Gab2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	BLA	gene expression	Gab2	0.09	0.06	1.6e-03	0.04	0.05	0.02	0.04	2.3e-03	1.7e-03	2.0e-02	3.1e-03
2	IC	gene expression	Gab2	0.11	0.06	4.3e-04	0.06	0.07	0.07	0.08	1.6e-03	4.6e-04	5.4e-04	4.0e-04
3	NAcc	gene expression	Gab2	0.04	0.02	8.4e-05	0.02	0.03	0.03	0.03	1.8e-04	1.6e-05	1.5e-05	3.7e-05
4	Brain	mRNA stability	Gab2	0.04	0.03	6.1e-04	0.03	0.03	0.03	0.03	1.3e-03	7.8e-04	9.0e-04	1.9e-03
5	Adipose	mRNA stability	Gab2	0.1	0.06	2.8e-08	0.01	0.07	0.06	0.05	8.3e-03	7.2e-08	9.2e-07	2.2e-06
6	pVTA	gene expression	Gab2	0.07	0.04	5.1e-04	0.04	0.04	0.05	0.04	8.0e-04	1.4e-04	9.1e-05	2.5e-04
7	Adipose	gene expression	Gab2	0.05	0.03	2.2e-04	0.02	0.03	0.02	0.02	2.7e-03	4.1e-04	1.2e-03	1.1e-03
8	IL	gene expression	Gab2	0.31	0.14	1.5e-04	0.1	0.14	0.09	0.12	2.0e-03	2.6e-04	4.5e-03	8.9e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6	7	8
Bone: apparent density	0.2	0.3	0.8	-0.5	-0.7	-0.2	-0.3	0.2	-0.9	0.1	0.6
Area under the delay curve	0.4	0.5	1.0	1.0	0.9	-0.8	-0.8	-0.6	-0.0	-0.5	0.6
BMI with tail	1.7	5.8	12.7	0.2	-0.5	3.1	3.6	2.1	2.3	2.2	-3.1
BMI without tail	2.6	7.8	16.4	0.7	-0.2	3.7	4.0	2.3	2.8	2.5	-3.5
Body weight	2.4	10.6	24.1	0.4	-0.9	4.0	4.9	3.5	2.5	3.7	-3.5
Weight adjusted by age	0.4	0.6	1.7	0.0	-0.5	1.3	0.5	-0.4	0.6	-0.5	-1.3
Bone surface	0.6	1.1	2.1	1.2	1.2	-0.5	-1.0	-1.5	0.9	-1.3	-0.1
Bone volume	0.3	0.5	1.1	1.0	0.9	-0.1	-0.3	-0.8	0.8	-0.6	-0.3
Breakpoint value in progressive ratio session	0.4	0.5	1.7	-0.8	-0.7	-0.3	-0.5	0.3	-1.3	0.1	1.0
Number of licking bursts	1.1	1.9	3.7	-1.4	-1.8	0.7	1.5	1.9	-0.4	1.8	-0.2
Context. condit. distance diff. score	2.5	3.0	6.0	1.2	1.7	-1.6	-2.2	-2.5	0.7	-2.4	0.5
Locomotion velocity, session 1	1.0	1.1	2.5	0.1	0.7	-1.3	-1.6	-1.1	-0.7	-1.2	1.1
Locomotion distance, session 1	0.5	0.6	1.3	0.4	0.7	-0.4	-1.0	-1.1	0.5	-1.2	0.1
Locomotion velocity, session 2	0.5	0.5	1.2	0.8	1.1	-0.2	-0.5	-1.0	0.7	-0.8	-0.2
Locomotion distance, session 2	0.2	0.2	0.5	0.6	0.7	-0.2	0.5	0.5	0.4	0.6	0.0
Locomotion velocity, session 3	0.2	0.2	0.4	0.4	0.6	-0.5	-0.6	-0.6	-0.1	-0.5	0.3
Locomotion distance, session 3	1.6	1.7	3.6	0.8	1.1	-1.2	-1.9	-1.7	-0.3	-1.7	0.9
Stereotopy head waving bouts, day 3	1.9	2.2	4.7	-2.2	-2.0	1.5	1.5	1.4	-0.5	1.2	-0.7
Stereotopy head waving duration, day 3	0.4	0.5	1.5	-0.1	-0.3	-0.4	0.6	1.2	-0.7	1.2	0.6
Locomotion velocity, session 7	0.2	0.3	0.6	0.2	0.1	-0.6	-0.8	-0.6	-0.1	-0.7	0.4
Locomotion distance, session 7	0.5	0.6	1.2	0.8	0.7	-0.3	-0.7	-1.1	0.8	-1.0	-0.3
Stereotopy head waving bouts, day 7	0.5	0.5	1.0	-0.4	-0.0	-0.8	-1.0	-0.8	-0.6	-0.9	0.7
Stereotopy head waving duration, day 7	0.1	0.2	0.3	0.3	0.4	-0.5	-0.5	-0.5	-0.1	-0.5	0.3
Locomotion velocity, session 8	4.4	5.2	8.2	2.4	2.9	-2.9	-2.8	-2.3	-0.0	-2.0	1.8
Locomotion distance, session 8	1.2	1.8	3.2	1.3	1.8	-1.5	-1.4	-1.5	0.7	-1.4	0.5
Degree of sensitization distance	1.3	1.3	3.0	0.2	-0.2	1.4	1.5	0.6	1.6	0.6	-1.7
Degree of sensitization stereotypy	1.7	1.8	4.0	0.3	0.8	-1.2	-2.0	-2.0	-0.2	-2.0	0.7
Conditioned locomotion	0.4	0.4	1.1	0.3	0.4	-1.0	-0.1	0.6	-0.5	0.7	1.0
Cocaine response after cond. corrected	0.2	0.2	0.5	0.0	-0.2	0.3	-0.1	-0.6	0.6	-0.7	-0.7
Cocaine response after cond. not corrected	0.3	0.4	1.3	-0.3	-0.3	-0.0	-0.7	-1.0	0.4	-1.1	-0.3
Cocaine response before conditioning	0.7	0.8	1.9	-1.4	-1.0	-0.2	-1.0	-0.6	-1.1	-0.8	0.7
Saline control response	0.8	1.1	3.0	1.7	1.3	-0.1	0.9	0.9	1.2	1.2	-0.3
Bone: connectivity density	0.7	1.0	2.3	-0.5	-0.4	-0.8	-1.5	-1.2	-0.9	-1.3	0.9
Bone: cortical apparent density	0.2	0.3	0.9	-0.1	0.0	-0.4	0.6	0.9	-0.1	1.0	0.2
Bone: cortical area	0.4	0.6	1.9	0.9	0.5	0.8	0.5	-0.2	1.4	-0.1	-1.1
Bone: cortical porosity	0.3	0.3	0.6	-0.8	-0.8	0.1	-0.5	-0.3	-0.6	-0.5	0.3
Bone: cortical porosity	0.3	0.4	0.9	-1.0	-0.8	0.2	-0.6	-0.4	-0.7	-0.6	0.3
Bone: cortical thickness	0.1	0.1	0.3	-0.3	-0.6	0.5	0.4	0.2	0.3	0.2	-0.4
Bone: cortical thickness	0.9	1.0	2.5	0.4	0.5	0.4	-0.7	-1.5	1.3	-1.6	-0.9
Bone: cortical tissue density	0.2	0.3	0.8	-0.2	-0.0	-0.5	0.5	0.9	-0.2	0.9	0.3
Condit. Reinf. active minus inactive responses	1.0	1.1	2.8	0.7	0.0	1.7	1.3	0.7	1.0	0.8	-1.3
Condit. Reinf. active-inactive response ratio	1.0	1.0	2.3	0.6	-0.2	1.5	1.4	0.9	0.8	1.0	-1.1
Condit. Reinf. active responses	0.5	0.6	1.4	0.3	-0.2	1.2	1.1	0.8	0.5	0.8	-0.9
Condit. Reinf. inactive responses	0.0	0.0	0.0	-0.1	0.0	-0.2	0.0	-0.0	-0.2	-0.0	-0.0
Incentive salience index mean	0.5	0.6	2.0	0.7	0.2	1.4	0.6	-0.1	0.8	0.0	-1.1
Condit. Reinf. lever presses	0.3	0.4	0.9	0.7	0.6	0.1	-0.7	-0.9	-0.1	-0.9	-0.1
Condit. Reinf. active minus inactive responses	2.4	3.1	8.5	2.9	2.4	0.3	0.1	-1.1	2.5	-0.7	-1.4
Condit. Reinf. active-inactive response ratio	1.1	1.3	4.0	2.0	1.6	0.0	-0.3	-0.9	1.5	-0.6	-0.6
Condit. Reinf. active responses	3.2	4.5	12.0	3.5	2.9	0.6	0.5	-1.0	3.2	-0.5	-1.9
Condit. Reinf. inactive responses	1.3	1.6	3.9	1.6	1.4	1.0	1.1	0.1	2.0	0.4	-1.5
Condit. Reinf. lever presses	5.4	7.4	24.4	4.9	4.5	-1.8	-1.0	-1.6	2.8	-0.9	-0.1
Condit. Reinf. lever reinforcers received	3.5	4.9	12.8	3.6	3.1	0.5	0.3	-1.3	3.3	-0.8	-1.8
Conditioned reinforcement - actives	0.8	1.4	3.8	0.0	0.5	-0.6	-1.6	-1.9	-0.2	-1.9	0.4
Conditioned reinforcement - inactives	0.6	0.8	1.8	-1.2	-0.9	-0.6	-0.7	0.0	-1.3	-0.1	1.3
Conditioned locomotion	2.4	3.1	7.4	-0.3	0.1	-1.2	-2.7	-2.6	-0.8	-2.7	1.2
Patch foraging indifference point 0 sec	0.7	1.2	4.3	2.1	1.9	-0.6	0.0	-0.2	1.3	0.1	-0.1
Patch foraging indifference point AUC	0.2	0.3	0.6	0.6	0.6	0.6	0.1	-0.5	0.8	-0.4	-0.7
Delay disc. indifference point, 0s delay	1.2	1.3	2.6	0.3	0.6	0.9	-0.5	-1.6	1.5	-1.6	-1.1
Delay disc. indifference point, 16s delay	0.9	1.0	3.0	1.3	1.1	-1.7	-0.5	0.3	-0.3	0.5	1.2
Delay disc. indifference point, 2s delay	0.4	0.4	1.2	0.4	0.5	-0.2	-0.8	-1.1	0.2	-1.0	0.1
Delay disc. indifference point, 24s delay	0.6	0.7	1.3	0.6	0.1	-0.9	0.1	1.0	-0.9	1.1	1.0
Delay disc. indifference point, 4s delay	0.9	0.9	2.0	1.4	1.3	0.3	-0.3	-1.1	1.2	-0.8	-0.6
Delay disc. indifference point, 8s delay	0.5	0.6	1.4	1.2	1.1	-1.0	-0.8	-0.5	-0.0	-0.3	0.7
Indifference point function ln k	0.4	0.7	2.6	0.6	0.7	-1.6	-0.6	0.2	-0.5	0.3	1.3
Indifference point function log k	0.4	0.7	2.6	0.6	0.7	-1.6	-0.6	0.2	-0.5	0.3	1.3
Patch foraging total patch changes 0 sec	0.7	1.3	4.4	2.1	1.9	-0.7	-0.1	-0.2	1.3	0.1	-0.0
Patch foraging total patch changes 12 sec	0.6	0.8	1.7	0.5	0.6	1.0	0.1	-0.9	1.3	-0.8	-1.3
Patch foraging total patch changes 18 sec	1.1	1.6	3.7	1.7	1.7	0.6	0.2	-0.9	1.9	-0.7	-1.3
Patch foraging total patch changes 24 sec	0.6	1.1	2.2	0.6	0.8	1.2	0.2	-1.0	1.4	-0.9	-1.5
Patch foraging total patch changes 6 sec	0.2	0.4	0.8	0.9	0.4	-0.5	0.2	0.7	0.0	0.9	0.5
Patch foraging time to switch 0 sec	1.3	2.6	8.1	-2.8	-2.7	0.9	0.5	1.0	-1.8	0.6	0.2
Patch foraging water rate 0 sec	0.9	1.8	4.5	2.1	2.1	-0.8	-0.9	-1.3	1.2	-1.0	-0.1
Patch foraging water rate 12 sec	0.6	1.3	4.0	2.0	1.9	-1.4	-0.5	-0.3	0.3	0.0	0.7
Patch foraging water rate 18 sec	0.7	1.1	3.6	1.9	1.7	-0.5	0.3	0.0	1.3	0.4	-0.1
Patch foraging water rate 24 sec	1.0	1.5	3.9	1.5	1.7	-2.0	-0.9	-0.3	0.0	-0.0	1.4
Patch foraging water rate 6 sec	0.5	0.8	1.9	1.0	1.1	-1.4	-0.9	-0.5	-0.1	-0.3	0.9
Seeking ratio, delayed vs. immediate footshock	0.6	0.7	1.8	-1.2	-1.3	0.8	-0.3	-0.7	-0.2	-0.9	-0.4
Distance traveled before self-admin	0.2	0.2	0.5	-0.3	-0.5	0.3	0.4	0.7	-0.5	0.7	0.1
Distance traveled after self-admin	1.2	1.5	3.8	-1.8	-1.9	0.2	-0.0	0.9	-1.6	0.6	1.0
Extensor digitorum longus weight	0.4	1.8	3.1	1.5	0.8	0.6	1.8	1.3	1.6	1.6	-1.1
Bone: elastic displacement	0.2	0.3	0.6	-0.4	-0.5	-0.3	-0.2	0.5	-0.8	0.4	0.8
Bone: elastic work	0.6	0.7	2.4	-0.4	-0.4	-1.1	-0.8	0.3	-1.1	0.2	1.6
Bone: endosteal estimation	0.7	1.6	3.3	1.7	1.5	1.0	0.3	-0.9	1.8	-0.6	-1.5
Bone: endosteal perimeter	1.1	2.4	6.4	2.5	2.5	0.0	-0.1	-1.1	1.9	-0.7	-1.0
Epididymis fat weight	0.7	2.5	4.7	-1.3	-1.5	2.1	2.2	1.6	0.4	1.5	-1.5
Delta time in closed arm before/after self-admin	2.1	2.0	4.6	2.1	1.8	-0.6	1.2	1.3	1.3	1.6	-0.2
Delta time in open arm before/after self-admin	0.6	0.6	1.3	0.9	1.0	0.4	-0.5	-1.1	0.5	-1.0	-0.5
Diff in mean of infusions in LGA sessions	2.7	3.2	5.5	-1.9	-2.1	-0.1	0.9	2.3	-2.3	2.1	1.3
Delay discount exponential model param	0.5	0.5	1.0	-1.0	-0.8	0.9	0.8	0.5	0.1	0.4	-0.7
Extinction: sum of active levers before priming	0.5	0.5	1.2	1.1	1.0	-0.1	0.7	0.6	0.6	0.8	-0.3
Active lever presses in extinction session 6	0.6	0.6	1.3	-0.7	-0.3	-0.8	-1.0	-0.4	-0.9	-0.5	1.2
Bone: final force	0.1	0.2	0.5	0.3	0.1	-0.6	-0.7	-0.5	0.2	-0.5	0.4
Bone: final moment	0.1	0.2	0.4	0.3	0.1	-0.5	-0.6	-0.5	0.2	-0.5	0.3
Food consumed during 24 hour testing period	1.0	1.4	2.3	0.5	1.4	-1.2	-1.5	-1.4	-0.6	-1.2	1.0
Glucose	0.1	0.2	0.5	0.7	0.5	-0.1	-0.1	-0.4	0.5	-0.3	-0.2
Heart weight	0.5	0.7	2.1	1.5	1.2	-0.7	0.4	0.5	0.9	0.7	0.0
Delay discount hyperbolic model param	0.4	0.5	1.1	-1.0	-0.8	0.7	0.7	0.7	-0.1	0.6	-0.4
Intermittent access intake day 1-15 change	0.5	1.0	3.0	0.8	1.1	-1.7	-1.2	-0.8	-0.0	-0.7	1.0
Intermittent access intake escalation	0.6	1.3	2.9	0.8	1.1	-1.7	-1.5	-1.2	-0.1	-1.1	1.0
Intermittent access intake escalation 2	0.6	0.7	2.0	-0.2	0.2	-0.6	-1.1	-1.4	0.2	-1.4	0.1
Intermitt. access day 1 inactive lever presses	0.3	1.0	4.1	-2.0	-1.6	0.4	-0.5	-0.3	-0.8	-0.6	0.4
Intermitt. access day 15 inactive lever presses	0.5	1.1	2.3	-1.5	-1.5	0.1	0.3	1.2	-1.1	1.0	0.8
Intermitt. access escalation Index	0.4	0.6	1.8	-0.5	-0.3	-0.9	-0.7	0.0	-1.3	-0.1	1.1
Intermittent access day 1 total infusions	0.4	0.6	1.2	0.9	0.9	-1.1	-0.8	-0.6	-0.2	-0.5	0.7
Intermittent access day 15 total infusions	1.5	2.3	4.1	0.9	1.3	-2.0	-2.0	-1.7	-0.6	-1.6	1.4
Intermittent access terminal intake (last 3 days)	1.0	1.3	2.7	0.3	0.8	-1.1	-1.5	-1.6	-0.2	-1.6	0.6
Intermittent access total infusions	0.8	0.9	2.4	0.3	0.7	-0.6	-1.3	-1.5	-0.2	-1.5	0.3
Intermittent access day 1 locomotion	0.6	0.8	1.5	-0.2	0.0	-1.1	-1.2	-0.7	-0.9	-0.7	1.2
Intermittent access day 15 total locomotion	0.4	0.8	1.6	-0.1	0.2	-1.1	-1.3	-1.0	-0.5	-1.0	0.9
Intermittent access total locomotion	0.3	0.4	0.8	-0.3	0.0	-0.7	-0.9	-0.8	-0.5	-0.8	0.6
Intermittent access standard deviation	0.2	0.4	1.0	0.2	0.2	0.8	0.9	0.2	0.8	0.3	-1.0
Left kidney weight	0.9	4.2	9.0	0.3	0.2	2.7	3.0	1.6	2.2	1.8	-2.6
Right kidney weight	1.0	4.5	8.8	0.3	0.1	2.9	3.0	1.3	2.4	1.5	-2.9
Cocaine induced anxiety	0.7	1.0	2.0	-1.1	-1.2	0.2	0.9	1.4	-0.7	1.3	0.2
Post-drug Anxiety	0.8	0.8	2.8	0.2	-0.2	-0.4	0.9	1.6	-0.4	1.7	0.5
Baseline Anxiety	0.9	1.0	3.4	1.8	1.7	-0.9	-0.3	-0.2	0.8	0.0	0.3
Tail length	1.3	5.2	10.6	1.4	0.5	2.7	3.3	1.8	2.5	2.1	-2.9
Length with tail	1.4	6.1	13.7	0.5	-0.5	3.1	3.7	2.6	1.9	2.8	-2.7
Length without tail	0.7	2.2	4.6	-1.2	-1.6	1.2	1.8	2.1	-0.5	2.0	-0.4
Times rat made contact with spout	0.5	0.6	1.3	-0.7	-0.6	0.6	1.1	0.9	-0.0	1.0	-0.5
Lifetime Intake	1.2	1.4	3.7	0.4	1.0	-0.8	-1.5	-1.9	0.1	-1.9	0.3
Liver weight, left	0.9	1.4	4.7	-0.9	-1.1	2.2	1.2	0.1	0.7	0.0	-1.7
Liver weight, right	2.6	4.6	11.7	-1.4	-1.8	3.4	2.7	1.3	1.2	1.2	-2.8
Locomotor activity	0.6	1.0	2.1	0.7	0.9	-0.1	1.4	1.2	1.0	1.4	-0.5
Locomotor testing distance	1.4	2.6	7.0	1.7	1.8	0.7	1.7	0.5	2.6	0.8	-1.8
Locomotor testing rearing	1.5	3.0	6.0	0.8	0.8	1.6	2.4	1.1	2.4	1.3	-2.3
Locomotion in novel chamber	1.7	2.2	5.1	-0.3	0.2	-1.5	-2.3	-1.7	-1.2	-1.8	1.6
Locomotion in novel chamber post-restriction	1.8	3.0	5.9	1.4	1.9	-2.4	-2.2	-1.5	-0.4	-1.3	1.8
Fecal boli incidents, locomotor time 1	2.3	3.3	8.7	0.6	1.4	-0.4	-2.2	-2.9	1.3	-3.0	-0.0
Change in fecal boli incidents, locomotor task	1.6	1.6	4.3	-0.6	-1.0	-0.1	1.1	2.1	-1.2	2.0	0.7
Time >=10cm from walls, locomotor time 1	1.1	1.1	2.4	0.6	0.8	-1.2	-1.6	-1.2	-0.5	-1.2	1.0
Bouts of movement, locomotor time 1	0.8	1.0	2.6	1.6	1.5	-1.0	0.1	0.4	0.9	0.7	0.5
Total resting periods, locomotor time 1	0.8	0.9	2.1	1.3	1.3	-1.5	-0.2	0.4	0.3	0.7	1.1
Rest time, locomotor task time 1	0.6	0.8	1.9	0.9	1.0	-1.4	-0.9	-0.1	-0.4	0.0	1.3
Distance moved, locomotor task time 1	0.5	0.8	2.6	0.4	0.1	1.0	1.0	-0.1	1.4	-0.0	-1.6
Vertical activity count, locomotor time 1	0.2	0.5	1.3	0.5	0.3	0.6	0.8	0.0	1.2	0.1	-1.1
Time >=10cm from walls, locomotor time 2	0.5	0.8	1.5	0.9	0.9	0.6	-0.5	-1.2	0.8	-1.1	-0.6
Bouts of movement, locomotor time 2	0.1	0.2	0.5	0.4	0.7	0.4	0.2	-0.1	0.7	0.0	-0.4
Total resting periods, locomotor time 2	0.1	0.2	0.5	0.3	0.6	0.3	0.1	-0.2	0.7	-0.1	-0.3
Rest time, locomotor task time 2	0.3	0.4	1.9	-1.4	-0.9	-0.0	-0.1	0.2	-0.7	0.0	0.3
Distance moved, locomotor task time 2	1.0	1.2	2.4	1.1	0.8	0.6	-0.0	-1.3	1.5	-1.2	-1.4
Vertical activity count, locomotor time 2	0.8	1.0	2.9	1.0	0.9	0.7	0.4	-0.7	1.7	-0.6	-1.5
Light reinforcement 1	0.5	1.2	2.0	-1.2	-1.4	1.3	1.3	1.1	0.1	0.9	-0.8
Light reinforcement 2	0.2	0.3	1.2	-0.9	-1.1	0.4	-0.2	-0.0	-0.7	-0.3	0.0
Bone: marrow area	0.6	1.4	2.9	1.5	1.3	1.0	0.4	-0.8	1.7	-0.5	-1.4
Bone: maximum diameter	0.7	1.3	3.6	1.9	1.6	0.3	0.2	-0.5	1.7	-0.3	-0.9
Bone: maximum force	0.3	0.5	1.2	0.5	0.3	-1.1	-1.1	-0.6	-0.3	-0.6	0.9
Bone: maximum moment	0.3	0.5	1.0	0.5	0.4	-1.0	-1.0	-0.6	-0.2	-0.6	0.8
Mean time between licks in bursts	0.8	1.8	4.4	1.0	0.9	1.4	0.5	-1.3	1.9	-1.1	-2.1
Mean num. licks in bursts	0.9	1.4	3.0	1.3	1.7	-0.7	-1.1	-1.6	0.4	-1.4	0.1
Cd content in liver	0.8	0.9	1.8	0.9	0.3	0.5	1.3	1.2	0.9	1.3	-0.7
Co content in liver	0.9	1.0	2.3	1.0	1.2	0.4	0.1	-1.0	1.5	-0.8	-1.2
Cu content in liver	1.7	2.0	3.7	1.0	0.6	1.6	1.9	0.9	1.7	1.1	-1.9
Fe content in liver	0.2	0.3	0.7	-0.5	-0.4	0.5	-0.4	-0.7	0.0	-0.9	-0.3
K content in liver	0.4	0.3	1.1	-1.1	-0.8	0.7	0.3	0.3	-0.6	0.2	-0.1
Mg content in liver	0.0	0.0	0.0	-0.2	-0.0	0.2	-0.0	-0.0	-0.1	-0.0	0.1
Mn content in liver	1.0	1.1	2.5	-1.6	-1.1	-0.4	-1.0	-0.4	-1.4	-0.6	1.0
Na content in liver	0.9	1.0	2.1	-1.5	-1.1	0.3	-0.9	-1.0	-0.8	-1.3	0.0
Rb content in liver	0.4	0.5	1.3	0.6	0.4	-0.4	0.8	1.0	0.1	1.1	0.1
Se content in liver	2.0	2.4	7.0	-2.6	-2.6	0.8	-0.0	0.6	-1.9	0.2	0.5
Sr content in liver	0.5	0.4	0.7	0.4	0.7	-0.9	-0.8	-0.8	0.2	-0.8	0.3
Zn content in liver	1.9	2.1	5.5	1.7	1.7	1.0	1.0	-0.3	2.3	0.0	-1.8
Bone: minimum diameter	0.9	1.7	3.8	1.1	0.9	1.7	1.1	-0.2	1.8	-0.0	-2.0
Time in familiar zone, hab. session 1	0.0	0.0	0.1	-0.1	0.2	-0.1	-0.2	-0.3	-0.0	-0.3	0.0
Time in novel zone, hab. session 1	0.6	0.6	1.3	0.3	-0.3	0.5	1.1	1.1	0.5	1.1	-0.6
Total zone transitions, hab. session 1	0.7	1.0	2.4	-0.1	-0.2	-1.1	-0.1	1.2	-1.2	1.2	1.6
Total locomotion distance, hab. session 1	3.9	5.5	10.7	-2.6	-2.8	3.3	2.7	2.0	0.2	1.7	-2.1
Locomotion velocity, hab. session 1	3.5	4.9	10.4	-2.7	-2.8	3.2	2.4	1.6	0.1	1.3	-2.0
Time in familiar zone, hab. session 2	0.4	0.5	1.9	1.2	1.4	-0.4	0.1	-0.1	0.5	0.1	-0.1
Time in novel zone, hab. session 2	0.2	0.2	0.6	-0.3	-0.4	0.3	-0.4	-0.7	0.4	-0.8	-0.3
Total zone transitions, hab. session 2	0.6	0.7	1.6	0.6	0.3	-1.0	-0.0	1.0	-0.6	1.1	1.3
Total locomotion distance, hab. session 2	2.7	3.6	7.5	-1.3	-1.6	2.7	2.5	1.8	0.7	1.7	-1.9
Locomotion velocity, hab. session 2	3.1	4.1	7.9	-1.2	-1.6	2.8	2.8	2.1	0.8	2.0	-2.0
Novel to familiar place preference ratio	0.1	0.1	0.4	-0.2	-0.6	-0.1	0.2	0.5	-0.3	0.4	0.1
Novelty place preference	0.1	0.1	0.1	0.1	-0.3	-0.2	0.2	0.4	-0.1	0.4	0.1
Time in novel zone, NPP test	0.1	0.1	0.2	0.4	-0.0	-0.5	0.1	0.3	-0.0	0.3	0.2
Total zone transitions, NPP test	0.4	0.6	1.6	0.6	0.6	-1.2	-0.9	-0.1	-0.6	-0.0	1.3
Total locomotion distance, NPP test	2.2	3.1	8.6	-1.9	-2.1	2.9	1.6	0.4	0.7	0.1	-2.2
Locomotion velocity, NPP test	2.8	4.0	10.9	-2.3	-2.5	3.3	1.8	0.6	0.6	0.2	-2.3
Intraocular pressure	2.5	3.7	5.6	2.0	2.2	-2.4	-2.3	-2.0	0.2	-1.7	1.6
Delta distance traveled before/after self-admin	0.3	0.3	0.7	-0.8	-0.8	-0.2	-0.2	0.4	-0.5	0.2	0.7
Delta ambulatory time before/after self-admin	0.3	0.4	1.1	-0.5	-0.4	-0.7	-0.3	0.5	-0.6	0.5	1.0
Parametrial fat weight	0.8	1.8	4.1	-0.8	-1.3	1.0	1.7	2.0	-0.1	1.9	-0.4
Pavlov. Cond. lever latency	0.5	0.7	1.9	-0.7	-0.5	-0.2	0.9	1.4	0.0	1.3	0.3
Pavlov. Cond. magazine entry latency	0.7	0.9	2.4	1.6	1.2	-0.0	-0.0	-0.7	1.3	-0.5	-0.8
Pavlov. Cond. change in total contacts	1.1	1.2	3.9	0.3	0.2	0.5	-1.1	-1.9	0.3	-2.0	-0.7
Pavlov. Cond. index score	0.8	1.0	1.8	1.3	1.0	0.4	-0.3	-1.2	1.1	-1.1	-1.0
Pavlov. Cond. latency score	0.6	0.8	1.5	1.1	0.7	0.4	-0.4	-1.2	0.7	-1.2	-0.8
Pavlov. Cond. lever contacts	0.4	0.5	1.2	0.7	0.5	0.5	-0.5	-1.1	0.3	-1.1	-0.6
Pavlov. Cond. magazine entry number	0.9	1.1	2.8	-1.7	-1.4	-0.1	0.0	0.8	-1.5	0.6	0.9
Pavlov. Cond. intertrial magazine entries	0.5	0.6	1.7	-1.3	-1.2	0.9	0.3	0.3	-0.9	0.2	-0.2
Pavlov. Cond. lever-magazine prob. diff.	0.7	0.8	1.5	1.2	1.0	0.2	-0.5	-1.2	0.8	-1.1	-0.7
Pavlov. Cond. response bias	0.4	0.5	1.0	1.0	0.9	0.3	-0.2	-0.8	0.9	-0.7	-0.7
Pavlov. Cond. lever latency	7.1	9.7	28.4	-5.3	-5.0	2.4	1.5	2.1	-3.1	1.4	-0.2
Pavlov. Cond. magazine entry latency	3.7	4.5	10.3	3.2	3.1	-2.5	-1.7	-1.5	1.3	-1.1	1.0
Pavlov. Cond. change in total contacts	3.7	5.9	18.8	4.3	3.9	-1.6	-0.8	-1.4	2.7	-0.8	-0.1
Pavlov. Cond. index score	6.1	8.2	23.0	4.8	4.6	-2.4	-1.6	-2.0	2.6	-1.4	0.3
Pavlov. Cond. latency score	5.6	7.4	20.9	4.6	4.3	-2.5	-1.7	-1.9	2.2	-1.3	0.6
Pavlov. Cond. lever contacts	6.7	9.3	29.5	5.4	5.0	-2.3	-1.1	-1.6	3.1	-0.9	0.1
Pavlov. Cond. magazine entry number	6.9	8.5	19.7	-4.3	-4.4	2.8	2.3	2.6	-2.0	2.1	-0.8
Pavlov. Cond. intertrial magazine entries	1.7	2.5	7.2	-0.8	-0.9	2.7	2.0	0.8	1.1	0.8	-2.2
Pavlov. Cond. lever-magazine prob. diff.	5.8	7.8	22.0	4.7	4.4	-2.2	-1.5	-2.0	2.7	-1.4	0.2
Pavlov. Cond. response bias	7.9	10.8	29.8	5.5	5.3	-2.4	-1.7	-2.4	3.4	-1.7	0.1
Time in closed arm before self-admin	0.2	0.3	1.0	-0.1	-0.0	-1.0	-0.7	-0.2	-0.5	-0.2	0.9
Time in closed arm after self-admin	1.1	1.1	3.7	0.2	0.3	-1.9	-1.2	-0.2	-0.9	-0.2	1.7
Time in open arm before self-admin	0.5	0.5	1.0	-1.0	-0.9	0.9	0.8	0.5	0.4	0.3	-0.8
Time in open arm after self-admin	0.6	0.6	2.2	-0.2	-0.2	1.5	0.9	0.1	0.6	0.1	-1.3
Bone: periosteal estimation	0.9	1.9	4.3	1.8	1.5	1.0	0.2	-1.1	2.1	-0.9	-1.6
Bone: periosteal perimeter	0.9	1.6	4.9	2.2	1.9	0.1	0.9	0.3	1.6	0.7	-0.8
Bone: post-yield work	0.2	0.2	0.7	-0.2	-0.4	-0.5	-0.2	0.3	-0.8	0.3	0.7
Progressive ratio test 1 active lever presses	0.5	0.7	1.5	-0.3	-0.0	-1.2	-1.0	-0.3	-1.1	-0.4	1.2
Progressive ratio test 1 breakpoint	0.6	0.7	1.6	-0.2	0.1	-1.3	-1.1	-0.4	-1.1	-0.4	1.3
Progressive ratio test 1 inactive lever presses	0.4	0.5	1.3	-1.1	-0.7	-0.4	-0.5	0.1	-0.9	-0.0	0.9
Progressive ratio test 2 active lever presses	0.7	0.8	2.4	0.5	0.6	-0.1	-0.9	-1.5	0.2	-1.5	-0.2
Progressive ratio test 2 breakpoint	0.8	0.9	2.8	0.5	0.6	-0.1	-1.0	-1.7	0.2	-1.6	-0.2
Progressive ratio test 2 inactive lever presses	0.1	0.1	0.2	0.1	0.1	-0.2	-0.4	-0.5	-0.3	-0.4	0.2
Incentive Sensitization - Responses	0.4	0.6	1.2	0.9	0.8	0.4	-0.3	-1.1	0.7	-1.0	-0.7
Incentive Sensitization - Breakpoint	0.5	0.6	1.3	0.7	0.6	0.5	-0.3	-1.2	0.6	-1.1	-0.8
Sum of active levers in priming session hrs 5-6	0.4	0.4	0.5	-0.7	-0.7	0.7	0.7	0.7	-0.2	0.6	-0.2
Progressive ratio	1.0	1.6	2.7	1.3	1.6	-1.4	-1.5	-1.3	0.5	-1.2	0.8
Food seeking constrained by brief footshock	1.5	1.8	5.2	1.6	1.7	0.4	1.1	0.2	2.3	0.5	-1.4
Seeking ratio, punishment vs. effort	1.7	2.4	6.0	-0.9	-1.1	2.5	2.0	0.7	1.0	0.7	-2.3
Retroperitoneal fat weight	3.7	15.7	35.1	-1.2	-2.4	4.8	5.9	4.5	1.9	4.6	-3.8
Reaction time number correct	0.3	0.5	1.2	-0.4	-0.1	-1.1	-0.0	0.8	-0.5	0.8	1.0
Reaction time mean minus median	0.2	0.5	1.5	1.2	1.0	-0.1	0.6	0.3	1.0	0.5	-0.5
Reaction time mean minus median AUC	0.1	0.3	0.9	1.0	0.8	-0.5	0.2	0.2	0.4	0.4	0.1
Reaction time num false alarms	0.5	0.6	1.3	-0.5	-0.7	1.1	1.0	1.0	0.1	1.0	-0.5
Reaction time num false alarms AUC	0.1	0.1	0.4	-0.3	-0.3	0.6	0.3	0.3	0.0	0.3	-0.1
Reaction time trials correct on left	0.3	0.5	1.2	-0.4	-0.1	-1.1	-0.0	0.8	-0.5	0.8	1.0
Reaction time trials on left	0.3	0.5	1.2	-0.4	-0.1	-1.1	-0.0	0.8	-0.5	0.8	0.9
Reaction time mean	0.2	0.4	0.8	-0.5	-0.9	0.9	0.7	0.5	0.1	0.3	-0.7
Reaction time mean AUC	0.2	0.2	0.8	-0.5	-0.9	0.6	0.4	0.4	-0.2	0.3	-0.3
Median of all reaction times	0.3	0.5	1.7	-0.9	-1.3	0.9	0.3	0.2	-0.2	-0.0	-0.5
Reaction time omissions	0.5	0.7	2.2	0.9	0.2	0.7	0.8	0.2	1.5	0.2	-1.2
Reaction time false alarm rate	0.2	0.2	1.1	-0.3	-0.4	1.0	0.1	-0.2	0.1	-0.3	-0.5
Reaction time premature initiation rate	1.9	2.6	6.2	0.5	-0.2	2.4	2.0	0.6	1.8	0.7	-2.5
Reaction time premature initiations	0.8	1.5	3.0	0.3	-0.2	1.6	1.7	0.8	1.3	0.8	-1.7
Std. dev. reaction times	0.5	0.8	1.8	1.0	0.5	0.8	1.1	0.4	1.3	0.6	-1.2
Reaction time trials completed	0.3	0.5	1.2	-0.4	-0.1	-1.1	-0.0	0.8	-0.5	0.8	0.9
Reaction time trials AUC	0.2	0.4	0.8	-0.3	-0.1	-0.9	0.2	0.9	-0.3	0.9	0.7
Run reversals in cocaine runway, females	1.9	1.9	3.9	1.1	0.6	1.3	2.0	1.1	1.5	1.3	-1.7
Run reversals in cocaine runway, males	1.5	1.5	4.0	1.5	1.7	-2.0	-0.9	-0.3	-0.0	-0.0	1.4
Latency to leave start box in cocaine runway	1.5	1.8	5.3	-2.1	-2.3	1.5	0.8	0.5	-0.5	0.1	-0.9
Latency to leave start box in cocaine runway, F	1.8	2.0	4.5	-1.8	-1.9	2.1	1.1	0.2	0.4	-0.1	-1.8
Latency to leave start box in cocaine runway, M	0.7	0.6	1.7	-1.1	-1.3	-0.1	-0.4	0.1	-1.2	-0.1	0.6
Std. dev. time between licks in bursts	1.3	1.8	4.1	0.1	-0.1	2.0	1.7	0.5	1.5	0.6	-2.0
Total sessions with >9 infusions	1.4	1.7	4.4	0.5	1.2	-0.5	-1.5	-2.1	0.8	-2.1	-0.2
Short access day 1 total inactive lever presses	0.3	0.5	0.9	1.0	1.0	-0.8	-0.6	-0.5	0.4	-0.4	0.4
Short access day 10 total inactive lever presses	0.7	1.8	4.4	-1.2	-1.4	0.3	1.2	2.1	-0.9	2.0	0.5
Short access day 1 total infusions	1.0	1.4	3.3	0.9	1.2	0.1	-0.9	-1.8	1.1	-1.7	-0.7
Short access day 10 total infusions	1.3	1.7	3.8	1.0	1.5	-0.6	-1.2	-2.0	1.1	-1.8	-0.3
Short access total infusions	1.5	1.9	4.5	0.9	1.5	-0.8	-1.5	-2.1	0.9	-2.0	-0.0
Short access day 1 locomotion	1.6	1.9	3.1	1.3	1.6	-1.6	-1.8	-1.6	0.3	-1.4	1.1
Short access day 10 total locomotion	0.4	0.7	1.6	0.9	1.3	-0.6	-0.6	-0.9	0.9	-0.7	0.1
Short access total locomotion	0.5	0.6	1.3	-0.3	0.3	-0.7	-1.1	-1.1	0.0	-1.1	0.5
One hour access (0.3 mA shock)	0.5	0.5	1.4	0.9	1.2	-0.4	-0.4	-0.9	0.7	-0.7	-0.2
Compulsive drug intake	0.6	0.7	1.9	-1.2	-1.2	0.2	-0.1	0.5	-1.4	0.3	0.6
One hour access (shock baseline)	1.1	1.7	2.9	1.2	1.7	-1.2	-1.3	-1.7	0.8	-1.5	0.2
Social response proportion	1.4	1.6	3.3	-1.8	-1.7	1.4	1.3	1.3	-0.2	1.0	-0.7
Social responses	1.6	2.1	4.8	-0.4	-0.7	1.4	2.2	1.8	1.1	1.9	-1.2
Social time	1.0	1.4	3.6	-1.7	-1.9	1.0	0.9	1.1	-0.4	0.9	-0.3
Soleus weight	0.9	2.7	6.1	0.3	-0.2	2.1	2.5	1.7	1.3	1.9	-1.7
Bone: stiffness	0.2	0.3	0.6	-0.4	-0.8	-0.6	-0.3	0.5	-0.7	0.3	0.8
Tibialis anterior weight	0.3	1.0	2.1	0.4	-0.1	0.9	1.4	1.3	0.8	1.4	-0.7
Time to tail flick, vehicle, before self-admin	0.2	0.2	0.6	0.5	0.5	0.3	0.3	-0.0	0.8	0.1	-0.4
Time to tail flick, vehicle, after self-admin	0.7	0.9	2.8	1.5	1.7	-0.8	-0.4	-0.6	1.0	-0.3	0.0
Time to tail flick, test, before self-admin	0.6	0.6	2.3	1.5	1.4	-0.2	-0.0	-0.3	0.8	-0.1	-0.3
Time to tail flick, test, after self-admin	1.1	1.2	3.9	1.4	1.4	0.3	0.6	-0.3	2.0	-0.1	-1.1
Delta time to tail flick, vehicle, before/after SA	0.7	0.6	1.3	0.8	0.9	-1.2	-0.9	-0.8	-0.0	-0.7	0.5
Delta time to tail flick, test, before/after SA	0.3	0.4	0.9	-0.9	-0.9	0.3	0.6	0.7	0.0	0.6	-0.2
Tibia length	0.4	1.2	2.6	0.7	1.2	-0.3	-1.4	-1.6	0.6	-1.6	0.3
Ambulatory time before self-admin	0.3	0.4	1.4	-0.4	-0.6	-0.4	-0.3	0.3	-1.2	0.3	0.9
Ambulatory time after self-admin	1.3	1.5	3.5	-1.4	-1.5	-0.6	-0.5	0.8	-1.9	0.6	1.7
Bone: tissue strength	2.8	2.8	7.0	-1.9	-2.2	-1.1	-0.6	1.0	-2.6	0.7	2.0
Total heroin consumption	0.1	0.1	0.3	-0.1	-0.0	0.2	0.4	0.5	-0.0	0.5	-0.0
Bone: trabecular number	0.4	0.6	1.6	-0.7	-0.9	-0.7	-0.4	0.4	-1.3	0.3	1.1
Bone: trabecular spacing	0.4	0.5	1.3	0.3	0.6	0.1	-0.6	-1.2	0.6	-1.2	-0.4
Bone: trabecular thickness	1.0	1.3	4.0	1.0	0.3	0.0	1.4	1.8	0.3	2.0	-0.0
Bone: trabecular tissue density	2.1	3.0	8.0	-0.7	-1.1	0.8	2.4	2.8	-0.0	2.8	-0.4
Water consumed over 24 hours	0.5	0.6	1.2	-0.7	-0.7	-0.2	0.6	1.1	-1.0	1.1	0.5
Number of responses in last shaping day	1.8	2.0	5.9	-1.3	-1.4	2.4	1.4	0.2	0.7	-0.0	-2.0