 6.63 1 0 0 0 1e+00 Serbp1
Reaction time trials AUC 3.16 1 0 0 0 1e+00 Serbp1
Social time 4.57 1 0 0 0 1e+00 Serbp1
Conditioned locomotion 8.52 1 0 0 0 1e+00 Serbp1
Intermitt. access day 15 inactive lever presses 5.48 1 0 0 0 1e+00 Serbp1
Intermittent access day 1 total infusions 11.42 1 0 0 0 1e+00 Serbp1
Intermittent access day 15 total infusions 11.11 1 0 0 0 1e+00 Serbp1
Intermittent access terminal intake (last 3 days) 36.38 1 1 100 0 1e+00 Serbp1
Intermittent access total infusions 9.95 1 0 0 0 1e+00 Serbp1
Intermittent access standard deviation 5.46 1 0 0 0 1e+00 Serbp1
Cocaine induced anxiety 3.68 1 0 0 0 1e+00 Serbp1
Lifetime Intake 10.49 1 0 0 0 1e+00 Serbp1
Progressive ratio test 1 active lever presses 22.83 1 0 0 0 1e+00 Serbp1
Progressive ratio test 1 breakpoint 29.2 1 1 100 0 1e+00 Serbp1
Progressive ratio test 1 inactive lever presses 11.37 1 0 0 0 1e+00 Serbp1
Progressive ratio test 2 active lever presses 10.25 1 0 0 0 1e+00 Serbp1
Progressive ratio test 2 breakpoint 10.07 1 0 0 0 1e+00 Serbp1
Progressive ratio test 2 inactive lever presses 6.75 1 0 0 0 1e+00 Serbp1
Total sessions with >9 infusions 40.15 1 1 100 0 1e+00 Serbp1
Short access day 1 total inactive lever presses 51.32 1 1 100 0 1e+00 Serbp1
Short access day 10 total inactive lever presses 35.25 1 1 100 0 1e+00 Serbp1
Short access day 1 total infusions 18.8 1 0 0 0 1e+00 Serbp1
Short access total infusions 9.9 1 0 0 0 1e+00 Serbp1
Short access day 1 locomotion 8.45 1 0 0 0 1e+00 Serbp1
Compulsive drug intake 12.43 1 0 0 0 1e+00 Serbp1
Number of responses in last shaping day 7.09 1 0 0 0 1e+00 Serbp1
Locomotion velocity, session 7 6.12 1 0 0 0 1e+00 Serbp1
Delta time in closed arm before/after self-admin 10.9 1 0 0 0 1e+00 Serbp1
Delta time in open arm before/after self-admin 23.57 1 0 0 0 1e+00 Serbp1
Diff in mean of infusions in LGA sessions 18.85 1 0 0 0 1e+00 Serbp1
Delta ambulatory time before/after self-admin 4.21 1 0 0 0 1e+00 Serbp1
Time in closed arm before self-admin 13.02 1 0 0 0 1e+00 Serbp1
Time in closed arm after self-admin 7.53 1 0 0 0 1e+00 Serbp1
Time in open arm after self-admin 3.6 1 0 0 0 1e+00 Serbp1
Sum of active levers in priming session hrs 5-6 8.73 1 0 0 0 1e+00 Serbp1
Time to tail flick, vehicle, before self-admin 14.83 1 0 0 0 1e+00 Serbp1
Time to tail flick, vehicle, after self-admin 50.98 1 1 100 0 1e+00 Serbp1
Time to tail flick, test, before self-admin 5.82 1 0 0 0 1e+00 Serbp1
Delta time to tail flick, vehicle, before/after SA 9.85 1 0 0 0 1e+00 Serbp1
Ambulatory time after self-admin 17.94 1 0 0 0 1e+00 Serbp1
Total heroin consumption 10.71 1 0 0 0 1e+00 Serbp1
Change in fecal boli incidents, locomotor task 13.85 1 0 0 0 1e+00 Serbp1
Rest time, locomotor task time 1 16.73 1 0 0 0 1e+00 Serbp1
Vertical activity count, locomotor time 1 12.05 1 0 0 0 1e+00 Serbp1
Time >=10cm from walls, locomotor time 2 4.27 1 0 0 0 1e+00 Serbp1
Vertical activity count, locomotor time 2 6.77 1 0 0 0 1e+00 Serbp1
Seeking ratio, delayed vs. immediate footshock 5.96 1 0 0 0 1e+00 Serbp1
Locomotion in novel chamber post-restriction 18.24 1 0 0 0 1e+00 Serbp1

Associations by panel

Tissue RNA modality # hits % hits/tests Avg chisq
Adipose alternative polyA 0 0 1.01
Adipose alternative TSS 0 0 0.99
Adipose gene expression 0 0 0.94
Adipose isoform ratio 0 0 0.99
Adipose intron excision ratio 0 0 0.98
Adipose mRNA stability 0 0 0.97
BLA alternative polyA 0 0 1.04
BLA alternative TSS 0 0 1.04
BLA gene expression 0 0 0.97
BLA isoform ratio 0 0 1.01
BLA intron excision ratio 0 0 0.95
BLA mRNA stability 0 0 0.95
Brain alternative polyA 0 0 0.98
Brain alternative TSS 0 0 0.99
Brain gene expression 0 0 0.95
Brain isoform ratio 0 0 0.96
Brain intron excision ratio 0 0 0.97
Brain mRNA stability 0 0 0.94
Eye alternative polyA 0 0 1.06
Eye alternative TSS 0 0 1.02
Eye gene expression 0 0 0.91
Eye isoform ratio 0 0 1.06
Eye intron excision ratio 0 0 0.94
Eye mRNA stability 0 0 0.91
IL alternative polyA 0 0 1.13
IL alternative TSS 0 0 1.01
IL gene expression 0 0 0.93
IL isoform ratio 0 0 1.01
IL intron excision ratio 0 0 0.94
IL mRNA stability 0 0 0.94
LHb alternative polyA 0 0 1.08
LHb alternative TSS 0 0 1.08
LHb gene expression 0 0 0.95
LHb isoform ratio 0 0 1.05
LHb intron excision ratio 0 0 0.91
LHb mRNA stability 0 0 0.95
Liver alternative polyA 0 0 0.91
Liver alternative TSS 0 0 0.94
Liver gene expression 0 0 0.96
Liver isoform ratio 1 0 1
Liver intron excision ratio 0 0 0.91
Liver mRNA stability 0 0 0.97
NAcc alternative polyA 0 0 1.03
NAcc alternative TSS 0 0 0.97
NAcc gene expression 0 0 0.98
NAcc isoform ratio 0 0 1.01
NAcc intron excision ratio 0 0 0.96
NAcc mRNA stability 0 0 0.96
OFC alternative polyA 0 0 1.07
OFC alternative TSS 0 0 0.98
OFC gene expression 0 0 0.98
OFC isoform ratio 0 0 1.05
OFC intron excision ratio 0 0 0.88
OFC mRNA stability 0 0 0.98
PL alternative polyA 0 0 1.05
PL alternative TSS 0 0 0.98
PL gene expression 0 0 0.96
PL isoform ratio 0 0 0.99
PL intron excision ratio 0 0 0.98
PL mRNA stability 0 0 0.99
pVTA alternative polyA 0 0 1.03
pVTA alternative TSS 0 0 1.03
pVTA gene expression 0 0 0.96
pVTA isoform ratio 0 0 0.99
pVTA intron excision ratio 0 0 0.99
pVTA mRNA stability 0 0 0.93
RMTg alternative polyA 0 0 0.93
RMTg alternative TSS 0 0 0.82
RMTg gene expression 0 0 0.93
RMTg isoform ratio 0 0 0.95
RMTg intron excision ratio 0 0 0.97
RMTg mRNA stability 0 0 0.92