Hub : Traits

Bouts of movement, locomotor time 2

Number of bouts of movement during the session, when each movement bout was separated by a period of inactivity lasting 1s or longer in time2

Tags: Behavior · Locomotion

Project: u01_suzanne_mitchell

1 significantly associated model · 1 unique gene

Significant Loci

# chr p0 p1 # assoc genes # joint models best TWAS P best SNP P cond SNP P % var exp joint genes
1 9 24497174 25018277 1 1 9.7e-08 0.0048 1 100 Rims1

p0: physical position of the start of the locus. p1: physical position of the end of the locus. # joint models: number of models selected by step-wise conditional analysis.

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Right kidney weight 1.9 1 0 0 0 1 Rims1
Liver weight, right 3.2 1 0 0 0 1 Rims1
Indifference point function ln k 3.2 1 0 0 0 1 Rims1
Indifference point function log k 3.2 1 0 0 0 1 Rims1
Delay discounting water rate 12 sec 2.7 1 0 0 0 1 Rims1
Delay discounting water rate 24 sec 3.2 1 0 0 0 1 Rims1
Light reinforcement 1 2.1 1 0 0 0 1 Rims1
Light reinforcement 2 7.7 1 0 0 0 1 Rims1
Conditioned reinforcement - inactives 5.5 1 0 0 0 1 Rims1
Intermitt. access day 1 inactive lever presses 15.1 1 0 0 0 1 Rims1
Intermitt. access day 15 inactive lever presses 7.7 1 0 0 0 1 Rims1
Intermitt. access escalation Index 4.6 1 0 0 0 1 Rims1
Intermittent access total infusions 4.7 1 0 0 0 1 Rims1
Lifetime Intake 4.5 1 0 0 0 1 Rims1
Incentive Sensitization - Responses 8.4 1 0 0 0 1 Rims1
Incentive Sensitization - Breakpoint 6.3 1 0 0 0 1 Rims1
Progressive ratio test 1 active lever presses 11.7 1 0 0 0 1 Rims1
Progressive ratio test 1 breakpoint 14.1 1 0 0 0 1 Rims1
Progressive ratio test 2 active lever presses 14.2 1 0 0 0 1 Rims1
Progressive ratio test 2 breakpoint 16.4 1 0 0 0 1 Rims1
Short access day 10 total inactive lever presses 29.5 1 1 100 0 1 Rims1
Short access total infusions 5.5 1 0 0 0 1 Rims1
Short access day 1 locomotion 3.7 1 0 0 0 1 Rims1
One hour access (0.3 mA shock) 4.8 1 0 0 0 1 Rims1
Locomotion velocity, session 1 4.1 1 0 0 0 1 Rims1
Locomotion velocity, session 2 3.4 1 0 0 0 1 Rims1
Locomotion velocity, session 3 6.6 1 0 0 0 1 Rims1
Bone: tissue strength 4.3 1 0 0 0 1 Rims1
Distance traveled before self-admin 5.8 1 0 0 0 1 Rims1
Distance traveled after self-admin 5.0 1 0 0 0 1 Rims1
Diff in mean of infusions in LGA sessions 4.0 1 0 0 0 1 Rims1
Extinction: sum of active levers before priming 27.4 1 1 100 0 1 Rims1
Delta distance traveled before/after self-admin 12.2 1 0 0 0 1 Rims1
Delta ambulatory time before/after self-admin 5.3 1 0 0 0 1 Rims1
Time in closed arm after self-admin 7.5 1 0 0 0 1 Rims1
Time to tail flick, vehicle, before self-admin 9.4 1 0 0 0 1 Rims1
Time >=10cm from walls, locomotor time 1 29.0 1 1 100 0 1 Rims1
Bouts of movement, locomotor time 1 6.0 1 0 0 0 1 Rims1
Total resting periods, locomotor time 1 7.0 1 0 0 0 1 Rims1
Vertical activity count, locomotor time 1 6.1 1 0 0 0 1 Rims1
Total resting periods, locomotor time 2 30.9 1 1 100 0 1 Rims1
Rest time, locomotor task time 2 4.5 1 0 0 0 1 Rims1
Distance moved, locomotor task time 2 3.5 1 0 0 0 1 Rims1
Locomotion in novel chamber post-restriction 5.2 1 0 0 0 1 Rims1
Fe content in liver 3.3 1 0 0 0 1 Rims1

chisq ratio: Average Chi2 statistic for the selected genes in the secondary trait, divided by the average statistic for all genes in the secondary trait. # genes+: Shared significant genes at Bonferroni correction. # genes++: Shared significant genes at transcriptome-wide significance. % genes++: Number of [++] genes as a percentage of primary trait’s total joint genes. corr: Correlation of effect sizes across the [+] genes.

Associations by panel

tissue modality # hits % hits/tests avg chisq
Adipose alternative polyA 0 0.000 1.00
Adipose alternative TSS 0 0.000 1.09
Adipose gene expression 0 0.000 1.05
Adipose isoform ratio 0 0.000 1.06
Adipose intron excision ratio 0 0.000 1.17
Adipose mRNA stability 0 0.000 1.04
BLA alternative polyA 0 0.000 1.02
BLA alternative TSS 0 0.000 1.19
BLA gene expression 0 0.000 1.07
BLA isoform ratio 0 0.000 1.07
BLA intron excision ratio 0 0.000 1.11
BLA mRNA stability 0 0.000 1.06
Brain alternative polyA 0 0.000 1.14
Brain alternative TSS 0 0.000 1.14
Brain gene expression 0 0.000 1.08
Brain isoform ratio 0 0.000 1.06
Brain intron excision ratio 0 0.000 1.13
Brain mRNA stability 0 0.000 1.02
Eye alternative polyA 0 0.000 1.29
Eye alternative TSS 0 0.000 1.19
Eye gene expression 0 0.000 1.07
Eye isoform ratio 0 0.000 1.24
Eye intron excision ratio 0 0.000 1.23
Eye mRNA stability 0 0.000 1.10
IL alternative polyA 0 0.000 1.01
IL alternative TSS 0 0.000 1.15
IL gene expression 0 0.000 1.08
IL isoform ratio 0 0.000 1.16
IL intron excision ratio 0 0.000 1.03
IL mRNA stability 0 0.000 1.05
LHb alternative polyA 0 0.000 1.02
LHb alternative TSS 0 0.000 1.16
LHb gene expression 0 0.000 1.09
LHb isoform ratio 0 0.000 1.07
LHb intron excision ratio 0 0.000 1.16
LHb mRNA stability 0 0.000 1.00
Liver alternative polyA 0 0.000 0.97
Liver alternative TSS 0 0.000 1.05
Liver gene expression 0 0.000 1.04
Liver isoform ratio 0 0.000 1.03
Liver intron excision ratio 0 0.000 1.06
Liver mRNA stability 0 0.000 0.99
NAcc alternative polyA 0 0.000 1.07
NAcc alternative TSS 0 0.000 1.13
NAcc gene expression 1 0.016 1.10
NAcc isoform ratio 0 0.000 1.11
NAcc intron excision ratio 0 0.000 1.14
NAcc mRNA stability 0 0.000 1.15
OFC alternative polyA 0 0.000 1.06
OFC alternative TSS 0 0.000 1.17
OFC gene expression 0 0.000 1.10
OFC isoform ratio 0 0.000 1.12
OFC intron excision ratio 0 0.000 1.06
OFC mRNA stability 0 0.000 1.11
PL alternative polyA 0 0.000 1.03
PL alternative TSS 0 0.000 1.08
PL gene expression 0 0.000 1.08
PL isoform ratio 0 0.000 1.02
PL intron excision ratio 0 0.000 1.13
PL mRNA stability 0 0.000 1.06

avg chisq: Average Chi2 (squared Z-score) across all models in this panel for this trait.