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Latency to leave start box in cocaine runway, M

Latency to leave start box in cocaine runway task, male

Tags: Behavior · Cocaine

Project: u01_tom_jhou

2 loci · 2 genes with independent associations · 2 total associated genes

Significant Loci

#	Chr	Start pos	End pos	# assoc genes	# joint models	Best TWAS P	Best GWAS P	Cond GWAS P	Joint genes
1	chr1	163118025	164452706	1	1	2.33e-13	3.91e-01	1.00e+00	C1h11orf16
2	chr19	32676171	34074113	1	1	2.10e-10	1.69e-01	2.54e-03	Zdhhc1

Pleiotropic Associations

Trait	Chi2 ratio	# genes+	# genes++	% genes++	Corr	Corr P	Genes
BMI with tail	12.58	1	1	50	0	1e+00	C1h11orf16
BMI without tail	13.65	1	1	50	0	1e+00	C1h11orf16
Epididymis fat weight	3.94	1	0	0	0	1e+00	Zdhhc1
Left kidney weight	12.42	1	1	50	0	1e+00	Zdhhc1
Right kidney weight	12.86	1	1	50	0	1e+00	Zdhhc1
Length with tail	2.13	1	0	0	0	1e+00	C1h11orf16
Liver weight, left	13.18	1	0	0	0	1e+00	C1h11orf16
Liver weight, right	7.1	1	0	0	0	1e+00	C1h11orf16
Parametrial fat weight	9.49	1	0	0	0	1e+00	Zdhhc1
Retroperitoneal fat weight	2.69	1	0	0	0	1e+00	Zdhhc1
Intraocular pressure	4.8	2	0	0	0	1e+00	C1h11orf16 Zdhhc1
Patch foraging indifference point AUC	7.82	1	0	0	0	1e+00	Zdhhc1
Patch foraging total patch changes 12 sec	3.95	1	0	0	0	1e+00	Zdhhc1
Patch foraging total patch changes 18 sec	4.11	1	0	0	0	1e+00	Zdhhc1
Patch foraging total patch changes 24 sec	6.8	1	0	0	0	1e+00	Zdhhc1
Patch foraging total patch changes 6 sec	4.17	1	0	0	0	1e+00	Zdhhc1
Patch foraging water rate 18 sec	5.97	1	0	0	0	1e+00	Zdhhc1
Patch foraging water rate 6 sec	6.12	1	0	0	0	1e+00	Zdhhc1
Locomotor activity	8.53	1	0	0	0	1e+00	Zdhhc1
Locomotor testing rearing	6.23	1	0	0	0	1e+00	Zdhhc1
Light reinforcement 1	9.77	1	0	0	0	1e+00	Zdhhc1
Light reinforcement 2	4.91	1	0	0	0	1e+00	Zdhhc1
Reaction time number correct	6.37	1	0	0	0	1e+00	Zdhhc1
Reaction time mean minus median	17.11	1	0	0	0	1e+00	C1h11orf16
Reaction time mean minus median AUC	9.98	2	0	0	0	1e+00	C1h11orf16 Zdhhc1
Reaction time trials correct on left	6.37	1	0	0	0	1e+00	Zdhhc1
Reaction time trials on left	6.86	1	0	0	0	1e+00	Zdhhc1
Reaction time mean	24.17	1	1	50	0	1e+00	Zdhhc1
Reaction time mean AUC	19.64	1	0	0	0	1e+00	Zdhhc1
Median of all reaction times	26.45	1	1	50	0	1e+00	Zdhhc1
Reaction time omissions	5.39	1	0	0	0	1e+00	C1h11orf16
Std. dev. reaction times	10.22	2	0	0	0	1e+00	C1h11orf16 Zdhhc1
Reaction time trials completed	6.86	1	0	0	0	1e+00	Zdhhc1
Reaction time trials AUC	6.44	1	0	0	0	1e+00	Zdhhc1
Social response proportion	10.93	1	0	0	0	1e+00	Zdhhc1
Conditioned locomotion	5.5	1	0	0	0	1e+00	Zdhhc1
Pavlov. Cond. lever latency	6.92	1	0	0	0	1e+00	C1h11orf16
Pavlov. Cond. magazine entry latency	4.52	1	0	0	0	1e+00	C1h11orf16
Pavlov. Cond. index score	5.19	1	0	0	0	1e+00	C1h11orf16
Pavlov. Cond. latency score	7.07	1	0	0	0	1e+00	C1h11orf16
Pavlov. Cond. lever contacts	6.17	1	0	0	0	1e+00	C1h11orf16
Pavlov. Cond. magazine entry number	4.45	1	0	0	0	1e+00	C1h11orf16
Pavlov. Cond. lever-magazine prob. diff.	6.67	1	0	0	0	1e+00	C1h11orf16
Pavlov. Cond. response bias	6.74	1	0	0	0	1e+00	C1h11orf16
Conditioned reinforcement - actives	5.87	1	0	0	0	1e+00	C1h11orf16
Conditioned locomotion	6.11	1	0	0	0	1e+00	Zdhhc1
Intermittent access intake day 1-15 change	6.88	1	0	0	0	1e+00	C1h11orf16
Intermittent access intake escalation 2	17.78	1	0	0	0	1e+00	C1h11orf16
Intermitt. access day 15 inactive lever presses	8.46	1	0	0	0	1e+00	Zdhhc1
Intermittent access day 1 total infusions	10.04	1	0	0	0	1e+00	Zdhhc1
Intermittent access day 15 total infusions	14.11	1	0	0	0	1e+00	Zdhhc1
Intermittent access terminal intake (last 3 days)	7.65	1	0	0	0	1e+00	Zdhhc1
Intermittent access total infusions	13.02	1	0	0	0	1e+00	Zdhhc1
Intermittent access day 1 locomotion	11.85	1	0	0	0	1e+00	C1h11orf16
Intermittent access standard deviation	6.95	1	0	0	0	1e+00	C1h11orf16
Post-drug Anxiety	8.64	1	0	0	0	1e+00	Zdhhc1
Lifetime Intake	12.87	1	0	0	0	1e+00	Zdhhc1
Incentive Sensitization - Responses	17.61	2	1	50	0	1e+00	C1h11orf16 Zdhhc1
Incentive Sensitization - Breakpoint	18.19	2	1	50	0	1e+00	C1h11orf16 Zdhhc1
Progressive ratio test 1 active lever presses	11.58	1	0	0	0	1e+00	Zdhhc1
Progressive ratio test 1 breakpoint	4.95	1	0	0	0	1e+00	Zdhhc1
Progressive ratio test 1 inactive lever presses	7.68	2	0	0	0	1e+00	C1h11orf16 Zdhhc1
Progressive ratio test 2 active lever presses	26.53	1	1	50	0	1e+00	Zdhhc1
Progressive ratio test 2 breakpoint	20.83	1	0	0	0	1e+00	Zdhhc1
Progressive ratio test 2 inactive lever presses	5.31	1	0	0	0	1e+00	C1h11orf16
Total sessions with >9 infusions	31.3	2	1	50	0	1e+00	C1h11orf16 Zdhhc1
Short access day 10 total inactive lever presses	8.25	1	0	0	0	1e+00	Zdhhc1
Short access day 1 total infusions	19.14	1	0	0	0	1e+00	Zdhhc1
Short access day 10 total infusions	7.41	1	0	0	0	1e+00	Zdhhc1
Short access total infusions	8.06	1	0	0	0	1e+00	Zdhhc1
Short access total locomotion	10.39	1	0	0	0	1e+00	C1h11orf16
One hour access (0.3 mA shock)	7.77	1	0	0	0	1e+00	C1h11orf16
One hour access (shock baseline)	12.69	2	0	0	0	1e+00	C1h11orf16 Zdhhc1
Number of responses in last shaping day	13.54	1	0	0	0	1e+00	Zdhhc1
Locomotion distance, session 2	5.33	1	0	0	0	1e+00	C1h11orf16
Bone: apparent density	5.31	1	0	0	0	1e+00	C1h11orf16
Bone surface	3.9	1	0	0	0	1e+00	Zdhhc1
Bone volume	4.11	1	0	0	0	1e+00	Zdhhc1
Bone: cortical apparent density	15.5	1	0	0	0	1e+00	C1h11orf16
Bone: cortical tissue density	16.13	1	0	0	0	1e+00	C1h11orf16
Bone: tissue strength	14.55	1	0	0	0	1e+00	C1h11orf16
Bone: trabecular number	7.42	2	0	0	0	1e+00	C1h11orf16 Zdhhc1
Bone: trabecular spacing	15.64	1	0	0	0	1e+00	C1h11orf16
Bone: trabecular thickness	7.1	1	0	0	0	1e+00	C1h11orf16
Distance traveled before self-admin	33.93	2	1	50	0	1e+00	C1h11orf16 Zdhhc1
Delta time in open arm before/after self-admin	13.01	1	0	0	0	1e+00	Zdhhc1
Extinction: sum of active levers before priming	6.15	1	0	0	0	1e+00	Zdhhc1
Active lever presses in extinction session 6	10.03	1	0	0	0	1e+00	Zdhhc1
Delta distance traveled before/after self-admin	7.13	1	0	0	0	1e+00	C1h11orf16
Delta ambulatory time before/after self-admin	16.57	1	0	0	0	1e+00	Zdhhc1
Time in closed arm before self-admin	9.65	2	0	0	0	1e+00	C1h11orf16 Zdhhc1
Time in closed arm after self-admin	7.24	1	0	0	0	1e+00	Zdhhc1
Time in open arm before self-admin	6.28	1	0	0	0	1e+00	C1h11orf16
Time to tail flick, vehicle, before self-admin	18.85	1	0	0	0	1e+00	Zdhhc1
Time to tail flick, test, after self-admin	5.3	1	0	0	0	1e+00	Zdhhc1
Ambulatory time before self-admin	25.03	2	1	50	0	1e+00	C1h11orf16 Zdhhc1
Delay disc. indifference point, 0s delay	8.88	1	0	0	0	1e+00	C1h11orf16
Delay disc. indifference point, 16s delay	6.65	1	0	0	0	1e+00	C1h11orf16
Delay disc. indifference point, 2s delay	7.52	1	0	0	0	1e+00	Zdhhc1
Time >=10cm from walls, locomotor time 1	10.58	2	0	0	0	1e+00	C1h11orf16 Zdhhc1
Rest time, locomotor task time 1	5.83	1	0	0	0	1e+00	Zdhhc1
Distance moved, locomotor task time 1	5.4	1	0	0	0	1e+00	Zdhhc1
Vertical activity count, locomotor time 1	5.5	2	0	0	0	1e+00	C1h11orf16 Zdhhc1
Time >=10cm from walls, locomotor time 2	5.83	1	0	0	0	1e+00	Zdhhc1
Bouts of movement, locomotor time 2	5.03	1	0	0	0	1e+00	C1h11orf16
Rest time, locomotor task time 2	15.61	1	0	0	0	1e+00	Zdhhc1
Distance moved, locomotor task time 2	17.95	1	0	0	0	1e+00	Zdhhc1
Vertical activity count, locomotor time 2	11.34	1	0	0	0	1e+00	Zdhhc1
Seeking ratio, delayed vs. immediate footshock	18.76	1	0	0	0	1e+00	C1h11orf16
Locomotion in novel chamber post-restriction	12.81	1	0	0	0	1e+00	C1h11orf16
Progressive ratio	22.47	1	0	0	0	1e+00	Zdhhc1
Seeking ratio, punishment vs. effort	9.83	1	0	0	0	1e+00	Zdhhc1
Run reversals in cocaine runway, males	10.39	1	0	0	0	1e+00	C1h11orf16
Latency to leave start box in cocaine runway	4.69	1	0	0	0	1e+00	C1h11orf16
Latency to leave start box in cocaine runway, F	9.76	1	0	0	0	1e+00	Zdhhc1
Mn content in liver	12.13	1	0	0	0	1e+00	C1h11orf16
Se content in liver	8.47	1	0	0	0	1e+00	C1h11orf16
Sr content in liver	6.51	1	0	0	0	1e+00	C1h11orf16
Zn content in liver	14.97	1	0	0	0	1e+00	C1h11orf16

Associations by panel

Tissue	RNA modality	# hits	% hits/tests	Avg chisq
Adipose	alternative polyA	0	0	0.91
Adipose	alternative TSS	0	0	0.9
Adipose	gene expression	0	0	0.98
Adipose	isoform ratio	0	0	0.99
Adipose	intron excision ratio	0	0	0.92
Adipose	mRNA stability	0	0	0.98
BLA	alternative polyA	0	0	0.97
BLA	alternative TSS	0	0	1.04
BLA	gene expression	0	0	0.98
BLA	isoform ratio	0	0	0.95
BLA	intron excision ratio	0	0	0.92
BLA	mRNA stability	0	0	1
Brain	alternative polyA	0	0	0.92
Brain	alternative TSS	0	0	0.97
Brain	gene expression	0	0	0.99
Brain	isoform ratio	0	0	0.96
Brain	intron excision ratio	0	0	0.94
Brain	mRNA stability	0	0	0.99
Eye	alternative polyA	0	0	0.85
Eye	alternative TSS	0	0	1.2
Eye	gene expression	0	0	1.03
Eye	isoform ratio	0	0	1.03
Eye	intron excision ratio	0	0	0.94
Eye	mRNA stability	0	0	1.01
IL	alternative polyA	0	0	0.96
IL	alternative TSS	0	0	1.01
IL	gene expression	0	0	0.95
IL	isoform ratio	0	0	0.98
IL	intron excision ratio	0	0	0.96
IL	mRNA stability	0	0	1
LHb	alternative polyA	0	0	0.88
LHb	alternative TSS	0	0	0.96
LHb	gene expression	0	0	0.93
LHb	isoform ratio	0	0	0.96
LHb	intron excision ratio	0	0	0.84
LHb	mRNA stability	0	0	0.97
Liver	alternative polyA	0	0	0.93
Liver	alternative TSS	0	0	0.98
Liver	gene expression	0	0	0.95
Liver	isoform ratio	0	0	0.96
Liver	intron excision ratio	0	0	0.91
Liver	mRNA stability	0	0	0.99
NAcc	alternative polyA	0	0	0.9
NAcc	alternative TSS	0	0	1
NAcc	gene expression	1	0	0.98
NAcc	isoform ratio	0	0	0.97
NAcc	intron excision ratio	0	0	0.94
NAcc	mRNA stability	1	0	0.99
OFC	alternative polyA	0	0	0.92
OFC	alternative TSS	0	0	1.09
OFC	gene expression	0	0	0.97
OFC	isoform ratio	0	0	0.96
OFC	intron excision ratio	0	0	0.88
OFC	mRNA stability	0	0	0.96
PL	alternative polyA	0	0	0.94
PL	alternative TSS	0	0	1.04
PL	gene expression	0	0	0.97
PL	isoform ratio	0	0	0.98
PL	intron excision ratio	0	0	0.94
PL	mRNA stability	0	0	1.01
pVTA	alternative polyA	0	0	0.89
pVTA	alternative TSS	0	0	1
pVTA	gene expression	0	0	0.97
pVTA	isoform ratio	0	0	0.96
pVTA	intron excision ratio	0	0	0.9
pVTA	mRNA stability	0	0	0.95
RMTg	alternative polyA	0	0	0.97
RMTg	alternative TSS	0	0	1.03
RMTg	gene expression	0	0	1.01
RMTg	isoform ratio	0	0	0.94
RMTg	intron excision ratio	0	0	0.86
RMTg	mRNA stability	0	0	1.07