Hub : Traits

Intermitt. access escalation Index

IntA_Inf_Z_Term / IntA_Inf_Z_D1

Tags: Behavior · Intermittent access · Cocaine

Project: p50_paul_meyer_2020

1 significantly associated model · 1 unique gene

Significant Loci

# chr p0 p1 # assoc genes # joint models best TWAS P best SNP P cond SNP P % var exp joint genes
1 7 51230254 52627618 1 1 1e-08 0.21 1.4e-39 -10996 Ptprb

p0: physical position of the start of the locus. p1: physical position of the end of the locus. # joint models: number of models selected by step-wise conditional analysis.

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
BMI with tail 2.9 1 0 0 0 1 Ptprb
BMI without tail 8.1 1 0 0 0 1 Ptprb
Body weight 2.1 1 0 0 0 1 Ptprb
Heart weight 7.4 1 0 0 0 1 Ptprb
Extensor digitorum longus weight 1.1 1 0 0 0 1 Ptprb
Reaction time omissions 3.4 1 0 0 0 1 Ptprb
Intermitt. access day 15 inactive lever presses 7.1 1 0 0 0 1 Ptprb
Baseline Anxiety 4.7 1 0 0 0 1 Ptprb
Progressive ratio test 1 inactive lever presses 4.9 1 0 0 0 1 Ptprb
Total sessions with >9 infusions 4.5 1 0 0 0 1 Ptprb
Short access day 1 total inactive lever presses 12.6 1 0 0 0 1 Ptprb
Short access day 10 total inactive lever presses 4.9 1 0 0 0 1 Ptprb
Short access day 10 total infusions 8.1 1 0 0 0 1 Ptprb
Short access total infusions 4.0 1 0 0 0 1 Ptprb
Compulsive drug intake 12.0 1 0 0 0 1 Ptprb
Number of responses in last shaping day 5.0 1 0 0 0 1 Ptprb
Active lever presses in extinction session 6 6.2 1 0 0 0 1 Ptprb
Sum of active levers in priming session hrs 5-6 6.8 1 0 0 0 1 Ptprb
Time to tail flick, test, after self-admin 7.4 1 0 0 0 1 Ptprb
Delay disc. indifference point, 0s delay 4.1 1 0 0 0 1 Ptprb
Delay disc. indifference point, 4s delay 7.0 1 0 0 0 1 Ptprb
Distance moved, locomotor task time 1 7.2 1 0 0 0 1 Ptprb
Vertical activity count, locomotor time 2 5.8 1 0 0 0 1 Ptprb
Run reversals in cocaine runway, females 6.3 1 0 0 0 1 Ptprb
Run reversals in cocaine runway, males 20.4 1 0 0 0 1 Ptprb
Latency to leave start box in cocaine runway 17.6 1 0 0 0 1 Ptprb
Latency to leave start box in cocaine runway, F 4.6 1 0 0 0 1 Ptprb
Latency to leave start box in cocaine runway, M 10.1 1 0 0 0 1 Ptprb
Rb content in liver 9.3 1 0 0 0 1 Ptprb

chisq ratio: Average Chi2 statistic for the selected genes in the secondary trait, divided by the average statistic for all genes in the secondary trait. # genes+: Shared significant genes at Bonferroni correction. # genes++: Shared significant genes at transcriptome-wide significance. % genes++: Number of [++] genes as a percentage of primary trait’s total joint genes. corr: Correlation of effect sizes across the [+] genes.

Associations by panel

tissue modality # hits % hits/tests avg chisq
Adipose alternative polyA 0 0.000 0.87
Adipose alternative TSS 0 0.000 0.88
Adipose gene expression 0 0.000 0.91
Adipose isoform ratio 1 0.035 0.89
Adipose intron excision ratio 0 0.000 0.92
Adipose mRNA stability 0 0.000 0.91
BLA alternative polyA 0 0.000 1.00
BLA alternative TSS 0 0.000 0.88
BLA gene expression 0 0.000 0.88
BLA isoform ratio 0 0.000 0.88
BLA intron excision ratio 0 0.000 0.93
BLA mRNA stability 0 0.000 0.86
Brain alternative polyA 0 0.000 0.91
Brain alternative TSS 0 0.000 0.90
Brain gene expression 0 0.000 0.88
Brain isoform ratio 0 0.000 0.88
Brain intron excision ratio 0 0.000 0.89
Brain mRNA stability 0 0.000 0.90
Eye alternative polyA 0 0.000 0.88
Eye alternative TSS 0 0.000 0.84
Eye gene expression 0 0.000 0.88
Eye isoform ratio 0 0.000 1.02
Eye intron excision ratio 0 0.000 0.99
Eye mRNA stability 0 0.000 0.80
IL alternative polyA 0 0.000 0.93
IL alternative TSS 0 0.000 0.94
IL gene expression 0 0.000 0.90
IL isoform ratio 0 0.000 0.91
IL intron excision ratio 0 0.000 0.89
IL mRNA stability 0 0.000 0.90
LHb alternative polyA 0 0.000 0.88
LHb alternative TSS 0 0.000 1.02
LHb gene expression 0 0.000 0.88
LHb isoform ratio 0 0.000 0.97
LHb intron excision ratio 0 0.000 0.94
LHb mRNA stability 0 0.000 0.98
Liver alternative polyA 0 0.000 0.90
Liver alternative TSS 0 0.000 0.90
Liver gene expression 0 0.000 0.89
Liver isoform ratio 0 0.000 0.89
Liver intron excision ratio 0 0.000 0.88
Liver mRNA stability 0 0.000 0.92
NAcc alternative polyA 0 0.000 0.94
NAcc alternative TSS 0 0.000 0.96
NAcc gene expression 0 0.000 0.89
NAcc isoform ratio 0 0.000 0.83
NAcc intron excision ratio 0 0.000 0.92
NAcc mRNA stability 0 0.000 0.89
OFC alternative polyA 0 0.000 0.92
OFC alternative TSS 0 0.000 0.98
OFC gene expression 0 0.000 0.88
OFC isoform ratio 0 0.000 0.90
OFC intron excision ratio 0 0.000 0.95
OFC mRNA stability 0 0.000 0.87
PL alternative polyA 0 0.000 0.97
PL alternative TSS 0 0.000 0.88
PL gene expression 0 0.000 0.90
PL isoform ratio 0 0.000 0.88
PL intron excision ratio 0 0.000 0.90
PL mRNA stability 0 0.000 0.89

avg chisq: Average Chi2 (squared Z-score) across all models in this panel for this trait.