Progressive ratio

Progressive ratio, i.e. food-seeking constrained by escalating effort schedule. The last successfully completed ratio or shock intensity endured before timeout. Animals are food restricted to 85% of initial body weight, trained to lever-press for food pellets (45 mg) until stable response rates were reached, then tested either on the progressive ratio (PR) task with progressively increasing effort requirements (lever-presses required per pellet) or progressively increasing punishment (i.e., a foot-shock of increasing intensity presented 1 s after food pellet delivery, whose magnitude increases ~25% every 3 trials). In the PR task, rats time out if 2 min passed without a lever press. In the punishment task, a timeout is defined by three consecutive trials with >30 s passing without a lever press. For both tasks, the break point is the last successfully completed ratio or shock intensity endured before timeout.

Tags: Behavior · Motivation

Project: u01_tom_jhou

0 loci · 0 genes with independent associations · 0 total associated genes

Significant Loci

# Chr Start pos End pos # assoc genes # joint models Best TWAS P Best GWAS P Cond GWAS P Joint genes

Pleiotropic Associations

Trait Chi2 ratio # genes+ # genes++ % genes++ Corr Corr P Genes

Associations by panel

Tissue RNA modality # hits % hits/tests Avg chisq
Adipose alternative polyA 0 0 1.15
Adipose alternative TSS 0 0 1.08
Adipose gene expression 0 0 1.1
Adipose isoform ratio 0 0 1.19
Adipose intron excision ratio 0 0 1.21
Adipose mRNA stability 0 0 1.14
BLA alternative polyA 0 0 1.18
BLA alternative TSS 0 0 1.16
BLA gene expression 0 0 1.15
BLA isoform ratio 0 0 1.17
BLA intron excision ratio 0 0 1.17
BLA mRNA stability 0 0 1.09
Brain alternative polyA 0 0 1.12
Brain alternative TSS 0 0 1.14
Brain gene expression 0 0 1.12
Brain isoform ratio 0 0 1.11
Brain intron excision ratio 0 0 1.12
Brain mRNA stability 0 0 1.1
Eye alternative polyA 0 0 1.47
Eye alternative TSS 0 0 1.08
Eye gene expression 0 0 1.23
Eye isoform ratio 0 0 1.06
Eye intron excision ratio 0 0 1.22
Eye mRNA stability 0 0 1.19
IL alternative polyA 0 0 1.18
IL alternative TSS 0 0 1.2
IL gene expression 0 0 1.16
IL isoform ratio 0 0 1.26
IL intron excision ratio 0 0 1.35
IL mRNA stability 0 0 1.07
LHb alternative polyA 0 0 1.18
LHb alternative TSS 0 0 1.48
LHb gene expression 0 0 1.17
LHb isoform ratio 0 0 1.22
LHb intron excision ratio 0 0 1.41
LHb mRNA stability 0 0 1.18
Liver alternative polyA 0 0 1.18
Liver alternative TSS 0 0 1.27
Liver gene expression 0 0 1.15
Liver isoform ratio 0 0 1.19
Liver intron excision ratio 0 0 1.15
Liver mRNA stability 0 0 1.11
NAcc alternative polyA 0 0 1.1
NAcc alternative TSS 0 0 1.22
NAcc gene expression 0 0 1.13
NAcc isoform ratio 0 0 1.17
NAcc intron excision ratio 0 0 1.19
NAcc mRNA stability 0 0 1.12
OFC alternative polyA 0 0 1.19
OFC alternative TSS 0 0 1.07
OFC gene expression 0 0 1.19
OFC isoform ratio 0 0 1.16
OFC intron excision ratio 0 0 1.48
OFC mRNA stability 0 0 1.05
PL alternative polyA 0 0 1.16
PL alternative TSS 0 0 1.11
PL gene expression 0 0 1.13
PL isoform ratio 0 0 1.16
PL intron excision ratio 0 0 1.24
PL mRNA stability 0 0 1.09
pVTA alternative polyA 0 0 1.25
pVTA alternative TSS 0 0 1.18
pVTA gene expression 0 0 1.15
pVTA isoform ratio 0 0 1.21
pVTA intron excision ratio 0 0 1.27
pVTA mRNA stability 0 0 1.09
RMTg alternative polyA 0 0 1.34
RMTg alternative TSS 0 0 1.23
RMTg gene expression 0 0 1.19
RMTg isoform ratio 0 0 1.33
RMTg intron excision ratio 0 0 1.21
RMTg mRNA stability 0 0 1.21