Hub : Genes

Pak1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Liver intron excision ratio chr1_152151695_152173951 0.04 0.03 1.4e-03 0.02 0.02 0.02 0.01 3.0e-03 4.3e-03 4.0e-03 9.9e-03
2 Liver gene expression Pak1 0.1 0.06 5.0e-09 0.05 0.06 0.06 0.06 1.4e-06 1.1e-07 4.1e-07 4.0e-07
3 Adipose gene expression Pak1 0.03 0.03 5.6e-03 0 -0 -0 0.02 1.1e-01 4.1e-01 4.4e-01 5.9e-03
4 Brain mRNA stability Pak1 0.05 0.03 8.9e-04 0.03 0.03 0.02 0.02 5.8e-04 7.7e-04 2.7e-03 2.2e-03
5 LHb intron excision ratio chr1_152160825_152173954 0.21 0.13 7.3e-03 0.02 0.01 0 0.01 1.2e-01 2.2e-01 3.1e-01 2.1e-01
6 Brain isoform ratio NM_017198.2 0.07 0.05 3.0e-03 0.03 0.03 0.01 0.01 1.8e-03 1.4e-03 1.8e-02 1.4e-02
7 Brain gene expression Pak1 0.19 0.09 0.0e+00 0.14 0.18 0.16 0.17 1.0e-12 3.2e-16 7.6e-15 1.5e-15
8 NAcc gene expression Pak1 0.07 0.05 1.4e-07 0.05 0.04 0.04 0.04 1.2e-06 2.7e-05 4.7e-05 1.5e-05
9 PL gene expression Pak1 0.84 0 0.0e+00 0.2 0.16 0.19 0.17 3.7e-21 1.7e-17 4.4e-20 3.4e-18
10 IL gene expression Pak1 0.53 0.15 7.4e-10 0.23 0.28 0.26 0.27 3.5e-06 1.8e-07 5.0e-07 3.1e-07
11 BLA gene expression Pak1 0.11 0.07 1.6e-04 0.05 0.05 0.04 0.04 7.2e-04 1.5e-03 4.0e-03 4.0e-03
12 OFC gene expression Pak1 0.37 0.15 2.5e-07 0.27 0.26 0.26 0.25 3.4e-07 7.2e-07 9.3e-07 9.7e-07
13 pVTA gene expression Pak1 0.25 0.14 1.3e-05 0.04 0.09 0.09 0.05 1.2e-02 1.5e-04 7.5e-05 3.5e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13
Bone: apparent density0.20.30.70.5-0.3-0.4-0.2-0.4-0.00.5-0.5-0.50.5-0.8-0.8-0.6
Area under the delay curve0.40.41.3-0.00.8-1.1-1.10.8-1.1-0.2-0.3-0.30.2-0.1-0.2-0.6
BMI with tail0.61.84.30.4-0.52.12.0-0.31.0-1.21.71.7-1.71.41.30.4
BMI without tail4.08.318.0-0.4-0.74.24.2-0.92.2-2.33.53.5-3.33.23.22.1
Body weight1.66.913.8-0.4-0.23.73.6-0.21.5-2.63.53.5-3.32.82.81.3
Weight adjusted by age1.41.63.3-1.01.00.50.71.0-0.6-1.81.71.7-1.81.51.40.7
Bone surface0.71.33.2-1.41.8-1.4-1.21.8-1.7-1.20.50.5-0.70.30.1-0.0
Bone volume0.50.81.9-1.01.4-0.8-0.61.4-1.4-1.10.70.7-0.80.40.3-0.1
Breakpoint value in progressive ratio session0.40.42.00.7-0.0-0.6-0.90.4-0.50.3-0.6-0.60.5-0.6-0.6-1.4
Number of licking bursts1.21.55.02.2-2.01.61.5-1.41.40.8-0.2-0.20.3-0.2-0.3-0.6
Context. condit. distance diff. score1.82.15.2-1.01.9-2.3-2.22.1-2.2-0.7-0.3-0.30.1-0.6-0.4-1.5
Locomotion velocity, session 10.80.92.00.10.3-1.3-1.40.3-0.70.7-1.2-1.21.0-1.0-0.9-0.9
Locomotion distance, session 10.20.30.9-0.50.6-0.9-0.90.6-0.50.1-0.5-0.50.4-0.1-0.10.2
Locomotion velocity, session 20.40.40.9-0.81.0-0.7-0.91.0-0.9-0.50.20.2-0.30.20.20.5
Locomotion distance, session 20.10.10.9-0.70.20.10.10.00.3-0.10.10.1-0.00.20.30.9
Locomotion velocity, session 30.10.20.4-0.50.6-0.7-0.70.6-0.6-0.1-0.2-0.20.1-0.1-0.2-0.1
Locomotion distance, session 31.21.33.6-0.71.3-1.9-1.91.5-1.6-0.1-0.7-0.70.4-0.5-0.6-1.0
Stereotopy head waving bouts, day 31.61.95.70.6-1.72.12.0-2.02.40.80.20.20.1-0.0-0.21.3
Stereotopy head waving duration, day 30.20.30.8-0.2-0.40.30.2-0.70.90.6-0.4-0.40.5-0.4-0.60.6
Locomotion velocity, session 70.40.42.20.40.3-0.8-0.80.6-1.0-0.1-0.2-0.20.1-0.5-0.3-1.5
Locomotion distance, session 70.70.92.7-0.11.0-0.9-0.71.5-1.6-1.00.60.6-0.80.40.5-1.3
Stereotopy head waving bouts, day 70.30.40.8-0.90.2-0.4-0.5-0.00.40.5-0.7-0.70.7-0.9-0.80.4
Stereotopy head waving duration, day 70.30.32.1-1.50.8-0.5-0.60.60.0-0.1-0.1-0.10.1-0.3-0.20.8
Locomotion velocity, session 83.74.411.9-1.22.5-3.4-3.32.6-3.3-0.8-0.6-0.60.2-1.2-1.0-2.5
Locomotion distance, session 80.81.22.8-1.31.6-1.6-1.61.7-1.5-0.6-0.1-0.1-0.0-0.4-0.2-0.5
Degree of sensitization distance1.51.52.9-0.0-0.11.31.50.10.3-1.21.71.7-1.51.51.60.7
Degree of sensitization stereotypy1.21.33.3-1.71.4-1.8-1.81.3-0.90.1-0.8-0.80.7-1.0-0.9-0.1
Conditioned locomotion0.20.20.50.3-0.2-0.4-0.3-0.0-0.00.6-0.7-0.70.7-0.5-0.5-0.5
Cocaine response after cond. corrected0.20.30.70.80.20.0-0.30.5-0.8-0.50.40.4-0.50.70.6-0.5
Cocaine response after cond. not corrected0.10.10.40.50.1-0.3-0.60.2-0.5-0.1-0.1-0.10.00.00.0-0.3
Cocaine response before conditioning0.81.01.8-0.4-0.5-0.3-0.1-0.91.21.2-1.1-1.11.3-1.3-1.20.9
Saline control response0.91.23.1-1.81.20.10.20.8-0.2-1.31.21.2-1.21.21.40.9
Bone: connectivity density0.60.92.00.20.3-1.4-1.20.2-0.70.6-1.1-1.11.0-1.2-1.3-0.9
Bone: cortical apparent density0.10.20.80.9-0.70.60.4-0.40.30.20.10.1-0.10.10.2-0.3
Bone: cortical area0.81.22.7-0.91.1-0.10.31.3-0.9-1.61.41.4-1.51.01.10.2
Bone: cortical porosity0.30.30.6-0.6-0.1-0.2-0.3-0.20.60.7-0.7-0.70.8-0.6-0.50.7
Bone: cortical porosity0.30.30.6-0.5-0.2-0.0-0.1-0.30.80.8-0.7-0.70.8-0.6-0.50.8
Bone: cortical thickness0.10.10.40.6-0.30.30.50.20.0-0.30.40.4-0.30.10.2-0.4
Bone: cortical thickness0.60.72.0-0.21.0-1.1-1.01.4-1.4-0.70.10.1-0.40.40.5-0.9
Bone: cortical tissue density0.10.20.80.9-0.70.60.4-0.40.40.3-0.0-0.0-0.00.00.1-0.3
Condit. Reinf. active minus inactive responses1.21.33.1-0.30.31.01.00.30.0-1.31.51.5-1.51.81.70.8
Condit. Reinf. active-inactive response ratio1.21.22.7-0.50.31.01.00.40.2-1.11.51.5-1.31.61.61.1
Condit. Reinf. active responses0.60.71.70.0-0.21.01.0-0.10.3-0.71.11.1-1.01.31.20.6
Condit. Reinf. inactive responses0.00.00.10.2-0.20.10.2-0.10.10.00.00.0-0.00.1-0.1-0.2
Incentive salience index mean0.81.02.4-0.40.60.50.50.6-0.6-1.31.31.3-1.31.61.50.4
Condit. Reinf. lever presses0.30.41.4-0.30.8-0.7-0.70.7-1.2-0.60.30.3-0.40.40.3-0.7
Condit. Reinf. active minus inactive responses4.05.010.6-3.32.9-0.9-0.82.7-1.8-2.82.12.1-2.22.12.11.6
Condit. Reinf. active-inactive response ratio1.71.83.7-1.31.8-1.1-1.21.9-1.8-1.61.01.0-1.21.11.10.1
Condit. Reinf. active responses5.67.717.0-4.13.5-0.6-0.53.1-1.8-3.52.82.8-2.92.82.82.5
Condit. Reinf. inactive responses3.13.89.5-3.11.70.80.91.30.1-2.12.12.1-2.02.02.12.9
Condit. Reinf. lever presses6.68.928.1-5.34.7-2.8-2.84.2-2.8-3.01.51.5-1.71.61.51.8
Condit. Reinf. lever reinforcers received5.67.918.4-4.33.7-0.9-0.73.2-2.0-3.52.72.7-2.82.72.72.4
Conditioned reinforcement - actives1.51.54.4-1.01.5-2.1-2.01.4-1.5-0.1-0.6-0.60.5-0.9-0.9-1.1
Conditioned reinforcement - inactives0.10.10.40.4-0.20.0-0.20.1-0.00.3-0.2-0.20.3-0.6-0.6-0.3
Conditioned locomotion1.31.64.4-1.01.4-2.1-2.01.2-1.40.0-0.8-0.80.7-1.3-1.3-1.1
Patch foraging indifference point 0 sec1.32.17.6-2.82.1-0.8-0.81.8-0.7-1.51.01.0-0.91.01.11.7
Patch foraging indifference point AUC0.20.20.5-0.10.40.00.10.4-0.4-0.60.60.6-0.60.70.5-0.1
Delay disc. indifference point, 0s delay0.40.41.0-0.90.8-0.1-0.10.7-0.4-0.80.70.7-0.71.00.60.5
Delay disc. indifference point, 16s delay0.60.61.50.10.3-1.2-1.20.4-0.80.5-1.0-1.00.8-0.8-0.4-0.9
Delay disc. indifference point, 2s delay0.50.51.4-1.21.1-0.8-0.81.0-0.8-0.60.20.2-0.20.2-0.20.6
Delay disc. indifference point, 24s delay0.40.41.70.9-0.2-0.5-0.50.0-0.50.4-0.5-0.50.4-0.5-0.4-1.3
Delay disc. indifference point, 4s delay1.11.12.4-1.11.5-0.6-0.61.5-1.3-1.41.01.0-1.10.70.6-0.0
Delay disc. indifference point, 8s delay0.60.61.8-0.10.9-1.3-1.30.9-1.3-0.1-0.3-0.30.2-0.2-0.1-0.9
Indifference point function ln k0.40.61.4-0.70.5-1.0-1.10.2-0.10.5-0.8-0.80.8-1.2-0.8-0.3
Indifference point function log k0.40.61.4-0.70.5-1.0-1.10.2-0.10.5-0.8-0.80.8-1.2-0.8-0.3
Patch foraging total patch changes 0 sec1.01.75.7-2.41.9-0.9-0.91.7-0.8-1.30.80.8-0.80.81.01.3
Patch foraging total patch changes 12 sec0.91.12.1-1.21.10.10.31.0-0.5-1.51.41.4-1.31.21.10.3
Patch foraging total patch changes 18 sec1.41.83.1-1.81.6-0.2-0.21.5-1.0-1.61.41.4-1.41.41.51.1
Patch foraging total patch changes 24 sec0.91.12.6-1.01.00.20.10.9-0.5-1.31.21.2-1.21.61.41.0
Patch foraging total patch changes 6 sec0.10.10.4-0.60.4-0.4-0.30.30.1-0.10.00.00.10.1-0.00.5
Patch foraging time to switch 0 sec1.72.66.72.4-2.61.51.3-2.11.81.9-0.9-0.91.2-1.1-1.2-0.9
Patch foraging water rate 0 sec1.11.85.2-2.02.3-1.5-1.41.9-1.5-1.40.40.4-0.70.80.70.4
Patch foraging water rate 12 sec0.61.02.9-1.51.7-1.4-1.31.3-1.2-0.70.00.0-0.10.20.2-0.1
Patch foraging water rate 18 sec0.60.81.9-0.91.4-0.5-0.71.4-1.2-1.00.60.6-0.70.91.00.2
Patch foraging water rate 24 sec0.81.03.2-0.61.1-1.6-1.81.0-1.30.2-0.8-0.80.7-0.8-0.7-0.8
Patch foraging water rate 6 sec0.40.51.7-0.50.8-1.3-1.20.4-0.80.2-0.8-0.80.6-0.4-0.4-0.2
Seeking ratio, delayed vs. immediate footshock0.30.32.01.4-0.5-0.0-0.1-0.2-0.50.3-0.2-0.20.2-0.2-0.1-1.0
Distance traveled before self-admin0.10.10.40.3-0.40.40.2-0.20.10.20.00.00.00.10.10.7
Distance traveled after self-admin1.11.22.31.1-1.50.50.3-1.31.21.5-1.1-1.11.3-1.0-1.00.4
Extensor digitorum longus weight0.31.22.7-0.20.60.70.61.1-0.6-1.51.51.5-1.61.21.3-0.4
Bone: elastic displacement0.60.72.21.5-0.8-0.2-0.2-0.40.00.9-0.9-0.90.8-0.7-0.8-1.2
Bone: elastic work1.52.03.31.8-0.9-1.0-1.1-0.4-0.21.5-1.7-1.71.6-1.6-1.6-1.8
Bone: endosteal estimation1.12.54.6-1.91.8-0.10.21.4-1.3-2.21.91.9-2.01.71.60.8
Bone: endosteal perimeter1.63.26.7-2.52.6-0.9-0.72.1-2.0-2.31.81.8-1.91.41.40.7
Epididymis fat weight1.84.29.50.2-0.53.12.8-0.31.0-1.82.82.8-2.62.31.91.4
Delta time in closed arm before/after self-admin1.01.02.5-0.00.50.20.40.7-0.9-1.21.21.2-1.31.41.6-0.2
Delta time in open arm before/after self-admin0.80.82.4-1.61.4-0.2-0.51.2-0.7-1.10.80.8-0.80.70.70.5
Diff in mean of infusions in LGA sessions1.21.43.61.9-1.91.41.3-1.61.30.9-0.3-0.30.4-0.5-0.7-1.1
Delay discount exponential model param0.40.41.3-0.0-0.71.11.1-0.81.10.10.30.3-0.20.20.20.6
Extinction: sum of active levers before priming0.30.30.6-0.20.50.1-0.10.8-0.6-0.80.70.7-0.70.70.70.0
Active lever presses in extinction session 60.60.61.5-1.10.6-0.6-1.10.40.20.5-0.8-0.80.9-0.3-0.51.2
Bone: final force0.20.31.00.10.4-0.9-0.70.6-0.7-0.2-0.2-0.20.1-0.6-0.5-1.0
Bone: final moment0.20.30.7-0.10.5-0.8-0.60.6-0.7-0.3-0.0-0.0-0.0-0.5-0.4-0.8
Food consumed during 24 hour testing period0.91.03.8-1.91.3-1.4-1.40.9-0.70.1-0.5-0.50.5-1.0-0.90.4
Glucose0.30.51.2-0.30.9-0.9-0.81.1-1.1-0.50.20.2-0.2-0.5-0.5-0.7
Heart weight0.50.81.6-0.91.3-0.9-0.91.3-1.2-0.80.30.3-0.40.90.70.6
Delay discount hyperbolic model param0.50.51.40.3-1.01.11.1-1.01.20.40.10.10.0-0.00.00.4
Intermittent access intake day 1-15 change1.11.03.0-1.31.3-1.7-1.71.1-1.2-0.1-0.5-0.50.5-0.6-0.60.2
Intermittent access intake escalation1.21.23.3-1.51.6-1.8-1.81.3-1.3-0.2-0.4-0.40.3-0.5-0.50.4
Intermittent access intake escalation 20.30.30.6-0.80.8-0.5-0.50.7-0.5-0.40.30.3-0.20.1-0.10.7
Intermitt. access day 1 inactive lever presses0.30.40.90.4-0.80.80.7-0.80.70.5-0.0-0.00.2-0.3-0.30.9
Intermitt. access day 15 inactive lever presses0.10.10.3-0.1-0.1-0.1-0.5-0.0-0.00.3-0.2-0.20.3-0.5-0.40.5
Intermitt. access escalation Index0.20.20.6-0.2-0.40.20.3-0.60.60.5-0.4-0.40.4-0.6-0.80.0
Intermittent access day 1 total infusions0.70.81.9-1.01.3-0.9-0.91.4-1.3-1.00.60.6-0.60.30.2-0.1
Intermittent access day 15 total infusions1.71.94.8-1.72.0-2.2-2.21.9-2.0-0.6-0.1-0.10.1-0.5-0.7-0.0
Intermittent access terminal intake (last 3 days)0.91.02.5-1.31.6-1.3-1.41.6-1.5-0.70.30.3-0.3-0.2-0.40.2
Intermittent access total infusions0.70.82.1-1.01.3-1.0-1.11.4-1.3-0.80.40.4-0.4-0.2-0.3-0.2
Intermittent access day 1 locomotion0.40.41.30.00.3-0.9-0.80.2-0.60.2-0.5-0.50.4-0.9-1.1-1.0
Intermittent access day 15 total locomotion0.70.82.2-1.51.4-1.2-1.21.2-1.1-0.60.20.2-0.2-0.2-0.20.4
Intermittent access total locomotion0.40.41.1-1.01.0-0.7-0.60.8-0.8-0.70.40.4-0.4-0.3-0.3-0.2
Intermittent access standard deviation0.10.10.1-0.40.30.2-0.00.4-0.1-0.30.30.3-0.40.1-0.00.4
Left kidney weight1.43.96.5-2.01.31.41.51.2-0.0-2.42.52.5-2.52.32.42.0
Right kidney weight1.02.85.3-1.60.71.61.50.50.5-1.72.02.0-2.02.12.12.3
Cocaine induced anxiety0.80.92.81.7-1.60.81.1-1.51.00.9-0.3-0.30.5-0.6-0.4-0.4
Post-drug Anxiety0.10.10.70.9-0.50.30.3-0.20.10.30.00.00.10.10.30.3
Baseline Anxiety1.31.43.4-1.71.8-1.3-1.51.8-1.5-0.90.30.3-0.40.70.70.7
Tail length3.510.517.4-2.71.23.23.30.60.9-3.54.24.2-4.03.83.93.4
Length with tail1.86.411.7-1.40.43.13.20.11.2-2.63.43.4-3.22.82.82.1
Length without tail0.10.30.80.9-0.50.0-0.1-0.30.20.5-0.4-0.40.5-0.6-0.7-0.8
Times rat made contact with spout0.50.62.00.2-0.71.31.4-1.01.0-0.00.60.6-0.50.10.10.6
Lifetime Intake0.80.92.2-1.11.4-1.2-1.21.5-1.4-0.70.30.3-0.3-0.1-0.1-0.1
Liver weight, left0.50.82.30.3-0.31.21.5-0.40.6-0.81.31.3-1.10.60.50.3
Liver weight, right2.44.012.51.1-1.73.33.5-1.72.3-0.82.12.1-1.71.20.91.3
Locomotor activity0.71.04.4-1.0-0.21.01.4-0.81.4-0.00.50.5-0.30.81.12.1
Locomotor testing distance1.42.35.3-1.91.10.71.00.50.3-1.51.61.6-1.52.02.32.1
Locomotor testing rearing2.03.15.9-0.80.31.92.10.00.9-1.72.32.3-2.02.22.41.5
Locomotion in novel chamber0.91.24.0-0.90.8-2.0-1.20.3-0.60.2-0.8-0.80.8-1.5-1.7-0.7
Locomotion in novel chamber post-restriction2.12.58.3-1.41.8-2.9-2.61.5-1.7-0.0-1.0-1.00.9-1.3-1.5-0.7
Fecal boli incidents, locomotor time 11.21.33.9-1.01.5-1.9-2.01.4-1.8-0.4-0.5-0.50.20.30.3-0.1
Change in fecal boli incidents, locomotor task1.21.12.61.3-1.61.11.1-1.61.51.1-0.5-0.50.7-0.9-0.6-0.0
Time >=10cm from walls, locomotor time 10.80.82.4-1.00.9-1.4-1.50.8-0.60.2-0.9-0.90.7-0.7-0.7-0.6
Bouts of movement, locomotor time 10.30.30.8-0.40.8-0.7-0.90.9-0.8-0.40.10.1-0.20.10.10.3
Total resting periods, locomotor time 10.30.41.40.00.5-1.0-1.20.6-0.80.1-0.3-0.30.4-0.6-0.5-0.2
Rest time, locomotor task time 10.50.61.60.50.3-1.2-1.30.3-0.80.5-0.7-0.70.8-0.8-0.6-0.7
Distance moved, locomotor task time 11.31.42.5-1.10.60.90.90.7-0.1-1.41.51.5-1.61.61.40.8
Vertical activity count, locomotor time 10.80.81.8-1.00.60.60.60.6-0.1-1.01.01.0-1.11.31.01.1
Time >=10cm from walls, locomotor time 20.60.71.6-1.31.2-0.5-0.61.0-0.9-1.00.50.5-0.70.90.60.3
Bouts of movement, locomotor time 20.40.42.5-1.00.50.20.20.40.1-0.50.70.7-0.50.30.31.6
Total resting periods, locomotor time 20.20.21.8-0.70.40.20.10.30.1-0.30.40.4-0.30.20.21.3
Rest time, locomotor task time 21.41.63.71.9-1.70.50.5-1.51.11.4-1.2-1.21.2-1.3-0.9-1.3
Distance moved, locomotor task time 22.63.05.9-2.42.1-0.3-0.31.9-1.3-2.22.02.0-1.91.81.41.0
Vertical activity count, locomotor time 22.32.53.8-1.71.50.20.21.5-1.0-1.91.91.9-1.92.01.61.7
Light reinforcement 10.81.43.31.7-1.81.81.8-1.71.60.60.10.10.00.30.20.4
Light reinforcement 20.20.20.70.1-0.50.10.4-0.80.80.5-0.4-0.40.5-0.3-0.40.3
Bone: marrow area1.02.24.1-1.71.7-0.10.21.3-1.1-2.01.81.8-1.81.61.60.8
Bone: maximum diameter1.32.45.0-2.12.2-0.8-0.41.9-1.6-2.11.61.6-1.71.11.10.4
Bone: maximum force0.40.72.1-0.10.8-1.5-1.21.0-1.1-0.2-0.4-0.40.2-0.8-0.8-1.2
Bone: maximum moment0.40.72.0-0.30.9-1.4-1.11.0-1.1-0.3-0.2-0.20.1-0.7-0.7-1.0
Mean time between licks in bursts3.54.910.4-3.22.30.30.32.1-0.9-2.62.62.6-2.52.22.22.6
Mean num. licks in bursts1.01.24.6-2.11.9-1.2-1.11.2-1.2-1.00.50.5-0.50.20.40.5
Cd content in liver0.30.30.70.9-0.60.80.7-0.40.2-0.20.50.5-0.50.50.5-0.1
Co content in liver1.31.62.8-1.21.5-0.2-0.21.5-1.3-1.71.41.4-1.51.41.40.2
Cu content in liver1.62.03.9-1.31.00.80.51.0-0.4-1.61.71.7-1.72.02.01.5
Fe content in liver0.30.41.3-0.10.8-0.5-0.71.2-1.1-0.70.40.4-0.50.30.3-0.5
K content in liver0.50.51.20.3-0.91.00.9-1.11.10.50.00.00.1-0.0-0.01.0
Mg content in liver0.10.10.8-0.60.20.10.0-0.10.1-0.20.20.2-0.20.20.20.9
Mn content in liver1.41.62.51.5-1.3-0.2-0.2-1.40.61.6-1.5-1.51.5-1.5-1.5-1.2
Na content in liver0.60.71.2-0.3-0.4-0.1-0.2-0.80.91.1-1.0-1.01.1-0.9-1.00.8
Rb content in liver0.60.81.4-1.01.1-0.2-0.21.1-0.9-1.21.01.0-1.00.80.90.3
Se content in liver1.72.05.22.3-2.10.80.7-1.91.31.8-1.2-1.21.3-1.0-1.0-0.5
Sr content in liver0.40.41.0-0.00.6-1.0-1.00.7-1.0-0.0-0.4-0.40.2-0.4-0.4-0.8
Zn content in liver1.71.95.8-2.41.8-0.3-0.41.5-0.7-1.51.21.2-1.21.41.41.4
Bone: minimum diameter1.32.54.7-1.01.10.71.10.9-0.6-2.12.22.2-2.21.92.01.0
Time in familiar zone, hab. session 10.00.00.30.10.1-0.2-0.2-0.1-0.3-0.10.00.0-0.1-0.1-0.2-0.6
Time in novel zone, hab. session 10.40.40.70.2-0.30.90.80.10.5-0.30.60.6-0.50.70.90.7
Total zone transitions, hab. session 10.81.12.10.4-0.8-0.4-0.1-1.01.01.3-1.3-1.31.4-1.4-1.2-0.2
Total locomotion distance, hab. session 13.14.312.51.2-2.43.53.5-2.53.10.21.11.1-0.71.11.11.8
Locomotion velocity, hab. session 12.73.810.41.1-2.33.23.2-2.43.00.30.90.9-0.61.00.91.8
Time in familiar zone, hab. session 20.60.61.2-1.11.1-0.3-0.41.1-0.8-1.00.80.8-0.90.70.50.2
Time in novel zone, hab. session 20.00.00.10.20.0-0.2-0.20.1-0.20.0-0.2-0.20.1-0.00.1-0.2
Total zone transitions, hab. session 20.30.40.9-0.4-0.1-0.6-0.5-0.20.60.7-0.9-0.91.0-0.7-0.70.2
Total locomotion distance, hab. session 22.22.97.70.5-1.62.72.8-1.62.4-0.21.31.3-1.01.51.51.8
Locomotion velocity, hab. session 22.53.48.90.5-1.62.93.0-1.72.5-0.31.41.4-1.01.61.62.0
Novel to familiar place preference ratio0.10.10.3-0.2-0.20.10.2-0.40.50.2-0.1-0.10.2-0.5-0.20.1
Novelty place preference0.00.00.1-0.20.00.10.1-0.20.2-0.00.00.00.0-0.4-0.10.0
Time in novel zone, NPP test0.00.00.1-0.40.3-0.2-0.20.1-0.1-0.10.00.0-0.0-0.3-0.0-0.1
Total zone transitions, NPP test0.50.61.60.20.2-1.2-1.10.4-0.50.6-1.1-1.11.0-0.8-0.7-0.7
Total locomotion distance, NPP test1.42.05.21.0-1.42.32.3-1.11.7-0.31.11.1-0.91.41.31.2
Locomotion velocity, NPP test1.72.56.81.2-1.72.62.5-1.52.0-0.11.01.0-0.81.41.31.2
Intraocular pressure2.43.39.3-0.92.1-3.0-2.92.4-3.1-0.5-0.7-0.70.3-0.9-0.7-1.8
Delta distance traveled before/after self-admin0.50.51.10.3-0.70.20.3-0.91.11.0-0.8-0.80.9-0.6-0.60.6
Delta ambulatory time before/after self-admin0.80.81.70.4-0.7-0.3-0.3-0.90.81.3-1.3-1.31.3-1.0-1.0-0.1
Parametrial fat weight0.91.76.30.8-1.32.02.5-1.61.8-0.20.90.9-0.80.80.90.8
Pavlov. Cond. lever latency0.50.71.61.2-1.30.70.7-1.31.10.9-0.6-0.60.6-0.5-0.3-0.2
Pavlov. Cond. magazine entry latency1.21.53.2-1.81.6-0.5-0.41.5-0.9-1.61.31.3-1.31.11.20.6
Pavlov. Cond. change in total contacts1.01.03.0-1.11.4-0.8-0.81.7-1.3-1.20.80.8-0.90.70.5-0.1
Pavlov. Cond. index score1.62.03.7-1.91.9-0.6-0.51.8-1.3-1.81.41.4-1.51.31.30.7
Pavlov. Cond. latency score1.41.73.4-1.81.8-0.6-0.51.8-1.2-1.71.31.3-1.41.11.10.6
Pavlov. Cond. lever contacts0.80.91.7-1.21.3-0.5-0.41.3-1.1-1.21.01.0-1.00.90.80.2
Pavlov. Cond. magazine entry number1.41.84.02.0-1.90.70.6-1.71.21.6-1.2-1.21.3-1.1-1.2-0.7
Pavlov. Cond. intertrial magazine entries0.50.61.71.1-1.21.00.9-1.30.90.7-0.1-0.10.20.1-0.2-0.0
Pavlov. Cond. lever-magazine prob. diff.1.21.52.9-1.71.7-0.6-0.61.7-1.3-1.51.21.2-1.21.01.00.5
Pavlov. Cond. response bias0.60.81.2-1.01.0-0.2-0.10.9-0.8-1.11.01.0-1.01.01.00.5
Pavlov. Cond. lever latency7.410.027.85.3-5.03.43.2-4.53.43.0-1.3-1.31.6-1.6-1.7-1.3
Pavlov. Cond. magazine entry latency2.73.18.1-2.12.6-2.8-2.82.4-2.4-1.0-0.3-0.30.00.20.1-0.5
Pavlov. Cond. change in total contacts4.66.418.9-4.34.0-2.6-2.53.5-2.6-2.51.11.1-1.31.41.51.2
Pavlov. Cond. index score6.17.819.9-4.54.5-3.4-3.24.0-3.3-2.60.90.9-1.21.31.30.7
Pavlov. Cond. latency score5.56.817.3-4.14.2-3.4-3.23.7-3.1-2.20.70.7-0.91.01.00.5
Pavlov. Cond. lever contacts7.09.628.9-5.44.9-3.1-3.04.4-3.2-3.01.41.4-1.61.71.81.5
Pavlov. Cond. magazine entry number5.97.116.43.0-4.03.93.8-3.94.02.1-0.3-0.30.8-0.7-0.60.7
Pavlov. Cond. intertrial magazine entries2.22.97.0-0.5-0.72.52.6-0.81.7-0.91.81.8-1.51.71.92.1
Pavlov. Cond. lever-magazine prob. diff.5.87.418.9-4.34.3-3.2-3.13.9-3.2-2.61.01.0-1.31.41.30.7
Pavlov. Cond. response bias7.710.428.8-5.45.1-3.5-3.44.6-3.6-3.11.31.3-1.61.71.71.3
Time in closed arm before self-admin0.80.91.8-0.40.1-1.1-1.2-0.10.11.0-1.4-1.41.3-1.2-1.0-0.1
Time in closed arm after self-admin1.71.73.70.80.0-1.8-1.60.0-0.81.0-1.6-1.61.4-1.4-1.2-1.9
Time in open arm before self-admin0.70.72.61.6-1.41.21.3-1.10.80.50.10.10.00.20.3-0.1
Time in open arm after self-admin0.80.91.7-0.60.11.11.20.10.4-1.01.31.3-1.21.01.00.8
Bone: periosteal estimation1.53.16.2-1.92.2-0.5-0.12.1-1.8-2.52.02.0-2.11.61.60.4
Bone: periosteal perimeter1.22.03.8-1.91.8-0.4-0.11.5-1.2-1.91.61.6-1.61.21.30.9
Bone: post-yield work0.10.20.7-0.30.1-0.6-0.2-0.00.20.3-0.5-0.50.5-0.7-0.8-0.2
Progressive ratio test 1 active lever presses0.20.20.40.5-0.3-0.2-0.1-0.30.10.5-0.4-0.40.5-0.7-0.6-0.6
Progressive ratio test 1 breakpoint0.20.20.50.6-0.4-0.2-0.0-0.50.20.5-0.5-0.50.5-0.7-0.7-0.7
Progressive ratio test 1 inactive lever presses0.00.00.1-0.30.2-0.0-0.10.2-0.2-0.10.00.0-0.1-0.10.10.2
Progressive ratio test 2 active lever presses1.71.84.6-1.72.0-0.7-0.92.1-1.6-1.61.21.2-1.30.80.60.5
Progressive ratio test 2 breakpoint1.31.53.5-1.61.7-0.4-0.71.9-1.3-1.51.21.2-1.20.80.60.6
Progressive ratio test 2 inactive lever presses0.60.71.7-1.31.3-0.6-0.71.3-1.1-1.00.60.6-0.70.10.30.5
Incentive Sensitization - Responses2.52.55.6-2.02.2-0.5-0.92.4-1.6-1.91.51.5-1.61.20.91.0
Incentive Sensitization - Breakpoint2.32.35.4-2.02.2-0.5-0.92.3-1.6-1.81.41.4-1.51.10.81.0
Sum of active levers in priming session hrs 5-60.30.21.1-0.3-0.30.90.6-0.40.80.10.10.1-0.20.10.11.1
Progressive ratio0.80.93.3-0.00.7-1.8-1.70.8-1.40.2-0.8-0.80.6-0.5-0.3-1.2
Food seeking constrained by brief footshock1.41.75.2-1.70.90.60.70.50.3-1.21.31.3-1.11.41.92.3
Seeking ratio, punishment vs. effort2.22.77.3-1.20.02.32.1-0.31.5-1.11.81.8-1.51.61.62.7
Retroperitoneal fat weight3.712.231.91.5-1.85.45.6-1.72.2-2.54.34.3-4.03.53.11.9
Reaction time number correct0.81.22.40.5-1.00.00.1-1.31.31.5-1.4-1.41.5-1.1-0.8-0.2
Reaction time mean minus median0.60.81.9-1.20.80.10.50.40.0-1.01.01.0-0.90.91.11.4
Reaction time mean minus median AUC0.30.41.3-1.10.7-0.30.20.20.1-0.60.50.5-0.40.50.51.1
Reaction time num false alarms0.40.51.81.3-1.01.01.0-0.60.30.00.30.3-0.40.20.3-0.5
Reaction time num false alarms AUC0.10.20.91.0-0.60.30.3-0.3-0.10.2-0.0-0.0-0.1-0.2-0.0-0.6
Reaction time trials correct on left0.81.22.40.5-1.00.00.1-1.31.31.5-1.4-1.41.5-1.1-0.8-0.2
Reaction time trials on left0.81.22.30.5-1.00.00.1-1.31.31.5-1.4-1.41.5-1.1-0.8-0.1
Reaction time mean0.20.20.60.2-0.40.80.7-0.40.6-0.10.40.4-0.30.20.50.7
Reaction time mean AUC0.10.10.30.4-0.50.50.4-0.50.50.10.10.1-0.1-0.00.20.4
Median of all reaction times0.10.20.50.6-0.70.60.4-0.60.60.3-0.1-0.10.1-0.20.10.2
Reaction time omissions0.30.51.6-0.20.40.30.20.5-0.3-0.70.80.8-0.70.91.30.9
Reaction time false alarm rate0.20.20.80.9-0.20.20.20.3-0.7-0.50.50.5-0.70.30.2-0.6
Reaction time premature initiation rate2.93.96.2-1.40.72.02.10.40.5-2.02.52.5-2.42.32.52.4
Reaction time premature initiations1.42.04.2-1.10.21.61.7-0.11.0-1.11.51.5-1.31.61.82.1
Std. dev. reaction times0.91.32.3-1.00.60.70.80.40.1-1.31.41.4-1.41.21.51.4
Reaction time trials completed0.81.22.30.5-1.00.00.1-1.31.31.5-1.4-1.41.5-1.1-0.8-0.1
Reaction time trials AUC0.60.91.90.4-1.00.20.3-1.21.41.3-1.1-1.11.3-0.9-0.5-0.1
Run reversals in cocaine runway, females3.02.96.0-0.10.51.61.30.8-0.4-2.02.32.3-2.42.42.50.5
Run reversals in cocaine runway, males1.21.13.10.30.9-1.6-1.81.0-1.60.1-0.7-0.70.5-0.5-0.6-1.7
Latency to leave start box in cocaine runway0.90.92.31.5-1.51.31.2-1.31.30.8-0.2-0.20.4-0.10.10.0
Latency to leave start box in cocaine runway, F0.60.61.81.0-1.01.31.2-0.80.80.10.50.5-0.30.70.80.4
Latency to leave start box in cocaine runway, M1.21.12.01.1-1.20.30.1-1.11.11.4-1.2-1.21.3-1.2-1.1-0.4
Std. dev. time between licks in bursts2.12.66.9-1.40.31.61.7-0.10.9-1.31.81.8-1.62.01.92.6
Total sessions with >9 infusions0.50.51.5-1.01.1-1.1-1.21.0-0.7-0.2-0.1-0.10.2-0.4-0.20.3
Short access day 1 total inactive lever presses0.20.20.6-0.50.6-0.5-0.80.6-0.8-0.20.10.1-0.1-0.1-0.00.0
Short access day 10 total inactive lever presses0.70.82.10.5-1.11.20.9-1.21.40.7-0.1-0.10.4-0.2-0.41.5
Short access day 1 total infusions0.80.82.3-1.51.4-0.7-0.81.4-0.8-0.90.50.5-0.50.30.50.7
Short access day 10 total infusions0.70.81.9-0.71.3-0.9-0.81.4-1.3-1.00.60.6-0.70.40.4-0.4
Short access total infusions0.30.30.9-0.70.9-0.6-0.61.0-0.8-0.60.40.4-0.40.20.3-0.0
Short access day 1 locomotion1.21.34.5-0.91.3-1.9-2.11.2-1.30.3-0.8-0.80.9-0.8-0.6-0.1
Short access day 10 total locomotion0.10.10.2-0.40.5-0.20.10.2-0.2-0.40.40.4-0.3-0.1-0.00.2
Short access total locomotion0.10.10.40.1-0.2-0.2-0.0-0.20.30.4-0.3-0.30.5-0.6-0.60.3
One hour access (0.3 mA shock)1.61.94.2-1.91.9-0.7-0.92.1-1.5-1.51.31.3-1.21.00.90.9
Compulsive drug intake0.00.00.3-0.3-0.10.20.1-0.10.30.1-0.1-0.10.10.00.00.5
One hour access (shock baseline)0.80.92.2-1.41.5-0.9-0.91.5-1.2-0.90.70.7-0.60.30.30.5
Social response proportion1.21.33.60.9-1.51.71.8-1.71.90.60.20.20.1-0.1-0.00.7
Social responses1.21.64.50.8-1.12.12.0-1.01.3-0.31.11.1-0.90.91.31.3
Social time1.31.74.52.1-2.01.31.3-2.11.61.3-0.6-0.60.8-0.3-0.10.0
Soleus weight0.82.34.4-0.1-0.11.82.00.20.4-1.52.12.1-2.02.01.70.8
Bone: stiffness0.10.21.20.6-0.1-0.5-0.30.2-0.30.1-0.3-0.30.2-0.6-0.7-1.1
Tibialis anterior weight0.10.50.7-0.60.10.90.80.20.5-0.70.90.9-0.80.70.80.5
Time to tail flick, vehicle, before self-admin0.30.41.40.9-0.71.20.8-0.50.60.10.20.2-0.20.20.60.5
Time to tail flick, vehicle, after self-admin0.80.93.1-1.01.2-1.5-1.81.0-1.1-0.2-0.5-0.50.3-0.20.2-0.4
Time to tail flick, test, before self-admin0.70.74.2-0.30.8-0.7-0.50.8-1.1-0.80.40.4-0.60.30.3-2.0
Time to tail flick, test, after self-admin1.01.02.1-1.01.2-0.4-0.31.0-1.1-1.30.90.9-1.21.31.40.1
Delta time to tail flick, vehicle, before/after SA1.61.65.3-1.31.5-2.3-2.31.2-1.40.1-0.9-0.90.8-0.6-0.6-0.7
Delta time to tail flick, test, before/after SA0.30.31.90.1-0.40.30.2-0.50.60.4-0.3-0.30.30.20.21.4
Tibia length0.30.82.4-1.41.3-1.6-1.50.9-0.9-0.1-0.5-0.50.4-0.7-0.40.1
Ambulatory time before self-admin0.10.10.30.5-0.1-0.3-0.60.1-0.40.4-0.4-0.40.4-0.4-0.5-0.2
Ambulatory time after self-admin1.31.52.81.1-1.2-0.2-0.4-1.10.81.7-1.6-1.61.6-1.4-1.5-0.4
Bone: tissue strength2.52.55.71.3-1.4-0.4-0.3-1.31.11.9-1.8-1.81.9-2.3-2.4-0.9
Total heroin consumption0.10.10.40.20.1-0.2-0.60.2-0.20.1-0.3-0.30.2-0.0-0.3-0.2
Bone: trabecular number0.81.22.71.6-0.9-0.5-0.2-0.8-0.01.1-1.1-1.11.1-1.4-1.4-1.6
Bone: trabecular spacing0.30.41.9-1.40.8-0.3-0.40.3-0.2-0.30.10.1-0.10.60.61.3
Bone: trabecular thickness0.20.30.60.20.10.30.20.6-0.3-0.70.70.7-0.80.50.5-0.1
Bone: trabecular tissue density1.11.54.10.7-1.32.02.0-1.21.7-0.20.90.9-0.70.80.90.9
Water consumed over 24 hours0.80.92.01.2-1.40.90.8-1.41.21.1-0.6-0.60.7-0.9-0.8-0.3
Number of responses in last shaping day1.11.12.3-0.1-0.01.41.20.00.3-0.91.31.3-1.21.51.51.2