Intermitt. access escalation Index

IntA_Inf_Z_Term / IntA_Inf_Z_D1

Tags: Behavior · Intermittent access · Cocaine

Project: p50_paul_meyer_2020

3 loci · 3 genes with independent associations · 3 total associated genes

Significant Loci

#	Chr	Start pos	End pos	# assoc genes	# joint models	Best TWAS P	Best GWAS P	Cond GWAS P	Joint genes
1	chr1	68674594	70070028	1	1	3.68e-12	1.04e-01	6.34e-73	Rdh13
2	chr7	14449451	15768722	1	1	8.16e-13	2.40e-01	1.00e+00	LOC102551633
3	chr14	34177603	35456143	1	1	6.64e-09	7.69e-03	1.90e-07	Ociad2

Pleiotropic Associations

Trait	Chi² ratio	# genes⁺	# genes⁺⁺	% genes⁺⁺	Corr P	Genes
BMI with tail	13.8	1	1	33.3	1e+00	Ociad2
BMI without tail	4.73	1	0	0	1e+00	Ociad2
Body weight	3.71	1	0	0	1e+00	Ociad2
Epididymis fat weight	2.97	1	0	0	1e+00	Rdh13
Glucose	4.51	1	0	0	1e+00	Rdh13
Heart weight	9.93	1	0	0	1e+00	Ociad2
Left kidney weight	28.27	1	1	33.3	1e+00	Ociad2
Right kidney weight	6.23	1	0	0	1e+00	Ociad2
Length with tail	2.39	1	0	0	1e+00	Ociad2
Extensor digitorum longus weight	1.79	1	0	0	1e+00	Ociad2
Tibia length	7.31	1	0	0	1e+00	Ociad2
Patch foraging indifference point 0 sec	7.38	2	0	0	1e+00	LOC102551633 Rdh13
Indifference point function ln k	12.06	2	0	0	1e+00	Ociad2 Rdh13
Indifference point function log k	12.06	2	0	0	1e+00	Ociad2 Rdh13
Patch foraging total patch changes 0 sec	6.72	2	0	0	1e+00	LOC102551633 Rdh13
Patch foraging total patch changes 18 sec	13.67	1	0	0	1e+00	Ociad2
Patch foraging total patch changes 24 sec	10.01	2	0	0	1e+00	Ociad2 Rdh13
Patch foraging total patch changes 6 sec	5.65	1	0	0	1e+00	LOC102551633
Patch foraging time to switch 0 sec	8.55	2	0	0	1e+00	Ociad2 Rdh13
Patch foraging water rate 12 sec	8.13	1	0	0	1e+00	Rdh13
Patch foraging water rate 18 sec	4.45	1	0	0	1e+00	Rdh13
Patch foraging water rate 24 sec	4.17	1	0	0	1e+00	Rdh13
Patch foraging water rate 6 sec	5.4	1	0	0	1e+00	Ociad2
Locomotor activity	4.12	2	0	0	1e+00	LOC102551633 Ociad2
Locomotor testing distance	3.81	2	0	0	1e+00	LOC102551633 Ociad2
Light reinforcement 1	7.49	1	0	0	1e+00	Rdh13
Reaction time num false alarms	17.2	1	0	0	1e+00	Ociad2
Reaction time num false alarms AUC	8.56	2	0	0	1e+00	Ociad2 Rdh13
Reaction time mean	7.88	1	0	0	1e+00	Ociad2
Reaction time mean AUC	8.2	1	0	0	1e+00	Ociad2
Median of all reaction times	6.69	1	0	0	1e+00	Ociad2
Reaction time omissions	25.94	1	1	33.3	1e+00	Ociad2
Reaction time false alarm rate	6.97	2	0	0	1e+00	Ociad2 Rdh13
Conditioned locomotion	7.75	2	0	0	1e+00	Ociad2 Rdh13
Saline control response	11.54	2	0	0	1e+00	Ociad2 Rdh13
Condit. Reinf. active minus inactive responses	13.13	1	0	0	1e+00	Ociad2
Condit. Reinf. active-inactive response ratio	9.95	2	0	0	1e+00	Ociad2 Rdh13
Condit. Reinf. active responses	18.34	1	0	0	1e+00	Ociad2
Condit. Reinf. inactive responses	8.56	2	0	0	1e+00	Ociad2 Rdh13
Condit. Reinf. lever presses	5.66	1	0	0	1e+00	Ociad2
Condit. Reinf. lever reinforcers received	12.87	1	0	0	1e+00	Ociad2
Pavlov. Cond. change in total contacts	8.59	1	0	0	1e+00	Rdh13
Conditioned reinforcement - actives	8.02	2	0	0	1e+00	LOC102551633 Rdh13
Conditioned reinforcement - inactives	5.74	1	0	0	1e+00	LOC102551633
Conditioned locomotion	53.64	1	1	33.3	1e+00	LOC102551633
Intermittent access intake day 1-15 change	5.83	1	0	0	1e+00	Rdh13
Intermittent access intake escalation 2	13.41	1	0	0	1e+00	LOC102551633
Intermitt. access day 1 inactive lever presses	16.85	1	0	0	1e+00	Rdh13
Intermitt. access day 15 inactive lever presses	10.79	1	0	0	1e+00	Rdh13
Intermittent access day 1 total infusions	19.51	1	0	0	1e+00	LOC102551633
Intermittent access day 15 total infusions	6.27	1	0	0	1e+00	LOC102551633
Intermittent access terminal intake (last 3 days)	58.42	1	1	33.3	1e+00	LOC102551633
Intermittent access total infusions	12.85	1	0	0	1e+00	LOC102551633
Intermittent access day 15 total locomotion	32.88	1	1	33.3	1e+00	LOC102551633
Intermittent access total locomotion	12.95	1	0	0	1e+00	LOC102551633
Post-drug Anxiety	21.14	1	0	0	1e+00	Ociad2
Baseline Anxiety	6.35	2	0	0	1e+00	Ociad2 Rdh13
Lifetime Intake	15.71	1	0	0	1e+00	LOC102551633
Incentive Sensitization - Responses	8.44	1	0	0	1e+00	LOC102551633
Incentive Sensitization - Breakpoint	6.89	1	0	0	1e+00	LOC102551633
Progressive ratio test 1 active lever presses	16.85	1	0	0	1e+00	LOC102551633
Progressive ratio test 1 breakpoint	36.73	1	1	33.3	1e+00	LOC102551633
Progressive ratio test 1 inactive lever presses	19.6	2	1	33.3	1e+00	LOC102551633 Ociad2
Progressive ratio test 2 inactive lever presses	22.31	1	0	0	1e+00	LOC102551633
Short access day 1 total inactive lever presses	7.07	1	0	0	1e+00	LOC102551633
Short access day 10 total inactive lever presses	17.14	1	0	0	1e+00	LOC102551633
Short access day 1 total infusions	71.59	1	1	33.3	1e+00	LOC102551633
Short access day 10 total infusions	30.94	1	1	33.3	1e+00	LOC102551633
Short access total infusions	43.84	1	1	33.3	1e+00	LOC102551633
Short access day 1 locomotion	22.2	1	0	0	1e+00	LOC102551633
One hour access (shock baseline)	6.09	1	0	0	1e+00	LOC102551633
Number of responses in last shaping day	15.26	2	0	0	1e+00	LOC102551633 Rdh13
Locomotion velocity, session 1	12.03	1	0	0	1e+00	Rdh13
Locomotion distance, session 1	5.22	1	0	0	1e+00	Rdh13
Stereotopy head waving bouts, day 3	5.09	1	0	0	1e+00	Ociad2
Locomotion velocity, session 8	5.38	1	0	0	1e+00	Rdh13
Degree of sensitization distance	11.08	1	0	0	1e+00	LOC102551633
Total zone transitions, hab. session 1	4.15	1	0	0	1e+00	Rdh13
Time in familiar zone, hab. session 2	5.59	1	0	0	1e+00	Rdh13
Total zone transitions, hab. session 2	5.01	1	0	0	1e+00	Ociad2
Total locomotion distance, hab. session 2	4.98	1	0	0	1e+00	Ociad2
Locomotion velocity, hab. session 2	4.29	1	0	0	1e+00	Ociad2
Pavlov. Cond. lever latency	5.45	1	0	0	1e+00	LOC102551633
Pavlov. Cond. magazine entry latency	6.8	1	0	0	1e+00	Ociad2
Pavlov. Cond. latency score	4.54	1	0	0	1e+00	LOC102551633
Pavlov. Cond. lever contacts	5.74	1	0	0	1e+00	LOC102551633
Pavlov. Cond. magazine entry number	8.37	1	0	0	1e+00	Ociad2
Pavlov. Cond. intertrial magazine entries	8.55	2	0	0	1e+00	Ociad2 Rdh13
Bone: apparent density	6.77	1	0	0	1e+00	Ociad2
Bone: cortical thickness	10.85	1	0	0	1e+00	Ociad2
Bone: endosteal estimation	3.8	1	0	0	1e+00	Ociad2
Bone: final force	5.82	2	0	0	1e+00	LOC102551633 Ociad2
Bone: final moment	4.2	2	0	0	1e+00	LOC102551633 Ociad2
Bone: marrow area	3.54	1	0	0	1e+00	Ociad2
Bone: maximum force	5.85	2	0	0	1e+00	LOC102551633 Ociad2
Bone: maximum moment	4.23	2	0	0	1e+00	LOC102551633 Ociad2
Bone: minimum diameter	9.13	1	0	0	1e+00	Ociad2
Bone: stiffness	4.84	2	0	0	1e+00	LOC102551633 Ociad2
Bone: trabecular number	5.07	1	0	0	1e+00	Ociad2
Distance traveled before self-admin	53.87	1	1	33.3	1e+00	LOC102551633
Distance traveled after self-admin	21.69	3	1	33.3	1e+00	LOC102551633 Ociad2 Rdh13
Delta time in open arm before/after self-admin	19.63	1	0	0	1e+00	Rdh13
Diff in mean of infusions in LGA sessions	16.85	1	0	0	1e+00	Rdh13
Extinction: sum of active levers before priming	16.96	3	0	0	1e+00	LOC102551633 Ociad2 Rdh13
Active lever presses in extinction session 6	16.11	1	0	0	1e+00	Rdh13
Delta distance traveled before/after self-admin	8.2	2	0	0	1e+00	Ociad2 Rdh13
Delta ambulatory time before/after self-admin	9.91	2	0	0	1e+00	LOC102551633 Ociad2
Time in closed arm after self-admin	8.81	2	0	0	1e+00	LOC102551633 Ociad2
Time in open arm before self-admin	28.75	1	1	33.3	1e+00	LOC102551633
Time in open arm after self-admin	10.68	2	0	0	1e+00	LOC102551633 Rdh13
Sum of active levers in priming session hrs 5-6	18.32	2	0	0	1e+00	LOC102551633 Rdh13
Time to tail flick, vehicle, before self-admin	30.19	2	1	33.3	1e+00	LOC102551633 Ociad2
Time to tail flick, vehicle, after self-admin	32.16	2	1	33.3	1e+00	LOC102551633 Rdh13
Time to tail flick, test, before self-admin	17.68	2	1	33.3	1e+00	Ociad2 Rdh13
Delta time to tail flick, vehicle, before/after SA	73.62	2	1	33.3	1e+00	LOC102551633 Rdh13
Delta time to tail flick, test, before/after SA	10.58	1	0	0	1e+00	Rdh13
Ambulatory time before self-admin	12.39	2	0	0	1e+00	LOC102551633 Rdh13
Ambulatory time after self-admin	14.51	2	0	0	1e+00	LOC102551633 Rdh13
Total heroin consumption	19.38	2	1	33.3	1e+00	LOC102551633 Ociad2
Delay disc. indifference point, 0s delay	9.05	1	0	0	1e+00	Rdh13
Delay disc. indifference point, 16s delay	8.18	1	0	0	1e+00	Rdh13
Bouts of movement, locomotor time 1	5.94	1	0	0	1e+00	Rdh13
Vertical activity count, locomotor time 1	13.87	1	0	0	1e+00	Rdh13
Seeking ratio, delayed vs. immediate footshock	7.74	2	0	0	1e+00	LOC102551633 Rdh13
Locomotion in novel chamber	4.79	1	0	0	1e+00	Rdh13
Food seeking constrained by brief footshock	26.2	1	1	33.3	1e+00	Rdh13
Seeking ratio, punishment vs. effort	8.22	1	0	0	1e+00	Rdh13
Run reversals in cocaine runway, females	7.35	1	0	0	1e+00	Ociad2
Run reversals in cocaine runway, males	10.49	1	0	0	1e+00	Ociad2
Cd content in liver	7.84	1	0	0	1e+00	Ociad2
Co content in liver	12.69	1	0	0	1e+00	LOC102551633
Cu content in liver	5.79	1	0	0	1e+00	Ociad2
Fe content in liver	7.51	1	0	0	1e+00	LOC102551633
K content in liver	8.84	2	0	0	1e+00	LOC102551633 Ociad2
Na content in liver	25.96	2	1	33.3	1e+00	LOC102551633 Rdh13
Rb content in liver	11.23	2	0	0	1e+00	LOC102551633 Ociad2
Se content in liver	27.17	2	1	33.3	1e+00	LOC102551633 Ociad2
Sr content in liver	21.8	2	0	0	1e+00	Ociad2 Rdh13

Associations by panel

Tissue	RNA modality	# hits	% hits/tests	Avg chisq
Adipose	alternative polyA	0	0	0.93
Adipose	alternative TSS	0	0	0.83
Adipose	gene expression	0	0	0.9
Adipose	isoform ratio	0	0	0.9
Adipose	intron excision ratio	0	0	0.9
Adipose	mRNA stability	0	0	0.9
BLA	alternative polyA	0	0	0.95
BLA	alternative TSS	0	0	0.84
BLA	gene expression	0	0	0.89
BLA	isoform ratio	0	0	0.83
BLA	intron excision ratio	0	0	0.9
BLA	mRNA stability	0	0	0.87
Brain	alternative polyA	0	0	0.9
Brain	alternative TSS	0	0	0.85
Brain	gene expression	0	0	0.87
Brain	isoform ratio	0	0	0.85
Brain	intron excision ratio	0	0	0.88
Brain	mRNA stability	0	0	0.89
Eye	alternative polyA	0	0	0.92
Eye	alternative TSS	0	0	0.85
Eye	gene expression	0	0	0.84
Eye	isoform ratio	0	0	0.79
Eye	intron excision ratio	0	0	0.98
Eye	mRNA stability	0	0	0.85
IL	alternative polyA	0	0	0.95
IL	alternative TSS	0	0	0.84
IL	gene expression	0	0	0.91
IL	isoform ratio	0	0	0.85
IL	intron excision ratio	0	0	0.94
IL	mRNA stability	0	0	0.96
LHb	alternative polyA	0	0	0.91
LHb	alternative TSS	0	0	0.99
LHb	gene expression	0	0	0.89
LHb	isoform ratio	0	0	0.85
LHb	intron excision ratio	0	0	0.96
LHb	mRNA stability	0	0	0.94
Liver	alternative polyA	0	0	0.89
Liver	alternative TSS	0	0	0.91
Liver	gene expression	0	0	0.89
Liver	isoform ratio	0	0	0.92
Liver	intron excision ratio	1	0	0.86
Liver	mRNA stability	0	0	0.91
NAcc	alternative polyA	0	0	0.9
NAcc	alternative TSS	0	0	0.94
NAcc	gene expression	0	0	0.88
NAcc	isoform ratio	0	0	0.85
NAcc	intron excision ratio	0	0	0.9
NAcc	mRNA stability	0	0	0.91
OFC	alternative polyA	0	0	0.93
OFC	alternative TSS	0	0	0.8
OFC	gene expression	0	0	0.9
OFC	isoform ratio	0	0	0.9
OFC	intron excision ratio	0	0	0.89
OFC	mRNA stability	0	0	0.88
PL	alternative polyA	0	0	0.88
PL	alternative TSS	0	0	0.83
PL	gene expression	0	0	0.89
PL	isoform ratio	0	0	0.86
PL	intron excision ratio	0	0	0.88
PL	mRNA stability	1	0	0.92
pVTA	alternative polyA	0	0	0.88
pVTA	alternative TSS	0	0	0.89
pVTA	gene expression	0	0	0.88
pVTA	isoform ratio	0	0	0.83
pVTA	intron excision ratio	0	0	0.89
pVTA	mRNA stability	0	0	0.9
RMTg	alternative polyA	1	0.2	0.97
RMTg	alternative TSS	0	0	0.95
RMTg	gene expression	0	0	0.96
RMTg	isoform ratio	0	0	0.89
RMTg	intron excision ratio	0	0	0.93
RMTg	mRNA stability	0	0	0.96