Hub : Genes

Ucp2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 PL gene expression Ucp2 0.09 0.07 2.8e-08 0.06 0.07 0.08 0.08 1.1e-06 3.5e-08 2.9e-09 2.1e-09
2 Eye gene expression Ucp2 0.72 0.15 1.9e-07 0.08 0.18 0.09 0.13 2.2e-02 1.1e-03 1.8e-02 5.6e-03
3 BLA gene expression Ucp2 0.37 0.17 5.0e-16 0.26 0.26 0.26 0.27 5.4e-14 9.3e-14 2.4e-14 1.3e-14
4 NAcc gene expression Ucp2 0.07 0.04 3.0e-11 0.04 0.07 0.07 0.07 2.5e-07 1.9e-11 1.2e-10 1.4e-10
5 LHb gene expression Ucp2 0.17 0.12 6.5e-03 -0.01 0.01 0 -0.01 4.9e-01 1.9e-01 3.0e-01 5.8e-01
6 IC gene expression Ucp2 0.33 0.13 7.0e-14 0.17 0.25 0.24 0.22 8.3e-08 6.6e-11 1.6e-10 8.5e-10
7 Brain gene expression Ucp2 0.47 0.19 0.0e+00 0.43 0.43 0.43 0.43 3.9e-43 1.2e-43 3.7e-43 2.5e-43
8 OFC mRNA stability Ucp2 0.18 0.12 1.8e-03 0.05 0.03 -0.01 0.03 2.9e-02 5.8e-02 6.5e-01 5.4e-02
9 Adipose gene expression Ucp2 0.12 0.07 3.8e-13 0.11 0.11 0.1 0.1 5.2e-12 9.1e-12 2.1e-11 3.0e-11
10 pVTA gene expression Ucp2 0.17 0.09 4.7e-14 0.08 0.16 0.16 0.16 3.9e-07 1.0e-12 1.7e-12 8.4e-13
11 Liver gene expression Ucp2 0.04 0.03 1.1e-04 0.03 0.03 0.03 0.03 1.5e-04 8.4e-04 2.6e-04 5.4e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11
Bone: apparent density0.00.10.10.30.40.30.30.30.20.0-0.2-0.2-0.2-0.1
Area under the delay curve0.10.10.20.10.20.40.20.30.30.30.30.30.30.4
BMI with tail0.31.12.40.60.30.80.40.60.71.21.51.51.41.4
BMI without tail0.20.61.6-0.0-0.40.1-0.3-0.00.10.71.31.21.11.0
Body weight0.31.53.60.60.10.70.30.50.71.41.81.91.71.8
Weight adjusted by age0.00.00.2-0.2-0.20.1-0.1-0.10.00.20.20.40.20.4
Bone surface0.40.81.1-1.0-1.0-0.9-1.0-1.0-1.0-0.8-0.7-0.7-0.7-0.7
Bone volume0.20.40.5-0.7-0.7-0.5-0.7-0.6-0.6-0.6-0.5-0.5-0.5-0.5
Breakpoint value in progressive ratio session0.30.30.80.70.90.70.90.70.60.30.30.10.20.2
Number of licking bursts4.87.89.22.92.93.02.92.92.92.82.62.62.62.7
Context. condit. distance diff. score3.54.24.9-2.1-2.0-2.2-2.0-2.1-2.1-2.1-1.9-2.0-2.0-2.0
Locomotion velocity, session 10.10.10.20.00.20.00.20.1-0.0-0.3-0.5-0.4-0.4-0.4
Locomotion distance, session 11.41.82.0-1.4-1.2-1.4-1.2-1.3-1.3-1.4-1.4-1.4-1.4-1.3
Locomotion velocity, session 20.00.00.1-0.2-0.3-0.2-0.2-0.2-0.2-0.1-0.1-0.1-0.1-0.1
Locomotion distance, session 20.70.91.1-1.0-0.9-1.0-0.9-0.9-1.0-0.9-1.0-0.9-0.9-0.9
Locomotion velocity, session 31.41.61.9-1.2-1.1-1.2-1.1-1.2-1.2-1.3-1.4-1.4-1.4-1.3
Locomotion distance, session 32.42.63.2-1.6-1.4-1.6-1.4-1.5-1.6-1.7-1.8-1.8-1.8-1.7
Stereotopy head waving bouts, day 30.91.01.21.00.81.00.90.91.01.01.11.11.11.1
Stereotopy head waving duration, day 30.20.20.2-0.5-0.4-0.5-0.4-0.4-0.5-0.5-0.5-0.5-0.5-0.5
Locomotion velocity, session 70.10.10.20.30.40.30.40.30.30.10.10.00.0-0.0
Locomotion distance, session 70.20.20.20.50.50.50.50.50.50.40.40.40.40.4
Stereotopy head waving bouts, day 73.94.45.0-2.2-2.1-2.2-2.1-2.1-2.1-2.1-2.0-2.0-2.0-2.0
Stereotopy head waving duration, day 73.74.55.4-2.3-2.2-2.3-2.2-2.2-2.2-2.1-1.9-1.9-1.9-1.9
Locomotion velocity, session 81.01.21.4-1.2-1.1-1.2-1.1-1.1-1.1-1.1-1.0-1.0-1.0-1.0
Locomotion distance, session 83.14.55.6-2.3-2.2-2.4-2.2-2.2-2.2-2.1-1.9-1.9-1.9-1.9
Degree of sensitization distance2.52.53.61.51.11.51.21.31.41.71.91.91.91.8
Degree of sensitization stereotypy7.68.29.6-3.1-2.9-3.1-2.9-3.0-2.9-2.8-2.7-2.7-2.7-2.7
Conditioned locomotion0.00.00.1-0.00.1-0.10.1-0.0-0.1-0.2-0.3-0.4-0.4-0.3
Cocaine response after cond. corrected2.83.33.71.91.71.91.81.81.81.81.91.81.81.8
Cocaine response after cond. not corrected0.60.81.00.90.80.90.80.90.90.91.00.80.80.8
Cocaine response before conditioning3.54.14.4-2.1-1.9-2.1-1.9-2.0-2.0-2.1-2.0-2.1-2.1-2.1
Saline control response1.01.32.2-1.3-1.5-1.4-1.4-1.3-1.3-1.0-0.8-0.8-0.8-0.8
Bone: connectivity density0.10.20.4-0.2-0.1-0.2-0.1-0.2-0.3-0.5-0.7-0.7-0.7-0.6
Bone: cortical apparent density2.43.34.02.01.92.01.91.91.91.81.61.61.61.7
Bone: cortical area0.00.00.1-0.2-0.3-0.1-0.2-0.1-0.10.10.20.20.20.2
Bone: cortical porosity1.31.41.7-1.1-1.0-1.2-1.0-1.1-1.1-1.3-1.2-1.2-1.2-1.3
Bone: cortical porosity1.51.61.9-1.2-1.1-1.3-1.1-1.2-1.2-1.4-1.3-1.3-1.3-1.4
Bone: cortical thickness0.20.40.60.70.80.70.70.70.70.50.40.40.40.5
Bone: cortical thickness0.20.20.3-0.5-0.4-0.5-0.4-0.5-0.5-0.5-0.5-0.5-0.5-0.5
Bone: cortical tissue density2.33.13.71.91.91.91.91.91.81.71.51.51.51.6
Condit. Reinf. active minus inactive responses0.00.00.1-0.1-0.2-0.0-0.2-0.1-0.00.20.30.30.30.3
Condit. Reinf. active-inactive response ratio0.10.10.3-0.3-0.5-0.3-0.5-0.4-0.3-0.00.10.10.10.2
Condit. Reinf. active responses0.00.10.10.10.10.20.10.10.20.30.30.30.30.3
Condit. Reinf. inactive responses0.00.00.00.10.20.10.10.10.10.0-0.0-0.0-0.0-0.0
Incentive salience index mean0.00.00.1-0.2-0.3-0.2-0.3-0.2-0.20.00.10.10.10.1
Condit. Reinf. lever presses0.10.10.2-0.5-0.5-0.4-0.5-0.4-0.4-0.3-0.3-0.3-0.3-0.2
Condit. Reinf. active minus inactive responses4.55.89.3-2.9-3.0-2.7-3.0-2.8-2.6-2.0-1.8-1.7-1.7-1.7
Condit. Reinf. active-inactive response ratio1.21.31.9-1.4-1.4-1.3-1.4-1.3-1.2-1.0-0.9-0.9-0.9-0.9
Condit. Reinf. active responses5.47.512.7-3.3-3.6-3.1-3.4-3.2-3.0-2.3-2.0-1.8-1.8-1.8
Condit. Reinf. inactive responses2.63.36.1-2.2-2.5-2.1-2.4-2.2-2.0-1.5-1.2-1.1-1.1-1.1
Condit. Reinf. lever presses13.719.027.2-5.0-5.2-4.8-5.1-4.9-4.7-3.9-3.5-3.4-3.3-3.3
Condit. Reinf. lever reinforcers received6.59.114.8-3.6-3.8-3.4-3.7-3.5-3.3-2.5-2.2-2.1-2.0-2.0
Conditioned reinforcement - actives1.93.23.6-1.9-1.8-1.9-1.8-1.8-1.8-1.8-1.6-1.7-1.7-1.8
Conditioned reinforcement - inactives0.10.10.20.40.40.30.40.30.30.20.40.30.20.1
Conditioned locomotion4.96.48.0-2.5-2.2-2.5-2.3-2.4-2.4-2.6-2.6-2.7-2.8-2.7
Patch foraging indifference point 0 sec3.25.97.4-2.7-2.7-2.6-2.7-2.6-2.6-2.3-2.2-2.1-2.0-2.1
Patch foraging indifference point AUC0.20.30.80.30.10.40.20.30.40.60.70.90.80.7
Delay disc. indifference point, 0s delay0.80.91.3-1.1-1.1-1.0-1.1-1.0-1.0-0.8-0.7-0.7-0.7-0.6
Delay disc. indifference point, 16s delay0.00.00.10.10.20.30.20.20.20.10.00.00.10.1
Delay disc. indifference point, 2s delay0.10.10.4-0.5-0.6-0.3-0.6-0.5-0.4-0.10.0-0.00.00.1
Delay disc. indifference point, 24s delay0.91.01.61.01.21.31.21.11.00.90.70.70.80.8
Delay disc. indifference point, 4s delay0.20.20.5-0.6-0.7-0.3-0.6-0.5-0.4-0.00.10.10.20.2
Delay disc. indifference point, 8s delay0.00.00.0-0.10.10.10.10.10.10.10.10.10.10.2
Indifference point function ln k2.23.95.4-1.9-1.6-1.9-1.7-1.8-1.9-2.1-2.2-2.3-2.1-2.1
Indifference point function log k2.23.95.4-1.9-1.6-1.9-1.7-1.8-1.9-2.1-2.2-2.3-2.1-2.1
Patch foraging total patch changes 0 sec2.44.55.8-2.4-2.4-2.3-2.4-2.3-2.3-2.0-1.9-1.8-1.7-1.8
Patch foraging total patch changes 12 sec0.20.20.7-0.6-0.8-0.5-0.7-0.6-0.5-0.1-0.10.10.20.1
Patch foraging total patch changes 18 sec1.21.93.1-1.6-1.8-1.6-1.7-1.6-1.5-1.2-0.9-0.7-0.9-1.0
Patch foraging total patch changes 24 sec0.10.20.7-0.6-0.8-0.5-0.8-0.6-0.5-0.20.10.10.1-0.0
Patch foraging total patch changes 6 sec0.60.91.1-1.1-1.0-0.9-1.0-1.0-1.0-0.8-1.0-0.8-0.6-0.8
Patch foraging time to switch 0 sec2.04.25.92.42.42.22.42.32.21.81.61.71.51.5
Patch foraging water rate 0 sec2.34.96.5-2.5-2.5-2.3-2.4-2.4-2.3-2.1-1.9-1.9-1.8-1.9
Patch foraging water rate 12 sec2.04.14.8-2.2-2.1-2.1-2.1-2.1-2.1-2.0-1.8-1.9-1.9-2.0
Patch foraging water rate 18 sec0.81.31.9-1.3-1.4-1.3-1.3-1.3-1.2-1.0-0.7-1.0-0.9-0.8
Patch foraging water rate 24 sec2.23.14.0-1.8-1.5-1.7-1.6-1.7-1.7-1.8-2.0-1.9-1.8-1.8
Patch foraging water rate 6 sec1.52.22.4-1.5-1.4-1.6-1.5-1.5-1.5-1.5-1.5-1.4-1.5-1.5
Seeking ratio, delayed vs. immediate footshock0.60.71.31.11.10.71.11.00.90.60.80.60.30.4
Distance traveled before self-admin0.91.21.51.21.21.21.21.21.21.11.00.91.11.0
Distance traveled after self-admin0.20.20.50.20.4-0.10.30.20.0-0.4-0.7-0.6-0.7-0.6
Extensor digitorum longus weight0.51.82.81.20.91.21.01.11.21.51.71.61.61.6
Bone: elastic displacement1.11.32.41.41.51.31.51.41.30.90.70.70.70.6
Bone: elastic work0.91.12.31.31.51.21.41.31.20.80.60.60.60.5
Bone: endosteal estimation0.30.61.7-1.0-1.3-0.8-1.2-1.0-0.9-0.3-0.0-0.0-0.0-0.1
Bone: endosteal perimeter0.51.12.6-1.3-1.6-1.1-1.5-1.3-1.2-0.6-0.3-0.3-0.3-0.4
Epididymis fat weight0.51.62.11.31.21.31.21.21.21.31.41.41.31.1
Delta time in closed arm before/after self-admin4.44.15.51.91.61.91.71.81.92.12.32.32.32.2
Delta time in open arm before/after self-admin2.12.13.1-1.6-1.7-1.7-1.7-1.6-1.6-1.3-0.9-1.0-1.2-1.2
Diff in mean of infusions in LGA sessions4.75.77.12.62.72.52.62.62.52.22.22.12.12.0
Delay discount exponential model param0.10.10.2-0.1-0.2-0.5-0.3-0.3-0.3-0.4-0.3-0.3-0.4-0.4
Extinction: sum of active levers before priming0.00.00.1-0.0-0.1-0.0-0.0-0.00.00.10.30.20.00.2
Active lever presses in extinction session 65.55.48.4-2.1-1.7-2.2-1.8-2.0-2.1-2.4-2.9-2.9-2.7-2.6
Bone: final force0.10.10.20.40.40.40.40.40.30.30.30.30.30.3
Bone: final moment0.00.00.00.20.20.20.20.20.20.20.20.20.20.2
Food consumed during 24 hour testing period4.35.96.7-2.6-2.5-2.6-2.5-2.5-2.5-2.4-2.4-2.3-2.3-2.3
Glucose0.00.00.10.20.20.20.20.20.20.20.10.20.20.2
Heart weight1.01.51.9-1.4-1.3-1.4-1.3-1.3-1.3-1.2-1.1-1.1-1.1-1.1
Delay discount hyperbolic model param0.10.10.3-0.1-0.2-0.4-0.2-0.3-0.3-0.4-0.4-0.4-0.4-0.5
Intermittent access intake day 1-15 change0.61.11.8-1.1-0.9-1.0-1.0-1.0-1.0-1.0-1.3-1.3-1.1-0.9
Intermittent access intake escalation0.71.52.2-1.3-1.1-1.2-1.1-1.2-1.2-1.2-1.5-1.4-1.2-1.1
Intermittent access intake escalation 20.80.91.3-1.0-0.9-0.9-0.9-0.9-0.9-0.8-1.2-1.1-0.7-0.7
Intermitt. access day 1 inactive lever presses0.52.12.51.61.41.51.51.51.51.41.51.41.21.3
Intermitt. access day 15 inactive lever presses0.10.20.50.60.70.60.70.60.50.20.20.20.0-0.0
Intermitt. access escalation Index0.00.00.1-0.2-0.2-0.1-0.2-0.2-0.2-0.1-0.3-0.2-0.2-0.0
Intermittent access day 1 total infusions1.62.53.3-1.7-1.7-1.8-1.7-1.7-1.7-1.6-1.1-1.1-1.6-1.7
Intermittent access day 15 total infusions2.23.33.7-1.9-1.8-1.9-1.8-1.8-1.8-1.8-1.7-1.7-1.8-1.8
Intermittent access terminal intake (last 3 days)2.83.64.2-2.1-1.9-2.0-2.0-2.0-2.0-1.9-1.8-1.8-1.9-1.8
Intermittent access total infusions2.22.63.3-1.7-1.8-1.8-1.8-1.7-1.7-1.6-1.1-1.2-1.5-1.5
Intermittent access day 1 locomotion0.60.71.2-0.8-0.7-0.9-0.7-0.8-0.8-0.9-0.8-0.7-1.1-1.1
Intermittent access day 15 total locomotion1.52.73.4-1.6-1.4-1.7-1.5-1.5-1.6-1.7-1.8-1.7-1.8-1.8
Intermittent access total locomotion1.41.72.2-1.3-1.2-1.4-1.3-1.3-1.3-1.4-1.1-1.1-1.5-1.4
Intermittent access standard deviation0.00.00.2-0.1-0.10.1-0.1-0.0-0.00.20.10.10.40.4
Left kidney weight0.10.51.20.1-0.10.3-0.00.20.30.80.91.01.11.1
Right kidney weight0.10.61.40.1-0.30.2-0.10.10.30.81.01.21.21.2
Cocaine induced anxiety1.31.82.61.51.61.61.61.51.41.21.00.91.21.1
Post-drug Anxiety2.42.63.21.81.81.81.81.71.71.51.41.31.51.4
Baseline Anxiety0.10.10.2-0.3-0.4-0.4-0.4-0.4-0.3-0.20.00.0-0.2-0.1
Tail length0.20.82.0-0.0-0.50.1-0.3-0.10.20.91.31.31.41.3
Length with tail0.10.61.50.1-0.40.1-0.2-0.00.20.81.11.21.11.1
Length without tail0.10.40.60.60.60.60.60.60.60.60.60.80.60.6
Times rat made contact with spout0.91.01.40.90.81.00.80.90.91.11.21.11.11.2
Lifetime Intake2.63.24.3-1.9-2.0-2.1-2.0-2.0-1.9-1.8-1.2-1.3-1.6-1.7
Liver weight, left0.61.01.70.80.50.90.60.70.81.11.31.21.31.2
Liver weight, right2.34.15.61.91.51.91.61.81.92.22.22.42.42.2
Locomotor activity0.71.11.5-1.2-1.0-1.0-1.0-1.0-1.0-1.0-1.2-1.2-0.9-0.9
Locomotor testing distance0.91.62.6-1.6-1.6-1.4-1.5-1.4-1.4-1.1-1.1-1.0-0.8-0.9
Locomotor testing rearing0.10.10.3-0.5-0.6-0.2-0.5-0.4-0.30.10.10.20.30.3
Locomotion in novel chamber1.51.93.9-1.3-1.0-1.2-1.1-1.1-1.2-1.3-1.8-2.0-1.3-1.4
Locomotion in novel chamber post-restriction2.33.84.5-2.0-1.9-2.1-1.9-2.0-1.9-1.9-1.9-1.9-1.8-2.0
Fecal boli incidents, locomotor time 11.21.72.4-1.2-1.1-1.3-1.1-1.2-1.2-1.3-1.5-1.5-1.5-1.4
Change in fecal boli incidents, locomotor task1.01.01.21.11.01.01.01.01.01.01.01.01.00.9
Time >=10cm from walls, locomotor time 13.03.23.6-1.9-1.7-1.8-1.8-1.8-1.8-1.8-1.8-1.8-1.8-1.8
Bouts of movement, locomotor time 10.30.30.4-0.5-0.5-0.5-0.6-0.6-0.6-0.5-0.6-0.6-0.6-0.5
Total resting periods, locomotor time 10.40.50.8-0.5-0.5-0.6-0.5-0.6-0.6-0.8-0.9-0.8-0.9-0.8
Rest time, locomotor task time 10.10.20.5-0.1-0.1-0.4-0.1-0.2-0.3-0.5-0.6-0.5-0.6-0.7
Distance moved, locomotor task time 10.20.30.80.20.10.60.20.30.40.70.70.70.70.9
Vertical activity count, locomotor time 10.00.10.2-0.3-0.3-0.1-0.2-0.2-0.10.20.40.30.40.3
Time >=10cm from walls, locomotor time 20.91.32.0-1.4-1.4-1.3-1.4-1.3-1.3-1.1-0.8-0.8-0.8-0.9
Bouts of movement, locomotor time 20.00.10.2-0.1-0.30.1-0.2-0.1-0.00.30.30.30.30.5
Total resting periods, locomotor time 20.10.20.40.20.00.30.10.20.30.50.50.50.60.6
Rest time, locomotor task time 22.32.93.92.02.01.71.91.81.81.51.51.61.51.2
Distance moved, locomotor task time 21.92.33.6-1.9-1.9-1.6-1.8-1.7-1.7-1.3-1.2-1.2-1.1-1.0
Vertical activity count, locomotor time 20.40.51.1-1.0-1.1-0.8-1.0-0.9-0.8-0.5-0.3-0.3-0.3-0.3
Light reinforcement 11.84.45.22.32.32.32.32.22.22.02.02.01.91.7
Light reinforcement 20.00.10.20.40.40.30.40.30.30.10.1-0.0-0.1-0.1
Bone: marrow area0.20.41.3-0.8-1.1-0.6-1.0-0.8-0.7-0.20.10.10.10.1
Bone: maximum diameter0.51.02.1-1.3-1.5-1.1-1.4-1.2-1.1-0.7-0.5-0.5-0.5-0.5
Bone: maximum force0.00.00.00.20.20.20.20.20.20.10.10.10.10.1
Bone: maximum moment0.00.00.00.0-0.0-0.0-0.0-0.0-0.0-0.00.00.00.00.0
Mean time between licks in bursts0.61.43.5-1.5-1.9-1.4-1.7-1.5-1.3-0.6-0.1-0.2-0.2-0.2
Mean num. licks in bursts3.86.06.9-2.6-2.6-2.6-2.6-2.5-2.5-2.4-2.3-2.2-2.2-2.3
Cd content in liver0.90.91.21.00.80.90.80.90.91.01.11.11.11.1
Co content in liver0.40.51.1-0.9-1.1-0.8-1.0-0.9-0.8-0.5-0.2-0.3-0.3-0.3
Cu content in liver0.20.30.70.1-0.20.1-0.10.00.10.50.80.80.80.8
Fe content in liver0.00.00.10.20.20.10.20.20.20.20.20.20.20.2
K content in liver0.40.40.60.60.50.60.50.60.60.70.70.80.80.8
Mg content in liver0.10.10.1-0.3-0.3-0.3-0.3-0.3-0.3-0.2-0.1-0.1-0.1-0.1
Mn content in liver0.20.20.70.60.80.60.70.60.50.2-0.0-0.0-0.0-0.0
Na content in liver0.50.60.7-0.9-0.8-0.8-0.8-0.8-0.8-0.7-0.6-0.6-0.6-0.6
Rb content in liver0.30.30.4-0.6-0.7-0.7-0.6-0.6-0.6-0.5-0.4-0.4-0.4-0.4
Se content in liver3.03.65.62.22.42.12.32.22.11.61.41.41.41.4
Sr content in liver0.40.30.4-0.5-0.4-0.5-0.4-0.5-0.5-0.6-0.6-0.6-0.6-0.6
Zn content in liver1.51.73.0-1.6-1.7-1.5-1.7-1.5-1.4-1.1-0.8-0.8-0.8-0.8
Bone: minimum diameter0.20.41.00.2-0.20.3-0.10.10.30.81.01.01.01.0
Time in familiar zone, hab. session 10.10.10.20.30.10.20.20.20.30.40.50.50.50.4
Time in novel zone, hab. session 10.30.30.30.60.60.60.60.60.50.50.40.40.40.4
Total zone transitions, hab. session 10.20.30.5-0.4-0.2-0.5-0.3-0.4-0.4-0.6-0.7-0.7-0.7-0.7
Total locomotion distance, hab. session 11.82.63.31.51.31.51.31.41.51.71.81.81.81.8
Locomotion velocity, hab. session 11.01.41.91.10.91.11.01.11.11.31.31.31.31.4
Time in familiar zone, hab. session 21.11.21.9-1.3-1.4-1.3-1.3-1.3-1.2-1.0-0.7-0.8-0.8-0.7
Time in novel zone, hab. session 20.20.20.40.50.60.60.60.50.50.30.10.10.10.1
Total zone transitions, hab. session 22.22.83.1-1.7-1.5-1.7-1.6-1.6-1.7-1.7-1.7-1.7-1.7-1.7
Total locomotion distance, hab. session 20.40.61.10.50.30.50.30.50.60.91.01.11.11.0
Locomotion velocity, hab. session 20.71.01.70.70.50.80.60.70.81.11.31.31.31.3
Novel to familiar place preference ratio0.10.10.1-0.3-0.3-0.3-0.3-0.3-0.3-0.3-0.2-0.3-0.3-0.3
Novelty place preference0.10.10.1-0.3-0.3-0.3-0.3-0.3-0.3-0.3-0.2-0.3-0.3-0.3
Time in novel zone, NPP test0.20.20.3-0.5-0.5-0.5-0.5-0.5-0.5-0.5-0.5-0.5-0.5-0.5
Total zone transitions, NPP test0.40.60.9-0.7-0.6-0.8-0.6-0.7-0.7-0.8-0.9-0.9-0.9-0.9
Total locomotion distance, NPP test1.11.52.01.10.91.21.01.11.21.41.41.41.41.4
Locomotion velocity, NPP test1.62.32.81.51.31.51.31.41.51.61.61.71.71.7
Intraocular pressure0.40.61.1-0.7-0.5-0.6-0.5-0.6-0.6-0.8-1.1-0.9-0.9-0.9
Delta distance traveled before/after self-admin3.33.44.4-1.7-1.6-1.9-1.7-1.7-1.8-1.9-2.0-1.9-2.1-2.0
Delta ambulatory time before/after self-admin2.93.54.9-1.7-1.6-1.9-1.7-1.8-1.8-2.0-2.0-1.9-2.2-2.1
Parametrial fat weight0.92.22.51.61.41.51.41.51.51.41.61.61.51.3
Pavlov. Cond. lever latency1.21.52.11.41.51.41.41.41.31.11.01.01.01.0
Pavlov. Cond. magazine entry latency2.63.44.9-2.1-2.2-2.1-2.2-2.1-2.0-1.7-1.4-1.4-1.4-1.4
Pavlov. Cond. change in total contacts1.21.31.8-1.3-1.4-1.3-1.3-1.3-1.2-1.0-0.8-0.8-0.8-0.8
Pavlov. Cond. index score2.22.84.1-2.0-2.0-1.9-2.0-1.9-1.8-1.5-1.3-1.3-1.3-1.3
Pavlov. Cond. latency score2.22.84.0-1.9-2.0-1.9-2.0-1.9-1.8-1.5-1.3-1.3-1.3-1.3
Pavlov. Cond. lever contacts1.01.11.7-1.3-1.3-1.2-1.3-1.2-1.2-0.9-0.8-0.8-0.8-0.8
Pavlov. Cond. magazine entry number2.83.65.12.22.32.12.22.12.01.71.51.51.51.5
Pavlov. Cond. intertrial magazine entries0.70.81.21.11.11.01.11.01.00.80.70.60.60.7
Pavlov. Cond. lever-magazine prob. diff.1.82.33.3-1.8-1.8-1.7-1.8-1.7-1.6-1.4-1.1-1.1-1.1-1.1
Pavlov. Cond. response bias1.21.52.2-1.4-1.5-1.4-1.5-1.4-1.3-1.1-0.9-0.9-0.9-0.9
Pavlov. Cond. lever latency16.222.029.95.35.55.25.45.25.04.33.93.83.73.7
Pavlov. Cond. magazine entry latency5.06.07.1-2.7-2.6-2.7-2.6-2.6-2.6-2.4-2.3-2.2-2.2-2.2
Pavlov. Cond. change in total contacts10.817.322.9-4.7-4.8-4.6-4.7-4.6-4.4-3.9-3.6-3.4-3.4-3.4
Pavlov. Cond. index score12.516.822.3-4.6-4.7-4.5-4.6-4.5-4.4-3.8-3.5-3.3-3.3-3.3
Pavlov. Cond. latency score11.315.019.7-4.4-4.4-4.3-4.4-4.2-4.1-3.6-3.3-3.2-3.2-3.2
Pavlov. Cond. lever contacts14.920.628.2-5.2-5.3-5.0-5.2-5.0-4.8-4.2-3.8-3.6-3.6-3.6
Pavlov. Cond. magazine entry number8.410.312.33.53.53.53.53.43.33.13.02.82.82.8
Pavlov. Cond. intertrial magazine entries0.40.51.20.40.20.50.30.40.50.81.11.01.01.0
Pavlov. Cond. lever-magazine prob. diff.11.315.120.5-4.4-4.5-4.3-4.4-4.3-4.1-3.6-3.2-3.1-3.1-3.1
Pavlov. Cond. response bias16.322.229.5-5.3-5.4-5.2-5.3-5.2-5.0-4.4-4.0-3.8-3.8-3.8
Time in closed arm before self-admin3.54.56.1-2.1-1.8-2.1-1.9-1.9-2.0-2.2-2.5-2.4-2.1-2.2
Time in closed arm after self-admin0.20.20.60.60.80.50.70.60.50.3-0.00.10.20.1
Time in open arm before self-admin4.34.75.72.32.32.42.32.32.22.12.01.82.02.1
Time in open arm after self-admin0.20.20.50.2-0.00.20.00.10.20.50.70.60.50.6
Bone: periosteal estimation0.20.41.1-0.8-1.1-0.6-1.0-0.8-0.7-0.20.00.00.0-0.0
Bone: periosteal perimeter0.30.41.2-0.9-1.1-0.7-1.0-0.9-0.7-0.3-0.1-0.1-0.1-0.1
Bone: post-yield work0.00.00.0-0.2-0.2-0.1-0.2-0.1-0.1-0.1-0.0-0.0-0.0-0.0
Progressive ratio test 1 active lever presses0.10.10.4-0.2-0.2-0.4-0.2-0.3-0.3-0.5-0.2-0.2-0.5-0.6
Progressive ratio test 1 breakpoint0.10.10.3-0.2-0.1-0.3-0.2-0.2-0.3-0.4-0.2-0.2-0.4-0.6
Progressive ratio test 1 inactive lever presses0.00.10.3-0.1-0.0-0.3-0.1-0.1-0.2-0.30.30.2-0.3-0.5
Progressive ratio test 2 active lever presses0.40.40.6-0.8-0.8-0.7-0.8-0.8-0.7-0.6-0.4-0.4-0.5-0.6
Progressive ratio test 2 breakpoint0.40.50.7-0.8-0.8-0.8-0.8-0.8-0.8-0.7-0.4-0.4-0.5-0.6
Progressive ratio test 2 inactive lever presses0.40.71.1-0.9-0.8-0.9-0.8-0.8-0.9-0.9-0.6-0.6-0.9-1.1
Incentive Sensitization - Responses0.50.61.1-1.1-1.0-0.9-1.0-0.9-0.9-0.7-0.6-0.6-0.4-0.5
Incentive Sensitization - Breakpoint0.50.71.1-1.1-1.0-0.9-1.0-0.9-0.9-0.7-0.7-0.7-0.5-0.5
Sum of active levers in priming session hrs 5-60.10.10.2-0.10.0-0.0-0.0-0.1-0.1-0.3-0.2-0.5-0.4-0.3
Progressive ratio0.50.81.1-0.9-0.8-1.0-0.8-0.8-0.9-0.9-0.9-1.0-1.1-1.0
Food seeking constrained by brief footshock0.40.41.0-0.9-1.0-0.7-0.9-0.8-0.7-0.4-0.3-0.4-0.3-0.2
Seeking ratio, punishment vs. effort0.20.30.70.0-0.20.2-0.10.00.20.50.70.80.80.7
Retroperitoneal fat weight4.017.221.43.93.54.13.63.83.94.34.64.64.64.4
Reaction time number correct0.51.02.4-0.8-0.5-0.8-0.6-0.7-0.8-1.1-1.4-1.6-1.3-1.2
Reaction time mean minus median0.20.50.9-0.8-0.9-0.8-0.9-0.8-0.7-0.5-0.4-0.4-0.5-0.3
Reaction time mean minus median AUC0.61.51.8-1.3-1.3-1.3-1.3-1.3-1.3-1.2-1.1-1.0-1.1-1.0
Reaction time num false alarms2.63.74.11.91.92.01.92.02.02.01.91.81.91.9
Reaction time num false alarms AUC1.11.71.91.31.31.41.31.31.31.31.31.11.31.3
Reaction time trials correct on left0.51.02.4-0.8-0.5-0.8-0.6-0.7-0.8-1.1-1.4-1.6-1.3-1.2
Reaction time trials on left0.61.12.5-0.8-0.5-0.8-0.6-0.7-0.8-1.1-1.4-1.6-1.3-1.2
Reaction time mean1.11.72.01.31.21.31.21.31.31.31.41.31.21.3
Reaction time mean AUC1.11.82.11.41.41.41.41.41.41.31.41.31.21.2
Median of all reaction times1.82.52.81.71.61.61.61.61.61.61.71.51.41.5
Reaction time omissions0.30.40.70.50.50.60.50.60.60.70.80.80.70.8
Reaction time false alarm rate2.33.13.71.71.61.71.61.71.71.81.91.91.91.8
Reaction time premature initiation rate0.20.30.7-0.4-0.8-0.4-0.7-0.5-0.30.20.60.60.40.5
Reaction time premature initiations0.30.61.3-0.9-1.1-0.9-1.1-1.0-0.9-0.6-0.4-0.5-0.4-0.3
Std. dev. reaction times0.10.30.70.1-0.00.30.00.20.30.60.70.70.70.8
Reaction time trials completed0.61.12.5-0.8-0.5-0.8-0.6-0.7-0.8-1.1-1.4-1.6-1.3-1.2
Reaction time trials AUC0.40.82.1-0.7-0.5-0.7-0.5-0.6-0.7-0.9-1.3-1.4-1.1-1.0
Run reversals in cocaine runway, females3.13.05.31.51.11.51.21.41.51.92.32.22.02.1
Run reversals in cocaine runway, males0.00.00.00.20.20.10.20.20.10.10.20.2-0.1-0.0
Latency to leave start box in cocaine runway5.66.47.22.72.42.52.52.52.52.52.72.72.52.4
Latency to leave start box in cocaine runway, F6.47.49.32.82.42.62.52.62.62.83.03.02.82.6
Latency to leave start box in cocaine runway, M0.20.20.30.50.60.40.50.50.50.30.20.30.20.2
Std. dev. time between licks in bursts0.20.20.5-0.2-0.6-0.1-0.5-0.3-0.10.40.70.60.70.7
Total sessions with >9 infusions2.53.04.3-1.9-2.0-2.1-2.0-2.0-1.9-1.7-1.1-1.1-1.4-1.6
Short access day 1 total inactive lever presses0.10.10.3-0.1-0.2-0.4-0.2-0.2-0.2-0.20.40.5-0.0-0.3
Short access day 10 total inactive lever presses0.20.50.80.80.90.90.90.80.80.70.40.40.60.6
Short access day 1 total infusions2.63.55.4-2.2-2.3-2.2-2.3-2.2-2.1-1.7-1.0-1.1-1.3-1.5
Short access day 10 total infusions1.72.13.0-1.7-1.7-1.7-1.7-1.7-1.6-1.4-0.9-1.0-1.1-1.3
Short access total infusions2.73.54.8-2.0-2.1-2.2-2.1-2.1-2.0-1.9-1.1-1.2-1.5-1.8
Short access day 1 locomotion3.44.25.2-2.1-2.1-2.3-2.1-2.1-2.1-2.1-1.7-1.7-2.1-2.1
Short access day 10 total locomotion0.91.82.3-1.5-1.5-1.3-1.4-1.4-1.4-1.2-1.3-1.3-1.2-1.0
Short access total locomotion1.11.31.8-1.2-1.1-1.2-1.1-1.1-1.1-1.2-1.0-1.0-1.3-1.2
One hour access (0.3 mA shock)1.72.02.3-1.5-1.5-1.5-1.5-1.5-1.4-1.4-1.2-1.3-1.3-1.3
Compulsive drug intake0.20.20.60.30.60.30.50.30.2-0.2-0.6-0.8-0.3-0.4
One hour access (shock baseline)2.03.03.8-1.9-2.0-1.9-1.9-1.9-1.8-1.6-1.4-1.4-1.6-1.5
Social response proportion0.80.91.20.90.81.00.80.90.91.01.01.11.11.0
Social responses1.21.52.61.10.81.10.91.01.11.31.51.61.51.4
Social time1.62.23.41.81.81.71.81.71.61.21.21.20.91.0
Soleus weight1.13.35.11.51.11.71.21.41.62.02.32.22.22.3
Bone: stiffness0.81.21.41.21.01.11.11.11.11.11.11.11.11.1
Tibialis anterior weight0.10.20.60.20.00.30.10.20.30.50.80.70.70.7
Time to tail flick, vehicle, before self-admin0.40.40.6-0.6-0.5-0.5-0.5-0.6-0.6-0.6-0.7-0.7-0.8-0.6
Time to tail flick, vehicle, after self-admin1.52.02.9-1.5-1.5-1.7-1.5-1.5-1.5-1.4-1.0-1.0-1.2-1.4
Time to tail flick, test, before self-admin0.10.10.2-0.3-0.5-0.2-0.4-0.3-0.20.00.40.30.00.2
Time to tail flick, test, after self-admin0.10.10.40.1-0.20.1-0.1-0.00.10.40.50.60.70.5
Delta time to tail flick, vehicle, before/after SA0.70.61.2-0.8-0.9-1.1-0.9-0.9-0.9-0.8-0.3-0.3-0.6-0.8
Delta time to tail flick, test, before/after SA0.40.40.60.70.70.60.70.60.60.50.30.50.70.5
Tibia length2.67.37.8-2.8-2.5-2.7-2.6-2.6-2.7-2.7-2.8-2.7-2.7-2.7
Ambulatory time before self-admin0.60.81.31.11.11.01.11.11.00.80.60.50.80.7
Ambulatory time after self-admin0.91.02.1-0.6-0.3-0.8-0.4-0.6-0.7-1.2-1.4-1.4-1.5-1.5
Bone: tissue strength0.20.20.40.10.3-0.00.20.1-0.0-0.4-0.6-0.6-0.6-0.6
Total heroin consumption0.10.10.2-0.2-0.2-0.3-0.2-0.2-0.3-0.3-0.3-0.4-0.4-0.4
Bone: trabecular number0.40.71.41.11.21.01.11.00.90.60.30.30.30.4
Bone: trabecular spacing1.01.41.7-1.3-1.3-1.3-1.3-1.3-1.2-1.2-1.0-1.0-1.0-1.1
Bone: trabecular thickness0.70.81.01.01.01.01.01.01.00.90.80.80.80.9
Bone: trabecular tissue density2.94.34.92.11.92.11.92.02.02.22.12.12.12.2
Water consumed over 24 hours0.20.30.50.70.70.70.70.60.60.50.30.40.40.4
Number of responses in last shaping day0.91.01.60.90.71.00.80.90.91.11.21.21.21.1