Hub : Traits

Delta time to tail flick, vehicle, before/after SA

Delta time in sec to remove tail from noxious stimuli under vehicle conditions in the first tail flick before self admin vs after self admin

Tags: Behavior · Heroin

Project: u01_peter_kalivas

3 loci · 3 genes with independent associations · 3 total associated genes

Significant Loci

#	Chr	Start pos	End pos	# assoc genes	# joint models	Best TWAS P	Best GWAS P	Cond GWAS P	Joint genes
1	chr4	10085840	10964652	1	1	2.31e-09	2.35e-02	4.4e-06	Abcb8
2	chr7	14449451	15768722	1	1	3.08e-28	3.66e-01	1.0e+00	LOC102551633
3	chr9	75969545	77365260	1	1	8.36e-18	4.64e-05	1.0e+00	Zfand2b

Pleiotropic Associations

Trait	Chi2 ratio	# genes+	# genes++	% genes++	Corr	Corr P	Genes
BMI with tail	5.52	2	1	33.3	0	1e+00	Abcb8 Zfand2b
BMI without tail	53.65	1	1	33.3	0	1e+00	Zfand2b
Epididymis fat weight	111.28	1	1	33.3	0	1e+00	Zfand2b
Heart weight	71.7	1	1	33.3	0	1e+00	Zfand2b
Left kidney weight	27.22	1	1	33.3	0	1e+00	Zfand2b
Right kidney weight	54.05	1	1	33.3	0	1e+00	Zfand2b
Tail length	125.62	1	1	33.3	0	1e+00	Zfand2b
Length with tail	4.78	1	0	0	0	1e+00	Zfand2b
Length without tail	77.43	1	1	33.3	0	1e+00	Zfand2b
Liver weight, right	17.57	1	1	33.3	0	1e+00	Zfand2b
Parametrial fat weight	9.99	1	0	0	0	1e+00	Zfand2b
Retroperitoneal fat weight	7.53	1	0	0	0	1e+00	Zfand2b
Intraocular pressure	51.69	1	1	33.3	0	1e+00	Zfand2b
Number of licking bursts	32.5	1	1	33.3	0	1e+00	Zfand2b
Food consumed during 24 hour testing period	15.78	1	0	0	0	1e+00	Zfand2b
Times rat made contact with spout	9.25	1	0	0	0	1e+00	Zfand2b
Mean time between licks in bursts	9.22	1	0	0	0	1e+00	Zfand2b
Mean num. licks in bursts	18.13	1	0	0	0	1e+00	Zfand2b
Std. dev. time between licks in bursts	12.12	1	0	0	0	1e+00	Zfand2b
Water consumed over 24 hours	34.33	1	1	33.3	0	1e+00	Zfand2b
Patch foraging indifference point 0 sec	8.61	3	0	0	0	1e+00	Abcb8 LOC102551633 Zfand2b
Patch foraging indifference point AUC	24.2	1	1	33.3	0	1e+00	Zfand2b
Indifference point function ln k	54.42	1	1	33.3	0	1e+00	Zfand2b
Indifference point function log k	54.42	1	1	33.3	0	1e+00	Zfand2b
Patch foraging total patch changes 0 sec	12.25	3	1	33.3	0	1e+00	Abcb8 LOC102551633 Zfand2b
Patch foraging total patch changes 18 sec	48.28	1	1	33.3	0	1e+00	Zfand2b
Patch foraging total patch changes 24 sec	77.61	1	1	33.3	0	1e+00	Zfand2b
Patch foraging total patch changes 6 sec	11.84	3	1	33.3	0	1e+00	Abcb8 LOC102551633 Zfand2b
Patch foraging time to switch 0 sec	33.47	1	1	33.3	0	1e+00	Zfand2b
Patch foraging water rate 0 sec	39.47	1	1	33.3	0	1e+00	Zfand2b
Patch foraging water rate 12 sec	38.65	2	1	33.3	0	1e+00	Abcb8 Zfand2b
Patch foraging water rate 18 sec	9.71	1	0	0	0	1e+00	Zfand2b
Patch foraging water rate 24 sec	12.61	1	0	0	0	1e+00	Zfand2b
Patch foraging water rate 6 sec	35.43	1	1	33.3	0	1e+00	Zfand2b
Locomotor activity	8.29	2	0	0	0	1e+00	LOC102551633 Zfand2b
Locomotor testing distance	25.56	2	1	33.3	0	1e+00	LOC102551633 Zfand2b
Locomotor testing rearing	99.51	1	1	33.3	0	1e+00	Zfand2b
Light reinforcement 1	19.25	1	1	33.3	0	1e+00	Zfand2b
Light reinforcement 2	6.57	1	0	0	0	1e+00	Zfand2b
Reaction time number correct	114.79	1	1	33.3	0	1e+00	Zfand2b
Reaction time mean minus median	179.03	1	1	33.3	0	1e+00	Zfand2b
Reaction time mean minus median AUC	232.47	1	1	33.3	0	1e+00	Zfand2b
Reaction time num false alarms	5.03	2	0	0	0	1e+00	Abcb8 Zfand2b
Reaction time num false alarms AUC	27.43	1	1	33.3	0	1e+00	Zfand2b
Reaction time trials correct on left	114.79	1	1	33.3	0	1e+00	Zfand2b
Reaction time trials on left	106.69	1	1	33.3	0	1e+00	Zfand2b
Reaction time mean	36.11	1	1	33.3	0	1e+00	Zfand2b
Reaction time mean AUC	33.75	1	1	33.3	0	1e+00	Zfand2b
Median of all reaction times	17.65	1	0	0	0	1e+00	Zfand2b
Reaction time omissions	29.95	2	1	33.3	0	1e+00	Abcb8 Zfand2b
Reaction time premature initiations	23.67	2	1	33.3	0	1e+00	Abcb8 Zfand2b
Std. dev. reaction times	72.92	1	1	33.3	0	1e+00	Zfand2b
Reaction time trials completed	106.69	1	1	33.3	0	1e+00	Zfand2b
Reaction time trials AUC	108.76	1	1	33.3	0	1e+00	Zfand2b
Social response proportion	6.01	1	0	0	0	1e+00	Zfand2b
Cocaine response after cond. corrected	12.71	1	0	0	0	1e+00	Zfand2b
Cocaine response after cond. not corrected	10.73	1	0	0	0	1e+00	Zfand2b
Saline control response	8.43	1	0	0	0	1e+00	Zfand2b
Condit. Reinf. lever presses	5.55	1	0	0	0	1e+00	Zfand2b
Conditioned reinforcement - actives	56.53	3	1	33.3	0	1e+00	Abcb8 LOC102551633 Zfand2b
Conditioned reinforcement - inactives	70.68	2	1	33.3	0	1e+00	LOC102551633 Zfand2b
Conditioned locomotion	33.79	2	1	33.3	0	1e+00	LOC102551633 Zfand2b
Intermittent access intake day 1-15 change	156.77	1	1	33.3	0	1e+00	Zfand2b
Intermittent access intake escalation	117.41	1	1	33.3	0	1e+00	Zfand2b
Intermittent access intake escalation 2	17.19	2	0	0	0	1e+00	Abcb8 LOC102551633
Intermitt. access day 1 inactive lever presses	169.63	1	1	33.3	0	1e+00	Zfand2b
Intermitt. access day 15 inactive lever presses	294.26	1	1	33.3	0	1e+00	Zfand2b
Intermitt. access escalation Index	57.91	1	1	33.3	0	1e+00	LOC102551633
Intermittent access day 1 total infusions	45.46	2	1	33.3	0	1e+00	LOC102551633 Zfand2b
Intermittent access day 15 total infusions	20.83	2	1	33.3	0	1e+00	LOC102551633 Zfand2b
Intermittent access terminal intake (last 3 days)	42.12	2	2	66.7	0	1e+00	LOC102551633 Zfand2b
Intermittent access total infusions	12.85	1	0	0	0	1e+00	LOC102551633
Intermittent access day 1 locomotion	26.47	1	1	33.3	0	1e+00	Zfand2b
Intermittent access day 15 total locomotion	62.98	2	2	66.7	0	1e+00	LOC102551633 Zfand2b
Intermittent access total locomotion	12.69	2	0	0	0	1e+00	LOC102551633 Zfand2b
Intermittent access standard deviation	442.51	1	1	33.3	0	1e+00	Zfand2b
Cocaine induced anxiety	66.66	2	1	33.3	0	1e+00	Abcb8 Zfand2b
Baseline Anxiety	202.79	2	1	33.3	0	1e+00	Abcb8 Zfand2b
Lifetime Intake	15.71	1	0	0	0	1e+00	LOC102551633
Incentive Sensitization - Responses	110.07	3	1	33.3	0	1e+00	Abcb8 LOC102551633 Zfand2b
Incentive Sensitization - Breakpoint	106.36	3	1	33.3	0	1e+00	Abcb8 LOC102551633 Zfand2b
Progressive ratio test 1 active lever presses	21.63	2	1	33.3	0	1e+00	LOC102551633 Zfand2b
Progressive ratio test 1 breakpoint	27.96	2	1	33.3	0	1e+00	LOC102551633 Zfand2b
Progressive ratio test 1 inactive lever presses	30.05	1	1	33.3	0	1e+00	LOC102551633
Progressive ratio test 2 active lever presses	109.22	1	1	33.3	0	1e+00	Zfand2b
Progressive ratio test 2 breakpoint	106.65	1	1	33.3	0	1e+00	Zfand2b
Progressive ratio test 2 inactive lever presses	42.89	2	1	33.3	0	1e+00	LOC102551633 Zfand2b
Short access day 1 total inactive lever presses	17.58	3	0	0	0	1e+00	Abcb8 LOC102551633 Zfand2b
Short access day 10 total inactive lever presses	30.09	2	1	33.3	0	1e+00	LOC102551633 Zfand2b
Short access day 1 total infusions	71.59	1	1	33.3	0	1e+00	LOC102551633
Short access day 10 total infusions	19.58	2	1	33.3	0	1e+00	Abcb8 LOC102551633
Short access total infusions	43.84	1	1	33.3	0	1e+00	LOC102551633
Short access day 1 locomotion	55.44	3	1	33.3	0	1e+00	Abcb8 LOC102551633 Zfand2b
Short access day 10 total locomotion	219.35	2	1	33.3	0	1e+00	Abcb8 Zfand2b
Short access total locomotion	209.96	1	1	33.3	0	1e+00	Zfand2b
Compulsive drug intake	41.27	2	1	33.3	0	1e+00	Abcb8 Zfand2b
One hour access (0.3 mA shock)	22.58	1	0	0	0	1e+00	Zfand2b
One hour access (shock baseline)	6.09	1	0	0	0	1e+00	LOC102551633
Number of responses in last shaping day	32.11	3	1	33.3	0	1e+00	Abcb8 LOC102551633 Zfand2b
Locomotion distance, session 2	4.45	1	0	0	0	1e+00	Zfand2b
Degree of sensitization distance	11.08	1	0	0	0	1e+00	LOC102551633
Condit. Reinf. active minus inactive responses	16.72	1	0	0	0	1e+00	Abcb8
Condit. Reinf. active-inactive response ratio	8.58	1	0	0	0	1e+00	Abcb8
Condit. Reinf. active responses	16.06	1	0	0	0	1e+00	Abcb8
Incentive salience index mean	13.29	1	0	0	0	1e+00	Abcb8
Condit. Reinf. lever presses	4.61	1	0	0	0	1e+00	Abcb8
Time in novel zone, hab. session 1	8.85	1	0	0	0	1e+00	Abcb8
Pavlov. Cond. lever latency	5.45	1	0	0	0	1e+00	LOC102551633
Pavlov. Cond. latency score	4.54	1	0	0	0	1e+00	LOC102551633
Pavlov. Cond. lever contacts	5.74	1	0	0	0	1e+00	LOC102551633
Pavlov. Cond. intertrial magazine entries	5.02	1	0	0	0	1e+00	Abcb8
Bone: apparent density	4.12	1	0	0	0	1e+00	Abcb8
Bone volume	3.86	1	0	0	0	1e+00	Abcb8
Bone: cortical area	6.9	1	0	0	0	1e+00	Abcb8
Bone: cortical thickness	4.69	1	0	0	0	1e+00	Abcb8
Bone: elastic displacement	5.56	1	0	0	0	1e+00	Zfand2b
Bone: final force	3.95	1	0	0	0	1e+00	LOC102551633
Bone: final moment	3.68	1	0	0	0	1e+00	LOC102551633
Bone: maximum diameter	3.67	1	0	0	0	1e+00	Abcb8
Bone: maximum force	3.84	1	0	0	0	1e+00	LOC102551633
Bone: maximum moment	3.51	1	0	0	0	1e+00	LOC102551633
Bone: periosteal perimeter	3.51	1	0	0	0	1e+00	Abcb8
Bone: stiffness	4.72	1	0	0	0	1e+00	LOC102551633
Bone: trabecular number	6.09	1	0	0	0	1e+00	Abcb8
Bone: trabecular thickness	5.88	1	0	0	0	1e+00	Abcb8
Distance traveled before self-admin	23.9	3	1	33.3	0	1e+00	Abcb8 LOC102551633 Zfand2b
Distance traveled after self-admin	22.32	3	1	33.3	0	1e+00	Abcb8 LOC102551633 Zfand2b
Delta time in open arm before/after self-admin	18.23	2	0	0	0	1e+00	Abcb8 Zfand2b
Extinction: sum of active levers before priming	41.4	2	1	33.3	0	1e+00	Abcb8 LOC102551633
Active lever presses in extinction session 6	16.43	2	0	0	0	1e+00	Abcb8 Zfand2b
Delta distance traveled before/after self-admin	6.32	1	0	0	0	1e+00	Abcb8
Delta ambulatory time before/after self-admin	9.7	2	0	0	0	1e+00	LOC102551633 Zfand2b
Time in closed arm before self-admin	28.53	2	1	33.3	0	1e+00	Abcb8 Zfand2b
Time in closed arm after self-admin	21.04	2	1	33.3	0	1e+00	Abcb8 LOC102551633
Time in open arm before self-admin	26.71	2	1	33.3	0	1e+00	LOC102551633 Zfand2b
Time in open arm after self-admin	15.28	2	1	33.3	0	1e+00	Abcb8 LOC102551633
Sum of active levers in priming session hrs 5-6	20.42	3	1	33.3	0	1e+00	Abcb8 LOC102551633 Zfand2b
Time to tail flick, vehicle, before self-admin	34.81	2	1	33.3	0	1e+00	Abcb8 LOC102551633
Time to tail flick, vehicle, after self-admin	45.42	3	2	66.7	0	1e+00	Abcb8 LOC102551633 Zfand2b
Time to tail flick, test, before self-admin	10.68	1	0	0	0	1e+00	Zfand2b
Time to tail flick, test, after self-admin	9.72	2	0	0	0	1e+00	Abcb8 Zfand2b
Delta time to tail flick, test, before/after SA	23.62	1	0	0	0	1e+00	Abcb8
Ambulatory time before self-admin	16.14	3	0	0	0	1e+00	Abcb8 LOC102551633 Zfand2b
Ambulatory time after self-admin	18.01	2	0	0	0	1e+00	Abcb8 LOC102551633
Total heroin consumption	30.8	1	1	33.3	0	1e+00	LOC102551633
Area under the delay curve	31.15	1	1	33.3	0	1e+00	Zfand2b
Delay disc. indifference point, 0s delay	5.71	1	0	0	0	1e+00	Zfand2b
Delay disc. indifference point, 16s delay	69.03	1	1	33.3	0	1e+00	Zfand2b
Delay disc. indifference point, 24s delay	27.43	1	0	0	0	1e+00	Zfand2b
Delay disc. indifference point, 4s delay	22.33	1	0	0	0	1e+00	Abcb8
Delay disc. indifference point, 8s delay	74.24	1	1	33.3	0	1e+00	Zfand2b
Delay discount exponential model param	16.14	1	0	0	0	1e+00	Zfand2b
Delay discount hyperbolic model param	15.89	1	0	0	0	1e+00	Zfand2b
Fecal boli incidents, locomotor time 1	176.47	1	1	33.3	0	1e+00	Zfand2b
Time >=10cm from walls, locomotor time 1	79.04	1	1	33.3	0	1e+00	Zfand2b
Bouts of movement, locomotor time 1	12.89	2	0	0	0	1e+00	Abcb8 Zfand2b
Total resting periods, locomotor time 1	13.99	1	0	0	0	1e+00	Abcb8
Rest time, locomotor task time 1	11.47	1	0	0	0	1e+00	Zfand2b
Vertical activity count, locomotor time 1	52.28	2	1	33.3	0	1e+00	Abcb8 Zfand2b
Bouts of movement, locomotor time 2	18.9	2	0	0	0	1e+00	Abcb8 Zfand2b
Total resting periods, locomotor time 2	23.63	2	1	33.3	0	1e+00	Abcb8 Zfand2b
Rest time, locomotor task time 2	44.91	1	1	33.3	0	1e+00	Zfand2b
Distance moved, locomotor task time 2	44.61	2	1	33.3	0	1e+00	Abcb8 Zfand2b
Vertical activity count, locomotor time 2	13.16	1	0	0	0	1e+00	Zfand2b
Weight adjusted by age	7.73	2	0	0	0	1e+00	Abcb8 Zfand2b
Seeking ratio, delayed vs. immediate footshock	9.04	2	0	0	0	1e+00	LOC102551633 Zfand2b
Locomotion in novel chamber	11.46	1	0	0	0	1e+00	Abcb8
Locomotion in novel chamber post-restriction	14.04	1	0	0	0	1e+00	Zfand2b
Food seeking constrained by brief footshock	17.14	2	0	0	0	1e+00	Abcb8 Zfand2b
Run reversals in cocaine runway, females	27.5	2	1	33.3	0	1e+00	Abcb8 Zfand2b
Latency to leave start box in cocaine runway	34.23	1	1	33.3	0	1e+00	Zfand2b
Latency to leave start box in cocaine runway, F	31.9	1	1	33.3	0	1e+00	Zfand2b
Co content in liver	12.69	1	0	0	0	1e+00	LOC102551633
Fe content in liver	7.51	1	0	0	0	1e+00	LOC102551633
K content in liver	11.66	1	0	0	0	1e+00	LOC102551633
Na content in liver	44.6	1	1	33.3	0	1e+00	LOC102551633
Rb content in liver	16.75	1	0	0	0	1e+00	LOC102551633
Se content in liver	12.37	1	0	0	0	1e+00	LOC102551633

Associations by panel

Tissue	RNA modality	# hits	% hits/tests	Avg chisq
Adipose	alternative polyA	0	0	0.98
Adipose	alternative TSS	0	0	1.01
Adipose	gene expression	0	0	0.98
Adipose	isoform ratio	0	0	0.99
Adipose	intron excision ratio	0	0	0.97
Adipose	mRNA stability	0	0	0.99
BLA	alternative polyA	0	0	1.03
BLA	alternative TSS	0	0	1.05
BLA	gene expression	0	0	1.02
BLA	isoform ratio	0	0	0.97
BLA	intron excision ratio	0	0	0.96
BLA	mRNA stability	0	0	1.07
Brain	alternative polyA	0	0	1
Brain	alternative TSS	0	0	0.99
Brain	gene expression	0	0	0.99
Brain	isoform ratio	0	0	0.99
Brain	intron excision ratio	0	0	0.93
Brain	mRNA stability	0	0	1.03
Eye	alternative polyA	0	0	0.77
Eye	alternative TSS	0	0	1.13
Eye	gene expression	0	0	1.01
Eye	isoform ratio	0	0	0.89
Eye	intron excision ratio	0	0	0.89
Eye	mRNA stability	0	0	0.96
IL	alternative polyA	0	0	0.99
IL	alternative TSS	0	0	1.07
IL	gene expression	0	0	0.94
IL	isoform ratio	0	0	0.98
IL	intron excision ratio	0	0	0.93
IL	mRNA stability	0	0	0.97
LHb	alternative polyA	0	0	1.05
LHb	alternative TSS	0	0	1.03
LHb	gene expression	0	0	1.01
LHb	isoform ratio	0	0	0.97
LHb	intron excision ratio	0	0	0.84
LHb	mRNA stability	0	0	0.95
Liver	alternative polyA	1	0	0.99
Liver	alternative TSS	0	0	0.99
Liver	gene expression	0	0	0.98
Liver	isoform ratio	0	0	0.95
Liver	intron excision ratio	0	0	0.95
Liver	mRNA stability	0	0	0.95
NAcc	alternative polyA	0	0	1.04
NAcc	alternative TSS	0	0	1.01
NAcc	gene expression	0	0	1.02
NAcc	isoform ratio	0	0	1
NAcc	intron excision ratio	0	0	0.98
NAcc	mRNA stability	0	0	1.03
OFC	alternative polyA	0	0	1.04
OFC	alternative TSS	0	0	0.91
OFC	gene expression	0	0	0.99
OFC	isoform ratio	0	0	1
OFC	intron excision ratio	0	0	0.84
OFC	mRNA stability	0	0	1
PL	alternative polyA	0	0	1.07
PL	alternative TSS	0	0	1
PL	gene expression	0	0	1
PL	isoform ratio	0	0	0.99
PL	intron excision ratio	1	0	0.99
PL	mRNA stability	0	0	1.04
pVTA	alternative polyA	0	0	1.01
pVTA	alternative TSS	0	0	1.01
pVTA	gene expression	0	0	1.02
pVTA	isoform ratio	0	0	1.02
pVTA	intron excision ratio	0	0	0.98
pVTA	mRNA stability	0	0	1.01
RMTg	alternative polyA	1	0.2	1.23
RMTg	alternative TSS	0	0	0.93
RMTg	gene expression	0	0	1.02
RMTg	isoform ratio	0	0	1.01
RMTg	intron excision ratio	0	0	1.01
RMTg	mRNA stability	0	0	1.02