Hub : Traits

Delay disc. indifference point, 0s delay

Abnormal impulse behavior control/Impulsivity assay, delay discounting using an adjusting amount procedure: subject's calculated indifference point for all exposures/repetitions of 0s delay sessions in 11-16 week old NIH heterogeneous stock rats for males and females (MEDPC V equipment, where immediate lever with 0s delay provides choice dependent adjusting amounts starting at 75 microliter of sucrose solution and delayed lever provides 150 microliter of sucrose solution) [microliter].

Tags: Behavior · Impulsivity · Delay discounting

Project: u01_suzanne_mitchell

1 loci · 1 genes with independent associations · 1 total associated genes

Significant Loci

#	Chr	Start pos	End pos	# assoc genes	# joint models	Best TWAS P	Best GWAS P	Cond GWAS P	Joint genes
1	1	68581504	69974370	1	1	3.6e-08	2.23e-01	6.4e-07	Syt5

Pleiotropic Associations

Trait	Chi2 ratio	# genes+	# genes++	% genes++	Corr	Corr P	Genes
Body weight	2.58	1	0	0	0	1e+00	Syt5
Epididymis fat weight	2.21	1	0	0	0	1e+00	Syt5
Glucose	12.08	1	0	0	0	1e+00	Syt5
Right kidney weight	2.57	1	0	0	0	1e+00	Syt5
Length with tail	1.32	1	0	0	0	1e+00	Syt5
Length without tail	3.25	1	0	0	0	1e+00	Syt5
Liver weight, left	10.21	1	0	0	0	1e+00	Syt5
Liver weight, right	11.2	1	0	0	0	1e+00	Syt5
Tibialis anterior weight	2.35	1	0	0	0	1e+00	Syt5
Tibia length	7.53	1	0	0	0	1e+00	Syt5
Std. dev. time between licks in bursts	22.72	1	1	100	0	1e+00	Syt5
Water consumed over 24 hours	3.9	1	0	0	0	1e+00	Syt5
Indifference point 0 sec	6.32	1	0	0	0	1e+00	Syt5
Indifference point function ln k	8.79	1	0	0	0	1e+00	Syt5
Indifference point function log k	8.79	1	0	0	0	1e+00	Syt5
Delay discounting total patch changes 0 sec	5.75	1	0	0	0	1e+00	Syt5
Delay discounting total patch changes 24 sec	10.35	1	0	0	0	1e+00	Syt5
Delay discounting time to switch 0 sec	55.89	1	1	100	0	1e+00	Syt5
Delay discounting water rate 0 sec	10.34	1	0	0	0	1e+00	Syt5
Delay discounting water rate 12 sec	22.12	1	1	100	0	1e+00	Syt5
Delay discounting water rate 18 sec	19.1	1	0	0	0	1e+00	Syt5
Delay discounting water rate 24 sec	7.99	1	0	0	0	1e+00	Syt5
Locomotor testing distance	2.71	1	0	0	0	1e+00	Syt5
Light reinforcement 1	21.59	1	1	100	0	1e+00	Syt5
Light reinforcement 2	21.57	1	1	100	0	1e+00	Syt5
Reaction time num false alarms AUC	10.57	1	0	0	0	1e+00	Syt5
Reaction time mean	5.11	1	0	0	0	1e+00	Syt5
Reaction time mean AUC	6.17	1	0	0	0	1e+00	Syt5
Median of all reaction times	6.98	1	0	0	0	1e+00	Syt5
Reaction time omissions	5.26	1	0	0	0	1e+00	Syt5
Reaction time false alarm rate	4.67	1	0	0	0	1e+00	Syt5
Reaction time premature initiation rate	3.42	1	0	0	0	1e+00	Syt5
Social response proportion	7.98	1	0	0	0	1e+00	Syt5
Social responses	3.82	1	0	0	0	1e+00	Syt5
Social time	18.13	1	0	0	0	1e+00	Syt5
Conditioned locomotion	5.89	1	0	0	0	1e+00	Syt5
Cocaine response after cond. corrected	18.2	1	0	0	0	1e+00	Syt5
Cocaine response after cond. not corrected	16.42	1	0	0	0	1e+00	Syt5
Saline control response	13.17	1	0	0	0	1e+00	Syt5
Condit. Reinf. lever presses	9.91	1	0	0	0	1e+00	Syt5
Condit. Reinf. lever reinforcers received	3.29	1	0	0	0	1e+00	Syt5
Pavlov. Cond. change in total contacts	5.83	1	0	0	0	1e+00	Syt5
Conditioned reinforcement - actives	22.28	1	0	0	0	1e+00	Syt5
Conditioned locomotion	15.14	1	0	0	0	1e+00	Syt5
Intermittent access intake day 1-15 change	7.2	1	0	0	0	1e+00	Syt5
Intermittent access intake escalation 2	5.26	1	0	0	0	1e+00	Syt5
Intermitt. access day 1 inactive lever presses	19.07	1	0	0	0	1e+00	Syt5
Intermitt. access day 15 inactive lever presses	38.52	1	1	100	0	1e+00	Syt5
Intermitt. access escalation Index	17.22	1	0	0	0	1e+00	Syt5
Intermittent access day 1 total infusions	3.72	1	0	0	0	1e+00	Syt5
Intermittent access day 15 total locomotion	4.69	1	0	0	0	1e+00	Syt5
Intermittent access standard deviation	9.35	1	0	0	0	1e+00	Syt5
Cocaine induced anxiety	4.32	1	0	0	0	1e+00	Syt5
Post-drug Anxiety	10.17	1	0	0	0	1e+00	Syt5
Baseline Anxiety	26.3	1	1	100	0	1e+00	Syt5
Incentive Sensitization - Responses	6.78	1	0	0	0	1e+00	Syt5
Incentive Sensitization - Breakpoint	8.61	1	0	0	0	1e+00	Syt5
Progressive ratio test 1 active lever presses	3.75	1	0	0	0	1e+00	Syt5
Short access day 1 total inactive lever presses	24.45	1	1	100	0	1e+00	Syt5
Short access day 10 total inactive lever presses	4.84	1	0	0	0	1e+00	Syt5
Short access day 10 total locomotion	11.18	1	0	0	0	1e+00	Syt5
Short access total locomotion	13.05	1	0	0	0	1e+00	Syt5
Compulsive drug intake	4.02	1	0	0	0	1e+00	Syt5
One hour access (shock baseline)	24.39	1	1	100	0	1e+00	Syt5
Number of responses in last shaping day	9.84	1	0	0	0	1e+00	Syt5
Context. condit. distance diff. score	4.29	1	0	0	0	1e+00	Syt5
Locomotion velocity, session 1	61.51	1	1	100	0	1e+00	Syt5
Locomotion distance, session 1	22.42	1	1	100	0	1e+00	Syt5
Locomotion velocity, session 2	20.55	1	0	0	0	1e+00	Syt5
Locomotion distance, session 2	5.4	1	0	0	0	1e+00	Syt5
Locomotion velocity, session 3	3.52	1	0	0	0	1e+00	Syt5
Locomotion distance, session 3	8.71	1	0	0	0	1e+00	Syt5
Locomotion velocity, session 7	5.99	1	0	0	0	1e+00	Syt5
Locomotion distance, session 7	10.24	1	0	0	0	1e+00	Syt5
Stereotopy head waving bouts, day 7	3.93	1	0	0	0	1e+00	Syt5
Stereotopy head waving duration, day 7	3.51	1	0	0	0	1e+00	Syt5
Locomotion velocity, session 8	15.73	1	0	0	0	1e+00	Syt5
Locomotion distance, session 8	9.21	1	0	0	0	1e+00	Syt5
Degree of sensitization stereotypy	3.7	1	0	0	0	1e+00	Syt5
Time in familiar zone, hab. session 1	12.82	1	0	0	0	1e+00	Syt5
Total zone transitions, hab. session 1	25.53	1	1	100	0	1e+00	Syt5
Total locomotion distance, hab. session 1	19.26	1	1	100	0	1e+00	Syt5
Locomotion velocity, hab. session 1	12.27	1	0	0	0	1e+00	Syt5
Time in familiar zone, hab. session 2	14.1	1	0	0	0	1e+00	Syt5
Total zone transitions, hab. session 2	7.86	1	0	0	0	1e+00	Syt5
Total locomotion distance, hab. session 2	10.72	1	0	0	0	1e+00	Syt5
Locomotion velocity, hab. session 2	13.63	1	0	0	0	1e+00	Syt5
Total zone transitions, NPP test	4.12	1	0	0	0	1e+00	Syt5
Pavlov. Cond. magazine entry latency	10.45	1	0	0	0	1e+00	Syt5
Pavlov. Cond. lever contacts	4.84	1	0	0	0	1e+00	Syt5
Pavlov. Cond. intertrial magazine entries	19.53	1	0	0	0	1e+00	Syt5
Pavlov. Cond. response bias	13.37	1	0	0	0	1e+00	Syt5
Bone: cortical porosity	7.72	1	0	0	0	1e+00	Syt5
Bone: cortical thickness	3.19	1	0	0	0	1e+00	Syt5
Bone: elastic displacement	7.66	1	0	0	0	1e+00	Syt5
Bone: elastic work	5.83	1	0	0	0	1e+00	Syt5
Bone: endosteal estimation	1.95	1	0	0	0	1e+00	Syt5
Bone: post-yield work	11.59	1	0	0	0	1e+00	Syt5
Bone: stiffness	4.47	1	0	0	0	1e+00	Syt5
Bone: tissue strength	13.13	1	0	0	0	1e+00	Syt5
Bone: trabecular tissue density	8.22	1	0	0	0	1e+00	Syt5
Distance traveled before self-admin	57.56	1	1	100	0	1e+00	Syt5
Distance traveled after self-admin	56.65	1	1	100	0	1e+00	Syt5
Delta time in open arm before/after self-admin	18.04	1	0	0	0	1e+00	Syt5
Diff in mean of infusions in LGA sessions	20.43	1	0	0	0	1e+00	Syt5
Extinction: sum of active levers before priming	36.46	1	1	100	0	1e+00	Syt5
Active lever presses in extinction session 6	17.94	1	0	0	0	1e+00	Syt5
Time in closed arm before self-admin	4.09	1	0	0	0	1e+00	Syt5
Time in closed arm after self-admin	22.26	1	0	0	0	1e+00	Syt5
Time in open arm after self-admin	17.09	1	0	0	0	1e+00	Syt5
Sum of active levers in priming session hrs 5-6	17.22	1	0	0	0	1e+00	Syt5
Time to tail flick, vehicle, after self-admin	4.11	1	0	0	0	1e+00	Syt5
Time to tail flick, test, before self-admin	57.17	1	1	100	0	1e+00	Syt5
Time to tail flick, test, after self-admin	5.74	1	0	0	0	1e+00	Syt5
Delta time to tail flick, vehicle, before/after SA	8.61	1	0	0	0	1e+00	Syt5
Delta time to tail flick, test, before/after SA	42.42	1	1	100	0	1e+00	Syt5
Ambulatory time before self-admin	36.65	1	1	100	0	1e+00	Syt5
Ambulatory time after self-admin	61.31	1	1	100	0	1e+00	Syt5
Total heroin consumption	5.77	1	0	0	0	1e+00	Syt5
Delay disc. indifference point, 16s delay	24.13	1	0	0	0	1e+00	Syt5
Delay disc. indifference point, 24s delay	9.61	1	0	0	0	1e+00	Syt5
Change in fecal boli incidents, locomotor task	6.15	1	0	0	0	1e+00	Syt5
Bouts of movement, locomotor time 1	56.89	1	1	100	0	1e+00	Syt5
Total resting periods, locomotor time 1	37.3	1	1	100	0	1e+00	Syt5
Vertical activity count, locomotor time 1	24.22	1	0	0	0	1e+00	Syt5
Rest time, locomotor task time 2	9.12	1	0	0	0	1e+00	Syt5
Vertical activity count, locomotor time 2	5.62	1	0	0	0	1e+00	Syt5
Weight adjusted by age	8.26	1	0	0	0	1e+00	Syt5
Seeking ratio, delayed vs. immediate footshock	29.67	1	1	100	0	1e+00	Syt5
Locomotion in novel chamber	12.66	1	0	0	0	1e+00	Syt5
Progressive ratio	7.56	1	0	0	0	1e+00	Syt5
Food seeking constrained by brief footshock	133.39	1	1	100	0	1e+00	Syt5
Seeking ratio, punishment vs. effort	16.51	1	0	0	0	1e+00	Syt5
Run reversals in cocaine runway, females	8.33	1	0	0	0	1e+00	Syt5
Cd content in liver	7.7	1	0	0	0	1e+00	Syt5
Co content in liver	19.37	1	0	0	0	1e+00	Syt5
Fe content in liver	3.65	1	0	0	0	1e+00	Syt5
Rb content in liver	6.49	1	0	0	0	1e+00	Syt5
Sr content in liver	66.74	1	1	100	0	1e+00	Syt5
Zn content in liver	12.43	1	0	0	0	1e+00	Syt5

Associations by panel

Tissue	RNA modality	# hits	% hits/tests	Avg chisq
Adipose	alternative polyA	0	0	1.05
Adipose	alternative TSS	0	0	0.98
Adipose	gene expression	0	0	1.08
Adipose	isoform ratio	0	0	1.03
Adipose	intron excision ratio	0	0	1.15
Adipose	mRNA stability	0	0	1.05
BLA	alternative polyA	0	0	1
BLA	alternative TSS	0	0	1.16
BLA	gene expression	0	0	1.14
BLA	isoform ratio	0	0	1.1
BLA	intron excision ratio	0	0	1.11
BLA	mRNA stability	1	0	1.09
Brain	alternative polyA	0	0	1.02
Brain	alternative TSS	0	0	1.14
Brain	gene expression	0	0	1.11
Brain	isoform ratio	0	0	1.06
Brain	intron excision ratio	0	0	1.11
Brain	mRNA stability	0	0	1.09
Eye	alternative polyA	0	0	1.14
Eye	alternative TSS	0	0	1.23
Eye	gene expression	0	0	1.08
Eye	isoform ratio	0	0	1.45
Eye	intron excision ratio	0	0	1.07
Eye	mRNA stability	0	0	1.2
IL	alternative polyA	0	0	0.85
IL	alternative TSS	0	0	1.17
IL	gene expression	0	0	1.11
IL	isoform ratio	0	0	1
IL	intron excision ratio	0	0	1.05
IL	mRNA stability	0	0	1.07
LHb	alternative polyA	0	0	0.87
LHb	alternative TSS	0	0	1.08
LHb	gene expression	0	0	1.09
LHb	isoform ratio	0	0	1.02
LHb	intron excision ratio	0	0	1.04
LHb	mRNA stability	0	0	1
Liver	alternative polyA	0	0	1.07
Liver	alternative TSS	0	0	1.06
Liver	gene expression	0	0	1.11
Liver	isoform ratio	0	0	1.06
Liver	intron excision ratio	0	0	1.18
Liver	mRNA stability	0	0	1.07
NAcc	alternative polyA	0	0	0.98
NAcc	alternative TSS	0	0	1.24
NAcc	gene expression	0	0	1.13
NAcc	isoform ratio	0	0	1.03
NAcc	intron excision ratio	0	0	1.03
NAcc	mRNA stability	0	0	1.08
OFC	alternative polyA	0	0	0.85
OFC	alternative TSS	0	0	1.44
OFC	gene expression	0	0	1.12
OFC	isoform ratio	0	0	1.01
OFC	intron excision ratio	0	0	1.1
OFC	mRNA stability	0	0	1
PL	alternative polyA	0	0	1.04
PL	alternative TSS	0	0	1.18
PL	gene expression	0	0	1.11
PL	isoform ratio	0	0	1.05
PL	intron excision ratio	0	0	1.09
PL	mRNA stability	0	0	1.06