Hub : Genes

Ucp2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 PL gene expression Ucp2 0.09 0.07 2.1e-08 0.06 0.07 0.09 0.08 1.0e-06 3.7e-08 9.6e-10 2.1e-09
2 BLA gene expression Ucp2 0.37 0.18 6.1e-16 0.24 0.25 0.27 0.26 2.4e-13 8.8e-14 6.8e-15 2.9e-14
3 OFC gene expression Ucp2 0.22 0.15 6.5e-03 0.01 0 -0.01 -0 2.0e-01 3.3e-01 4.7e-01 3.5e-01
4 Eye gene expression Ucp2 0.74 0.14 2.8e-08 0.16 0.22 0.24 0.22 1.7e-03 2.4e-04 1.3e-04 2.9e-04
5 LHb gene expression Ucp2 0.21 0.14 3.2e-03 -0.01 0.03 0.01 0 9.7e-01 5.9e-02 1.7e-01 3.2e-01
6 pVTA gene expression Ucp2 0.25 0.13 4.6e-09 0.1 0.19 0.18 0.17 6.8e-05 9.5e-09 4.0e-08 9.9e-08
7 NAcc gene expression Ucp2 0.07 0.05 3.4e-08 0.05 0.07 0.05 0.06 3.0e-06 1.3e-08 8.3e-07 1.1e-07
8 Brain gene expression Ucp2 0.47 0.18 0.0e+00 0.43 0.44 0.44 0.44 8.0e-43 3.7e-44 1.8e-44 2.0e-44
9 Adipose gene expression Ucp2 0.12 0.07 4.1e-13 0.11 0.11 0.1 0.1 6.5e-12 8.7e-12 1.6e-11 2.9e-11
10 Liver gene expression Ucp2 0.04 0.03 6.5e-05 0.03 0.03 0.03 0.03 1.0e-04 6.6e-04 2.5e-04 3.5e-04
11 OFC mRNA stability Ucp2 0.17 0.12 1.7e-03 0.04 0.04 0 0.04 4.0e-02 3.9e-02 2.4e-01 4.4e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11
Bone: apparent density0.00.10.2-0.0-0.0-0.4-0.10.10.1-0.00.20.30.3-0.5
Area under the delay curve0.20.20.3-0.3-0.5-0.3-0.40.30.40.4-0.6-0.3-0.50.5
BMI with tail0.00.20.3-0.4-0.4-0.2-0.30.30.30.3-0.4-0.5-0.50.6
BMI without tail0.40.83.3-0.3-0.51.2-0.1-0.00.10.3-1.0-1.2-1.21.8
Body weight0.41.55.4-0.6-0.81.0-0.40.30.40.7-1.3-1.8-1.82.3
Weight adjusted by age0.20.20.90.20.10.90.3-0.3-0.3-0.2-0.2-0.3-0.40.6
Bone surface0.71.21.61.21.21.21.2-1.2-1.2-1.21.20.80.9-0.6
Bone volume0.40.80.90.90.90.90.9-1.0-0.9-0.90.90.70.7-0.6
Breakpoint value in progressive ratio session0.10.10.7-0.1-0.2-0.8-0.30.30.30.20.10.20.2-0.5
Number of licking bursts6.47.59.1-3.0-3.0-2.4-2.92.92.92.9-2.8-2.6-2.62.2
Context. condit. distance diff. score3.54.25.62.22.21.72.0-2.0-2.1-2.12.42.02.0-1.8
Locomotion velocity, session 10.10.10.50.00.0-0.6-0.10.10.1-0.00.40.40.4-0.7
Locomotion distance, session 11.21.61.81.31.30.81.2-1.2-1.2-1.31.31.41.3-1.3
Locomotion velocity, session 20.00.00.10.20.20.30.3-0.2-0.2-0.20.10.10.1-0.0
Locomotion distance, session 20.50.70.91.00.90.60.8-0.9-0.9-0.90.70.90.9-0.8
Locomotion velocity, session 31.21.41.91.31.20.51.1-1.1-1.1-1.21.41.41.3-1.3
Locomotion distance, session 32.32.53.31.71.60.91.4-1.4-1.4-1.61.81.81.7-1.7
Stereotopy head waving bouts, day 30.70.81.1-0.9-0.9-0.4-0.80.80.80.9-1.0-1.0-1.01.0
Stereotopy head waving duration, day 30.10.10.20.40.40.00.3-0.3-0.3-0.40.40.40.5-0.5
Locomotion velocity, session 70.10.10.4-0.3-0.3-0.7-0.40.40.40.30.0-0.1-0.1-0.1
Locomotion distance, session 70.20.20.3-0.5-0.5-0.3-0.50.50.50.5-0.3-0.4-0.40.4
Stereotopy head waving bouts, day 73.23.74.52.12.11.52.0-2.0-2.0-2.01.91.91.9-1.7
Stereotopy head waving duration, day 73.54.25.42.32.21.92.2-2.2-2.2-2.22.01.91.9-1.5
Locomotion velocity, session 81.01.21.41.21.21.11.1-1.1-1.1-1.11.21.01.0-0.9
Locomotion distance, session 82.94.25.12.32.21.92.1-2.1-2.1-2.12.21.91.9-1.6
Degree of sensitization distance2.22.24.2-1.5-1.5-0.2-1.21.21.21.4-1.6-1.9-1.92.1
Degree of sensitization stereotypy7.07.69.53.13.02.32.9-2.9-2.9-2.92.72.72.7-2.3
Conditioned locomotion0.00.00.1-0.00.0-0.4-0.10.10.10.00.20.20.2-0.4
Cocaine response after cond. corrected2.83.13.6-1.9-1.9-1.3-1.81.71.81.8-1.9-1.8-1.81.7
Cocaine response after cond. not corrected0.70.70.9-1.0-0.9-0.7-0.90.90.90.9-0.9-0.9-0.80.8
Cocaine response before conditioning3.03.64.32.02.01.21.8-1.8-1.8-1.92.12.02.1-1.9
Saline control response1.41.84.11.41.42.01.5-1.5-1.5-1.41.10.70.7-0.3
Bone: connectivity density0.20.30.90.40.5-0.10.4-0.3-0.4-0.50.70.80.7-0.9
Bone: cortical apparent density2.73.64.3-2.1-2.1-1.4-1.91.91.91.9-2.0-1.8-1.91.8
Bone: cortical area0.20.20.80.40.40.90.5-0.6-0.5-0.40.50.00.00.2
Bone: cortical porosity1.71.82.31.51.40.71.3-1.3-1.3-1.31.51.41.5-1.5
Bone: cortical porosity1.41.62.01.31.30.61.2-1.1-1.2-1.21.41.31.4-1.4
Bone: cortical thickness0.10.10.3-0.4-0.4-0.5-0.40.40.40.4-0.1-0.2-0.30.1
Bone: cortical thickness0.30.30.50.50.50.20.5-0.5-0.5-0.50.70.60.6-0.6
Bone: cortical tissue density2.63.54.1-2.0-2.0-1.4-1.91.91.91.9-1.9-1.8-1.81.7
Condit. Reinf. active minus inactive responses0.10.10.40.10.10.60.2-0.2-0.2-0.1-0.2-0.3-0.30.5
Condit. Reinf. active-inactive response ratio0.20.21.10.30.31.10.5-0.5-0.5-0.30.1-0.2-0.20.5
Condit. Reinf. active responses0.00.10.2-0.2-0.20.2-0.10.10.10.1-0.3-0.3-0.30.4
Condit. Reinf. inactive responses0.00.00.1-0.1-0.2-0.4-0.20.20.20.1-0.20.00.0-0.1
Incentive salience index mean0.10.10.50.20.20.70.3-0.3-0.3-0.2-0.1-0.1-0.10.4
Condit. Reinf. lever presses0.00.10.20.30.20.40.3-0.3-0.3-0.20.00.10.10.0
Condit. Reinf. active minus inactive responses5.26.412.82.82.83.62.9-3.0-2.9-2.72.01.61.6-0.7
Condit. Reinf. active-inactive response ratio1.61.72.51.41.41.61.5-1.5-1.5-1.41.10.91.0-0.6
Condit. Reinf. active responses6.08.418.63.23.14.33.4-3.4-3.3-3.02.21.61.6-0.6
Condit. Reinf. inactive responses3.03.79.62.12.03.12.2-2.3-2.2-2.01.40.90.9-0.1
Condit. Reinf. lever presses15.320.831.75.05.05.65.2-5.1-5.1-4.84.13.43.3-2.1
Condit. Reinf. lever reinforcers received7.310.320.83.63.54.63.7-3.7-3.7-3.42.52.01.9-0.9
Conditioned reinforcement - actives4.14.15.02.22.21.52.1-2.1-2.0-2.12.12.12.0-1.8
Conditioned reinforcement - inactives0.20.20.5-0.5-0.4-0.1-0.40.40.30.5-0.5-0.7-0.50.6
Conditioned locomotion4.45.36.62.52.41.32.2-2.2-2.2-2.32.52.62.4-2.3
Patch foraging indifference point 0 sec4.06.58.32.92.72.62.8-2.8-2.8-2.72.52.22.2-1.7
Patch foraging indifference point AUC0.30.41.1-0.4-0.50.3-0.30.20.30.4-0.8-0.9-0.81.0
Delay disc. indifference point, 0s delay0.50.61.00.90.81.00.9-0.9-0.8-0.80.70.50.5-0.2
Delay disc. indifference point, 16s delay0.00.00.2-0.1-0.3-0.5-0.20.20.20.1-0.20.10.0-0.1
Delay disc. indifference point, 2s delay0.20.20.90.50.20.90.4-0.5-0.5-0.4-0.0-0.0-0.10.4
Delay disc. indifference point, 24s delay1.01.01.8-1.0-1.2-1.3-1.21.11.11.0-1.0-0.6-0.70.4
Delay disc. indifference point, 4s delay0.20.21.00.40.11.00.4-0.5-0.4-0.3-0.1-0.2-0.30.7
Delay disc. indifference point, 8s delay0.00.00.00.0-0.1-0.00.1-0.00.0-0.0-0.00.0-0.10.1
Indifference point function ln k2.43.45.21.91.90.81.7-1.6-1.6-1.82.12.32.1-2.1
Indifference point function log k2.43.45.21.91.90.81.7-1.6-1.6-1.82.12.32.1-2.1
Patch foraging total patch changes 0 sec3.15.06.42.52.42.32.5-2.5-2.4-2.42.11.91.9-1.4
Patch foraging total patch changes 12 sec0.40.52.00.70.61.40.8-0.9-0.8-0.70.1-0.10.00.5
Patch foraging total patch changes 18 sec1.51.93.21.61.51.81.7-1.6-1.6-1.51.10.71.0-0.5
Patch foraging total patch changes 24 sec0.40.52.00.70.71.40.8-0.9-0.8-0.70.2-0.10.10.4
Patch foraging total patch changes 6 sec0.60.91.11.10.90.91.0-1.0-1.0-1.00.80.90.8-0.6
Patch foraging time to switch 0 sec3.04.77.4-2.4-2.3-2.7-2.52.42.42.3-2.0-1.7-1.61.0
Patch foraging water rate 0 sec3.35.36.52.62.52.42.5-2.5-2.5-2.42.32.12.0-1.5
Patch foraging water rate 12 sec2.84.25.22.22.31.82.1-2.1-2.2-2.12.11.92.0-1.7
Patch foraging water rate 18 sec1.11.53.21.31.41.81.4-1.4-1.4-1.31.10.90.8-0.5
Patch foraging water rate 24 sec2.02.83.61.71.71.01.6-1.5-1.6-1.71.81.91.9-1.9
Patch foraging water rate 6 sec1.62.43.11.61.71.41.6-1.5-1.6-1.61.61.51.5-1.4
Seeking ratio, delayed vs. immediate footshock0.60.71.9-1.0-0.8-1.4-1.01.00.90.9-0.6-0.6-0.4-0.0
Distance traveled before self-admin1.71.82.4-1.4-1.5-1.3-1.41.41.51.4-1.3-0.9-1.31.0
Distance traveled after self-admin0.20.20.9-0.10.1-0.9-0.20.20.1-0.00.40.60.7-0.9
Extensor digitorum longus weight0.31.32.8-1.0-1.2-0.1-0.90.80.91.0-1.3-1.4-1.51.7
Bone: elastic displacement1.41.63.8-1.4-1.4-1.9-1.51.51.51.3-1.0-0.7-0.60.2
Bone: elastic work1.01.33.9-1.2-1.2-2.0-1.31.41.31.2-0.7-0.4-0.4-0.1
Bone: endosteal estimation0.51.14.21.01.02.11.2-1.2-1.2-1.00.60.00.10.5
Bone: endosteal perimeter0.81.75.11.31.32.31.5-1.6-1.5-1.31.00.40.40.2
Epididymis fat weight1.33.05.3-1.6-1.8-0.5-1.41.41.51.6-2.0-2.1-2.12.3
Delta time in closed arm before/after self-admin4.34.26.6-1.9-2.1-0.6-1.71.71.82.0-2.3-2.5-2.52.6
Delta time in open arm before/after self-admin3.83.74.72.02.12.22.1-2.1-2.1-2.01.91.41.6-1.1
Diff in mean of infusions in LGA sessions4.04.45.2-2.3-2.2-1.8-2.22.22.22.2-2.1-2.0-2.01.6
Delay discount exponential model param0.20.20.40.40.60.30.4-0.4-0.5-0.40.60.40.5-0.5
Extinction: sum of active levers before priming0.10.10.2-0.3-0.3-0.3-0.30.30.30.4-0.3-0.4-0.30.3
Active lever presses in extinction session 64.84.67.12.22.10.72.0-1.9-1.9-2.12.42.72.4-2.5
Bone: final force0.00.00.0-0.2-0.2-0.1-0.10.20.20.2-0.0-0.2-0.20.2
Bone: final moment0.00.00.00.10.10.20.1-0.1-0.1-0.10.2-0.0-0.00.1
Food consumed during 24 hour testing period4.85.87.02.62.62.02.5-2.5-2.5-2.52.52.32.3-2.0
Glucose0.10.10.20.30.30.00.2-0.2-0.2-0.30.40.40.4-0.4
Heart weight1.31.92.51.61.51.21.5-1.5-1.5-1.51.31.31.2-1.0
Delay discount hyperbolic model param0.10.20.30.20.50.10.3-0.2-0.3-0.30.60.40.5-0.6
Intermittent access intake day 1-15 change0.80.80.91.00.90.80.9-0.9-0.9-0.90.90.90.7-0.7
Intermittent access intake escalation1.00.91.21.11.00.91.0-1.0-1.0-1.01.01.10.8-0.8
Intermittent access intake escalation 20.10.10.50.20.10.70.3-0.3-0.2-0.20.00.2-0.20.3
Intermitt. access day 1 inactive lever presses0.50.50.8-0.8-0.7-0.2-0.70.70.60.7-0.8-0.9-0.80.8
Intermitt. access day 15 inactive lever presses0.30.30.60.60.70.10.5-0.5-0.6-0.60.70.50.8-0.8
Intermitt. access escalation Index0.30.30.40.60.60.50.6-0.6-0.6-0.60.50.50.4-0.4
Intermittent access day 1 total infusions1.31.52.11.31.41.41.4-1.4-1.4-1.21.20.61.1-0.7
Intermittent access day 15 total infusions2.22.53.11.71.81.51.7-1.7-1.7-1.61.61.31.4-1.2
Intermittent access terminal intake (last 3 days)1.71.82.21.51.51.51.5-1.5-1.5-1.41.31.11.1-0.8
Intermittent access total infusions1.31.42.01.21.41.41.3-1.3-1.4-1.21.10.71.0-0.7
Intermittent access day 1 locomotion0.30.30.60.60.60.10.5-0.5-0.5-0.50.70.40.7-0.7
Intermittent access day 15 total locomotion1.82.02.51.61.51.11.4-1.4-1.4-1.51.51.41.4-1.2
Intermittent access total locomotion0.91.01.31.11.10.91.1-1.1-1.1-1.01.00.71.0-0.8
Intermittent access standard deviation0.00.00.10.1-0.00.20.1-0.1-0.1-0.1-0.1-0.1-0.20.3
Left kidney weight0.30.73.30.60.41.80.8-0.8-0.7-0.5-0.2-0.4-0.61.2
Right kidney weight0.10.41.80.40.11.40.5-0.5-0.4-0.3-0.2-0.3-0.71.1
Cocaine induced anxiety2.22.63.8-1.7-1.8-2.0-1.71.81.81.7-1.5-1.2-1.30.9
Post-drug Anxiety1.41.61.9-1.4-1.4-0.9-1.31.31.31.3-1.3-1.2-1.31.1
Baseline Anxiety0.90.92.60.91.11.61.1-1.1-1.1-0.90.80.50.5-0.2
Tail length0.72.29.70.40.23.10.9-0.9-0.8-0.3-0.8-1.5-1.52.6
Length with tail0.51.86.8-0.3-0.42.10.1-0.2-0.10.4-1.2-1.9-1.82.6
Length without tail0.10.30.5-0.6-0.6-0.7-0.60.60.60.6-0.4-0.6-0.50.3
Times rat made contact with spout0.80.91.6-0.9-1.0-0.3-0.80.80.80.9-1.1-1.2-1.21.3
Lifetime Intake1.71.92.71.51.61.61.5-1.5-1.6-1.41.40.81.2-0.8
Liver weight, left1.52.44.0-1.6-1.5-0.3-1.31.31.31.5-1.7-1.9-1.92.0
Liver weight, right3.45.79.3-2.4-2.4-0.6-2.02.02.02.3-2.8-2.9-2.83.1
Locomotor activity0.60.91.41.20.90.71.0-1.0-0.9-1.10.91.20.9-0.8
Locomotor testing distance1.52.53.91.91.62.01.8-1.8-1.7-1.71.31.31.1-0.7
Locomotor testing rearing0.20.31.50.50.31.20.5-0.6-0.5-0.4-0.1-0.1-0.30.6
Locomotion in novel chamber1.41.74.21.41.10.11.0-1.0-1.0-1.31.42.01.4-1.6
Locomotion in novel chamber post-restriction3.23.84.62.12.11.41.9-2.0-2.0-2.02.11.92.1-1.8
Fecal boli incidents, locomotor time 11.61.72.21.31.40.81.3-1.2-1.2-1.31.51.51.4-1.4
Change in fecal boli incidents, locomotor task1.31.31.6-1.2-1.2-0.9-1.31.21.11.2-1.1-1.1-1.10.9
Time >=10cm from walls, locomotor time 12.72.73.21.71.81.11.7-1.7-1.7-1.71.81.71.7-1.5
Bouts of movement, locomotor time 10.30.30.40.60.50.20.5-0.5-0.5-0.60.50.70.6-0.5
Total resting periods, locomotor time 10.40.40.80.60.6-0.10.5-0.5-0.5-0.60.60.90.9-0.9
Rest time, locomotor task time 10.10.10.50.10.3-0.40.2-0.1-0.1-0.20.60.40.5-0.7
Distance moved, locomotor task time 10.30.31.0-0.2-0.40.5-0.10.10.20.3-0.7-0.6-0.81.0
Vertical activity count, locomotor time 10.10.10.60.20.10.80.4-0.3-0.2-0.1-0.2-0.3-0.30.5
Time >=10cm from walls, locomotor time 21.41.52.21.31.41.51.4-1.4-1.4-1.31.20.81.0-0.6
Bouts of movement, locomotor time 20.20.20.8-0.0-0.20.8-0.1-0.1-0.00.1-0.5-0.4-0.60.9
Total resting periods, locomotor time 20.30.30.9-0.4-0.50.4-0.40.20.30.4-0.7-0.7-0.81.0
Rest time, locomotor task time 22.73.14.5-2.0-1.9-2.1-2.02.01.91.9-1.6-1.6-1.30.8
Distance moved, locomotor task time 22.42.84.91.91.82.22.0-2.0-1.9-1.81.41.21.0-0.6
Vertical activity count, locomotor time 20.60.72.20.90.81.51.1-1.0-1.0-0.80.50.20.20.2
Light reinforcement 12.75.06.0-2.4-2.5-2.3-2.42.42.42.3-2.4-2.1-1.81.4
Light reinforcement 20.10.20.8-0.4-0.4-0.9-0.40.50.50.3-0.2-0.00.1-0.3
Bone: marrow area0.40.83.40.80.81.91.0-1.0-1.0-0.80.4-0.1-0.00.6
Bone: maximum diameter1.01.94.41.51.42.11.6-1.6-1.6-1.41.20.70.7-0.1
Bone: maximum force0.00.00.10.10.10.20.2-0.1-0.1-0.10.30.00.00.0
Bone: maximum moment0.10.10.30.40.40.50.4-0.4-0.4-0.30.50.20.2-0.1
Mean time between licks in bursts2.13.010.41.81.73.22.0-2.1-2.0-1.71.00.30.40.6
Mean num. licks in bursts4.95.97.22.72.72.32.6-2.6-2.6-2.52.52.22.2-1.8
Cd content in liver1.11.21.6-1.1-1.2-0.5-1.11.01.01.1-1.3-1.2-1.11.3
Co content in liver0.80.92.91.01.01.71.1-1.1-1.1-0.90.60.20.30.2
Cu content in liver0.30.41.60.50.41.30.6-0.7-0.6-0.50.2-0.1-0.10.6
Fe content in liver0.10.10.1-0.3-0.3-0.1-0.20.20.20.3-0.3-0.4-0.30.3
K content in liver0.50.50.7-0.7-0.7-0.2-0.60.60.60.7-0.7-0.8-0.80.8
Mg content in liver0.10.10.20.30.30.50.3-0.3-0.3-0.30.20.10.1-0.0
Mn content in liver0.60.72.6-0.9-0.8-1.6-0.91.01.00.8-0.4-0.1-0.2-0.4
Na content in liver0.40.40.60.60.70.60.7-0.6-0.7-0.60.80.60.6-0.6
Rb content in liver0.60.71.21.00.91.11.0-1.0-1.0-0.90.60.50.5-0.3
Se content in liver2.83.45.2-2.1-2.0-2.3-2.12.12.12.0-1.6-1.4-1.40.8
Sr content in liver0.20.10.40.30.4-0.10.3-0.2-0.2-0.30.50.40.5-0.7
Zn content in liver4.55.06.72.52.42.62.5-2.5-2.5-2.42.11.81.7-1.2
Bone: minimum diameter0.30.52.2-0.2-0.21.20.1-0.1-0.10.2-0.5-1.0-1.01.5
Time in familiar zone, hab. session 10.10.10.2-0.2-0.20.2-0.10.10.10.2-0.3-0.4-0.40.5
Time in novel zone, hab. session 10.30.30.4-0.6-0.6-0.5-0.60.60.60.6-0.4-0.4-0.50.4
Total zone transitions, hab. session 10.20.30.80.40.4-0.30.2-0.3-0.3-0.40.60.70.7-0.9
Total locomotion distance, hab. session 11.72.53.7-1.5-1.7-0.4-1.51.31.31.5-1.9-1.8-1.81.9
Locomotion velocity, hab. session 11.01.42.2-1.2-1.3-0.2-1.11.01.01.1-1.5-1.4-1.41.5
Time in familiar zone, hab. session 21.31.32.71.21.31.61.3-1.3-1.3-1.20.90.70.7-0.4
Time in novel zone, hab. session 20.20.20.8-0.5-0.5-0.9-0.60.50.50.4-0.2-0.1-0.1-0.1
Total zone transitions, hab. session 22.02.63.11.81.71.11.6-1.6-1.6-1.71.71.71.7-1.6
Total locomotion distance, hab. session 20.40.61.8-0.5-0.60.4-0.40.30.40.5-0.9-1.1-1.01.3
Locomotion velocity, hab. session 20.70.92.5-0.8-0.80.3-0.60.50.60.8-1.2-1.3-1.31.6
Novel to familiar place preference ratio0.10.10.10.30.30.00.2-0.3-0.3-0.30.40.30.3-0.3
Novelty place preference0.10.10.10.30.30.00.2-0.3-0.3-0.30.40.30.3-0.3
Time in novel zone, NPP test0.20.20.40.60.50.20.5-0.5-0.5-0.50.60.50.5-0.4
Total zone transitions, NPP test0.40.60.90.80.80.30.6-0.7-0.7-0.80.91.00.9-1.0
Total locomotion distance, NPP test1.01.42.4-1.1-1.2-0.3-1.00.91.01.1-1.3-1.4-1.41.6
Locomotion velocity, NPP test1.52.13.0-1.5-1.5-0.6-1.41.31.31.4-1.6-1.7-1.71.7
Intraocular pressure0.50.61.10.80.80.10.7-0.7-0.7-0.80.91.01.0-1.1
Delta distance traveled before/after self-admin2.42.63.51.61.81.11.5-1.6-1.7-1.61.81.41.9-1.6
Delta ambulatory time before/after self-admin2.83.04.51.71.91.01.6-1.6-1.8-1.71.91.72.1-1.9
Parametrial fat weight1.63.24.7-1.9-1.8-0.9-1.61.61.61.8-1.9-2.2-2.02.0
Pavlov. Cond. lever latency1.11.42.1-1.4-1.3-1.5-1.31.31.31.2-1.0-0.9-0.90.6
Pavlov. Cond. magazine entry latency2.53.25.32.02.02.32.0-2.0-2.0-1.91.61.31.3-0.8
Pavlov. Cond. change in total contacts1.21.32.41.31.31.61.4-1.3-1.3-1.20.90.80.8-0.5
Pavlov. Cond. index score2.43.15.42.01.92.32.0-2.0-2.0-1.81.51.21.2-0.7
Pavlov. Cond. latency score2.43.05.12.01.92.32.0-2.0-2.0-1.81.51.21.2-0.7
Pavlov. Cond. lever contacts0.91.02.31.11.11.51.2-1.2-1.2-1.10.70.60.6-0.2
Pavlov. Cond. magazine entry number3.24.05.9-2.2-2.2-2.4-2.22.22.22.1-1.9-1.5-1.51.0
Pavlov. Cond. intertrial magazine entries0.81.01.5-1.1-1.1-1.2-1.11.11.11.0-0.9-0.7-0.70.4
Pavlov. Cond. lever-magazine prob. diff.2.02.54.31.81.72.11.8-1.8-1.8-1.71.31.11.1-0.6
Pavlov. Cond. response bias0.91.12.31.21.11.51.2-1.2-1.2-1.10.80.60.6-0.3
Pavlov. Cond. lever latency16.322.030.8-5.2-5.2-5.6-5.35.25.25.0-4.4-3.6-3.62.4
Pavlov. Cond. magazine entry latency4.85.66.82.62.62.32.6-2.5-2.5-2.52.32.12.1-1.7
Pavlov. Cond. change in total contacts13.518.623.24.84.74.84.8-4.8-4.7-4.64.13.53.5-2.5
Pavlov. Cond. index score13.417.222.74.64.64.84.7-4.6-4.6-4.43.93.33.3-2.3
Pavlov. Cond. latency score12.215.219.64.34.34.44.4-4.3-4.3-4.13.73.13.1-2.2
Pavlov. Cond. lever contacts17.023.232.45.45.35.75.4-5.4-5.3-5.14.53.73.7-2.5
Pavlov. Cond. magazine entry number8.410.312.5-3.5-3.5-3.2-3.53.43.43.4-3.2-2.8-2.82.3
Pavlov. Cond. intertrial magazine entries0.50.61.9-0.6-0.60.5-0.40.40.40.6-0.8-1.1-1.11.4
Pavlov. Cond. lever-magazine prob. diff.12.215.621.54.44.34.64.5-4.4-4.4-4.23.73.13.1-2.1
Pavlov. Cond. response bias17.824.332.05.55.45.75.5-5.5-5.4-5.24.63.93.9-2.7
Time in closed arm before self-admin4.75.47.82.32.40.82.0-2.0-2.1-2.32.62.82.7-2.8
Time in closed arm after self-admin0.30.31.4-0.4-0.4-1.2-0.60.60.60.5-0.20.10.0-0.4
Time in open arm before self-admin6.16.78.5-2.8-2.9-2.3-2.62.72.72.6-2.7-2.3-2.52.1
Time in open arm after self-admin0.20.31.0-0.2-0.20.70.0-0.00.00.1-0.5-0.7-0.71.0
Bone: periosteal estimation0.51.03.51.00.91.91.2-1.2-1.1-0.90.70.10.20.4
Bone: periosteal perimeter0.71.13.11.11.11.81.3-1.3-1.3-1.10.90.40.40.1
Bone: post-yield work0.20.20.30.50.50.50.5-0.5-0.5-0.50.60.40.4-0.3
Progressive ratio test 1 active lever presses0.00.00.1-0.3-0.1-0.3-0.20.20.20.2-0.2-0.4-0.10.1
Progressive ratio test 1 breakpoint0.10.10.2-0.3-0.2-0.1-0.20.20.20.3-0.3-0.5-0.20.3
Progressive ratio test 1 inactive lever presses0.40.40.80.60.80.90.7-0.7-0.8-0.60.5-0.10.6-0.3
Progressive ratio test 2 active lever presses0.60.71.30.90.91.21.0-1.0-0.9-0.90.70.50.5-0.2
Progressive ratio test 2 breakpoint0.60.71.51.00.91.21.0-1.0-0.9-0.90.70.50.5-0.2
Progressive ratio test 2 inactive lever presses1.31.51.91.31.41.01.3-1.3-1.3-1.31.30.91.3-1.1
Incentive Sensitization - Responses1.51.53.41.41.21.81.4-1.4-1.3-1.31.00.90.6-0.2
Incentive Sensitization - Breakpoint1.51.52.91.41.21.71.4-1.4-1.3-1.31.01.00.7-0.4
Sum of active levers in priming session hrs 5-60.10.10.5-0.1-0.3-0.7-0.30.30.30.1-0.00.30.1-0.3
Progressive ratio0.10.10.30.30.3-0.20.2-0.2-0.2-0.30.40.60.5-0.6
Food seeking constrained by brief footshock0.30.41.60.60.51.30.7-0.7-0.6-0.60.20.1-0.10.4
Seeking ratio, punishment vs. effort0.30.31.60.20.11.30.4-0.4-0.3-0.2-0.2-0.5-0.51.0
Retroperitoneal fat weight6.320.830.7-4.6-4.7-1.6-4.04.04.04.5-5.1-5.4-5.45.5
Reaction time number correct0.60.92.20.70.8-0.20.5-0.5-0.5-0.71.21.51.2-1.5
Reaction time mean minus median0.40.51.20.80.81.10.9-0.9-0.8-0.70.40.30.3-0.1
Reaction time mean minus median AUC1.11.41.81.31.31.21.3-1.3-1.3-1.31.00.91.0-0.8
Reaction time num false alarms2.73.74.7-2.1-2.2-1.6-2.02.02.02.0-2.0-1.7-1.91.7
Reaction time num false alarms AUC1.31.82.3-1.4-1.5-1.2-1.41.41.41.4-1.3-1.1-1.21.0
Reaction time trials correct on left0.60.92.20.70.8-0.20.5-0.5-0.5-0.71.21.51.2-1.5
Reaction time trials on left0.60.92.20.70.7-0.20.5-0.5-0.5-0.71.21.51.2-1.5
Reaction time mean1.21.62.3-1.3-1.4-0.9-1.21.21.31.3-1.5-1.3-1.31.3
Reaction time mean AUC1.31.82.3-1.4-1.4-1.1-1.41.41.41.4-1.5-1.4-1.21.1
Median of all reaction times1.82.42.9-1.6-1.7-1.4-1.61.61.61.6-1.7-1.5-1.41.3
Reaction time omissions0.50.71.0-0.9-0.9-0.6-0.90.80.80.8-1.0-0.9-0.80.8
Reaction time false alarm rate2.13.03.7-1.8-1.9-1.1-1.71.71.71.8-1.9-1.8-1.81.7
Reaction time premature initiation rate0.50.73.70.40.51.90.8-0.8-0.7-0.4-0.1-0.5-0.51.1
Reaction time premature initiations0.60.92.80.91.01.71.1-1.1-1.1-0.90.70.50.30.0
Std. dev. reaction times0.20.31.2-0.1-0.30.7-0.10.00.10.2-0.7-0.8-0.81.1
Reaction time trials completed0.60.92.20.70.7-0.20.5-0.5-0.5-0.71.21.51.2-1.5
Reaction time trials AUC0.50.71.90.60.6-0.20.4-0.4-0.4-0.61.01.41.0-1.3
Run reversals in cocaine runway, females3.23.17.0-1.6-1.60.4-1.21.21.21.5-2.0-2.5-2.22.6
Run reversals in cocaine runway, males0.00.00.1-0.2-0.1-0.3-0.20.20.10.2-0.1-0.20.0-0.1
Latency to leave start box in cocaine runway4.04.35.4-2.3-2.2-1.3-2.02.12.02.2-2.2-2.3-2.11.9
Latency to leave start box in cocaine runway, F4.04.46.0-2.3-2.2-1.0-2.01.91.92.1-2.3-2.5-2.32.3
Latency to leave start box in cocaine runway, M0.10.10.5-0.4-0.3-0.7-0.40.50.40.4-0.1-0.00.0-0.2
Std. dev. time between licks in bursts0.50.62.60.30.21.60.6-0.6-0.5-0.3-0.2-0.7-0.61.2
Total sessions with >9 infusions3.84.25.72.22.41.92.2-2.2-2.3-2.12.11.62.0-1.6
Short access day 1 total inactive lever presses0.00.00.2-0.20.1-0.0-0.10.1-0.00.1-0.0-0.50.1-0.1
Short access day 10 total inactive lever presses0.00.10.1-0.2-0.3-0.4-0.30.30.30.2-0.20.1-0.1-0.0
Short access day 1 total infusions2.62.84.31.81.92.11.9-1.8-1.9-1.71.51.11.3-0.9
Short access day 10 total infusions1.11.22.71.21.21.61.3-1.3-1.3-1.10.90.50.7-0.3
Short access total infusions1.11.32.41.11.41.51.3-1.3-1.3-1.11.00.40.9-0.5
Short access day 1 locomotion3.33.54.31.92.11.21.9-1.8-1.9-1.92.11.82.1-1.9
Short access day 10 total locomotion0.10.20.30.50.30.50.5-0.5-0.4-0.50.30.50.10.0
Short access total locomotion0.20.20.30.50.50.30.5-0.5-0.5-0.50.50.40.4-0.4
One hour access (0.3 mA shock)2.12.43.41.71.71.81.7-1.7-1.7-1.61.51.31.2-0.8
Compulsive drug intake0.20.20.60.20.1-0.60.1-0.1-0.0-0.20.40.80.5-0.7
One hour access (shock baseline)1.41.63.21.41.41.81.4-1.4-1.4-1.31.10.80.8-0.4
Social response proportion0.60.71.1-0.9-0.8-0.1-0.70.70.70.8-0.9-1.0-1.01.0
Social responses1.11.42.7-1.1-1.00.0-0.80.90.91.1-1.4-1.6-1.51.6
Social time1.92.54.3-1.8-1.6-2.1-1.81.91.81.7-1.5-1.2-1.00.5
Soleus weight0.82.35.9-1.3-1.40.3-1.00.91.01.3-1.7-2.0-2.12.4
Bone: stiffness0.40.71.2-0.9-0.9-0.3-0.70.70.70.8-0.8-1.0-1.01.1
Tibialis anterior weight0.00.10.6-0.0-0.10.50.0-0.1-0.10.1-0.3-0.4-0.50.8
Time to tail flick, vehicle, before self-admin0.00.00.1-0.0-0.0-0.4-0.10.10.10.00.10.30.2-0.2
Time to tail flick, vehicle, after self-admin3.74.05.22.12.31.62.1-2.0-2.1-2.02.21.72.1-1.8
Time to tail flick, test, before self-admin0.10.10.50.40.30.70.4-0.4-0.4-0.30.1-0.1-0.10.3
Time to tail flick, test, after self-admin0.20.31.0-0.1-0.00.90.1-0.2-0.10.1-0.3-0.6-0.61.0
Delta time to tail flick, vehicle, before/after SA2.52.43.41.61.91.51.7-1.6-1.7-1.61.61.01.6-1.2
Delta time to tail flick, test, before/after SA0.40.30.5-0.7-0.6-0.3-0.60.60.60.6-0.6-0.6-0.60.6
Tibia length2.67.38.52.92.91.82.7-2.7-2.7-2.82.92.82.8-2.6
Ambulatory time before self-admin1.31.42.0-1.2-1.4-1.4-1.31.31.41.2-1.1-0.7-1.00.7
Ambulatory time after self-admin0.60.62.20.40.5-0.70.2-0.2-0.3-0.50.91.11.2-1.5
Bone: tissue strength0.40.41.40.30.3-0.80.1-0.0-0.1-0.30.70.80.8-1.2
Total heroin consumption0.50.60.80.80.80.30.7-0.7-0.7-0.80.90.90.9-0.9
Bone: trabecular number0.40.61.9-0.8-0.8-1.4-0.90.90.90.7-0.5-0.1-0.2-0.2
Bone: trabecular spacing1.01.21.71.21.21.11.1-1.2-1.2-1.11.30.91.0-0.8
Bone: trabecular thickness0.30.40.7-0.7-0.7-0.5-0.50.60.70.6-0.8-0.6-0.60.6
Bone: trabecular tissue density2.83.95.7-2.0-2.1-0.8-1.81.71.81.9-2.2-2.2-2.32.4
Water consumed over 24 hours0.40.51.0-0.7-0.7-1.0-0.80.80.80.7-0.5-0.4-0.40.1
Number of responses in last shaping day0.10.10.40.20.20.60.4-0.3-0.3-0.20.0-0.1-0.10.3