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Delay disc. indifference point, 0s delay

Abnormal impulse behavior control/Impulsivity assay, delay discounting using an adjusting amount procedure: subject’s calculated indifference point for all exposures/repetitions of 0s delay sessions in 11-16 week old NIH heterogeneous stock rats for males and females (MEDPC V equipment, where immediate lever with 0s delay provides choice dependent adjusting amounts starting at 75 microliter of sucrose solution and delayed lever provides 150 microliter of sucrose solution) [microliter].

Tags: Behavior · Impulsivity · Delay discounting

Project: u01_suzanne_mitchell

1 significantly associated model · 1 unique gene

Significant Loci

# chr p0 p1 # assoc genes # joint models best TWAS P best SNP P cond SNP P % var exp joint genes
1 1 68581504 69974370 1 1 3.6e-08 0.22 6.4e-07 -1568 Syt5

p0: physical position of the start of the locus. p1: physical position of the end of the locus. # joint models: number of models selected by step-wise conditional analysis.

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Body weight 2.6 1 0 0 0 1 Syt5
Epididymis fat weight 2.2 1 0 0 0 1 Syt5
Glucose 12.1 1 0 0 0 1 Syt5
Right kidney weight 2.6 1 0 0 0 1 Syt5
Length with tail 1.3 1 0 0 0 1 Syt5
Length without tail 3.2 1 0 0 0 1 Syt5
Liver weight, left 10.2 1 0 0 0 1 Syt5
Liver weight, right 11.2 1 0 0 0 1 Syt5
Tibialis anterior weight 2.4 1 0 0 0 1 Syt5
Tibia length 7.5 1 0 0 0 1 Syt5
Std. dev. time between licks in bursts 22.7 1 1 100 0 1 Syt5
Water consumed over 24 hours 3.9 1 0 0 0 1 Syt5
Indifference point 0 sec 6.3 1 0 0 0 1 Syt5
Indifference point function ln k 8.8 1 0 0 0 1 Syt5
Indifference point function log k 8.8 1 0 0 0 1 Syt5
Delay discounting total patch changes 0 sec 5.8 1 0 0 0 1 Syt5
Delay discounting total patch changes 24 sec 10.3 1 0 0 0 1 Syt5
Delay discounting time to switch 0 sec 55.9 1 1 100 0 1 Syt5
Delay discounting water rate 0 sec 10.3 1 0 0 0 1 Syt5
Delay discounting water rate 12 sec 22.1 1 1 100 0 1 Syt5
Delay discounting water rate 18 sec 19.1 1 0 0 0 1 Syt5
Delay discounting water rate 24 sec 8.0 1 0 0 0 1 Syt5
Locomotor testing distance 2.7 1 0 0 0 1 Syt5
Light reinforcement 1 21.6 1 1 100 0 1 Syt5
Light reinforcement 2 21.6 1 1 100 0 1 Syt5
Reaction time num false alarms AUC 10.6 1 0 0 0 1 Syt5
Reaction time mean 5.1 1 0 0 0 1 Syt5
Reaction time mean AUC 6.2 1 0 0 0 1 Syt5
Median of all reaction times 7.0 1 0 0 0 1 Syt5
Reaction time omissions 5.3 1 0 0 0 1 Syt5
Reaction time false alarm rate 4.7 1 0 0 0 1 Syt5
Reaction time premature initiation rate 3.4 1 0 0 0 1 Syt5
Social response proportion 8.0 1 0 0 0 1 Syt5
Social responses 3.8 1 0 0 0 1 Syt5
Social time 18.1 1 0 0 0 1 Syt5
Conditioned locomotion 5.9 1 0 0 0 1 Syt5
Cocaine response after cond. corrected 18.2 1 0 0 0 1 Syt5
Cocaine response after cond. not corrected 16.4 1 0 0 0 1 Syt5
Saline control response 13.2 1 0 0 0 1 Syt5
Condit. Reinf. lever presses 9.9 1 0 0 0 1 Syt5
Condit. Reinf. lever reinforcers received 3.3 1 0 0 0 1 Syt5
Pavlov. Cond. change in total contacts 5.8 1 0 0 0 1 Syt5
Conditioned reinforcement - actives 22.3 1 0 0 0 1 Syt5
Conditioned locomotion 15.1 1 0 0 0 1 Syt5
Intermittent access intake day 1-15 change 7.2 1 0 0 0 1 Syt5
Intermittent access intake escalation 2 5.3 1 0 0 0 1 Syt5
Intermitt. access day 1 inactive lever presses 19.1 1 0 0 0 1 Syt5
Intermitt. access day 15 inactive lever presses 38.5 1 1 100 0 1 Syt5
Intermitt. access escalation Index 17.2 1 0 0 0 1 Syt5
Intermittent access day 1 total infusions 3.7 1 0 0 0 1 Syt5
Intermittent access day 15 total locomotion 4.7 1 0 0 0 1 Syt5
Intermittent access standard deviation 9.3 1 0 0 0 1 Syt5
Cocaine induced anxiety 4.3 1 0 0 0 1 Syt5
Post-drug Anxiety 10.2 1 0 0 0 1 Syt5
Baseline Anxiety 26.3 1 1 100 0 1 Syt5
Incentive Sensitization - Responses 6.8 1 0 0 0 1 Syt5
Incentive Sensitization - Breakpoint 8.6 1 0 0 0 1 Syt5
Progressive ratio test 1 active lever presses 3.8 1 0 0 0 1 Syt5
Short access day 1 total inactive lever presses 24.4 1 1 100 0 1 Syt5
Short access day 10 total inactive lever presses 4.8 1 0 0 0 1 Syt5
Short access day 10 total locomotion 11.2 1 0 0 0 1 Syt5
Short access total locomotion 13.1 1 0 0 0 1 Syt5
Compulsive drug intake 4.0 1 0 0 0 1 Syt5
One hour access (shock baseline) 24.4 1 1 100 0 1 Syt5
Number of responses in last shaping day 9.8 1 0 0 0 1 Syt5
Context. condit. distance diff. score 4.3 1 0 0 0 1 Syt5
Locomotion velocity, session 1 61.5 1 1 100 0 1 Syt5
Locomotion distance, session 1 22.4 1 1 100 0 1 Syt5
Locomotion velocity, session 2 20.6 1 0 0 0 1 Syt5
Locomotion distance, session 2 5.4 1 0 0 0 1 Syt5
Locomotion velocity, session 3 3.5 1 0 0 0 1 Syt5
Locomotion distance, session 3 8.7 1 0 0 0 1 Syt5
Locomotion velocity, session 7 6.0 1 0 0 0 1 Syt5
Locomotion distance, session 7 10.2 1 0 0 0 1 Syt5
Stereotopy head waving bouts, day 7 3.9 1 0 0 0 1 Syt5
Stereotopy head waving duration, day 7 3.5 1 0 0 0 1 Syt5
Locomotion velocity, session 8 15.7 1 0 0 0 1 Syt5
Locomotion distance, session 8 9.2 1 0 0 0 1 Syt5
Degree of sensitization stereotypy 3.7 1 0 0 0 1 Syt5
Time in familiar zone, hab. session 1 12.8 1 0 0 0 1 Syt5
Total zone transitions, hab. session 1 25.5 1 1 100 0 1 Syt5
Total locomotion distance, hab. session 1 19.3 1 1 100 0 1 Syt5
Locomotion velocity, hab. session 1 12.3 1 0 0 0 1 Syt5
Time in familiar zone, hab. session 2 14.1 1 0 0 0 1 Syt5
Total zone transitions, hab. session 2 7.9 1 0 0 0 1 Syt5
Total locomotion distance, hab. session 2 10.7 1 0 0 0 1 Syt5
Locomotion velocity, hab. session 2 13.6 1 0 0 0 1 Syt5
Total zone transitions, NPP test 4.1 1 0 0 0 1 Syt5
Pavlov. Cond. magazine entry latency 10.4 1 0 0 0 1 Syt5
Pavlov. Cond. lever contacts 4.8 1 0 0 0 1 Syt5
Pavlov. Cond. intertrial magazine entries 19.5 1 0 0 0 1 Syt5
Pavlov. Cond. response bias 13.4 1 0 0 0 1 Syt5
Bone: cortical porosity 7.7 1 0 0 0 1 Syt5
Bone: cortical thickness 3.2 1 0 0 0 1 Syt5
Bone: elastic displacement 7.7 1 0 0 0 1 Syt5
Bone: elastic work 5.8 1 0 0 0 1 Syt5
Bone: endosteal estimation 1.9 1 0 0 0 1 Syt5
Bone: post-yield work 11.6 1 0 0 0 1 Syt5
Bone: stiffness 4.5 1 0 0 0 1 Syt5
Bone: tissue strength 13.1 1 0 0 0 1 Syt5
Bone: trabecular tissue density 8.2 1 0 0 0 1 Syt5
Distance traveled before self-admin 57.6 1 1 100 0 1 Syt5
Distance traveled after self-admin 56.6 1 1 100 0 1 Syt5
Delta time in open arm before/after self-admin 18.0 1 0 0 0 1 Syt5
Diff in mean of infusions in LGA sessions 20.4 1 0 0 0 1 Syt5
Extinction: sum of active levers before priming 36.5 1 1 100 0 1 Syt5
Active lever presses in extinction session 6 17.9 1 0 0 0 1 Syt5
Time in closed arm before self-admin 4.1 1 0 0 0 1 Syt5
Time in closed arm after self-admin 22.3 1 0 0 0 1 Syt5
Time in open arm after self-admin 17.1 1 0 0 0 1 Syt5
Sum of active levers in priming session hrs 5-6 17.2 1 0 0 0 1 Syt5
Time to tail flick, vehicle, after self-admin 4.1 1 0 0 0 1 Syt5
Time to tail flick, test, before self-admin 57.2 1 1 100 0 1 Syt5
Time to tail flick, test, after self-admin 5.7 1 0 0 0 1 Syt5
Delta time to tail flick, vehicle, before/after SA 8.6 1 0 0 0 1 Syt5
Delta time to tail flick, test, before/after SA 42.4 1 1 100 0 1 Syt5
Ambulatory time before self-admin 36.6 1 1 100 0 1 Syt5
Ambulatory time after self-admin 61.3 1 1 100 0 1 Syt5
Total heroin consumption 5.8 1 0 0 0 1 Syt5
Delay disc. indifference point, 16s delay 24.1 1 0 0 0 1 Syt5
Delay disc. indifference point, 24s delay 9.6 1 0 0 0 1 Syt5
Change in fecal boli incidents, locomotor task 6.2 1 0 0 0 1 Syt5
Bouts of movement, locomotor time 1 56.9 1 1 100 0 1 Syt5
Total resting periods, locomotor time 1 37.3 1 1 100 0 1 Syt5
Vertical activity count, locomotor time 1 24.2 1 0 0 0 1 Syt5
Rest time, locomotor task time 2 9.1 1 0 0 0 1 Syt5
Vertical activity count, locomotor time 2 5.6 1 0 0 0 1 Syt5
Weight adjusted by age 8.3 1 0 0 0 1 Syt5
Seeking ratio, delayed vs. immediate footshock 29.7 1 1 100 0 1 Syt5
Locomotion in novel chamber 12.7 1 0 0 0 1 Syt5
Progressive ratio 7.6 1 0 0 0 1 Syt5
Food seeking constrained by brief footshock 133.4 1 1 100 0 1 Syt5
Seeking ratio, punishment vs. effort 16.5 1 0 0 0 1 Syt5
Run reversals in cocaine runway, females 8.3 1 0 0 0 1 Syt5
Cd content in liver 7.7 1 0 0 0 1 Syt5
Co content in liver 19.4 1 0 0 0 1 Syt5
Fe content in liver 3.6 1 0 0 0 1 Syt5
Rb content in liver 6.5 1 0 0 0 1 Syt5
Sr content in liver 66.7 1 1 100 0 1 Syt5
Zn content in liver 12.4 1 0 0 0 1 Syt5

chisq ratio: Average Chi2 statistic for the selected genes in the secondary trait, divided by the average statistic for all genes in the secondary trait. # genes+: Shared significant genes at Bonferroni correction. # genes++: Shared significant genes at transcriptome-wide significance. % genes++: Number of [++] genes as a percentage of primary trait’s total joint genes. corr: Correlation of effect sizes across the [+] genes.

Associations by panel

tissue modality # hits % hits/tests avg chisq
Adipose alternative polyA 0 0.000 1.05
Adipose alternative TSS 0 0.000 0.98
Adipose gene expression 0 0.000 1.08
Adipose isoform ratio 0 0.000 1.03
Adipose intron excision ratio 0 0.000 1.15
Adipose mRNA stability 0 0.000 1.05
BLA alternative polyA 0 0.000 1.00
BLA alternative TSS 0 0.000 1.16
BLA gene expression 0 0.000 1.14
BLA isoform ratio 0 0.000 1.10
BLA intron excision ratio 0 0.000 1.11
BLA mRNA stability 1 0.049 1.09
Brain alternative polyA 0 0.000 1.02
Brain alternative TSS 0 0.000 1.14
Brain gene expression 0 0.000 1.11
Brain isoform ratio 0 0.000 1.06
Brain intron excision ratio 0 0.000 1.11
Brain mRNA stability 0 0.000 1.09
Eye alternative polyA 0 0.000 1.14
Eye alternative TSS 0 0.000 1.23
Eye gene expression 0 0.000 1.08
Eye isoform ratio 0 0.000 1.45
Eye intron excision ratio 0 0.000 1.07
Eye mRNA stability 0 0.000 1.20
IL alternative polyA 0 0.000 0.85
IL alternative TSS 0 0.000 1.17
IL gene expression 0 0.000 1.11
IL isoform ratio 0 0.000 1.00
IL intron excision ratio 0 0.000 1.05
IL mRNA stability 0 0.000 1.07
LHb alternative polyA 0 0.000 0.87
LHb alternative TSS 0 0.000 1.08
LHb gene expression 0 0.000 1.09
LHb isoform ratio 0 0.000 1.02
LHb intron excision ratio 0 0.000 1.04
LHb mRNA stability 0 0.000 1.00
Liver alternative polyA 0 0.000 1.07
Liver alternative TSS 0 0.000 1.06
Liver gene expression 0 0.000 1.11
Liver isoform ratio 0 0.000 1.06
Liver intron excision ratio 0 0.000 1.18
Liver mRNA stability 0 0.000 1.07
NAcc alternative polyA 0 0.000 0.98
NAcc alternative TSS 0 0.000 1.24
NAcc gene expression 0 0.000 1.13
NAcc isoform ratio 0 0.000 1.03
NAcc intron excision ratio 0 0.000 1.03
NAcc mRNA stability 0 0.000 1.08
OFC alternative polyA 0 0.000 0.85
OFC alternative TSS 0 0.000 1.44
OFC gene expression 0 0.000 1.12
OFC isoform ratio 0 0.000 1.01
OFC intron excision ratio 0 0.000 1.10
OFC mRNA stability 0 0.000 1.00
PL alternative polyA 0 0.000 1.04
PL alternative TSS 0 0.000 1.18
PL gene expression 0 0.000 1.11
PL isoform ratio 0 0.000 1.05
PL intron excision ratio 0 0.000 1.09
PL mRNA stability 0 0.000 1.06

avg chisq: Average Chi2 (squared Z-score) across all models in this panel for this trait.