Progressive ratio

Progressive ratio, i.e. food-seeking constrained by escalating effort schedule. The last successfully completed ratio or shock intensity endured before timeout. Animals are food restricted to 85% of initial body weight, trained to lever-press for food pellets (45 mg) until stable response rates were reached, then tested either on the progressive ratio (PR) task with progressively increasing effort requirements (lever-presses required per pellet) or progressively increasing punishment (i.e., a foot-shock of increasing intensity presented 1 s after food pellet delivery, whose magnitude increases ~25% every 3 trials). In the PR task, rats time out if 2 min passed without a lever press. In the punishment task, a timeout is defined by three consecutive trials with >30 s passing without a lever press. For both tasks, the break point is the last successfully completed ratio or shock intensity endured before timeout.

Tags: Behavior · Motivation

Project: u01_tom_jhou

3 loci · 3 genes with independent associations · 3 total associated genes

Significant Loci

#	Chr	Start pos	End pos	# assoc genes	# joint models	Best TWAS P	Best GWAS P	Cond GWAS P	Joint genes
1	chr7	92127461	93066096	1	1	3.37e-17	6.73e-01	1.00e+00	Ndufb9
2	chr9	83390749	84777604	1	1	0.00e+00	1.60e-01	1.00e+00	Retreg2
3	chr17	61510864	62906219	1	1	4.58e-08	9.99e-02	6.31e-02	Ccny

Pleiotropic Associations

Trait	Chi² ratio	# genes⁺	# genes⁺⁺	% genes⁺⁺	Corr P	Genes
BMI with tail	439.52	2	2	66.7	1e+00	Ndufb9 Retreg2
BMI without tail	19087.71	3	2	66.7	1e+00	Ccny Ndufb9 Retreg2
Body weight	8.77	2	1	33.3	1e+00	Ndufb9 Retreg2
Epididymis fat weight	12099.45	3	2	66.7	1e+00	Ccny Ndufb9 Retreg2
Glucose	273.97	2	1	33.3	1e+00	Ndufb9 Retreg2
Heart weight	1536.76	2	1	33.3	1e+00	Ndufb9 Retreg2
Left kidney weight	18352.54	3	2	66.7	1e+00	Ccny Ndufb9 Retreg2
Right kidney weight	13473.5	3	3	100	1e+00	Ccny Ndufb9 Retreg2
Tail length	14460.46	2	1	33.3	1e+00	Ndufb9 Retreg2
Length with tail	746.74	2	2	66.7	1e+00	Ndufb9 Retreg2
Length without tail	15749.58	3	1	33.3	1e+00	Ccny Ndufb9 Retreg2
Liver weight, left	1166.4	3	1	33.3	1e+00	Ccny Ndufb9 Retreg2
Liver weight, right	26.54	2	1	33.3	1e+00	Ndufb9 Retreg2
Parametrial fat weight	181.56	1	1	33.3	1e+00	Retreg2
Retroperitoneal fat weight	3938.69	1	1	33.3	1e+00	Retreg2
Intraocular pressure	5195.51	2	1	33.3	1e+00	Ndufb9 Retreg2
Extensor digitorum longus weight	1077.67	1	1	33.3	1e+00	Retreg2
Soleus weight	12.63	2	1	33.3	1e+00	Ndufb9 Retreg2
Tibialis anterior weight	1158.38	1	1	33.3	1e+00	Retreg2
Tibia length	385.43	2	1	33.3	1e+00	Ndufb9 Retreg2
Number of licking bursts	67424.86	1	1	33.3	1e+00	Retreg2
Food consumed during 24 hour testing period	17759.18	2	1	33.3	1e+00	Ccny Retreg2
Times rat made contact with spout	41.61	2	1	33.3	1e+00	Ndufb9 Retreg2
Mean time between licks in bursts	55817.09	2	1	33.3	1e+00	Ndufb9 Retreg2
Mean num. licks in bursts	56750.08	1	1	33.3	1e+00	Retreg2
Std. dev. time between licks in bursts	29750.31	1	1	33.3	1e+00	Retreg2
Water consumed over 24 hours	17087.99	2	1	33.3	1e+00	Ccny Retreg2
Patch foraging indifference point 0 sec	39171.5	1	1	33.3	1e+00	Retreg2
Patch foraging indifference point AUC	16721.56	3	2	66.7	1e+00	Ccny Ndufb9 Retreg2
Indifference point function ln k	18574.96	3	3	100	1e+00	Ccny Ndufb9 Retreg2
Indifference point function log k	18574.96	3	3	100	1e+00	Ccny Ndufb9 Retreg2
Patch foraging total patch changes 0 sec	41947.04	1	1	33.3	1e+00	Retreg2
Patch foraging total patch changes 12 sec	795.75	3	3	100	1e+00	Ccny Ndufb9 Retreg2
Patch foraging total patch changes 18 sec	13490.56	3	1	33.3	1e+00	Ccny Ndufb9 Retreg2
Patch foraging total patch changes 24 sec	24967.95	3	2	66.7	1e+00	Ccny Ndufb9 Retreg2
Patch foraging total patch changes 6 sec	2607.57	3	2	66.7	1e+00	Ccny Ndufb9 Retreg2
Patch foraging time to switch 0 sec	33254.99	2	2	66.7	1e+00	Ndufb9 Retreg2
Patch foraging water rate 0 sec	30219.01	2	1	33.3	1e+00	Ndufb9 Retreg2
Patch foraging water rate 12 sec	35330.95	2	2	66.7	1e+00	Ccny Retreg2
Patch foraging water rate 18 sec	16866.98	2	1	33.3	1e+00	Ndufb9 Retreg2
Patch foraging water rate 24 sec	1033.47	1	1	33.3	1e+00	Retreg2
Patch foraging water rate 6 sec	297.7	3	3	100	1e+00	Ccny Ndufb9 Retreg2
Locomotor activity	10.67	2	0	0	1e+00	Ccny Ndufb9
Locomotor testing distance	9235.62	3	2	66.7	1e+00	Ccny Ndufb9 Retreg2
Locomotor testing rearing	31701.02	2	1	33.3	1e+00	Ndufb9 Retreg2
Light reinforcement 1	33170.19	2	2	66.7	1e+00	Ccny Retreg2
Light reinforcement 2	12261.7	3	2	66.7	1e+00	Ccny Ndufb9 Retreg2
Reaction time number correct	21165.65	3	2	66.7	1e+00	Ccny Ndufb9 Retreg2
Reaction time mean minus median	59977.3	2	1	33.3	1e+00	Ndufb9 Retreg2
Reaction time mean minus median AUC	62002.11	2	2	66.7	1e+00	Ndufb9 Retreg2
Reaction time num false alarms	7680.85	2	1	33.3	1e+00	Ccny Retreg2
Reaction time num false alarms AUC	17510.62	2	1	33.3	1e+00	Ccny Retreg2
Reaction time trials correct on left	21165.65	3	2	66.7	1e+00	Ccny Ndufb9 Retreg2
Reaction time trials on left	20303.42	3	2	66.7	1e+00	Ccny Ndufb9 Retreg2
Reaction time mean	29724.21	1	1	33.3	1e+00	Retreg2
Reaction time mean AUC	38768	1	1	33.3	1e+00	Retreg2
Median of all reaction times	7893.84	1	1	33.3	1e+00	Retreg2
Reaction time omissions	4186.04	2	1	33.3	1e+00	Ndufb9 Retreg2
Reaction time false alarm rate	108.16	2	1	33.3	1e+00	Ndufb9 Retreg2
Reaction time premature initiation rate	9733.76	1	1	33.3	1e+00	Retreg2
Reaction time premature initiations	26873.53	2	1	33.3	1e+00	Ndufb9 Retreg2
Std. dev. reaction times	30435.18	2	1	33.3	1e+00	Ndufb9 Retreg2
Reaction time trials completed	20303.42	3	2	66.7	1e+00	Ccny Ndufb9 Retreg2
Reaction time trials AUC	20718.27	3	1	33.3	1e+00	Ccny Ndufb9 Retreg2
Social response proportion	8777.03	1	1	33.3	1e+00	Retreg2
Social responses	425.67	3	1	33.3	1e+00	Ccny Ndufb9 Retreg2
Social time	11650.06	1	1	33.3	1e+00	Retreg2
Conditioned locomotion	1400.08	1	1	33.3	1e+00	Retreg2
Cocaine response after cond. corrected	19128.47	1	1	33.3	1e+00	Retreg2
Cocaine response after cond. not corrected	18571.31	1	1	33.3	1e+00	Retreg2
Cocaine response before conditioning	655.41	1	1	33.3	1e+00	Retreg2
Saline control response	3160.68	1	1	33.3	1e+00	Retreg2
Condit. Reinf. active minus inactive responses	14521.56	1	1	33.3	1e+00	Retreg2
Condit. Reinf. active-inactive response ratio	14360.59	2	1	33.3	1e+00	Ndufb9 Retreg2
Condit. Reinf. active responses	2302.04	1	1	33.3	1e+00	Retreg2
Condit. Reinf. inactive responses	10889.7	1	1	33.3	1e+00	Retreg2
Condit. Reinf. lever presses	1935.17	2	1	33.3	1e+00	Ndufb9 Retreg2
Condit. Reinf. lever reinforcers received	469.54	1	1	33.3	1e+00	Retreg2
Pavlov. Cond. lever latency	2531.81	1	1	33.3	1e+00	Retreg2
Pavlov. Cond. magazine entry latency	13282.18	1	1	33.3	1e+00	Retreg2
Pavlov. Cond. change in total contacts	19909.31	2	1	33.3	1e+00	Ndufb9 Retreg2
Pavlov. Cond. index score	12744.53	1	1	33.3	1e+00	Retreg2
Pavlov. Cond. latency score	16150.81	1	1	33.3	1e+00	Retreg2
Pavlov. Cond. lever contacts	5331.08	1	1	33.3	1e+00	Retreg2
Pavlov. Cond. magazine entry number	4012.39	1	1	33.3	1e+00	Retreg2
Pavlov. Cond. intertrial magazine entries	34989.79	1	1	33.3	1e+00	Retreg2
Pavlov. Cond. lever-magazine prob. diff.	11800.43	1	1	33.3	1e+00	Retreg2
Pavlov. Cond. response bias	1164.95	1	1	33.3	1e+00	Retreg2
Conditioned reinforcement - actives	33617.26	3	2	66.7	1e+00	Ccny Ndufb9 Retreg2
Conditioned reinforcement - inactives	21639.27	3	2	66.7	1e+00	Ccny Ndufb9 Retreg2
Conditioned locomotion	3473.76	3	2	66.7	1e+00	Ccny Ndufb9 Retreg2
Intermittent access intake day 1-15 change	63939.81	2	1	33.3	1e+00	Ccny Retreg2
Intermittent access intake escalation	126068.82	1	1	33.3	1e+00	Retreg2
Intermittent access intake escalation 2	18103.13	2	2	66.7	1e+00	Ccny Retreg2
Intermitt. access day 1 inactive lever presses	60207.72	3	1	33.3	1e+00	Ccny Ndufb9 Retreg2
Intermitt. access day 15 inactive lever presses	61868.22	2	2	66.7	1e+00	Ndufb9 Retreg2
Intermitt. access escalation Index	46653.32	2	1	33.3	1e+00	Ndufb9 Retreg2
Intermittent access day 1 total infusions	66115.79	1	1	33.3	1e+00	Retreg2
Intermittent access day 15 total infusions	48731.91	1	1	33.3	1e+00	Retreg2
Intermittent access terminal intake (last 3 days)	24800.59	1	1	33.3	1e+00	Retreg2
Intermittent access total infusions	93.49	2	1	33.3	1e+00	Ccny Retreg2
Intermittent access day 1 locomotion	17487.55	2	1	33.3	1e+00	Ccny Retreg2
Intermittent access day 15 total locomotion	42786.58	2	2	66.7	1e+00	Ccny Retreg2
Intermittent access total locomotion	64.05	2	1	33.3	1e+00	Ndufb9 Retreg2
Intermittent access standard deviation	56992.22	2	2	66.7	1e+00	Ccny Retreg2
Cocaine induced anxiety	23063.21	3	2	66.7	1e+00	Ccny Ndufb9 Retreg2
Post-drug Anxiety	2390.18	2	2	66.7	1e+00	Ndufb9 Retreg2
Baseline Anxiety	11242.19	3	2	66.7	1e+00	Ccny Ndufb9 Retreg2
Lifetime Intake	834.23	2	1	33.3	1e+00	Ccny Retreg2
Incentive Sensitization - Responses	23798.01	3	2	66.7	1e+00	Ccny Ndufb9 Retreg2
Incentive Sensitization - Breakpoint	18436.14	3	2	66.7	1e+00	Ccny Ndufb9 Retreg2
Progressive ratio test 1 active lever presses	10671	3	1	33.3	1e+00	Ccny Ndufb9 Retreg2
Progressive ratio test 1 breakpoint	10109.49	3	1	33.3	1e+00	Ccny Ndufb9 Retreg2
Progressive ratio test 1 inactive lever presses	31117.61	2	2	66.7	1e+00	Ndufb9 Retreg2
Progressive ratio test 2 active lever presses	5096.01	3	1	33.3	1e+00	Ccny Ndufb9 Retreg2
Progressive ratio test 2 breakpoint	2856.35	3	1	33.3	1e+00	Ccny Ndufb9 Retreg2
Progressive ratio test 2 inactive lever presses	24171.88	3	1	33.3	1e+00	Ccny Ndufb9 Retreg2
Total sessions with >9 infusions	991.35	2	2	66.7	1e+00	Ccny Retreg2
Short access day 1 total inactive lever presses	13149.15	3	2	66.7	1e+00	Ccny Ndufb9 Retreg2
Short access day 10 total inactive lever presses	69442.46	2	2	66.7	1e+00	Ccny Retreg2
Short access day 1 total infusions	19232.26	2	2	66.7	1e+00	Ccny Retreg2
Short access day 10 total infusions	11359.78	2	2	66.7	1e+00	Ndufb9 Retreg2
Short access total infusions	4403.04	2	2	66.7	1e+00	Ccny Retreg2
Short access day 1 locomotion	8286	3	2	66.7	1e+00	Ccny Ndufb9 Retreg2
Short access day 10 total locomotion	88176.71	1	1	33.3	1e+00	Retreg2
Short access total locomotion	9343.18	2	1	33.3	1e+00	Ndufb9 Retreg2
Compulsive drug intake	9346.2	2	1	33.3	1e+00	Ndufb9 Retreg2
One hour access (0.3 mA shock)	781.33	3	1	33.3	1e+00	Ccny Ndufb9 Retreg2
One hour access (shock baseline)	54988.81	1	1	33.3	1e+00	Retreg2
Number of responses in last shaping day	6821.53	2	1	33.3	1e+00	Ccny Retreg2
Context. condit. distance diff. score	212.47	1	1	33.3	1e+00	Retreg2
Locomotion velocity, session 1	1769.63	2	1	33.3	1e+00	Ndufb9 Retreg2
Locomotion distance, session 1	516.6	2	1	33.3	1e+00	Ccny Retreg2
Locomotion velocity, session 2	2158.08	1	1	33.3	1e+00	Retreg2
Locomotion distance, session 2	258.34	2	1	33.3	1e+00	Ccny Retreg2
Locomotion velocity, session 3	507.49	1	1	33.3	1e+00	Retreg2
Locomotion distance, session 3	4009.46	1	1	33.3	1e+00	Retreg2
Stereotopy head waving bouts, day 3	1361.96	1	1	33.3	1e+00	Retreg2
Stereotopy head waving duration, day 3	2872.44	1	1	33.3	1e+00	Retreg2
Locomotion velocity, session 7	292.79	1	1	33.3	1e+00	Retreg2
Locomotion distance, session 7	435.3	2	1	33.3	1e+00	Ndufb9 Retreg2
Stereotopy head waving bouts, day 7	1279.33	2	2	66.7	1e+00	Ndufb9 Retreg2
Stereotopy head waving duration, day 7	1081.37	2	2	66.7	1e+00	Ndufb9 Retreg2
Locomotion velocity, session 8	409.23	1	1	33.3	1e+00	Retreg2
Locomotion distance, session 8	147.88	1	1	33.3	1e+00	Retreg2
Degree of sensitization distance	3670.85	1	1	33.3	1e+00	Retreg2
Degree of sensitization stereotypy	1029.63	2	1	33.3	1e+00	Ndufb9 Retreg2
Condit. Reinf. active minus inactive responses	957.65	1	1	33.3	1e+00	Retreg2
Condit. Reinf. active-inactive response ratio	242.03	1	1	33.3	1e+00	Retreg2
Condit. Reinf. active responses	2765.7	1	1	33.3	1e+00	Retreg2
Condit. Reinf. inactive responses	2347.53	2	1	33.3	1e+00	Ndufb9 Retreg2
Incentive salience index mean	3540.72	1	1	33.3	1e+00	Retreg2
Condit. Reinf. lever presses	5282.33	1	1	33.3	1e+00	Retreg2
Time in familiar zone, hab. session 1	11168.49	1	1	33.3	1e+00	Retreg2
Time in novel zone, hab. session 1	9232.79	1	1	33.3	1e+00	Retreg2
Total zone transitions, hab. session 1	221.7	2	1	33.3	1e+00	Ndufb9 Retreg2
Total locomotion distance, hab. session 1	394.1	1	1	33.3	1e+00	Retreg2
Locomotion velocity, hab. session 1	266.96	1	1	33.3	1e+00	Retreg2
Time in familiar zone, hab. session 2	5880.03	1	1	33.3	1e+00	Retreg2
Time in novel zone, hab. session 2	6311.49	1	1	33.3	1e+00	Retreg2
Total zone transitions, hab. session 2	35.66	2	1	33.3	1e+00	Ndufb9 Retreg2
Total locomotion distance, hab. session 2	22.17	1	1	33.3	1e+00	Retreg2
Locomotion velocity, hab. session 2	31.27	1	1	33.3	1e+00	Retreg2
Novel to familiar place preference ratio	7672.78	2	1	33.3	1e+00	Ccny Retreg2
Novelty place preference	14927.56	1	1	33.3	1e+00	Retreg2
Time in novel zone, NPP test	10685.62	1	1	33.3	1e+00	Retreg2
Total zone transitions, NPP test	980.79	2	2	66.7	1e+00	Ndufb9 Retreg2
Total locomotion distance, NPP test	1687.31	1	1	33.3	1e+00	Retreg2
Locomotion velocity, NPP test	479.14	2	1	33.3	1e+00	Ccny Retreg2
Pavlov. Cond. lever latency	248.61	2	1	33.3	1e+00	Ndufb9 Retreg2
Pavlov. Cond. change in total contacts	1037.76	1	1	33.3	1e+00	Retreg2
Pavlov. Cond. index score	384.43	1	1	33.3	1e+00	Retreg2
Pavlov. Cond. latency score	404.63	1	1	33.3	1e+00	Retreg2
Pavlov. Cond. lever contacts	344.19	2	1	33.3	1e+00	Ndufb9 Retreg2
Pavlov. Cond. magazine entry number	491.61	1	1	33.3	1e+00	Retreg2
Pavlov. Cond. intertrial magazine entries	69.21	2	1	33.3	1e+00	Ndufb9 Retreg2
Pavlov. Cond. lever-magazine prob. diff.	418.89	1	1	33.3	1e+00	Retreg2
Pavlov. Cond. response bias	583.93	1	1	33.3	1e+00	Retreg2
Bone: apparent density	2735.95	2	1	33.3	1e+00	Ndufb9 Retreg2
Bone surface	6197.68	1	1	33.3	1e+00	Retreg2
Bone volume	8624.75	1	1	33.3	1e+00	Retreg2
Bone: connectivity density	841.82	2	1	33.3	1e+00	Ndufb9 Retreg2
Bone: cortical apparent density	6014.36	2	1	33.3	1e+00	Ndufb9 Retreg2
Bone: cortical area	2293.91	2	1	33.3	1e+00	Ndufb9 Retreg2
Bone: cortical porosity	221.79	2	1	33.3	1e+00	Ndufb9 Retreg2
Bone: cortical porosity	560.57	2	1	33.3	1e+00	Ndufb9 Retreg2
Bone: cortical thickness	191.17	2	1	33.3	1e+00	Ndufb9 Retreg2
Bone: cortical thickness	1464.97	2	1	33.3	1e+00	Ndufb9 Retreg2
Bone: cortical tissue density	6505.97	2	1	33.3	1e+00	Ndufb9 Retreg2
Bone: elastic displacement	7604.03	1	1	33.3	1e+00	Retreg2
Bone: elastic work	361.86	1	1	33.3	1e+00	Retreg2
Bone: endosteal estimation	4460.13	2	1	33.3	1e+00	Ndufb9 Retreg2
Bone: endosteal perimeter	11863.6	1	1	33.3	1e+00	Retreg2
Bone: final force	1600.36	1	1	33.3	1e+00	Retreg2
Bone: final moment	219.15	1	1	33.3	1e+00	Retreg2
Bone: marrow area	4718.77	2	1	33.3	1e+00	Ndufb9 Retreg2
Bone: maximum diameter	3037.24	2	1	33.3	1e+00	Ndufb9 Retreg2
Bone: maximum force	8697.09	1	1	33.3	1e+00	Retreg2
Bone: maximum moment	2996.54	2	1	33.3	1e+00	Ndufb9 Retreg2
Bone: minimum diameter	4100.86	1	1	33.3	1e+00	Retreg2
Bone: periosteal estimation	9791.57	1	1	33.3	1e+00	Retreg2
Bone: periosteal perimeter	11400.25	1	1	33.3	1e+00	Retreg2
Bone: post-yield work	13672.98	1	1	33.3	1e+00	Retreg2
Bone: stiffness	9032.86	1	1	33.3	1e+00	Retreg2
Bone: tissue strength	2995.95	1	1	33.3	1e+00	Retreg2
Bone: trabecular number	5387.39	2	2	66.7	1e+00	Ndufb9 Retreg2
Bone: trabecular spacing	3988.39	2	2	66.7	1e+00	Ndufb9 Retreg2
Bone: trabecular thickness	8476.26	1	1	33.3	1e+00	Retreg2
Bone: trabecular tissue density	7288.68	2	2	66.7	1e+00	Ndufb9 Retreg2
Breakpoint value in progressive ratio session	37605.61	1	1	33.3	1e+00	Retreg2
Distance traveled before self-admin	16852.04	3	1	33.3	1e+00	Ccny Ndufb9 Retreg2
Distance traveled after self-admin	10833.08	3	2	66.7	1e+00	Ccny Ndufb9 Retreg2
Delta time in closed arm before/after self-admin	128.82	3	2	66.7	1e+00	Ccny Ndufb9 Retreg2
Delta time in open arm before/after self-admin	7570.09	2	1	33.3	1e+00	Ccny Retreg2
Diff in mean of infusions in LGA sessions	18328.29	2	1	33.3	1e+00	Ndufb9 Retreg2
Extinction: sum of active levers before priming	9485.81	3	3	100	1e+00	Ccny Ndufb9 Retreg2
Active lever presses in extinction session 6	393.1	2	2	66.7	1e+00	Ccny Retreg2
Delta distance traveled before/after self-admin	996.98	3	2	66.7	1e+00	Ccny Ndufb9 Retreg2
Delta ambulatory time before/after self-admin	10288.96	3	1	33.3	1e+00	Ccny Ndufb9 Retreg2
Time in closed arm before self-admin	13436.63	2	1	33.3	1e+00	Ccny Retreg2
Time in closed arm after self-admin	2325.44	2	2	66.7	1e+00	Ccny Retreg2
Time in open arm before self-admin	2947.63	3	3	100	1e+00	Ccny Ndufb9 Retreg2
Time in open arm after self-admin	177.04	3	2	66.7	1e+00	Ccny Ndufb9 Retreg2
Sum of active levers in priming session hrs 5-6	496.26	2	1	33.3	1e+00	Ndufb9 Retreg2
Time to tail flick, vehicle, before self-admin	4492.14	3	2	66.7	1e+00	Ccny Ndufb9 Retreg2
Time to tail flick, vehicle, after self-admin	14057.72	3	1	33.3	1e+00	Ccny Ndufb9 Retreg2
Time to tail flick, test, before self-admin	4093.6	2	2	66.7	1e+00	Ndufb9 Retreg2
Time to tail flick, test, after self-admin	501.19	3	2	66.7	1e+00	Ccny Ndufb9 Retreg2
Delta time to tail flick, vehicle, before/after SA	4937.06	2	2	66.7	1e+00	Ccny Retreg2
Delta time to tail flick, test, before/after SA	7848.65	2	1	33.3	1e+00	Ndufb9 Retreg2
Ambulatory time before self-admin	39445.74	2	1	33.3	1e+00	Ccny Retreg2
Ambulatory time after self-admin	13316.09	2	1	33.3	1e+00	Ccny Retreg2
Total heroin consumption	134.58	2	2	66.7	1e+00	Ccny Retreg2
Area under the delay curve	24791.27	1	1	33.3	1e+00	Retreg2
Delay disc. indifference point, 0s delay	2159.25	1	1	33.3	1e+00	Retreg2
Delay disc. indifference point, 16s delay	10986.22	2	1	33.3	1e+00	Ccny Retreg2
Delay disc. indifference point, 2s delay	155.27	1	1	33.3	1e+00	Retreg2
Delay disc. indifference point, 24s delay	16227.16	2	1	33.3	1e+00	Ccny Retreg2
Delay disc. indifference point, 4s delay	214.83	3	1	33.3	1e+00	Ccny Ndufb9 Retreg2
Delay disc. indifference point, 8s delay	33362.4	1	1	33.3	1e+00	Retreg2
Delay discount exponential model param	16922.54	1	1	33.3	1e+00	Retreg2
Delay discount hyperbolic model param	12277.65	1	1	33.3	1e+00	Retreg2
Fecal boli incidents, locomotor time 1	61202.36	1	1	33.3	1e+00	Retreg2
Change in fecal boli incidents, locomotor task	1914.03	3	3	100	1e+00	Ccny Ndufb9 Retreg2
Time >=10cm from walls, locomotor time 1	4342.59	3	1	33.3	1e+00	Ccny Ndufb9 Retreg2
Bouts of movement, locomotor time 1	3607.99	3	2	66.7	1e+00	Ccny Ndufb9 Retreg2
Total resting periods, locomotor time 1	1407.78	2	1	33.3	1e+00	Ccny Retreg2
Rest time, locomotor task time 1	11183.83	2	1	33.3	1e+00	Ndufb9 Retreg2
Distance moved, locomotor task time 1	22964.53	3	2	66.7	1e+00	Ccny Ndufb9 Retreg2
Vertical activity count, locomotor time 1	142354.07	1	1	33.3	1e+00	Retreg2
Time >=10cm from walls, locomotor time 2	35582.77	2	1	33.3	1e+00	Ccny Retreg2
Bouts of movement, locomotor time 2	41025.7	2	2	66.7	1e+00	Ccny Retreg2
Total resting periods, locomotor time 2	49531.53	2	2	66.7	1e+00	Ccny Retreg2
Rest time, locomotor task time 2	12756.26	2	1	33.3	1e+00	Ndufb9 Retreg2
Distance moved, locomotor task time 2	2835.6	3	2	66.7	1e+00	Ccny Ndufb9 Retreg2
Vertical activity count, locomotor time 2	26786.04	2	1	33.3	1e+00	Ccny Retreg2
Weight adjusted by age	23619.48	3	3	100	1e+00	Ccny Ndufb9 Retreg2
Seeking ratio, delayed vs. immediate footshock	6729.38	2	1	33.3	1e+00	Ccny Retreg2
Locomotion in novel chamber	1330.8	3	2	66.7	1e+00	Ccny Ndufb9 Retreg2
Locomotion in novel chamber post-restriction	21811.49	3	1	33.3	1e+00	Ccny Ndufb9 Retreg2
Food seeking constrained by brief footshock	941.83	2	1	33.3	1e+00	Ndufb9 Retreg2
Seeking ratio, punishment vs. effort	13770.59	3	2	66.7	1e+00	Ccny Ndufb9 Retreg2
Run reversals in cocaine runway, females	9406.04	1	1	33.3	1e+00	Retreg2
Run reversals in cocaine runway, males	3884.61	2	2	66.7	1e+00	Ndufb9 Retreg2
Latency to leave start box in cocaine runway	8153.9	2	1	33.3	1e+00	Ccny Retreg2
Latency to leave start box in cocaine runway, F	3596.44	2	2	66.7	1e+00	Ndufb9 Retreg2
Latency to leave start box in cocaine runway, M	593.09	3	2	66.7	1e+00	Ccny Ndufb9 Retreg2
Cd content in liver	5.39	1	0	0	1e+00	Ndufb9
Co content in liver	1133.25	1	1	33.3	1e+00	Retreg2
Cu content in liver	28.08	2	1	33.3	1e+00	Ndufb9 Retreg2
Fe content in liver	1344.53	1	1	33.3	1e+00	Retreg2
K content in liver	1519.62	1	1	33.3	1e+00	Retreg2
Mg content in liver	6026.97	1	1	33.3	1e+00	Retreg2
Mn content in liver	537.3	2	2	66.7	1e+00	Ndufb9 Retreg2
Na content in liver	2013.84	2	1	33.3	1e+00	Ndufb9 Retreg2
Rb content in liver	71.08	2	2	66.7	1e+00	Ndufb9 Retreg2
Se content in liver	8.63	1	0	0	1e+00	Ndufb9
Zn content in liver	1887.46	2	2	66.7	1e+00	Ndufb9 Retreg2

Associations by panel

Tissue	RNA modality	# hits	Avg chisq
Adipose	alternative polyA	0	1.1
Adipose	alternative TSS	0	1.13
Adipose	gene expression	0	1.1
Adipose	isoform ratio	0	1.14
Adipose	intron excision ratio	0	1.15
Adipose	mRNA stability	1	1.14
BLA	alternative polyA	0	1.15
BLA	alternative TSS	0	1.12
BLA	gene expression	0	1.14
BLA	isoform ratio	0	1.14
BLA	intron excision ratio	0	1.19
BLA	mRNA stability	0	1.08
Brain	alternative polyA	0	1.1
Brain	alternative TSS	0	1.14
Brain	gene expression	0	1.11
Brain	isoform ratio	0	1.11
Brain	intron excision ratio	0	1.12
Brain	mRNA stability	0	1.08
Eye	alternative polyA	0	1.22
Eye	alternative TSS	0	1.11
Eye	gene expression	0	1.22
Eye	isoform ratio	0	1.06
Eye	intron excision ratio	0	1.43
Eye	mRNA stability	0	1.13
IC	alternative polyA	0	1.19
IC	alternative TSS	0	1.15
IC	gene expression	0	1.18
IC	isoform ratio	0	1.19
IC	intron excision ratio	0	1.24
IC	mRNA stability	0	1.12
IL	alternative polyA	0	1.19
IL	alternative TSS	0	1.33
IL	gene expression	0	1.19
IL	isoform ratio	0	1.11
IL	intron excision ratio	0	1.34
IL	mRNA stability	0	1.07
LHb	alternative polyA	0	1.25
LHb	alternative TSS	0	1.17
LHb	gene expression	0	1.23
LHb	isoform ratio	0	1.31
LHb	intron excision ratio	0	1.52
LHb	mRNA stability	0	1.11
Liver	alternative polyA	0	1.1
Liver	alternative TSS	0	1.21
Liver	gene expression	0	1.13
Liver	isoform ratio	0	1.15
Liver	intron excision ratio	0	1.14
Liver	mRNA stability	0	1.09
NAcc	alternative polyA	1	31.3
NAcc	alternative TSS	0	1.18
NAcc	gene expression	0	1.12
NAcc	isoform ratio	0	1.13
NAcc	intron excision ratio	0	1.22
NAcc	mRNA stability	0	1.06
OFC	alternative polyA	0	1.12
OFC	alternative TSS	0	1.18
OFC	gene expression	0	1.22
OFC	isoform ratio	0	1.18
OFC	intron excision ratio	0	1.57
OFC	mRNA stability	0	1.08
PL	alternative polyA	0	1.15
PL	alternative TSS	0	1.14
PL	gene expression	0	1.15
PL	isoform ratio	0	1.1
PL	intron excision ratio	0	1.23
PL	mRNA stability	0	1.06
pVTA	alternative polyA	0	1.12
pVTA	alternative TSS	0	1.1
pVTA	gene expression	1	1.15
pVTA	isoform ratio	0	1.17
pVTA	intron excision ratio	0	1.32
pVTA	mRNA stability	0	1.07
RMTg	alternative polyA	0	1.34
RMTg	alternative TSS	0	1.23
RMTg	gene expression	0	1.24
RMTg	isoform ratio	0	1.27
RMTg	intron excision ratio	0	1.43
RMTg	mRNA stability	0	1.05