Hub : Genes

Ucp2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 PL gene expression Ucp2 0.09 0.07 2.8e-08 0.06 0.07 0.08 0.08 1.1e-06 3.5e-08 2.9e-09 2.2e-09
2 Eye gene expression Ucp2 0.72 0.15 1.9e-07 0.08 0.18 0.09 0.13 2.2e-02 1.1e-03 1.8e-02 5.6e-03
3 BLA gene expression Ucp2 0.37 0.17 5.0e-16 0.26 0.26 0.26 0.27 5.4e-14 9.3e-14 2.4e-14 1.3e-14
4 NAcc gene expression Ucp2 0.07 0.04 3.0e-11 0.04 0.07 0.07 0.07 2.5e-07 1.9e-11 1.2e-10 1.5e-10
5 LHb gene expression Ucp2 0.17 0.12 6.5e-03 -0.01 0.01 0 -0.01 4.9e-01 1.9e-01 3.0e-01 6.0e-01
6 IC gene expression Ucp2 0.33 0.13 7.0e-14 0.17 0.25 0.24 0.22 8.3e-08 6.6e-11 1.7e-10 7.9e-10
7 Brain gene expression Ucp2 0.47 0.19 0.0e+00 0.43 0.43 0.43 0.43 3.9e-43 1.2e-43 3.8e-43 2.5e-43
8 OFC mRNA stability Ucp2 0.18 0.12 1.8e-03 0.05 0.03 -0.01 0.04 2.9e-02 5.8e-02 6.5e-01 5.2e-02
9 Adipose gene expression Ucp2 0.12 0.07 3.8e-13 0.11 0.11 0.1 0.1 5.2e-12 9.1e-12 2.1e-11 3.1e-11
10 pVTA gene expression Ucp2 0.17 0.09 4.7e-14 0.08 0.16 0.16 0.16 3.9e-07 1.0e-12 1.7e-12 8.6e-13
11 Liver gene expression Ucp2 0.04 0.03 1.1e-04 0.03 0.03 0.03 0.03 1.5e-04 8.4e-04 2.6e-04 5.1e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11
Bone: apparent density0.00.10.10.30.40.30.30.30.20.00.20.2-0.20.1
Area under the delay curve0.10.10.20.10.20.40.20.30.30.3-0.3-0.30.3-0.4
BMI with tail0.31.12.40.60.30.80.40.60.71.2-1.5-1.51.4-1.4
BMI without tail0.10.61.6-0.0-0.40.1-0.3-0.00.10.7-1.3-1.21.1-1.0
Body weight0.31.53.60.60.10.70.30.50.71.4-1.8-1.91.7-1.8
Weight adjusted by age0.00.00.2-0.2-0.20.1-0.1-0.10.00.2-0.2-0.40.2-0.4
Bone surface0.40.81.1-1.0-1.0-0.9-1.0-1.0-1.0-0.80.70.7-0.70.7
Bone volume0.20.40.5-0.7-0.7-0.5-0.7-0.6-0.6-0.60.50.5-0.50.5
Breakpoint value in progressive ratio session0.20.30.80.70.90.70.90.70.60.3-0.3-0.10.2-0.2
Number of licking bursts2.67.89.22.92.93.02.92.92.92.8-2.6-2.62.6-2.7
Context. condit. distance diff. score3.44.24.9-2.1-2.0-2.2-2.0-2.1-2.1-2.11.92.0-2.02.0
Locomotion velocity, session 10.10.10.20.00.20.00.20.1-0.0-0.30.50.4-0.40.4
Locomotion distance, session 11.41.82.0-1.4-1.2-1.4-1.2-1.3-1.3-1.41.41.4-1.41.3
Locomotion velocity, session 20.00.00.1-0.2-0.3-0.2-0.2-0.2-0.2-0.10.10.1-0.10.1
Locomotion distance, session 20.70.91.1-1.0-0.9-1.0-0.9-0.9-1.0-0.91.00.9-0.90.9
Locomotion velocity, session 31.41.61.9-1.2-1.1-1.2-1.1-1.2-1.2-1.31.41.4-1.41.3
Locomotion distance, session 32.32.63.2-1.6-1.4-1.6-1.4-1.5-1.6-1.71.81.8-1.81.7
Stereotopy head waving bouts, day 30.81.01.21.00.81.00.90.91.01.0-1.1-1.11.1-1.1
Stereotopy head waving duration, day 30.20.20.2-0.5-0.4-0.5-0.4-0.4-0.5-0.50.50.5-0.50.5
Locomotion velocity, session 70.10.10.20.30.40.30.40.30.30.1-0.1-0.00.00.0
Locomotion distance, session 70.20.20.20.50.50.50.50.50.50.4-0.4-0.40.4-0.4
Stereotopy head waving bouts, day 73.84.45.0-2.2-2.1-2.2-2.1-2.1-2.1-2.12.02.0-2.02.0
Stereotopy head waving duration, day 73.74.55.4-2.3-2.2-2.3-2.2-2.2-2.2-2.11.91.9-1.91.9
Locomotion velocity, session 81.01.21.4-1.2-1.1-1.2-1.1-1.1-1.1-1.11.01.0-1.01.0
Locomotion distance, session 83.14.55.6-2.3-2.2-2.4-2.2-2.2-2.2-2.11.91.9-1.91.9
Degree of sensitization distance2.32.53.61.51.11.51.21.31.41.7-1.9-1.91.9-1.8
Degree of sensitization stereotypy7.48.29.6-3.1-2.9-3.1-2.9-3.0-2.9-2.82.72.7-2.72.7
Conditioned locomotion0.00.00.1-0.00.1-0.10.1-0.0-0.1-0.20.30.4-0.40.3
Cocaine response after cond. corrected2.23.33.71.91.71.91.81.81.81.8-1.9-1.81.8-1.8
Cocaine response after cond. not corrected0.50.81.00.90.80.90.80.90.90.9-1.0-0.80.8-0.8
Cocaine response before conditioning3.44.14.4-2.1-1.9-2.1-1.9-2.0-2.0-2.12.02.1-2.12.1
Saline control response1.01.32.2-1.3-1.5-1.3-1.4-1.3-1.3-1.00.80.8-0.80.8
Bone: connectivity density0.10.20.4-0.2-0.1-0.2-0.1-0.2-0.3-0.50.70.7-0.70.6
Bone: cortical apparent density2.13.34.02.01.92.01.91.91.91.8-1.6-1.61.6-1.7
Bone: cortical area0.00.00.1-0.2-0.3-0.1-0.2-0.1-0.10.1-0.2-0.20.2-0.2
Bone: cortical porosity1.31.41.7-1.1-1.0-1.2-1.0-1.1-1.1-1.31.21.2-1.21.3
Bone: cortical porosity1.41.61.9-1.2-1.1-1.3-1.1-1.2-1.2-1.41.31.3-1.31.4
Bone: cortical thickness0.20.40.60.70.80.70.70.70.70.5-0.4-0.40.4-0.5
Bone: cortical thickness0.20.20.3-0.5-0.4-0.5-0.4-0.5-0.5-0.50.50.5-0.50.5
Bone: cortical tissue density2.03.13.71.91.91.91.91.91.81.7-1.5-1.51.5-1.6
Condit. Reinf. active minus inactive responses0.00.00.1-0.1-0.2-0.0-0.2-0.1-0.00.2-0.3-0.30.3-0.3
Condit. Reinf. active-inactive response ratio0.10.10.3-0.3-0.5-0.3-0.5-0.4-0.3-0.0-0.1-0.10.1-0.2
Condit. Reinf. active responses0.00.10.10.10.10.20.10.10.20.3-0.3-0.30.3-0.3
Condit. Reinf. inactive responses0.00.00.00.10.20.10.10.10.10.00.00.0-0.00.0
Incentive salience index mean0.00.00.1-0.2-0.3-0.2-0.3-0.2-0.20.0-0.1-0.10.1-0.1
Condit. Reinf. lever presses0.10.10.2-0.5-0.5-0.4-0.5-0.4-0.4-0.30.30.3-0.30.2
Condit. Reinf. active minus inactive responses3.85.89.3-2.9-3.0-2.7-3.0-2.8-2.6-2.01.81.7-1.71.7
Condit. Reinf. active-inactive response ratio0.81.31.9-1.4-1.4-1.3-1.4-1.3-1.2-1.00.90.9-0.90.9
Condit. Reinf. active responses5.27.512.7-3.3-3.6-3.1-3.4-3.2-3.0-2.32.01.8-1.81.8
Condit. Reinf. inactive responses2.33.36.1-2.2-2.5-2.1-2.4-2.2-2.0-1.51.21.1-1.11.1
Condit. Reinf. lever presses13.119.027.2-5.0-5.2-4.8-5.1-4.9-4.7-3.93.53.4-3.33.3
Condit. Reinf. lever reinforcers received6.59.114.8-3.6-3.8-3.4-3.7-3.5-3.3-2.52.22.1-2.02.0
Conditioned reinforcement - actives0.83.23.6-1.9-1.8-1.9-1.8-1.8-1.8-1.81.61.7-1.71.8
Conditioned reinforcement - inactives0.00.10.20.40.40.30.40.30.30.2-0.4-0.30.2-0.1
Conditioned locomotion4.36.48.0-2.5-2.2-2.5-2.3-2.4-2.4-2.62.62.7-2.82.7
Patch foraging indifference point 0 sec2.15.97.4-2.7-2.7-2.6-2.7-2.6-2.6-2.32.22.1-2.02.1
Patch foraging indifference point AUC0.10.30.80.30.10.40.20.30.40.6-0.7-0.90.8-0.7
Delay disc. indifference point, 0s delay0.80.91.3-1.1-1.1-1.0-1.1-1.0-1.0-0.80.70.7-0.70.6
Delay disc. indifference point, 16s delay0.00.00.10.10.20.30.20.20.20.1-0.0-0.00.1-0.1
Delay disc. indifference point, 2s delay0.10.10.4-0.5-0.6-0.3-0.6-0.5-0.4-0.1-0.00.00.0-0.1
Delay disc. indifference point, 24s delay0.61.01.61.01.21.31.21.11.00.9-0.7-0.70.8-0.8
Delay disc. indifference point, 4s delay0.20.20.5-0.6-0.7-0.3-0.6-0.5-0.4-0.0-0.1-0.10.2-0.2
Delay disc. indifference point, 8s delay0.00.00.0-0.10.10.10.10.10.10.1-0.1-0.10.1-0.2
Indifference point function ln k1.33.95.4-1.9-1.6-1.9-1.7-1.8-1.9-2.12.22.3-2.12.1
Indifference point function log k1.33.95.4-1.9-1.6-1.9-1.7-1.8-1.9-2.12.22.3-2.12.1
Patch foraging total patch changes 0 sec1.54.55.8-2.4-2.4-2.3-2.4-2.3-2.3-2.01.91.8-1.71.8
Patch foraging total patch changes 12 sec0.20.20.7-0.6-0.8-0.5-0.7-0.6-0.5-0.10.1-0.10.2-0.1
Patch foraging total patch changes 18 sec0.81.93.1-1.6-1.8-1.6-1.7-1.6-1.5-1.20.90.7-0.91.0
Patch foraging total patch changes 24 sec0.10.20.7-0.6-0.8-0.5-0.8-0.6-0.5-0.2-0.1-0.10.10.0
Patch foraging total patch changes 6 sec0.50.91.1-1.1-1.0-0.9-1.0-1.0-1.0-0.81.00.8-0.60.8
Patch foraging time to switch 0 sec1.14.25.92.42.42.22.42.32.21.8-1.6-1.71.5-1.5
Patch foraging water rate 0 sec1.34.96.5-2.5-2.5-2.3-2.4-2.4-2.3-2.11.91.9-1.81.9
Patch foraging water rate 12 sec1.04.14.8-2.2-2.1-2.1-2.1-2.1-2.1-2.01.81.9-1.92.0
Patch foraging water rate 18 sec0.61.31.9-1.3-1.4-1.3-1.3-1.3-1.2-1.00.71.0-0.90.8
Patch foraging water rate 24 sec2.23.14.0-1.8-1.5-1.7-1.6-1.7-1.7-1.82.01.9-1.81.8
Patch foraging water rate 6 sec1.52.22.4-1.5-1.4-1.6-1.5-1.5-1.5-1.51.51.4-1.51.5
Seeking ratio, delayed vs. immediate footshock0.50.71.31.11.10.71.11.00.90.6-0.8-0.60.3-0.4
Distance traveled before self-admin0.61.21.51.21.21.21.21.21.21.1-1.0-0.91.1-1.0
Distance traveled after self-admin0.10.20.50.20.4-0.10.30.20.0-0.40.70.6-0.70.6
Extensor digitorum longus weight0.51.82.81.20.91.21.01.11.21.5-1.7-1.61.6-1.6
Bone: elastic displacement1.01.32.41.41.51.31.51.41.30.9-0.7-0.70.7-0.6
Bone: elastic work0.91.12.31.31.51.21.41.31.20.8-0.6-0.60.6-0.5
Bone: endosteal estimation0.20.61.7-1.0-1.3-0.8-1.2-1.0-0.9-0.30.00.0-0.00.1
Bone: endosteal perimeter0.41.12.6-1.3-1.6-1.1-1.5-1.3-1.2-0.60.30.3-0.30.4
Epididymis fat weight0.31.72.11.31.21.31.21.21.21.3-1.4-1.41.3-1.1
Delta time in closed arm before/after self-admin4.34.15.51.91.61.91.71.81.92.1-2.3-2.32.3-2.2
Delta time in open arm before/after self-admin1.82.13.1-1.6-1.7-1.7-1.7-1.6-1.6-1.30.91.0-1.21.2
Diff in mean of infusions in LGA sessions3.25.77.12.62.72.52.62.62.52.2-2.2-2.12.1-2.0
Delay discount exponential model param0.10.10.2-0.1-0.2-0.5-0.3-0.3-0.3-0.40.30.3-0.40.4
Extinction: sum of active levers before priming0.00.00.1-0.0-0.1-0.0-0.0-0.00.00.1-0.3-0.20.0-0.2
Active lever presses in extinction session 65.45.58.4-2.1-1.7-2.2-1.8-2.0-2.1-2.42.92.9-2.72.6
Bone: final force0.10.10.20.40.40.40.40.40.30.3-0.3-0.30.3-0.3
Bone: final moment0.00.00.00.20.20.20.20.20.20.2-0.2-0.20.2-0.2
Food consumed during 24 hour testing period3.05.96.7-2.6-2.5-2.6-2.5-2.5-2.5-2.42.42.3-2.32.3
Glucose0.00.00.10.20.20.20.20.20.20.2-0.1-0.20.2-0.2
Heart weight0.91.51.9-1.4-1.3-1.4-1.3-1.3-1.3-1.21.11.1-1.11.1
Delay discount hyperbolic model param0.10.10.3-0.1-0.2-0.5-0.2-0.3-0.3-0.40.40.4-0.40.5
Intermittent access intake day 1-15 change0.21.11.8-1.1-0.9-1.0-1.0-1.0-1.0-1.01.31.3-1.10.9
Intermittent access intake escalation0.31.52.2-1.3-1.1-1.2-1.1-1.2-1.2-1.21.51.4-1.21.1
Intermittent access intake escalation 20.50.91.3-1.0-0.9-0.9-0.9-0.9-0.9-0.81.21.1-0.70.7
Intermitt. access day 1 inactive lever presses0.22.12.51.61.41.51.51.51.51.4-1.5-1.41.2-1.3
Intermitt. access day 15 inactive lever presses0.00.20.50.60.70.60.70.60.50.2-0.2-0.20.00.0
Intermitt. access escalation Index0.00.00.1-0.2-0.2-0.1-0.2-0.2-0.2-0.10.30.2-0.20.0
Intermittent access day 1 total infusions0.82.53.3-1.7-1.7-1.8-1.7-1.7-1.7-1.61.11.1-1.61.7
Intermittent access day 15 total infusions1.33.33.7-1.9-1.8-1.9-1.8-1.8-1.8-1.81.71.7-1.81.8
Intermittent access terminal intake (last 3 days)2.13.64.2-2.1-1.9-2.0-2.0-2.0-2.0-1.91.81.8-1.91.8
Intermittent access total infusions2.22.63.3-1.7-1.8-1.8-1.8-1.7-1.7-1.61.11.2-1.51.5
Intermittent access day 1 locomotion0.40.71.2-0.8-0.7-0.9-0.7-0.8-0.8-0.90.80.7-1.11.1
Intermittent access day 15 total locomotion0.72.73.4-1.6-1.4-1.7-1.5-1.5-1.6-1.71.81.7-1.81.8
Intermittent access total locomotion1.41.72.2-1.3-1.2-1.4-1.3-1.3-1.3-1.41.11.1-1.51.4
Intermittent access standard deviation0.00.00.2-0.1-0.10.1-0.1-0.0-0.00.2-0.1-0.10.4-0.4
Left kidney weight0.10.51.20.1-0.10.3-0.00.20.30.8-0.9-1.01.1-1.1
Right kidney weight0.10.61.40.1-0.30.2-0.10.10.30.8-1.0-1.21.2-1.2
Cocaine induced anxiety0.71.82.61.51.61.61.61.51.41.2-1.0-0.91.2-1.1
Post-drug Anxiety2.32.63.21.81.81.81.81.71.71.5-1.4-1.31.5-1.4
Baseline Anxiety0.00.10.2-0.3-0.4-0.4-0.4-0.4-0.3-0.2-0.0-0.0-0.20.1
Tail length0.10.82.0-0.0-0.50.1-0.3-0.10.20.9-1.3-1.31.4-1.3
Length with tail0.10.61.50.1-0.40.1-0.2-0.00.20.8-1.1-1.21.1-1.1
Length without tail0.10.40.60.60.60.60.60.60.60.6-0.6-0.80.6-0.6
Times rat made contact with spout0.91.01.40.90.81.00.80.90.91.1-1.2-1.11.1-1.2
Lifetime Intake2.63.24.3-1.9-2.0-2.1-2.0-2.0-1.9-1.81.21.3-1.61.7
Liver weight, left0.61.01.70.80.50.90.60.70.81.1-1.3-1.21.3-1.2
Liver weight, right2.34.15.61.91.51.91.61.81.92.2-2.2-2.42.4-2.2
Locomotor activity0.71.11.5-1.2-1.0-1.0-1.0-1.0-1.0-1.01.21.2-0.90.9
Locomotor testing distance0.71.62.6-1.6-1.6-1.4-1.5-1.4-1.4-1.11.11.0-0.80.9
Locomotor testing rearing0.00.10.3-0.5-0.6-0.2-0.5-0.4-0.30.1-0.1-0.20.3-0.3
Locomotion in novel chamber1.41.93.9-1.3-1.0-1.2-1.1-1.1-1.2-1.31.82.0-1.31.4
Locomotion in novel chamber post-restriction1.23.84.5-2.0-1.9-2.1-1.9-2.0-1.9-1.91.91.9-1.82.0
Fecal boli incidents, locomotor time 10.71.72.4-1.2-1.1-1.3-1.1-1.2-1.2-1.31.51.5-1.51.4
Change in fecal boli incidents, locomotor task0.91.01.21.11.01.01.01.01.01.0-1.0-1.01.0-0.9
Time >=10cm from walls, locomotor time 12.63.23.6-1.9-1.7-1.8-1.8-1.8-1.8-1.81.81.8-1.81.8
Bouts of movement, locomotor time 10.20.30.4-0.5-0.5-0.5-0.6-0.6-0.6-0.50.60.6-0.60.5
Total resting periods, locomotor time 10.40.50.8-0.5-0.5-0.6-0.5-0.6-0.6-0.80.90.8-0.90.8
Rest time, locomotor task time 10.10.20.5-0.1-0.1-0.4-0.1-0.2-0.3-0.50.60.5-0.60.7
Distance moved, locomotor task time 10.10.30.80.20.10.60.20.30.40.7-0.7-0.70.7-0.9
Vertical activity count, locomotor time 10.00.10.2-0.3-0.3-0.1-0.2-0.2-0.10.2-0.4-0.30.4-0.3
Time >=10cm from walls, locomotor time 20.51.32.0-1.4-1.4-1.3-1.4-1.3-1.3-1.10.80.8-0.80.9
Bouts of movement, locomotor time 20.00.10.2-0.1-0.30.1-0.2-0.1-0.00.3-0.3-0.30.3-0.5
Total resting periods, locomotor time 20.00.20.40.30.00.30.10.20.30.5-0.5-0.50.6-0.6
Rest time, locomotor task time 21.72.93.92.02.01.71.91.81.81.5-1.5-1.61.5-1.2
Distance moved, locomotor task time 21.72.33.6-1.9-1.9-1.6-1.8-1.7-1.7-1.31.21.2-1.11.0
Vertical activity count, locomotor time 20.20.51.1-1.0-1.1-0.8-1.0-0.9-0.8-0.50.30.3-0.30.3
Light reinforcement 11.04.45.22.32.32.32.32.22.22.0-2.0-2.01.9-1.7
Light reinforcement 20.00.10.20.40.40.30.40.30.30.1-0.10.0-0.10.1
Bone: marrow area0.20.41.3-0.8-1.1-0.6-1.0-0.8-0.7-0.2-0.1-0.10.1-0.1
Bone: maximum diameter0.51.02.1-1.3-1.5-1.1-1.4-1.2-1.1-0.70.50.5-0.50.5
Bone: maximum force0.00.00.00.20.20.20.20.20.20.1-0.1-0.10.1-0.1
Bone: maximum moment0.00.00.00.0-0.0-0.0-0.0-0.0-0.0-0.0-0.0-0.00.0-0.0
Mean time between licks in bursts0.21.43.5-1.5-1.9-1.4-1.7-1.5-1.3-0.60.10.2-0.20.2
Mean num. licks in bursts2.26.06.9-2.6-2.6-2.6-2.6-2.5-2.5-2.42.32.2-2.22.3
Cd content in liver0.90.91.21.00.80.90.80.90.91.0-1.1-1.11.1-1.1
Co content in liver0.40.51.1-0.9-1.1-0.8-1.0-0.9-0.8-0.50.20.3-0.30.3
Cu content in liver0.20.30.70.1-0.20.1-0.10.00.10.5-0.8-0.80.8-0.8
Fe content in liver0.00.00.10.20.20.10.20.20.20.2-0.2-0.20.2-0.2
K content in liver0.40.40.60.60.50.60.50.60.60.7-0.7-0.80.8-0.8
Mg content in liver0.10.10.1-0.3-0.3-0.3-0.3-0.3-0.3-0.20.10.1-0.10.1
Mn content in liver0.20.20.70.60.80.60.70.60.50.20.00.0-0.00.0
Na content in liver0.50.60.7-0.9-0.8-0.8-0.8-0.8-0.8-0.70.60.6-0.60.6
Rb content in liver0.30.30.4-0.6-0.7-0.7-0.6-0.6-0.6-0.50.40.4-0.40.4
Se content in liver3.03.65.62.22.42.12.32.22.11.6-1.4-1.41.4-1.4
Sr content in liver0.40.30.4-0.5-0.4-0.5-0.4-0.5-0.5-0.60.60.6-0.60.6
Zn content in liver1.41.73.0-1.6-1.7-1.5-1.7-1.5-1.4-1.10.80.8-0.80.8
Bone: minimum diameter0.20.41.00.2-0.20.3-0.10.10.30.8-1.0-1.01.0-1.0
Time in familiar zone, hab. session 10.10.10.20.30.10.30.20.20.30.4-0.5-0.50.5-0.4
Time in novel zone, hab. session 10.20.30.30.60.60.60.60.60.50.5-0.4-0.40.4-0.4
Total zone transitions, hab. session 10.20.30.5-0.4-0.2-0.5-0.3-0.4-0.4-0.60.70.7-0.70.7
Total locomotion distance, hab. session 11.82.63.31.51.31.51.31.41.51.7-1.8-1.81.8-1.8
Locomotion velocity, hab. session 11.01.41.91.10.91.11.01.11.11.3-1.3-1.31.3-1.4
Time in familiar zone, hab. session 21.11.21.9-1.3-1.4-1.3-1.3-1.3-1.2-1.00.70.8-0.80.7
Time in novel zone, hab. session 20.20.20.40.50.60.60.60.50.50.3-0.1-0.10.1-0.1
Total zone transitions, hab. session 22.22.83.1-1.7-1.5-1.7-1.6-1.6-1.7-1.71.71.7-1.71.7
Total locomotion distance, hab. session 20.40.61.10.50.30.50.30.50.60.9-1.0-1.11.1-1.0
Locomotion velocity, hab. session 20.71.01.70.70.50.80.60.70.81.1-1.3-1.31.3-1.3
Novel to familiar place preference ratio0.10.10.1-0.3-0.3-0.3-0.3-0.3-0.3-0.30.20.3-0.30.3
Novelty place preference0.10.10.1-0.3-0.3-0.3-0.3-0.3-0.3-0.30.20.3-0.30.3
Time in novel zone, NPP test0.20.20.3-0.5-0.5-0.5-0.5-0.5-0.5-0.50.50.5-0.50.5
Total zone transitions, NPP test0.40.60.9-0.7-0.6-0.8-0.6-0.7-0.7-0.80.90.9-0.90.9
Total locomotion distance, NPP test1.11.52.01.10.91.21.01.11.21.4-1.4-1.41.4-1.4
Locomotion velocity, NPP test1.62.32.81.51.31.51.31.41.51.6-1.6-1.71.7-1.7
Intraocular pressure0.40.61.1-0.7-0.5-0.6-0.5-0.6-0.6-0.81.10.9-0.90.9
Delta distance traveled before/after self-admin3.13.44.4-1.7-1.6-1.9-1.7-1.7-1.8-1.92.01.9-2.12.0
Delta ambulatory time before/after self-admin2.13.54.9-1.7-1.6-1.9-1.7-1.8-1.8-2.02.01.9-2.22.1
Parametrial fat weight0.92.22.51.61.41.51.41.51.51.4-1.6-1.61.5-1.3
Pavlov. Cond. lever latency1.21.52.11.41.51.41.41.41.31.1-1.0-1.01.0-1.0
Pavlov. Cond. magazine entry latency2.63.44.9-2.1-2.2-2.1-2.2-2.1-2.0-1.71.41.4-1.41.4
Pavlov. Cond. change in total contacts1.21.31.8-1.3-1.4-1.3-1.3-1.3-1.2-1.00.80.8-0.80.8
Pavlov. Cond. index score2.22.84.1-2.0-2.0-1.9-2.0-1.9-1.8-1.51.31.3-1.31.3
Pavlov. Cond. latency score2.22.84.0-1.9-2.0-1.9-2.0-1.9-1.8-1.51.31.3-1.31.3
Pavlov. Cond. lever contacts0.91.11.7-1.3-1.3-1.2-1.3-1.2-1.2-0.90.80.8-0.80.8
Pavlov. Cond. magazine entry number2.83.65.12.22.32.12.22.12.01.7-1.5-1.51.5-1.5
Pavlov. Cond. intertrial magazine entries0.70.81.21.11.11.01.11.01.00.8-0.7-0.60.6-0.7
Pavlov. Cond. lever-magazine prob. diff.1.82.33.3-1.8-1.8-1.7-1.8-1.7-1.6-1.41.11.1-1.11.1
Pavlov. Cond. response bias1.21.52.2-1.4-1.5-1.4-1.5-1.4-1.3-1.10.90.9-0.90.9
Pavlov. Cond. lever latency15.722.029.95.35.55.25.45.25.04.3-3.9-3.83.7-3.7
Pavlov. Cond. magazine entry latency4.36.07.1-2.7-2.6-2.7-2.6-2.6-2.6-2.42.32.2-2.22.2
Pavlov. Cond. change in total contacts7.117.322.9-4.7-4.8-4.6-4.7-4.6-4.4-3.93.63.4-3.43.4
Pavlov. Cond. index score10.716.822.3-4.6-4.7-4.5-4.6-4.5-4.4-3.83.53.3-3.33.3
Pavlov. Cond. latency score9.315.019.7-4.4-4.4-4.3-4.4-4.2-4.1-3.63.33.2-3.23.2
Pavlov. Cond. lever contacts14.020.628.2-5.2-5.3-5.0-5.2-5.0-4.8-4.23.83.6-3.63.6
Pavlov. Cond. magazine entry number8.010.312.33.53.53.53.53.43.33.1-3.0-2.82.8-2.8
Pavlov. Cond. intertrial magazine entries0.20.51.20.40.20.50.30.40.50.8-1.1-1.01.0-1.0
Pavlov. Cond. lever-magazine prob. diff.9.815.120.5-4.4-4.5-4.3-4.4-4.3-4.1-3.63.23.1-3.13.1
Pavlov. Cond. response bias16.122.229.5-5.3-5.4-5.2-5.3-5.2-5.0-4.44.03.8-3.83.8
Time in closed arm before self-admin2.64.56.1-2.1-1.8-2.1-1.9-1.9-2.0-2.22.52.4-2.12.2
Time in closed arm after self-admin0.20.20.60.60.80.50.70.60.50.30.0-0.10.2-0.1
Time in open arm before self-admin3.94.75.72.32.32.42.32.32.22.1-2.0-1.82.0-2.1
Time in open arm after self-admin0.20.20.50.2-0.00.20.00.10.20.5-0.7-0.60.5-0.6
Bone: periosteal estimation0.20.41.1-0.8-1.1-0.6-1.0-0.8-0.7-0.2-0.0-0.00.00.0
Bone: periosteal perimeter0.20.41.2-0.9-1.1-0.7-1.0-0.9-0.7-0.30.10.1-0.10.1
Bone: post-yield work0.00.00.0-0.2-0.2-0.1-0.2-0.1-0.1-0.10.00.0-0.00.0
Progressive ratio test 1 active lever presses0.10.10.4-0.2-0.2-0.4-0.2-0.3-0.3-0.50.20.2-0.50.6
Progressive ratio test 1 breakpoint0.10.10.3-0.2-0.1-0.3-0.2-0.2-0.3-0.40.20.2-0.40.6
Progressive ratio test 1 inactive lever presses0.00.10.3-0.1-0.0-0.3-0.1-0.1-0.2-0.3-0.3-0.2-0.30.5
Progressive ratio test 2 active lever presses0.30.40.6-0.8-0.8-0.7-0.8-0.8-0.7-0.60.40.4-0.50.6
Progressive ratio test 2 breakpoint0.40.50.7-0.8-0.8-0.8-0.8-0.8-0.8-0.70.40.4-0.50.6
Progressive ratio test 2 inactive lever presses0.20.71.1-0.9-0.8-0.9-0.8-0.8-0.9-0.90.60.6-0.91.1
Incentive Sensitization - Responses0.20.61.1-1.1-1.0-0.9-1.0-0.9-0.9-0.70.60.6-0.40.5
Incentive Sensitization - Breakpoint0.30.71.1-1.1-1.0-0.9-1.0-0.9-0.9-0.70.70.7-0.50.5
Sum of active levers in priming session hrs 5-60.10.10.2-0.10.0-0.0-0.0-0.1-0.1-0.30.20.5-0.40.3
Progressive ratio0.30.81.1-0.9-0.8-1.0-0.8-0.8-0.9-0.90.91.0-1.11.0
Food seeking constrained by brief footshock0.40.41.0-0.9-1.0-0.7-0.9-0.8-0.7-0.40.30.4-0.30.2
Seeking ratio, punishment vs. effort0.10.30.70.0-0.20.2-0.10.00.20.5-0.7-0.80.8-0.7
Retroperitoneal fat weight3.817.221.43.93.54.13.63.83.94.3-4.6-4.64.6-4.4
Reaction time number correct0.31.12.4-0.8-0.5-0.8-0.6-0.7-0.8-1.11.41.6-1.31.2
Reaction time mean minus median0.10.50.9-0.8-0.9-0.8-0.9-0.8-0.7-0.50.40.4-0.50.3
Reaction time mean minus median AUC0.21.51.8-1.3-1.3-1.3-1.3-1.3-1.3-1.21.11.0-1.11.0
Reaction time num false alarms2.23.74.11.91.92.01.92.02.02.0-1.9-1.81.9-1.9
Reaction time num false alarms AUC0.71.71.91.31.31.41.31.31.31.3-1.3-1.11.3-1.3
Reaction time trials correct on left0.31.12.4-0.8-0.5-0.8-0.6-0.7-0.8-1.11.41.6-1.31.2
Reaction time trials on left0.31.12.5-0.8-0.5-0.8-0.6-0.7-0.8-1.11.41.6-1.31.2
Reaction time mean0.81.72.01.31.21.31.21.31.31.3-1.4-1.31.2-1.3
Reaction time mean AUC0.81.82.11.41.41.41.41.41.41.3-1.4-1.31.2-1.2
Median of all reaction times1.62.52.81.71.61.61.61.61.61.6-1.7-1.51.4-1.5
Reaction time omissions0.30.40.70.50.50.60.50.60.60.7-0.8-0.80.7-0.8
Reaction time false alarm rate2.33.13.71.71.61.71.61.71.71.8-1.9-1.91.9-1.8
Reaction time premature initiation rate0.20.30.7-0.4-0.8-0.4-0.7-0.5-0.30.2-0.6-0.60.4-0.5
Reaction time premature initiations0.20.61.3-0.9-1.1-0.9-1.1-1.0-0.9-0.60.40.5-0.40.3
Std. dev. reaction times0.10.30.70.1-0.00.30.00.20.30.6-0.7-0.70.7-0.8
Reaction time trials completed0.31.12.5-0.8-0.5-0.8-0.6-0.7-0.8-1.11.41.6-1.31.2
Reaction time trials AUC0.20.82.1-0.7-0.5-0.7-0.5-0.6-0.7-0.91.31.4-1.11.0
Run reversals in cocaine runway, females2.73.05.31.51.11.51.21.41.51.9-2.3-2.22.0-2.1
Run reversals in cocaine runway, males0.00.00.00.20.20.10.20.20.10.1-0.2-0.2-0.10.0
Latency to leave start box in cocaine runway4.76.47.22.72.42.52.52.52.52.5-2.7-2.72.5-2.4
Latency to leave start box in cocaine runway, F5.97.49.32.82.42.62.52.62.62.8-3.0-3.02.8-2.6
Latency to leave start box in cocaine runway, M0.20.20.30.50.60.40.50.50.50.3-0.2-0.30.2-0.2
Std. dev. time between licks in bursts0.10.20.5-0.2-0.6-0.1-0.5-0.3-0.10.4-0.7-0.60.7-0.7
Total sessions with >9 infusions2.43.04.3-1.9-2.0-2.1-2.0-2.0-1.9-1.71.11.1-1.41.6
Short access day 1 total inactive lever presses0.00.10.3-0.1-0.2-0.4-0.2-0.2-0.2-0.2-0.4-0.5-0.00.3
Short access day 10 total inactive lever presses0.10.50.80.80.90.90.90.80.80.7-0.4-0.40.6-0.6
Short access day 1 total infusions1.83.55.4-2.2-2.3-2.2-2.3-2.2-2.1-1.71.01.1-1.31.5
Short access day 10 total infusions1.32.13.0-1.7-1.7-1.7-1.7-1.7-1.6-1.40.91.0-1.11.3
Short access total infusions2.43.54.8-2.0-2.1-2.2-2.1-2.1-2.0-1.91.11.2-1.51.8
Short access day 1 locomotion2.54.25.2-2.1-2.1-2.3-2.1-2.1-2.1-2.11.71.7-2.12.1
Short access day 10 total locomotion0.41.82.3-1.5-1.5-1.3-1.4-1.4-1.4-1.21.31.3-1.21.0
Short access total locomotion0.91.31.8-1.2-1.1-1.2-1.1-1.1-1.1-1.21.01.0-1.31.2
One hour access (0.3 mA shock)1.72.02.3-1.5-1.5-1.5-1.5-1.5-1.4-1.41.21.3-1.31.3
Compulsive drug intake0.10.20.60.30.60.30.50.30.2-0.20.60.8-0.30.4
One hour access (shock baseline)1.13.03.8-1.9-2.0-1.9-1.9-1.9-1.8-1.61.41.4-1.61.5
Social response proportion0.70.91.20.90.81.00.80.90.91.0-1.0-1.11.1-1.0
Social responses1.21.62.61.10.81.10.91.01.11.3-1.5-1.61.5-1.4
Social time1.42.23.41.81.81.71.81.71.61.2-1.2-1.20.9-1.0
Soleus weight1.13.35.11.51.11.71.21.41.62.0-2.3-2.22.2-2.3
Bone: stiffness0.71.21.41.21.01.11.11.11.11.1-1.1-1.11.1-1.1
Tibialis anterior weight0.10.20.60.20.00.30.10.20.30.5-0.8-0.70.7-0.7
Time to tail flick, vehicle, before self-admin0.30.40.6-0.6-0.5-0.5-0.5-0.6-0.6-0.60.70.7-0.80.6
Time to tail flick, vehicle, after self-admin1.02.02.9-1.5-1.5-1.7-1.5-1.5-1.5-1.41.01.0-1.21.4
Time to tail flick, test, before self-admin0.10.10.2-0.3-0.5-0.2-0.4-0.3-0.20.0-0.4-0.30.0-0.2
Time to tail flick, test, after self-admin0.10.10.40.1-0.20.1-0.1-0.00.10.4-0.5-0.60.7-0.5
Delta time to tail flick, vehicle, before/after SA0.60.61.2-0.8-0.9-1.1-0.9-0.9-0.9-0.80.30.3-0.60.8
Delta time to tail flick, test, before/after SA0.30.40.60.70.70.60.70.60.60.5-0.3-0.50.7-0.5
Tibia length2.67.37.8-2.8-2.5-2.7-2.6-2.6-2.7-2.72.82.7-2.72.7
Ambulatory time before self-admin0.30.81.31.11.11.01.11.11.00.8-0.6-0.50.8-0.7
Ambulatory time after self-admin0.71.02.1-0.6-0.3-0.8-0.4-0.6-0.7-1.21.41.4-1.51.5
Bone: tissue strength0.20.20.40.10.3-0.00.20.1-0.0-0.40.60.6-0.60.6
Total heroin consumption0.10.10.2-0.2-0.2-0.3-0.2-0.2-0.3-0.30.30.4-0.40.4
Bone: trabecular number0.40.71.41.11.21.01.11.00.90.6-0.3-0.30.3-0.4
Bone: trabecular spacing0.91.41.7-1.3-1.3-1.3-1.3-1.3-1.2-1.21.01.0-1.01.1
Bone: trabecular thickness0.60.81.01.01.01.01.01.01.00.9-0.8-0.80.8-0.9
Bone: trabecular tissue density2.44.34.92.11.92.11.92.02.02.2-2.1-2.12.1-2.2
Water consumed over 24 hours0.20.30.50.70.70.70.70.60.60.5-0.3-0.40.4-0.4
Number of responses in last shaping day0.81.01.60.90.71.00.80.90.91.1-1.2-1.21.2-1.1