Relt

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	gene expression	Relt	0.05	0.04	1.2e-04	0.02	0.02	0.03	0.02	1.4e-03	1.1e-03	1.7e-04	1.5e-03
2	Brain	isoform ratio	XM_006229777.4	0.09	0.05	5.6e-07	0.08	0.06	0.05	0.06	7.7e-08	2.6e-06	1.8e-05	1.9e-06
3	Brain	mRNA stability	Relt	0.06	0.04	1.3e-05	0.05	0.05	0.04	0.05	3.6e-05	1.5e-05	6.9e-05	2.3e-05
4	Brain	intron excision ratio	chr1_155214188_155224455	0.13	0.07	9.1e-11	0.11	0.11	0.11	0.12	1.4e-10	1.1e-10	1.3e-10	8.8e-11
5	PL	intron excision ratio	chr1_155214188_155224455	0.05	0.03	4.4e-05	0.03	0.03	0.03	0.03	1.1e-04	1.8e-04	5.8e-04	4.0e-04
6	pVTA	intron excision ratio	chr1_155214188_155224455	0.17	0.09	1.3e-05	0.14	0.13	0.13	0.13	1.6e-06	2.4e-06	2.8e-06	2.6e-06
7	NAcc	intron excision ratio	chr1_155214188_155224455	0.07	0.05	1.3e-05	0.03	0.04	0.03	0.04	2.5e-04	6.0e-06	1.1e-04	2.1e-05
8	Adipose	mRNA stability	Relt	0.04	0.03	3.4e-04	0.02	0.02	0.02	0.02	3.1e-03	1.2e-03	2.2e-03	4.1e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6	7	8
Bone: apparent density	0.1	0.1	0.3	0.0	0.6	-0.2	-0.4	0.5	0.4	-0.4	0.2
Area under the delay curve	0.1	0.1	0.2	0.4	0.5	-0.4	-0.3	0.2	0.2	-0.3	-0.5
BMI with tail	0.1	0.3	0.8	0.9	0.8	-0.5	-0.5	-0.2	-0.0	-0.3	-0.5
BMI without tail	0.5	1.0	2.1	0.2	-0.5	0.3	1.1	-1.4	-1.4	1.4	-0.5
Body weight	0.2	1.0	2.0	0.3	-0.8	0.1	1.1	-1.4	-1.2	1.2	-1.1
Weight adjusted by age	0.5	0.5	1.0	-0.3	-0.8	0.5	0.8	-0.8	-1.0	0.9	0.0
Bone surface	0.9	1.6	1.7	-1.3	-1.2	1.3	1.2	-1.2	-1.3	1.3	1.2
Bone volume	0.5	0.9	1.0	-1.0	-0.9	1.0	0.9	-0.9	-0.9	0.9	0.9
Breakpoint value in progressive ratio session	0.3	0.3	0.6	0.1	0.8	-0.4	-0.6	0.7	0.7	-0.7	-0.0
Number of licking bursts	5.4	6.3	7.9	2.8	2.4	-2.8	-2.3	2.4	2.4	-2.2	-2.8
Context. condit. distance diff. score	2.7	3.3	5.3	-2.3	-1.6	2.0	1.7	-1.5	-1.5	1.5	2.1
Locomotion velocity, session 1	0.3	0.4	0.7	0.3	0.8	-0.4	-0.7	0.6	0.7	-0.7	0.2
Locomotion distance, session 1	0.8	1.1	2.0	-1.3	-0.9	1.1	0.8	-0.8	-0.8	0.8	1.4
Locomotion velocity, session 2	0.1	0.2	0.5	-0.4	-0.7	0.3	0.3	-0.3	-0.3	0.4	0.3
Locomotion distance, session 2	0.4	0.6	0.9	-0.9	-0.8	0.8	0.7	-0.7	-0.7	0.6	0.8
Locomotion velocity, session 3	0.7	0.8	1.8	-1.4	-0.9	0.9	0.6	-0.6	-0.4	0.5	1.2
Locomotion distance, session 3	1.1	1.2	2.9	-1.6	-0.7	1.3	0.8	-0.8	-0.7	0.8	1.7
Stereotopy head waving bouts, day 3	0.2	0.2	0.9	0.5	-0.3	-0.6	-0.2	0.4	0.4	-0.3	-1.0
Stereotopy head waving duration, day 3	0.1	0.1	0.3	-0.5	-0.5	0.3	0.2	-0.1	-0.1	0.1	0.4
Locomotion velocity, session 7	0.3	0.3	0.5	0.4	0.5	-0.5	-0.7	0.6	0.7	-0.6	-0.2
Locomotion distance, session 7	0.2	0.3	0.6	0.8	0.4	-0.5	-0.5	0.4	0.4	-0.5	-0.6
Stereotopy head waving bouts, day 7	3.3	3.8	6.4	-2.5	-1.9	2.0	1.7	-1.6	-1.6	1.8	2.2
Stereotopy head waving duration, day 7	3.9	4.7	7.0	-2.7	-2.0	2.2	2.0	-2.0	-1.9	2.1	2.4
Locomotion velocity, session 8	1.2	1.4	2.3	-1.5	-1.4	1.2	1.2	-0.9	-0.8	1.0	1.2
Locomotion distance, session 8	2.7	4.0	6.0	-2.5	-1.8	2.2	2.0	-1.8	-1.8	1.8	2.1
Degree of sensitization distance	0.7	0.7	3.0	1.3	-0.1	-0.9	-0.2	0.3	0.2	-0.2	-1.7
Degree of sensitization stereotypy	6.8	7.5	11.6	-3.4	-2.5	2.9	2.5	-2.4	-2.4	2.5	3.1
Conditioned locomotion	0.1	0.1	0.4	0.1	0.4	-0.2	-0.3	0.4	0.4	-0.7	-0.3
Cocaine response after cond. corrected	2.0	2.2	3.4	1.9	1.6	-1.6	-1.3	1.2	1.2	-1.1	-1.8
Cocaine response after cond. not corrected	0.7	0.7	1.3	1.1	1.1	-0.9	-0.8	0.7	0.7	-0.6	-0.8
Cocaine response before conditioning	1.7	2.0	4.6	-1.8	-1.1	1.6	1.0	-1.2	-1.1	1.1	2.1
Saline control response	3.0	3.9	6.9	-1.8	-2.6	1.8	2.1	-2.0	-2.0	2.0	1.2
Bone: connectivity density	0.1	0.1	0.7	-0.2	0.5	0.1	-0.3	0.2	0.1	-0.1	0.8
Bone: cortical apparent density	1.9	2.5	4.5	1.9	1.2	-1.8	-1.4	1.4	1.4	-1.4	-2.1
Bone: cortical area	0.5	0.7	1.3	-0.7	-1.1	0.7	1.0	-0.9	-0.9	0.9	0.2
Bone: cortical porosity	0.7	0.8	1.8	-1.2	-0.5	1.1	0.6	-0.7	-0.7	0.5	1.4
Bone: cortical porosity	0.6	0.6	1.5	-1.1	-0.5	1.0	0.5	-0.6	-0.6	0.4	1.2
Bone: cortical thickness	0.1	0.2	0.3	0.3	0.2	-0.4	-0.4	0.5	0.5	-0.5	-0.4
Bone: cortical thickness	0.1	0.1	0.2	-0.4	-0.5	0.4	0.2	-0.2	-0.3	0.1	0.4
Bone: cortical tissue density	2.0	2.6	4.4	2.0	1.2	-1.8	-1.4	1.4	1.4	-1.4	-2.1
Condit. Reinf. active minus inactive responses	0.3	0.4	1.0	-0.3	-1.0	0.4	0.7	-0.6	-0.6	0.7	-0.1
Condit. Reinf. active-inactive response ratio	0.7	0.8	1.3	-0.5	-1.1	0.7	1.0	-1.0	-1.0	1.1	0.2
Condit. Reinf. active responses	0.1	0.1	0.4	-0.1	-0.6	0.1	0.3	-0.2	-0.2	0.2	-0.3
Condit. Reinf. inactive responses	0.1	0.1	0.2	0.2	0.2	-0.2	-0.3	0.3	0.3	-0.4	-0.3
Incentive salience index mean	0.3	0.4	1.0	-0.4	-1.0	0.5	0.7	-0.7	-0.7	0.7	0.0
Condit. Reinf. lever presses	0.1	0.2	0.4	-0.4	-0.6	0.3	0.4	-0.5	-0.4	0.5	0.3
Condit. Reinf. active minus inactive responses	9.8	12.2	16.5	-3.3	-4.1	3.3	3.7	-3.6	-3.6	3.7	2.5
Condit. Reinf. active-inactive response ratio	2.4	2.5	2.8	-1.6	-1.6	1.6	1.6	-1.6	-1.7	1.7	1.4
Condit. Reinf. active responses	12.4	17.1	24.6	-3.8	-5.0	3.9	4.4	-4.3	-4.3	4.4	2.7
Condit. Reinf. inactive responses	7.0	8.6	14.2	-2.6	-3.8	2.7	3.2	-3.1	-3.0	3.1	1.6
Condit. Reinf. lever presses	22.0	29.9	33.7	-5.4	-5.8	5.5	5.6	-5.6	-5.7	5.6	4.5
Condit. Reinf. lever reinforcers received	14.0	19.6	26.9	-4.2	-5.2	4.2	4.7	-4.5	-4.6	4.7	3.1
Conditioned reinforcement - actives	2.4	2.4	3.7	-1.6	-1.6	1.8	1.3	-1.6	-1.5	1.1	1.9
Conditioned reinforcement - inactives	0.1	0.1	0.3	0.5	-0.0	-0.3	-0.1	0.1	0.2	-0.2	-0.6
Conditioned locomotion	2.4	2.9	5.3	-2.1	-1.5	2.0	1.4	-1.4	-1.5	1.2	2.3
Patch foraging indifference point 0 sec	3.7	6.0	7.5	-2.3	-2.2	2.7	2.3	-2.7	-2.6	2.3	2.4
Patch foraging indifference point AUC	0.2	0.2	0.6	-0.1	-0.8	-0.0	0.4	-0.4	-0.5	0.5	-0.5
Delay disc. indifference point, 0s delay	0.8	0.9	1.1	-1.0	-0.9	0.9	1.1	-1.0	-1.0	1.0	0.6
Delay disc. indifference point, 16s delay	0.3	0.3	0.9	0.4	1.0	-0.3	-0.6	0.4	0.4	-0.6	-0.4
Delay disc. indifference point, 2s delay	0.8	0.9	1.3	-0.9	-0.9	0.7	1.1	-1.0	-1.0	1.1	0.3
Delay disc. indifference point, 24s delay	1.8	1.7	2.9	1.2	1.7	-1.2	-1.3	1.2	1.2	-1.4	-1.2
Delay disc. indifference point, 4s delay	0.9	0.9	1.5	-0.7	-1.2	0.7	1.2	-1.1	-1.1	1.2	0.1
Delay disc. indifference point, 8s delay	0.0	0.0	0.0	0.1	0.0	-0.1	-0.2	0.1	0.1	-0.1	-0.1
Indifference point function ln k	0.7	1.0	3.1	-1.3	-0.3	1.3	0.6	-0.7	-0.6	0.4	1.8
Indifference point function log k	0.7	1.0	3.1	-1.3	-0.3	1.3	0.6	-0.7	-0.6	0.4	1.8
Patch foraging total patch changes 0 sec	2.9	4.7	6.1	-2.0	-2.0	2.3	2.0	-2.5	-2.4	2.1	2.1
Patch foraging total patch changes 12 sec	1.3	1.7	3.0	-0.8	-1.6	1.1	1.4	-1.6	-1.7	1.4	0.3
Patch foraging total patch changes 18 sec	2.2	2.8	4.4	-1.2	-1.9	1.6	1.5	-2.1	-2.0	1.6	1.2
Patch foraging total patch changes 24 sec	1.3	1.6	2.7	-0.7	-1.7	1.1	1.3	-1.6	-1.5	1.4	0.4
Patch foraging total patch changes 6 sec	0.4	0.7	0.9	-0.8	-0.8	0.9	0.7	-0.9	-0.9	0.7	0.8
Patch foraging time to switch 0 sec	4.1	6.4	7.6	2.5	2.5	-2.6	-2.6	2.5	2.7	-2.6	-2.1
Patch foraging water rate 0 sec	3.2	5.1	5.9	-2.3	-2.0	2.4	2.2	-2.3	-2.4	2.1	2.2
Patch foraging water rate 12 sec	2.1	3.2	4.2	-1.8	-1.7	2.0	1.7	-1.8	-1.8	1.6	2.1
Patch foraging water rate 18 sec	2.1	2.8	3.8	-1.8	-1.9	1.6	1.9	-1.4	-1.6	1.9	1.3
Patch foraging water rate 24 sec	0.7	1.0	2.5	-1.2	-0.7	1.3	0.7	-0.7	-0.9	0.6	1.6
Patch foraging water rate 6 sec	1.1	1.7	2.5	-1.5	-1.1	1.5	1.2	-1.0	-1.1	1.1	1.6
Seeking ratio, delayed vs. immediate footshock	1.4	1.6	2.2	1.2	1.5	-1.1	-1.5	1.3	1.4	-1.3	-0.5
Distance traveled before self-admin	1.9	2.0	2.6	1.6	1.2	-1.5	-1.3	1.3	1.3	-1.4	-1.5
Distance traveled after self-admin	0.3	0.4	1.0	-0.2	0.3	-0.2	-0.5	0.9	1.0	-0.7	0.2
Extensor digitorum longus weight	0.1	0.4	1.3	1.1	0.4	-0.7	-0.2	-0.0	0.0	0.0	-1.1
Bone: elastic displacement	2.5	2.8	3.8	1.3	1.8	-1.6	-1.8	1.9	2.0	-1.8	-1.0
Bone: elastic work	2.6	3.3	5.3	1.5	2.3	-1.6	-2.1	2.0	2.0	-1.9	-0.7
Bone: endosteal estimation	1.4	3.0	4.4	-1.2	-1.7	1.5	2.0	-2.1	-2.1	2.1	0.7
Bone: endosteal perimeter	2.0	4.1	5.6	-1.7	-2.1	1.9	2.3	-2.3	-2.3	2.4	1.1
Epididymis fat weight	0.6	1.3	3.5	1.9	1.0	-1.3	-0.7	0.2	0.5	-0.5	-1.9
Delta time in closed arm before/after self-admin	1.8	1.8	5.2	2.0	0.9	-1.5	-0.8	0.5	0.5	-0.7	-2.3
Delta time in open arm before/after self-admin	4.5	4.3	4.9	-2.1	-2.1	2.2	2.1	-2.0	-2.1	2.1	2.0
Diff in mean of infusions in LGA sessions	2.5	2.8	4.0	1.6	1.0	-2.0	-1.3	2.0	1.8	-1.5	-1.9
Delay discount exponential model param	0.2	0.2	0.3	-0.5	-0.5	0.5	0.4	-0.3	-0.3	0.3	0.5
Extinction: sum of active levers before priming	0.1	0.1	0.1	0.4	0.3	-0.3	-0.3	0.2	0.2	-0.2	-0.3
Active lever presses in extinction session 6	1.8	1.7	4.6	-2.0	-0.8	1.6	0.8	-0.6	-0.7	0.7	2.1
Bone: final force	0.0	0.1	0.2	0.2	0.4	-0.1	-0.1	0.1	0.1	-0.3	-0.5
Bone: final moment	0.0	0.0	0.1	-0.0	0.2	0.1	0.2	-0.2	-0.2	0.0	-0.2
Food consumed during 24 hour testing period	4.3	5.2	7.5	-2.7	-1.9	2.5	2.1	-2.0	-2.0	2.1	2.6
Glucose	0.0	0.1	0.3	-0.4	0.1	0.2	0.1	-0.0	0.0	0.2	0.5
Heart weight	1.3	1.9	2.2	-1.4	-1.5	1.5	1.2	-1.3	-1.3	1.3	1.4
Delay discount hyperbolic model param	0.0	0.0	0.2	-0.3	-0.2	0.3	0.1	0.0	0.0	0.0	0.4
Intermittent access intake day 1-15 change	0.9	0.9	1.3	-1.1	-1.1	0.9	0.9	-0.8	-0.8	0.9	1.0
Intermittent access intake escalation	1.0	1.0	1.5	-1.2	-1.1	1.0	0.9	-0.8	-0.9	1.0	1.1
Intermittent access intake escalation 2	0.2	0.2	0.3	0.0	-0.6	0.2	0.4	-0.5	-0.5	0.5	0.0
Intermitt. access day 1 inactive lever presses	0.4	0.4	1.0	1.0	0.7	-0.6	-0.5	0.4	0.3	-0.4	-0.8
Intermitt. access day 15 inactive lever presses	0.3	0.4	1.2	-1.1	-0.7	0.6	0.5	-0.4	-0.2	0.2	0.7
Intermitt. access escalation Index	0.2	0.2	0.3	-0.3	-0.2	0.5	0.5	-0.6	-0.6	0.4	0.4
Intermittent access day 1 total infusions	1.9	2.2	3.1	-1.6	-1.8	1.5	1.5	-1.6	-1.3	1.4	1.2
Intermittent access day 15 total infusions	2.5	2.8	4.2	-1.9	-2.0	1.7	1.6	-1.6	-1.4	1.4	1.6
Intermittent access terminal intake (last 3 days)	2.2	2.4	3.6	-1.7	-1.9	1.5	1.6	-1.5	-1.3	1.4	1.3
Intermittent access total infusions	1.9	2.1	2.9	-1.5	-1.7	1.4	1.5	-1.5	-1.3	1.3	1.2
Intermittent access day 1 locomotion	0.2	0.2	0.7	-0.8	-0.5	0.5	0.3	-0.4	-0.1	0.2	0.6
Intermittent access day 15 total locomotion	1.7	1.8	3.0	-1.7	-1.2	1.4	1.1	-1.3	-1.1	1.2	1.6
Intermittent access total locomotion	1.1	1.3	2.2	-1.5	-1.3	1.1	1.1	-1.1	-0.9	1.0	1.1
Intermittent access standard deviation	0.0	0.0	0.2	-0.1	-0.1	0.1	0.2	-0.4	-0.1	0.3	0.0
Left kidney weight	0.7	2.1	3.6	-0.6	-1.4	1.1	1.7	-1.9	-1.8	1.9	0.1
Right kidney weight	0.4	1.0	1.8	-0.2	-0.9	0.7	1.2	-1.3	-1.2	1.3	-0.1
Cocaine induced anxiety	3.1	3.6	3.9	1.9	2.0	-1.9	-2.0	1.8	1.9	-2.0	-1.8
Post-drug Anxiety	0.8	0.9	1.8	1.0	0.5	-1.1	-0.7	1.1	0.8	-0.8	-1.3
Baseline Anxiety	2.2	2.3	3.3	-1.5	-1.8	1.4	1.7	-1.2	-1.6	1.7	1.0
Tail length	2.6	7.7	13.2	-1.7	-3.1	1.8	3.5	-3.1	-3.3	3.6	-0.0
Length with tail	1.0	3.8	6.4	-1.0	-2.4	1.0	2.5	-2.1	-2.2	2.5	-0.7
Length without tail	0.1	0.3	0.5	0.3	0.2	-0.5	-0.5	0.7	0.7	-0.6	-0.6
Times rat made contact with spout	0.2	0.2	0.8	0.6	0.4	-0.6	-0.1	0.3	0.3	0.0	-0.9
Lifetime Intake	2.4	2.8	3.8	-1.8	-1.9	1.7	1.7	-1.6	-1.5	1.5	1.5
Liver weight, left	0.7	1.2	3.4	1.8	0.6	-1.1	-0.5	0.3	0.4	-0.5	-1.8
Liver weight, right	1.2	2.0	7.1	2.2	0.5	-1.6	-0.6	0.6	0.6	-0.6	-2.7
Locomotor activity	0.4	0.6	1.0	-1.0	-0.7	0.9	0.7	-0.8	-0.7	0.6	0.7
Locomotor testing distance	2.0	3.3	4.0	-1.9	-1.8	1.9	1.9	-2.0	-1.8	1.8	1.4
Locomotor testing rearing	0.8	1.3	2.1	-0.8	-1.4	0.8	1.4	-1.3	-1.2	1.2	0.1
Locomotion in novel chamber	0.1	0.2	0.9	-0.2	0.3	0.5	-0.2	-0.2	-0.2	-0.2	1.0
Locomotion in novel chamber post-restriction	2.2	2.6	4.6	-1.8	-1.4	1.8	1.3	-1.4	-1.5	1.4	2.2
Fecal boli incidents, locomotor time 1	0.3	0.3	1.1	0.1	-0.1	0.8	0.1	-0.6	-0.6	0.1	1.0
Change in fecal boli incidents, locomotor task	0.8	0.7	1.1	0.7	0.9	-1.0	-0.7	0.9	0.9	-0.7	-1.0
Time >=10cm from walls, locomotor time 1	1.4	1.4	2.1	-1.4	-0.8	1.4	0.9	-1.2	-1.2	0.8	1.4
Bouts of movement, locomotor time 1	0.2	0.2	0.6	-0.5	-0.8	0.5	0.3	-0.4	-0.4	0.3	0.4
Total resting periods, locomotor time 1	0.1	0.1	0.3	-0.3	-0.4	0.3	-0.0	-0.1	-0.1	-0.1	0.5
Rest time, locomotor task time 1	0.1	0.1	0.1	-0.2	-0.1	0.0	-0.3	0.3	0.3	-0.4	0.3
Distance moved, locomotor task time 1	0.2	0.2	0.3	0.2	-0.1	0.0	0.4	-0.6	-0.6	0.6	-0.4
Vertical activity count, locomotor time 1	0.3	0.3	0.6	-0.2	-0.4	0.4	0.7	-0.8	-0.8	0.7	-0.1
Time >=10cm from walls, locomotor time 2	2.0	2.1	2.6	-1.6	-1.5	1.5	1.6	-1.5	-1.5	1.3	1.0
Bouts of movement, locomotor time 2	0.3	0.3	0.6	0.1	-0.5	0.2	0.8	-0.8	-0.8	0.5	-0.6
Total resting periods, locomotor time 2	0.2	0.2	0.7	0.5	-0.1	-0.2	0.4	-0.4	-0.4	0.1	-0.8
Rest time, locomotor task time 2	3.3	3.8	4.3	1.9	1.9	-2.0	-2.0	2.1	2.1	-2.1	-1.7
Distance moved, locomotor task time 2	3.9	4.5	5.6	-1.9	-2.4	2.1	2.3	-2.2	-2.2	2.3	1.5
Vertical activity count, locomotor time 2	1.3	1.4	2.2	-0.7	-1.2	1.1	1.4	-1.5	-1.5	1.3	0.4
Light reinforcement 1	3.4	6.1	7.9	2.6	2.8	-2.5	-2.5	2.4	2.5	-2.3	-2.1
Light reinforcement 2	0.5	0.7	1.6	0.3	1.3	-0.6	-0.9	1.0	1.0	-0.7	0.1
Bone: marrow area	1.1	2.4	3.6	-1.0	-1.5	1.3	1.8	-1.9	-1.9	1.9	0.5
Bone: maximum diameter	2.3	4.1	5.4	-1.9	-2.3	1.9	2.2	-2.1	-2.1	2.2	1.2
Bone: maximum force	0.0	0.0	0.1	-0.1	0.0	0.2	0.3	-0.2	-0.2	0.1	-0.1
Bone: maximum moment	0.1	0.2	0.3	-0.4	-0.2	0.4	0.5	-0.5	-0.5	0.4	0.2
Mean time between licks in bursts	5.6	7.8	11.0	-2.0	-3.3	2.5	3.2	-3.2	-3.2	3.1	1.0
Mean num. licks in bursts	4.6	5.5	7.0	-2.6	-2.1	2.6	2.2	-2.2	-2.2	2.2	2.5
Cd content in liver	0.5	0.5	1.2	1.1	0.5	-0.9	-0.5	0.5	0.3	-0.3	-1.0
Co content in liver	2.1	2.4	3.6	-1.3	-1.9	1.4	1.8	-1.7	-1.7	1.7	0.7
Cu content in liver	1.1	1.3	2.1	-0.7	-1.5	0.9	1.3	-1.3	-1.3	1.4	0.3
Fe content in liver	0.0	0.0	0.1	0.1	0.1	-0.1	0.0	0.1	0.1	0.0	-0.2
K content in liver	0.2	0.2	0.6	0.6	0.2	-0.5	-0.2	0.3	0.3	-0.2	-0.8
Mg content in liver	0.2	0.2	0.2	-0.4	-0.4	0.4	0.5	-0.5	-0.4	0.5	0.3
Mn content in liver	2.0	2.2	3.0	1.1	1.7	-1.3	-1.7	1.7	1.7	-1.7	-0.6
Na content in liver	0.4	0.5	1.0	-1.0	-0.5	0.7	0.6	-0.4	-0.4	0.7	0.9
Rb content in liver	1.1	1.4	1.7	-1.3	-1.1	1.1	1.3	-1.2	-1.1	1.3	0.9
Se content in liver	4.0	4.9	5.6	2.2	2.3	-2.2	-2.3	2.4	2.4	-2.3	-1.7
Sr content in liver	0.1	0.1	0.3	-0.2	0.1	0.1	-0.2	0.2	0.2	-0.1	0.5
Zn content in liver	5.1	5.6	6.8	-2.2	-2.1	2.5	2.3	-2.6	-2.6	2.4	2.2
Bone: minimum diameter	0.6	1.1	1.9	-0.4	-1.3	0.6	1.4	-1.2	-1.2	1.4	-0.4
Time in familiar zone, hab. session 1	0.0	0.0	0.1	-0.0	-0.0	0.0	0.2	-0.1	-0.2	0.3	-0.2
Time in novel zone, hab. session 1	0.3	0.3	0.5	0.7	0.1	-0.6	-0.6	0.5	0.6	-0.6	-0.6
Total zone transitions, hab. session 1	0.2	0.2	0.8	-0.9	-0.4	0.2	0.0	0.2	0.2	0.0	0.7
Total locomotion distance, hab. session 1	0.6	0.8	2.9	1.3	0.3	-1.0	-0.3	0.5	0.4	-0.4	-1.7
Locomotion velocity, hab. session 1	0.3	0.4	1.8	1.0	0.2	-0.7	-0.2	0.3	0.2	-0.3	-1.4
Time in familiar zone, hab. session 2	1.6	1.7	2.2	-1.0	-1.3	1.4	1.5	-1.5	-1.5	1.3	0.9
Time in novel zone, hab. session 2	0.4	0.4	0.7	0.4	0.6	-0.6	-0.8	0.8	0.8	-0.7	-0.2
Total zone transitions, hab. session 2	2.0	2.6	5.6	-2.4	-1.7	1.6	1.4	-1.1	-1.1	1.3	1.9
Total locomotion distance, hab. session 2	0.2	0.3	0.8	0.1	-0.8	0.0	0.6	-0.4	-0.5	0.5	-0.9
Locomotion velocity, hab. session 2	0.2	0.3	1.2	0.2	-0.7	-0.2	0.6	-0.3	-0.4	0.4	-1.1
Novel to familiar place preference ratio	0.1	0.1	0.3	-0.5	-0.5	0.3	0.3	-0.2	-0.3	0.0	-0.0
Novelty place preference	0.1	0.1	0.3	-0.5	-0.6	0.3	0.3	-0.2	-0.3	0.1	0.0
Time in novel zone, NPP test	0.3	0.3	0.6	-0.7	-0.8	0.5	0.5	-0.4	-0.4	0.2	0.2
Total zone transitions, NPP test	0.3	0.4	1.0	-1.0	-0.7	0.6	0.4	-0.3	-0.3	0.4	1.0
Total locomotion distance, NPP test	0.3	0.5	1.8	1.1	0.1	-0.8	-0.3	0.2	0.1	-0.2	-1.4
Locomotion velocity, NPP test	0.6	0.9	2.6	1.4	0.4	-1.1	-0.6	0.5	0.5	-0.5	-1.6
Intraocular pressure	0.1	0.2	1.1	-0.2	0.2	0.4	-0.2	-0.2	-0.2	0.1	1.1
Delta distance traveled before/after self-admin	2.3	2.5	4.4	-2.1	-1.8	1.7	1.5	-1.0	-1.1	1.3	1.8
Delta ambulatory time before/after self-admin	2.0	2.2	4.5	-2.1	-1.5	1.7	1.3	-0.9	-0.9	1.1	2.0
Parametrial fat weight	0.7	1.3	2.9	1.7	0.8	-1.4	-0.9	0.8	0.8	-0.6	-1.5
Pavlov. Cond. lever latency	1.6	2.0	2.4	1.4	1.6	-1.4	-1.4	1.5	1.4	-1.4	-1.2
Pavlov. Cond. magazine entry latency	3.7	4.7	5.3	-2.2	-2.2	2.2	2.3	-2.3	-2.2	2.3	1.7
Pavlov. Cond. change in total contacts	1.9	2.0	2.3	-1.4	-1.5	1.4	1.5	-1.5	-1.4	1.5	1.1
Pavlov. Cond. index score	3.7	4.7	5.3	-2.1	-2.3	2.1	2.3	-2.3	-2.2	2.3	1.7
Pavlov. Cond. latency score	3.6	4.6	5.1	-2.1	-2.2	2.1	2.2	-2.3	-2.1	2.2	1.7
Pavlov. Cond. lever contacts	1.6	1.9	2.4	-1.2	-1.5	1.3	1.4	-1.5	-1.4	1.5	1.0
Pavlov. Cond. magazine entry number	4.4	5.4	5.8	2.4	2.4	-2.4	-2.4	2.3	2.3	-2.4	-2.1
Pavlov. Cond. intertrial magazine entries	1.0	1.2	1.7	0.9	1.1	-1.1	-1.1	1.3	1.2	-1.1	-0.9
Pavlov. Cond. lever-magazine prob. diff.	3.1	3.8	4.4	-1.9	-2.0	1.9	2.1	-2.0	-2.0	2.1	1.6
Pavlov. Cond. response bias	1.6	2.0	2.5	-1.3	-1.6	1.3	1.5	-1.5	-1.4	1.5	1.0
Pavlov. Cond. lever latency	21.9	29.6	32.5	5.5	5.7	-5.5	-5.5	5.5	5.5	-5.5	-4.6
Pavlov. Cond. magazine entry latency	4.5	5.3	6.4	-2.5	-1.9	2.5	2.2	-2.2	-2.2	2.2	2.4
Pavlov. Cond. change in total contacts	17.8	24.5	28.9	-5.4	-5.2	5.0	5.0	-4.8	-4.8	4.9	4.4
Pavlov. Cond. index score	16.9	21.7	23.1	-4.8	-4.6	4.8	4.7	-4.7	-4.7	4.7	4.1
Pavlov. Cond. latency score	15.1	18.8	20.1	-4.5	-4.3	4.5	4.4	-4.4	-4.4	4.3	3.9
Pavlov. Cond. lever contacts	23.0	31.5	34.4	-5.7	-5.9	5.7	5.7	-5.7	-5.7	5.7	4.8
Pavlov. Cond. magazine entry number	8.5	10.4	13.0	3.6	2.9	-3.4	-3.1	3.1	3.1	-3.1	-3.3
Pavlov. Cond. intertrial magazine entries	0.2	0.2	0.4	0.2	-0.6	-0.0	0.6	-0.4	-0.4	0.6	-0.6
Pavlov. Cond. lever-magazine prob. diff.	15.8	20.1	21.2	-4.6	-4.4	4.6	4.6	-4.6	-4.6	4.6	3.9
Pavlov. Cond. response bias	23.0	31.3	33.7	-5.8	-5.7	5.7	5.7	-5.6	-5.6	5.6	4.9
Time in closed arm before self-admin	2.2	2.5	6.2	-2.5	-1.5	1.8	1.0	-0.9	-0.5	0.8	2.4
Time in closed arm after self-admin	1.0	1.0	1.8	0.6	0.8	-0.8	-1.2	1.0	1.3	-1.3	-0.5
Time in open arm before self-admin	6.4	6.9	11.2	3.3	2.9	-2.8	-2.4	2.3	2.0	-2.3	-2.7
Time in open arm after self-admin	0.3	0.3	0.8	0.5	-0.1	0.1	0.5	-0.6	-0.9	0.7	-0.3
Bone: periosteal estimation	1.3	2.6	3.6	-1.2	-1.7	1.4	1.9	-1.9	-1.9	1.9	0.7
Bone: periosteal perimeter	1.6	2.7	3.4	-1.4	-1.8	1.5	1.8	-1.8	-1.8	1.8	0.9
Bone: post-yield work	0.1	0.2	0.3	-0.4	-0.5	0.5	0.4	-0.5	-0.5	0.3	0.4
Progressive ratio test 1 active lever presses	0.0	0.0	0.1	-0.2	-0.1	-0.1	-0.0	0.1	0.3	-0.0	-0.0
Progressive ratio test 1 breakpoint	0.0	0.0	0.0	-0.2	-0.2	-0.1	0.1	0.1	0.2	0.1	-0.1
Progressive ratio test 1 inactive lever presses	0.6	0.7	0.9	-0.8	-0.9	0.8	0.8	-1.0	-0.8	0.8	0.7
Progressive ratio test 2 active lever presses	1.3	1.4	2.5	-1.2	-1.6	1.1	1.3	-1.2	-1.1	1.2	0.8
Progressive ratio test 2 breakpoint	1.4	1.5	2.6	-1.3	-1.6	1.1	1.3	-1.3	-1.1	1.2	0.8
Progressive ratio test 2 inactive lever presses	1.1	1.3	2.2	-1.5	-1.1	1.2	1.0	-1.1	-1.0	0.8	1.3
Incentive Sensitization - Responses	2.6	2.6	3.7	-1.4	-1.9	1.5	1.8	-1.7	-1.7	1.7	1.0
Incentive Sensitization - Breakpoint	2.3	2.3	3.3	-1.4	-1.8	1.4	1.7	-1.6	-1.6	1.5	1.0
Sum of active levers in priming session hrs 5-6	0.2	0.2	0.5	-0.2	0.1	-0.3	-0.2	0.7	0.7	-0.4	-0.1
Progressive ratio	0.1	0.1	0.2	-0.5	0.4	0.1	-0.2	0.2	0.2	-0.0	0.5
Food seeking constrained by brief footshock	1.2	1.5	2.8	-1.0	-1.7	0.9	1.4	-1.3	-1.1	1.4	0.4
Seeking ratio, punishment vs. effort	1.0	1.2	2.3	-0.2	-1.5	0.7	1.3	-1.3	-1.3	1.2	-0.1
Retroperitoneal fat weight	2.1	7.0	21.2	3.7	1.5	-3.2	-1.5	1.5	1.6	-1.1	-4.6
Reaction time number correct	0.1	0.2	0.5	-0.6	0.1	0.3	-0.2	0.5	0.3	-0.4	0.7
Reaction time mean minus median	0.7	0.9	1.6	-0.7	-1.3	0.9	1.0	-1.1	-1.1	1.0	0.5
Reaction time mean minus median AUC	1.0	1.3	1.7	-1.1	-1.3	1.3	1.1	-1.2	-1.2	1.0	1.0
Reaction time num false alarms	2.5	3.5	5.4	2.3	1.5	-2.0	-1.6	1.6	1.7	-1.7	-2.2
Reaction time num false alarms AUC	1.6	2.2	3.5	1.9	1.2	-1.5	-1.4	1.3	1.4	-1.5	-1.6
Reaction time trials correct on left	0.1	0.2	0.5	-0.6	0.1	0.3	-0.2	0.5	0.3	-0.4	0.7
Reaction time trials on left	0.1	0.2	0.5	-0.6	0.1	0.3	-0.3	0.5	0.3	-0.4	0.7
Reaction time mean	0.9	1.3	2.5	1.5	0.8	-1.2	-0.9	0.9	0.9	-1.0	-1.6
Reaction time mean AUC	1.2	1.6	2.4	1.5	0.9	-1.3	-1.1	1.2	1.1	-1.2	-1.6
Median of all reaction times	1.8	2.5	3.8	1.9	1.4	-1.6	-1.4	1.4	1.4	-1.5	-1.9
Reaction time omissions	0.4	0.5	0.9	0.9	0.6	-0.8	-0.6	0.5	0.7	-0.6	-0.9
Reaction time false alarm rate	1.7	2.3	4.7	2.2	1.2	-1.7	-1.3	1.1	1.2	-1.3	-2.0
Reaction time premature initiation rate	1.6	2.1	3.5	-0.6	-1.6	1.1	1.7	-1.8	-1.7	1.9	0.2
Reaction time premature initiations	1.2	1.7	2.2	-1.0	-1.4	1.2	1.4	-1.4	-1.4	1.5	0.7
Std. dev. reaction times	0.3	0.4	0.7	0.3	-0.8	0.1	0.6	-0.7	-0.7	0.6	-0.6
Reaction time trials completed	0.1	0.2	0.5	-0.6	0.1	0.3	-0.3	0.5	0.3	-0.4	0.7
Reaction time trials AUC	0.1	0.1	0.3	-0.5	0.0	0.2	-0.2	0.5	0.3	-0.4	0.6
Run reversals in cocaine runway, females	0.6	0.5	2.2	0.7	-0.5	-0.6	0.5	-0.3	-0.3	0.7	-1.5
Run reversals in cocaine runway, males	0.1	0.1	0.7	-0.0	0.8	-0.2	-0.4	0.1	0.3	-0.3	-0.0
Latency to leave start box in cocaine runway	2.1	2.3	3.5	1.8	1.2	-1.8	-1.3	1.5	1.2	-1.1	-1.9
Latency to leave start box in cocaine runway, F	1.5	1.7	3.8	1.7	0.7	-1.6	-1.0	1.1	0.9	-0.7	-1.9
Latency to leave start box in cocaine runway, M	0.5	0.5	0.8	0.6	0.9	-0.6	-0.8	0.9	0.7	-0.7	-0.2
Std. dev. time between licks in bursts	1.4	1.7	2.6	-0.3	-1.6	0.9	1.5	-1.6	-1.6	1.5	-0.2
Total sessions with >9 infusions	4.1	4.5	6.1	-2.5	-2.1	2.2	2.0	-2.0	-1.9	1.9	2.3
Short access day 1 total inactive lever presses	0.0	0.0	0.1	-0.2	-0.3	0.0	0.0	0.2	0.1	-0.1	0.0
Short access day 10 total inactive lever presses	0.2	0.3	0.4	0.7	0.5	-0.4	-0.6	0.5	0.4	-0.6	-0.3
Short access day 1 total infusions	3.5	3.8	4.7	-1.9	-2.2	2.0	2.1	-2.0	-1.9	1.9	1.6
Short access day 10 total infusions	2.5	2.8	4.0	-1.7	-2.0	1.5	1.8	-1.7	-1.5	1.7	1.2
Short access total infusions	2.1	2.3	3.0	-1.5	-1.7	1.5	1.7	-1.5	-1.4	1.5	1.2
Short access day 1 locomotion	1.7	1.8	4.2	-1.6	-0.7	1.6	1.0	-1.2	-1.2	1.0	2.0
Short access day 10 total locomotion	0.3	0.3	0.4	-0.6	-0.6	0.5	0.6	-0.7	-0.5	0.6	0.3
Short access total locomotion	0.2	0.2	0.4	-0.6	-0.3	0.5	0.4	-0.5	-0.4	0.5	0.6
One hour access (0.3 mA shock)	2.5	3.0	3.8	-1.5	-2.0	1.7	1.7	-1.9	-1.8	1.6	1.4
Compulsive drug intake	0.4	0.4	1.3	0.5	1.1	-0.3	-0.8	0.6	0.4	-0.7	0.2
One hour access (shock baseline)	2.5	2.9	4.6	-1.6	-2.1	1.6	1.8	-1.8	-1.7	1.7	1.1
Social response proportion	0.3	0.4	1.1	1.1	0.3	-0.6	-0.3	0.3	0.3	-0.3	-1.0
Social responses	0.3	0.4	1.9	0.9	-0.1	-0.6	0.2	0.1	-0.0	-0.1	-1.4
Social time	2.6	3.4	4.6	1.6	1.5	-1.9	-1.9	2.1	2.1	-2.1	-1.5
Soleus weight	0.2	0.7	2.7	1.4	-0.2	-0.6	0.1	-0.4	-0.4	0.3	-1.7
Bone: stiffness	0.2	0.3	1.3	0.7	0.3	-0.6	-0.2	0.2	0.2	-0.3	-1.1
Tibialis anterior weight	0.1	0.2	0.5	0.0	-0.3	0.2	0.6	-0.7	-0.7	0.5	-0.4
Time to tail flick, vehicle, before self-admin	0.1	0.1	0.4	-0.6	-0.2	0.1	0.2	0.3	0.3	0.1	0.2
Time to tail flick, vehicle, after self-admin	3.3	3.5	5.2	-2.2	-1.8	2.1	1.6	-1.7	-1.6	1.7	2.3
Time to tail flick, test, before self-admin	1.0	1.0	1.8	-1.1	-1.4	0.7	1.1	-0.9	-0.8	1.2	0.5
Time to tail flick, test, after self-admin	0.8	0.9	1.6	-0.5	-1.3	0.6	1.2	-0.9	-1.1	1.2	-0.2
Delta time to tail flick, vehicle, before/after SA	1.9	1.8	3.0	-1.2	-1.0	1.5	1.0	-1.5	-1.3	1.2	1.7
Delta time to tail flick, test, before/after SA	0.3	0.3	0.6	0.8	0.4	-0.5	-0.5	0.5	0.3	-0.4	-0.7
Tibia length	1.6	4.4	7.6	-2.8	-1.2	2.5	1.8	-1.9	-1.9	1.6	2.7
Ambulatory time before self-admin	1.9	2.0	2.2	1.5	1.3	-1.5	-1.4	1.3	1.4	-1.5	-1.3
Ambulatory time after self-admin	0.3	0.3	0.7	-0.7	0.1	0.1	-0.3	0.7	0.9	-0.6	0.7
Bone: tissue strength	0.5	0.5	0.9	-0.1	0.9	-0.2	-0.8	0.8	0.8	-0.8	0.5
Total heroin consumption	0.4	0.5	1.4	-1.2	-0.7	0.8	0.6	-0.3	-0.4	0.4	0.8
Bone: trabecular number	0.9	1.4	2.0	0.7	1.3	-1.1	-1.3	1.4	1.4	-1.2	-0.4
Bone: trabecular spacing	0.9	1.2	1.4	-1.1	-0.8	1.2	1.1	-1.1	-1.2	1.0	1.2
Bone: trabecular thickness	0.2	0.2	0.6	0.4	0.2	-0.5	-0.3	0.5	0.6	-0.4	-0.8
Bone: trabecular tissue density	1.1	1.5	5.4	1.6	0.2	-1.4	-0.6	0.8	0.8	-0.7	-2.3
Water consumed over 24 hours	0.6	0.8	1.2	0.6	1.1	-0.8	-0.9	1.0	1.0	-0.9	-0.5
Number of responses in last shaping day	0.2	0.2	0.5	-0.3	-0.5	0.4	0.6	-0.7	-0.5	0.5	0.0