Gdpd4

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Liver	alternative polyA	XM_006229796.5	0.06	0.04	2.0e-05	0	0.01	0.01	0.01	7.7e-02	1.0e-02	1.2e-02	1.7e-02
2	BLA	gene expression	Gdpd4	0.18	0.12	7.6e-03	0.04	0.02	0.03	0.04	4.6e-03	2.8e-02	7.2e-03	5.5e-03
3	Brain	alternative polyA	XM_063280972.1	0.03	0.02	3.0e-03	0.03	0.01	0.01	0.02	6.4e-04	1.2e-02	1.5e-02	2.5e-03
4	PL	gene expression	Gdpd4	0.1	0.07	9.4e-03	0.01	0.02	0.01	0.01	4.7e-02	2.2e-03	1.4e-02	3.4e-02
5	Liver	gene expression	Gdpd4	0.45	0.13	2.1e-15	0.1	0.13	0.11	0.11	1.2e-11	7.6e-14	1.6e-12	5.9e-12

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5
Bone: apparent density	0.1	0.2	0.6	0.4	-0.1	-0.2	0.8	0.4
Area under the delay curve	0.3	0.5	1.6	-0.8	0.1	1.3	0.4	-0.1
BMI with tail	1.2	4.3	12.1	1.9	0.3	-3.5	-1.1	2.1
BMI without tail	0.9	4.7	12.9	1.6	1.1	-3.6	-2.0	1.6
Body weight	1.4	6.3	17.1	2.1	1.0	-4.1	-2.3	2.0
Weight adjusted by age	0.1	0.3	0.8	0.1	0.9	-0.5	-0.5	0.6
Bone surface	0.6	1.3	3.1	-1.4	1.8	0.9	-0.6	-0.3
Bone volume	0.2	0.4	1.3	-0.6	1.2	0.3	-0.1	0.3
Breakpoint value in progressive ratio session	0.4	0.7	2.0	0.5	-1.4	-0.2	1.1	0.3
Number of licking bursts	1.5	4.6	6.6	2.6	-1.8	-2.3	1.7	2.2
Context. condit. distance diff. score	1.5	1.9	3.3	-1.8	1.6	1.8	0.0	-0.5
Locomotion velocity, session 1	0.6	0.7	1.8	-0.7	-0.3	1.3	0.8	-0.6
Locomotion distance, session 1	0.6	0.8	1.1	-1.1	0.6	1.0	-0.6	-1.0
Locomotion velocity, session 2	0.4	0.4	0.8	-0.9	0.5	0.9	-0.3	-0.5
Locomotion distance, session 2	0.4	0.6	1.2	-0.6	0.6	0.4	-1.1	-1.0
Locomotion velocity, session 3	0.3	0.3	0.6	-0.7	0.6	0.7	-0.1	-0.5
Locomotion distance, session 3	0.9	1.0	2.2	-1.4	0.5	1.5	0.3	-0.6
Stereotopy head waving bouts, day 3	0.8	1.0	1.9	1.4	-0.7	-1.4	-0.7	-0.2
Stereotopy head waving duration, day 3	0.5	0.6	1.4	-0.3	0.6	0.2	-1.0	-1.2
Locomotion velocity, session 7	0.5	0.5	1.6	0.1	-0.5	0.4	1.2	0.9
Locomotion distance, session 7	0.4	0.5	1.6	-0.1	0.1	0.1	0.9	1.3
Stereotopy head waving bouts, day 7	1.8	2.1	4.6	-1.4	0.7	1.5	-1.1	-2.1
Stereotopy head waving duration, day 7	2.1	2.6	4.3	-1.6	1.4	1.3	-1.7	-2.1
Locomotion velocity, session 8	2.7	3.2	7.3	-2.3	1.6	2.7	0.7	-0.6
Locomotion distance, session 8	1.5	2.1	3.4	-1.8	1.5	1.7	-0.8	-1.2
Degree of sensitization distance	0.9	0.9	1.9	0.9	0.3	-1.4	-0.4	1.2
Degree of sensitization stereotypy	3.6	4.0	6.0	-2.4	1.3	2.3	-1.3	-2.4
Conditioned locomotion	0.1	0.2	0.3	-0.1	-0.5	0.6	0.4	-0.4
Cocaine response after cond. corrected	0.9	1.4	3.4	0.7	-0.9	-0.5	1.4	1.8
Cocaine response after cond. not corrected	0.2	0.3	0.8	0.2	-0.4	0.0	0.8	0.9
Cocaine response before conditioning	1.4	1.7	4.4	-0.9	0.7	1.0	-1.3	-2.1
Saline control response	1.4	2.0	4.3	-1.2	1.6	0.2	-2.1	-1.3
Bone: connectivity density	0.2	0.4	0.9	-0.5	0.3	0.9	0.7	-0.3
Bone: cortical apparent density	0.7	1.1	1.3	1.1	-1.1	-0.9	1.1	1.1
Bone: cortical area	0.4	0.7	1.3	0.1	1.1	-0.9	-0.3	1.1
Bone: cortical porosity	0.8	0.9	2.0	-0.7	0.2	0.9	-0.9	-1.4
Bone: cortical porosity	1.0	1.1	2.8	-0.7	0.1	1.0	-1.0	-1.7
Bone: cortical thickness	0.8	1.3	2.6	1.1	-0.5	-1.2	0.9	1.6
Bone: cortical thickness	0.1	0.2	0.6	-0.2	0.2	-0.0	0.3	0.8
Bone: cortical tissue density	0.7	1.0	1.4	1.0	-1.2	-0.8	1.1	0.9
Condit. Reinf. active minus inactive responses	0.7	0.7	1.9	0.6	0.6	-1.4	-0.3	1.0
Condit. Reinf. active-inactive response ratio	0.6	0.7	1.2	0.3	1.1	-1.1	-0.8	0.5
Condit. Reinf. active responses	0.5	0.6	1.6	0.8	0.1	-1.3	-0.0	0.9
Condit. Reinf. inactive responses	0.1	0.2	0.3	0.4	-0.6	-0.2	0.4	0.3
Incentive salience index mean	0.3	0.4	1.1	0.3	0.4	-0.8	0.1	1.1
Condit. Reinf. lever presses	0.1	0.1	0.3	-0.3	-0.0	0.4	0.5	0.4
Condit. Reinf. active minus inactive responses	3.7	5.7	12.2	-2.5	3.5	0.8	-2.8	-1.3
Condit. Reinf. active-inactive response ratio	0.4	0.6	1.5	-1.0	1.2	0.4	-0.5	0.3
Condit. Reinf. active responses	6.5	9.4	18.6	-3.0	4.3	1.0	-3.9	-1.8
Condit. Reinf. inactive responses	4.3	6.4	13.6	-2.0	3.1	0.6	-3.7	-2.2
Condit. Reinf. lever presses	14.8	21.4	31.0	-5.3	5.6	3.3	-4.8	-3.9
Condit. Reinf. lever reinforcers received	7.3	10.3	20.0	-3.2	4.5	1.1	-4.0	-1.9
Conditioned reinforcement - actives	0.3	1.3	2.3	-1.5	1.0	1.4	-0.5	-1.1
Conditioned reinforcement - inactives	0.1	0.3	0.6	-0.1	-0.8	0.7	0.6	-0.5
Conditioned locomotion	2.0	3.0	6.1	-2.2	0.9	2.5	-0.5	-1.8
Patch foraging indifference point 0 sec	2.3	6.4	8.8	-2.5	3.0	1.4	-3.0	-2.4
Patch foraging indifference point AUC	0.0	0.1	0.2	-0.1	0.4	-0.3	-0.0	0.5
Delay disc. indifference point, 0s delay	0.8	0.9	1.3	-1.1	1.1	0.7	-1.2	-0.7
Delay disc. indifference point, 16s delay	0.4	0.6	1.7	-0.4	-0.5	1.3	0.8	-0.1
Delay disc. indifference point, 2s delay	1.5	1.6	2.0	-1.4	1.3	1.4	-1.0	-1.1
Delay disc. indifference point, 24s delay	0.8	1.3	2.4	0.8	-1.4	-0.2	1.6	1.2
Delay disc. indifference point, 4s delay	0.9	1.0	1.6	-1.3	1.2	1.0	-0.8	-0.2
Delay disc. indifference point, 8s delay	0.2	0.4	0.9	-0.8	0.2	1.0	0.4	-0.2
Indifference point function ln k	0.7	2.1	3.7	-1.4	0.9	1.7	-1.1	-1.9
Indifference point function log k	0.7	2.1	3.7	-1.4	0.9	1.7	-1.1	-1.9
Patch foraging total patch changes 0 sec	1.8	5.3	7.4	-2.4	2.7	1.3	-2.6	-2.2
Patch foraging total patch changes 12 sec	0.7	1.0	2.4	-0.7	1.5	-0.3	-1.4	-0.3
Patch foraging total patch changes 18 sec	0.9	2.2	5.5	-1.4	2.3	0.2	-1.8	-0.8
Patch foraging total patch changes 24 sec	0.2	0.6	1.3	-0.6	1.1	-0.4	-1.1	-0.3
Patch foraging total patch changes 6 sec	0.8	1.4	2.3	-1.1	1.5	0.5	-1.3	-1.1
Patch foraging time to switch 0 sec	1.2	4.5	7.5	2.5	-2.7	-1.3	2.1	1.5
Patch foraging water rate 0 sec	1.2	4.5	6.5	-2.5	2.5	1.4	-2.1	-1.8
Patch foraging water rate 12 sec	0.8	3.1	4.3	-2.1	1.9	1.5	-1.4	-1.8
Patch foraging water rate 18 sec	0.3	0.7	1.3	-1.1	1.1	0.6	-0.7	-0.5
Patch foraging water rate 24 sec	1.0	1.5	2.6	-1.6	0.8	1.6	-0.1	-1.2
Patch foraging water rate 6 sec	0.7	1.0	1.6	-1.2	0.6	1.2	-0.3	-1.2
Seeking ratio, delayed vs. immediate footshock	1.5	2.2	4.1	1.2	-1.5	-0.3	2.0	1.8
Distance traveled before self-admin	0.2	0.4	0.5	0.7	-0.5	-0.4	0.7	0.6
Distance traveled after self-admin	0.5	0.8	2.5	0.9	-1.6	-0.2	0.7	-0.3
Extensor digitorum longus weight	0.3	1.1	3.3	0.8	0.2	-1.3	0.1	1.8
Bone: elastic displacement	1.1	1.4	2.9	1.0	-1.3	-0.3	1.7	1.1
Bone: elastic work	1.6	2.1	5.3	0.9	-1.7	0.2	2.3	1.1
Bone: endosteal estimation	0.5	1.2	3.3	-1.0	1.8	-0.1	-1.4	-0.0
Bone: endosteal perimeter	1.0	2.5	5.4	-1.9	2.3	0.8	-1.6	-0.7
Epididymis fat weight	0.7	3.6	7.8	2.1	-1.0	-2.8	0.3	2.1
Delta time in closed arm before/after self-admin	1.2	1.1	2.8	0.7	-0.4	-0.8	1.2	1.7
Delta time in open arm before/after self-admin	1.5	1.8	3.3	-1.5	1.8	0.4	-1.5	-0.9
Diff in mean of infusions in LGA sessions	2.9	5.2	8.0	2.6	-2.8	-1.8	2.2	1.8
Delay discount exponential model param	0.3	0.4	1.5	0.8	-0.1	-1.2	-0.3	0.2
Extinction: sum of active levers before priming	0.1	0.1	0.2	-0.3	0.3	-0.4	-0.4	0.1
Active lever presses in extinction session 6	3.2	3.2	8.1	-1.6	0.4	1.8	-1.4	-2.8
Bone: final force	0.1	0.2	0.6	0.0	0.3	-0.0	0.7	0.8
Bone: final moment	0.1	0.2	0.4	-0.1	0.5	-0.1	0.4	0.6
Food consumed during 24 hour testing period	2.3	4.7	7.9	-2.4	1.5	2.3	-1.5	-2.8
Glucose	0.1	0.2	0.9	-0.1	0.0	-0.3	0.4	0.9
Heart weight	0.3	0.4	0.9	-0.7	1.0	0.3	-0.7	-0.4
Delay discount hyperbolic model param	0.4	0.5	1.5	0.8	-0.3	-1.2	-0.1	0.1
Intermittent access intake day 1-15 change	0.5	2.8	4.5	-1.9	1.2	2.1	-0.9	-1.9
Intermittent access intake escalation	0.6	3.1	5.2	-2.1	1.3	2.3	-0.9	-1.9
Intermittent access intake escalation 2	1.0	1.6	2.5	-1.4	1.0	1.6	-0.8	-1.4
Intermitt. access day 1 inactive lever presses	0.1	1.8	4.3	1.3	-2.1	-0.2	1.6	0.8
Intermitt. access day 15 inactive lever presses	0.3	1.8	4.0	1.5	-2.0	-0.4	1.4	0.7
Intermitt. access escalation Index	0.1	0.2	0.6	0.2	-0.4	0.1	0.8	0.1
Intermittent access day 1 total infusions	0.2	0.7	1.5	-1.2	0.7	1.2	-0.1	-0.5
Intermittent access day 15 total infusions	1.5	3.6	7.6	-2.4	1.3	2.8	-0.5	-1.7
Intermittent access terminal intake (last 3 days)	1.7	2.9	5.1	-2.0	1.5	2.2	-0.9	-1.5
Intermittent access total infusions	1.2	1.4	2.3	-1.5	1.2	1.5	-0.5	-0.8
Intermittent access day 1 locomotion	0.2	0.3	1.0	-0.6	0.0	1.0	0.4	-0.4
Intermittent access day 15 total locomotion	0.7	2.7	4.4	-1.7	1.1	2.1	-1.1	-1.9
Intermittent access total locomotion	0.8	1.0	1.6	-1.1	0.9	1.3	-0.6	-1.0
Intermittent access standard deviation	0.0	0.2	0.8	-0.2	0.6	-0.2	-0.9	0.0
Left kidney weight	0.3	2.1	4.7	0.7	1.3	-1.9	-2.2	0.3
Right kidney weight	0.3	2.4	6.2	0.5	1.4	-1.9	-2.5	0.2
Cocaine induced anxiety	0.7	2.0	3.4	1.9	-1.5	-1.2	1.0	1.3
Post-drug Anxiety	1.4	1.6	2.2	1.4	-1.5	-0.7	1.3	1.3
Baseline Anxiety	0.3	0.5	1.1	-1.0	0.6	1.0	0.1	-0.2
Tail length	0.5	2.9	5.8	0.5	1.8	-2.2	-2.4	0.7
Length with tail	0.8	3.4	7.2	1.0	1.5	-2.7	-2.4	0.9
Length without tail	0.2	0.9	2.5	1.2	-0.5	-1.6	-0.6	0.3
Times rat made contact with spout	0.4	0.4	1.1	0.9	-0.1	-1.1	-0.2	0.3
Lifetime Intake	1.5	1.8	3.2	-1.7	1.2	1.8	-0.5	-1.0
Liver weight, left	0.4	0.8	1.9	0.7	-0.1	-1.4	-0.6	1.0
Liver weight, right	2.0	3.6	8.9	2.2	-0.4	-3.0	-0.7	1.9
Locomotor activity	1.3	2.0	4.5	-0.6	1.3	0.2	-2.1	-1.8
Locomotor testing distance	1.1	2.7	6.9	-0.8	2.0	-0.3	-2.6	-1.2
Locomotor testing rearing	0.4	1.6	3.8	0.4	1.1	-1.7	-2.0	0.0
Locomotion in novel chamber	1.0	1.4	2.6	-1.5	0.5	1.6	-0.5	-1.2
Locomotion in novel chamber post-restriction	1.4	4.1	6.9	-2.6	1.4	2.4	-1.0	-2.1
Fecal boli incidents, locomotor time 1	0.6	1.5	3.6	-1.5	1.0	1.9	0.2	-0.8
Change in fecal boli incidents, locomotor task	0.6	0.6	1.6	1.1	-1.3	-0.7	0.2	0.1
Time >=10cm from walls, locomotor time 1	1.2	1.5	3.0	-1.7	0.9	0.9	-0.7	-1.6
Bouts of movement, locomotor time 1	0.2	0.2	0.6	-0.6	0.4	0.8	-0.1	-0.1
Total resting periods, locomotor time 1	0.2	0.3	0.9	-0.5	0.1	1.0	0.4	-0.1
Rest time, locomotor task time 1	0.3	0.5	0.8	-0.4	-0.9	0.9	0.9	-0.1
Distance moved, locomotor task time 1	0.2	0.6	1.5	0.1	1.2	-0.7	-0.8	0.5
Vertical activity count, locomotor time 1	0.1	0.4	1.4	-0.2	1.2	-0.0	-0.8	0.2
Time >=10cm from walls, locomotor time 2	0.3	0.7	1.3	-1.2	1.1	0.1	-1.0	-0.6
Bouts of movement, locomotor time 2	0.5	1.5	2.4	-0.9	1.3	1.2	-1.6	-1.0
Total resting periods, locomotor time 2	0.3	1.1	1.4	-0.7	1.1	1.2	-1.2	-0.8
Rest time, locomotor task time 2	0.9	1.4	1.9	1.4	-1.2	-1.0	1.4	0.9
Distance moved, locomotor task time 2	1.3	1.7	3.2	-1.5	1.8	0.4	-1.6	-0.6
Vertical activity count, locomotor time 2	0.3	0.7	1.5	-0.8	1.2	0.6	-1.1	0.0
Light reinforcement 1	0.5	2.4	3.8	1.9	-1.4	-1.9	0.8	1.5
Light reinforcement 2	0.1	0.1	0.3	0.0	-0.2	-0.3	-0.5	-0.5
Bone: marrow area	0.4	1.1	2.8	-0.9	1.7	-0.2	-1.3	0.0
Bone: maximum diameter	1.0	2.1	5.7	-1.4	2.4	0.1	-1.6	-0.3
Bone: maximum force	0.1	0.2	0.6	-0.3	0.2	0.3	0.8	0.6
Bone: maximum moment	0.1	0.2	0.3	-0.4	0.4	0.2	0.5	0.4
Mean time between licks in bursts	0.7	3.9	7.9	-1.6	2.7	0.5	-2.8	-1.3
Mean num. licks in bursts	1.4	3.7	5.1	-2.3	1.9	1.9	-1.6	-1.9
Cd content in liver	1.2	1.3	2.7	1.0	-0.3	-1.5	0.5	1.7
Co content in liver	0.5	0.5	1.5	-0.7	1.2	0.1	-0.8	-0.1
Cu content in liver	0.5	0.6	1.3	0.3	0.5	-1.1	-1.2	0.4
Fe content in liver	0.0	0.1	0.2	0.1	-0.1	-0.1	0.3	0.4
K content in liver	0.2	0.2	0.4	0.4	-0.7	-0.0	-0.2	-0.5
Mg content in liver	0.3	0.4	1.0	-0.4	-0.0	0.6	-0.7	-1.0
Mn content in liver	0.7	0.8	2.4	0.5	-1.5	0.4	1.0	-0.2
Na content in liver	1.4	1.5	3.5	-0.9	0.6	1.2	-1.2	-1.9
Rb content in liver	0.0	0.1	0.1	0.1	0.3	-0.2	-0.3	0.1
Se content in liver	4.1	4.8	10.4	2.3	-3.2	-1.2	2.3	1.4
Sr content in liver	0.2	0.2	0.3	-0.6	0.3	0.5	0.3	-0.1
Zn content in liver	1.4	1.7	3.8	-1.0	1.8	0.1	-1.9	-0.6
Bone: minimum diameter	0.5	1.0	1.8	0.2	1.2	-1.3	-0.7	1.1
Time in familiar zone, hab. session 1	0.1	0.1	0.2	0.1	-0.4	0.0	0.5	0.4
Time in novel zone, hab. session 1	0.3	0.3	0.7	0.6	0.3	-0.8	-0.2	0.5
Total zone transitions, hab. session 1	0.2	0.3	1.2	-0.2	0.4	0.4	-0.3	-1.1
Total locomotion distance, hab. session 1	2.5	3.5	9.4	2.5	-0.5	-3.1	-0.8	1.1
Locomotion velocity, hab. session 1	2.0	2.8	7.5	2.2	-0.3	-2.7	-0.9	0.8
Time in familiar zone, hab. session 2	0.5	0.5	1.0	-0.8	1.0	0.5	-0.8	-0.4
Time in novel zone, hab. session 2	0.1	0.1	0.2	0.1	-0.4	-0.0	0.4	0.4
Total zone transitions, hab. session 2	0.9	1.2	2.5	-0.9	0.9	0.7	-1.1	-1.6
Total locomotion distance, hab. session 2	1.6	2.1	5.9	1.7	-0.0	-2.4	-1.2	0.6
Locomotion velocity, hab. session 2	1.8	2.4	6.8	1.8	-0.1	-2.6	-1.2	0.7
Novel to familiar place preference ratio	0.1	0.1	0.4	-0.2	0.1	-0.1	-0.6	-0.4
Novelty place preference	0.0	0.1	0.2	-0.2	0.0	-0.1	-0.4	-0.2
Time in novel zone, NPP test	0.1	0.1	0.2	-0.4	0.3	0.2	-0.4	-0.3
Total zone transitions, NPP test	0.2	0.3	0.8	-0.6	-0.0	0.9	0.4	-0.5
Total locomotion distance, NPP test	1.8	2.5	5.5	1.9	-0.9	-2.3	-0.1	1.5
Locomotion velocity, NPP test	2.3	3.3	7.2	2.3	-1.2	-2.7	-0.0	1.6
Intraocular pressure	1.3	2.1	5.3	-1.8	0.7	2.3	1.3	-0.1
Delta distance traveled before/after self-admin	0.9	1.0	3.1	-0.5	0.1	0.8	-1.0	-1.8
Delta ambulatory time before/after self-admin	0.5	0.8	2.7	-0.6	-0.1	0.8	-0.8	-1.6
Parametrial fat weight	0.7	1.5	4.7	1.5	-0.2	-2.2	-0.3	0.8
Pavlov. Cond. lever latency	0.7	0.9	1.3	1.2	-1.1	-1.1	0.5	0.6
Pavlov. Cond. magazine entry latency	1.7	2.2	4.7	-1.5	2.2	0.7	-1.7	-0.9
Pavlov. Cond. change in total contacts	0.5	0.5	1.0	-1.0	0.9	0.8	-0.3	-0.1
Pavlov. Cond. index score	1.2	1.5	3.1	-1.3	1.8	0.8	-1.2	-0.6
Pavlov. Cond. latency score	1.1	1.4	3.0	-1.3	1.7	0.8	-1.2	-0.6
Pavlov. Cond. lever contacts	0.4	0.5	1.0	-0.8	1.0	0.8	-0.5	-0.3
Pavlov. Cond. magazine entry number	1.8	2.3	5.1	1.5	-2.2	-0.8	1.6	0.8
Pavlov. Cond. intertrial magazine entries	1.3	1.5	3.2	1.4	-1.8	-1.0	1.0	0.9
Pavlov. Cond. lever-magazine prob. diff.	1.0	1.2	2.3	-1.3	1.5	0.9	-1.0	-0.6
Pavlov. Cond. response bias	0.5	0.6	1.5	-0.8	1.2	0.6	-0.7	-0.3
Pavlov. Cond. lever latency	16.3	22.9	32.5	5.7	-5.4	-3.9	4.6	4.1
Pavlov. Cond. magazine entry latency	3.7	5.2	9.4	-3.1	2.3	2.6	-1.3	-1.8
Pavlov. Cond. change in total contacts	6.1	14.8	20.3	-4.5	4.5	2.8	-4.0	-3.2
Pavlov. Cond. index score	10.3	16.2	24.6	-5.0	4.6	3.4	-3.6	-3.3
Pavlov. Cond. latency score	9.1	14.5	22.4	-4.7	4.2	3.4	-3.3	-3.2
Pavlov. Cond. lever contacts	14.2	21.0	29.6	-5.4	5.2	3.6	-4.5	-3.9
Pavlov. Cond. magazine entry number	5.7	7.4	14.9	3.9	-2.8	-3.2	1.2	1.6
Pavlov. Cond. intertrial magazine entries	0.6	1.3	2.7	0.9	0.8	-1.6	-1.6	0.0
Pavlov. Cond. lever-magazine prob. diff.	9.7	14.9	22.8	-4.8	4.4	3.3	-3.5	-3.1
Pavlov. Cond. response bias	15.1	20.9	31.2	-5.6	5.2	3.9	-4.1	-3.7
Time in closed arm before self-admin	0.6	1.0	1.8	-0.9	0.3	1.4	-0.5	-1.4
Time in closed arm after self-admin	1.1	1.2	3.3	0.1	-1.2	1.1	1.8	0.4
Time in open arm before self-admin	1.7	2.1	2.9	1.7	-1.5	-1.3	1.2	1.4
Time in open arm after self-admin	0.6	0.7	1.4	0.1	0.8	-1.2	-1.2	0.0
Bone: periosteal estimation	0.5	1.1	3.3	-0.8	1.8	-0.4	-1.0	0.7
Bone: periosteal perimeter	0.7	1.3	3.5	-1.0	1.9	-0.0	-1.4	-0.3
Bone: post-yield work	0.1	0.2	0.5	-0.2	0.7	-0.1	-0.4	-0.4
Progressive ratio test 1 active lever presses	0.1	0.3	0.6	-0.2	-0.3	0.7	0.8	-0.2
Progressive ratio test 1 breakpoint	0.2	0.3	0.7	-0.2	-0.3	0.7	0.8	-0.1
Progressive ratio test 1 inactive lever presses	0.2	0.4	0.8	0.5	-0.9	0.4	0.9	-0.1
Progressive ratio test 2 active lever presses	0.5	0.7	1.4	-1.2	1.1	1.0	-0.3	-0.2
Progressive ratio test 2 breakpoint	0.6	0.8	1.5	-1.2	1.1	1.1	-0.2	-0.1
Progressive ratio test 2 inactive lever presses	0.1	0.3	0.6	-0.6	0.5	0.8	-0.1	-0.2
Incentive Sensitization - Responses	0.6	1.6	2.8	-1.4	1.7	1.3	-1.0	-0.5
Incentive Sensitization - Breakpoint	0.6	1.5	2.5	-1.4	1.6	1.3	-1.0	-0.5
Sum of active levers in priming session hrs 5-6	0.5	0.4	1.3	-0.1	-0.0	0.3	-1.1	-0.9
Progressive ratio	0.2	0.5	1.1	-1.0	0.1	1.1	0.7	-0.1
Food seeking constrained by brief footshock	2.4	3.0	7.1	-1.3	1.8	0.0	-2.7	-1.6
Seeking ratio, punishment vs. effort	0.9	2.1	6.7	0.1	1.3	-1.0	-2.6	-0.9
Retroperitoneal fat weight	3.4	15.4	39.2	4.4	-0.9	-6.3	-0.5	4.1
Reaction time number correct	0.2	0.7	2.7	-0.2	-0.3	0.4	-0.6	-1.6
Reaction time mean minus median	0.2	1.4	2.9	-0.9	1.6	0.4	-1.7	-0.8
Reaction time mean minus median AUC	0.3	1.8	3.0	-1.1	1.5	0.7	-1.7	-1.3
Reaction time num false alarms	2.3	4.0	5.6	2.0	-1.9	-1.9	1.8	2.4
Reaction time num false alarms AUC	1.0	2.2	3.0	1.4	-1.6	-1.0	1.6	1.7
Reaction time trials correct on left	0.2	0.7	2.7	-0.2	-0.3	0.4	-0.6	-1.6
Reaction time trials on left	0.2	0.7	2.8	-0.3	-0.3	0.5	-0.6	-1.7
Reaction time mean	0.1	0.2	0.3	0.6	-0.2	-0.6	-0.2	0.6
Reaction time mean AUC	0.1	0.4	0.6	0.7	-0.6	-0.5	0.3	0.8
Median of all reaction times	0.3	0.5	0.7	0.8	-0.8	-0.6	0.4	0.8
Reaction time omissions	0.1	0.2	0.5	-0.3	0.7	0.1	-0.7	0.3
Reaction time false alarm rate	2.3	3.2	6.5	1.4	-1.5	-1.2	2.0	2.5
Reaction time premature initiation rate	1.3	2.0	4.8	-0.1	2.0	-1.2	-2.2	0.1
Reaction time premature initiations	0.7	2.0	5.5	-0.3	1.8	-0.6	-2.4	-0.9
Std. dev. reaction times	0.2	0.6	1.6	-0.3	1.1	-0.3	-1.3	0.1
Reaction time trials completed	0.2	0.7	2.8	-0.3	-0.3	0.5	-0.6	-1.7
Reaction time trials AUC	0.2	0.7	2.6	-0.2	-0.1	0.3	-0.8	-1.6
Run reversals in cocaine runway, females	1.3	1.5	3.6	1.1	0.2	-1.7	0.2	1.9
Run reversals in cocaine runway, males	0.5	0.6	1.2	-0.7	0.3	1.1	1.1	0.1
Latency to leave start box in cocaine runway	1.8	2.5	4.6	1.9	-2.2	-1.5	1.0	1.1
Latency to leave start box in cocaine runway, F	2.1	2.6	4.1	2.0	-1.6	-1.9	0.8	1.5
Latency to leave start box in cocaine runway, M	0.4	0.4	1.5	0.2	-1.2	0.3	0.5	-0.3
Std. dev. time between licks in bursts	0.8	1.4	4.5	-0.0	1.1	-1.0	-2.1	-0.7
Total sessions with >9 infusions	1.5	1.8	2.8	-1.7	1.3	1.6	-0.8	-1.2
Short access day 1 total inactive lever presses	0.1	0.3	0.9	-0.7	0.1	0.9	0.2	-0.2
Short access day 10 total inactive lever presses	0.2	1.3	2.6	1.6	-1.6	-0.8	0.8	0.5
Short access day 1 total infusions	1.5	3.0	4.5	-2.0	2.1	1.5	-1.6	-1.4
Short access day 10 total infusions	0.5	0.8	1.8	-1.3	0.9	1.1	-0.2	-0.5
Short access total infusions	1.4	2.0	3.5	-1.9	1.3	1.8	-0.7	-1.1
Short access day 1 locomotion	2.1	3.5	6.1	-2.3	1.5	2.5	-0.7	-1.8
Short access day 10 total locomotion	0.4	1.6	2.2	-1.5	1.2	1.4	-1.1	-1.1
Short access total locomotion	0.8	1.2	2.4	-1.1	0.6	1.6	-0.6	-1.3
One hour access (0.3 mA shock)	0.7	0.8	1.4	-1.2	1.1	0.9	-0.7	-0.6
Compulsive drug intake	0.2	0.2	0.7	0.5	-0.8	0.2	0.3	-0.3
One hour access (shock baseline)	0.7	1.8	3.3	-1.8	1.3	1.6	-0.7	-1.0
Social response proportion	0.7	0.9	1.9	1.4	-0.8	-1.3	-0.5	0.2
Social responses	1.2	1.6	3.3	1.6	-0.7	-1.8	-0.1	1.2
Social time	1.8	2.8	5.5	2.0	-2.4	-1.2	1.2	1.2
Soleus weight	0.7	2.1	5.0	1.5	0.2	-2.2	-0.4	1.7
Bone: stiffness	0.3	0.5	1.0	0.6	-0.3	-0.6	1.0	1.0
Tibialis anterior weight	0.1	0.5	1.2	0.2	0.7	-0.8	-1.1	0.0
Time to tail flick, vehicle, before self-admin	0.1	0.1	0.3	0.2	0.3	0.3	0.2	0.6
Time to tail flick, vehicle, after self-admin	0.6	1.2	1.7	-1.2	1.3	1.1	-0.8	-0.9
Time to tail flick, test, before self-admin	0.7	0.8	2.5	-0.2	0.9	-1.6	0.1	0.9
Time to tail flick, test, after self-admin	0.2	0.2	0.4	-0.1	0.5	-0.4	-0.4	0.6
Delta time to tail flick, vehicle, before/after SA	1.2	1.3	1.9	-1.4	1.0	1.0	-0.8	-1.4
Delta time to tail flick, test, before/after SA	0.3	0.3	0.8	0.6	-0.9	0.5	-0.1	-0.4
Tibia length	0.9	2.5	3.7	-1.9	1.6	1.5	-1.2	-1.7
Ambulatory time before self-admin	0.2	0.6	1.7	0.5	-0.9	0.0	1.3	0.6
Ambulatory time after self-admin	0.4	0.6	1.9	0.3	-1.4	0.4	0.6	-0.7
Bone: tissue strength	0.3	0.3	0.7	0.7	-0.7	-0.0	0.8	-0.2
Total heroin consumption	0.1	0.1	0.2	0.2	-0.4	-0.4	-0.0	0.0
Bone: trabecular number	0.8	1.6	3.7	1.1	-1.2	-0.3	1.9	1.3
Bone: trabecular spacing	1.3	1.9	3.0	-1.4	1.2	1.0	-1.5	-1.7
Bone: trabecular thickness	0.7	0.9	2.1	1.0	-0.5	-1.1	0.6	1.4
Bone: trabecular tissue density	1.2	2.1	5.3	1.9	-0.9	-2.3	-0.2	0.9
Water consumed over 24 hours	0.3	0.6	1.0	1.0	-0.9	-0.6	0.7	0.5
Number of responses in last shaping day	1.9	2.5	4.5	1.8	-0.7	-2.1	0.7	1.9