Gab2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 BLA gene expression Gab2 0.09 0.07 1.2e-03 0.03 0.03 0.03 0.03 1.6e-02 1.1e-02 9.1e-03 1.5e-02
2 Brain mRNA stability Gab2 0.04 0.03 4.2e-04 0.02 0.03 0.03 0.03 2.5e-03 9.5e-04 1.6e-03 2.0e-03
3 Adipose mRNA stability Gab2 0.1 0.06 1.3e-07 0.01 0.06 0.05 0.05 1.3e-02 3.7e-07 2.0e-06 6.8e-06
4 NAcc gene expression Gab2 0.03 0.02 8.4e-03 0.01 0.01 0 0.01 2.4e-02 5.9e-03 7.4e-02 1.1e-02
5 Adipose gene expression Gab2 0.05 0.03 1.8e-04 0.02 0.03 0.02 0.02 5.4e-03 5.3e-04 2.4e-03 1.6e-03
6 IL gene expression Gab2 0.28 0.13 3.9e-04 0.09 0.14 0.12 0.12 4.5e-03 2.9e-04 9.1e-04 9.8e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6
Bone: apparent density0.10.20.50.3-0.50.1-0.6-0.00.7
Area under the delay curve0.50.51.1-1.1-0.8-0.5-0.7-0.30.7
BMI with tail1.13.76.1-0.32.52.12.22.3-1.2
BMI without tail5.611.520.2-0.14.52.94.43.2-3.3
Body weight2.811.719.7-0.74.43.54.13.9-2.5
Weight adjusted by age0.81.02.9-0.30.7-0.51.4-0.4-1.7
Bone surface0.61.12.3-1.1-1.1-1.5-0.4-1.3-0.1
Bone volume0.30.51.3-1.2-0.5-0.9-0.0-0.7-0.3
Breakpoint value in progressive ratio session0.30.30.60.2-0.7-0.5-0.7-0.60.5
Number of licking bursts1.51.73.51.31.41.90.71.60.0
Context. condit. distance diff. score2.63.26.1-1.0-2.1-2.5-1.4-2.30.3
Locomotion velocity, session 11.41.52.5-0.2-1.6-1.2-1.5-1.30.9
Locomotion distance, session 10.50.71.4-0.4-1.0-1.1-0.7-1.20.0
Locomotion velocity, session 20.40.40.9-0.8-0.6-1.0-0.2-0.8-0.1
Locomotion distance, session 20.10.20.5-0.60.40.50.20.70.1
Locomotion velocity, session 30.20.30.4-0.4-0.7-0.6-0.5-0.60.3
Locomotion distance, session 31.92.13.4-0.9-1.8-1.8-1.4-1.70.7
Stereotopy head waving bouts, day 31.61.94.82.21.51.31.11.0-0.6
Stereotopy head waving duration, day 30.50.61.40.00.41.1-0.11.20.8
Locomotion velocity, session 70.30.30.5-0.4-0.7-0.6-0.5-0.60.3
Locomotion distance, session 70.40.51.0-0.9-0.5-1.00.0-0.9-0.5
Stereotopy head waving bouts, day 70.50.50.90.7-0.8-0.8-0.7-0.90.3
Stereotopy head waving duration, day 70.10.20.3-0.3-0.5-0.5-0.4-0.50.2
Locomotion velocity, session 84.35.27.9-2.5-2.8-2.3-2.3-1.91.7
Locomotion distance, session 81.01.42.3-1.2-1.4-1.5-0.9-1.30.4
Degree of sensitization distance1.71.73.3-0.11.60.71.80.7-1.7
Degree of sensitization stereotypy2.22.44.1-0.2-1.9-2.0-1.4-2.00.6
Conditioned locomotion0.40.41.1-0.5-0.20.6-0.60.71.1
Cocaine response after cond. corrected0.20.20.60.1-0.0-0.50.3-0.6-0.8
Cocaine response after cond. not corrected0.40.41.20.5-0.5-0.9-0.2-1.1-0.4
Cocaine response before conditioning0.60.81.81.4-0.8-0.5-0.9-0.80.6
Saline control response1.11.44.2-2.01.00.81.01.2-0.5
Bone: connectivity density1.01.62.80.4-1.7-1.3-1.5-1.50.9
Bone: cortical apparent density0.40.51.2-0.10.81.00.41.10.1
Bone: cortical area0.30.51.1-1.00.4-0.30.8-0.2-1.0
Bone: cortical porosity0.20.20.40.7-0.4-0.2-0.5-0.40.3
Bone: cortical porosity0.30.41.11.0-0.5-0.5-0.5-0.70.1
Bone: cortical thickness0.00.10.20.20.30.20.40.1-0.4
Bone: cortical thickness1.11.33.1-0.4-1.0-1.7-0.3-1.8-0.7
Bone: cortical tissue density0.30.51.1-0.10.71.00.41.00.1
Condit. Reinf. active minus inactive responses1.11.32.2-0.81.30.71.50.9-1.3
Condit. Reinf. active-inactive response ratio1.21.32.2-0.71.41.01.51.1-1.1
Condit. Reinf. active responses0.70.81.3-0.41.20.81.10.9-0.9
Condit. Reinf. inactive responses0.00.00.00.10.0-0.00.0-0.0-0.0
Incentive salience index mean0.50.61.3-0.80.7-0.01.10.1-1.1
Condit. Reinf. lever presses0.30.40.8-0.9-0.7-0.9-0.3-0.8-0.0
Condit. Reinf. active minus inactive responses1.72.18.1-2.80.1-1.11.0-0.6-1.4
Condit. Reinf. active-inactive response ratio0.91.04.1-2.0-0.4-0.90.2-0.6-0.5
Condit. Reinf. active responses2.33.211.1-3.30.6-0.91.6-0.3-2.0
Condit. Reinf. inactive responses1.41.73.1-1.61.30.21.80.6-1.6
Condit. Reinf. lever presses3.14.221.1-4.6-1.1-1.6-0.2-0.7-0.0
Condit. Reinf. lever reinforcers received2.33.211.6-3.40.3-1.31.4-0.6-1.9
Conditioned reinforcement - actives4.74.710.20.4-2.5-3.0-1.6-3.20.1
Conditioned reinforcement - inactives0.30.31.11.0-0.4-0.4-0.3-0.60.1
Conditioned locomotion3.64.38.50.5-2.5-2.7-1.7-2.90.6
Patch foraging indifference point 0 sec0.50.84.7-2.20.1-0.20.30.3-0.2
Patch foraging indifference point AUC0.10.20.4-0.50.1-0.40.4-0.3-0.6
Delay disc. indifference point, 0s delay0.50.61.20.0-0.2-1.10.4-1.1-1.0
Delay disc. indifference point, 16s delay0.90.91.9-1.3-0.60.2-1.00.51.4
Delay disc. indifference point, 2s delay0.40.41.0-0.3-0.8-1.0-0.4-0.90.1
Delay disc. indifference point, 24s delay0.60.61.2-0.9-0.10.7-0.60.81.1
Delay disc. indifference point, 4s delay0.40.41.5-1.2-0.2-0.70.3-0.4-0.4
Delay disc. indifference point, 8s delay0.70.71.7-1.3-0.9-0.6-0.8-0.30.7
Indifference point function ln k0.40.61.6-0.7-0.70.1-1.00.31.3
Indifference point function log k0.40.61.6-0.7-0.70.1-1.00.31.3
Patch foraging total patch changes 0 sec0.50.84.6-2.1-0.0-0.20.20.2-0.1
Patch foraging total patch changes 12 sec0.50.71.8-0.40.2-0.90.8-0.8-1.3
Patch foraging total patch changes 18 sec0.81.02.9-1.70.2-0.80.8-0.5-1.2
Patch foraging total patch changes 24 sec0.70.92.3-0.70.2-1.00.9-0.9-1.5
Patch foraging total patch changes 6 sec0.30.51.0-0.90.20.8-0.11.00.7
Patch foraging time to switch 0 sec1.01.57.32.70.61.0-0.00.50.2
Patch foraging water rate 0 sec0.81.23.8-2.0-0.9-1.3-0.3-1.0-0.1
Patch foraging water rate 12 sec0.71.04.8-2.2-0.6-0.3-0.50.10.8
Patch foraging water rate 18 sec0.50.63.4-1.80.2-0.00.30.4-0.1
Patch foraging water rate 24 sec0.91.22.2-1.5-1.1-0.4-1.2-0.11.4
Patch foraging water rate 6 sec0.50.71.1-1.1-1.0-0.5-1.0-0.31.0
Seeking ratio, delayed vs. immediate footshock0.30.30.90.9-0.3-0.5-0.1-0.8-0.3
Distance traveled before self-admin0.10.10.10.20.20.40.10.30.1
Distance traveled after self-admin0.70.71.21.00.11.1-0.60.91.1
Extensor digitorum longus weight0.41.72.3-1.51.41.21.41.5-0.7
Bone: elastic displacement0.20.30.70.4-0.20.5-0.60.40.8
Bone: elastic work0.81.12.90.4-1.00.2-1.50.01.7
Bone: endosteal estimation0.51.12.4-1.60.3-0.91.1-0.6-1.4
Bone: endosteal perimeter0.71.55.7-2.4-0.3-1.30.5-0.7-0.8
Epididymis fat weight2.25.110.11.22.81.23.21.1-2.9
Delta time in closed arm before/after self-admin2.82.86.6-2.61.41.51.12.1-0.2
Delta time in open arm before/after self-admin0.80.71.8-0.3-0.5-1.30.2-1.3-0.8
Diff in mean of infusions in LGA sessions1.71.94.50.91.22.10.42.00.7
Delay discount exponential model param0.50.51.21.10.70.40.70.2-0.7
Extinction: sum of active levers before priming0.20.20.6-0.80.30.10.50.3-0.4
Active lever presses in extinction session 60.90.91.80.5-1.0-1.2-0.7-1.40.0
Bone: final force0.10.20.4-0.4-0.6-0.4-0.6-0.40.4
Bone: final moment0.10.20.3-0.4-0.6-0.4-0.5-0.40.3
Food consumed during 24 hour testing period1.21.52.5-0.6-1.6-1.4-1.3-1.21.0
Glucose0.20.30.6-0.8-0.6-0.3-0.5-0.10.7
Heart weight0.40.61.7-1.3-0.5-1.0-0.0-0.8-0.4
Delay discount hyperbolic model param0.40.51.11.00.80.60.60.4-0.5
Intermittent access intake day 1-15 change1.51.52.4-0.7-1.6-1.4-1.2-1.40.7
Intermittent access intake escalation1.61.52.4-1.0-1.5-1.5-1.1-1.40.6
Intermittent access intake escalation 20.60.61.40.2-0.6-1.1-0.2-1.2-0.4
Intermitt. access day 1 inactive lever presses0.70.83.41.80.1-0.50.2-0.8-0.7
Intermitt. access day 15 inactive lever presses0.00.00.10.3-0.10.0-0.20.00.3
Intermitt. access escalation Index0.40.30.50.60.10.7-0.30.70.7
Intermittent access day 1 total infusions0.40.51.1-0.7-0.7-1.0-0.1-0.9-0.2
Intermittent access day 15 total infusions2.22.54.4-0.8-2.0-2.1-1.3-2.00.6
Intermittent access terminal intake (last 3 days)1.31.53.3-0.1-1.4-1.8-0.7-1.80.0
Intermittent access total infusions1.41.53.70.2-1.2-1.9-0.5-1.9-0.3
Intermittent access day 1 locomotion1.41.52.71.1-1.4-1.4-1.0-1.60.4
Intermittent access day 15 total locomotion1.01.02.3-0.4-1.1-1.5-0.5-1.5-0.1
Intermittent access total locomotion0.80.92.20.4-0.9-1.4-0.3-1.5-0.3
Intermittent access standard deviation0.40.40.80.8-0.2-0.80.2-0.9-0.7
Left kidney weight0.92.75.6-1.21.80.42.40.8-2.2
Right kidney weight0.92.44.7-0.91.90.82.21.1-1.8
Cocaine induced anxiety0.60.71.60.80.71.30.11.10.5
Post-drug Anxiety0.30.30.6-0.50.50.70.20.80.1
Baseline Anxiety1.11.13.3-1.8-0.9-1.3-0.3-1.0-0.1
Tail length3.09.218.7-1.33.71.54.32.0-3.8
Length with tail2.17.913.2-0.83.62.43.62.8-2.5
Length without tail0.40.91.9-0.10.31.3-0.31.41.2
Times rat made contact with spout0.70.81.30.71.10.90.91.0-0.4
Lifetime Intake1.51.74.1-0.0-1.3-2.0-0.5-2.0-0.4
Liver weight, left0.91.52.40.11.61.41.31.5-0.6
Liver weight, right3.55.89.32.03.02.42.82.2-1.8
Locomotor activity0.81.32.5-0.71.41.31.01.6-0.4
Locomotor testing distance1.11.83.3-1.81.40.31.60.7-1.6
Locomotor testing rearing2.23.46.3-0.92.31.02.51.3-2.2
Locomotion in novel chamber2.02.44.30.3-2.1-1.5-1.8-1.61.4
Locomotion in novel chamber post-restriction3.13.86.5-1.1-2.6-1.9-2.3-1.71.8
Fecal boli incidents, locomotor time 13.74.19.3-0.5-2.1-3.0-1.1-3.0-0.5
Change in fecal boli incidents, locomotor task2.12.04.90.41.12.20.12.11.0
Time >=10cm from walls, locomotor time 11.01.11.9-0.5-1.4-1.0-1.2-1.00.9
Bouts of movement, locomotor time 10.50.52.1-1.4-0.00.4-0.20.70.7
Total resting periods, locomotor time 10.60.71.4-1.2-0.40.3-0.70.61.2
Rest time, locomotor task time 10.60.71.2-0.9-0.9-0.3-1.1-0.21.1
Distance moved, locomotor task time 10.91.02.7-0.21.0-0.11.5-0.0-1.6
Vertical activity count, locomotor time 10.50.51.1-0.20.80.11.10.2-1.0
Time >=10cm from walls, locomotor time 20.60.61.3-0.6-0.5-1.20.1-1.1-0.6
Bouts of movement, locomotor time 20.10.10.1-0.30.30.10.40.2-0.3
Total resting periods, locomotor time 20.00.00.1-0.20.1-0.10.20.0-0.2
Rest time, locomotor task time 20.40.41.91.4-0.00.4-0.50.10.4
Distance moved, locomotor task time 21.11.32.6-0.80.0-1.41.0-1.2-1.6
Vertical activity count, locomotor time 21.01.12.8-0.70.5-0.81.3-0.6-1.7
Light reinforcement 10.81.42.21.51.41.21.01.0-0.7
Light reinforcement 20.20.21.11.0-0.2-0.0-0.2-0.30.0
Bone: marrow area0.51.02.0-1.40.3-0.81.0-0.5-1.4
Bone: maximum diameter0.50.93.9-2.0-0.1-0.80.6-0.4-0.7
Bone: maximum force0.40.71.3-0.7-1.1-0.6-1.0-0.60.9
Bone: maximum moment0.40.71.2-0.7-1.1-0.7-0.9-0.60.8
Mean time between licks in bursts1.52.15.5-1.10.5-1.41.7-1.1-2.3
Mean num. licks in bursts0.91.12.4-1.2-1.0-1.6-0.4-1.3-0.1
Cd content in liver0.30.40.60.30.80.60.70.5-0.6
Co content in liver0.80.91.7-1.30.0-1.00.8-0.7-1.2
Cu content in liver1.21.52.6-1.41.30.31.60.6-1.5
Fe content in liver0.70.82.10.1-0.6-1.3-0.0-1.4-0.7
K content in liver0.40.40.80.90.70.70.40.6-0.1
Mg content in liver0.00.00.1-0.20.1-0.00.10.1-0.1
Mn content in liver0.80.92.41.6-0.70.0-1.1-0.31.1
Na content in liver1.11.23.41.8-0.9-0.9-0.7-1.30.1
Rb content in liver0.70.93.8-2.00.50.50.50.9-0.0
Se content in liver0.81.05.62.4-0.00.4-0.4-0.10.3
Sr content in liver0.60.50.8-0.5-0.9-0.9-0.7-0.80.4
Zn content in liver0.70.82.4-1.50.1-0.80.7-0.5-1.0
Bone: minimum diameter0.81.43.3-1.21.0-0.21.70.1-1.8
Time in familiar zone, hab. session 10.10.00.10.1-0.2-0.3-0.1-0.3-0.0
Time in novel zone, hab. session 10.80.81.4-0.41.11.10.91.2-0.5
Total zone transitions, hab. session 10.81.12.9-0.0-0.31.1-1.11.11.7
Total locomotion distance, hab. session 13.75.27.82.62.82.12.41.7-2.0
Locomotion velocity, hab. session 13.14.37.22.72.51.72.21.3-1.9
Time in familiar zone, hab. session 20.30.31.5-1.20.1-0.10.30.3-0.1
Time in novel zone, hab. session 20.30.30.80.4-0.4-0.7-0.1-0.9-0.4
Total zone transitions, hab. session 20.60.81.7-0.7-0.20.9-0.81.01.3
Total locomotion distance, hab. session 22.93.96.61.32.61.92.31.7-1.8
Locomotion velocity, hab. session 23.44.68.01.22.82.22.42.1-1.8
Novel to familiar place preference ratio0.10.10.20.30.20.50.00.40.2
Novelty place preference0.00.00.10.00.20.30.10.30.1
Time in novel zone, NPP test0.00.10.1-0.30.00.3-0.10.30.2
Total zone transitions, NPP test0.50.81.5-0.8-1.0-0.2-1.2-0.11.2
Total locomotion distance, NPP test1.92.65.01.91.70.61.90.1-2.2
Locomotion velocity, NPP test2.33.25.52.41.90.72.00.2-2.3
Intraocular pressure2.63.65.6-2.0-2.4-2.0-1.9-1.71.4
Delta distance traveled before/after self-admin0.50.51.10.20.31.1-0.31.00.8
Delta ambulatory time before/after self-admin0.80.92.2-0.1-0.11.1-0.81.21.5
Parametrial fat weight1.73.25.60.42.22.41.72.3-0.7
Pavlov. Cond. lever latency0.50.61.20.80.71.10.21.00.3
Pavlov. Cond. magazine entry latency0.50.61.8-1.4-0.1-0.80.5-0.6-0.9
Pavlov. Cond. change in total contacts1.41.53.7-0.3-1.0-1.8-0.0-1.9-0.9
Pavlov. Cond. index score0.81.02.1-1.5-0.2-1.20.6-1.0-1.1
Pavlov. Cond. latency score0.70.91.4-1.2-0.3-1.20.5-1.0-1.0
Pavlov. Cond. lever contacts0.50.61.2-0.9-0.4-1.10.3-1.0-0.8
Pavlov. Cond. magazine entry number0.60.83.11.70.20.8-0.40.50.8
Pavlov. Cond. intertrial magazine entries0.30.31.51.20.40.40.20.2-0.2
Pavlov. Cond. lever-magazine prob. diff.0.70.91.5-1.2-0.4-1.20.4-1.0-0.9
Pavlov. Cond. response bias0.40.50.9-0.9-0.0-0.70.5-0.6-0.9
Pavlov. Cond. lever latency4.56.027.95.31.52.10.61.1-0.1
Pavlov. Cond. magazine entry latency2.52.98.5-2.9-1.7-1.5-1.3-1.10.9
Pavlov. Cond. change in total contacts2.63.617.0-4.1-1.1-1.6-0.3-0.9-0.1
Pavlov. Cond. index score4.05.120.6-4.5-1.7-2.1-0.8-1.30.2
Pavlov. Cond. latency score3.94.819.0-4.4-1.8-2.0-1.0-1.20.5
Pavlov. Cond. lever contacts3.95.427.2-5.2-1.2-1.7-0.4-0.70.1
Pavlov. Cond. magazine entry number5.16.216.64.12.52.81.52.1-0.7
Pavlov. Cond. intertrial magazine entries2.33.05.50.72.21.02.41.0-2.2
Pavlov. Cond. lever-magazine prob. diff.3.74.719.2-4.4-1.6-2.1-0.7-1.30.1
Pavlov. Cond. response bias4.66.325.9-5.1-1.7-2.5-0.6-1.5-0.1
Time in closed arm before self-admin0.70.81.50.3-1.1-0.6-1.2-0.81.0
Time in closed arm after self-admin1.31.42.9-0.6-1.4-0.4-1.7-0.31.7
Time in open arm before self-admin0.70.81.60.41.11.30.71.2-0.2
Time in open arm after self-admin0.60.71.50.21.00.31.20.4-1.1
Bone: periosteal estimation0.71.53.2-1.8-0.0-1.31.0-0.9-1.5
Bone: periosteal perimeter0.71.15.5-2.30.4-0.00.70.5-0.4
Bone: post-yield work0.20.30.70.1-0.6-0.1-0.7-0.10.8
Progressive ratio test 1 active lever presses0.20.20.50.7-0.5-0.3-0.5-0.50.3
Progressive ratio test 1 breakpoint0.40.41.01.0-0.5-0.5-0.5-0.70.2
Progressive ratio test 1 inactive lever presses0.20.20.40.4-0.2-0.60.0-0.7-0.4
Progressive ratio test 2 active lever presses1.21.33.2-0.4-0.7-1.80.3-1.7-1.0
Progressive ratio test 2 breakpoint0.91.12.4-0.2-0.5-1.60.4-1.5-1.1
Progressive ratio test 2 inactive lever presses0.60.71.8-0.0-0.6-1.30.0-1.3-0.6
Incentive Sensitization - Responses1.11.12.1-0.8-0.3-1.50.7-1.3-1.2
Incentive Sensitization - Breakpoint1.01.02.2-0.7-0.4-1.50.6-1.3-1.1
Sum of active levers in priming session hrs 5-60.40.40.70.40.70.80.50.8-0.1
Progressive ratio1.01.21.7-1.3-1.3-0.9-1.3-0.71.0
Food seeking constrained by brief footshock1.01.32.4-1.61.10.31.30.6-1.3
Seeking ratio, punishment vs. effort2.02.55.00.81.90.62.20.5-2.2
Retroperitoneal fat weight5.518.232.10.95.74.15.34.3-3.6
Reaction time number correct0.40.51.20.3-0.00.8-0.70.81.1
Reaction time mean minus median0.40.61.5-1.20.70.40.70.7-0.5
Reaction time mean minus median AUC0.20.21.1-1.00.20.30.20.50.1
Reaction time num false alarms0.40.50.90.40.90.90.70.8-0.4
Reaction time num false alarms AUC0.00.00.10.30.20.10.10.1-0.1
Reaction time trials correct on left0.40.51.20.3-0.00.8-0.70.81.1
Reaction time trials on left0.30.51.10.3-0.00.8-0.70.71.1
Reaction time mean0.30.40.60.40.80.60.70.4-0.6
Reaction time mean AUC0.10.20.30.50.50.50.40.3-0.3
Median of all reaction times0.20.20.80.90.30.20.3-0.1-0.5
Reaction time omissions0.40.50.7-0.80.80.50.80.5-0.7
Reaction time false alarm rate0.10.10.30.40.1-0.30.4-0.4-0.6
Reaction time premature initiation rate2.43.26.7-0.52.20.82.61.0-2.4
Reaction time premature initiations1.31.93.4-0.41.80.91.81.1-1.6
Std. dev. reaction times0.81.11.8-1.01.20.61.40.8-1.2
Reaction time trials completed0.30.51.10.3-0.00.8-0.70.71.1
Reaction time trials AUC0.30.40.80.20.20.9-0.50.90.8
Run reversals in cocaine runway, females3.23.15.5-1.42.11.12.31.5-1.9
Run reversals in cocaine runway, males1.11.12.2-1.5-1.1-0.5-1.2-0.21.3
Latency to leave start box in cocaine runway0.70.83.01.70.70.40.6-0.0-0.8
Latency to leave start box in cocaine runway, F1.11.22.71.50.7-0.21.0-0.6-1.6
Latency to leave start box in cocaine runway, M0.60.62.01.4-0.30.4-0.70.10.8
Std. dev. time between licks in bursts1.51.83.8-0.21.60.42.00.6-1.9
Total sessions with >9 infusions1.21.43.20.1-1.2-1.7-0.7-1.8-0.2
Short access day 1 total inactive lever presses0.20.20.5-0.1-0.6-0.7-0.3-0.70.0
Short access day 10 total inactive lever presses0.91.02.21.01.01.50.51.40.2
Short access day 1 total infusions1.31.43.5-0.0-0.9-1.8-0.0-1.9-1.0
Short access day 10 total infusions1.41.53.6-0.4-0.9-1.9-0.1-1.9-0.9
Short access total infusions1.21.43.40.2-0.8-1.8-0.1-1.9-0.9
Short access day 1 locomotion2.32.54.1-0.3-2.0-2.0-1.5-2.00.7
Short access day 10 total locomotion0.10.10.30.1-0.3-0.60.0-0.6-0.2
Short access total locomotion1.11.12.31.4-0.8-1.2-0.5-1.5-0.3
One hour access (0.3 mA shock)1.31.53.4-0.9-0.6-1.80.4-1.7-1.2
Compulsive drug intake0.10.10.30.5-0.1-0.3-0.0-0.5-0.3
One hour access (shock baseline)0.60.71.6-0.8-0.7-1.3-0.1-1.1-0.4
Social response proportion1.11.23.41.81.21.00.80.7-0.6
Social responses2.02.64.60.42.11.81.81.8-1.1
Social time0.70.93.01.70.91.00.40.6-0.3
Soleus weight1.02.94.8-0.62.21.52.21.7-1.5
Bone: stiffness0.10.10.5-0.0-0.30.3-0.50.20.7
Tibialis anterior weight0.31.11.8-0.51.31.21.11.3-0.5
Time to tail flick, vehicle, before self-admin0.60.61.10.01.01.00.71.0-0.3
Time to tail flick, vehicle, after self-admin0.80.92.3-1.5-1.0-0.9-0.8-0.50.6
Time to tail flick, test, before self-admin0.30.31.0-1.0-0.4-0.5-0.1-0.40.0
Time to tail flick, test, after self-admin0.70.72.7-1.60.2-0.60.7-0.2-0.9
Delta time to tail flick, vehicle, before/after SA2.22.23.6-1.0-1.9-1.7-1.5-1.60.9
Delta time to tail flick, test, before/after SA0.10.10.10.20.40.40.20.3-0.2
Tibia length0.51.52.9-0.6-1.5-1.7-1.0-1.60.3
Ambulatory time before self-admin0.20.20.30.2-0.5-0.1-0.5-0.20.6
Ambulatory time after self-admin1.01.13.20.7-0.50.9-1.20.71.8
Bone: tissue strength1.81.73.61.8-0.90.6-1.50.21.9
Total heroin consumption0.10.10.2-0.40.00.3-0.20.40.5
Bone: trabecular number0.40.61.40.7-0.70.1-1.1-0.11.2
Bone: trabecular spacing0.40.51.2-0.3-0.4-1.10.0-1.1-0.7
Bone: trabecular thickness1.21.53.2-1.41.11.50.71.80.2
Bone: trabecular tissue density2.84.07.70.12.52.61.72.8-0.5
Water consumed over 24 hours0.50.61.21.00.51.1-0.11.00.6
Number of responses in last shaping day1.92.05.91.10.8-0.91.6-1.1-2.4