Hub : Genes

Stim1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Adipose intron excision ratio chr1_156808342_156812201 0.04 0.03 7.1e-04 0.02 0.02 0.02 0.02 1.0e-03 4.7e-03 6.1e-03 4.6e-03
2 NAcc gene expression Stim1 0.04 0.02 7.8e-04 0.03 0.02 0.01 0.03 1.8e-04 6.8e-04 1.5e-02 5.4e-04
3 Liver gene expression Stim1 0.61 0.13 0.0e+00 0.27 0.43 0.43 0.43 3.0e-30 1.4e-51 5.4e-52 2.5e-52
4 Adipose intron excision ratio chr1_156808342_156810180 0.03 0.02 8.0e-03 0.01 0.01 0 0.01 9.1e-03 4.0e-02 8.7e-02 2.8e-02
5 PL mRNA stability Stim1 0.07 0.06 3.3e-04 0.03 0.04 0.03 0.03 2.5e-04 2.7e-05 6.4e-04 3.5e-04
6 NAcc mRNA stability Stim1 0.08 0.05 1.1e-07 0.07 0.07 0.06 0.08 7.9e-09 3.0e-08 2.8e-07 3.4e-09
7 LHb mRNA stability Stim1 0.26 0.14 2.5e-04 0.16 0.17 0.16 0.16 1.4e-04 9.3e-05 1.3e-04 1.1e-04
8 PL gene expression Stim1 0.04 0.03 8.8e-05 0.04 0.04 0.04 0.04 1.4e-05 6.4e-05 6.4e-05 3.6e-05
9 Brain gene expression Stim1 0.05 0.03 3.7e-05 0.05 0.04 0.03 0.04 3.7e-05 6.8e-05 5.1e-04 6.7e-05
10 NAcc intron excision ratio chr1_156805090_156807013 0.02 0.01 9.5e-03 0.02 0.01 0.01 0.01 3.3e-03 9.9e-03 1.9e-02 1.3e-02
11 Brain intron excision ratio chr1_156808342_156812201 0.03 0.02 2.4e-03 0.02 0.02 0.01 0.01 4.0e-03 9.7e-03 2.4e-02 1.9e-02
12 NAcc intron excision ratio chr1_156808342_156812201 0.02 0.02 6.7e-03 0.01 0.01 0.01 0.01 2.3e-02 1.1e-02 2.8e-02 2.0e-02
13 Brain intron excision ratio chr1_156810272_156812201 0.04 0.03 1.2e-03 0.02 0.03 0.02 0.03 2.6e-03 1.2e-03 6.0e-03 1.9e-03
14 Brain mRNA stability Stim1 0.15 0.07 2.2e-16 0.15 0.18 0.18 0.18 8.1e-14 1.4e-16 2.9e-16 1.8e-16

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14
Bone: apparent density0.10.10.3-0.40.6-0.60.5-0.1-0.0-0.10.30.30.30.3-0.10.5-0.1
Area under the delay curve0.60.72.0-0.90.8-1.20.90.91.41.0-0.3-0.3-0.2-0.30.8-0.40.8
BMI with tail1.24.07.4-1.10.70.41.1-1.5-1.5-1.92.72.72.52.6-2.12.3-2.6
BMI without tail0.40.82.61.5-1.31.4-1.6-0.6-1.2-0.7-0.1-0.1-0.3-0.1-0.5-0.2-0.5
Body weight0.31.12.01.4-1.20.7-1.30.80.10.6-1.1-1.1-1.2-1.10.8-1.40.8
Weight adjusted by age0.70.82.61.4-1.31.3-1.60.0-0.2-0.2-0.7-0.7-1.0-1.00.1-0.80.2
Bone surface0.40.71.31.0-1.00.5-0.90.00.20.2-1.1-1.1-1.1-1.10.4-0.80.8
Bone volume0.30.51.00.9-0.70.3-0.90.20.10.3-1.0-1.0-1.0-0.90.5-0.70.7
Breakpoint value in progressive ratio session0.91.01.9-0.60.9-0.10.5-1.0-1.0-0.81.01.01.31.4-1.11.2-1.1
Number of licking bursts1.51.75.5-2.02.3-2.31.41.40.91.10.90.90.80.70.80.40.2
Context. condit. distance diff. score1.82.25.72.0-2.02.4-1.7-1.9-2.0-1.7-0.4-0.4-0.10.0-1.40.3-0.9
Locomotion velocity, session 11.71.83.4-1.20.8-0.21.0-1.2-0.6-1.21.61.61.81.8-1.41.7-1.6
Locomotion distance, session 11.21.52.9-0.0-0.51.2-0.2-1.7-1.2-1.71.11.11.31.2-1.71.3-1.6
Locomotion velocity, session 21.21.42.3-0.8-0.00.60.8-1.4-0.8-1.41.21.21.51.5-1.51.4-1.5
Locomotion distance, session 21.21.72.90.1-0.31.0-0.4-1.6-1.5-1.61.41.41.51.4-1.71.4-1.7
Locomotion velocity, session 30.30.30.80.6-0.90.9-0.2-0.9-0.6-0.7-0.4-0.4-0.10.0-0.60.2-0.2
Locomotion distance, session 30.60.71.70.8-1.01.2-0.6-1.3-1.1-1.1-0.1-0.10.20.3-1.00.5-0.6
Stereotopy head waving bouts, day 30.60.71.5-0.2-0.1-0.40.21.01.21.0-0.8-0.8-0.9-1.01.1-1.01.0
Stereotopy head waving duration, day 30.10.10.40.3-0.60.60.1-0.5-0.0-0.50.20.20.10.1-0.40.2-0.3
Locomotion velocity, session 70.80.91.6-0.20.40.10.6-1.0-1.0-1.01.11.11.21.2-1.11.2-1.2
Locomotion distance, session 70.00.10.30.00.5-0.50.00.40.00.30.10.10.10.10.3-0.00.1
Stereotopy head waving bouts, day 71.21.44.31.6-2.12.1-1.1-1.5-0.8-1.3-0.6-0.6-0.5-0.4-0.90.0-0.3
Stereotopy head waving duration, day 71.31.64.91.7-2.22.2-1.3-1.7-0.9-1.5-0.5-0.5-0.4-0.2-1.20.2-0.6
Locomotion velocity, session 80.50.61.70.7-1.31.3-0.8-1.1-0.5-0.8-0.6-0.6-0.3-0.2-0.60.0-0.2
Locomotion distance, session 81.72.56.31.6-1.92.5-1.6-2.1-2.2-2.00.20.20.50.6-1.80.7-1.4
Degree of sensitization distance1.01.02.40.10.3-0.9-0.21.50.81.4-0.8-0.8-0.9-1.01.4-1.31.2
Degree of sensitization stereotypy2.52.78.12.3-2.82.8-1.7-2.1-1.3-1.7-0.9-0.9-0.7-0.4-1.30.1-0.6
Conditioned locomotion0.70.81.9-0.60.6-1.00.51.31.41.2-0.7-0.7-0.5-0.61.1-0.81.0
Cocaine response after cond. corrected0.70.72.2-1.51.2-1.21.30.81.00.70.50.50.40.30.50.10.1
Cocaine response after cond. not corrected0.60.71.5-1.20.9-0.51.2-0.10.2-0.21.01.00.90.9-0.40.8-0.7
Cocaine response before conditioning1.72.04.50.9-1.01.7-0.5-2.1-1.8-2.00.80.80.91.1-1.91.3-1.6
Saline control response2.12.85.21.7-2.01.1-1.60.51.10.7-2.3-2.3-2.1-2.11.1-1.91.5
Bone: connectivity density1.01.52.9-0.80.60.01.0-1.4-0.8-1.31.31.31.41.6-1.51.7-1.4
Bone: cortical apparent density0.81.12.8-0.91.2-1.50.81.70.91.5-0.3-0.3-0.3-0.51.4-0.81.0
Bone: cortical area0.30.50.90.7-0.60.2-0.70.40.60.4-0.9-0.9-0.8-0.90.6-0.90.7
Bone: cortical porosity0.10.10.30.3-0.30.0-0.30.00.50.2-0.5-0.5-0.6-0.60.3-0.30.5
Bone: cortical porosity0.20.20.50.3-0.40.0-0.20.10.60.2-0.5-0.5-0.7-0.70.3-0.40.5
Bone: cortical thickness0.30.50.9-0.70.6-0.30.8-0.30.1-0.40.90.91.00.8-0.50.8-0.7
Bone: cortical thickness0.00.00.00.1-0.10.0-0.10.00.10.00.00.0-0.0-0.00.0-0.10.0
Bone: cortical tissue density0.81.02.7-0.91.2-1.50.81.60.91.5-0.3-0.3-0.2-0.41.3-0.71.0
Condit. Reinf. active minus inactive responses1.61.83.21.0-1.10.4-1.31.01.21.0-1.5-1.5-1.7-1.81.3-1.71.5
Condit. Reinf. active-inactive response ratio3.03.25.81.4-1.30.3-1.81.41.41.5-2.1-2.1-2.4-2.41.8-2.22.0
Condit. Reinf. active responses1.01.22.20.3-0.4-0.3-0.31.21.51.2-1.1-1.1-1.4-1.41.3-1.41.4
Condit. Reinf. inactive responses0.20.31.1-0.90.6-0.61.00.20.20.10.50.50.50.50.00.3-0.2
Incentive salience index mean1.11.32.30.5-0.70.0-0.71.11.51.0-1.1-1.1-1.5-1.51.2-1.41.3
Condit. Reinf. lever presses0.10.10.5-0.00.1-0.20.40.30.70.20.10.1-0.2-0.20.3-0.20.3
Condit. Reinf. active minus inactive responses3.64.511.13.3-3.32.8-3.0-0.9-0.8-0.6-2.3-2.3-2.2-1.9-0.0-1.60.7
Condit. Reinf. active-inactive response ratio0.70.71.91.3-1.31.4-1.2-0.9-0.9-0.8-0.5-0.5-0.5-0.3-0.5-0.1-0.2
Condit. Reinf. active responses5.06.916.74.1-3.93.2-3.7-0.7-0.9-0.3-2.9-2.9-2.9-2.50.3-2.21.2
Condit. Reinf. inactive responses3.34.08.42.9-2.82.0-2.70.1-0.30.3-2.4-2.4-2.4-2.20.7-2.01.3
Condit. Reinf. lever presses6.89.226.15.1-4.94.7-4.6-2.3-2.4-1.9-2.1-2.1-2.2-1.7-1.2-1.3-0.1
Condit. Reinf. lever reinforcers received5.27.318.54.3-4.13.4-3.9-0.9-1.1-0.5-2.9-2.9-2.9-2.50.1-2.11.1
Conditioned reinforcement - actives0.20.20.60.2-0.30.4-0.3-0.8-0.1-0.60.10.10.50.2-0.60.4-0.4
Conditioned reinforcement - inactives0.80.92.2-0.30.5-0.90.31.51.21.3-0.6-0.6-0.8-0.91.3-1.01.1
Conditioned locomotion1.21.43.40.6-1.01.4-0.7-1.9-1.4-1.70.70.70.90.8-1.61.1-1.3
Patch foraging indifference point 0 sec1.32.16.22.5-2.22.1-2.4-1.3-1.5-1.2-0.5-0.5-0.6-0.2-0.9-0.1-0.5
Patch foraging indifference point AUC0.40.40.90.9-0.80.5-0.80.30.30.3-0.7-0.7-0.8-0.70.4-0.80.5
Delay disc. indifference point, 0s delay0.20.20.70.8-0.80.7-0.8-0.3-0.4-0.3-0.3-0.3-0.3-0.2-0.2-0.2-0.1
Delay disc. indifference point, 16s delay1.31.34.1-0.80.5-1.30.71.32.01.5-0.9-0.9-0.8-0.91.4-0.91.4
Delay disc. indifference point, 2s delay0.60.61.30.3-0.60.1-0.30.41.00.6-1.1-1.1-1.0-1.00.7-1.00.9
Delay disc. indifference point, 24s delay1.51.54.6-1.51.2-1.81.41.52.11.4-0.2-0.2-0.2-0.41.3-0.51.0
Delay disc. indifference point, 4s delay0.70.71.30.8-0.80.3-0.80.50.50.6-1.1-1.1-1.1-1.00.7-1.10.9
Delay disc. indifference point, 8s delay0.30.30.9-0.90.8-1.00.80.20.60.40.00.00.40.30.20.10.2
Indifference point function ln k0.20.30.60.5-0.10.5-0.6-0.7-0.8-0.70.30.30.30.3-0.60.5-0.5
Indifference point function log k0.20.30.60.5-0.10.5-0.6-0.7-0.8-0.70.30.30.30.3-0.60.5-0.5
Patch foraging total patch changes 0 sec1.11.95.32.3-2.02.0-2.3-1.4-1.5-1.2-0.3-0.3-0.30.0-1.00.0-0.7
Patch foraging total patch changes 12 sec0.70.92.51.6-1.41.0-1.3-0.10.10.1-1.1-1.1-1.1-0.80.2-0.90.5
Patch foraging total patch changes 18 sec0.40.51.71.1-1.31.1-0.9-0.6-0.2-0.5-0.6-0.6-0.5-0.2-0.3-0.3-0.1
Patch foraging total patch changes 24 sec0.91.12.81.6-1.71.2-1.60.10.20.1-1.0-1.0-1.3-1.00.3-1.10.5
Patch foraging total patch changes 6 sec0.60.83.11.6-1.81.4-1.5-0.6-0.7-0.7-0.1-0.1-0.5-0.3-0.4-0.2-0.3
Patch foraging time to switch 0 sec1.93.09.5-3.02.6-2.63.11.11.81.20.70.71.00.90.70.60.3
Patch foraging water rate 0 sec1.62.69.22.9-2.32.3-3.0-1.0-1.8-1.1-0.7-0.7-0.8-0.7-0.7-0.5-0.3
Patch foraging water rate 12 sec2.53.88.21.4-1.52.6-1.3-2.4-2.9-2.61.31.31.11.4-2.41.5-2.2
Patch foraging water rate 18 sec1.82.45.72.2-2.02.4-2.3-1.6-2.2-1.6-0.1-0.10.10.1-1.30.2-1.0
Patch foraging water rate 24 sec0.91.32.70.4-0.41.1-0.4-1.3-1.7-1.41.11.11.01.1-1.41.1-1.4
Patch foraging water rate 6 sec1.11.64.21.1-0.81.5-1.0-1.6-2.0-1.70.80.80.80.9-1.61.0-1.4
Seeking ratio, delayed vs. immediate footshock1.11.33.1-1.71.5-1.21.80.20.30.01.41.41.31.0-0.21.0-0.5
Distance traveled before self-admin0.50.51.1-0.60.8-0.40.7-0.2-0.1-0.41.01.00.91.1-0.50.9-0.7
Distance traveled after self-admin0.80.91.60.5-0.40.8-0.5-1.3-1.2-1.20.70.70.90.9-1.21.0-1.1
Extensor digitorum longus weight0.10.31.0-1.00.6-0.60.70.30.80.20.60.60.50.40.10.2-0.2
Bone: elastic displacement1.51.73.0-1.71.6-1.01.6-0.30.0-0.51.71.71.71.6-0.71.5-1.1
Bone: elastic work3.14.08.0-1.92.0-1.02.0-0.9-0.4-1.22.82.82.72.5-1.52.4-2.0
Bone: endosteal estimation1.22.54.31.9-1.50.7-1.90.70.20.9-2.1-2.1-2.0-1.91.2-1.91.6
Bone: endosteal perimeter1.22.65.12.1-1.81.1-2.30.40.20.5-2.0-2.0-2.0-1.90.9-1.71.3
Epididymis fat weight0.10.20.7-0.50.7-0.80.20.8-0.20.8-0.1-0.10.10.20.5-0.30.3
Delta time in closed arm before/after self-admin1.41.32.9-0.70.8-1.20.71.71.71.6-0.7-0.7-0.8-0.81.5-1.11.2
Delta time in open arm before/after self-admin1.71.73.91.9-2.01.4-1.8-0.1-0.3-0.0-1.5-1.5-1.6-1.30.3-1.10.7
Diff in mean of infusions in LGA sessions2.32.55.3-0.71.0-1.90.72.32.32.2-0.9-0.9-1.2-1.32.1-1.41.8
Delay discount exponential model param0.60.71.91.1-1.01.3-1.1-0.8-1.4-0.90.10.1-0.00.1-0.70.2-0.6
Extinction: sum of active levers before priming0.10.10.4-0.60.6-0.50.60.1-0.20.10.30.30.40.4-0.00.2-0.1
Active lever presses in extinction session 61.51.52.91.3-1.21.7-1.2-1.6-1.6-1.70.70.70.30.4-1.40.9-1.2
Bone: final force1.32.13.6-0.10.4-1.30.11.81.81.9-1.3-1.3-1.5-1.51.9-1.61.9
Bone: final moment1.11.72.90.10.1-1.0-0.01.61.51.7-1.3-1.3-1.4-1.51.7-1.51.7
Food consumed during 24 hour testing period1.31.64.11.8-1.82.0-1.5-1.7-1.5-1.5-0.2-0.2-0.1-0.0-1.20.3-0.7
Glucose0.71.01.60.20.10.50.4-1.2-1.0-1.21.11.11.21.1-1.31.2-1.2
Heart weight0.81.13.71.8-1.61.5-1.9-0.3-1.0-0.5-0.5-0.5-1.0-0.8-0.1-0.50.1
Delay discount hyperbolic model param0.50.51.70.9-0.81.1-0.8-0.7-1.3-0.90.30.30.20.2-0.70.3-0.7
Intermittent access intake day 1-15 change2.01.93.40.8-0.71.5-0.8-1.5-1.8-1.81.41.41.21.1-1.71.2-1.7
Intermittent access intake escalation1.91.83.10.7-0.51.3-0.7-1.4-1.7-1.71.51.51.41.0-1.61.3-1.7
Intermittent access intake escalation 20.40.40.8-0.10.40.20.1-0.3-0.7-0.60.90.90.90.7-0.60.6-0.8
Intermitt. access day 1 inactive lever presses1.21.34.0-0.51.2-1.40.52.01.01.6-0.3-0.3-0.7-0.81.6-1.01.2
Intermitt. access day 15 inactive lever presses0.40.41.71.2-0.80.9-1.30.3-0.4-0.1-0.1-0.1-0.6-0.80.2-0.50.2
Intermitt. access escalation Index0.40.40.9-0.0-0.1-0.10.10.80.90.7-0.6-0.6-0.6-0.90.8-0.80.7
Intermittent access day 1 total infusions0.60.71.80.9-0.90.5-1.1-0.10.40.3-1.3-1.3-0.7-0.90.3-0.80.7
Intermittent access day 15 total infusions0.30.30.80.8-0.80.8-0.9-0.6-0.3-0.5-0.2-0.20.2-0.2-0.40.0-0.2
Intermittent access terminal intake (last 3 days)0.20.20.60.7-0.60.6-0.8-0.5-0.3-0.3-0.5-0.50.1-0.2-0.2-0.20.0
Intermittent access total infusions0.10.20.50.4-0.40.3-0.6-0.30.10.0-0.7-0.7-0.1-0.40.0-0.30.3
Intermittent access day 1 locomotion0.20.20.7-0.20.0-0.40.20.40.80.5-0.6-0.6-0.5-0.60.5-0.40.7
Intermittent access day 15 total locomotion0.60.61.40.4-0.71.0-0.4-1.1-0.6-1.20.70.70.50.4-1.00.8-0.9
Intermittent access total locomotion0.10.10.40.4-0.70.7-0.4-0.6-0.1-0.4-0.1-0.10.0-0.2-0.30.1-0.1
Intermittent access standard deviation0.40.40.9-0.20.60.00.3-0.4-0.7-0.60.90.90.90.8-0.60.7-0.8
Left kidney weight0.51.33.71.9-1.91.8-1.9-0.3-0.6-0.4-0.6-0.6-1.2-0.8-0.1-0.80.1
Right kidney weight0.41.23.41.7-1.41.1-1.80.4-0.20.2-0.8-0.8-1.4-1.20.5-1.10.5
Cocaine induced anxiety1.92.24.9-1.81.8-2.21.92.11.81.9-0.0-0.0-0.3-0.41.7-0.61.2
Post-drug Anxiety2.22.44.50.10.1-1.00.12.11.82.0-1.5-1.5-1.5-1.82.1-1.82.0
Baseline Anxiety1.61.73.92.0-1.81.4-2.0-0.10.10.1-1.5-1.5-1.4-1.60.4-1.20.9
Tail length5.316.025.94.9-4.22.2-5.11.80.82.1-5.1-5.1-5.1-4.82.8-4.73.7
Length with tail3.211.719.33.6-2.91.2-3.72.41.22.5-4.3-4.3-4.4-4.33.0-4.33.5
Length without tail0.10.30.8-0.40.6-0.70.70.90.80.7-0.1-0.1-0.2-0.30.7-0.40.5
Times rat made contact with spout0.30.30.7-0.20.5-0.8-0.00.80.50.8-0.3-0.3-0.4-0.40.7-0.50.6
Lifetime Intake0.30.30.80.7-0.70.8-0.9-0.7-0.2-0.4-0.7-0.7-0.0-0.3-0.3-0.20.0
Liver weight, left2.84.48.1-1.51.5-2.61.72.62.72.8-1.7-1.7-1.3-1.52.6-1.82.4
Liver weight, right3.96.411.5-0.70.9-2.31.03.33.03.4-2.4-2.4-2.3-2.43.3-2.83.1
Locomotor activity0.30.51.01.0-0.91.0-0.7-0.7-1.0-0.80.20.20.20.2-0.70.2-0.6
Locomotor testing distance0.91.44.12.0-1.71.9-1.6-1.3-1.5-1.2-0.2-0.2-0.1-0.1-1.00.0-0.7
Locomotor testing rearing0.30.51.41.2-0.90.7-0.9-0.2-0.10.0-1.1-1.1-0.7-0.60.1-0.70.4
Locomotion in novel chamber1.11.42.9-0.70.8-0.00.8-0.8-0.6-1.11.71.71.51.3-1.21.5-1.4
Locomotion in novel chamber post-restriction0.60.72.10.3-0.61.0-0.3-1.4-0.9-1.30.50.50.50.6-1.20.9-0.9
Fecal boli incidents, locomotor time 10.80.92.9-1.41.5-1.71.40.80.80.90.10.10.50.20.60.10.5
Change in fecal boli incidents, locomotor task0.00.00.2-0.1-0.40.10.1-0.30.2-0.1-0.1-0.1-0.20.1-0.1-0.0-0.1
Time >=10cm from walls, locomotor time 10.40.40.80.7-0.90.7-0.7-0.10.60.0-0.7-0.7-0.7-0.80.2-0.50.4
Bouts of movement, locomotor time 10.91.02.30.3-0.60.1-0.31.21.40.9-0.7-0.7-1.5-1.51.2-1.11.2
Total resting periods, locomotor time 10.30.41.3-0.3-0.0-0.20.30.81.10.6-0.1-0.1-0.8-0.80.7-0.50.7
Rest time, locomotor task time 10.20.30.7-0.4-0.1-0.30.40.30.90.5-0.7-0.7-0.5-0.50.5-0.50.7
Distance moved, locomotor task time 10.00.00.10.30.00.2-0.3-0.1-0.1-0.20.20.20.30.2-0.20.2-0.3
Vertical activity count, locomotor time 10.10.10.20.30.1-0.2-0.30.40.00.3-0.2-0.2-0.2-0.20.3-0.30.2
Time >=10cm from walls, locomotor time 22.22.34.31.7-2.11.2-1.70.30.60.6-2.0-2.0-1.9-1.80.9-1.71.3
Bouts of movement, locomotor time 22.93.16.00.0-0.1-0.8-0.01.82.52.0-2.0-2.0-1.9-2.12.1-2.02.2
Total resting periods, locomotor time 22.42.56.2-0.50.3-1.20.51.72.52.0-1.6-1.6-1.4-1.61.9-1.61.9
Rest time, locomotor task time 21.61.85.2-2.32.1-1.72.30.40.80.41.01.01.41.2-0.00.9-0.4
Distance moved, locomotor task time 21.21.44.31.8-2.11.8-1.8-0.7-0.5-0.5-1.0-1.0-1.0-0.9-0.2-0.70.2
Vertical activity count, locomotor time 20.70.71.50.7-0.80.1-0.70.50.50.7-1.2-1.2-1.0-0.90.8-1.11.0
Light reinforcement 11.83.26.0-2.22.2-1.52.3-0.3-0.1-0.52.42.42.12.1-0.91.9-1.4
Light reinforcement 24.05.48.4-1.00.70.61.0-2.5-2.1-2.52.82.82.82.9-2.82.9-2.9
Bone: marrow area1.12.34.01.7-1.30.5-1.80.80.41.0-2.0-2.0-1.9-1.91.3-1.81.6
Bone: maximum diameter1.32.35.12.1-2.01.3-2.30.10.20.3-1.7-1.7-1.8-1.80.6-1.61.1
Bone: maximum force0.71.22.00.10.1-0.8-0.01.21.41.3-1.1-1.1-1.2-1.21.3-1.21.4
Bone: maximum moment0.40.71.20.3-0.1-0.5-0.20.81.00.9-0.9-0.9-1.0-1.01.0-1.01.1
Mean time between licks in bursts5.17.212.82.9-3.11.9-3.01.10.31.2-3.5-3.5-3.6-3.41.8-3.22.4
Mean num. licks in bursts1.31.54.42.0-2.12.0-1.6-1.0-0.8-0.8-1.0-1.0-0.9-0.9-0.5-0.50.1
Cd content in liver0.30.41.1-0.81.0-1.11.00.60.30.6-0.0-0.00.40.10.4-0.00.3
Co content in liver3.03.56.31.7-1.80.7-1.71.01.31.2-2.5-2.5-2.4-2.51.6-2.22.0
Cu content in liver1.61.93.31.4-1.20.4-1.20.81.10.9-1.8-1.8-1.8-1.81.2-1.71.5
Fe content in liver0.70.81.5-0.00.0-0.60.01.10.91.1-1.0-1.0-1.0-1.11.2-1.01.2
K content in liver0.40.31.2-0.70.8-0.80.80.71.10.60.20.20.1-0.10.5-0.10.2
Mg content in liver0.00.00.10.2-0.10.2-0.1-0.20.0-0.30.20.20.10.1-0.20.2-0.2
Mn content in liver1.61.93.7-1.81.9-1.31.9-0.30.3-0.41.51.51.71.6-0.71.5-1.0
Na content in liver0.10.10.40.2-0.50.4-0.3-0.60.5-0.5-0.1-0.1-0.1-0.1-0.40.3-0.1
Rb content in liver0.60.83.50.3-0.90.5-0.60.11.90.3-1.1-1.1-0.9-1.20.5-0.70.8
Se content in liver2.02.57.2-2.42.7-2.62.61.01.61.00.90.90.90.80.60.70.2
Sr content in liver2.32.13.6-0.0-0.11.0-0.1-1.8-1.7-1.81.51.51.41.7-1.91.6-1.9
Zn content in liver1.71.94.81.6-1.72.2-1.7-1.8-1.9-1.70.30.30.20.4-1.50.5-1.2
Bone: minimum diameter1.22.34.11.0-1.00.0-0.91.21.41.4-2.0-2.0-1.8-1.91.5-2.01.7
Time in familiar zone, hab. session 10.20.20.60.6-0.50.5-0.8-0.4-0.6-0.3-0.2-0.20.00.1-0.3-0.0-0.2
Time in novel zone, hab. session 10.50.50.9-0.30.4-0.70.51.00.90.9-0.5-0.5-0.5-0.60.9-0.60.8
Total zone transitions, hab. session 10.40.51.20.2-0.30.6-0.7-1.1-0.8-1.00.50.50.70.6-1.00.8-0.8
Total locomotion distance, hab. session 10.81.22.20.1-0.1-0.6-0.91.50.61.4-1.1-1.1-1.1-1.21.4-1.41.3
Locomotion velocity, hab. session 10.50.71.5-0.10.1-0.6-0.81.20.51.1-0.8-0.8-0.7-0.81.1-1.11.0
Time in familiar zone, hab. session 22.22.35.72.3-2.01.4-2.40.2-0.40.3-1.6-1.6-1.7-1.60.6-1.50.9
Time in novel zone, hab. session 22.32.34.1-1.71.4-0.51.5-0.9-0.6-1.11.91.92.01.9-1.31.9-1.6
Total zone transitions, hab. session 21.31.75.41.5-2.02.3-1.4-1.6-1.5-1.70.00.0-0.10.0-1.30.4-0.9
Total locomotion distance, hab. session 20.91.22.21.1-1.10.6-1.30.90.10.7-1.2-1.2-1.3-1.30.9-1.50.9
Locomotion velocity, hab. session 20.91.22.41.1-1.00.4-1.21.00.20.9-1.3-1.3-1.4-1.31.0-1.61.0
Novel to familiar place preference ratio2.62.74.60.4-0.4-0.3-0.21.81.01.8-1.9-1.9-2.0-2.12.0-2.12.1
Novelty place preference2.32.44.10.4-0.4-0.3-0.21.70.91.7-1.9-1.9-1.9-2.01.9-2.02.0
Time in novel zone, NPP test2.52.64.70.7-0.6-0.1-0.51.70.71.6-2.0-2.0-2.1-2.21.9-2.12.0
Total zone transitions, NPP test1.42.03.2-0.4-0.10.8-0.1-1.7-1.4-1.81.61.61.61.6-1.81.7-1.8
Total locomotion distance, NPP test0.10.20.4-0.50.3-0.2-0.20.2-0.4-0.00.70.70.60.5-0.20.2-0.5
Locomotion velocity, NPP test0.30.40.9-0.80.7-0.40.30.2-0.2-0.11.01.00.90.8-0.30.5-0.7
Intraocular pressure0.30.50.9-0.30.10.30.2-0.8-0.5-0.90.80.80.60.7-0.80.9-0.8
Delta distance traveled before/after self-admin1.31.42.81.6-1.61.1-1.6-0.2-0.20.1-1.7-1.7-1.2-1.40.3-1.10.8
Delta ambulatory time before/after self-admin0.80.92.11.4-1.41.2-1.4-0.6-0.4-0.3-1.2-1.2-0.7-1.0-0.1-0.60.4
Parametrial fat weight0.71.32.6-0.71.2-0.50.5-0.6-0.8-0.71.61.61.61.5-0.91.4-1.2
Pavlov. Cond. lever latency0.40.51.0-0.80.9-0.60.5-0.1-0.5-0.20.80.81.00.9-0.40.7-0.7
Pavlov. Cond. magazine entry latency1.21.54.12.0-2.02.0-1.9-0.9-0.7-0.8-1.0-1.0-0.9-0.8-0.4-0.60.0
Pavlov. Cond. change in total contacts1.11.22.41.0-1.20.6-0.30.30.70.5-1.5-1.5-1.5-1.50.8-1.21.2
Pavlov. Cond. index score0.81.02.81.6-1.71.5-1.1-0.7-0.1-0.4-1.0-1.0-1.0-0.9-0.1-0.60.3
Pavlov. Cond. latency score0.70.92.51.4-1.61.3-1.0-0.50.1-0.2-1.1-1.1-1.1-1.00.0-0.80.5
Pavlov. Cond. lever contacts0.30.30.80.8-0.90.7-0.4-0.10.3-0.0-0.6-0.6-0.8-0.70.2-0.50.4
Pavlov. Cond. magazine entry number1.01.33.7-1.81.9-1.91.51.00.60.80.80.80.80.70.50.40.0
Pavlov. Cond. intertrial magazine entries0.50.61.9-1.41.0-1.21.10.81.00.80.30.30.10.00.6-0.00.4
Pavlov. Cond. lever-magazine prob. diff.0.60.82.31.4-1.51.4-1.0-0.6-0.1-0.4-0.8-0.8-0.9-0.8-0.2-0.50.3
Pavlov. Cond. response bias0.40.41.31.1-1.11.0-0.8-0.4-0.2-0.3-0.6-0.6-0.7-0.6-0.1-0.40.2
Pavlov. Cond. lever latency7.810.528.8-5.35.2-5.44.83.03.12.71.71.71.61.11.90.70.9
Pavlov. Cond. magazine entry latency4.65.312.92.5-2.13.0-2.4-2.9-3.6-2.91.01.01.11.3-2.71.4-2.3
Pavlov. Cond. change in total contacts6.99.526.44.9-4.95.1-4.2-3.1-3.3-2.8-1.4-1.4-1.3-0.9-2.1-0.4-1.1
Pavlov. Cond. index score6.48.322.84.5-4.34.8-4.1-3.1-3.3-2.8-0.9-0.9-0.8-0.4-2.2-0.0-1.4
Pavlov. Cond. latency score6.27.720.84.2-4.04.6-3.8-3.2-3.3-3.0-0.5-0.5-0.4-0.1-2.40.3-1.6
Pavlov. Cond. lever contacts7.910.829.55.4-5.35.4-4.9-2.9-2.9-2.6-1.9-1.9-1.9-1.4-1.8-0.9-0.7
Pavlov. Cond. magazine entry number4.96.014.9-3.23.0-3.92.93.13.33.0-0.3-0.3-0.3-0.62.6-0.92.0
Pavlov. Cond. intertrial magazine entries1.52.03.30.2-0.5-0.4-0.21.41.41.5-1.7-1.7-1.8-1.81.7-1.81.8
Pavlov. Cond. lever-magazine prob. diff.6.38.021.94.5-4.34.7-4.1-2.9-3.2-2.7-1.0-1.0-0.9-0.5-2.1-0.1-1.3
Pavlov. Cond. response bias8.611.731.65.5-5.35.6-5.1-3.3-3.5-3.0-1.5-1.5-1.4-1.0-2.2-0.5-1.2
Time in closed arm before self-admin1.61.84.41.3-1.52.1-1.2-1.9-1.8-1.80.40.40.50.3-1.60.8-1.3
Time in closed arm after self-admin0.20.20.7-0.70.8-0.70.70.50.70.40.20.20.20.00.30.00.2
Time in open arm before self-admin2.42.67.7-2.32.8-2.52.21.41.11.01.51.51.01.10.70.7-0.0
Time in open arm after self-admin0.30.40.80.3-0.2-0.2-0.30.80.30.7-0.6-0.6-0.9-0.60.8-0.80.7
Bone: periosteal estimation0.71.52.51.4-1.20.5-1.40.60.50.7-1.6-1.6-1.5-1.60.9-1.41.2
Bone: periosteal perimeter0.71.22.61.5-1.41.0-1.60.10.20.2-1.4-1.4-1.2-1.20.4-1.10.7
Bone: post-yield work0.10.10.20.4-0.30.4-0.4-0.3-0.4-0.2-0.2-0.2-0.1-0.1-0.2-0.0-0.0
Progressive ratio test 1 active lever presses0.00.00.10.00.00.0-0.1-0.10.3-0.0-0.2-0.20.1-0.20.0-0.00.1
Progressive ratio test 1 breakpoint0.00.00.10.00.0-0.0-0.10.00.30.1-0.4-0.4-0.0-0.30.1-0.20.2
Progressive ratio test 1 inactive lever presses0.00.00.10.0-0.00.0-0.20.10.20.1-0.2-0.2-0.2-0.20.2-0.20.2
Progressive ratio test 2 active lever presses0.30.30.90.0-0.3-0.1-0.10.10.70.4-1.0-1.0-0.4-0.60.4-0.50.7
Progressive ratio test 2 breakpoint0.30.41.10.2-0.4-0.0-0.30.20.70.5-1.0-1.0-0.6-0.80.5-0.60.8
Progressive ratio test 2 inactive lever presses0.00.00.10.2-0.20.2-0.3-0.10.2-0.0-0.2-0.2-0.0-0.30.0-0.10.1
Incentive Sensitization - Responses0.40.41.30.6-0.70.3-0.7-0.00.20.3-1.1-1.1-0.7-0.70.4-0.70.7
Incentive Sensitization - Breakpoint0.20.20.60.5-0.60.3-0.6-0.3-0.00.1-0.8-0.8-0.3-0.40.1-0.40.4
Sum of active levers in priming session hrs 5-60.40.31.20.2-0.00.5-0.2-0.7-1.1-0.70.40.40.50.6-0.70.5-0.7
Progressive ratio0.40.50.8-0.0-0.40.50.0-0.8-0.7-0.90.90.90.50.7-0.90.8-0.9
Food seeking constrained by brief footshock1.21.53.31.5-1.81.3-1.50.30.10.3-1.3-1.3-1.7-1.50.6-1.40.8
Seeking ratio, punishment vs. effort0.91.12.51.0-0.70.4-0.90.60.30.8-1.6-1.6-1.3-1.20.9-1.41.1
Retroperitoneal fat weight0.62.15.4-1.31.8-2.11.32.31.32.1-0.4-0.4-0.2-0.41.8-1.11.2
Reaction time number correct0.20.30.5-0.20.10.30.4-0.6-0.3-0.60.70.70.60.6-0.70.7-0.7
Reaction time mean minus median0.20.30.80.8-0.90.4-0.50.2-0.00.2-0.7-0.7-0.5-0.60.3-0.70.4
Reaction time mean minus median AUC0.10.20.70.6-0.80.4-0.3-0.2-0.2-0.0-0.5-0.5-0.1-0.3-0.0-0.40.1
Reaction time num false alarms2.02.77.8-2.21.8-2.31.91.92.81.9-0.2-0.2-0.3-0.51.6-0.71.2
Reaction time num false alarms AUC1.62.25.8-2.31.9-2.22.01.62.41.6-0.0-0.00.0-0.11.2-0.30.9
Reaction time trials correct on left0.20.30.5-0.20.10.30.4-0.6-0.3-0.60.70.70.60.6-0.70.7-0.7
Reaction time trials on left0.30.40.6-0.30.20.30.5-0.6-0.3-0.70.80.80.70.7-0.70.7-0.8
Reaction time mean1.41.94.5-1.21.4-2.11.32.01.42.0-0.7-0.7-0.3-0.61.7-1.01.4
Reaction time mean AUC1.52.15.1-1.51.6-2.31.52.01.62.0-0.6-0.6-0.2-0.51.7-0.91.4
Median of all reaction times1.72.36.4-1.72.0-2.51.62.11.52.1-0.4-0.4-0.1-0.31.7-0.71.3
Reaction time omissions0.50.72.0-1.41.3-1.11.40.20.20.20.50.51.00.9-0.10.5-0.3
Reaction time false alarm rate1.42.04.8-2.01.8-2.21.71.62.21.6-0.1-0.10.0-0.21.3-0.40.9
Reaction time premature initiation rate1.11.43.01.7-1.71.0-1.50.2-0.00.3-1.5-1.5-1.3-1.20.5-1.40.8
Reaction time premature initiations0.40.51.71.1-1.31.0-0.9-0.2-0.3-0.2-0.8-0.8-0.5-0.5-0.0-0.60.1
Std. dev. reaction times1.11.62.7-0.0-0.0-0.90.21.51.41.6-1.5-1.5-1.1-1.31.6-1.51.6
Reaction time trials completed0.30.40.6-0.30.20.30.5-0.6-0.3-0.70.80.80.70.7-0.70.7-0.8
Reaction time trials AUC0.10.20.3-0.20.10.30.3-0.4-0.2-0.50.60.60.50.5-0.50.5-0.6
Run reversals in cocaine runway, females0.20.20.50.6-0.70.5-0.60.2-0.20.1-0.5-0.5-0.5-0.40.2-0.60.2
Run reversals in cocaine runway, males0.20.20.6-0.80.4-0.80.80.40.70.30.40.40.10.20.20.20.1
Latency to leave start box in cocaine runway0.50.62.3-1.01.3-1.51.00.60.40.80.00.00.50.50.40.10.3
Latency to leave start box in cocaine runway, F0.70.82.2-0.61.0-1.50.61.20.91.3-0.6-0.6-0.3-0.31.1-0.70.9
Latency to leave start box in cocaine runway, M0.80.81.5-1.21.1-0.81.2-0.5-0.1-0.30.70.71.21.1-0.61.0-0.6
Std. dev. time between licks in bursts2.22.74.51.6-1.20.4-1.71.30.21.3-2.1-2.1-2.1-2.01.6-2.11.7
Total sessions with >9 infusions1.92.16.31.0-1.41.9-1.0-2.5-1.8-2.00.20.21.10.9-2.01.1-1.4
Short access day 1 total inactive lever presses0.70.81.9-0.20.5-0.90.11.40.91.2-0.6-0.6-0.8-0.91.3-0.91.1
Short access day 10 total inactive lever presses0.30.30.8-0.80.9-0.90.60.80.20.50.50.50.20.20.40.00.1
Short access day 1 total infusions0.60.61.41.1-1.21.0-1.2-0.8-0.3-0.4-1.1-1.1-0.4-0.4-0.3-0.40.2
Short access day 10 total infusions0.40.51.31.0-1.00.9-1.2-0.6-0.2-0.3-0.8-0.8-0.2-0.5-0.2-0.40.2
Short access total infusions0.50.51.61.1-1.11.1-1.3-0.7-0.5-0.4-0.8-0.8-0.2-0.5-0.3-0.30.0
Short access day 1 locomotion1.21.32.50.4-0.31.0-0.6-1.6-1.5-1.50.90.91.20.9-1.41.2-1.3
Short access day 10 total locomotion0.40.40.7-0.30.30.10.4-0.7-0.7-0.60.60.60.90.8-0.70.7-0.7
Short access total locomotion0.20.20.6-0.50.30.00.4-0.7-0.4-0.50.40.40.80.5-0.60.6-0.5
One hour access (0.3 mA shock)0.60.71.60.7-0.70.9-0.7-1.3-1.2-1.10.20.20.60.7-1.10.6-0.9
Compulsive drug intake0.20.20.9-0.30.2-0.20.30.0-0.3-0.30.90.90.40.5-0.30.6-0.5
One hour access (shock baseline)0.30.30.80.9-0.70.7-0.9-0.6-0.5-0.3-0.7-0.7-0.1-0.1-0.3-0.2-0.0
Social response proportion0.20.31.0-0.50.2-0.40.31.00.80.60.10.1-0.4-0.40.6-0.40.3
Social responses0.70.92.1-0.30.3-0.90.11.41.21.3-0.7-0.7-0.8-0.81.2-1.11.0
Social time1.41.95.8-2.32.1-1.82.40.31.10.41.01.01.21.1-0.00.9-0.3
Soleus weight0.41.22.6-0.40.3-0.90.31.61.41.5-0.9-0.9-1.0-1.01.5-1.31.2
Bone: stiffness2.84.47.4-0.10.3-1.6-0.22.62.52.7-2.1-2.1-2.2-2.32.7-2.42.7
Tibialis anterior weight0.20.51.00.4-0.4-0.0-0.40.70.80.7-0.9-0.9-0.9-0.90.8-1.00.8
Time to tail flick, vehicle, before self-admin0.20.21.01.0-0.60.7-0.9-0.0-0.4-0.3-0.2-0.2-0.2-0.6-0.0-0.2-0.0
Time to tail flick, vehicle, after self-admin0.60.71.61.2-1.11.2-1.2-0.9-0.8-0.7-0.7-0.7-0.8-0.3-0.5-0.1-0.0
Time to tail flick, test, before self-admin1.71.63.61.8-1.81.2-1.90.2-0.30.2-1.3-1.3-1.7-1.50.5-1.20.9
Time to tail flick, test, after self-admin3.53.66.61.8-2.10.9-1.91.31.01.2-2.1-2.1-2.6-2.61.7-2.31.9
Delta time to tail flick, vehicle, before/after SA0.20.20.80.2-0.20.4-0.2-0.9-0.6-0.60.00.00.00.5-0.60.4-0.4
Delta time to tail flick, test, before/after SA0.10.10.3-0.40.2-0.30.30.50.40.30.20.20.0-0.10.3-0.20.1
Tibia length0.20.61.61.0-1.21.0-1.2-0.60.1-0.4-0.7-0.7-0.7-0.7-0.1-0.30.3
Ambulatory time before self-admin0.60.61.2-1.01.1-0.70.9-0.1-0.1-0.20.90.90.90.9-0.40.8-0.6
Ambulatory time after self-admin0.40.41.10.5-0.40.7-0.5-1.1-0.9-0.90.10.10.50.3-0.80.6-0.6
Bone: tissue strength2.52.54.0-0.60.60.20.6-1.5-1.6-1.62.02.01.91.9-1.82.0-1.9
Total heroin consumption0.60.71.51.0-0.71.2-1.0-1.0-1.2-1.00.30.30.30.4-0.90.4-0.8
Bone: trabecular number0.81.33.0-1.61.5-1.11.7-0.40.1-0.41.21.21.31.4-0.71.4-0.8
Bone: trabecular spacing1.01.32.40.7-0.81.4-0.6-1.4-1.5-1.51.01.00.90.9-1.40.9-1.3
Bone: trabecular thickness1.82.23.80.60.0-0.9-0.61.70.91.8-1.8-1.8-1.7-1.71.9-1.72.0
Bone: trabecular tissue density4.56.311.2-0.30.6-2.10.13.32.83.4-2.5-2.5-2.3-2.63.3-2.93.2
Water consumed over 24 hours0.20.20.9-0.50.9-0.90.50.40.20.30.50.50.40.30.20.30.0
Number of responses in last shaping day1.01.12.3-0.20.2-0.80.30.91.51.2-1.4-1.4-0.9-1.01.1-1.11.3