Intermitt. access escalation Index

IntA_Inf_Z_Term / IntA_Inf_Z_D1

Tags: Behavior · Intermittent access · Cocaine

Project: p50_paul_meyer_2020

1 loci · 1 genes with independent associations · 1 total associated genes

Significant Loci

#	Chr	Start pos	End pos	# assoc genes	# joint models	Best TWAS P	Best GWAS P	Cond GWAS P	Joint genes
1	7	51230254	52627618	1	1	1.01e-08	2.11e-01	1.44e-39	Ptprb

Pleiotropic Associations

Trait	Chi² ratio	# genes⁺	Corr P	Genes
BMI with tail	2.91	1	1e+00	Ptprb
BMI without tail	8.12	1	1e+00	Ptprb
Body weight	2.12	1	1e+00	Ptprb
Heart weight	7.41	1	1e+00	Ptprb
Extensor digitorum longus weight	1.08	1	1e+00	Ptprb
Reaction time omissions	3.37	1	1e+00	Ptprb
Intermitt. access day 15 inactive lever presses	7.08	1	1e+00	Ptprb
Baseline Anxiety	4.73	1	1e+00	Ptprb
Progressive ratio test 1 inactive lever presses	4.87	1	1e+00	Ptprb
Total sessions with >9 infusions	4.49	1	1e+00	Ptprb
Short access day 1 total inactive lever presses	12.61	1	1e+00	Ptprb
Short access day 10 total inactive lever presses	4.89	1	1e+00	Ptprb
Short access day 10 total infusions	8.1	1	1e+00	Ptprb
Short access total infusions	3.99	1	1e+00	Ptprb
Compulsive drug intake	11.97	1	1e+00	Ptprb
Number of responses in last shaping day	5	1	1e+00	Ptprb
Active lever presses in extinction session 6	6.17	1	1e+00	Ptprb
Sum of active levers in priming session hrs 5-6	6.79	1	1e+00	Ptprb
Time to tail flick, test, after self-admin	7.39	1	1e+00	Ptprb
Delay disc. indifference point, 0s delay	4.07	1	1e+00	Ptprb
Delay disc. indifference point, 4s delay	7	1	1e+00	Ptprb
Distance moved, locomotor task time 1	7.23	1	1e+00	Ptprb
Vertical activity count, locomotor time 2	5.84	1	1e+00	Ptprb
Run reversals in cocaine runway, females	6.27	1	1e+00	Ptprb
Run reversals in cocaine runway, males	20.35	1	1e+00	Ptprb
Latency to leave start box in cocaine runway	17.58	1	1e+00	Ptprb
Latency to leave start box in cocaine runway, F	4.59	1	1e+00	Ptprb
Latency to leave start box in cocaine runway, M	10.06	1	1e+00	Ptprb
Rb content in liver	9.3	1	1e+00	Ptprb

Associations by panel

Tissue	RNA modality	# hits	Avg chisq
Adipose	alternative polyA	0	0.87
Adipose	alternative TSS	0	0.88
Adipose	gene expression	0	0.91
Adipose	isoform ratio	1	0.89
Adipose	intron excision ratio	0	0.92
Adipose	mRNA stability	0	0.91
BLA	alternative polyA	0	1
BLA	alternative TSS	0	0.88
BLA	gene expression	0	0.88
BLA	isoform ratio	0	0.88
BLA	intron excision ratio	0	0.93
BLA	mRNA stability	0	0.86
Brain	alternative polyA	0	0.91
Brain	alternative TSS	0	0.9
Brain	gene expression	0	0.88
Brain	isoform ratio	0	0.88
Brain	intron excision ratio	0	0.89
Brain	mRNA stability	0	0.9
Eye	alternative polyA	0	0.88
Eye	alternative TSS	0	0.84
Eye	gene expression	0	0.88
Eye	isoform ratio	0	1.02
Eye	intron excision ratio	0	0.99
Eye	mRNA stability	0	0.8
IL	alternative polyA	0	0.93
IL	alternative TSS	0	0.94
IL	gene expression	0	0.9
IL	isoform ratio	0	0.91
IL	intron excision ratio	0	0.89
IL	mRNA stability	0	0.9
LHb	alternative polyA	0	0.88
LHb	alternative TSS	0	1.02
LHb	gene expression	0	0.88
LHb	isoform ratio	0	0.97
LHb	intron excision ratio	0	0.94
LHb	mRNA stability	0	0.98
Liver	alternative polyA	0	0.9
Liver	alternative TSS	0	0.9
Liver	gene expression	0	0.89
Liver	isoform ratio	0	0.89
Liver	intron excision ratio	0	0.88
Liver	mRNA stability	0	0.92
NAcc	alternative polyA	0	0.94
NAcc	alternative TSS	0	0.96
NAcc	gene expression	0	0.89
NAcc	isoform ratio	0	0.83
NAcc	intron excision ratio	0	0.92
NAcc	mRNA stability	0	0.89
OFC	alternative polyA	0	0.92
OFC	alternative TSS	0	0.98
OFC	gene expression	0	0.88
OFC	isoform ratio	0	0.9
OFC	intron excision ratio	0	0.95
OFC	mRNA stability	0	0.87
PL	alternative polyA	0	0.97
PL	alternative TSS	0	0.88
PL	gene expression	0	0.9
PL	isoform ratio	0	0.88
PL	intron excision ratio	0	0.9
PL	mRNA stability	0	0.89