Chrna10

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	NAcc	gene expression	Chrna10	0.02	0.02	4.3e-03	0	0.01	0.01	0.01	1.6e-01	5.0e-03	9.0e-03	1.9e-02
2	NAcc	alternative TSS	XM_063272783.1	0.02	0.02	3.9e-03	0.01	0.01	0.01	0.01	2.6e-02	4.1e-03	1.4e-02	8.9e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2
Bone: apparent density	0.2	0.3	0.3	-0.6	0.5
Area under the delay curve	0.8	1.3	1.3	-1.1	1.1
BMI with tail	0.4	1.3	1.8	0.9	-1.3
BMI without tail	1.0	5.4	5.9	2.2	-2.4
Body weight	0.3	1.4	1.6	1.3	-1.1
Weight adjusted by age	0.3	1.0	1.2	1.1	-0.9
Bone surface	0.1	0.3	0.4	0.6	-0.4
Bone volume	0.0	0.0	0.1	0.2	-0.1
Breakpoint value in progressive ratio session	0.4	0.6	0.8	-0.9	0.7
Number of licking bursts	1.6	5.0	5.4	-2.3	2.1
Context. condit. distance diff. score	4.8	5.9	6.0	2.4	-2.4
Locomotion velocity, session 1	0.0	0.0	0.1	-0.2	-0.2
Locomotion distance, session 1	1.5	1.9	2.2	1.2	-1.5
Locomotion velocity, session 2	0.5	0.6	0.8	0.6	-0.9
Locomotion distance, session 2	1.0	1.4	1.8	1.0	-1.3
Locomotion velocity, session 3	0.6	0.7	0.7	0.9	-0.8
Locomotion distance, session 3	1.1	1.2	1.3	1.1	-1.1
Stereotopy head waving bouts, day 3	0.3	0.4	0.5	-0.5	0.7
Stereotopy head waving duration, day 3	0.4	0.5	0.5	0.7	-0.7
Locomotion velocity, session 7	0.1	0.1	0.2	0.1	-0.4
Locomotion distance, session 7	0.2	0.3	0.3	-0.6	0.5
Stereotopy head waving bouts, day 7	4.0	4.7	5.0	2.2	-2.1
Stereotopy head waving duration, day 7	4.2	5.1	5.4	2.3	-2.2
Locomotion velocity, session 8	1.6	2.0	2.1	1.4	-1.4
Locomotion distance, session 8	4.7	6.8	7.0	2.6	-2.6
Degree of sensitization distance	0.8	0.8	1.0	-0.8	1.0
Degree of sensitization stereotypy	7.3	8.1	8.6	2.9	-2.7
Conditioned locomotion	0.8	1.0	1.1	-0.9	1.0
Cocaine response after cond. corrected	1.1	1.7	1.8	-1.4	1.2
Cocaine response after cond. not corrected	0.2	0.3	0.4	-0.7	0.4
Cocaine response before conditioning	2.8	3.3	3.7	1.7	-1.9
Saline control response	0.8	1.1	1.6	1.3	-0.8
Bone: connectivity density	0.0	0.1	0.1	0.0	-0.4
Bone: cortical apparent density	1.7	2.6	2.7	-1.6	1.6
Bone: cortical area	0.0	0.0	0.1	0.2	-0.1
Bone: cortical porosity	0.1	0.1	0.1	-0.2	0.3
Bone: cortical porosity	0.0	0.0	0.0	0.0	0.1
Bone: cortical thickness	0.1	0.2	0.3	-0.5	0.2
Bone: cortical thickness	0.0	0.0	0.0	0.1	-0.1
Bone: cortical tissue density	1.7	2.6	2.7	-1.6	1.6
Condit. Reinf. active minus inactive responses	0.1	0.1	0.1	0.3	0.1
Condit. Reinf. active-inactive response ratio	0.1	0.1	0.1	0.3	0.2
Condit. Reinf. active responses	0.2	0.3	0.4	-0.3	0.7
Condit. Reinf. inactive responses	0.3	0.4	0.5	-0.7	0.6
Incentive salience index mean	0.0	0.1	0.1	0.0	0.3
Condit. Reinf. lever presses	0.0	0.0	0.0	0.0	-0.0
Condit. Reinf. active minus inactive responses	5.2	8.0	9.6	3.1	-2.6
Condit. Reinf. active-inactive response ratio	1.1	1.8	2.0	1.4	-1.3
Condit. Reinf. active responses	6.8	9.7	11.9	3.4	-2.8
Condit. Reinf. inactive responses	2.2	3.3	4.3	2.1	-1.5
Condit. Reinf. lever presses	14.2	20.6	23.1	4.8	-4.3
Condit. Reinf. lever reinforcers received	7.7	10.8	13.1	3.6	-2.9
Conditioned reinforcement - actives	0.0	0.1	0.1	0.3	-0.4
Conditioned reinforcement - inactives	0.7	2.0	2.2	-1.4	1.5
Conditioned locomotion	1.0	1.5	1.8	1.1	-1.3
Patch foraging indifference point 0 sec	1.5	4.2	4.5	2.1	-2.0
Patch foraging indifference point AUC	0.1	0.2	0.3	0.5	-0.4
Delay disc. indifference point, 0s delay	0.7	0.8	0.9	1.0	-0.8
Delay disc. indifference point, 16s delay	1.4	1.9	2.2	-1.3	1.5
Delay disc. indifference point, 2s delay	0.0	0.0	0.1	0.2	-0.0
Delay disc. indifference point, 24s delay	2.2	3.6	3.7	-1.9	1.9
Delay disc. indifference point, 4s delay	0.2	0.2	0.3	0.6	-0.3
Delay disc. indifference point, 8s delay	0.5	0.8	0.9	-0.9	0.9
Indifference point function ln k	0.1	0.3	0.3	0.5	-0.6
Indifference point function log k	0.1	0.3	0.3	0.5	-0.6
Patch foraging total patch changes 0 sec	1.4	4.0	4.2	2.1	-1.9
Patch foraging total patch changes 12 sec	0.6	0.8	1.0	1.0	-0.8
Patch foraging total patch changes 18 sec	0.6	1.5	1.7	1.3	-1.1
Patch foraging total patch changes 24 sec	0.3	1.1	1.4	1.2	-0.9
Patch foraging total patch changes 6 sec	1.1	1.9	2.1	1.5	-1.3
Patch foraging time to switch 0 sec	1.7	6.3	6.9	-2.6	2.4
Patch foraging water rate 0 sec	1.3	4.7	5.3	2.3	-2.0
Patch foraging water rate 12 sec	1.5	6.1	6.7	2.3	-2.6
Patch foraging water rate 18 sec	2.6	5.7	5.8	2.4	-2.4
Patch foraging water rate 24 sec	0.9	1.3	1.5	1.0	-1.2
Patch foraging water rate 6 sec	1.5	2.2	2.5	1.4	-1.6
Seeking ratio, delayed vs. immediate footshock	1.1	1.6	2.0	-1.4	1.1
Distance traveled before self-admin	0.0	0.0	0.0	-0.2	-0.1
Distance traveled after self-admin	0.2	0.4	0.6	0.4	-0.8
Extensor digitorum longus weight	0.1	0.2	0.3	-0.5	0.4
Bone: elastic displacement	0.6	0.7	1.0	-1.0	0.6
Bone: elastic work	0.6	0.8	1.3	-1.1	0.5
Bone: endosteal estimation	0.2	0.5	0.8	0.9	-0.5
Bone: endosteal perimeter	0.6	1.5	2.1	1.4	-1.0
Epididymis fat weight	0.1	0.5	0.7	-0.8	0.6
Delta time in closed arm before/after self-admin	1.8	1.7	1.7	-1.3	1.3
Delta time in open arm before/after self-admin	1.6	1.9	2.5	1.6	-1.2
Diff in mean of infusions in LGA sessions	3.6	6.5	7.1	-2.4	2.7
Delay discount exponential model param	0.9	1.2	1.2	1.1	-1.1
Extinction: sum of active levers before priming	0.0	0.0	0.0	-0.0	0.1
Active lever presses in extinction session 6	2.0	2.0	2.2	1.3	-1.5
Bone: final force	1.2	2.0	2.2	-1.3	1.5
Bone: final moment	0.8	1.2	1.4	-1.0	1.2
Food consumed during 24 hour testing period	2.2	4.4	4.5	2.1	-2.1
Glucose	0.1	0.2	0.3	0.3	-0.5
Heart weight	0.7	1.2	1.5	1.2	-0.9
Delay discount hyperbolic model param	0.8	1.0	1.0	1.0	-1.0
Intermittent access intake day 1-15 change	0.4	2.4	2.8	1.4	-1.7
Intermittent access intake escalation	0.5	2.9	3.4	1.6	-1.8
Intermittent access intake escalation 2	0.3	0.6	0.7	0.7	-0.8
Intermitt. access day 1 inactive lever presses	0.3	4.4	4.5	-2.1	2.1
Intermitt. access day 15 inactive lever presses	0.1	0.3	0.3	-0.5	0.6
Intermitt. access escalation Index	0.0	0.0	0.0	-0.1	0.1
Intermittent access day 1 total infusions	0.2	0.5	0.6	0.8	-0.6
Intermittent access day 15 total infusions	0.5	1.3	1.3	1.1	-1.1
Intermittent access terminal intake (last 3 days)	0.6	1.1	1.2	1.1	-1.0
Intermittent access total infusions	0.9	1.0	1.1	1.0	-1.0
Intermittent access day 1 locomotion	0.0	0.1	0.1	-0.2	0.4
Intermittent access day 15 total locomotion	0.1	0.4	0.5	0.5	-0.7
Intermittent access total locomotion	0.3	0.4	0.4	0.7	-0.6
Intermittent access standard deviation	0.1	0.3	0.4	0.5	-0.6
Left kidney weight	0.1	1.1	1.2	1.1	-1.0
Right kidney weight	0.1	1.0	1.3	1.1	-0.8
Cocaine induced anxiety	2.0	5.6	5.7	-2.4	2.4
Post-drug Anxiety	3.3	3.8	4.3	-1.8	2.1
Baseline Anxiety	0.7	1.2	1.6	1.3	-0.9
Tail length	0.3	1.9	3.0	1.7	-0.9
Length with tail	0.3	1.2	2.0	1.4	-0.6
Length without tail	0.0	0.0	0.1	-0.0	0.2
Times rat made contact with spout	0.4	0.5	0.5	-0.7	0.7
Lifetime Intake	1.4	1.7	1.8	1.3	-1.3
Liver weight, left	0.6	1.1	1.2	-1.0	1.1
Liver weight, right	0.7	1.2	1.5	-1.0	1.2
Locomotor activity	0.9	1.4	1.4	1.2	-1.2
Locomotor testing distance	1.2	3.0	3.3	1.8	-1.7
Locomotor testing rearing	0.2	0.7	0.9	0.9	-0.7
Locomotion in novel chamber	0.1	0.1	0.1	-0.4	0.1
Locomotion in novel chamber post-restriction	0.4	1.2	1.3	1.1	-1.1
Fecal boli incidents, locomotor time 1	1.0	2.7	2.9	-1.7	1.6
Change in fecal boli incidents, locomotor task	0.3	0.3	0.3	0.5	-0.5
Time >=10cm from walls, locomotor time 1	0.3	0.4	0.5	0.7	-0.5
Bouts of movement, locomotor time 1	0.1	0.1	0.2	-0.2	0.5
Total resting periods, locomotor time 1	0.2	0.2	0.3	-0.4	0.6
Rest time, locomotor task time 1	0.1	0.1	0.2	-0.3	0.4
Distance moved, locomotor task time 1	0.0	0.0	0.0	0.1	-0.2
Vertical activity count, locomotor time 1	0.0	0.1	0.1	-0.2	0.2
Time >=10cm from walls, locomotor time 2	0.4	1.1	1.6	1.3	-0.8
Bouts of movement, locomotor time 2	0.2	0.7	1.1	-0.6	1.0
Total resting periods, locomotor time 2	0.3	1.3	1.7	-1.0	1.3
Rest time, locomotor task time 2	1.4	2.4	2.8	-1.7	1.4
Distance moved, locomotor task time 2	1.9	2.5	2.8	1.7	-1.5
Vertical activity count, locomotor time 2	0.0	0.0	0.0	0.1	0.2
Light reinforcement 1	0.3	1.2	1.7	-1.3	0.8
Light reinforcement 2	0.5	1.1	1.7	0.7	-1.3
Bone: marrow area	0.1	0.3	0.5	0.7	-0.3
Bone: maximum diameter	0.9	1.9	2.3	1.5	-1.2
Bone: maximum force	0.4	0.8	0.9	-0.9	0.9
Bone: maximum moment	0.2	0.3	0.3	-0.5	0.6
Mean time between licks in bursts	0.4	2.1	3.2	1.8	-1.0
Mean num. licks in bursts	1.4	3.8	4.3	2.1	-1.8
Cd content in liver	0.6	0.6	0.7	-0.7	0.9
Co content in liver	0.3	0.4	0.6	0.8	-0.3
Cu content in liver	0.0	0.1	0.1	0.3	0.1
Fe content in liver	0.1	0.1	0.1	-0.3	0.3
K content in liver	0.5	0.5	0.5	-0.7	0.7
Mg content in liver	0.2	0.2	0.2	0.4	-0.5
Mn content in liver	0.5	0.6	0.9	-1.0	0.5
Na content in liver	1.1	1.3	1.3	1.1	-1.2
Rb content in liver	0.0	0.0	0.1	-0.1	0.3
Se content in liver	5.1	6.0	6.9	-2.6	2.3
Sr content in liver	2.0	1.7	2.1	1.2	-1.4
Zn content in liver	2.7	3.2	3.4	1.9	-1.7
Bone: minimum diameter	0.0	0.1	0.1	0.4	0.0
Time in familiar zone, hab. session 1	0.2	0.2	0.2	0.5	-0.5
Time in novel zone, hab. session 1	0.6	0.6	0.7	-0.7	0.9
Total zone transitions, hab. session 1	0.4	0.5	0.6	0.6	-0.8
Total locomotion distance, hab. session 1	0.3	0.5	0.6	-0.5	0.8
Locomotion velocity, hab. session 1	0.3	0.4	0.5	-0.5	0.7
Time in familiar zone, hab. session 2	1.4	1.6	2.1	1.5	-1.1
Time in novel zone, hab. session 2	0.2	0.2	0.4	-0.6	0.2
Total zone transitions, hab. session 2	3.8	4.9	4.9	2.2	-2.2
Total locomotion distance, hab. session 2	0.2	0.2	0.4	0.6	-0.3
Locomotion velocity, hab. session 2	0.1	0.1	0.2	0.5	-0.1
Novel to familiar place preference ratio	0.4	0.5	0.8	-0.4	0.9
Novelty place preference	0.3	0.4	0.6	-0.3	0.8
Time in novel zone, NPP test	0.2	0.2	0.4	-0.2	0.7
Total zone transitions, NPP test	0.7	1.0	1.3	0.8	-1.1
Total locomotion distance, NPP test	0.0	0.0	0.0	-0.2	0.0
Locomotion velocity, NPP test	0.1	0.1	0.2	-0.4	0.2
Intraocular pressure	0.0	0.1	0.1	0.2	-0.3
Delta distance traveled before/after self-admin	0.9	1.0	1.2	1.1	-0.9
Delta ambulatory time before/after self-admin	0.6	1.0	1.1	1.0	-0.9
Parametrial fat weight	0.0	0.1	0.2	-0.2	-0.4
Pavlov. Cond. lever latency	0.2	0.2	0.3	-0.6	0.3
Pavlov. Cond. magazine entry latency	3.3	4.2	4.7	2.2	-1.9
Pavlov. Cond. change in total contacts	0.3	0.3	0.5	0.7	-0.3
Pavlov. Cond. index score	1.6	2.0	2.3	1.5	-1.3
Pavlov. Cond. latency score	1.1	1.5	1.8	1.3	-1.1
Pavlov. Cond. lever contacts	0.5	0.6	0.7	0.8	-0.7
Pavlov. Cond. magazine entry number	2.5	3.1	3.6	-1.9	1.6
Pavlov. Cond. intertrial magazine entries	1.1	1.3	1.4	-1.2	1.1
Pavlov. Cond. lever-magazine prob. diff.	1.3	1.6	1.9	1.4	-1.2
Pavlov. Cond. response bias	1.4	1.7	1.9	1.4	-1.2
Pavlov. Cond. lever latency	20.3	28.5	30.7	-5.5	5.1
Pavlov. Cond. magazine entry latency	7.4	10.4	11.1	3.1	-3.3
Pavlov. Cond. change in total contacts	10.6	25.7	27.6	5.2	-4.9
Pavlov. Cond. index score	14.4	22.6	23.7	4.9	-4.6
Pavlov. Cond. latency score	12.9	20.8	21.4	4.6	-4.5
Pavlov. Cond. lever contacts	17.2	25.4	27.7	5.3	-4.8
Pavlov. Cond. magazine entry number	11.7	15.2	15.4	-3.9	3.9
Pavlov. Cond. intertrial magazine entries	0.1	0.3	0.5	-0.3	0.7
Pavlov. Cond. lever-magazine prob. diff.	14.0	21.6	22.7	4.8	-4.5
Pavlov. Cond. response bias	21.1	29.2	31.0	5.6	-5.2
Time in closed arm before self-admin	2.4	4.2	4.3	2.1	-2.0
Time in closed arm after self-admin	0.5	0.6	0.6	-0.8	0.8
Time in open arm before self-admin	4.1	4.9	5.9	-2.4	2.0
Time in open arm after self-admin	0.0	0.0	0.0	0.2	-0.0
Bone: periosteal estimation	0.1	0.3	0.5	0.7	-0.4
Bone: periosteal perimeter	0.6	1.1	1.4	1.2	-0.9
Bone: post-yield work	0.1	0.1	0.1	0.3	-0.3
Progressive ratio test 1 active lever presses	0.0	0.0	0.0	-0.0	0.0
Progressive ratio test 1 breakpoint	0.0	0.0	0.0	-0.1	0.1
Progressive ratio test 1 inactive lever presses	0.2	0.7	0.7	-0.8	0.8
Progressive ratio test 2 active lever presses	0.0	0.0	0.0	0.2	-0.1
Progressive ratio test 2 breakpoint	0.0	0.0	0.1	0.2	-0.2
Progressive ratio test 2 inactive lever presses	0.0	0.0	0.0	0.1	-0.2
Incentive Sensitization - Responses	0.0	0.1	0.1	0.3	-0.3
Incentive Sensitization - Breakpoint	0.1	0.1	0.2	0.4	-0.4
Sum of active levers in priming session hrs 5-6	0.3	0.3	0.4	0.5	-0.6
Progressive ratio	0.6	1.9	2.2	1.3	-1.5
Food seeking constrained by brief footshock	1.8	2.2	2.6	1.6	-1.3
Seeking ratio, punishment vs. effort	0.0	0.0	0.1	0.3	0.0
Retroperitoneal fat weight	0.7	3.1	3.5	-1.9	1.7
Reaction time number correct	0.0	0.1	0.1	0.2	-0.4
Reaction time mean minus median	0.0	0.2	0.3	0.5	-0.3
Reaction time mean minus median AUC	0.0	0.3	0.3	0.6	-0.4
Reaction time num false alarms	3.1	5.3	5.3	-2.3	2.3
Reaction time num false alarms AUC	2.0	4.5	4.6	-2.2	2.1
Reaction time trials correct on left	0.0	0.1	0.1	0.2	-0.4
Reaction time trials on left	0.0	0.1	0.1	0.2	-0.3
Reaction time mean	2.0	4.4	4.6	-2.0	2.2
Reaction time mean AUC	2.1	5.0	5.2	-2.2	2.3
Median of all reaction times	4.1	6.4	6.5	-2.5	2.5
Reaction time omissions	0.3	0.5	0.5	-0.7	0.6
Reaction time false alarm rate	3.1	4.3	4.3	-2.1	2.0
Reaction time premature initiation rate	0.8	1.3	1.7	1.3	-0.9
Reaction time premature initiations	0.4	1.2	1.4	1.2	-1.0
Std. dev. reaction times	0.2	0.8	1.1	-0.7	1.1
Reaction time trials completed	0.0	0.1	0.1	0.2	-0.3
Reaction time trials AUC	0.0	0.1	0.1	0.2	-0.3
Run reversals in cocaine runway, females	0.3	0.3	0.4	0.6	-0.5
Run reversals in cocaine runway, males	0.6	0.6	0.7	-0.8	0.8
Latency to leave start box in cocaine runway	2.1	2.8	3.0	-1.7	1.6
Latency to leave start box in cocaine runway, F	2.7	3.4	3.6	-1.8	1.9
Latency to leave start box in cocaine runway, M	0.2	0.1	0.3	-0.5	0.2
Std. dev. time between licks in bursts	0.1	0.1	0.2	0.5	0.0
Total sessions with >9 infusions	1.7	2.1	2.2	1.5	-1.4
Short access day 1 total inactive lever presses	0.3	0.6	0.7	-0.7	0.8
Short access day 10 total inactive lever presses	0.4	3.0	3.0	-1.7	1.7
Short access day 1 total infusions	0.9	1.8	2.1	1.5	-1.2
Short access day 10 total infusions	1.0	1.7	1.7	1.3	-1.3
Short access total infusions	1.6	2.2	2.4	1.6	-1.4
Short access day 1 locomotion	0.7	1.1	1.1	1.0	-1.1
Short access day 10 total locomotion	0.2	0.9	1.0	0.9	-1.0
Short access total locomotion	0.2	0.2	0.3	0.4	-0.6
One hour access (0.3 mA shock)	0.7	0.8	0.9	0.9	-1.0
Compulsive drug intake	0.2	0.3	0.4	-0.7	0.4
One hour access (shock baseline)	0.9	2.4	2.4	1.5	-1.6
Social response proportion	0.2	0.3	0.3	-0.5	0.6
Social responses	0.6	0.8	1.0	-0.8	1.0
Social time	1.5	2.4	2.9	-1.7	1.4
Soleus weight	0.4	1.2	1.4	-1.0	1.2
Bone: stiffness	1.9	3.4	3.9	-1.7	2.0
Tibialis anterior weight	0.0	0.0	0.1	-0.1	0.3
Time to tail flick, vehicle, before self-admin	1.4	1.7	1.7	1.3	-1.3
Time to tail flick, vehicle, after self-admin	0.1	0.3	0.4	0.6	-0.4
Time to tail flick, test, before self-admin	1.4	1.6	2.2	1.5	-1.0
Time to tail flick, test, after self-admin	0.1	0.1	0.2	0.5	0.0
Delta time to tail flick, vehicle, before/after SA	0.3	0.3	0.4	-0.5	0.6
Delta time to tail flick, test, before/after SA	0.6	0.8	0.9	-1.0	0.8
Tibia length	0.4	1.0	1.2	1.1	-0.9
Ambulatory time before self-admin	0.0	0.1	0.2	-0.4	0.2
Ambulatory time after self-admin	0.5	0.8	1.0	0.7	-1.0
Bone: tissue strength	0.1	0.1	0.1	-0.1	-0.4
Total heroin consumption	0.4	0.5	0.6	0.7	-0.8
Bone: trabecular number	0.4	0.8	1.1	-1.0	0.7
Bone: trabecular spacing	1.1	1.6	1.8	1.2	-1.4
Bone: trabecular thickness	0.9	1.3	1.6	-1.0	1.3
Bone: trabecular tissue density	3.4	6.0	7.0	-2.2	2.6
Water consumed over 24 hours	0.2	0.3	0.3	-0.6	0.5
Number of responses in last shaping day	2.1	2.7	3.1	-1.5	1.8