Hub : Traits

Latency to leave start box in cocaine runway, M

Latency to leave start box in cocaine runway task, male

Tags: Behavior · Cocaine

1 significantly associated model · 1 unique gene

Significant Loci

#	chr	p0	p1	# assoc genes	# joint models	best TWAS P	best SNP P	cond SNP P	% var exp	joint genes
1	10	62271668	63667097	1	1	1.2e-09	0.36	3.3e-14	-6744	Eral1

p0: physical position of the start of the locus. p1: physical position of the end of the locus. # joint models: number of models selected by step-wise conditional analysis.

Pleiotropic Associations

Trait	chisq ratio	# genes⁺	# genes⁺⁺	% genes⁺⁺	corr P	genes
Delay disc. indifference point, 8s delay	71.9	1	1	100	1	Eral1
Delay disc. indifference point, 16s delay	63.9	1	1	100	1	Eral1
Distance traveled before self-admin	58.4	1	1	100	1	Eral1
Ambulatory time before self-admin	49.1	1	1	100	1	Eral1
Run reversals in cocaine runway, males	48.1	1	1	100	1	Eral1
Area under the delay curve	45.5	1	1	100	1	Eral1
Time >=10cm from walls, locomotor time 2	39.8	1	1	100	1	Eral1
Delta ambulatory time before/after self-admin	37.5	1	1	100	1	Eral1
Delay discount exponential model param	36.3	1	1	100	1	Eral1
Delay discount hyperbolic model param	29.7	1	1	100	1	Eral1
Short access day 1 total infusions	28.5	1	1	100	1	Eral1
Progressive ratio	27.9	1	1	100	1	Eral1
Short access total locomotion	23.8	1	0	0	1	Eral1
Short access day 1 locomotion	23.2	1	0	0	1	Eral1
Active lever presses in extinction session 6	20.2	1	0	0	1	Eral1
Intermitt. access day 15 inactive lever presses	19.8	1	0	0	1	Eral1
Times rat made contact with spout	19.6	1	0	0	1	Eral1
Short access total infusions	17.6	1	0	0	1	Eral1
Mean num. licks in bursts	16.6	1	0	0	1	Eral1
Rest time, locomotor task time 1	15.2	1	0	0	1	Eral1
Food consumed during 24 hour testing period	14.7	1	0	0	1	Eral1
Food seeking constrained by brief footshock	14.0	1	0	0	1	Eral1
Std. dev. time between licks in bursts	13.9	1	0	0	1	Eral1
Locomotion in novel chamber post-restriction	13.5	1	0	0	1	Eral1
Distance moved, locomotor task time 2	13.4	1	0	0	1	Eral1
Latency to leave start box in cocaine runway	12.6	1	0	0	1	Eral1
Time in open arm after self-admin	10.5	1	0	0	1	Eral1
Seeking ratio, punishment vs. effort	10.2	1	0	0	1	Eral1
Time to tail flick, vehicle, before self-admin	10.1	1	0	0	1	Eral1
Delay disc. indifference point, 24s delay	9.5	1	0	0	1	Eral1
Vertical activity count, locomotor time 2	8.7	1	0	0	1	Eral1
Delta distance traveled before/after self-admin	8.5	1	0	0	1	Eral1
Extinction: sum of active levers before priming	8.2	1	0	0	1	Eral1
Delta time in open arm before/after self-admin	8.0	1	0	0	1	Eral1
Distance traveled after self-admin	7.5	1	0	0	1	Eral1
Intermittent access total locomotion	7.3	1	0	0	1	Eral1
Breakpoint value in progressive ratio session	7.3	1	0	0	1	Eral1
Ambulatory time after self-admin	6.6	1	0	0	1	Eral1
Intermittent access intake escalation 2	6.5	1	0	0	1	Eral1
Delay disc. indifference point, 4s delay	6.5	1	0	0	1	Eral1
Intermitt. access day 1 inactive lever presses	5.8	1	0	0	1	Eral1
Mean time between licks in bursts	5.6	1	0	0	1	Eral1
Rest time, locomotor task time 2	5.6	1	0	0	1	Eral1
Time to tail flick, vehicle, after self-admin	4.9	1	0	0	1	Eral1
Short access day 10 total inactive lever presses	4.2	1	0	0	1	Eral1
Distance moved, locomotor task time 1	3.7	1	0	0	1	Eral1
Heart weight	3.6	1	0	0	1	Eral1
Weight adjusted by age	3.4	1	0	0	1	Eral1
Total heroin consumption	3.3	1	0	0	1	Eral1
Left kidney weight	1.5	1	0	0	1	Eral1

chisq ratio: Average Chi² statistic for the selected genes in the secondary trait, divided by the average statistic for all genes in the secondary trait. # genes⁺: Shared significant genes at Bonferroni correction. # genes⁺⁺: Shared significant genes at transcriptome-wide significance. % genes⁺⁺: Number of [++] genes as a percentage of primary trait’s total joint genes. corr: Correlation of effect sizes across the [+] genes.

Associations by panel

tissue	modality	# hits	% hits/tests	avg chisq
IL	alternative polyA	0	0.000	1.17
IL	intron excision ratio	0	0.000	1.10
OFC	alternative TSS	0	0.000	1.10
Eye	isoform ratio	0	0.000	1.09
OFC	alternative polyA	0	0.000	1.07
Eye	mRNA stability	0	0.000	1.06
Eye	alternative polyA	0	0.000	1.05
IL	alternative TSS	0	0.000	1.04
IL	isoform ratio	0	0.000	1.04
BLA	alternative TSS	0	0.000	1.03
Eye	gene expression	0	0.000	1.03
Eye	intron excision ratio	0	0.000	1.01
Adipose	isoform ratio	0	0.000	1.00
Adipose	gene expression	1	0.012	0.99
Liver	alternative TSS	0	0.000	0.99
PL	isoform ratio	0	0.000	0.99
BLA	mRNA stability	0	0.000	0.98
Brain	gene expression	0	0.000	0.98
Brain	mRNA stability	0	0.000	0.98
Liver	gene expression	0	0.000	0.98
NAcc	alternative TSS	0	0.000	0.98
PL	mRNA stability	0	0.000	0.98
BLA	alternative polyA	0	0.000	0.97
BLA	gene expression	0	0.000	0.97
IL	mRNA stability	0	0.000	0.97
LHb	mRNA stability	0	0.000	0.97
NAcc	isoform ratio	0	0.000	0.97
OFC	mRNA stability	0	0.000	0.97
PL	gene expression	0	0.000	0.97
Adipose	mRNA stability	0	0.000	0.96
BLA	intron excision ratio	0	0.000	0.96
Brain	alternative polyA	0	0.000	0.96
IL	gene expression	0	0.000	0.96
Liver	isoform ratio	0	0.000	0.96
OFC	gene expression	0	0.000	0.96
PL	alternative TSS	0	0.000	0.96
Adipose	alternative polyA	0	0.000	0.95
Brain	alternative TSS	0	0.000	0.95
Brain	isoform ratio	0	0.000	0.95
LHb	alternative polyA	0	0.000	0.95
LHb	gene expression	0	0.000	0.95
NAcc	gene expression	0	0.000	0.95
PL	alternative polyA	0	0.000	0.95
PL	intron excision ratio	0	0.000	0.95
BLA	isoform ratio	0	0.000	0.94
Liver	alternative polyA	0	0.000	0.94
Liver	mRNA stability	0	0.000	0.94
NAcc	mRNA stability	0	0.000	0.93
OFC	isoform ratio	0	0.000	0.93
Adipose	intron excision ratio	0	0.000	0.92
Brain	intron excision ratio	0	0.000	0.92
LHb	isoform ratio	0	0.000	0.92
Liver	intron excision ratio	0	0.000	0.92
NAcc	intron excision ratio	0	0.000	0.92
OFC	intron excision ratio	0	0.000	0.91
Adipose	alternative TSS	0	0.000	0.90
LHb	intron excision ratio	0	0.000	0.90
NAcc	alternative polyA	0	0.000	0.90
LHb	alternative TSS	0	0.000	0.85
Eye	alternative TSS	0	0.000	0.80

avg chisq: Average Chi² (squared Z-score) across all models in this panel for this trait.